id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-296831-wdpatr2z	Matoo, Javaid Jeelani	Resiquimod enhances mucosal and systemic immunity against avian infectious bronchitis virus vaccine in the chicken	2018-04-07		.txt	text/plain	5017	291	56	Earlier, we reported that a toll-like-receptor 7 (TLR7) agonist, resiquimod (R-848), stimulated the systemic immunity when adjuvanted with the inactivated Newcastle disease virus vaccine in the chicken. Here, we report the effect of R-848 when adjuvanted with live or inactivated avian infectious bronchitis virus (IBV) vaccines with special emphasis on mucosal immunity. R-848 enhanced the antigen specific humoral and cellular immune responses when co-administered with the vaccines as evidenced by an increase in the antibody titre in ELISA and stimulation index in lymphocyte transformation test (LTT) till 35 dpi and increased proportion of CD4(+) and CD8(+) T cells on 21 dpi in the flow cytometry. Co-administration of R-848 with live or inactivated IBV vaccine significantly increased the IgA response in the tear and intestinal secretion from 21 dpi, which was maintained till 35 dpi as compared to the vaccine alone group (P < 0.01).	./cache/cord-296831-wdpatr2z.txt	./txt/cord-296831-wdpatr2z.txt