id sid tid token lemma pos cord-333405-ji58jbct 1 1 key key JJ cord-333405-ji58jbct 1 2 : : : cord-333405-ji58jbct 1 3 cord-333405-ji58jbct cord-333405-ji58jbct NN cord-333405-ji58jbct 1 4 authors author NNS cord-333405-ji58jbct 1 5 : : : cord-333405-ji58jbct 1 6 Morens Morens NNP cord-333405-ji58jbct 1 7 , , , cord-333405-ji58jbct 1 8 David David NNP cord-333405-ji58jbct 1 9 M. M. NNP cord-333405-ji58jbct 1 10 ; ; : cord-333405-ji58jbct 1 11 Folkers Folkers NNP cord-333405-ji58jbct 1 12 , , , cord-333405-ji58jbct 1 13 Gregory Gregory NNP cord-333405-ji58jbct 1 14 K. K. NNP cord-333405-ji58jbct 1 15 ; ; : cord-333405-ji58jbct 1 16 Fauci Fauci NNP cord-333405-ji58jbct 1 17 , , , cord-333405-ji58jbct 1 18 Anthony Anthony NNP cord-333405-ji58jbct 1 19 S. S. NNP cord-333405-ji58jbct 1 20 title title NN cord-333405-ji58jbct 1 21 : : : cord-333405-ji58jbct 2 1 The the DT cord-333405-ji58jbct 2 2 challenge challenge NN cord-333405-ji58jbct 2 3 of of IN cord-333405-ji58jbct 2 4 emerging emerge VBG cord-333405-ji58jbct 2 5 and and CC cord-333405-ji58jbct 2 6 re re VB cord-333405-ji58jbct 2 7 - - JJ cord-333405-ji58jbct 2 8 emerging emerge VBG cord-333405-ji58jbct 2 9 infectious infectious JJ cord-333405-ji58jbct 2 10 diseases disease NNS cord-333405-ji58jbct 2 11 date date NN cord-333405-ji58jbct 2 12 : : : cord-333405-ji58jbct 2 13 2004 2004 CD cord-333405-ji58jbct 2 14 - - HYPH cord-333405-ji58jbct 2 15 07 07 CD cord-333405-ji58jbct 2 16 - - HYPH cord-333405-ji58jbct 2 17 08 08 CD cord-333405-ji58jbct 2 18 journal journal NN cord-333405-ji58jbct 2 19 : : : cord-333405-ji58jbct 3 1 Nature nature NN cord-333405-ji58jbct 3 2 DOI doi NN cord-333405-ji58jbct 3 3 : : : cord-333405-ji58jbct 4 1 10.1038 10.1038 CD cord-333405-ji58jbct 4 2 / / SYM cord-333405-ji58jbct 4 3 nature02759 nature02759 NNP cord-333405-ji58jbct 4 4 sha sha NNP cord-333405-ji58jbct 4 5 : : : cord-333405-ji58jbct 5 1 e747780d29526e76fb97dc9ee3d46a7ac16a0011 e747780d29526e76fb97dc9ee3d46a7ac16a0011 NNP cord-333405-ji58jbct 6 1 doc_id doc_id CD cord-333405-ji58jbct 7 1 : : : cord-333405-ji58jbct 7 2 333405 333405 CD cord-333405-ji58jbct 7 3 cord_uid cord_uid NNS cord-333405-ji58jbct 7 4 : : : cord-333405-ji58jbct 8 1 ji58jbct ji58jbct NNP cord-333405-ji58jbct 8 2 Infectious infectious JJ cord-333405-ji58jbct 8 3 diseases disease NNS cord-333405-ji58jbct 8 4 have have VBP cord-333405-ji58jbct 8 5 for for IN cord-333405-ji58jbct 8 6 centuries century NNS cord-333405-ji58jbct 8 7 ranked rank VBN cord-333405-ji58jbct 8 8 with with IN cord-333405-ji58jbct 8 9 wars war NNS cord-333405-ji58jbct 8 10 and and CC cord-333405-ji58jbct 8 11 famine famine NN cord-333405-ji58jbct 8 12 as as IN cord-333405-ji58jbct 8 13 major major JJ cord-333405-ji58jbct 8 14 challenges challenge NNS cord-333405-ji58jbct 8 15 to to IN cord-333405-ji58jbct 8 16 human human JJ cord-333405-ji58jbct 8 17 progress progress NN cord-333405-ji58jbct 8 18 and and CC cord-333405-ji58jbct 8 19 survival survival NN cord-333405-ji58jbct 8 20 . . . cord-333405-ji58jbct 9 1 They -PRON- PRP cord-333405-ji58jbct 9 2 remain remain VBP cord-333405-ji58jbct 9 3 among among IN cord-333405-ji58jbct 9 4 the the DT cord-333405-ji58jbct 9 5 leading lead VBG cord-333405-ji58jbct 9 6 causes cause NNS cord-333405-ji58jbct 9 7 of of IN cord-333405-ji58jbct 9 8 death death NN cord-333405-ji58jbct 9 9 and and CC cord-333405-ji58jbct 9 10 disability disability NN cord-333405-ji58jbct 9 11 worldwide worldwide RB cord-333405-ji58jbct 9 12 . . . cord-333405-ji58jbct 10 1 Against against IN cord-333405-ji58jbct 10 2 a a DT cord-333405-ji58jbct 10 3 constant constant JJ cord-333405-ji58jbct 10 4 background background NN cord-333405-ji58jbct 10 5 of of IN cord-333405-ji58jbct 10 6 established establish VBN cord-333405-ji58jbct 10 7 infections infection NNS cord-333405-ji58jbct 10 8 , , , cord-333405-ji58jbct 10 9 epidemics epidemic NNS cord-333405-ji58jbct 10 10 of of IN cord-333405-ji58jbct 10 11 new new JJ cord-333405-ji58jbct 10 12 and and CC cord-333405-ji58jbct 10 13 old old JJ cord-333405-ji58jbct 10 14 infectious infectious JJ cord-333405-ji58jbct 10 15 diseases disease NNS cord-333405-ji58jbct 10 16 periodically periodically RB cord-333405-ji58jbct 10 17 emerge emerge VBP cord-333405-ji58jbct 10 18 , , , cord-333405-ji58jbct 10 19 greatly greatly RB cord-333405-ji58jbct 10 20 magnifying magnify VBG cord-333405-ji58jbct 10 21 the the DT cord-333405-ji58jbct 10 22 global global JJ cord-333405-ji58jbct 10 23 burden burden NN cord-333405-ji58jbct 10 24 of of IN cord-333405-ji58jbct 10 25 infections infection NNS cord-333405-ji58jbct 10 26 . . . cord-333405-ji58jbct 11 1 Studies study NNS cord-333405-ji58jbct 11 2 of of IN cord-333405-ji58jbct 11 3 these these DT cord-333405-ji58jbct 11 4 emerging emerge VBG cord-333405-ji58jbct 11 5 infections infection NNS cord-333405-ji58jbct 11 6 reveal reveal VBP cord-333405-ji58jbct 11 7 the the DT cord-333405-ji58jbct 11 8 evolutionary evolutionary JJ cord-333405-ji58jbct 11 9 properties property NNS cord-333405-ji58jbct 11 10 of of IN cord-333405-ji58jbct 11 11 pathogenic pathogenic JJ cord-333405-ji58jbct 11 12 microorganisms microorganism NNS cord-333405-ji58jbct 11 13 and and CC cord-333405-ji58jbct 11 14 the the DT cord-333405-ji58jbct 11 15 dynamic dynamic JJ cord-333405-ji58jbct 11 16 relationships relationship NNS cord-333405-ji58jbct 11 17 between between IN cord-333405-ji58jbct 11 18 microorganisms microorganism NNS cord-333405-ji58jbct 11 19 , , , cord-333405-ji58jbct 11 20 their -PRON- PRP$ cord-333405-ji58jbct 11 21 hosts host NNS cord-333405-ji58jbct 11 22 and and CC cord-333405-ji58jbct 11 23 the the DT cord-333405-ji58jbct 11 24 environment environment NN cord-333405-ji58jbct 11 25 . . . cord-333405-ji58jbct 12 1 merging merge VBG cord-333405-ji58jbct 12 2 infections infection NNS cord-333405-ji58jbct 12 3 ( ( -LRB- cord-333405-ji58jbct 12 4 EIs EIs NNP cord-333405-ji58jbct 12 5 ) ) -RRB- cord-333405-ji58jbct 12 6 can can MD cord-333405-ji58jbct 12 7 be be VB cord-333405-ji58jbct 12 8 defined define VBN cord-333405-ji58jbct 12 9 as as IN cord-333405-ji58jbct 12 10 " " `` cord-333405-ji58jbct 12 11 infections infection NNS cord-333405-ji58jbct 12 12 that that WDT cord-333405-ji58jbct 12 13 have have VBP cord-333405-ji58jbct 12 14 newly newly RB cord-333405-ji58jbct 12 15 appeared appear VBN cord-333405-ji58jbct 12 16 in in IN cord-333405-ji58jbct 12 17 a a DT cord-333405-ji58jbct 12 18 population population NN cord-333405-ji58jbct 12 19 or or CC cord-333405-ji58jbct 12 20 have have VBP cord-333405-ji58jbct 12 21 existed exist VBN cord-333405-ji58jbct 12 22 previously previously RB cord-333405-ji58jbct 12 23 but but CC cord-333405-ji58jbct 12 24 are be VBP cord-333405-ji58jbct 12 25 rapidly rapidly RB cord-333405-ji58jbct 12 26 increasing increase VBG cord-333405-ji58jbct 12 27 in in IN cord-333405-ji58jbct 12 28 incidence incidence NN cord-333405-ji58jbct 12 29 or or CC cord-333405-ji58jbct 12 30 geographic geographic JJ cord-333405-ji58jbct 12 31 range range NN cord-333405-ji58jbct 12 32 " " '' cord-333405-ji58jbct 12 33 1 1 CD cord-333405-ji58jbct 12 34 . . . cord-333405-ji58jbct 13 1 EIs ei NNS cord-333405-ji58jbct 13 2 have have VBP cord-333405-ji58jbct 13 3 shaped shape VBN cord-333405-ji58jbct 13 4 the the DT cord-333405-ji58jbct 13 5 course course NN cord-333405-ji58jbct 13 6 of of IN cord-333405-ji58jbct 13 7 human human JJ cord-333405-ji58jbct 13 8 history history NN cord-333405-ji58jbct 13 9 and and CC cord-333405-ji58jbct 13 10 have have VBP cord-333405-ji58jbct 13 11 caused cause VBN cord-333405-ji58jbct 13 12 incalculable incalculable JJ cord-333405-ji58jbct 13 13 misery misery NN cord-333405-ji58jbct 13 14 and and CC cord-333405-ji58jbct 13 15 death death NN cord-333405-ji58jbct 13 16 . . . cord-333405-ji58jbct 14 1 In in IN cord-333405-ji58jbct 14 2 1981 1981 CD cord-333405-ji58jbct 14 3 , , , cord-333405-ji58jbct 14 4 a a DT cord-333405-ji58jbct 14 5 new new JJ cord-333405-ji58jbct 14 6 disease disease NN cord-333405-ji58jbct 14 7 -acquired -acquired JJ cord-333405-ji58jbct 14 8 immune immune JJ cord-333405-ji58jbct 14 9 deficiency deficiency NN cord-333405-ji58jbct 14 10 syndrome syndrome NN cord-333405-ji58jbct 14 11 ( ( -LRB- cord-333405-ji58jbct 14 12 AIDS AIDS NNP cord-333405-ji58jbct 14 13 ) ) -RRB- cord-333405-ji58jbct 14 14 -was -wa VBD cord-333405-ji58jbct 14 15 first first RB cord-333405-ji58jbct 14 16 recognized recognize VBN cord-333405-ji58jbct 14 17 . . . cord-333405-ji58jbct 15 1 As as IN cord-333405-ji58jbct 15 2 a a DT cord-333405-ji58jbct 15 3 global global JJ cord-333405-ji58jbct 15 4 killer killer NN cord-333405-ji58jbct 15 5 , , , cord-333405-ji58jbct 15 6 AIDS AIDS NNP cord-333405-ji58jbct 15 7 now now RB cord-333405-ji58jbct 15 8 threatens threaten VBZ cord-333405-ji58jbct 15 9 to to TO cord-333405-ji58jbct 15 10 surpass surpass VB cord-333405-ji58jbct 15 11 the the DT cord-333405-ji58jbct 15 12 Black Black NNP cord-333405-ji58jbct 15 13 Death Death NNP cord-333405-ji58jbct 15 14 of of IN cord-333405-ji58jbct 15 15 the the DT cord-333405-ji58jbct 15 16 fourteenth fourteenth JJ cord-333405-ji58jbct 15 17 century century NN cord-333405-ji58jbct 15 18 and and CC cord-333405-ji58jbct 15 19 the the DT cord-333405-ji58jbct 15 20 1918 1918 CD cord-333405-ji58jbct 15 21 - - SYM cord-333405-ji58jbct 15 22 1920 1920 CD cord-333405-ji58jbct 15 23 influenza influenza NN cord-333405-ji58jbct 15 24 pandemic pandemic NN cord-333405-ji58jbct 15 25 , , , cord-333405-ji58jbct 15 26 each each DT cord-333405-ji58jbct 15 27 of of IN cord-333405-ji58jbct 15 28 which which WDT cord-333405-ji58jbct 15 29 killed kill VBD cord-333405-ji58jbct 15 30 at at RB cord-333405-ji58jbct 15 31 least least JJS cord-333405-ji58jbct 15 32 50 50 CD cord-333405-ji58jbct 15 33 million million CD cord-333405-ji58jbct 15 34 people people NNS cord-333405-ji58jbct 15 35 2 2 CD cord-333405-ji58jbct 15 36 , , , cord-333405-ji58jbct 15 37 3 3 CD cord-333405-ji58jbct 15 38 . . . cord-333405-ji58jbct 16 1 Of of IN cord-333405-ji58jbct 16 2 the the DT cord-333405-ji58jbct 16 3 ' ' `` cord-333405-ji58jbct 16 4 newly newly RB cord-333405-ji58jbct 16 5 emerging emerge VBG cord-333405-ji58jbct 16 6 ' ' '' cord-333405-ji58jbct 16 7 and and CC cord-333405-ji58jbct 16 8 ' ' `` cord-333405-ji58jbct 16 9 re re IN cord-333405-ji58jbct 16 10 - - JJ cord-333405-ji58jbct 16 11 emerging emerge VBG cord-333405-ji58jbct 16 12 / / SYM cord-333405-ji58jbct 16 13 resurging resurge VBG cord-333405-ji58jbct 16 14 ' ' `` cord-333405-ji58jbct 16 15 diseases disease NNS cord-333405-ji58jbct 16 16 that that WDT cord-333405-ji58jbct 16 17 have have VBP cord-333405-ji58jbct 16 18 followed follow VBN cord-333405-ji58jbct 16 19 the the DT cord-333405-ji58jbct 16 20 appearance appearance NN cord-333405-ji58jbct 16 21 of of IN cord-333405-ji58jbct 16 22 AIDS AIDS NNP cord-333405-ji58jbct 16 23 ( ( -LRB- cord-333405-ji58jbct 16 24 Fig Fig NNP cord-333405-ji58jbct 16 25 . . . cord-333405-ji58jbct 16 26 1 1 CD cord-333405-ji58jbct 16 27 ) ) -RRB- cord-333405-ji58jbct 16 28 , , , cord-333405-ji58jbct 16 29 some some DT cord-333405-ji58jbct 16 30 have have VBP cord-333405-ji58jbct 16 31 been be VBN cord-333405-ji58jbct 16 32 minor minor JJ cord-333405-ji58jbct 16 33 curiosities curiosity NNS cord-333405-ji58jbct 16 34 , , , cord-333405-ji58jbct 16 35 such such JJ cord-333405-ji58jbct 16 36 as as IN cord-333405-ji58jbct 16 37 the the DT cord-333405-ji58jbct 16 38 2003 2003 CD cord-333405-ji58jbct 16 39 cases case NNS cord-333405-ji58jbct 16 40 of of IN cord-333405-ji58jbct 16 41 monkeypox monkeypox NN cord-333405-ji58jbct 16 42 imported import VBN cord-333405-ji58jbct 16 43 into into IN cord-333405-ji58jbct 16 44 the the DT cord-333405-ji58jbct 16 45 United United NNP cord-333405-ji58jbct 16 46 States States NNP cord-333405-ji58jbct 16 47 4 4 CD cord-333405-ji58jbct 16 48 , , , cord-333405-ji58jbct 16 49 whereas whereas IN cord-333405-ji58jbct 16 50 others other NNS cord-333405-ji58jbct 16 51 , , , cord-333405-ji58jbct 16 52 such such JJ cord-333405-ji58jbct 16 53 as as IN cord-333405-ji58jbct 16 54 severe severe JJ cord-333405-ji58jbct 16 55 acute acute JJ cord-333405-ji58jbct 16 56 respiratory respiratory JJ cord-333405-ji58jbct 16 57 syndrome syndrome NN cord-333405-ji58jbct 16 58 ( ( -LRB- cord-333405-ji58jbct 16 59 SARS SARS NNP cord-333405-ji58jbct 16 60 ) ) -RRB- cord-333405-ji58jbct 16 61 , , , cord-333405-ji58jbct 16 62 which which WDT cord-333405-ji58jbct 16 63 emerged emerge VBD cord-333405-ji58jbct 16 64 in in IN cord-333405-ji58jbct 16 65 the the DT cord-333405-ji58jbct 16 66 same same JJ cord-333405-ji58jbct 16 67 year year NN cord-333405-ji58jbct 16 68 5 5 CD cord-333405-ji58jbct 16 69 , , , cord-333405-ji58jbct 16 70 have have VBP cord-333405-ji58jbct 16 71 had have VBN cord-333405-ji58jbct 16 72 a a DT cord-333405-ji58jbct 16 73 worldwide worldwide JJ cord-333405-ji58jbct 16 74 impact impact NN cord-333405-ji58jbct 16 75 . . . cord-333405-ji58jbct 17 1 The the DT cord-333405-ji58jbct 17 2 2001 2001 CD cord-333405-ji58jbct 17 3 anthrax anthrax NN cord-333405-ji58jbct 17 4 bioterrorist bioterrorist NN cord-333405-ji58jbct 17 5 attack attack NN cord-333405-ji58jbct 17 6 in in IN cord-333405-ji58jbct 17 7 the the DT cord-333405-ji58jbct 17 8 United United NNP cord-333405-ji58jbct 17 9 States States NNP cord-333405-ji58jbct 17 10 6 6 CD cord-333405-ji58jbct 17 11 falls fall VBZ cord-333405-ji58jbct 17 12 into into IN cord-333405-ji58jbct 17 13 a a DT cord-333405-ji58jbct 17 14 third third JJ cord-333405-ji58jbct 17 15 category category NN cord-333405-ji58jbct 17 16 : : : cord-333405-ji58jbct 17 17 ' ' '' cord-333405-ji58jbct 17 18 deliberately deliberately RB cord-333405-ji58jbct 17 19 emerging emerge VBG cord-333405-ji58jbct 17 20 ' ' POS cord-333405-ji58jbct 17 21 diseases disease NNS cord-333405-ji58jbct 17 22 . . . cord-333405-ji58jbct 18 1 EIs EIs NNP cord-333405-ji58jbct 18 2 can can MD cord-333405-ji58jbct 18 3 be be VB cord-333405-ji58jbct 18 4 expected expect VBN cord-333405-ji58jbct 18 5 to to TO cord-333405-ji58jbct 18 6 remain remain VB cord-333405-ji58jbct 18 7 a a DT cord-333405-ji58jbct 18 8 considerable considerable JJ cord-333405-ji58jbct 18 9 challenge challenge NN cord-333405-ji58jbct 18 10 for for IN cord-333405-ji58jbct 18 11 the the DT cord-333405-ji58jbct 18 12 foreseeable foreseeable JJ cord-333405-ji58jbct 18 13 future future NN cord-333405-ji58jbct 18 14 . . . cord-333405-ji58jbct 19 1 Here here RB cord-333405-ji58jbct 19 2 we -PRON- PRP cord-333405-ji58jbct 19 3 examine examine VBP cord-333405-ji58jbct 19 4 the the DT cord-333405-ji58jbct 19 5 nature nature NN cord-333405-ji58jbct 19 6 and and CC cord-333405-ji58jbct 19 7 scope scope NN cord-333405-ji58jbct 19 8 of of IN cord-333405-ji58jbct 19 9 emerging emerge VBG cord-333405-ji58jbct 19 10 and and CC cord-333405-ji58jbct 19 11 reemerging reemerge VBG cord-333405-ji58jbct 19 12 microbial microbial JJ cord-333405-ji58jbct 19 13 threats threat NNS cord-333405-ji58jbct 19 14 , , , cord-333405-ji58jbct 19 15 and and CC cord-333405-ji58jbct 19 16 consider consider VB cord-333405-ji58jbct 19 17 methods method NNS cord-333405-ji58jbct 19 18 for for IN cord-333405-ji58jbct 19 19 their -PRON- PRP$ cord-333405-ji58jbct 19 20 control control NN cord-333405-ji58jbct 19 21 . . . cord-333405-ji58jbct 20 1 We -PRON- PRP cord-333405-ji58jbct 20 2 emphasize emphasize VBP cord-333405-ji58jbct 20 3 that that IN cord-333405-ji58jbct 20 4 emergence emergence NN cord-333405-ji58jbct 20 5 results result NNS cord-333405-ji58jbct 20 6 from from IN cord-333405-ji58jbct 20 7 dynamic dynamic JJ cord-333405-ji58jbct 20 8 interactions interaction NNS cord-333405-ji58jbct 20 9 between between IN cord-333405-ji58jbct 20 10 rapidly rapidly RB cord-333405-ji58jbct 20 11 evolving evolve VBG cord-333405-ji58jbct 20 12 infectious infectious JJ cord-333405-ji58jbct 20 13 agents agent NNS cord-333405-ji58jbct 20 14 and and CC cord-333405-ji58jbct 20 15 changes change NNS cord-333405-ji58jbct 20 16 in in IN cord-333405-ji58jbct 20 17 the the DT cord-333405-ji58jbct 20 18 environment environment NN cord-333405-ji58jbct 20 19 and and CC cord-333405-ji58jbct 20 20 in in IN cord-333405-ji58jbct 20 21 host host NN cord-333405-ji58jbct 20 22 behaviour behaviour NN cord-333405-ji58jbct 20 23 that that WDT cord-333405-ji58jbct 20 24 provide provide VBP cord-333405-ji58jbct 20 25 such such JJ cord-333405-ji58jbct 20 26 agents agent NNS cord-333405-ji58jbct 20 27 with with IN cord-333405-ji58jbct 20 28 favourable favourable JJ cord-333405-ji58jbct 20 29 new new JJ cord-333405-ji58jbct 20 30 ecological ecological JJ cord-333405-ji58jbct 20 31 niches niche NNS cord-333405-ji58jbct 20 32 . . . cord-333405-ji58jbct 21 1 About about RB cord-333405-ji58jbct 21 2 15 15 CD cord-333405-ji58jbct 21 3 million million CD cord-333405-ji58jbct 21 4 ( ( -LRB- cord-333405-ji58jbct 21 5 > > NFP cord-333405-ji58jbct 21 6 25 25 CD cord-333405-ji58jbct 21 7 % % NN cord-333405-ji58jbct 21 8 ) ) -RRB- cord-333405-ji58jbct 21 9 of of IN cord-333405-ji58jbct 21 10 57 57 CD cord-333405-ji58jbct 21 11 million million CD cord-333405-ji58jbct 21 12 annual annual JJ cord-333405-ji58jbct 21 13 deaths death NNS cord-333405-ji58jbct 21 14 worldwide worldwide RB cord-333405-ji58jbct 21 15 are be VBP cord-333405-ji58jbct 21 16 estimated estimate VBN cord-333405-ji58jbct 21 17 to to TO cord-333405-ji58jbct 21 18 be be VB cord-333405-ji58jbct 21 19 related relate VBN cord-333405-ji58jbct 21 20 directly directly RB cord-333405-ji58jbct 21 21 to to IN cord-333405-ji58jbct 21 22 infectious infectious JJ cord-333405-ji58jbct 21 23 diseases disease NNS cord-333405-ji58jbct 21 24 ; ; : cord-333405-ji58jbct 21 25 this this DT cord-333405-ji58jbct 21 26 figure figure NN cord-333405-ji58jbct 21 27 does do VBZ cord-333405-ji58jbct 21 28 not not RB cord-333405-ji58jbct 21 29 include include VB cord-333405-ji58jbct 21 30 the the DT cord-333405-ji58jbct 21 31 additional additional JJ cord-333405-ji58jbct 21 32 millions million NNS cord-333405-ji58jbct 21 33 of of IN cord-333405-ji58jbct 21 34 deaths death NNS cord-333405-ji58jbct 21 35 that that WDT cord-333405-ji58jbct 21 36 occur occur VBP cord-333405-ji58jbct 21 37 as as IN cord-333405-ji58jbct 21 38 a a DT cord-333405-ji58jbct 21 39 consequence consequence NN cord-333405-ji58jbct 21 40 of of IN cord-333405-ji58jbct 21 41 past past JJ cord-333405-ji58jbct 21 42 infections infection NNS cord-333405-ji58jbct 21 43 ( ( -LRB- cord-333405-ji58jbct 21 44 for for IN cord-333405-ji58jbct 21 45 example example NN cord-333405-ji58jbct 21 46 , , , cord-333405-ji58jbct 21 47 streptococcal streptococcal JJ cord-333405-ji58jbct 21 48 rheumatic rheumatic JJ cord-333405-ji58jbct 21 49 heart heart NN cord-333405-ji58jbct 21 50 disease disease NN cord-333405-ji58jbct 21 51 ) ) -RRB- cord-333405-ji58jbct 21 52 , , , cord-333405-ji58jbct 21 53 or or CC cord-333405-ji58jbct 21 54 because because IN cord-333405-ji58jbct 21 55 of of IN cord-333405-ji58jbct 21 56 complications complication NNS cord-333405-ji58jbct 21 57 associated associate VBN cord-333405-ji58jbct 21 58 with with IN cord-333405-ji58jbct 21 59 chronic chronic JJ cord-333405-ji58jbct 21 60 infections infection NNS cord-333405-ji58jbct 21 61 , , , cord-333405-ji58jbct 21 62 such such JJ cord-333405-ji58jbct 21 63 as as IN cord-333405-ji58jbct 21 64 liver liver NN cord-333405-ji58jbct 21 65 failure failure NN cord-333405-ji58jbct 21 66 and and CC cord-333405-ji58jbct 21 67 hepatocellular hepatocellular JJ cord-333405-ji58jbct 21 68 carcinoma carcinoma NN cord-333405-ji58jbct 21 69 in in IN cord-333405-ji58jbct 21 70 people people NNS cord-333405-ji58jbct 21 71 infected infect VBN cord-333405-ji58jbct 21 72 with with IN cord-333405-ji58jbct 21 73 hepatitis hepatitis NN cord-333405-ji58jbct 21 74 B B NNP cord-333405-ji58jbct 21 75 or or CC cord-333405-ji58jbct 21 76 C c NN cord-333405-ji58jbct 21 77 viruses virus NNS cord-333405-ji58jbct 21 78 7 7 CD cord-333405-ji58jbct 22 1 ( ( -LRB- cord-333405-ji58jbct 22 2 Fig Fig NNP cord-333405-ji58jbct 22 3 . . NNP cord-333405-ji58jbct 22 4 2 2 CD cord-333405-ji58jbct 22 5 ) ) -RRB- cord-333405-ji58jbct 22 6 . . . cord-333405-ji58jbct 23 1 The the DT cord-333405-ji58jbct 23 2 burden burden NN cord-333405-ji58jbct 23 3 of of IN cord-333405-ji58jbct 23 4 morbidity morbidity NN cord-333405-ji58jbct 23 5 ( ( -LRB- cord-333405-ji58jbct 23 6 ill ill JJ cord-333405-ji58jbct 23 7 health health NN cord-333405-ji58jbct 23 8 ) ) -RRB- cord-333405-ji58jbct 23 9 and and CC cord-333405-ji58jbct 23 10 mortality mortality NN cord-333405-ji58jbct 23 11 associated associate VBN cord-333405-ji58jbct 23 12 with with IN cord-333405-ji58jbct 23 13 infectious infectious JJ cord-333405-ji58jbct 23 14 diseases disease NNS cord-333405-ji58jbct 23 15 falls fall VBZ cord-333405-ji58jbct 23 16 most most RBS cord-333405-ji58jbct 23 17 heavily heavily RB cord-333405-ji58jbct 23 18 on on IN cord-333405-ji58jbct 23 19 people people NNS cord-333405-ji58jbct 23 20 in in IN cord-333405-ji58jbct 23 21 developing develop VBG cord-333405-ji58jbct 23 22 countries country NNS cord-333405-ji58jbct 23 23 8 8 CD cord-333405-ji58jbct 23 24 , , , cord-333405-ji58jbct 23 25 and and CC cord-333405-ji58jbct 23 26 particularly particularly RB cord-333405-ji58jbct 23 27 on on IN cord-333405-ji58jbct 23 28 infants infant NNS cord-333405-ji58jbct 23 29 and and CC cord-333405-ji58jbct 23 30 children child NNS cord-333405-ji58jbct 23 31 ( ( -LRB- cord-333405-ji58jbct 23 32 about about RB cord-333405-ji58jbct 23 33 three three CD cord-333405-ji58jbct 23 34 million million CD cord-333405-ji58jbct 23 35 children child NNS cord-333405-ji58jbct 23 36 die die VBP cord-333405-ji58jbct 23 37 each each DT cord-333405-ji58jbct 23 38 year year NN cord-333405-ji58jbct 23 39 from from IN cord-333405-ji58jbct 23 40 malaria malaria NN cord-333405-ji58jbct 23 41 and and CC cord-333405-ji58jbct 23 42 diarrhoeal diarrhoeal NN cord-333405-ji58jbct 23 43 diseases disease NNS cord-333405-ji58jbct 23 44 alone alone RB cord-333405-ji58jbct 23 45 7 7 CD cord-333405-ji58jbct 23 46 ) ) -RRB- cord-333405-ji58jbct 23 47 . . . cord-333405-ji58jbct 24 1 In in IN cord-333405-ji58jbct 24 2 developed develop VBN cord-333405-ji58jbct 24 3 nations nation NNS cord-333405-ji58jbct 24 4 , , , cord-333405-ji58jbct 24 5 infectious infectious JJ cord-333405-ji58jbct 24 6 disease disease NN cord-333405-ji58jbct 24 7 mortality mortality NN cord-333405-ji58jbct 24 8 disproportionately disproportionately RB cord-333405-ji58jbct 24 9 affects affect VBZ cord-333405-ji58jbct 24 10 indigenous indigenous JJ cord-333405-ji58jbct 24 11 and and CC cord-333405-ji58jbct 24 12 disadvantaged disadvantaged JJ cord-333405-ji58jbct 24 13 minorities minority NNS cord-333405-ji58jbct 24 14 9 9 CD cord-333405-ji58jbct 24 15 . . . cord-333405-ji58jbct 25 1 EIs ei NNS cord-333405-ji58jbct 25 2 have have VBP cord-333405-ji58jbct 25 3 been be VBN cord-333405-ji58jbct 25 4 familiar familiar JJ cord-333405-ji58jbct 25 5 threats threat NNS cord-333405-ji58jbct 25 6 since since IN cord-333405-ji58jbct 25 7 ancient ancient JJ cord-333405-ji58jbct 25 8 times time NNS cord-333405-ji58jbct 25 9 . . . cord-333405-ji58jbct 26 1 They -PRON- PRP cord-333405-ji58jbct 26 2 were be VBD cord-333405-ji58jbct 26 3 once once RB cord-333405-ji58jbct 26 4 identified identify VBN cord-333405-ji58jbct 26 5 by by IN cord-333405-ji58jbct 26 6 terms term NNS cord-333405-ji58jbct 26 7 such such JJ cord-333405-ji58jbct 26 8 as as IN cord-333405-ji58jbct 26 9 ȕșȓȖș ȕșȓȖș NNP cord-333405-ji58jbct 26 10 ȝ ȝ NNP cord-333405-ji58jbct 26 11 ( ( -LRB- cord-333405-ji58jbct 26 12 loimos loimos NNP cord-333405-ji58jbct 26 13 ) ) -RRB- cord-333405-ji58jbct 26 14 10 10 CD cord-333405-ji58jbct 26 15 , , , cord-333405-ji58jbct 26 16 and and CC cord-333405-ji58jbct 26 17 later later RB cord-333405-ji58jbct 26 18 as as IN cord-333405-ji58jbct 26 19 ' ' `` cord-333405-ji58jbct 26 20 pestilences pestilence NNS cord-333405-ji58jbct 26 21 ' ' '' cord-333405-ji58jbct 26 22 , , , cord-333405-ji58jbct 26 23 ' ' `` cord-333405-ji58jbct 26 24 pestes peste NNS cord-333405-ji58jbct 26 25 ' ' '' cord-333405-ji58jbct 26 26 , , , cord-333405-ji58jbct 26 27 ' ' `` cord-333405-ji58jbct 26 28 pests pest NNS cord-333405-ji58jbct 26 29 ' ' POS cord-333405-ji58jbct 26 30 and and CC cord-333405-ji58jbct 26 31 ' ' `` cord-333405-ji58jbct 26 32 plagues plague NNS cord-333405-ji58jbct 26 33 ' ' '' cord-333405-ji58jbct 26 34 . . . cord-333405-ji58jbct 27 1 Many many JJ cord-333405-ji58jbct 27 2 examples example NNS cord-333405-ji58jbct 27 3 can can MD cord-333405-ji58jbct 27 4 be be VB cord-333405-ji58jbct 27 5 cited cite VBN cord-333405-ji58jbct 27 6 in in IN cord-333405-ji58jbct 27 7 addition addition NN cord-333405-ji58jbct 27 8 to to IN cord-333405-ji58jbct 27 9 the the DT cord-333405-ji58jbct 27 10 Black Black NNP cord-333405-ji58jbct 27 11 Death Death NNP cord-333405-ji58jbct 27 12 and and CC cord-333405-ji58jbct 27 13 the the DT cord-333405-ji58jbct 27 14 1918 1918 CD cord-333405-ji58jbct 27 15 influenza influenza NN cord-333405-ji58jbct 27 16 pandemic pandemic NN cord-333405-ji58jbct 27 17 , , , cord-333405-ji58jbct 27 18 such such JJ cord-333405-ji58jbct 27 19 as as IN cord-333405-ji58jbct 27 20 certain certain JJ cord-333405-ji58jbct 27 21 biblical biblical JJ cord-333405-ji58jbct 27 22 pharaonic pharaonic JJ cord-333405-ji58jbct 27 23 plagues plague NNS cord-333405-ji58jbct 27 24 and and CC cord-333405-ji58jbct 27 25 the the DT cord-333405-ji58jbct 27 26 unidentified unidentified JJ cord-333405-ji58jbct 27 27 Plague Plague NNP cord-333405-ji58jbct 27 28 of of IN cord-333405-ji58jbct 27 29 Athens Athens NNP cord-333405-ji58jbct 27 30 , , , cord-333405-ji58jbct 27 31 which which WDT cord-333405-ji58jbct 27 32 heralded herald VBD cord-333405-ji58jbct 27 33 the the DT cord-333405-ji58jbct 27 34 end end NN cord-333405-ji58jbct 27 35 of of IN cord-333405-ji58jbct 27 36 Greece Greece NNP cord-333405-ji58jbct 27 37 's 's POS cord-333405-ji58jbct 27 38 Golden Golden NNP cord-333405-ji58jbct 27 39 Age Age NNP cord-333405-ji58jbct 27 40 11 11 CD cord-333405-ji58jbct 27 41 . . . cord-333405-ji58jbct 28 1 The the DT cord-333405-ji58jbct 28 2 Age Age NNP cord-333405-ji58jbct 28 3 of of IN cord-333405-ji58jbct 28 4 Discovery Discovery NNP cord-333405-ji58jbct 28 5 , , , cord-333405-ji58jbct 28 6 starting start VBG cord-333405-ji58jbct 28 7 in in IN cord-333405-ji58jbct 28 8 the the DT cord-333405-ji58jbct 28 9 fifteenth fifteenth JJ cord-333405-ji58jbct 28 10 century century NN cord-333405-ji58jbct 28 11 , , , cord-333405-ji58jbct 28 12 was be VBD cord-333405-ji58jbct 28 13 a a DT cord-333405-ji58jbct 28 14 particularly particularly RB cord-333405-ji58jbct 28 15 disastrous disastrous JJ cord-333405-ji58jbct 28 16 period period NN cord-333405-ji58jbct 28 17 with with IN cord-333405-ji58jbct 28 18 regard regard NN cord-333405-ji58jbct 28 19 to to IN cord-333405-ji58jbct 28 20 the the DT cord-333405-ji58jbct 28 21 spread spread NN cord-333405-ji58jbct 28 22 of of IN cord-333405-ji58jbct 28 23 infectious infectious JJ cord-333405-ji58jbct 28 24 diseases disease NNS cord-333405-ji58jbct 28 25 . . . cord-333405-ji58jbct 29 1 Importation importation NN cord-333405-ji58jbct 29 2 of of IN cord-333405-ji58jbct 29 3 smallpox smallpox NN cord-333405-ji58jbct 29 4 into into IN cord-333405-ji58jbct 29 5 Mexico Mexico NNP cord-333405-ji58jbct 29 6 caused cause VBD cord-333405-ji58jbct 29 7 10 10 CD cord-333405-ji58jbct 29 8 - - SYM cord-333405-ji58jbct 29 9 15 15 CD cord-333405-ji58jbct 29 10 million million CD cord-333405-ji58jbct 29 11 deaths death NNS cord-333405-ji58jbct 29 12 in in IN cord-333405-ji58jbct 29 13 1520 1520 CD cord-333405-ji58jbct 29 14 - - SYM cord-333405-ji58jbct 29 15 1521 1521 CD cord-333405-ji58jbct 29 16 , , , cord-333405-ji58jbct 29 17 effectively effectively RB cord-333405-ji58jbct 29 18 ending end VBG cord-333405-ji58jbct 29 19 Aztec aztec JJ cord-333405-ji58jbct 29 20 civilization civilization NN cord-333405-ji58jbct 29 21 12 12 CD cord-333405-ji58jbct 29 22 , , , cord-333405-ji58jbct 29 23 13 13 CD cord-333405-ji58jbct 29 24 . . . cord-333405-ji58jbct 30 1 Other other JJ cord-333405-ji58jbct 30 2 Amerindian amerindian JJ cord-333405-ji58jbct 30 3 and and CC cord-333405-ji58jbct 30 4 Pacific pacific JJ cord-333405-ji58jbct 30 5 civilizations civilization NNS cord-333405-ji58jbct 30 6 were be VBD cord-333405-ji58jbct 30 7 destroyed destroy VBN cord-333405-ji58jbct 30 8 by by IN cord-333405-ji58jbct 30 9 imported import VBN cord-333405-ji58jbct 30 10 smallpox smallpox NN cord-333405-ji58jbct 30 11 and and CC cord-333405-ji58jbct 30 12 measles measle NNS cord-333405-ji58jbct 30 13 [ [ -LRB- cord-333405-ji58jbct 30 14 13 13 CD cord-333405-ji58jbct 30 15 ] ] -RRB- cord-333405-ji58jbct 31 1 [ [ -LRB- cord-333405-ji58jbct 31 2 14 14 CD cord-333405-ji58jbct 31 3 ] ] -RRB- cord-333405-ji58jbct 32 1 [ [ -LRB- cord-333405-ji58jbct 32 2 15 15 CD cord-333405-ji58jbct 32 3 ] ] -RRB- cord-333405-ji58jbct 32 4 [ [ -LRB- cord-333405-ji58jbct 32 5 16 16 CD cord-333405-ji58jbct 32 6 ] ] -RRB- cord-333405-ji58jbct 32 7 [ [ -LRB- cord-333405-ji58jbct 32 8 17 17 CD cord-333405-ji58jbct 32 9 ] ] -RRB- cord-333405-ji58jbct 32 10 . . . cord-333405-ji58jbct 33 1 Historians historian NNS cord-333405-ji58jbct 33 2 have have VBP cord-333405-ji58jbct 33 3 referred refer VBN cord-333405-ji58jbct 33 4 to to IN cord-333405-ji58jbct 33 5 these these DT cord-333405-ji58jbct 33 6 events event NNS cord-333405-ji58jbct 33 7 as as IN cord-333405-ji58jbct 33 8 apocalypses apocalypse NNS cord-333405-ji58jbct 33 9 16 16 CD cord-333405-ji58jbct 33 10 and and CC cord-333405-ji58jbct 33 11 even even RB cord-333405-ji58jbct 33 12 as as IN cord-333405-ji58jbct 33 13 genocide genocide NN cord-333405-ji58jbct 33 14 15 15 CD cord-333405-ji58jbct 33 15 . . . cord-333405-ji58jbct 34 1 For for IN cord-333405-ji58jbct 34 2 centuries century NNS cord-333405-ji58jbct 34 3 , , , cord-333405-ji58jbct 34 4 mankind mankind NN cord-333405-ji58jbct 34 5 seemed seem VBD cord-333405-ji58jbct 34 6 helpless helpless JJ cord-333405-ji58jbct 34 7 against against IN cord-333405-ji58jbct 34 8 these these DT cord-333405-ji58jbct 34 9 sudden sudden JJ cord-333405-ji58jbct 34 10 epidemics epidemic NNS cord-333405-ji58jbct 34 11 . . . cord-333405-ji58jbct 35 1 But but CC cord-333405-ji58jbct 35 2 the the DT cord-333405-ji58jbct 35 3 establishment establishment NN cord-333405-ji58jbct 35 4 of of IN cord-333405-ji58jbct 35 5 the the DT cord-333405-ji58jbct 35 6 germ germ NN cord-333405-ji58jbct 35 7 theory theory NN cord-333405-ji58jbct 35 8 and and CC cord-333405-ji58jbct 35 9 the the DT cord-333405-ji58jbct 35 10 identification identification NN cord-333405-ji58jbct 35 11 of of IN cord-333405-ji58jbct 35 12 specific specific JJ cord-333405-ji58jbct 35 13 microbes microbe NNS cord-333405-ji58jbct 35 14 as as IN cord-333405-ji58jbct 35 15 the the DT cord-333405-ji58jbct 35 16 causative causative JJ cord-333405-ji58jbct 35 17 agents agent NNS cord-333405-ji58jbct 35 18 of of IN cord-333405-ji58jbct 35 19 a a DT cord-333405-ji58jbct 35 20 wide wide JJ cord-333405-ji58jbct 35 21 variety variety NN cord-333405-ji58jbct 35 22 of of IN cord-333405-ji58jbct 35 23 infectious infectious JJ cord-333405-ji58jbct 35 24 diseases disease NNS cord-333405-ji58jbct 35 25 [ [ -LRB- cord-333405-ji58jbct 35 26 18 18 CD cord-333405-ji58jbct 35 27 ] ] -RRB- cord-333405-ji58jbct 35 28 [ [ -LRB- cord-333405-ji58jbct 35 29 19 19 CD cord-333405-ji58jbct 35 30 ] ] -RRB- cord-333405-ji58jbct 35 31 [ [ -LRB- cord-333405-ji58jbct 35 32 20 20 CD cord-333405-ji58jbct 35 33 ] ] -RRB- cord-333405-ji58jbct 35 34 led lead VBN cord-333405-ji58jbct 35 35 to to IN cord-333405-ji58jbct 35 36 enormous enormous JJ cord-333405-ji58jbct 35 37 progress progress NN cord-333405-ji58jbct 35 38 , , , cord-333405-ji58jbct 35 39 notably notably RB cord-333405-ji58jbct 35 40 the the DT cord-333405-ji58jbct 35 41 development development NN cord-333405-ji58jbct 35 42 of of IN cord-333405-ji58jbct 35 43 vaccines vaccine NNS cord-333405-ji58jbct 35 44 and and CC cord-333405-ji58jbct 35 45 ultimately ultimately RB cord-333405-ji58jbct 35 46 of of IN cord-333405-ji58jbct 35 47 antimicrobials antimicrobial NNS cord-333405-ji58jbct 35 48 20 20 CD cord-333405-ji58jbct 35 49 . . . cord-333405-ji58jbct 36 1 In in IN cord-333405-ji58jbct 36 2 fact fact NN cord-333405-ji58jbct 36 3 , , , cord-333405-ji58jbct 36 4 the the DT cord-333405-ji58jbct 36 5 era era NN cord-333405-ji58jbct 36 6 of of IN cord-333405-ji58jbct 36 7 the the DT cord-333405-ji58jbct 36 8 identification identification NN cord-333405-ji58jbct 36 9 of of IN cord-333405-ji58jbct 36 10 microbes microbe NNS cord-333405-ji58jbct 36 11 had have VBD cord-333405-ji58jbct 36 12 barely barely RB cord-333405-ji58jbct 36 13 begun begin VBN cord-333405-ji58jbct 36 14 18 18 CD cord-333405-ji58jbct 36 15 when when WRB cord-333405-ji58jbct 36 16 optimists optimist NNS cord-333405-ji58jbct 36 17 at at IN cord-333405-ji58jbct 36 18 the the DT cord-333405-ji58jbct 36 19 end end NN cord-333405-ji58jbct 36 20 of of IN cord-333405-ji58jbct 36 21 the the DT cord-333405-ji58jbct 36 22 nineteenth nineteenth JJ cord-333405-ji58jbct 36 23 century century NN cord-333405-ji58jbct 36 24 predicted predict VBD cord-333405-ji58jbct 36 25 the the DT cord-333405-ji58jbct 36 26 eradication eradication NN cord-333405-ji58jbct 36 27 of of IN cord-333405-ji58jbct 36 28 infectious infectious JJ cord-333405-ji58jbct 36 29 diseases disease NNS cord-333405-ji58jbct 36 30 21 21 CD cord-333405-ji58jbct 36 31 . . . cord-333405-ji58jbct 37 1 By by IN cord-333405-ji58jbct 37 2 the the DT cord-333405-ji58jbct 37 3 1950s 1950 NNS cord-333405-ji58jbct 37 4 , , , cord-333405-ji58jbct 37 5 which which WDT cord-333405-ji58jbct 37 6 witnessed witness VBD cord-333405-ji58jbct 37 7 the the DT cord-333405-ji58jbct 37 8 widespread widespread JJ cord-333405-ji58jbct 37 9 use use NN cord-333405-ji58jbct 37 10 of of IN cord-333405-ji58jbct 37 11 penicillin penicillin NN cord-333405-ji58jbct 37 12 , , , cord-333405-ji58jbct 37 13 the the DT cord-333405-ji58jbct 37 14 development development NN cord-333405-ji58jbct 37 15 of of IN cord-333405-ji58jbct 37 16 polio polio NN cord-333405-ji58jbct 37 17 vaccines vaccine NNS cord-333405-ji58jbct 37 18 and and CC cord-333405-ji58jbct 37 19 the the DT cord-333405-ji58jbct 37 20 discovery discovery NN cord-333405-ji58jbct 37 21 of of IN cord-333405-ji58jbct 37 22 drugs drug NNS cord-333405-ji58jbct 37 23 for for IN cord-333405-ji58jbct 37 24 tuberculosis tuberculosis NN cord-333405-ji58jbct 37 25 , , , cord-333405-ji58jbct 37 26 complacency complacency NN cord-333405-ji58jbct 37 27 had have VBD cord-333405-ji58jbct 37 28 set set VBN cord-333405-ji58jbct 37 29 in in IN cord-333405-ji58jbct 37 30 22 22 CD cord-333405-ji58jbct 37 31 , , , cord-333405-ji58jbct 37 32 and and CC cord-333405-ji58jbct 37 33 in in IN cord-333405-ji58jbct 37 34 1967 1967 CD cord-333405-ji58jbct 37 35 , , , cord-333405-ji58jbct 37 36 the the DT cord-333405-ji58jbct 37 37 US US NNP cord-333405-ji58jbct 37 38 Surgeon Surgeon NNP cord-333405-ji58jbct 37 39 General General NNP cord-333405-ji58jbct 37 40 stated state VBD cord-333405-ji58jbct 37 41 that that IN cord-333405-ji58jbct 37 42 " " `` cord-333405-ji58jbct 37 43 the the DT cord-333405-ji58jbct 37 44 war war NN cord-333405-ji58jbct 37 45 against against IN cord-333405-ji58jbct 37 46 infectious infectious JJ cord-333405-ji58jbct 37 47 diseases disease NNS cord-333405-ji58jbct 37 48 has have VBZ cord-333405-ji58jbct 37 49 been be VBN cord-333405-ji58jbct 37 50 won win VBN cord-333405-ji58jbct 37 51 " " `` cord-333405-ji58jbct 37 52 23 23 CD cord-333405-ji58jbct 37 53 . . . cord-333405-ji58jbct 38 1 Some some DT cord-333405-ji58jbct 38 2 experts expert NNS cord-333405-ji58jbct 38 3 remained remain VBD cord-333405-ji58jbct 38 4 sceptical sceptical JJ cord-333405-ji58jbct 38 5 , , , cord-333405-ji58jbct 38 6 aware aware JJ cord-333405-ji58jbct 38 7 of of IN cord-333405-ji58jbct 38 8 recurrent recurrent JJ cord-333405-ji58jbct 38 9 lessons lesson NNS cord-333405-ji58jbct 38 10 from from IN cord-333405-ji58jbct 38 11 history history NN cord-333405-ji58jbct 38 12 . . . cord-333405-ji58jbct 39 1 They -PRON- PRP cord-333405-ji58jbct 39 2 were be VBD cord-333405-ji58jbct 39 3 less less RBR cord-333405-ji58jbct 39 4 persuaded persuade VBN cord-333405-ji58jbct 39 5 by by IN cord-333405-ji58jbct 39 6 successes success NNS cord-333405-ji58jbct 39 7 than than IN cord-333405-ji58jbct 39 8 alarmed alarm VBN cord-333405-ji58jbct 39 9 by by IN cord-333405-ji58jbct 39 10 failures failure NNS cord-333405-ji58jbct 39 11 such such JJ cord-333405-ji58jbct 39 12 as as IN cord-333405-ji58jbct 39 13 the the DT cord-333405-ji58jbct 39 14 lack lack NN cord-333405-ji58jbct 39 15 of of IN cord-333405-ji58jbct 39 16 progress progress NN cord-333405-ji58jbct 39 17 against against IN cord-333405-ji58jbct 39 18 infections infection NNS cord-333405-ji58jbct 39 19 in in IN cord-333405-ji58jbct 39 20 the the DT cord-333405-ji58jbct 39 21 developing develop VBG cord-333405-ji58jbct 39 22 world world NN cord-333405-ji58jbct 39 23 and and CC cord-333405-ji58jbct 39 24 the the DT cord-333405-ji58jbct 39 25 global global JJ cord-333405-ji58jbct 39 26 spread spread NN cord-333405-ji58jbct 39 27 of of IN cord-333405-ji58jbct 39 28 antimicrobial antimicrobial JJ cord-333405-ji58jbct 39 29 resistance resistance NN cord-333405-ji58jbct 39 30 . . . cord-333405-ji58jbct 40 1 Richard Richard NNP cord-333405-ji58jbct 40 2 Krause Krause NNP cord-333405-ji58jbct 40 3 , , , cord-333405-ji58jbct 40 4 then then RB cord-333405-ji58jbct 40 5 the the DT cord-333405-ji58jbct 40 6 director director NN cord-333405-ji58jbct 40 7 of of IN cord-333405-ji58jbct 40 8 the the DT cord-333405-ji58jbct 40 9 US US NNP cord-333405-ji58jbct 40 10 National National NNP cord-333405-ji58jbct 40 11 Institute Institute NNP cord-333405-ji58jbct 40 12 of of IN cord-333405-ji58jbct 40 13 Allergy Allergy NNP cord-333405-ji58jbct 40 14 and and CC cord-333405-ji58jbct 40 15 Infectious Infectious NNP cord-333405-ji58jbct 40 16 Diseases Diseases NNPS cord-333405-ji58jbct 40 17 , , , cord-333405-ji58jbct 40 18 warned warn VBD cord-333405-ji58jbct 40 19 in in IN cord-333405-ji58jbct 40 20 1981 1981 CD cord-333405-ji58jbct 40 21 ( ( -LRB- cord-333405-ji58jbct 40 22 ref ref NN cord-333405-ji58jbct 40 23 . . . cord-333405-ji58jbct 41 1 24 24 LS cord-333405-ji58jbct 41 2 ) ) -RRB- cord-333405-ji58jbct 41 3 that that IN cord-333405-ji58jbct 41 4 microbial microbial JJ cord-333405-ji58jbct 41 5 diversity diversity NN cord-333405-ji58jbct 41 6 and and CC cord-333405-ji58jbct 41 7 evolutionary evolutionary JJ cord-333405-ji58jbct 41 8 vigour vigour NN cord-333405-ji58jbct 41 9 were be VBD cord-333405-ji58jbct 41 10 still still RB cord-333405-ji58jbct 41 11 dynamic dynamic JJ cord-333405-ji58jbct 41 12 forces force NNS cord-333405-ji58jbct 41 13 threatening threaten VBG cord-333405-ji58jbct 41 14 mankind mankind NN cord-333405-ji58jbct 41 15 . . . cord-333405-ji58jbct 42 1 As as IN cord-333405-ji58jbct 42 2 Krause Krause NNP cord-333405-ji58jbct 42 3 was be VBD cord-333405-ji58jbct 42 4 completing complete VBG cord-333405-ji58jbct 42 5 his -PRON- PRP$ cord-333405-ji58jbct 42 6 book book NN cord-333405-ji58jbct 42 7 The the DT cord-333405-ji58jbct 42 8 Restless Restless NNP cord-333405-ji58jbct 42 9 Tide Tide NNP cord-333405-ji58jbct 42 10 24 24 CD cord-333405-ji58jbct 42 11 , , , cord-333405-ji58jbct 42 12 AIDS AIDS NNP cord-333405-ji58jbct 42 13 -one -one : cord-333405-ji58jbct 42 14 of of IN cord-333405-ji58jbct 42 15 history history NN cord-333405-ji58jbct 42 16 's 's POS cord-333405-ji58jbct 42 17 most most RBS cord-333405-ji58jbct 42 18 devastating devastating JJ cord-333405-ji58jbct 42 19 pandemics pandemic NNS cord-333405-ji58jbct 42 20 -was -was : cord-333405-ji58jbct 42 21 already already RB cord-333405-ji58jbct 42 22 insidiously insidiously RB cord-333405-ji58jbct 42 23 emerging emerge VBG cord-333405-ji58jbct 42 24 . . . cord-333405-ji58jbct 43 1 The the DT cord-333405-ji58jbct 43 2 emergence emergence NN cord-333405-ji58jbct 43 3 of of IN cord-333405-ji58jbct 43 4 AIDS AIDS NNP cord-333405-ji58jbct 43 5 led lead VBD cord-333405-ji58jbct 43 6 to to IN cord-333405-ji58jbct 43 7 renewed renew VBN cord-333405-ji58jbct 43 8 appreciation appreciation NN cord-333405-ji58jbct 43 9 of of IN cord-333405-ji58jbct 43 10 the the DT cord-333405-ji58jbct 43 11 inevitability inevitability NN cord-333405-ji58jbct 43 12 and and CC cord-333405-ji58jbct 43 13 consequences consequence NNS cord-333405-ji58jbct 43 14 of of IN cord-333405-ji58jbct 43 15 the the DT cord-333405-ji58jbct 43 16 emergence emergence NN cord-333405-ji58jbct 43 17 of of IN cord-333405-ji58jbct 43 18 infectious infectious JJ cord-333405-ji58jbct 43 19 diseases disease NNS cord-333405-ji58jbct 43 20 [ [ -LRB- cord-333405-ji58jbct 43 21 25 25 CD cord-333405-ji58jbct 43 22 ] ] -RRB- cord-333405-ji58jbct 43 23 [ [ -LRB- cord-333405-ji58jbct 43 24 26 26 CD cord-333405-ji58jbct 43 25 ] ] -RRB- cord-333405-ji58jbct 43 26 [ [ -LRB- cord-333405-ji58jbct 43 27 27 27 CD cord-333405-ji58jbct 43 28 ] ] -RRB- cord-333405-ji58jbct 44 1 [ [ -LRB- cord-333405-ji58jbct 44 2 28 28 CD cord-333405-ji58jbct 44 3 ] ] -RRB- cord-333405-ji58jbct 44 4 [ [ -LRB- cord-333405-ji58jbct 44 5 29 29 CD cord-333405-ji58jbct 44 6 ] ] -RRB- cord-333405-ji58jbct 44 7 [ [ -LRB- cord-333405-ji58jbct 44 8 30 30 CD cord-333405-ji58jbct 44 9 ] ] -RRB- cord-333405-ji58jbct 44 10 [ [ -LRB- cord-333405-ji58jbct 44 11 31 31 CD cord-333405-ji58jbct 44 12 ] ] -RRB- cord-333405-ji58jbct 44 13 . . . cord-333405-ji58jbct 45 1 In in IN cord-333405-ji58jbct 45 2 the the DT cord-333405-ji58jbct 45 3 past past JJ cord-333405-ji58jbct 45 4 25 25 CD cord-333405-ji58jbct 45 5 years year NNS cord-333405-ji58jbct 45 6 , , , cord-333405-ji58jbct 45 7 some some DT cord-333405-ji58jbct 45 8 of of IN cord-333405-ji58jbct 45 9 the the DT cord-333405-ji58jbct 45 10 factors factor NNS cord-333405-ji58jbct 45 11 that that WDT cord-333405-ji58jbct 45 12 resulted result VBD cord-333405-ji58jbct 45 13 in in IN cord-333405-ji58jbct 45 14 AIDS AIDS NNP cord-333405-ji58jbct 45 15 have have VBP cord-333405-ji58jbct 45 16 also also RB cord-333405-ji58jbct 45 17 led lead VBN cord-333405-ji58jbct 45 18 to to IN cord-333405-ji58jbct 45 19 re re NNS cord-333405-ji58jbct 45 20 - - NNS cord-333405-ji58jbct 45 21 emergences emergence NNS cord-333405-ji58jbct 45 22 of of IN cord-333405-ji58jbct 45 23 historically historically RB cord-333405-ji58jbct 45 24 important important JJ cord-333405-ji58jbct 45 25 diseases disease NNS cord-333405-ji58jbct 45 26 such such JJ cord-333405-ji58jbct 45 27 as as IN cord-333405-ji58jbct 45 28 cholera cholera NN cord-333405-ji58jbct 45 29 , , , cord-333405-ji58jbct 45 30 diphtheria diphtheria NN cord-333405-ji58jbct 45 31 , , , cord-333405-ji58jbct 45 32 trench trench NN cord-333405-ji58jbct 45 33 fever fever NN cord-333405-ji58jbct 45 34 and and CC cord-333405-ji58jbct 45 35 plague plague NN cord-333405-ji58jbct 45 36 . . . cord-333405-ji58jbct 46 1 Many many JJ cord-333405-ji58jbct 46 2 re re NNS cord-333405-ji58jbct 46 3 - - NNS cord-333405-ji58jbct 46 4 emergences emergence NNS cord-333405-ji58jbct 46 5 have have VBP cord-333405-ji58jbct 46 6 been be VBN cord-333405-ji58jbct 46 7 catalysed catalyse VBN cord-333405-ji58jbct 46 8 by by IN cord-333405-ji58jbct 46 9 wars war NNS cord-333405-ji58jbct 46 10 , , , cord-333405-ji58jbct 46 11 loss loss NN cord-333405-ji58jbct 46 12 of of IN cord-333405-ji58jbct 46 13 social social JJ cord-333405-ji58jbct 46 14 cohesion cohesion NN cord-333405-ji58jbct 46 15 , , , cord-333405-ji58jbct 46 16 and and CC cord-333405-ji58jbct 46 17 natural natural JJ cord-333405-ji58jbct 46 18 disasters disaster NNS cord-333405-ji58jbct 46 19 such such JJ cord-333405-ji58jbct 46 20 as as IN cord-333405-ji58jbct 46 21 earthquakes earthquake NNS cord-333405-ji58jbct 46 22 and and CC cord-333405-ji58jbct 46 23 floods flood NNS cord-333405-ji58jbct 46 24 , , , cord-333405-ji58jbct 46 25 indicating indicate VBG cord-333405-ji58jbct 46 26 the the DT cord-333405-ji58jbct 46 27 importance importance NN cord-333405-ji58jbct 46 28 not not RB cord-333405-ji58jbct 46 29 only only RB cord-333405-ji58jbct 46 30 of of IN cord-333405-ji58jbct 46 31 microbial microbial JJ cord-333405-ji58jbct 46 32 and and CC cord-333405-ji58jbct 46 33 viral viral JJ cord-333405-ji58jbct 46 34 factors factor NNS cord-333405-ji58jbct 46 35 , , , cord-333405-ji58jbct 46 36 but but CC cord-333405-ji58jbct 46 37 also also RB cord-333405-ji58jbct 46 38 of of IN cord-333405-ji58jbct 46 39 social social JJ cord-333405-ji58jbct 46 40 and and CC cord-333405-ji58jbct 46 41 environmental environmental JJ cord-333405-ji58jbct 46 42 determinants determinant NNS cord-333405-ji58jbct 46 43 [ [ -LRB- cord-333405-ji58jbct 46 44 25 25 CD cord-333405-ji58jbct 46 45 ] ] -RRB- cord-333405-ji58jbct 46 46 [ [ -LRB- cord-333405-ji58jbct 46 47 26 26 CD cord-333405-ji58jbct 46 48 ] ] -RRB- cord-333405-ji58jbct 46 49 [ [ -LRB- cord-333405-ji58jbct 46 50 27 27 CD cord-333405-ji58jbct 46 51 ] ] -RRB- cord-333405-ji58jbct 46 52 [ [ -LRB- cord-333405-ji58jbct 46 53 28 28 CD cord-333405-ji58jbct 46 54 ] ] -RRB- cord-333405-ji58jbct 46 55 [ [ -LRB- cord-333405-ji58jbct 46 56 29 29 CD cord-333405-ji58jbct 46 57 ] ] -RRB- cord-333405-ji58jbct 46 58 [ [ -LRB- cord-333405-ji58jbct 46 59 30 30 CD cord-333405-ji58jbct 46 60 ] ] -RRB- cord-333405-ji58jbct 46 61 [ [ -LRB- cord-333405-ji58jbct 46 62 31 31 CD cord-333405-ji58jbct 46 63 ] ] -RRB- cord-333405-ji58jbct 46 64 . . . cord-333405-ji58jbct 47 1 The the DT cord-333405-ji58jbct 47 2 challenge challenge NN cord-333405-ji58jbct 47 3 of of IN cord-333405-ji58jbct 47 4 emerging emerge VBG cord-333405-ji58jbct 47 5 and and CC cord-333405-ji58jbct 47 6 re re VB cord-333405-ji58jbct 47 7 - - JJ cord-333405-ji58jbct 47 8 emerging emerge VBG cord-333405-ji58jbct 47 9 infectious infectious JJ cord-333405-ji58jbct 47 10 diseases disease NNS cord-333405-ji58jbct 48 1 The the DT cord-333405-ji58jbct 48 2 classification classification NN cord-333405-ji58jbct 48 3 of of IN cord-333405-ji58jbct 48 4 EIs EIs NNP cord-333405-ji58jbct 48 5 as as IN cord-333405-ji58jbct 48 6 ' ' '' cord-333405-ji58jbct 48 7 newly newly RB cord-333405-ji58jbct 48 8 emerging emerge VBG cord-333405-ji58jbct 48 9 ' ' '' cord-333405-ji58jbct 48 10 , , , cord-333405-ji58jbct 48 11 ' ' '' cord-333405-ji58jbct 48 12 re re IN cord-333405-ji58jbct 48 13 - - JJ cord-333405-ji58jbct 48 14 emerging emerge VBG cord-333405-ji58jbct 48 15 / / SYM cord-333405-ji58jbct 48 16 resurging resurge VBG cord-333405-ji58jbct 48 17 ' ' '' cord-333405-ji58jbct 48 18 or or CC cord-333405-ji58jbct 48 19 ' ' '' cord-333405-ji58jbct 48 20 deliberately deliberately RB cord-333405-ji58jbct 48 21 emerging emerge VBG cord-333405-ji58jbct 48 22 ' ' '' cord-333405-ji58jbct 48 23 is be VBZ cord-333405-ji58jbct 48 24 useful useful JJ cord-333405-ji58jbct 48 25 because because IN cord-333405-ji58jbct 48 26 the the DT cord-333405-ji58jbct 48 27 underlying underlie VBG cord-333405-ji58jbct 48 28 causes cause NNS cord-333405-ji58jbct 48 29 of of IN cord-333405-ji58jbct 48 30 emergence emergence NN cord-333405-ji58jbct 48 31 and and CC cord-333405-ji58jbct 48 32 the the DT cord-333405-ji58jbct 48 33 optimal optimal JJ cord-333405-ji58jbct 48 34 prevention prevention NN cord-333405-ji58jbct 48 35 or or CC cord-333405-ji58jbct 48 36 control control NN cord-333405-ji58jbct 48 37 responses response NNS cord-333405-ji58jbct 48 38 frequently frequently RB cord-333405-ji58jbct 48 39 differ differ VBP cord-333405-ji58jbct 48 40 between between IN cord-333405-ji58jbct 48 41 the the DT cord-333405-ji58jbct 48 42 groups group NNS cord-333405-ji58jbct 48 43 . . . cord-333405-ji58jbct 49 1 Newly newly RB cord-333405-ji58jbct 49 2 emerging emerge VBG cord-333405-ji58jbct 49 3 infections infection NNS cord-333405-ji58jbct 49 4 are be VBP cord-333405-ji58jbct 49 5 those those DT cord-333405-ji58jbct 49 6 that that WDT cord-333405-ji58jbct 49 7 have have VBP cord-333405-ji58jbct 49 8 not not RB cord-333405-ji58jbct 49 9 previously previously RB cord-333405-ji58jbct 49 10 been be VBN cord-333405-ji58jbct 49 11 recognized recognize VBN cord-333405-ji58jbct 49 12 in in IN cord-333405-ji58jbct 49 13 man man NN cord-333405-ji58jbct 49 14 . . . cord-333405-ji58jbct 50 1 Many many JJ cord-333405-ji58jbct 50 2 diverse diverse JJ cord-333405-ji58jbct 50 3 factors factor NNS cord-333405-ji58jbct 50 4 contribute contribute VBP cord-333405-ji58jbct 50 5 to to IN cord-333405-ji58jbct 50 6 their -PRON- PRP$ cord-333405-ji58jbct 50 7 emergences emergence NNS cord-333405-ji58jbct 50 8 ( ( -LRB- cord-333405-ji58jbct 50 9 see see VB cord-333405-ji58jbct 50 10 Box Box NNP cord-333405-ji58jbct 50 11 1 1 CD cord-333405-ji58jbct 50 12 ) ) -RRB- cord-333405-ji58jbct 50 13 ; ; : cord-333405-ji58jbct 50 14 these these DT cord-333405-ji58jbct 50 15 include include VBP cord-333405-ji58jbct 50 16 microbial microbial JJ cord-333405-ji58jbct 50 17 genetic genetic JJ cord-333405-ji58jbct 50 18 mutation mutation NN cord-333405-ji58jbct 50 19 and and CC cord-333405-ji58jbct 50 20 viral viral JJ cord-333405-ji58jbct 50 21 genetic genetic JJ cord-333405-ji58jbct 50 22 recombination recombination NN cord-333405-ji58jbct 50 23 or or CC cord-333405-ji58jbct 50 24 reassortment reassortment NN cord-333405-ji58jbct 50 25 , , , cord-333405-ji58jbct 50 26 changes change NNS cord-333405-ji58jbct 50 27 in in IN cord-333405-ji58jbct 50 28 populations population NNS cord-333405-ji58jbct 50 29 of of IN cord-333405-ji58jbct 50 30 reservoir reservoir NN cord-333405-ji58jbct 50 31 hosts host NNS cord-333405-ji58jbct 50 32 or or CC cord-333405-ji58jbct 50 33 intermediate intermediate JJ cord-333405-ji58jbct 50 34 insect insect NN cord-333405-ji58jbct 50 35 vectors vector NNS cord-333405-ji58jbct 50 36 , , , cord-333405-ji58jbct 50 37 microbial microbial JJ cord-333405-ji58jbct 50 38 switching switching NN cord-333405-ji58jbct 50 39 from from IN cord-333405-ji58jbct 50 40 animal animal NN cord-333405-ji58jbct 50 41 to to IN cord-333405-ji58jbct 50 42 human human JJ cord-333405-ji58jbct 50 43 hosts host NNS cord-333405-ji58jbct 50 44 , , , cord-333405-ji58jbct 50 45 human human JJ cord-333405-ji58jbct 50 46 behavioural behavioural JJ cord-333405-ji58jbct 50 47 changes change NNS cord-333405-ji58jbct 50 48 ( ( -LRB- cord-333405-ji58jbct 50 49 notably notably RB cord-333405-ji58jbct 50 50 human human JJ cord-333405-ji58jbct 50 51 movement movement NN cord-333405-ji58jbct 50 52 and and CC cord-333405-ji58jbct 50 53 urbanization urbanization NN cord-333405-ji58jbct 50 54 ) ) -RRB- cord-333405-ji58jbct 50 55 , , , cord-333405-ji58jbct 50 56 and and CC cord-333405-ji58jbct 50 57 environmental environmental JJ cord-333405-ji58jbct 50 58 factors factor NNS cord-333405-ji58jbct 50 59 . . . cord-333405-ji58jbct 51 1 These these DT cord-333405-ji58jbct 51 2 numerous numerous JJ cord-333405-ji58jbct 51 3 microbial microbial NN cord-333405-ji58jbct 51 4 , , , cord-333405-ji58jbct 51 5 host host NN cord-333405-ji58jbct 51 6 and and CC cord-333405-ji58jbct 51 7 environmental environmental JJ cord-333405-ji58jbct 51 8 factors factor NNS cord-333405-ji58jbct 51 9 interact interact VBP cord-333405-ji58jbct 51 10 to to TO cord-333405-ji58jbct 51 11 create create VB cord-333405-ji58jbct 51 12 opportunities opportunity NNS cord-333405-ji58jbct 51 13 for for IN cord-333405-ji58jbct 51 14 infectious infectious JJ cord-333405-ji58jbct 51 15 agents agent NNS cord-333405-ji58jbct 51 16 to to TO cord-333405-ji58jbct 51 17 evolve evolve VB cord-333405-ji58jbct 51 18 into into IN cord-333405-ji58jbct 51 19 new new JJ cord-333405-ji58jbct 51 20 ecological ecological JJ cord-333405-ji58jbct 51 21 niches niche NNS cord-333405-ji58jbct 51 22 , , , cord-333405-ji58jbct 51 23 reach reach VB cord-333405-ji58jbct 51 24 and and CC cord-333405-ji58jbct 51 25 adapt adapt VB cord-333405-ji58jbct 51 26 to to IN cord-333405-ji58jbct 51 27 new new JJ cord-333405-ji58jbct 51 28 hosts host NNS cord-333405-ji58jbct 51 29 , , , cord-333405-ji58jbct 51 30 and and CC cord-333405-ji58jbct 51 31 spread spread VBD cord-333405-ji58jbct 51 32 more more RBR cord-333405-ji58jbct 51 33 easily easily RB cord-333405-ji58jbct 51 34 between between IN cord-333405-ji58jbct 51 35 them -PRON- PRP cord-333405-ji58jbct 51 36 . . . cord-333405-ji58jbct 52 1 Any any DT cord-333405-ji58jbct 52 2 discussion discussion NN cord-333405-ji58jbct 52 3 of of IN cord-333405-ji58jbct 52 4 recent recent JJ cord-333405-ji58jbct 52 5 EIs ei NNS cord-333405-ji58jbct 52 6 must must MD cord-333405-ji58jbct 52 7 begin begin VB cord-333405-ji58jbct 52 8 with with IN cord-333405-ji58jbct 52 9 the the DT cord-333405-ji58jbct 52 10 human human JJ cord-333405-ji58jbct 52 11 immunodeficiency immunodeficiency NN cord-333405-ji58jbct 52 12 virus virus NN cord-333405-ji58jbct 52 13 ( ( -LRB- cord-333405-ji58jbct 52 14 HIV HIV NNP cord-333405-ji58jbct 52 15 ) ) -RRB- cord-333405-ji58jbct 52 16 that that WDT cord-333405-ji58jbct 52 17 causes cause VBZ cord-333405-ji58jbct 52 18 AIDS AIDS NNP cord-333405-ji58jbct 52 19 . . . cord-333405-ji58jbct 53 1 HIV HIV NNP cord-333405-ji58jbct 53 2 has have VBZ cord-333405-ji58jbct 53 3 so so RB cord-333405-ji58jbct 53 4 far far RB cord-333405-ji58jbct 53 5 infected infected JJ cord-333405-ji58jbct 53 6 more more JJR cord-333405-ji58jbct 53 7 than than IN cord-333405-ji58jbct 53 8 60 60 CD cord-333405-ji58jbct 53 9 million million CD cord-333405-ji58jbct 53 10 people people NNS cord-333405-ji58jbct 53 11 worldwide worldwide RB cord-333405-ji58jbct 53 12 33 33 CD cord-333405-ji58jbct 53 13 . . . cord-333405-ji58jbct 54 1 Before before IN cord-333405-ji58jbct 54 2 jumping jump VBG cord-333405-ji58jbct 54 3 to to IN cord-333405-ji58jbct 