id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-339726-eg0hajzl	Jamrozik, Euzebiusz	Coronavirus Human Infection Challenge Studies: Assessing Potential Benefits and Risks	2020-08-25		.txt	text/plain	3643	154	40	Novel research designs, particularly where such studies might be controversial as in the case of SARS-CoV-2 HCS, require especially careful ethical evaluation including rigorous risk-benefit assessments as well as timely, thorough, public engagement ( WHO Working Group for Guidance on Human Challenge Studies in COVID-19 2020; Bambery et al. To be ethically acceptable, SARS-CoV-2 HCS would need to have multiple risk minimization strategies in place, including (i) selection of low risk participants (e.g., healthy young adults 1 ), (ii) careful strain selection and development, (iii) careful titration of viral dose, (iv) early diagnosis and availability of all necessary medical care, (v) long-term follow-up of participants, (vi) compensation for any lasting harms, and (vii) stringent infection control including measures to protect and screen research staff for infection (WHO Working Group for Guidance on Human Challenge Studies in COVID-19 2020). Tensions between public health and vaccine research priorities: A comparative modelling assessment of the risks and benefits of SARS-CoV-2 vaccine field trials versus human challenge studies	./cache/cord-339726-eg0hajzl.txt	./txt/cord-339726-eg0hajzl.txt