id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-263277-m4too6ob	Guzmán, Carlos Alberto	Next Generation Influenza Vaccines: Looking into the Crystal Ball	2020-08-21		.txt	text/plain	1921	102	32	In their review article, the authors also presented a comprehensive summary of the current efforts to improve the influenza vaccines produced using standard existing technologies. In this particular context, animal studies support the potential of exploiting this strategy to generate universal or at least broader next generation vaccines providing heterosubtypic protection by stimulating long-lasting T cell resident memory cells. As described in the review, a universal vaccine based on peptides should mimic more closely the immune responses observed after natural infections by inducing both cross-reactive peripheral and tissue resident CD8 T cells in addition to cross-reactive antibodies and CD4 T follicular and helper cells. However, influenza vaccines based on both traditional and emerging technologies face the major constraint represented by the immune history of the individual vaccinees.	./cache/cord-263277-m4too6ob.txt	./txt/cord-263277-m4too6ob.txt