54 4 humans human NNS cord-333405-ji58jbct 54 5 an an DT cord-333405-ji58jbct 54 6 estimated estimate VBN cord-333405-ji58jbct 54 7 60 60 CD cord-333405-ji58jbct 54 8 - - SYM cord-333405-ji58jbct 54 9 70 70 CD cord-333405-ji58jbct 54 10 years year NNS cord-333405-ji58jbct 54 11 ago ago RB cord-333405-ji58jbct 54 12 34 34 CD cord-333405-ji58jbct 54 13 , , , cord-333405-ji58jbct 54 14 perhaps perhaps RB cord-333405-ji58jbct 54 15 as as IN cord-333405-ji58jbct 54 16 a a DT cord-333405-ji58jbct 54 17 consequence consequence NN cord-333405-ji58jbct 54 18 of of IN cord-333405-ji58jbct 54 19 the the DT cord-333405-ji58jbct 54 20 consumption consumption NN cord-333405-ji58jbct 54 21 of of IN cord-333405-ji58jbct 54 22 ' ' `` cord-333405-ji58jbct 54 23 bush bush NNP cord-333405-ji58jbct 54 24 meat meat NN cord-333405-ji58jbct 54 25 ' ' '' cord-333405-ji58jbct 54 26 from from IN cord-333405-ji58jbct 54 27 non non JJ cord-333405-ji58jbct 54 28 - - JJ cord-333405-ji58jbct 54 29 human human JJ cord-333405-ji58jbct 54 30 primates primate NNS cord-333405-ji58jbct 54 31 , , , cord-333405-ji58jbct 54 32 HIV-1 HIV-1 NNP cord-333405-ji58jbct 54 33 and and CC cord-333405-ji58jbct 54 34 HIV-2 HIV-2 NNP cord-333405-ji58jbct 54 35 had have VBD cord-333405-ji58jbct 54 36 ample ample JJ cord-333405-ji58jbct 54 37 opportunity opportunity NN cord-333405-ji58jbct 54 38 to to TO cord-333405-ji58jbct 54 39 evolve evolve VB cord-333405-ji58jbct 54 40 in in IN cord-333405-ji58jbct 54 41 hosts host NNS cord-333405-ji58jbct 54 42 that that WDT cord-333405-ji58jbct 54 43 were be VBD cord-333405-ji58jbct 54 44 genetically genetically RB cord-333405-ji58jbct 54 45 similar similar JJ cord-333405-ji58jbct 54 46 to to IN cord-333405-ji58jbct 54 47 man man NN cord-333405-ji58jbct 54 48 ( ( -LRB- cord-333405-ji58jbct 54 49 the the DT cord-333405-ji58jbct 54 50 chimpanzee chimpanzee NN cord-333405-ji58jbct 54 51 , , , cord-333405-ji58jbct 54 52 Pan Pan NNP cord-333405-ji58jbct 54 53 troglodytes troglodyte NNS cord-333405-ji58jbct 54 54 , , , cord-333405-ji58jbct 54 55 and and CC cord-333405-ji58jbct 54 56 the the DT cord-333405-ji58jbct 54 57 sooty sooty JJ cord-333405-ji58jbct 54 58 mangabey mangabey NN cord-333405-ji58jbct 54 59 , , , cord-333405-ji58jbct 54 60 Cercocebus Cercocebus NNP cord-333405-ji58jbct 54 61 atys atys NNP cord-333405-ji58jbct 54 62 ) ) -RRB- cord-333405-ji58jbct 54 63 . . . cord-333405-ji58jbct 55 1 But but CC cord-333405-ji58jbct 55 2 HIV HIV NNP cord-333405-ji58jbct 55 3 / / SYM cord-333405-ji58jbct 55 4 AIDS AIDS NNP cord-333405-ji58jbct 55 5 might may MD cord-333405-ji58jbct 55 6 never never RB cord-333405-ji58jbct 55 7 have have VB cord-333405-ji58jbct 55 8 emerged emerge VBN cord-333405-ji58jbct 55 9 had have VBD cord-333405-ji58jbct 55 10 it -PRON- PRP cord-333405-ji58jbct 55 11 not not RB cord-333405-ji58jbct 55 12 been be VBN cord-333405-ji58jbct 55 13 for for IN cord-333405-ji58jbct 55 14 disruptions disruption NNS cord-333405-ji58jbct 55 15 in in IN cord-333405-ji58jbct 55 16 the the DT cord-333405-ji58jbct 55 17 economic economic JJ cord-333405-ji58jbct 55 18 and and CC cord-333405-ji58jbct 55 19 social social JJ cord-333405-ji58jbct 55 20 infrastructure infrastructure NN cord-333405-ji58jbct 55 21 in in IN cord-333405-ji58jbct 55 22 post post JJ cord-333405-ji58jbct 55 23 - - JJ cord-333405-ji58jbct 55 24 colonial colonial JJ cord-333405-ji58jbct 55 25 sub sub NN cord-333405-ji58jbct 55 26 - - NNP cord-333405-ji58jbct 55 27 Saharan Saharan NNP cord-333405-ji58jbct 55 28 Africa Africa NNP cord-333405-ji58jbct 55 29 . . . cord-333405-ji58jbct 56 1 Increased increase VBN cord-333405-ji58jbct 56 2 travel travel NN cord-333405-ji58jbct 56 3 , , , cord-333405-ji58jbct 56 4 the the DT cord-333405-ji58jbct 56 5 movement movement NN cord-333405-ji58jbct 56 6 of of IN cord-333405-ji58jbct 56 7 rural rural JJ cord-333405-ji58jbct 56 8 populations population NNS cord-333405-ji58jbct 56 9 to to IN cord-333405-ji58jbct 56 10 large large JJ cord-333405-ji58jbct 56 11 cities city NNS cord-333405-ji58jbct 56 12 , , , cord-333405-ji58jbct 56 13 urban urban JJ cord-333405-ji58jbct 56 14 poverty poverty NN cord-333405-ji58jbct 56 15 and and CC cord-333405-ji58jbct 56 16 a a DT cord-333405-ji58jbct 56 17 weakening weakening NN cord-333405-ji58jbct 56 18 of of IN cord-333405-ji58jbct 56 19 family family NN cord-333405-ji58jbct 56 20 structure structure NN cord-333405-ji58jbct 56 21 all all DT cord-333405-ji58jbct 56 22 promoted promote VBD cord-333405-ji58jbct 56 23 sexual sexual JJ cord-333405-ji58jbct 56 24 practices practice NNS cord-333405-ji58jbct 56 25 , , , cord-333405-ji58jbct 56 26 such such JJ cord-333405-ji58jbct 56 27 as as IN cord-333405-ji58jbct 56 28 promiscuity promiscuity NN cord-333405-ji58jbct 56 29 and and CC cord-333405-ji58jbct 56 30 prostitution prostitution NN cord-333405-ji58jbct 56 31 , , , cord-333405-ji58jbct 56 32 that that WDT cord-333405-ji58jbct 56 33 facilitate facilitate VBP cord-333405-ji58jbct 56 34 HIV HIV NNP cord-333405-ji58jbct 56 35 transmission transmission NN cord-333405-ji58jbct 56 36 [ [ -LRB- cord-333405-ji58jbct 56 37 34 34 CD cord-333405-ji58jbct 56 38 ] ] -RRB- cord-333405-ji58jbct 56 39 [ [ -LRB- cord-333405-ji58jbct 56 40 35 35 CD cord-333405-ji58jbct 56 41 ] ] -RRB- cord-333405-ji58jbct 56 42 [ [ -LRB- cord-333405-ji58jbct 56 43 36 36 CD cord-333405-ji58jbct 56 44 ] ] -RRB- cord-333405-ji58jbct 56 45 [ [ -LRB- cord-333405-ji58jbct 56 46 37 37 CD cord-333405-ji58jbct 56 47 ] ] -RRB- cord-333405-ji58jbct 56 48 . . . cord-333405-ji58jbct 57 1 Such such JJ cord-333405-ji58jbct 57 2 complex complex JJ cord-333405-ji58jbct 57 3 interactions interaction NNS cord-333405-ji58jbct 57 4 between between IN cord-333405-ji58jbct 57 5 infectious infectious JJ cord-333405-ji58jbct 57 6 agents agent NNS cord-333405-ji58jbct 57 7 , , , cord-333405-ji58jbct 57 8 hosts host NNS cord-333405-ji58jbct 57 9 and and CC cord-333405-ji58jbct 57 10 the the DT cord-333405-ji58jbct 57 11 environment environment NN cord-333405-ji58jbct 57 12 are be VBP cord-333405-ji58jbct 57 13 not not RB cord-333405-ji58jbct 57 14 unique unique JJ cord-333405-ji58jbct 57 15 to to IN cord-333405-ji58jbct 57 16 the the DT cord-333405-ji58jbct 57 17 epidemiology epidemiology NN cord-333405-ji58jbct 57 18 of of IN cord-333405-ji58jbct 57 19 HIV HIV NNP cord-333405-ji58jbct 57 20 / / SYM cord-333405-ji58jbct 57 21 AIDS AIDS NNP cord-333405-ji58jbct 57 22 . . . cord-333405-ji58jbct 58 1 The the DT cord-333405-ji58jbct 58 2 examples example NNS cord-333405-ji58jbct 58 3 cited cite VBN cord-333405-ji58jbct 58 4 below below IN cord-333405-ji58jbct 58 5 further far RBR cord-333405-ji58jbct 58 6 illustrate illustrate VB cord-333405-ji58jbct 58 7 how how WRB cord-333405-ji58jbct 58 8 changes change NNS cord-333405-ji58jbct 58 9 in in IN cord-333405-ji58jbct 58 10 population population NN cord-333405-ji58jbct 58 11 density density NN cord-333405-ji58jbct 58 12 , , , cord-333405-ji58jbct 58 13 human human JJ cord-333405-ji58jbct 58 14 movements movement NNS cord-333405-ji58jbct 58 15 and and CC cord-333405-ji58jbct 58 16 the the DT cord-333405-ji58jbct 58 17 environment environment NN cord-333405-ji58jbct 58 18 interact interact VBP cord-333405-ji58jbct 58 19 to to TO cord-333405-ji58jbct 58 20 create create VB cord-333405-ji58jbct 58 21 ecological ecological JJ cord-333405-ji58jbct 58 22 niches niche NNS cord-333405-ji58jbct 58 23 that that WDT cord-333405-ji58jbct 58 24 facilitate facilitate VBP cord-333405-ji58jbct 58 25 microbial microbial JJ cord-333405-ji58jbct 58 26 or or CC cord-333405-ji58jbct 58 27 viral viral JJ cord-333405-ji58jbct 58 28 adaptation adaptation NN cord-333405-ji58jbct 58 29 . . . cord-333405-ji58jbct 59 1 Some some DT cord-333405-ji58jbct 59 2 infectious infectious JJ cord-333405-ji58jbct 59 3 agents agent NNS cord-333405-ji58jbct 59 4 that that WDT cord-333405-ji58jbct 59 5 have have VBP cord-333405-ji58jbct 59 6 adapted adapt VBN cord-333405-ji58jbct 59 7 to to IN cord-333405-ji58jbct 59 8 non non JJ cord-333405-ji58jbct 59 9 - - JJ cord-333405-ji58jbct 59 10 human human JJ cord-333405-ji58jbct 59 11 hosts host NNS cord-333405-ji58jbct 59 12 can can MD cord-333405-ji58jbct 59 13 jump jump VB cord-333405-ji58jbct 59 14 to to IN cord-333405-ji58jbct 59 15 humans human NNS cord-333405-ji58jbct 59 16 but but CC cord-333405-ji58jbct 59 17 , , , cord-333405-ji58jbct 59 18 unlike unlike IN cord-333405-ji58jbct 59 19 HIV HIV NNP cord-333405-ji58jbct 59 20 , , , cord-333405-ji58jbct 59 21 are be VBP cord-333405-ji58jbct 59 22 not not RB cord-333405-ji58jbct 59 23 generally generally RB cord-333405-ji58jbct 59 24 transmitted transmit VBN cord-333405-ji58jbct 59 25 from from IN cord-333405-ji58jbct 59 26 person person NN cord-333405-ji58jbct 59 27 to to IN cord-333405-ji58jbct 59 28 person person NN cord-333405-ji58jbct 59 29 , , , cord-333405-ji58jbct 59 30 achieving achieve VBG cord-333405-ji58jbct 59 31 only only RB cord-333405-ji58jbct 59 32 ' ' `` cord-333405-ji58jbct 59 33 dead dead JJ cord-333405-ji58jbct 59 34 end end NN cord-333405-ji58jbct 59 35 ' ' '' cord-333405-ji58jbct 59 36 transmission transmission NN cord-333405-ji58jbct 59 37 . . . cord-333405-ji58jbct 60 1 Infections infection NNS cord-333405-ji58jbct 60 2 in in IN cord-333405-ji58jbct 60 3 animals animal NNS cord-333405-ji58jbct 60 4 that that WDT cord-333405-ji58jbct 60 5 are be VBP cord-333405-ji58jbct 60 6 transmitted transmit VBN cord-333405-ji58jbct 60 7 to to IN cord-333405-ji58jbct 60 8 humans human NNS cord-333405-ji58jbct 60 9 ( ( -LRB- cord-333405-ji58jbct 60 10 zoonoses zoonosis NNS cord-333405-ji58jbct 60 11 ) ) -RRB- cord-333405-ji58jbct 60 12 , , , cord-333405-ji58jbct 60 13 and and CC cord-333405-ji58jbct 60 14 those those DT cord-333405-ji58jbct 60 15 transmitted transmit VBN cord-333405-ji58jbct 60 16 from from IN cord-333405-ji58jbct 60 17 one one CD cord-333405-ji58jbct 60 18 vertebrate vertebrate NN cord-333405-ji58jbct 60 19 to to IN cord-333405-ji58jbct 60 20 another another DT cord-333405-ji58jbct 60 21 by by IN cord-333405-ji58jbct 60 22 an an DT cord-333405-ji58jbct 60 23 arthropod arthropod JJ cord-333405-ji58jbct 60 24 vector vector NN cord-333405-ji58jbct 60 25 ( ( -LRB- cord-333405-ji58jbct 60 26 vector vector NN cord-333405-ji58jbct 60 27 - - HYPH cord-333405-ji58jbct 60 28 borne bear VBN cord-333405-ji58jbct 60 29 diseases disease NNS cord-333405-ji58jbct 60 30 ) ) -RRB- cord-333405-ji58jbct 60 31 , , , cord-333405-ji58jbct 60 32 have have VBP cord-333405-ji58jbct 60 33 repeatedly repeatedly RB cord-333405-ji58jbct 60 34 been be VBN cord-333405-ji58jbct 60 35 identified identify VBN cord-333405-ji58jbct 60 36 as as IN cord-333405-ji58jbct 60 37 ranking rank VBG cord-333405-ji58jbct 60 38 among among IN cord-333405-ji58jbct 60 39 the the DT cord-333405-ji58jbct 60 40 most most RBS cord-333405-ji58jbct 60 41 important important JJ cord-333405-ji58jbct 60 42 EIs ei NNS cord-333405-ji58jbct 60 43 25 25 CD cord-333405-ji58jbct 60 44 , , , cord-333405-ji58jbct 60 45 26 26 CD cord-333405-ji58jbct 60 46 . . . cord-333405-ji58jbct 61 1 Examples example NNS cord-333405-ji58jbct 61 2 include include VBP cord-333405-ji58jbct 61 3 the the DT cord-333405-ji58jbct 61 4 arenavirus arenavirus JJ cord-333405-ji58jbct 61 5 haemorrhagic haemorrhagic JJ cord-333405-ji58jbct 61 6 fevers fever NNS cord-333405-ji58jbct 61 7 ( ( -LRB- cord-333405-ji58jbct 61 8 Argentine argentine JJ cord-333405-ji58jbct 61 9 , , , cord-333405-ji58jbct 61 10 Bolivian bolivian JJ cord-333405-ji58jbct 61 11 , , , cord-333405-ji58jbct 61 12 Venezuelan Venezuelan NNP cord-333405-ji58jbct 61 13 and and CC cord-333405-ji58jbct 61 14 Lassa Lassa NNP cord-333405-ji58jbct 61 15 haemorrhagic haemorrhagic JJ cord-333405-ji58jbct 61 16 fevers fever NNS cord-333405-ji58jbct 61 17 ) ) -RRB- cord-333405-ji58jbct 61 18 and and CC cord-333405-ji58jbct 61 19 hantavirus hantavirus NN cord-333405-ji58jbct 61 20 pulmonary pulmonary JJ cord-333405-ji58jbct 61 21 syndrome syndrome NN cord-333405-ji58jbct 61 22 ( ( -LRB- cord-333405-ji58jbct 61 23 HPS HPS NNP cord-333405-ji58jbct 61 24 ) ) -RRB- cord-333405-ji58jbct 61 25 . . . cord-333405-ji58jbct 62 1 Viruses virus NNS cord-333405-ji58jbct 62 2 in in IN cord-333405-ji58jbct 62 3 these these DT cord-333405-ji58jbct 62 4 groups group NNS cord-333405-ji58jbct 62 5 have have VBP cord-333405-ji58jbct 62 6 co co VBN cord-333405-ji58jbct 62 7 - - VBN cord-333405-ji58jbct 62 8 evolved evolved JJ cord-333405-ji58jbct 62 9 with with IN cord-333405-ji58jbct 62 10 specific specific JJ cord-333405-ji58jbct 62 11 rodent rodent NN cord-333405-ji58jbct 62 12 species specie NNS cord-333405-ji58jbct 62 13 whose whose WP$ cord-333405-ji58jbct 62 14 contact contact NN cord-333405-ji58jbct 62 15 with with IN cord-333405-ji58jbct 62 16 humans human NNS cord-333405-ji58jbct 62 17 has have VBZ cord-333405-ji58jbct 62 18 increased increase VBN cord-333405-ji58jbct 62 19 as as IN cord-333405-ji58jbct 62 20 a a DT cord-333405-ji58jbct 62 21 result result NN cord-333405-ji58jbct 62 22 of of IN cord-333405-ji58jbct 62 23 modern modern JJ cord-333405-ji58jbct 62 24 environmental environmental JJ cord-333405-ji58jbct 62 25 and and CC cord-333405-ji58jbct 62 26 human human JJ cord-333405-ji58jbct 62 27 behavioural behavioural JJ cord-333405-ji58jbct 62 28 factors factor NNS cord-333405-ji58jbct 62 29 . . . cord-333405-ji58jbct 63 1 Farming farming NN cord-333405-ji58jbct 63 2 , , , cord-333405-ji58jbct 63 3 keeping keep VBG cord-333405-ji58jbct 63 4 domestic domestic JJ cord-333405-ji58jbct 63 5 pets pet NNS cord-333405-ji58jbct 63 6 , , , cord-333405-ji58jbct 63 7 hunting hunting NN cord-333405-ji58jbct 63 8 and and CC cord-333405-ji58jbct 63 9 camping camping NN cord-333405-ji58jbct 63 10 , , , cord-333405-ji58jbct 63 11 deforestation deforestation NN cord-333405-ji58jbct 63 12 and and CC cord-333405-ji58jbct 63 13 other other JJ cord-333405-ji58jbct 63 14 types type NNS cord-333405-ji58jbct 63 15 of of IN cord-333405-ji58jbct 63 16 habitat habitat NN cord-333405-ji58jbct 63 17 destruction destruction NN cord-333405-ji58jbct 63 18 all all DT cord-333405-ji58jbct 63 19 create create VBP cord-333405-ji58jbct 63 20 new new JJ cord-333405-ji58jbct 63 21 opportunities opportunity NNS cord-333405-ji58jbct 63 22 for for IN cord-333405-ji58jbct 63 23 such such JJ cord-333405-ji58jbct 63 24 infectious infectious JJ cord-333405-ji58jbct 63 25 agents agent NNS cord-333405-ji58jbct 63 26 to to TO cord-333405-ji58jbct 63 27 invade invade VB cord-333405-ji58jbct 63 28 human human JJ cord-333405-ji58jbct 63 29 hosts host NNS cord-333405-ji58jbct 63 30 [ [ -LRB- cord-333405-ji58jbct 63 31 25 25 CD cord-333405-ji58jbct 63 32 ] ] -RRB- cord-333405-ji58jbct 63 33 [ [ -LRB- cord-333405-ji58jbct 63 34 26 26 CD cord-333405-ji58jbct 63 35 ] ] -RRB- cord-333405-ji58jbct 63 36 [ [ -LRB- cord-333405-ji58jbct 63 37 27 27 CD cord-333405-ji58jbct 63 38 ] ] -RRB- cord-333405-ji58jbct 63 39 [ [ -LRB- cord-333405-ji58jbct 63 40 28 28 CD cord-333405-ji58jbct 63 41 ] ] -RRB- cord-333405-ji58jbct 63 42 [ [ -LRB- cord-333405-ji58jbct 63 43 29 29 CD cord-333405-ji58jbct 63 44 ] ] -RRB- cord-333405-ji58jbct 64 1 [ [ -LRB- cord-333405-ji58jbct 64 2 30 30 CD cord-333405-ji58jbct 64 3 ] ] -RRB- cord-333405-ji58jbct 64 4 [ [ -LRB- cord-333405-ji58jbct 64 5 31 31 CD cord-333405-ji58jbct 64 6 ] ] -RRB- cord-333405-ji58jbct 64 7 . . . cord-333405-ji58jbct 65 1 The the DT cord-333405-ji58jbct 65 2 first first JJ cord-333405-ji58jbct 65 3 epidemic epidemic NN cord-333405-ji58jbct 65 4 of of IN cord-333405-ji58jbct 65 5 HPS hps NN cord-333405-ji58jbct 65 6 , , , cord-333405-ji58jbct 65 7 detected detect VBN cord-333405-ji58jbct 65 8 in in IN cord-333405-ji58jbct 65 9 the the DT cord-333405-ji58jbct 65 10 southwestern southwestern JJ cord-333405-ji58jbct 65 11 region region NN cord-333405-ji58jbct 65 12 of of IN cord-333405-ji58jbct 65 13 the the DT cord-333405-ji58jbct 65 14 United United NNP cord-333405-ji58jbct 65 15 States States NNP cord-333405-ji58jbct 65 16 in in IN cord-333405-ji58jbct 65 17 1993 1993 CD cord-333405-ji58jbct 66 1 ( ( -LRB- cord-333405-ji58jbct 66 2 ref ref NN cord-333405-ji58jbct 66 3 . . . cord-333405-ji58jbct 67 1 38 38 CD cord-333405-ji58jbct 67 2 ) ) -RRB- cord-333405-ji58jbct 67 3 , , , cord-333405-ji58jbct 67 4 resulted result VBD cord-333405-ji58jbct 67 5 from from IN cord-333405-ji58jbct 67 6 population population NN cord-333405-ji58jbct 67 7 booms boom NNS cord-333405-ji58jbct 67 8 of of IN cord-333405-ji58jbct 67 9 the the DT cord-333405-ji58jbct 67 10 deer deer NN cord-333405-ji58jbct 67 11 mouse mouse NN cord-333405-ji58jbct 67 12 Peromyscus Peromyscus NNP cord-333405-ji58jbct 67 13 maniculatis maniculatis NNP cord-333405-ji58jbct 67 14 , , , cord-333405-ji58jbct 67 15 in in IN cord-333405-ji58jbct 67 16 turn turn NN cord-333405-ji58jbct 67 17 caused cause VBN cord-333405-ji58jbct 67 18 by by IN cord-333405-ji58jbct 67 19 climate climate NN cord-333405-ji58jbct 67 20 - - HYPH cord-333405-ji58jbct 67 21 related relate VBN cord-333405-ji58jbct 67 22 and and CC cord-333405-ji58jbct 67 23 recurrent recurrent JJ cord-333405-ji58jbct 67 24 proliferation proliferation NN cord-333405-ji58jbct 67 25 of of IN cord-333405-ji58jbct 67 26 rodent rodent NN cord-333405-ji58jbct 67 27 food food NN cord-333405-ji58jbct 67 28 sources source NNS cord-333405-ji58jbct 67 29 . . . cord-333405-ji58jbct 68 1 Increased increase VBN cord-333405-ji58jbct 68 2 rodent rodent NN cord-333405-ji58jbct 68 3 populations population NNS cord-333405-ji58jbct 68 4 and and CC cord-333405-ji58jbct 68 5 eventual eventual JJ cord-333405-ji58jbct 68 6 shortages shortage NNS cord-333405-ji58jbct 68 7 of of IN cord-333405-ji58jbct 68 8 food food NN cord-333405-ji58jbct 68 9 drove drive VBD cord-333405-ji58jbct 68 10 expanded expand VBN cord-333405-ji58jbct 68 11 deer deer NN cord-333405-ji58jbct 68 12 mouse mouse NN cord-333405-ji58jbct 68 13 populations population NNS cord-333405-ji58jbct 68 