id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-324219-z1nigtb5	Bradbury, Jane	Custom-made vaccines at speed	2003-06-15		.txt	text/plain	977	54	54	A concept called reverse genetics has recently enabled researchers at the St Jude Children's Research Hospital (http://www.stjude.org) to construct an experimental vaccine against H5N1, a potential pandemic influenza strain, in less than a month. This flu vaccine will be the first produced by reverse genetics to go into clinical trial, and the speed with which it was produced, comments Rino Rappuoli, Vice President of Vaccine Research at Chiron Corporation (http://www.chiron.com) 'could be critical if H5N1 turns out to be the next, long-overdue pandemic strain to emerge from the Far East'. For example, says Kawaoka, 'many companies are planning to use reverse genetics to produce attenuated flu strains to be used as live vaccines that should give more protection than current inactivated vaccines'. Several laboratories are engineering coronavirus genomes as vectors for vaccine development and gene therapy, says Enjuanes, so it should be possible to make vaccines for SARS by adapting the available infectious cDNA clones.	./cache/cord-324219-z1nigtb5.txt	./txt/cord-324219-z1nigtb5.txt