id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-261876-7rsc803x	Kaslow, David C.	Certainty of success: three critical parameters in coronavirus vaccine development	2020-05-25		.txt	text/plain	6462	305	36	In considering the "certainty of success" in development of human coronavirus vaccines, particularly SARS-CoV-2, a third, related critical parameter is proposed—infectious inoculum intensity, at an individual-level, and force of infection, at a population-level. Reducing the infectious inoculum intensity (and force of infection, at a population-level) is predicted to lengthen the incubation period, which in turn is predicted to reduce the severity of illness, and increase the opportunity for an anamnestic response upon exposure to the circulating virus. The one factor that emerges for consideration in SARS-CoV-2 vaccine development and implementation is reducing the infectious inoculum intensity (and force of infection, at a populationlevel) to lengthen the incubation period, reduce the severity of illness, and increase the opportunity for an anamnestic response upon exposure to the circulating virus.	./cache/cord-261876-7rsc803x.txt	./txt/cord-261876-7rsc803x.txt