14 into into IN cord-333405-ji58jbct 68 15 homes home NNS cord-333405-ji58jbct 68 16 , , , cord-333405-ji58jbct 68 17 exposing expose VBG cord-333405-ji58jbct 68 18 people people NNS cord-333405-ji58jbct 68 19 to to IN cord-333405-ji58jbct 68 20 virus virus NN cord-333405-ji58jbct 68 21 - - HYPH cord-333405-ji58jbct 68 22 containing contain VBG cord-333405-ji58jbct 68 23 droppings dropping NNS cord-333405-ji58jbct 68 24 . . . cord-333405-ji58jbct 69 1 The the DT cord-333405-ji58jbct 69 2 1998 1998 CD cord-333405-ji58jbct 69 3 - - SYM cord-333405-ji58jbct 69 4 1999 1999 CD cord-333405-ji58jbct 69 5 Malaysian Malaysian NNP cord-333405-ji58jbct 69 6 Nipah Nipah NNP cord-333405-ji58jbct 69 7 virus virus NN cord-333405-ji58jbct 69 8 epidemic epidemic NN cord-333405-ji58jbct 69 9 39 39 CD cord-333405-ji58jbct 69 10 further further RB cord-333405-ji58jbct 69 11 illustrates illustrate VBZ cord-333405-ji58jbct 69 12 the the DT cord-333405-ji58jbct 69 13 influence influence NN cord-333405-ji58jbct 69 14 of of IN cord-333405-ji58jbct 69 15 human human JJ cord-333405-ji58jbct 69 16 behaviours behaviour NNS cord-333405-ji58jbct 69 17 and and CC cord-333405-ji58jbct 69 18 environmental environmental JJ cord-333405-ji58jbct 69 19 perturbations perturbation NNS cord-333405-ji58jbct 69 20 on on IN cord-333405-ji58jbct 69 21 newly newly RB cord-333405-ji58jbct 69 22 emerging emerge VBG cord-333405-ji58jbct 69 23 human human JJ cord-333405-ji58jbct 69 24 infections infection NNS cord-333405-ji58jbct 69 25 . . . cord-333405-ji58jbct 70 1 Pigs pig NNS cord-333405-ji58jbct 70 2 crammed cram VBN cord-333405-ji58jbct 70 3 together together RB cord-333405-ji58jbct 70 4 in in IN cord-333405-ji58jbct 70 5 pens pen NNS cord-333405-ji58jbct 70 6 located locate VBN cord-333405-ji58jbct 70 7 in in IN cord-333405-ji58jbct 70 8 or or CC cord-333405-ji58jbct 70 9 near near IN cord-333405-ji58jbct 70 10 orchards orchard NNS cord-333405-ji58jbct 70 11 attracted attract VBD cord-333405-ji58jbct 70 12 fruit fruit NN cord-333405-ji58jbct 70 13 bats bat NNS cord-333405-ji58jbct 70 14 whose whose WP$ cord-333405-ji58jbct 70 15 normal normal JJ cord-333405-ji58jbct 70 16 habitats habitat NNS cord-333405-ji58jbct 70 17 had have VBD cord-333405-ji58jbct 70 18 been be VBN cord-333405-ji58jbct 70 19 destroyed destroy VBN cord-333405-ji58jbct 70 20 by by IN cord-333405-ji58jbct 70 21 deforestation deforestation NN cord-333405-ji58jbct 70 22 and and CC cord-333405-ji58jbct 70 23 whose whose WP$ cord-333405-ji58jbct 70 24 droppings dropping NNS cord-333405-ji58jbct 70 25 contained contain VBD cord-333405-ji58jbct 70 26 the the DT cord-333405-ji58jbct 70 27 then then RB cord-333405-ji58jbct 70 28 - - HYPH cord-333405-ji58jbct 70 29 unknown unknown JJ cord-333405-ji58jbct 70 30 paramyxovirus paramyxovirus NN cord-333405-ji58jbct 70 31 . . . cord-333405-ji58jbct 71 1 Virus virus NN cord-333405-ji58jbct 71 2 aerosolization aerosolization NN cord-333405-ji58jbct 71 3 caused cause VBD cord-333405-ji58jbct 71 4 infection infection NN cord-333405-ji58jbct 71 5 of of IN cord-333405-ji58jbct 71 6 pigs pig NNS cord-333405-ji58jbct 71 7 , , , cord-333405-ji58jbct 71 8 with with IN cord-333405-ji58jbct 71 9 overcrowding overcrowd VBG cord-333405-ji58jbct 71 10 leading lead VBG cord-333405-ji58jbct 71 11 to to IN cord-333405-ji58jbct 71 12 explosive explosive JJ cord-333405-ji58jbct 71 13 transmission transmission NN cord-333405-ji58jbct 71 14 rates rate NNS cord-333405-ji58jbct 71 15 and and CC cord-333405-ji58jbct 71 16 ultimately ultimately RB cord-333405-ji58jbct 71 17 to to IN cord-333405-ji58jbct 71 18 infections infection NNS cord-333405-ji58jbct 71 19 in in IN cord-333405-ji58jbct 71 20 pig pig NN cord-333405-ji58jbct 71 21 handlers handler NNS cord-333405-ji58jbct 71 22 . . . cord-333405-ji58jbct 72 1 Variant Variant NNP cord-333405-ji58jbct 72 2 Creutzfeldt Creutzfeldt NNP cord-333405-ji58jbct 72 3 - - HYPH cord-333405-ji58jbct 72 4 Jakob Jakob NNP cord-333405-ji58jbct 72 5 disease disease NN cord-333405-ji58jbct 72 6 ( ( -LRB- cord-333405-ji58jbct 72 7 vCJD vCJD NNP cord-333405-ji58jbct 72 8 ) ) -RRB- cord-333405-ji58jbct 72 9 is be VBZ cord-333405-ji58jbct 72 10 another another DT cord-333405-ji58jbct 72 11 example example NN cord-333405-ji58jbct 72 12 of of IN cord-333405-ji58jbct 72 13 a a DT cord-333405-ji58jbct 72 14 zoonotic zoonotic JJ cord-333405-ji58jbct 72 15 disease disease NN cord-333405-ji58jbct 72 16 emerging emerge VBG cord-333405-ji58jbct 72 17 in in IN cord-333405-ji58jbct 72 18 humans human NNS cord-333405-ji58jbct 72 19 . . . cord-333405-ji58jbct 73 1 vCJD vCJD NNP cord-333405-ji58jbct 73 2 is be VBZ cord-333405-ji58jbct 73 3 caused cause VBN cord-333405-ji58jbct 73 4 by by IN cord-333405-ji58jbct 73 5 the the DT cord-333405-ji58jbct 73 6 humanadapted humanadapte VBN cord-333405-ji58jbct 73 7 form form NN cord-333405-ji58jbct 73 8 of of IN cord-333405-ji58jbct 73 9 the the DT cord-333405-ji58jbct 73 10 prion prion NN cord-333405-ji58jbct 73 11 associated associate VBN cord-333405-ji58jbct 73 12 with with IN cord-333405-ji58jbct 73 13 the the DT cord-333405-ji58jbct 73 14 emerging emerge VBG cord-333405-ji58jbct 73 15 epizootic epizootic JJ cord-333405-ji58jbct 73 16 ( ( -LRB- cord-333405-ji58jbct 73 17 large large JJ cord-333405-ji58jbct 73 18 - - HYPH cord-333405-ji58jbct 73 19 scale scale NN cord-333405-ji58jbct 73 20 animal animal NN cord-333405-ji58jbct 73 21 outbreak outbreak NN cord-333405-ji58jbct 73 22 ) ) -RRB- cord-333405-ji58jbct 73 23 of of IN cord-333405-ji58jbct 73 24 bovine bovine JJ cord-333405-ji58jbct 73 25 spongiform spongiform JJ cord-333405-ji58jbct 73 26 encephalopathy encephalopathy NN cord-333405-ji58jbct 73 27 ( ( -LRB- cord-333405-ji58jbct 73 28 BSE BSE NNP cord-333405-ji58jbct 73 29 ) ) -RRB- cord-333405-ji58jbct 73 30 40 40 CD cord-333405-ji58jbct 73 31 Figure figure NN cord-333405-ji58jbct 73 32 1 1 CD cord-333405-ji58jbct 73 33 Global global JJ cord-333405-ji58jbct 73 34 examples example NNS cord-333405-ji58jbct 73 35 of of IN cord-333405-ji58jbct 73 36 emerging emerge VBG cord-333405-ji58jbct 73 37 and and CC cord-333405-ji58jbct 73 38 re re JJ cord-333405-ji58jbct 73 39 - - JJ cord-333405-ji58jbct 73 40 emerging emerge VBG cord-333405-ji58jbct 73 41 infectious infectious JJ cord-333405-ji58jbct 73 42 diseases disease NNS cord-333405-ji58jbct 73 43 , , , cord-333405-ji58jbct 73 44 some some DT cord-333405-ji58jbct 73 45 of of IN cord-333405-ji58jbct 73 46 which which WDT cord-333405-ji58jbct 73 47 are be VBP cord-333405-ji58jbct 73 48 discussed discuss VBN cord-333405-ji58jbct 73 49 in in IN cord-333405-ji58jbct 73 50 the the DT cord-333405-ji58jbct 73 51 main main JJ cord-333405-ji58jbct 73 52 text text NN cord-333405-ji58jbct 73 53 . . . cord-333405-ji58jbct 74 1 Red Red NNP cord-333405-ji58jbct 74 2 represents represent VBZ cord-333405-ji58jbct 74 3 newly newly RB cord-333405-ji58jbct 74 4 emerging emerge VBG cord-333405-ji58jbct 74 5 diseases disease NNS cord-333405-ji58jbct 74 6 ; ; : cord-333405-ji58jbct 74 7 blue blue JJ cord-333405-ji58jbct 74 8 , , , cord-333405-ji58jbct 74 9 re re NN cord-333405-ji58jbct 74 10 - - JJ cord-333405-ji58jbct 74 11 emerging emerge VBG cord-333405-ji58jbct 74 12 / / SYM cord-333405-ji58jbct 74 13 resurging resurge VBG cord-333405-ji58jbct 74 14 diseases disease NNS cord-333405-ji58jbct 74 15 ; ; : cord-333405-ji58jbct 74 16 black black JJ cord-333405-ji58jbct 74 17 , , , cord-333405-ji58jbct 74 18 a a DT cord-333405-ji58jbct 74 19 ' ' '' cord-333405-ji58jbct 74 20 deliberately deliberately RB cord-333405-ji58jbct 74 21 emerging emerge VBG cord-333405-ji58jbct 74 22 ' ' '' cord-333405-ji58jbct 74 23 disease disease NN cord-333405-ji58jbct 74 24 . . . cord-333405-ji58jbct 75 1 Adapted adapt VBN cord-333405-ji58jbct 75 2 , , , cord-333405-ji58jbct 75 3 with with IN cord-333405-ji58jbct 75 4 permission permission NN cord-333405-ji58jbct 75 5 , , , cord-333405-ji58jbct 75 6 from from IN cord-333405-ji58jbct 75 7 ref ref NN cord-333405-ji58jbct 75 8 . . . cord-333405-ji58jbct 76 1 23 23 CD cord-333405-ji58jbct 76 2 . . . cord-333405-ji58jbct 77 1 epizootic epizootic NNP cord-333405-ji58jbct 77 2 / / SYM cord-333405-ji58jbct 77 3 vCJD vcjd JJ cord-333405-ji58jbct 77 4 epidemic epidemic NN cord-333405-ji58jbct 77 5 , , , cord-333405-ji58jbct 77 6 primarily primarily RB cord-333405-ji58jbct 77 7 affecting affect VBG cord-333405-ji58jbct 77 8 Great Great NNP cord-333405-ji58jbct 77 9 Britain Britain NNP cord-333405-ji58jbct 77 10 , , , cord-333405-ji58jbct 77 11 probably probably RB cord-333405-ji58jbct 77 12 resulted result VBD cord-333405-ji58jbct 77 13 from from IN cord-333405-ji58jbct 77 14 the the DT cord-333405-ji58jbct 77 15 now now RB cord-333405-ji58jbct 77 16 - - HYPH cord-333405-ji58jbct 77 17 abandoned abandon VBN cord-333405-ji58jbct 77 18 practice practice NN cord-333405-ji58jbct 77 19 of of IN cord-333405-ji58jbct 77 20 supplementing supplement VBG cord-333405-ji58jbct 77 21 cattle cattle NNS cord-333405-ji58jbct 77 22 feed feed VBP cord-333405-ji58jbct 77 23 with with IN cord-333405-ji58jbct 77 24 the the DT cord-333405-ji58jbct 77 25 pulverized pulverize VBN cord-333405-ji58jbct 77 26 meat meat NN cord-333405-ji58jbct 77 27 and and CC cord-333405-ji58jbct 77 28 bones bone NNS cord-333405-ji58jbct 77 29 of of IN cord-333405-ji58jbct 77 30 previously previously RB cord-333405-ji58jbct 77 31 slaughtered slaughter VBN cord-333405-ji58jbct 77 32 cattle cattle NNS cord-333405-ji58jbct 77 33 . . . cord-333405-ji58jbct 78 1 BSE BSE NNP cord-333405-ji58jbct 78 2 itself -PRON- PRP cord-333405-ji58jbct 78 3 is be VBZ cord-333405-ji58jbct 78 4 suspected suspect VBN cord-333405-ji58jbct 78 5 to to TO cord-333405-ji58jbct 78 6 have have VB cord-333405-ji58jbct 78 7 emerged emerge VBN cord-333405-ji58jbct 78 8 because because IN cord-333405-ji58jbct 78 9 of of IN cord-333405-ji58jbct 78 10 even even RB cord-333405-ji58jbct 78 11 earlier early JJR cord-333405-ji58jbct 78 12 use use NN cord-333405-ji58jbct 78 13 of of IN cord-333405-ji58jbct 78 14 cattle cattle NNS cord-333405-ji58jbct 78 15 feed feed NN cord-333405-ji58jbct 78 16 containing contain VBG cord-333405-ji58jbct 78 17 the the DT cord-333405-ji58jbct 78 18 agent agent NN cord-333405-ji58jbct 78 19 of of IN cord-333405-ji58jbct 78 20 sheep sheep NNP cord-333405-ji58jbct 78 21 scrapie scrapie NNP cord-333405-ji58jbct 78 22 , , , cord-333405-ji58jbct 78 23 a a DT cord-333405-ji58jbct 78 24 prion prion NN cord-333405-ji58jbct 78 25 disease disease NN cord-333405-ji58jbct 78 26 recognized recognize VBN cord-333405-ji58jbct 78 27 by by IN cord-333405-ji58jbct 78 28 farmers farmer NNS cord-333405-ji58jbct 78 29 more more JJR cord-333405-ji58jbct 78 30 than than IN cord-333405-ji58jbct 78 31 250 250 CD cord-333405-ji58jbct 78 32 years year NNS cord-333405-ji58jbct 78 33 ago ago RB cord-333405-ji58jbct 78 34 41 41 CD cord-333405-ji58jbct 78 35 . . . cord-333405-ji58jbct 79 1 Alarmingly alarmingly RB cord-333405-ji58jbct 79 2 , , , cord-333405-ji58jbct 79 3 the the DT cord-333405-ji58jbct 79 4 new new JJ cord-333405-ji58jbct 79 5 BSE BSE NNP cord-333405-ji58jbct 79 6 prion prion NN cord-333405-ji58jbct 79 7 has have VBZ cord-333405-ji58jbct 79 8 become become VBN cord-333405-ji58jbct 79 9 uncharacteristically uncharacteristically RB cord-333405-ji58jbct 79 10 promiscuous promiscuous JJ cord-333405-ji58jbct 79 11 : : : cord-333405-ji58jbct 79 12 unlike unlike IN cord-333405-ji58jbct 79 13 most most RBS cord-333405-ji58jbct 79 14 known know VBN cord-333405-ji58jbct 79 15 prions prion NNS cord-333405-ji58jbct 79 16 , , , cord-333405-ji58jbct 79 17 it -PRON- PRP cord-333405-ji58jbct 79 18 readily readily RB cord-333405-ji58jbct 79 19 infects infect VBZ cord-333405-ji58jbct 79 20 multiple multiple JJ cord-333405-ji58jbct 79 21 species specie NNS cord-333405-ji58jbct 79 22 in in IN cord-333405-ji58jbct 79 23 addition addition NN cord-333405-ji58jbct 79 24 to to IN cord-333405-ji58jbct 79 25 humans human NNS cord-333405-ji58jbct 79 26 . . . cord-333405-ji58jbct 80 1 This this DT cord-333405-ji58jbct 80 2 suggests suggest VBZ cord-333405-ji58jbct 80 3 the the DT cord-333405-ji58jbct 80 4 possibility possibility NN cord-333405-ji58jbct 80 5 of of IN cord-333405-ji58jbct 80 6 further further JJ cord-333405-ji58jbct 80 7 emerging emerge VBG cord-333405-ji58jbct 80 8 diseases disease NNS cord-333405-ji58jbct 80 9 associated associate VBN cord-333405-ji58jbct 80 10 with with IN cord-333405-ji58jbct 80 11 prions prion NNS cord-333405-ji58jbct 80 12 with with IN cord-333405-ji58jbct 80 13 currently currently RB cord-333405-ji58jbct 80 14 unknown unknown JJ cord-333405-ji58jbct 80 15 transmissibility transmissibility NN cord-333405-ji58jbct 80 16 to to IN cord-333405-ji58jbct 80 17 humans human NNS cord-333405-ji58jbct 80 18 40 40 CD cord-333405-ji58jbct 80 19 . . . cord-333405-ji58jbct 81 1 The the DT cord-333405-ji58jbct 81 2 recent recent JJ cord-333405-ji58jbct 81 3 reports report NNS cord-333405-ji58jbct 81 4 of of IN cord-333405-ji58jbct 81 5 variant variant JJ cord-333405-ji58jbct 81 6 strains strain NNS cord-333405-ji58jbct 81 7 of of IN cord-333405-ji58jbct 81 8 the the DT cord-333405-ji58jbct 81 9 BSE BSE NNP cord-333405-ji58jbct 81 10 prion prion NN cord-333405-ji58jbct 81 11 42 42 CD cord-333405-ji58jbct 81 12 suggest suggest VBP cord-333405-ji58jbct 81 13 that that IN cord-333405-ji58jbct 81 14 the the DT cord-333405-ji58jbct 81 15 BSE BSE NNP cord-333405-ji58jbct 81 16 agent agent NN cord-333405-ji58jbct 81 17 could could MD cord-333405-ji58jbct 81 18 be be VB cord-333405-ji58jbct 81 19 a a DT cord-333405-ji58jbct 81 20 more more RBR cord-333405-ji58jbct 81 21 serious serious JJ cord-333405-ji58jbct 81 22 threat threat NN cord-333405-ji58jbct 81 23 than than IN cord-333405-ji58jbct 81 24 other other JJ cord-333405-ji58jbct 81 25 animal animal NN cord-333405-ji58jbct 81 26 prions prion NNS cord-333405-ji58jbct 81 27 . . . cord-333405-ji58jbct 82 1 Infectious infectious JJ cord-333405-ji58jbct 82 2 agents agent NNS cord-333405-ji58jbct 82 3 indirectly indirectly RB cord-333405-ji58jbct 82 4 transmitted transmit VBN cord-333405-ji58jbct 82 5 to to IN cord-333405-ji58jbct 82 6 or or CC cord-333405-ji58jbct 82 7 between between IN cord-333405-ji58jbct 82 8 humans human NNS cord-333405-ji58jbct 82 9 by by IN cord-333405-ji58jbct 82 10 way way NN cord-333405-ji58jbct 82 11 of of IN cord-333405-ji58jbct 82 12 human human NN cord-333405-ji58jbct 82 13 - - HYPH cord-333405-ji58jbct 82 14 modified modify VBN cord-333405-ji58jbct 82 15 environments environment NNS cord-333405-ji58jbct 82 16 account account VBP cord-333405-ji58jbct 82 17 for for IN cord-333405-ji58jbct 82 18 other other JJ cord-333405-ji58jbct 82 19 emerging emerge VBG cord-333405-ji58jbct 82 20 zoonoses zoonosis NNS cord-333405-ji58jbct 82 21 , , , cord-333405-ji58jbct 82 22 as as RB cord-333405-ji58jbct 82 23 well well RB cord-333405-ji58jbct 82 24 as as IN cord-333405-ji58jbct 82 25 certain certain JJ cord-333405-ji58jbct 82 26 non non JJ cord-333405-ji58jbct 82 27 - - JJ cord-333405-ji58jbct 82 28 zoonotic zoonotic JJ cord-333405-ji58jbct 82 29 diseases disease NNS cord-333405-ji58jbct 82 30 , , , cord-333405-ji58jbct 82 31 which which WDT cord-333405-ji58jbct 82 32 are be VBP cord-333405-ji58jbct 82 33 discussed discuss VBN cord-333405-ji58jbct 82 34 below below RB cord-333405-ji58jbct 82 35 . . . cord-333405-ji58jbct 83 1 For for IN cord-333405-ji58jbct 83 2 example example NN cord-333405-ji58jbct 83 3 , , , cord-333405-ji58jbct 83 4 legionnaires legionnaire NNS cord-333405-ji58jbct 83 5 ' ' POS cord-333405-ji58jbct 83 6 disease disease NN cord-333405-ji58jbct 83 7 , , , cord-333405-ji58jbct 83 8 first first RB cord-333405-ji58jbct 83 9 identified identify VBN cord-333405-ji58jbct 83 10 in in IN cord-333405-ji58jbct 83 11 1976 1976 CD cord-333405-ji58jbct 83 12 , , , cord-333405-ji58jbct 83 13 is be VBZ cord-333405-ji58jbct 83 14 caused cause VBN cord-333405-ji58jbct 83 15 by by IN cord-333405-ji58jbct 83 16 Legionella Legionella NNP cord-333405-ji58jbct 83 17 pneumophila pneumophila NN cord-333405-ji58jbct 83 18 , , , cord-333405-ji58jbct 83 19 whose whose WP$ cord-333405-ji58jbct 83 20 emergence emergence NN cord-333405-ji58jbct 83 21 as as IN cord-333405-ji58jbct 83 22 a a DT cord-333405-ji58jbct 83 23 human human JJ cord-333405-ji58jbct 83 24 pathogen pathogen NN cord-333405-ji58jbct 83 25 might may MD cord-333405-ji58jbct 83 26 not not RB cord-333405-ji58jbct 83 27 have have VB cord-333405-ji58jbct 83 28 occurred occur VBN cord-333405-ji58jbct 83 29 were be VBD cord-333405-ji58jbct 83 30 it -PRON- PRP cord-333405-ji58jbct 83 31 not not RB cord-333405-ji58jbct 83 32 for for IN cord-333405-ji58jbct 83 33 the the DT cord-333405-ji58jbct 83 34 environmental environmental JJ cord-333405-ji58jbct 83 35 niche niche NN cord-333405-ji58jbct 83 36 provided provide VBN cord-333405-ji58jbct 83 37 by by IN cord-333405-ji58jbct 83 38 air air NN cord-333405-ji58jbct 83 39 - - HYPH cord-333405-ji58jbct 83 40 conditioning conditioning NN cord-333405-ji58jbct 83 41 systems system NNS cord-333405-ji58jbct 83 42 26 26 CD cord-333405-ji58jbct 83 43 . . . cord-333405-ji58jbct 84 1 Campylobacter Campylobacter NNP cord-333405-ji58jbct 84 2 jejuni jejuni NNP cord-333405-ji58jbct 84 3 and and CC cord-333405-ji58jbct 84 4 Shiga Shiga NNP cord-333405-ji58jbct 84 5 - - HYPH cord-333405-ji58jbct 84 6 toxin toxin NN cord-333405-ji58jbct 84 7 - - HYPH cord-333405-ji58jbct 84 8 producing produce VBG cord-333405-ji58jbct 84 9 Escherichia Escherichia NNP cord-333405-ji58jbct 84 10 coli coli NNS cord-333405-ji58jbct 85 1 ( ( -LRB- cord-333405-ji58jbct 85 2 E. E. NNP cord-333405-ji58jbct 85 3 coli coli NNP cord-333405-ji58jbct 85 4 O157 O157 NNP cord-333405-ji58jbct 85 5 : : : cord-333405-ji58jbct 86 1 H7 H7 NNP cord-333405-ji58jbct 86 2 and and CC cord-333405-ji58jbct 86 3 other other JJ cord-333405-ji58jbct 86 4 agents agent NNS cord-333405-ji58jbct 86 5 of of IN