id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-021937-p9vqpazu	Tsai, Theodore F.	Immunization in the Asia-Pacific Region	2017-07-17		.txt	text/plain	9479	392	35	However, an increasing global integration is taking place, as multinational companies acquire Asian manufacturers (e.g., Sanofi-Aventis, France, acquired Shantha Biotechnics, India); Asian companies acquire or obtain technologies and distribution rights from European countries (e.g., inactivated polio vaccine by Serum Institute of India Ltd. acquiring Bilthoven Biologicals, Netherlands; Astellas, Japan, acquiring recombinant influenza hemagglutinin from Protein Sciences, U.S.; Thai Government Pharmaceutical Organization acquiring chimeric JE vaccine from Sanofi-Pasteur, France; and Biological Evans, India, acquiring JE vaccine from Intercell AG, Austria); and vaccine codevelopment is agreed between entities in developed and Asian countries (e.g., genetically modified, inactivated HIV vaccine codeveloped by Sumagen, Korea, and the University of Western Ontario, Canada; mycobacterial proteinAg85A candidate tuberculosis vaccine codeveloped by Tianjin CanSino Biotechnology, China, and McMaster University, Canada; universal influenza vaccine codeveloped by Xiamen Wantai and Sanofi-Pasteur, France; and novel pneumococcal conjugate vaccine codeveloped by SK Chemicals, Korea and Sanofi-Pasteur, France). The widely used first-generation inactivated suckling mouse brain (SMB)-derived vaccine is being replaced rapidly in economically disadvantaged countries by the Chinese developed and manufactured live attenuated or inactivated vaccine (SA14-14-2 strain) grown in primary baby hamster kidney (PHK) cells and in higher-income countries with Vero cell-derived inactivated vaccines (licensed in the United States, Australia, Canada, and Europe, as well as several Asian countries) or a replicating chimeric yellow fever-JE virus recombinant vaccine (manufactured in Thailand).	./cache/cord-021937-p9vqpazu.txt	./txt/cord-021937-p9vqpazu.txt