id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-257899-l866puqk	Yun, Cheol-Heui	Nanoparticles to Improve the Efficacy of Vaccines	2020-05-02		.txt	text/plain	1843	82	34	The authors concentrated on the use of flagellin, a potent inducer of innate immunity via toll-like receptor 5, as an adjuvant to formulate human immunodeficiency virus (HIV)-based nanoparticle B cell-targeting vaccines that display either the HIV-1 envelope protein (Env) or a model antigen, hen egg lysozyme (HEL). [6] discussed biomimetic nanoparticles (NPs) to deliver vaccines for the treatment of diseases including HIV, malaria, some tumors and bacterial diseases due to their beneficial advantages such as improved antigen stability, targeted delivery, long-time controlled release and evasion of immune responses. The authors showed the induction of specific cytotoxic T cell responses to HLA-A2-restricted and hepatitis B virus epitopes due to the ability of the filamentous rod, internalized into APCs. It seems likely that the targeted delivery of these NPs in new-generation vaccines against tumors such as melanoma and mastocytoma might be realized, although clinical trials are necessary to establish their safety in humans.	./cache/cord-257899-l866puqk.txt	./txt/cord-257899-l866puqk.txt