cord-333405-ji58jbct 86 6 haemolytic haemolytic JJ cord-333405-ji58jbct 86 7 - - HYPH cord-333405-ji58jbct 86 8 uraemic uraemic JJ cord-333405-ji58jbct 86 9 syndrome syndrome NN cord-333405-ji58jbct 86 10 ) ) -RRB- cord-333405-ji58jbct 86 11 infect infect VB cord-333405-ji58jbct 86 12 agricultural agricultural JJ cord-333405-ji58jbct 86 13 animals animal NNS cord-333405-ji58jbct 86 14 , , , cord-333405-ji58jbct 86 15 gaining gain VBG cord-333405-ji58jbct 86 16 access access NN cord-333405-ji58jbct 86 17 to to IN cord-333405-ji58jbct 86 18 humans human NNS cord-333405-ji58jbct 86 19 through through IN cord-333405-ji58jbct 86 20 food food NN cord-333405-ji58jbct 86 21 , , , cord-333405-ji58jbct 86 22 milk milk NN cord-333405-ji58jbct 86 23 , , , cord-333405-ji58jbct 86 24 water water NN cord-333405-ji58jbct 86 25 or or CC cord-333405-ji58jbct 86 26 direct direct JJ cord-333405-ji58jbct 86 27 animal animal NN cord-333405-ji58jbct 86 28 contact contact NN cord-333405-ji58jbct 86 29 . . . cord-333405-ji58jbct 87 1 Other other JJ cord-333405-ji58jbct 87 2 enteric enteric JJ cord-333405-ji58jbct 87 3 pathogens pathogen NNS cord-333405-ji58jbct 87 4 , , , cord-333405-ji58jbct 87 5 such such JJ cord-333405-ji58jbct 87 6 as as IN cord-333405-ji58jbct 87 7 the the DT cord-333405-ji58jbct 87 8 vibrios vibrio NNS cord-333405-ji58jbct 87 9 causing cause VBG cord-333405-ji58jbct 87 10 classical classical JJ cord-333405-ji58jbct 87 11 cholera cholera NN cord-333405-ji58jbct 87 12 ( ( -LRB- cord-333405-ji58jbct 87 13 re re IN cord-333405-ji58jbct 87 14 - - JJ cord-333405-ji58jbct 87 15 emerging emerging JJ cord-333405-ji58jbct 87 16 ; ; : cord-333405-ji58jbct 87 17 see see VB cord-333405-ji58jbct 87 18 below below RB cord-333405-ji58jbct 87 19 ) ) -RRB- cord-333405-ji58jbct 87 20 and and CC cord-333405-ji58jbct 87 21 serogroup serogroup VB cord-333405-ji58jbct 87 22 O139 o139 JJ cord-333405-ji58jbct 87 23 cholera cholera NN cord-333405-ji58jbct 87 24 , , , cord-333405-ji58jbct 87 25 and and CC cord-333405-ji58jbct 87 26 the the DT cord-333405-ji58jbct 87 27 zoonotic zoonotic JJ cord-333405-ji58jbct 87 28 protozoa protozoan NNS cord-333405-ji58jbct 87 29 Cryptosporidium cryptosporidium NN cord-333405-ji58jbct 87 30 parvum parvum NN cord-333405-ji58jbct 87 31 and and CC cord-333405-ji58jbct 87 32 Cyclospora Cyclospora NNP cord-333405-ji58jbct 87 33 cayetanensis cayetanensis NN cord-333405-ji58jbct 87 34 26 26 CD cord-333405-ji58jbct 87 35 , , , cord-333405-ji58jbct 87 36 seem seem VBP cord-333405-ji58jbct 87 37 to to TO cord-333405-ji58jbct 87 38 have have VB cord-333405-ji58jbct 87 39 come come VBN cord-333405-ji58jbct 87 40 from from IN cord-333405-ji58jbct 87 41 environmental environmental JJ cord-333405-ji58jbct 87 42 or or CC cord-333405-ji58jbct 87 43 animal animal NN cord-333405-ji58jbct 87 44 organisms organism NNS cord-333405-ji58jbct 87 45 that that WDT cord-333405-ji58jbct 87 46 have have VBP cord-333405-ji58jbct 87 47 adapted adapt VBN cord-333405-ji58jbct 87 48 to to IN cord-333405-ji58jbct 87 49 human human NN cord-333405-ji58jbct 87 50 - - HYPH cord-333405-ji58jbct 87 51 to to IN cord-333405-ji58jbct 87 52 - - HYPH cord-333405-ji58jbct 87 53 human human JJ cord-333405-ji58jbct 87 54 ' ' '' cord-333405-ji58jbct 87 55 faecal faecal JJ cord-333405-ji58jbct 87 56 - - HYPH cord-333405-ji58jbct 87 57 oral oral JJ cord-333405-ji58jbct 87 58 ' ' '' cord-333405-ji58jbct 87 59 transmission transmission NN cord-333405-ji58jbct 87 60 through through IN cord-333405-ji58jbct 87 61 water water NN cord-333405-ji58jbct 87 62 . . . cord-333405-ji58jbct 88 1 Some some DT cord-333405-ji58jbct 88 2 EIs ei NNS cord-333405-ji58jbct 88 3 come come VBP cord-333405-ji58jbct 88 4 from from IN cord-333405-ji58jbct 88 5 microorganisms microorganism NNS cord-333405-ji58jbct 88 6 that that WDT cord-333405-ji58jbct 88 7 once once RB cord-333405-ji58jbct 88 8 caused cause VBD cord-333405-ji58jbct 88 9 familiar familiar JJ cord-333405-ji58jbct 88 10 diseases disease NNS cord-333405-ji58jbct 88 11 , , , cord-333405-ji58jbct 88 12 but but CC cord-333405-ji58jbct 88 13 which which WDT cord-333405-ji58jbct 88 14 now now RB cord-333405-ji58jbct 88 15 cause cause VBP cord-333405-ji58jbct 88 16 new new JJ cord-333405-ji58jbct 88 17 or or CC cord-333405-ji58jbct 88 18 previously previously RB cord-333405-ji58jbct 88 19 uncommon uncommon JJ cord-333405-ji58jbct 88 20 diseases disease NNS cord-333405-ji58jbct 88 21 . . . cord-333405-ji58jbct 89 1 Streptococcus streptococcus NN cord-333405-ji58jbct 89 2 pyogenes pyogene NNS cord-333405-ji58jbct 89 3 caused cause VBD cord-333405-ji58jbct 89 4 a a DT cord-333405-ji58jbct 89 5 fatal fatal JJ cord-333405-ji58jbct 89 6 pandemic pandemic NN cord-333405-ji58jbct 89 7 of of IN cord-333405-ji58jbct 89 8 scarlet scarlet JJ cord-333405-ji58jbct 89 9 and and CC cord-333405-ji58jbct 89 10 puerperal puerperal JJ cord-333405-ji58jbct 89 11 fevers fever NNS cord-333405-ji58jbct 89 12 between between IN cord-333405-ji58jbct 89 13 1830 1830 CD cord-333405-ji58jbct 89 14 and and CC cord-333405-ji58jbct 89 15 1900 1900 CD cord-333405-ji58jbct 89 16 ( ( -LRB- cord-333405-ji58jbct 89 17 ref ref NN cord-333405-ji58jbct 89 18 . . . cord-333405-ji58jbct 90 1 44 44 LS cord-333405-ji58jbct 90 2 ) ) -RRB- cord-333405-ji58jbct 90 3 . . . cord-333405-ji58jbct 91 1 Scarlet scarlet JJ cord-333405-ji58jbct 91 2 fever fever NN cord-333405-ji58jbct 91 3 , , , cord-333405-ji58jbct 91 4 then then RB cord-333405-ji58jbct 91 5 the the DT cord-333405-ji58jbct 91 6 leading leading JJ cord-333405-ji58jbct 91 7 cause cause NN cord-333405-ji58jbct 91 8 of of IN cord-333405-ji58jbct 91 9 death death NN cord-333405-ji58jbct 91 10 in in IN cord-333405-ji58jbct 91 11 children child NNS cord-333405-ji58jbct 91 12 , , , cord-333405-ji58jbct 91 13 is be VBZ cord-333405-ji58jbct 91 14 now now RB cord-333405-ji58jbct 91 15 rare rare JJ cord-333405-ji58jbct 91 16 , , , cord-333405-ji58jbct 91 17 but but CC cord-333405-ji58jbct 91 18 has have VBZ cord-333405-ji58jbct 91 19 been be VBN cord-333405-ji58jbct 91 20 largely largely RB cord-333405-ji58jbct 91 21 supplemented supplement VBN cord-333405-ji58jbct 91 22 by by IN cord-333405-ji58jbct 91 23 other other JJ cord-333405-ji58jbct 91 24 streptococcal streptococcal JJ cord-333405-ji58jbct 91 25 complications complication NNS cord-333405-ji58jbct 91 26 such such JJ cord-333405-ji58jbct 91 27 as as IN cord-333405-ji58jbct 91 28 streptococcal streptococcal JJ cord-333405-ji58jbct 91 29 toxic toxic JJ cord-333405-ji58jbct 91 30 shock shock NN cord-333405-ji58jbct 91 31 syndrome syndrome NN cord-333405-ji58jbct 91 32 , , , cord-333405-ji58jbct 91 33 necrotizing necrotize VBG cord-333405-ji58jbct 91 34 fasciitis fasciitis NN cord-333405-ji58jbct 91 35 and and CC cord-333405-ji58jbct 91 36 re re JJ cord-333405-ji58jbct 91 37 - - JJ cord-333405-ji58jbct 91 38 emergent emergent JJ cord-333405-ji58jbct 91 39 rheumatic rheumatic JJ cord-333405-ji58jbct 91 40 fever fever NN cord-333405-ji58jbct 91 41 45 45 CD cord-333405-ji58jbct 91 42 . . . cord-333405-ji58jbct 92 1 When when WRB cord-333405-ji58jbct 92 2 new new JJ cord-333405-ji58jbct 92 3 microbes microbe NNS cord-333405-ji58jbct 92 4 are be VBP cord-333405-ji58jbct 92 5 discovered discover VBN cord-333405-ji58jbct 92 6 , , , cord-333405-ji58jbct 92 7 their -PRON- PRP$ cord-333405-ji58jbct 92 8 emergences emergence NNS cord-333405-ji58jbct 92 9 as as IN cord-333405-ji58jbct 92 10 disease disease NN cord-333405-ji58jbct 92 11 - - HYPH cord-333405-ji58jbct 92 12 causing cause VBG cord-333405-ji58jbct 92 13 pathogens pathogen NNS cord-333405-ji58jbct 92 14 may may MD cord-333405-ji58jbct 92 15 be be VB cord-333405-ji58jbct 92 16 delayed delay VBN cord-333405-ji58jbct 92 17 . . . cord-333405-ji58jbct 93 1 For for IN cord-333405-ji58jbct 93 2 example example NN cord-333405-ji58jbct 93 3 , , , cord-333405-ji58jbct 93 4 in in IN cord-333405-ji58jbct 93 5 1883 1883 CD cord-333405-ji58jbct 93 6 , , , cord-333405-ji58jbct 93 7 Robert Robert NNP cord-333405-ji58jbct 93 8 Koch Koch NNP cord-333405-ji58jbct 93 9 was be VBD cord-333405-ji58jbct 93 10 unable unable JJ cord-333405-ji58jbct 93 11 to to TO cord-333405-ji58jbct 93 12 show show VB cord-333405-ji58jbct 93 13 that that IN cord-333405-ji58jbct 93 14 the the DT cord-333405-ji58jbct 93 15 newly newly RB cord-333405-ji58jbct 93 16 discovered discover VBN cord-333405-ji58jbct 93 17 Koch Koch NNP cord-333405-ji58jbct 93 18 - - HYPH cord-333405-ji58jbct 93 19 Weeks Weeks NNP cord-333405-ji58jbct 93 20 bacillus bacillus NN cord-333405-ji58jbct 93 21 caused cause VBD cord-333405-ji58jbct 93 22 serious serious JJ cord-333405-ji58jbct 93 23 disease disease NN cord-333405-ji58jbct 93 24 . . . cord-333405-ji58jbct 94 1 More More JJR cord-333405-ji58jbct 94 2 than than IN cord-333405-ji58jbct 94 3 a a DT cord-333405-ji58jbct 94 4 century century NN cord-333405-ji58jbct 94 5 later later RB cord-333405-ji58jbct 94 6 , , , cord-333405-ji58jbct 94 7 a a DT cord-333405-ji58jbct 94 8 fatal fatal JJ cord-333405-ji58jbct 94 9 EI EI NNP cord-333405-ji58jbct 94 10 dubbed dub VBN cord-333405-ji58jbct 94 11 Brazilian brazilian JJ cord-333405-ji58jbct 94 12 purpuric purpuric NN cord-333405-ji58jbct 94 13 fever fever NN cord-333405-ji58jbct 94 14 was be VBD cord-333405-ji58jbct 94 15 linked link VBN cord-333405-ji58jbct 94 16 to to IN cord-333405-ji58jbct 94 17 virulent virulent JJ cord-333405-ji58jbct 94 18 clonal clonal JJ cord-333405-ji58jbct 94 19 variants variant NNS cord-333405-ji58jbct 94 20 of of IN cord-333405-ji58jbct 94 21 Haemophilus Haemophilus NNP cord-333405-ji58jbct 94 22 influenzae influenzae NN cord-333405-ji58jbct 94 23 biogroup biogroup NNP cord-333405-ji58jbct 94 24 aegyptius aegyptius NNP cord-333405-ji58jbct 94 25 ( ( -LRB- cord-333405-ji58jbct 94 26 the the DT cord-333405-ji58jbct 94 27 Koch Koch NNP cord-333405-ji58jbct 94 28 - - HYPH cord-333405-ji58jbct 94 29 Weeks Weeks NNP cord-333405-ji58jbct 94 30 bacillus bacillus NN cord-333405-ji58jbct 94 31 ) ) -RRB- cord-333405-ji58jbct 94 32 46 46 CD cord-333405-ji58jbct 94 33 . . . cord-333405-ji58jbct 95 1 Although although IN cord-333405-ji58jbct 95 2 the the DT cord-333405-ji58jbct 95 3 bases basis NNS cord-333405-ji58jbct 95 4 of of IN cord-333405-ji58jbct 95 5 emergences emergence NNS cord-333405-ji58jbct 95 6 of of IN cord-333405-ji58jbct 95 7 new new JJ cord-333405-ji58jbct 95 8 and and CC cord-333405-ji58jbct 95 9 more more RBR cord-333405-ji58jbct 95 10 severe severe JJ cord-333405-ji58jbct 95 11 diseases disease NNS cord-333405-ji58jbct 95 12 caused cause VBN cord-333405-ji58jbct 95 13 by by IN cord-333405-ji58jbct 95 14 S. S. NNP cord-333405-ji58jbct 95 15 pyogenes pyogene NNS cord-333405-ji58jbct 95 16 and and CC cord-333405-ji58jbct 95 17 H. H. NNP cord-333405-ji58jbct 95 18 influenzae influenzae NN cord-333405-ji58jbct 95 19 biogroup biogroup NNP cord-333405-ji58jbct 95 20 aegyptius aegyptius NNP cord-333405-ji58jbct 95 21 are be VBP cord-333405-ji58jbct 95 22 not not RB cord-333405-ji58jbct 95 23 fully fully RB cord-333405-ji58jbct 95 24 known know VBN cord-333405-ji58jbct 95 25 , , , cord-333405-ji58jbct 95 26 in in IN cord-333405-ji58jbct 95 27 both both DT cord-333405-ji58jbct 95 28 cases case NNS cord-333405-ji58jbct 95 29 complex complex JJ cord-333405-ji58jbct 95 30 microbial microbial JJ cord-333405-ji58jbct 95 31 genetic genetic JJ cord-333405-ji58jbct 95 32 events event NNS cord-333405-ji58jbct 95 33 are be VBP cord-333405-ji58jbct 95 34 suspected suspect VBN cord-333405-ji58jbct 95 35 . . . cord-333405-ji58jbct 96 1 The the DT cord-333405-ji58jbct 96 2 distinctive distinctive JJ cord-333405-ji58jbct 96 3 clonal clonal JJ cord-333405-ji58jbct 96 4 variants variant NNS cord-333405-ji58jbct 96 5 associated associate VBN cord-333405-ji58jbct 96 6 with with IN cord-333405-ji58jbct 96 7 severe severe JJ cord-333405-ji58jbct 96 8 H. H. NNP cord-333405-ji58jbct 96 9 influenzae influenzae NN cord-333405-ji58jbct 96 10 biogroup biogroup NNP cord-333405-ji58jbct 96 11 aegyptius aegyptius NNP cord-333405-ji58jbct 96 12 disease disease NNP cord-333405-ji58jbct 96 13 have have VBP cord-333405-ji58jbct 96 14 been be VBN cord-333405-ji58jbct 96 15 shown show VBN cord-333405-ji58jbct 96 16 by by IN cord-333405-ji58jbct 96 17 PCR PCR NNP cord-333405-ji58jbct 96 18 ( ( -LRB- cord-333405-ji58jbct 96 19 polymerase polymerase NN cord-333405-ji58jbct 96 20 chain chain NN cord-333405-ji58jbct 96 21 reaction)-based reaction)-based JJ cord-333405-ji58jbct 96 22 subtractive subtractive JJ cord-333405-ji58jbct 96 23 genome genome NN cord-333405-ji58jbct 96 24 hybridization hybridization NN cord-333405-ji58jbct 96 25 to to TO cord-333405-ji58jbct 96 26 contain contain VB cord-333405-ji58jbct 96 27 not not RB cord-333405-ji58jbct 96 28 only only RB cord-333405-ji58jbct 96 29 a a DT cord-333405-ji58jbct 96 30 unique unique JJ cord-333405-ji58jbct 96 31 plasmid plasmid NN cord-333405-ji58jbct 96 32 , , , cord-333405-ji58jbct 96 33 but but CC cord-333405-ji58jbct 96 34 also also RB cord-333405-ji58jbct 96 35 unique unique JJ cord-333405-ji58jbct 96 36 chromosomal chromosomal JJ cord-333405-ji58jbct 96 37 regions region NNS cord-333405-ji58jbct 96 38 , , , cord-333405-ji58jbct 96 39 some some DT cord-333405-ji58jbct 96 40 of of IN cord-333405-ji58jbct 96 41 which which WDT cord-333405-ji58jbct 96 42 are be VBP cord-333405-ji58jbct 96 43 encoded encode VBN cord-333405-ji58jbct 96 44 by by IN cord-333405-ji58jbct 96 45 bacteriophages bacteriophage NNS cord-333405-ji58jbct 96 46 47 47 CD cord-333405-ji58jbct 96 47 . . . cord-333405-ji58jbct 97 1 This this DT cord-333405-ji58jbct 97 2 research research NN cord-333405-ji58jbct 97 3 has have VBZ cord-333405-ji58jbct 97 4 narrowed narrow VBN cord-333405-ji58jbct 97 5 the the DT cord-333405-ji58jbct 97 6 search search NN cord-333405-ji58jbct 97 7 for for IN cord-333405-ji58jbct 97 8 virulence virulence NN cord-333405-ji58jbct 97 9 determinants determinant NNS cord-333405-ji58jbct 97 10 to to IN cord-333405-ji58jbct 97 11 unique unique JJ cord-333405-ji58jbct 97 12 proteins protein NNS cord-333405-ji58jbct 97 13 , , , cord-333405-ji58jbct 97 14 some some DT cord-333405-ji58jbct 97 15 of of IN cord-333405-ji58jbct 97 16 which which WDT cord-333405-ji58jbct 97 17 may may MD cord-333405-ji58jbct 97 18 have have VB cord-333405-ji58jbct 97 19 been be VBN cord-333405-ji58jbct 97 20 acquired acquire VBN cord-333405-ji58jbct 97 21 from from IN cord-333405-ji58jbct 97 22 other other JJ cord-333405-ji58jbct 97 23 organisms organism NNS cord-333405-ji58jbct 97 24 by by IN cord-333405-ji58jbct 97 25 horizontal horizontal JJ cord-333405-ji58jbct 97 26 gene gene NN cord-333405-ji58jbct 97 27 transfer transfer NN cord-333405-ji58jbct 97 28 . . . cord-333405-ji58jbct 98 1 Streptococcus streptococcus NN cord-333405-ji58jbct 98 2 pyogenes pyogene NNS cord-333405-ji58jbct 98 3 has have VBZ cord-333405-ji58jbct 98 4 been be VBN cord-333405-ji58jbct 98 5 studied study VBN cord-333405-ji58jbct 98 6 more more RBR cord-333405-ji58jbct 98 7 extensively extensively RB cord-333405-ji58jbct 98 8 , , , cord-333405-ji58jbct 98 9 but but CC cord-333405-ji58jbct 98 10 the the DT cord-333405-ji58jbct 98 11 basis basis NN cord-333405-ji58jbct 98 12 of of IN cord-333405-ji58jbct 98 13 severe severe JJ cord-333405-ji58jbct 98 14 disease disease NN cord-333405-ji58jbct 98 15 emergence emergence NN cord-333405-ji58jbct 98 16 seems seem VBZ cord-333405-ji58jbct 98 17 to to TO cord-333405-ji58jbct 98 18 be be VB cord-333405-ji58jbct 98 19 more more RBR cord-333405-ji58jbct 98 20 complex complex JJ cord-333405-ji58jbct 98 21 than than IN cord-333405-ji58jbct 98 22 for for IN cord-333405-ji58jbct 98 23 H. H. NNP cord-333405-ji58jbct 98 24 influenzae influenzae NN cord-333405-ji58jbct 98 25 biogroup biogroup NNP cord-333405-ji58jbct 98 26 aegyptius aegyptius NN cord-333405-ji58jbct 98 27 . . . cord-333405-ji58jbct 99 1 Many many JJ cord-333405-ji58jbct 99 2 factors factor NNS cord-333405-ji58jbct 99 3 associated associate VBN cord-333405-ji58jbct 99 4 with with IN cord-333405-ji58jbct 99 5 streptococcal streptococcal JJ cord-333405-ji58jbct 99 6 virulence virulence NN cord-333405-ji58jbct 99 7 have have VBP cord-333405-ji58jbct 99 8 been be VBN cord-333405-ji58jbct 99 9 identified identify VBN cord-333405-ji58jbct 99 10 in in IN cord-333405-ji58jbct 99 11 strains strain NNS cord-333405-ji58jbct 99 12 bearing bear VBG cord-333405-ji58jbct 99 13 the the DT cord-333405-ji58jbct 99 14 M1 M1 NNP cord-333405-ji58jbct 99 15 surface surface NN cord-333405-ji58jbct 99 16 protein protein NN cord-333405-ji58jbct 99 17 as as RB cord-333405-ji58jbct 99 18 well well RB cord-333405-ji58jbct 99 19 as as IN cord-333405-ji58jbct 99 20 in in IN cord-333405-ji58jbct 99 21 other other JJ cord-333405-ji58jbct 99 22 M M NNP cord-333405-ji58jbct 99 23 protein protein NN cord-333405-ji58jbct 99 24 strains strain NNS cord-333405-ji58jbct 99 25 , , , cord-333405-ji58jbct 99 26 among among IN cord-333405-ji58jbct 99 27 them -PRON- PRP cord-333405-ji58jbct 99 28 bacteriophage bacteriophage NN cord-333405-ji58jbct 99 29 - - HYPH cord-333405-ji58jbct 99 30 encoded encode VBN cord-333405-ji58jbct 99 31 superantigen superantigen NN cord-333405-ji58jbct 99 32 toxins toxin NNS cord-333405-ji58jbct 99 33 and and CC cord-333405-ji58jbct 99 34 a a DT cord-333405-ji58jbct 99 35 protein protein NN cord-333405-ji58jbct 99 36 known know VBN cord-333405-ji58jbct 99 37 as as IN cord-333405-ji58jbct 99 38 sic sic NN cord-333405-ji58jbct 99 39 ( ( -LRB- cord-333405-ji58jbct 99 40 streptococcal streptococcal JJ cord-333405-ji58jbct 99 41 inhibitor inhibitor NN cord-333405-ji58jbct 99 42 of of IN cord-333405-ji58jbct 99 43 complement complement NN cord-333405-ji58jbct 99 44 ) ) -RRB- cord-333405-ji58jbct 99 45 , , , cord-333405-ji58jbct 99 46 which which WDT cord-333405-ji58jbct 99 47 seems seem VBZ cord-333405-ji58jbct 99 48 to to TO cord-333405-ji58jbct 99 49 be be VB cord-333405-ji58jbct 99 50 strongly strongly RB