id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-285883-rlliacex	Kremer, Eric J.	Pros and Cons of Adenovirus-Based SARS-CoV-2 Vaccines	2020-10-09		.txt	text/plain	1486	83	55	These advances include production and purification methods, genetic incorporation of epitopes into the capsid so that mononuclear phagocytes present these antigens via major histocompatibility complex (MHC) class I and II pathways, cloaking the capsid with polymers/shields to prevent neutralization by antibodies (NAbs), retargeting the vector to professional antigen-presenting cells, using helper-dependent vectors (so that the vector-infected cell only expresses the target epitopes and not Ad antigens), using Ad types with a lower level of seroprevalence in some populations, and single-cycle replication of vaccines to produce massive amounts of antigens. When injected with a bolus of Ad antigens (the vaccine), the response includes re-activation of anti-Ad effector memory T cells (T EM s), which return via homing receptors to the mucosal environments-where most Ad infections occur-and increased production of antibodies. Few can argue with the preclinical data that demonstrate that Ad-based vaccines generate rapid, antigen-targeted immune response in mice, rabbits, hamsters, and monkeys.	./cache/cord-285883-rlliacex.txt	./txt/cord-285883-rlliacex.txt