id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-000194-cwzpb8fu	Haque, Azizul	Confronting Potential Influenza A (H5N1) Pandemic with Better Vaccines	2007-10-17		.txt	text/plain	5237	257	44	To test the hypothesis that whole-virion would be more immunogenic than conventional split-virion or subunit vaccines and may be adaptable to the antigen-sparing strategy, an inactivated, monovalent infl uenza A (H5N1), whole-virion vaccine was prepared from a highly virulent strain A/Vietnam/1194/2004 strain by removing the polybasic amino acids at the cleavage site, making the virus no longer pathogenic. Vaccination of mice with a live attenuated infl uenza vaccine or an alum-adjuvanted inactivated infl u-enza vaccine based on a related H5 HA from a nonpathogenic avian infl uenza virus, A/Duck/Pottsdam/1042-6/86 (H5N2), limited the disease severity and reduced deaths following challenge with a current highly pathogenic infl uenza (H5N1) (23) . Genes of highly conserved proteins such as the nucleoprotein or M2 proteins could be included in adenovirus vector-based vaccines because immune responses against these infl uenza viral antigens provide protection in animal models (24, 25) . Cross-protective immunity in mice induced by live-attenuated or inactivated vaccines against highly pathogenic infl uenza A (H5N1) viruses	./cache/cord-000194-cwzpb8fu.txt	./txt/cord-000194-cwzpb8fu.txt