cord-333405-ji58jbct 99 51 selected select VBN cord-333405-ji58jbct 99 52 by by IN cord-333405-ji58jbct 99 53 human human JJ cord-333405-ji58jbct 99 54 host host NN cord-333405-ji58jbct 99 55 mucosal mucosal JJ cord-333405-ji58jbct 99 56 factors factor NNS cord-333405-ji58jbct 99 57 . . . cord-333405-ji58jbct 100 1 Several several JJ cord-333405-ji58jbct 100 2 lines line NNS cord-333405-ji58jbct 100 3 of of IN cord-333405-ji58jbct 100 4 evidence evidence NN cord-333405-ji58jbct 100 5 suggest suggest VBP cord-333405-ji58jbct 100 6 that that IN cord-333405-ji58jbct 100 7 changes change NNS cord-333405-ji58jbct 100 8 in in IN cord-333405-ji58jbct 100 9 streptococcal streptococcal JJ cord-333405-ji58jbct 100 10 virulence virulence NN cord-333405-ji58jbct 100 11 reflect reflect VBP cord-333405-ji58jbct 100 12 genetic genetic JJ cord-333405-ji58jbct 100 13 changes change NNS cord-333405-ji58jbct 100 14 associated associate VBN cord-333405-ji58jbct 100 15 with with IN cord-333405-ji58jbct 100 16 phage phage NN cord-333405-ji58jbct 100 17 integration integration NN cord-333405-ji58jbct 100 18 , , , cord-333405-ji58jbct 100 19 large large JJ cord-333405-ji58jbct 100 20 - - HYPH cord-333405-ji58jbct 100 21 scale scale NN cord-333405-ji58jbct 100 22 chromosomal chromosomal JJ cord-333405-ji58jbct 100 23 rearrangements rearrangement NNS cord-333405-ji58jbct 100 24 and and CC cord-333405-ji58jbct 100 25 possibly possibly RB cord-333405-ji58jbct 100 26 the the DT cord-333405-ji58jbct 100 27 shuffling shuffling NN cord-333405-ji58jbct 100 28 of of IN cord-333405-ji58jbct 100 29 virulence virulence NN cord-333405-ji58jbct 100 30 cassettes cassette NNS cord-333405-ji58jbct 100 31 ( ( -LRB- cord-333405-ji58jbct 100 32 clusters cluster NNS cord-333405-ji58jbct 100 33 of of IN cord-333405-ji58jbct 100 34 genes gene NNS cord-333405-ji58jbct 100 35 responsible responsible JJ cord-333405-ji58jbct 100 36 for for IN cord-333405-ji58jbct 100 37 pathogenicity pathogenicity NN cord-333405-ji58jbct 100 38 ) ) -RRB- cord-333405-ji58jbct 100 39 , , , cord-333405-ji58jbct 100 40 followed follow VBN cord-333405-ji58jbct 100 41 by by IN cord-333405-ji58jbct 100 42 rapid rapid JJ cord-333405-ji58jbct 100 43 human human JJ cord-333405-ji58jbct 100 44 spread spread NN cord-333405-ji58jbct 100 45 and and CC cord-333405-ji58jbct 100 46 immune immune NN cord-333405-ji58jbct 100 47 selection selection NN cord-333405-ji58jbct 100 48 48 48 CD cord-333405-ji58jbct 100 49 , , , cord-333405-ji58jbct 100 50 49 49 CD cord-333405-ji58jbct 100 51 . . . cord-333405-ji58jbct 101 1 Infectious infectious JJ cord-333405-ji58jbct 101 2 agents agent NNS cord-333405-ji58jbct 101 3 that that WDT cord-333405-ji58jbct 101 4 are be VBP cord-333405-ji58jbct 101 5 associated associate VBN cord-333405-ji58jbct 101 6 with with IN cord-333405-ji58jbct 101 7 chronic chronic JJ cord-333405-ji58jbct 101 8 diseases disease NNS cord-333405-ji58jbct 101 9 are be VBP cord-333405-ji58jbct 101 10 one one CD cord-333405-ji58jbct 101 11 of of IN cord-333405-ji58jbct 101 12 the the DT cord-333405-ji58jbct 101 13 most most RBS cord-333405-ji58jbct 101 14 challenging challenging JJ cord-333405-ji58jbct 101 15 categories category NNS cord-333405-ji58jbct 101 16 of of IN cord-333405-ji58jbct 101 17 newly newly RB cord-333405-ji58jbct 101 18 emerging emerge VBG cord-333405-ji58jbct 101 19 ( ( -LRB- cord-333405-ji58jbct 101 20 or or CC cord-333405-ji58jbct 101 21 at at IN cord-333405-ji58jbct 101 22 least least JJS cord-333405-ji58jbct 101 23 newly newly RB cord-333405-ji58jbct 101 24 appreciated appreciate VBN cord-333405-ji58jbct 101 25 ) ) -RRB- cord-333405-ji58jbct 101 26 infections infection NNS cord-333405-ji58jbct 101 27 . . . cord-333405-ji58jbct 102 1 Examples example NNS cord-333405-ji58jbct 102 2 include include VBP cord-333405-ji58jbct 102 3 the the DT cord-333405-ji58jbct 102 4 associations association NNS cord-333405-ji58jbct 102 5 of of IN cord-333405-ji58jbct 102 6 hepatitis hepatitis NNP cord-333405-ji58jbct 102 7 B B NNP cord-333405-ji58jbct 102 8 and and CC cord-333405-ji58jbct 102 9 C C NNP cord-333405-ji58jbct 102 10 with with IN cord-333405-ji58jbct 102 11 chronic chronic JJ cord-333405-ji58jbct 102 12 liver liver NN cord-333405-ji58jbct 102 13 damage damage NN cord-333405-ji58jbct 102 14 and and CC cord-333405-ji58jbct 102 15 hepatocellular hepatocellular JJ cord-333405-ji58jbct 102 16 carcinoma carcinoma NN cord-333405-ji58jbct 102 17 , , , cord-333405-ji58jbct 102 18 of of IN cord-333405-ji58jbct 102 19 certain certain JJ cord-333405-ji58jbct 102 20 genotypes genotype NNS cord-333405-ji58jbct 102 21 of of IN cord-333405-ji58jbct 102 22 human human JJ cord-333405-ji58jbct 102 23 papillomaviruses papillomaviruse NNS cord-333405-ji58jbct 102 24 with with IN cord-333405-ji58jbct 102 25 cancer cancer NN cord-333405-ji58jbct 102 26 of of IN cord-333405-ji58jbct 102 27 the the DT cord-333405-ji58jbct 102 28 uterine uterine JJ cord-333405-ji58jbct 102 29 cervix cervix NN cord-333405-ji58jbct 102 30 , , , cord-333405-ji58jbct 102 31 of of IN cord-333405-ji58jbct 102 32 Epstein Epstein NNP cord-333405-ji58jbct 102 33 - - HYPH cord-333405-ji58jbct 102 34 Barr Barr NNP cord-333405-ji58jbct 102 35 virus virus NN cord-333405-ji58jbct 102 36 with with IN cord-333405-ji58jbct 102 37 Burkitt Burkitt NNP cord-333405-ji58jbct 102 38 's 's POS cord-333405-ji58jbct 102 39 lymphoma lymphoma NN cord-333405-ji58jbct 102 40 ( ( -LRB- cord-333405-ji58jbct 102 41 largely largely RB cord-333405-ji58jbct 102 42 in in IN cord-333405-ji58jbct 102 43 Africa Africa NNP cord-333405-ji58jbct 102 44 ) ) -RRB- cord-333405-ji58jbct 102 45 and and CC cord-333405-ji58jbct 102 46 nasopharyngeal nasopharyngeal JJ cord-333405-ji58jbct 102 47 carcinoma carcinoma NN cord-333405-ji58jbct 102 48 ( ( -LRB- cord-333405-ji58jbct 102 49 in in IN cord-333405-ji58jbct 102 50 China China NNP cord-333405-ji58jbct 102 51 ) ) -RRB- cord-333405-ji58jbct 102 52 , , , cord-333405-ji58jbct 102 53 of of IN cord-333405-ji58jbct 102 54 human human JJ cord-333405-ji58jbct 102 55 herpesvirus herpesvirus NN cord-333405-ji58jbct 102 56 8 8 CD cord-333405-ji58jbct 102 57 with with IN cord-333405-ji58jbct 102 58 Kaposi Kaposi NNP cord-333405-ji58jbct 102 59 sarcoma sarcoma NN cord-333405-ji58jbct 102 60 , , , cord-333405-ji58jbct 102 61 and and CC cord-333405-ji58jbct 102 62 of of IN cord-333405-ji58jbct 102 63 Helicobacter Helicobacter NNP cord-333405-ji58jbct 102 64 pylori pylori NN cord-333405-ji58jbct 102 65 with with IN cord-333405-ji58jbct 102 66 gastric gastric JJ cord-333405-ji58jbct 102 67 ulcers ulcer NNS cord-333405-ji58jbct 102 68 and and CC cord-333405-ji58jbct 102 69 gastric gastric JJ cord-333405-ji58jbct 102 70 cancer cancer NN cord-333405-ji58jbct 102 71 [ [ -LRB- cord-333405-ji58jbct 102 72 50 50 CD cord-333405-ji58jbct 102 73 ] ] -RRB- cord-333405-ji58jbct 102 74 [ [ -LRB- cord-333405-ji58jbct 102 75 51 51 CD cord-333405-ji58jbct 102 76 ] ] -RRB- cord-333405-ji58jbct 102 77 [ [ -LRB- cord-333405-ji58jbct 102 78 52 52 CD cord-333405-ji58jbct 102 79 ] ] -RRB- cord-333405-ji58jbct 102 80 . . . cord-333405-ji58jbct 103 1 Some some DT cord-333405-ji58jbct 103 2 data datum NNS cord-333405-ji58jbct 103 3 even even RB cord-333405-ji58jbct 103 4 suggest suggest VBP cord-333405-ji58jbct 103 5 infectious infectious JJ cord-333405-ji58jbct 103 6 aetiologies aetiology NNS cord-333405-ji58jbct 103 7 for for IN cord-333405-ji58jbct 103 8 cardiovascular cardiovascular JJ cord-333405-ji58jbct 103 9 disease disease NN cord-333405-ji58jbct 103 10 and and CC cord-333405-ji58jbct 103 11 diabetes diabetes NN cord-333405-ji58jbct 103 12 mellitus mellitus NN cord-333405-ji58jbct 103 13 53 53 CD cord-333405-ji58jbct 103 14 , , , cord-333405-ji58jbct 103 15 major major JJ cord-333405-ji58jbct 103 16 causes cause NNS cord-333405-ji58jbct 103 17 of of IN cord-333405-ji58jbct 103 18 death death NN cord-333405-ji58jbct 103 19 and and CC cord-333405-ji58jbct 103 20 disability disability NN cord-333405-ji58jbct 103 21 worldwide worldwide RB cord-333405-ji58jbct 103 22 . . . cord-333405-ji58jbct 104 1 Other other JJ cord-333405-ji58jbct 104 2 associations association NNS cord-333405-ji58jbct 104 3 between between IN cord-333405-ji58jbct 104 4 infectious infectious JJ cord-333405-ji58jbct 104 5 agents agent NNS cord-333405-ji58jbct 104 6 and and CC cord-333405-ji58jbct 104 7 idiopathic idiopathic JJ cord-333405-ji58jbct 104 8 chronic chronic JJ cord-333405-ji58jbct 104 9 diseases disease NNS cord-333405-ji58jbct 104 10 will will MD cord-333405-ji58jbct 104 11 inevitably inevitably RB cord-333405-ji58jbct 104 12 be be VB cord-333405-ji58jbct 104 13 found find VBN cord-333405-ji58jbct 104 14 . . . cord-333405-ji58jbct 104 15 _SP cord-333405-ji58jbct 105 1 Re Re VBG cord-333405-ji58jbct 105 2 - - NN cord-333405-ji58jbct 105 3 emerging emerge VBG cord-333405-ji58jbct 105 4 and and CC cord-333405-ji58jbct 105 5 resurging resurge VBG cord-333405-ji58jbct 105 6 infections infection NNS cord-333405-ji58jbct 105 7 are be VBP cord-333405-ji58jbct 105 8 those those DT cord-333405-ji58jbct 105 9 that that WDT cord-333405-ji58jbct 105 10 existed exist VBD cord-333405-ji58jbct 105 11 in in IN cord-333405-ji58jbct 105 12 the the DT cord-333405-ji58jbct 105 13 past past NN cord-333405-ji58jbct 105 14 but but CC cord-333405-ji58jbct 105 15 are be VBP cord-333405-ji58jbct 105 16 now now RB cord-333405-ji58jbct 105 17 rapidly rapidly RB cord-333405-ji58jbct 105 18 increasing increase VBG cord-333405-ji58jbct 105 19 either either CC cord-333405-ji58jbct 105 20 in in IN cord-333405-ji58jbct 105 21 incidence incidence NN cord-333405-ji58jbct 105 22 or or CC cord-333405-ji58jbct 105 23 in in IN cord-333405-ji58jbct 105 24 geographical geographical JJ cord-333405-ji58jbct 105 25 or or CC cord-333405-ji58jbct 105 26 human human JJ cord-333405-ji58jbct 105 27 host host NN cord-333405-ji58jbct 105 28 range range NN cord-333405-ji58jbct 105 29 . . . cord-333405-ji58jbct 106 1 Re Re NNS cord-333405-ji58jbct 106 2 - - NN cord-333405-ji58jbct 106 3 emergence emergence NN cord-333405-ji58jbct 106 4 is be VBZ cord-333405-ji58jbct 106 5 caused cause VBN cord-333405-ji58jbct 106 6 by by IN cord-333405-ji58jbct 106 7 some some DT cord-333405-ji58jbct 106 8 of of IN cord-333405-ji58jbct 106 9 the the DT cord-333405-ji58jbct 106 10 factors factor NNS cord-333405-ji58jbct 106 11 that that WDT cord-333405-ji58jbct 106 12 cause cause VBP cord-333405-ji58jbct 106 13 newly newly RB cord-333405-ji58jbct 106 14 emerging emerge VBG cord-333405-ji58jbct 106 15 infectious infectious JJ cord-333405-ji58jbct 106 16 diseases disease NNS cord-333405-ji58jbct 106 17 , , , cord-333405-ji58jbct 106 18 such such JJ cord-333405-ji58jbct 106 19 as as IN cord-333405-ji58jbct 106 20 microbial microbial JJ cord-333405-ji58jbct 106 21 evolutionary evolutionary JJ cord-333405-ji58jbct 106 22 vigour vigour NN cord-333405-ji58jbct 106 23 , , , cord-333405-ji58jbct 106 24 zoonotic zoonotic JJ cord-333405-ji58jbct 106 25 encounters encounter NNS cord-333405-ji58jbct 106 26 and and CC cord-333405-ji58jbct 106 27 environmental environmental JJ cord-333405-ji58jbct 106 28 encroachment encroachment NN cord-333405-ji58jbct 106 29 . . . cord-333405-ji58jbct 107 1 Re Re NNS cord-333405-ji58jbct 107 2 - - NNS cord-333405-ji58jbct 107 3 emergences emergence NNS cord-333405-ji58jbct 107 4 or or CC cord-333405-ji58jbct 107 5 at at IN cord-333405-ji58jbct 107 6 least least JJS cord-333405-ji58jbct 107 7 cyclical cyclical JJ cord-333405-ji58jbct 107 8 resurgences resurgence NNS cord-333405-ji58jbct 107 9 of of IN cord-333405-ji58jbct 107 10 some some DT cord-333405-ji58jbct 107 11 diseases disease NNS cord-333405-ji58jbct 107 12 may may MD cord-333405-ji58jbct 107 13 also also RB cord-333405-ji58jbct 107 14 be be VB cord-333405-ji58jbct 107 15 climate climate NN cord-333405-ji58jbct 107 16 - - HYPH cord-333405-ji58jbct 107 17 related relate VBN cord-333405-ji58jbct 107 18 -for -for HYPH cord-333405-ji58jbct 107 19 example example NN cord-333405-ji58jbct 107 20 , , , cord-333405-ji58jbct 107 21 the the DT cord-333405-ji58jbct 107 22 El El NNP cord-333405-ji58jbct 107 23 Niño Niño NNP cord-333405-ji58jbct 107 24 / / SYM cord-333405-ji58jbct 107 25 Southern Southern NNP cord-333405-ji58jbct 107 26 Oscillation Oscillation NNP cord-333405-ji58jbct 107 27 ( ( -LRB- cord-333405-ji58jbct 107 28 ENSO ENSO NNP cord-333405-ji58jbct 107 29 ) ) -RRB- cord-333405-ji58jbct 107 30 phenomenon phenomenon NN cord-333405-ji58jbct 107 31 is be VBZ cord-333405-ji58jbct 107 32 associated associate VBN cord-333405-ji58jbct 107 33 with with IN cord-333405-ji58jbct 107 34 resurgences resurgence NNS cord-333405-ji58jbct 107 35 of of IN cord-333405-ji58jbct 107 36 cholera cholera NN cord-333405-ji58jbct 107 37 and and CC cord-333405-ji58jbct 107 38 malaria malaria NN cord-333405-ji58jbct 107 39 54 54 CD cord-333405-ji58jbct 107 40 . . . cord-333405-ji58jbct 108 1 The the DT cord-333405-ji58jbct 108 2 impact impact NN cord-333405-ji58jbct 108 3 of of IN cord-333405-ji58jbct 108 4 both both CC cord-333405-ji58jbct 108 5 new new JJ cord-333405-ji58jbct 108 6 and and CC cord-333405-ji58jbct 108 7 re re JJ cord-333405-ji58jbct 108 8 - - JJ cord-333405-ji58jbct 108 9 emerging emerge VBG cord-333405-ji58jbct 108 10 infectious infectious JJ cord-333405-ji58jbct 108 11 diseases disease NNS cord-333405-ji58jbct 108 12 on on IN cord-333405-ji58jbct 108 13 human human JJ cord-333405-ji58jbct 108 14 populations population NNS cord-333405-ji58jbct 108 15 is be VBZ cord-333405-ji58jbct 108 16 affected affect VBN cord-333405-ji58jbct 108 17 by by IN cord-333405-ji58jbct 108 18 the the DT cord-333405-ji58jbct 108 19 rate rate NN cord-333405-ji58jbct 108 20 and and CC cord-333405-ji58jbct 108 21 degree degree NN cord-333405-ji58jbct 108 22 to to TO cord-333405-ji58jbct 108 23 which which WDT cord-333405-ji58jbct 108 24 they -PRON- PRP cord-333405-ji58jbct 108 25 spread spread VBD cord-333405-ji58jbct 108 26 across across IN cord-333405-ji58jbct 108 27 geographical geographical JJ cord-333405-ji58jbct 108 28 areas area NNS cord-333405-ji58jbct 108 29 , , , cord-333405-ji58jbct 108 30 depending depend VBG cord-333405-ji58jbct 108 31 on on IN cord-333405-ji58jbct 108 32 the the DT cord-333405-ji58jbct 108 33 movement movement NN cord-333405-ji58jbct 108 34 of of IN cord-333405-ji58jbct 108 35 human human JJ cord-333405-ji58jbct 108 36 hosts host NNS cord-333405-ji58jbct 108 37 or or CC cord-333405-ji58jbct 108 38 of of IN cord-333405-ji58jbct 108 39 the the DT cord-333405-ji58jbct 108 40 vectors vector NNS cord-333405-ji58jbct 108 41 or or CC cord-333405-ji58jbct 108 42 reservoirs reservoir NNS cord-333405-ji58jbct 108 43 of of IN cord-333405-ji58jbct 108 44 infections infection NNS cord-333405-ji58jbct 108 45 . . . cord-333405-ji58jbct 109 1 Travel Travel NNP cord-333405-ji58jbct 109 2 has have VBZ cord-333405-ji58jbct 109 3 an an DT cord-333405-ji58jbct 109 4 important important JJ cord-333405-ji58jbct 109 5 role role NN cord-333405-ji58jbct 109 6 in in IN cord-333405-ji58jbct 109 7 bringing bring VBG cord-333405-ji58jbct 109 8 people people NNS cord-333405-ji58jbct 109 9 into into IN cord-333405-ji58jbct 109 10 contact contact NN cord-333405-ji58jbct 109 11 with with IN cord-333405-ji58jbct 109 12 infectious infectious JJ cord-333405-ji58jbct 109 13 agents agent NNS cord-333405-ji58jbct 109 14 55 55 CD cord-333405-ji58jbct 109 15 . . . cord-333405-ji58jbct 110 1 An an DT cord-333405-ji58jbct 110 2 increase increase NN cord-333405-ji58jbct 110 3 in in IN cord-333405-ji58jbct 110 4 travel travel NN cord-333405-ji58jbct 110 5 - - HYPH cord-333405-ji58jbct 110 6 associated associate VBN cord-333405-ji58jbct 110 7 importations importation NNS cord-333405-ji58jbct 110 8 of of IN cord-333405-ji58jbct 110 9 diseases disease NNS cord-333405-ji58jbct 110 10 was be VBD cord-333405-ji58jbct 110 11 anticipated anticipate VBN cord-333405-ji58jbct 110 12 as as RB cord-333405-ji58jbct 110 13 early early RB cord-333405-ji58jbct 110 14 as as IN cord-333405-ji58jbct 110 15 1933 1933 CD cord-333405-ji58jbct 110 16 , , , cord-333405-ji58jbct 110 17 when when WRB cord-333405-ji58jbct 110 18 commercial commercial JJ cord-333405-ji58jbct 110 19 air air NN cord-333405-ji58jbct 110 20 travel travel NN cord-333405-ji58jbct 110 21 was be VBD cord-333405-ji58jbct 110 22 still still RB cord-333405-ji58jbct 110 23 in in IN cord-333405-ji58jbct 110 24 its -PRON- PRP$ cord-333405-ji58jbct 110 25 infancy infancy NN cord-333405-ji58jbct 110 26 56 56 CD cord-333405-ji58jbct 110 27 . . . cord-333405-ji58jbct 111 1 This this DT cord-333405-ji58jbct 111 2 has have VBZ cord-333405-ji58jbct 111 3 since since IN cord-333405-ji58jbct 111 4 been be VBN cord-333405-ji58jbct 111 5 demonstrated demonstrate VBN cord-333405-ji58jbct 111 6 dramatically dramatically RB cord-333405-ji58jbct 111 7 by by IN cord-333405-ji58jbct 111 8 an an DT cord-333405-ji58jbct 111 9 international international JJ cord-333405-ji58jbct 111 10 airline airline NN cord-333405-ji58jbct 111 11 hub hub NN cord-333405-ji58jbct 111 12 - - HYPH cord-333405-ji58jbct 111 13 to to IN cord-333405-ji58jbct 111 14 - - HYPH cord-333405-ji58jbct 111 15 hub hub NN cord-333405-ji58jbct 111 16 pandemic pandemic NN cord-333405-ji58jbct 111 17 spread spread NN cord-333405-ji58jbct 111 18 of of IN cord-333405-ji58jbct 111 19 acute acute JJ cord-333405-ji58jbct 111 20 haemorrhagic haemorrhagic JJ cord-333405-ji58jbct 111 21 conjunctivitis conjunctivitis NN cord-333405-ji58jbct 111 22 in in IN cord-333405-ji58jbct 111 23 1981 1981 CD cord-333405-ji58jbct 112 1 ( ( -LRB- cord-333405-ji58jbct 112 2 ref ref NN cord-333405-ji58jbct 112 3 . . . cord-333405-ji58jbct 112 4 57 57 CD cord-333405-ji58jbct 112 5 ) ) -RRB- cord-333405-ji58jbct 112 6 , , , cord-333405-ji58jbct 112 7 by by IN cord-333405-ji58jbct 112 8 epidemics epidemic NNS cord-333405-ji58jbct 112 9 of of IN cord-333405-ji58jbct 112 10 meningococcal meningococcal JJ cord-333405-ji58jbct 