id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-282246-wyanwvxa	Sen, Adrish	Chapter 40 The Role of Innate Immunity in Regulating Rotavirus Replication, Pathogenesis, and Host Range Restriction and the Implications for Live Rotaviral Vaccine Development	2020-12-31		.txt	text/plain	7562	325	35	During RV infection in human enteroid cultures [19] and in different species of mammals [20À25], different types of IFNs are secreted, and as will be discuss below, antiviral actions of these IFNs are actively countered in a host-range-specific manner by pathogenic RVs. Of the IFNs, type I IFN is mostly expressed in the intestinal hematopoietic cell compartment rather than in the epithelium where RV primarily replicates [26] . In addition, IFN sensitivity of RVs encoding full-length "functional" NSP1 proteins also occurs in specific cell lines, possibly reflecting NSP1's inability to target host innate factors across different species [49] . Remarkably, in addition to these viral effects in infected cells, RV also potently inhibits STAT1 phosphorylation in uninfected bystander cells in response to different types of IFNs (5) . The active human IFN response to these heterologous RV vaccines suppresses their replication sufficiently to restrict pathogenicity and reactogenicity but not so much that the generation of effective RV immunity is suppressed.	./cache/cord-282246-wyanwvxa.txt	./txt/cord-282246-wyanwvxa.txt