id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-266259-0f0guyea	Chandler, Rebecca E.	Optimizing safety surveillance for COVID-19 vaccines	2020-06-17		.txt	text/plain	1412	67	40	Infrastructure for safety surveillance Guidance for the clinical evaluation of vaccines is provided by large public health and regulatory authorities such as the WHO 6 . Routine surveillance for safety signals is based upon a statistical pair-wise analysis that detects disproportionality between the number of observed reports and the number of expected reports of a single adverse event for a single vaccine (such as febrile seizure for pneumococcal vaccine), followed by clinical validation and assessment of the case series for that vaccine and that AEFI. By contrast, within many low-income and middleincome countries, vaccines are largely administered by national immunization centres, which are also responsible for collecting data on AEFIs. Support to the national immunization programmes for safety surveillance has been provided by the Global Vaccine Safety Blueprint (GVSB) of the WHO 8 . Real-time global data exchange is essential as the pooling of reports of AEFIs into larger databases will allow for the earlier detection of safety signals.	./cache/cord-266259-0f0guyea.txt	./txt/cord-266259-0f0guyea.txt