id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-004078-d1pd09zj	Mettu, Ravinder	Synthetic carbohydrate-based vaccines: challenges and opportunities	2020-01-03		.txt	text/plain	11531	567	37	The majority of the licensed carbohydrate-based vaccines such as Streptococcus pneumonia, Neisseria meningitides, Haemophilus influenzae type b and Salmonella typhi Vi belongs to this category in which the carbohydrate antigens were isolated form microbial cultures and further conjugated to the carrier protein [32] . Many attempts to develop a monovalent MenB conjugate vaccine failed because the structural similarity between the capsular polysaccharides (comprised of α-2,8linked sialic acid) of MenB and components of the human neuraonal cells caused autoimmune issues in clinical tests. In short, the unimolecular pentavalent vaccines that combined several carbohydrate antigens and carrier protein conjugates could simulate immune response against the heterogeneous carbohydrate epitopes expressed on the surface of cancer cells. To overcome the shortage of MOE, many studies focus on modification of TACAs vaccines, which not only could generate stronger immunogenicity but also induce cross-reactive antibodies recognizing native carbohydrate antigens on the tumor cells.	./cache/cord-004078-d1pd09zj.txt	./txt/cord-004078-d1pd09zj.txt