id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-270556-lyrgwxit	Winnicka, Beata	CD13 is dispensable for normal hematopoiesis and myeloid cell functions in the mouse	2010-04-29		.txt	text/plain	8829	397	44	To address the function of myeloid CD13 directly, we created a CD13 null mouse and assessed the responses of purified primary macrophages or DCs from WT and CD13 null animals in cell assays and inflammatory disease models, where CD13 has been implicated previously. The latter study found enhanced phagocytosis of antibody-modified target cells and prolonged downstream signaling upon engagement of the Fc␥R in the presence of cross-linking mAb to CD13 in primary monocytes or myeloid cell lines, suggesting that CD13 may be a functional regulator of this receptor. Although overall adhesion of CD13 null cells was slightly lower than WT to untreated or control monolayers, treatment of the endothelial monolayer with cross-linking anti-mCD13 antibodies significantly increased the adhesion of WT but not CD13 null macrophages (Fig. 4D) , consistent with our results in human cells implicating CD13 as a myeloid adhesion molecule in a gain-of-function manner.	./cache/cord-270556-lyrgwxit.txt	./txt/cord-270556-lyrgwxit.txt