id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-267897-w4pbq2lb	Lindblad, E. B.	Chapter 18 Mineral Adjuvants ∗ ∗ The present chapter is an updated version of the chapter “Mineral Adjuvants,” published in Immunopotentiators in Modern Vaccines, p. 217–233. Ed. Virgil Schijns & Derek O'Hagan, Elsevier Science Publishers (2005).	2017-12-31		.txt	text/plain	9771	501	42	6 Vaccine preparations based on adsorption of the antigen onto a preformed aluminum hydroxide adjuvant are referred to as aluminum-adsorbed vaccines, in contrast to the alum-precipitated vaccines mentioned earlier. Here it was shown 42,43 that aluminum hydroxide had an inhibiting effect, whereas aluminum phosphate adjuvant augmented the immune response against the antigen encoded by the DNA nucleotide. In 2002, a group at University of Lausanne, headed by J€ urg Tschopp, defined the inflammasome as "a molecular platform triggering activation of inflammatory caspases and processing of pro-IL-b." 85 This initiated a new line of research leading to a possible explanation for the mechanisms of action of aluminum adjuvants in the early phases of the immune response with the stimulation and excretion of proinflammatory cytokines. Effect of the strength of adsorption of hepatitis B surface antigen to aluminum hydroxide adjuvant on the immune response	./cache/cord-267897-w4pbq2lb.txt	./txt/cord-267897-w4pbq2lb.txt