id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-279260-tdvb0fhv	Lv, Huibin	COVID‐19 vaccines: knowing the unknown	2020-05-21		.txt	text/plain	1476	98	46	It is also important to note that T-cell immunity was found to be elicited by SARS-CoV or MERS-CoV DNA vaccines (both express trimeric spike protein) [7, 9] . Determining which adjuvants can enhance protective vaccine response to SARS-CoV-2 will be important. For example, the MF59-adjuvanted influenza vaccine, Fluad, is only licensed and approved for adults aged 65 years and older, to elicit a higher protective immune response in the elderly This article is protected by copyright. To accelerate vaccine development, animal infection models for SARS-CoV-2 are needed. Although macaques show COVID-19-like disease upon SARS-CoV-2 infection, the non-human primate model is usually not readily accessible to most laboratories [27] . Expressing hACE2 through adenoviral transduction may provide another possible approach to generate a mouse model for SARs-CoV-2 infection. For example, a conserved CD4 T-cell epitope can mediate cross-reactive protection between SARS-CoV and MERS-CoV [38] .	./cache/cord-279260-tdvb0fhv.txt	./txt/cord-279260-tdvb0fhv.txt