id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-343448-xhm97wy2	Rinaldi, Andrea	RNA to the rescue: RNA is one of the most promising targets for drug development given its wide variety of uses	2020-06-26		.txt	text/plain	2934	167	49	In brief, RNAi works through gene silencing, degrading the mRNA for a specific protein through the coordinated action of double-stranded RNA and a complex biochemical machinery it activates (Fig 1) . The spearhead is mRNA-1273, which encodes a prefusion-stabilized form of the spike (S) protein of SARS-CoV-2, developed at an unusually fast rate (first volunteer injected on Mach 16, only 65 days after the publication of the virus sequence) by Moderna, a biotech based in Cambridge, Massachusetts (https://www.modernatx.c om/). Multi-component proteins that would be impossible to target with other systems are accessible with RNA technology, as recently demonstrated by the generation of a multi-antigenic mRNA vaccine encoding human cytomegalovirus glycoproteins gB and pentameric complex (John et al, 2018) . CV9202, for example, is a mRNA encoding six antigens usually expressed in non-small-cell lung cancer (NSCLC), developed by CureVac, a biotech based in Tübingen, Germany (https://www.curevac.com/), in collaboration with Boehringer Ingelheim.	./cache/cord-343448-xhm97wy2.txt	./txt/cord-343448-xhm97wy2.txt