112 11 meningitis meningitis NN cord-333405-ji58jbct 112 12 associated associate VBN cord-333405-ji58jbct 112 13 with with IN cord-333405-ji58jbct 112 14 the the DT cord-333405-ji58jbct 112 15 Hajj Hajj NNP cord-333405-ji58jbct 112 16 , , , cord-333405-ji58jbct 112 17 and and CC cord-333405-ji58jbct 112 18 more more RBR cord-333405-ji58jbct 112 19 recently recently RB cord-333405-ji58jbct 112 20 by by IN cord-333405-ji58jbct 112 21 the the DT cord-333405-ji58jbct 112 22 exportation exportation NN cord-333405-ji58jbct 112 23 of of IN cord-333405-ji58jbct 112 24 epidemic epidemic NN cord-333405-ji58jbct 112 25 SARS SARS NNP cord-333405-ji58jbct 112 26 ( ( -LRB- cord-333405-ji58jbct 112 27 a a DT cord-333405-ji58jbct 112 28 newly newly RB cord-333405-ji58jbct 112 29 emerging emerge VBG cord-333405-ji58jbct 112 30 disease disease NN cord-333405-ji58jbct 112 31 ) ) -RRB- cord-333405-ji58jbct 112 32 from from IN cord-333405-ji58jbct 112 33 Guangdong Guangdong NNP cord-333405-ji58jbct 112 34 Province Province NNP cord-333405-ji58jbct 112 35 , , , cord-333405-ji58jbct 112 36 China China NNP cord-333405-ji58jbct 112 37 , , , cord-333405-ji58jbct 112 38 to to IN cord-333405-ji58jbct 112 39 Hong Hong NNP cord-333405-ji58jbct 112 40 Kong Kong NNP cord-333405-ji58jbct 112 41 , , , cord-333405-ji58jbct 112 42 and and CC cord-333405-ji58jbct 112 43 from from IN cord-333405-ji58jbct 112 44 there there RB cord-333405-ji58jbct 112 45 to to IN cord-333405-ji58jbct 112 46 Beijing Beijing NNP cord-333405-ji58jbct 112 47 , , , cord-333405-ji58jbct 112 48 Hanoi Hanoi NNP cord-333405-ji58jbct 112 49 , , , cord-333405-ji58jbct 112 50 Singapore Singapore NNP cord-333405-ji58jbct 112 51 , , , cord-333405-ji58jbct 112 52 Toronto Toronto NNP cord-333405-ji58jbct 112 53 and and CC cord-333405-ji58jbct 112 54 elsewhere elsewhere RB cord-333405-ji58jbct 112 55 5 5 CD cord-333405-ji58jbct 113 1 ( ( -LRB- cord-333405-ji58jbct 113 2 Fig Fig NNP cord-333405-ji58jbct 113 3 . . . cord-333405-ji58jbct 113 4 3 3 CD cord-333405-ji58jbct 113 5 ) ) -RRB- cord-333405-ji58jbct 113 6 . . . cord-333405-ji58jbct 114 1 The the DT cord-333405-ji58jbct 114 2 persistent persistent JJ cord-333405-ji58jbct 114 3 spread spread NN cord-333405-ji58jbct 114 4 of of IN cord-333405-ji58jbct 114 5 HIV HIV NNP cord-333405-ji58jbct 114 6 along along IN cord-333405-ji58jbct 114 7 air air NN cord-333405-ji58jbct 114 8 , , , cord-333405-ji58jbct 114 9 trucking trucking NN cord-333405-ji58jbct 114 10 , , , cord-333405-ji58jbct 114 11 drug drug NN cord-333405-ji58jbct 114 12 - - HYPH cord-333405-ji58jbct 114 13 trafficking trafficking NN cord-333405-ji58jbct 114 14 and and CC cord-333405-ji58jbct 114 15 troop troop NN cord-333405-ji58jbct 114 16 - - HYPH cord-333405-ji58jbct 114 17 deployment deployment NN cord-333405-ji58jbct 114 18 routes route NNS cord-333405-ji58jbct 114 19 is be VBZ cord-333405-ji58jbct 114 20 a a DT cord-333405-ji58jbct 114 21 deadly deadly JJ cord-333405-ji58jbct 114 22 variation variation NN cord-333405-ji58jbct 114 23 on on IN cord-333405-ji58jbct 114 24 this this DT cord-333405-ji58jbct 114 25 theme theme NN cord-333405-ji58jbct 114 26 [ [ -LRB- cord-333405-ji58jbct 114 27 35 35 CD cord-333405-ji58jbct 114 28 ] ] -RRB- cord-333405-ji58jbct 114 29 [ [ -LRB- cord-333405-ji58jbct 114 30 36 36 CD cord-333405-ji58jbct 114 31 ] ] -RRB- cord-333405-ji58jbct 114 32 [ [ -LRB- cord-333405-ji58jbct 114 33 37 37 CD cord-333405-ji58jbct 114 34 ] ] -RRB- cord-333405-ji58jbct 114 35 . . . cord-333405-ji58jbct 115 1 Plasmodium plasmodium NN cord-333405-ji58jbct 115 2 falciparum falciparum NN cord-333405-ji58jbct 115 3 malaria malaria NN cord-333405-ji58jbct 115 4 was be VBD cord-333405-ji58jbct 115 5 neglected neglect VBN cord-333405-ji58jbct 115 6 for for IN cord-333405-ji58jbct 115 7 several several JJ cord-333405-ji58jbct 115 8 decades decade NNS cord-333405-ji58jbct 115 9 , , , cord-333405-ji58jbct 115 10 but but CC cord-333405-ji58jbct 115 11 is be VBZ cord-333405-ji58jbct 115 12 now now RB cord-333405-ji58jbct 115 13 among among IN cord-333405-ji58jbct 115 14 the the DT cord-333405-ji58jbct 115 15 most most RBS cord-333405-ji58jbct 115 16 important important JJ cord-333405-ji58jbct 115 17 re re NN cord-333405-ji58jbct 115 18 - - JJ cord-333405-ji58jbct 115 19 emerging emerge VBG cord-333405-ji58jbct 115 20 diseases disease NNS cord-333405-ji58jbct 115 21 worldwide worldwide RB cord-333405-ji58jbct 115 22 ( ( -LRB- cord-333405-ji58jbct 115 23 Fig fig NN cord-333405-ji58jbct 115 24 . . NNP cord-333405-ji58jbct 115 25 2 2 CD cord-333405-ji58jbct 115 26 ) ) -RRB- cord-333405-ji58jbct 115 27 . . . cord-333405-ji58jbct 116 1 Years year NNS cord-333405-ji58jbct 116 2 of of IN cord-333405-ji58jbct 116 3 effective effective JJ cord-333405-ji58jbct 116 4 use use NN cord-333405-ji58jbct 116 5 of of IN cord-333405-ji58jbct 116 6 dichlorodiphenyltrichloroethane dichlorodiphenyltrichloroethane NN cord-333405-ji58jbct 116 7 ( ( -LRB- cord-333405-ji58jbct 116 8 DDT DDT NNP cord-333405-ji58jbct 116 9 ) ) -RRB- cord-333405-ji58jbct 116 10 led lead VBD cord-333405-ji58jbct 116 11 to to IN cord-333405-ji58jbct 116 12 the the DT cord-333405-ji58jbct 116 13 abandonment abandonment NN cord-333405-ji58jbct 116 14 of of IN cord-333405-ji58jbct 116 15 other other JJ cord-333405-ji58jbct 116 16 mosquito mosquito NN cord-333405-ji58jbct 116 17 - - HYPH cord-333405-ji58jbct 116 18 control control NN cord-333405-ji58jbct 116 19 programmes programme NNS cord-333405-ji58jbct 116 20 , , , cord-333405-ji58jbct 116 21 but but CC cord-333405-ji58jbct 116 22 the the DT cord-333405-ji58jbct 116 23 insecticide insecticide NN cord-333405-ji58jbct 116 24 fell fall VBD cord-333405-ji58jbct 116 25 into into IN cord-333405-ji58jbct 116 26 disuse disuse NN cord-333405-ji58jbct 116 27 because because IN cord-333405-ji58jbct 116 28 of of IN cord-333405-ji58jbct 116 29 mosquito mosquito NN cord-333405-ji58jbct 116 30 resistance resistance NN cord-333405-ji58jbct 116 31 and and CC cord-333405-ji58jbct 116 32 concerns concern NNS cord-333405-ji58jbct 116 33 about about IN cord-333405-ji58jbct 116 34 the the DT cord-333405-ji58jbct 116 35 insecticide insecticide NN cord-333405-ji58jbct 116 36 's 's POS cord-333405-ji58jbct 116 37 potentially potentially RB cord-333405-ji58jbct 116 38 harmful harmful JJ cord-333405-ji58jbct 116 39 effects effect NNS cord-333405-ji58jbct 116 40 on on IN cord-333405-ji58jbct 116 41 humans human NNS cord-333405-ji58jbct 116 42 and and CC cord-333405-ji58jbct 116 43 wildlife wildlife NN cord-333405-ji58jbct 116 44 . . . cord-333405-ji58jbct 117 1 Consequently consequently RB cord-333405-ji58jbct 117 2 , , , cord-333405-ji58jbct 117 3 malaria malaria NN cord-333405-ji58jbct 117 4 has have VBZ cord-333405-ji58jbct 117 5 re re VBN cord-333405-ji58jbct 117 6 - - VBN cord-333405-ji58jbct 117 7 emerged emerge VBN cord-333405-ji58jbct 117 8 , , , cord-333405-ji58jbct 117 9 and and CC cord-333405-ji58jbct 117 10 the the DT cord-333405-ji58jbct 117 11 situation situation NN cord-333405-ji58jbct 117 12 has have VBZ cord-333405-ji58jbct 117 13 been be VBN cord-333405-ji58jbct 117 14 worsened worsen VBN cord-333405-ji58jbct 117 15 by by IN cord-333405-ji58jbct 117 16 the the DT cord-333405-ji58jbct 117 17 development development NN cord-333405-ji58jbct 117 18 of of IN cord-333405-ji58jbct 117 19 drug drug NN cord-333405-ji58jbct 117 20 resistance resistance NN cord-333405-ji58jbct 117 21 to to IN cord-333405-ji58jbct 117 22 chloroquine chloroquine NN cord-333405-ji58jbct 117 23 and and CC cord-333405-ji58jbct 117 24 mefloquine mefloquine NNP cord-333405-ji58jbct 117 25 58 58 CD cord-333405-ji58jbct 117 26 . . . cord-333405-ji58jbct 118 1 Research research NN cord-333405-ji58jbct 118 2 efforts effort NNS cord-333405-ji58jbct 118 3 focus focus VBP cord-333405-ji58jbct 118 4 on on IN cord-333405-ji58jbct 118 5 the the DT cord-333405-ji58jbct 118 6 development development NN cord-333405-ji58jbct 118 7 of of IN cord-333405-ji58jbct 118 8 vaccines vaccine NNS cord-333405-ji58jbct 118 9 59 59 CD cord-333405-ji58jbct 118 10 and and CC cord-333405-ji58jbct 118 11 new new JJ cord-333405-ji58jbct 118 12 drugs drug NNS cord-333405-ji58jbct 118 13 , , , cord-333405-ji58jbct 118 14 and and CC cord-333405-ji58jbct 118 15 on on IN cord-333405-ji58jbct 118 16 re re VBG cord-333405-ji58jbct 118 17 - - JJ cord-333405-ji58jbct 118 18 establishing establish VBG cord-333405-ji58jbct 118 19 public public JJ cord-333405-ji58jbct 118 20 health health NN cord-333405-ji58jbct 118 21 measures measure NNS cord-333405-ji58jbct 118 22 such such JJ cord-333405-ji58jbct 118 23 as as IN cord-333405-ji58jbct 118 24 the the DT cord-333405-ji58jbct 118 25 use use NN cord-333405-ji58jbct 118 26 of of IN cord-333405-ji58jbct 118 27 bed bed NN cord-333405-ji58jbct 118 28 nets net NNS cord-333405-ji58jbct 118 29 . . . cord-333405-ji58jbct 119 1 Tuberculosis tuberculosis NN cord-333405-ji58jbct 119 2 is be VBZ cord-333405-ji58jbct 119 3 one one CD cord-333405-ji58jbct 119 4 of of IN cord-333405-ji58jbct 119 5 the the DT cord-333405-ji58jbct 119 6 most most RBS cord-333405-ji58jbct 119 7 deadly deadly JJ cord-333405-ji58jbct 119 8 re re NN cord-333405-ji58jbct 119 9 - - JJ cord-333405-ji58jbct 119 10 emerging emerge VBG cord-333405-ji58jbct 119 11 diseases disease NNS cord-333405-ji58jbct 119 12 ( ( -LRB- cord-333405-ji58jbct 119 13 Fig fig NN cord-333405-ji58jbct 119 14 . . NNP cord-333405-ji58jbct 119 15 2 2 CD cord-333405-ji58jbct 119 16 ) ) -RRB- cord-333405-ji58jbct 119 17 . . . cord-333405-ji58jbct 120 1 The the DT cord-333405-ji58jbct 120 2 discovery discovery NN cord-333405-ji58jbct 120 3 of of IN cord-333405-ji58jbct 120 4 isoniazid isoniazid NN cord-333405-ji58jbct 120 5 and and CC cord-333405-ji58jbct 120 6 other other JJ cord-333405-ji58jbct 120 7 drugs drug NNS cord-333405-ji58jbct 120 8 initially initially RB cord-333405-ji58jbct 120 9 led lead VBD cord-333405-ji58jbct 120 10 to to IN cord-333405-ji58jbct 120 11 effective effective JJ cord-333405-ji58jbct 120 12 tuberculosis tuberculosis NN cord-333405-ji58jbct 120 13 cures cure NNS cord-333405-ji58jbct 120 14 , , , cord-333405-ji58jbct 120 15 empty empty JJ cord-333405-ji58jbct 120 16 sanitoria sanitoria NN cord-333405-ji58jbct 120 17 and and CC cord-333405-ji58jbct 120 18 the the DT cord-333405-ji58jbct 120 19 dismantling dismantling NN cord-333405-ji58jbct 120 20 of of IN cord-333405-ji58jbct 120 21 public public JJ cord-333405-ji58jbct 120 22 health health NN cord-333405-ji58jbct 120 23 control control NN cord-333405-ji58jbct 120 24 systems system NNS cord-333405-ji58jbct 120 25 in in IN cord-333405-ji58jbct 120 26 developed develop VBN cord-333405-ji58jbct 120 27 nations nation NNS cord-333405-ji58jbct 120 28 . . . cord-333405-ji58jbct 121 1 Consequently consequently RB cord-333405-ji58jbct 121 2 , , , cord-333405-ji58jbct 121 3 by by IN cord-333405-ji58jbct 121 4 the the DT cord-333405-ji58jbct 121 5 1980s 1980 NNS cord-333405-ji58jbct 121 6 , , , cord-333405-ji58jbct 121 7 when when WRB cord-333405-ji58jbct 121 8 tuberculosis tuberculosis NN cord-333405-ji58jbct 121 9 had have VBD cord-333405-ji58jbct 121 10 re re VBN cord-333405-ji58jbct 121 11 - - VBN cord-333405-ji58jbct 121 12 emerged emerge VBN cord-333405-ji58jbct 121 13 in in IN cord-333405-ji58jbct 121 14 the the DT cord-333405-ji58jbct 121 15 era era NN cord-333405-ji58jbct 121 16 of of IN cord-333405-ji58jbct 121 17 HIV HIV NNP cord-333405-ji58jbct 121 18 / / SYM cord-333405-ji58jbct 121 19 AIDS AIDS NNP cord-333405-ji58jbct 121 20 , , , cord-333405-ji58jbct 121 21 local local JJ cord-333405-ji58jbct 121 22 and and CC cord-333405-ji58jbct 121 23 state state NN cord-333405-ji58jbct 121 24 health health NN cord-333405-ji58jbct 121 25 departments department NNS cord-333405-ji58jbct 121 26 in in IN cord-333405-ji58jbct 121 27 the the DT cord-333405-ji58jbct 121 28 United United NNP cord-333405-ji58jbct 121 29 States States NNP cord-333405-ji58jbct 121 30 lacked lack VBD cord-333405-ji58jbct 121 31 field field NN cord-333405-ji58jbct 121 32 , , , cord-333405-ji58jbct 121 33 laboratory laboratory NN cord-333405-ji58jbct 121 34 and and CC cord-333405-ji58jbct 121 35 clinical clinical JJ cord-333405-ji58jbct 121 36 staff staff NN cord-333405-ji58jbct 121 37 and and CC cord-333405-ji58jbct 121 38 so so RB cord-333405-ji58jbct 121 39 had have VBD cord-333405-ji58jbct 121 40 to to TO cord-333405-ji58jbct 121 41 reinvent reinvent VB cord-333405-ji58jbct 121 42 tuberculosiscontrol tuberculosiscontrol NNP cord-333405-ji58jbct 121 43 programmes programme NNS cord-333405-ji58jbct 121 44 25 25 CD cord-333405-ji58jbct 121 45 . . . cord-333405-ji58jbct 122 1 The the DT cord-333405-ji58jbct 122 2 remarkable remarkable JJ cord-333405-ji58jbct 122 3 re re NN cord-333405-ji58jbct 122 4 - - NN cord-333405-ji58jbct 122 5 emergence emergence NN cord-333405-ji58jbct 122 6 of of IN cord-333405-ji58jbct 122 7 tuberculosis tuberculosis NN cord-333405-ji58jbct 122 8 was be VBD cord-333405-ji58jbct 122 9 fuelled fuel VBN cord-333405-ji58jbct 122 10 by by IN cord-333405-ji58jbct 122 11 the the DT cord-333405-ji58jbct 122 12 immune immune JJ cord-333405-ji58jbct 122 13 deficiencies deficiency NNS cord-333405-ji58jbct 122 14 of of IN cord-333405-ji58jbct 122 15 people people NNS cord-333405-ji58jbct 122 16 with with IN cord-333405-ji58jbct 122 17 AIDS AIDS NNP cord-333405-ji58jbct 122 18 , , , cord-333405-ji58jbct 122 19 which which WDT cord-333405-ji58jbct 122 20 greatly greatly RB cord-333405-ji58jbct 122 21 increases increase VBZ cord-333405-ji58jbct 122 22 the the DT cord-333405-ji58jbct 122 23 risk risk NN cord-333405-ji58jbct 122 24 of of IN cord-333405-ji58jbct 122 25 latent latent JJ cord-333405-ji58jbct 122 26 Mycobacterium Mycobacterium NNP cord-333405-ji58jbct 122 27 tuberculosis tuberculosis NN cord-333405-ji58jbct 122 28 infections infection NNS cord-333405-ji58jbct 122 29 progressing progress VBG cord-333405-ji58jbct 122 30 to to IN cord-333405-ji58jbct 122 31 active active JJ cord-333405-ji58jbct 122 32 disease disease NN cord-333405-ji58jbct 122 33 , , , cord-333405-ji58jbct 122 34 and and CC cord-333405-ji58jbct 122 35 being be VBG cord-333405-ji58jbct 122 36 transmitted transmit VBN cord-333405-ji58jbct 122 37 to to IN cord-333405-ji58jbct 122 38 others other NNS cord-333405-ji58jbct 122 39 . . . cord-333405-ji58jbct 123 1 Inadequate inadequate JJ cord-333405-ji58jbct 123 2 courses course NNS cord-333405-ji58jbct 123 3 of of IN cord-333405-ji58jbct 123 4 anti anti JJ cord-333405-ji58jbct 123 5 - - JJ cord-333405-ji58jbct 123 6 tuberculosis tuberculosis JJ cord-333405-ji58jbct 123 7 therapy therapy NN cord-333405-ji58jbct 123 8 compound compound VB cord-333405-ji58jbct 123 9 the the DT cord-333405-ji58jbct 123 10 problem problem NN cord-333405-ji58jbct 123 11 , , , cord-333405-ji58jbct 123 12 leading lead VBG cord-333405-ji58jbct 123 13 to to IN cord-333405-ji58jbct 123 14 the the DT cord-333405-ji58jbct 123 15 emergence emergence NN cord-333405-ji58jbct 123 16 and and CC cord-333405-ji58jbct 123 17 spread spread NN cord-333405-ji58jbct 123 18 of of IN cord-333405-ji58jbct 123 19 drug drug NN cord-333405-ji58jbct 123 20 - - HYPH cord-333405-ji58jbct 123 21 resistant resistant JJ cord-333405-ji58jbct 123 22 and and CC cord-333405-ji58jbct 123 23 multidrug multidrug NN cord-333405-ji58jbct 123 24 - - HYPH cord-333405-ji58jbct 123 25 resistant resistant JJ cord-333405-ji58jbct 123 26 strains strain NNS cord-333405-ji58jbct 123 27 60 60 CD cord-333405-ji58jbct 123 28 , , , cord-333405-ji58jbct 123 29 and and CC cord-333405-ji58jbct 123 30 a a DT cord-333405-ji58jbct 123 31 need need NN cord-333405-ji58jbct 123 32 for for IN cord-333405-ji58jbct 123 33 more more RBR cord-333405-ji58jbct 123 34 expensive expensive JJ cord-333405-ji58jbct 123 35 treatment treatment NN cord-333405-ji58jbct 123 36 strategies strategy NNS cord-333405-ji58jbct 123 37 such such JJ cord-333405-ji58jbct 123 38 as as IN cord-333405-ji58jbct 123 39 directly directly RB cord-333405-ji58jbct 123 40 observed observe VBN cord-333405-ji58jbct 123 41 therapy therapy NN cord-333405-ji58jbct 123 42 . . . cord-333405-ji58jbct 124 1 It -PRON- PRP cord-333405-ji58jbct 124 2 has have VBZ cord-333405-ji58jbct 124 3 been be VBN cord-333405-ji58jbct 124 4 known know VBN cord-333405-ji58jbct 124 5 for for IN cord-333405-ji58jbct 124 6 over over IN cord-333405-ji58jbct 124 7 a a DT cord-333405-ji58jbct 124 8 century century NN cord-333405-ji58jbct 124 9 that that WDT cord-333405-ji58jbct 124 10 tuberculosis tuberculosis NN cord-333405-ji58jbct 124 11 is be VBZ cord-333405-ji58jbct 124 12 a a DT cord-333405-ji58jbct 124 13 disease disease NN cord-333405-ji58jbct 124 14 of of IN cord-333405-ji58jbct 124 15 poverty poverty NN cord-333405-ji58jbct 124 16 , , , cord-333405-ji58jbct 124 17 associated associate VBN cord-333405-ji58jbct 124 18 with with IN cord-333405-ji58jbct 124 19 crowding crowd VBG cord-333405-ji58jbct 124 20 and and CC cord-333405-ji58jbct 124 21 inadequate inadequate JJ cord-333405-ji58jbct 124 22 hygiene hygiene NN cord-333405-ji58jbct 124 23 . . . cord-333405-ji58jbct 125 1 The the DT cord-333405-ji58jbct 125 2 continuing continue VBG cord-333405-ji58jbct 125 3 expansion expansion NN cord-333405-ji58jbct 125 4 of of IN cord-333405-ji58jbct 125 5 global global JJ cord-333405-ji58jbct 125 6 populations population NNS cord-333405-ji58jbct 125 7 living live VBG cord-333405-ji58jbct 125 8 in in IN cord-333405-ji58jbct 125 9 poverty poverty NN cord-333405-ji58jbct 125 10 makes make VBZ cord-333405-ji58jbct 125 11 tuberculosis tuberculosis NN cord-333405-ji58jbct 125 12 more more RBR cord-333405-ji58jbct 125 13 difficult difficult JJ cord-333405-ji58jbct 125 14 to to TO cord-333405-ji58jbct 125 15 control control VB cord-333405-ji58jbct 125 16 . . . cord-333405-ji58jbct 126 1 63 63 CD cord-333405-ji58jbct 126 2 . . . cord-333405-ji58jbct 127 1 Immune immune JJ cord-333405-ji58jbct 127 2 deficiency deficiency NN cord-333405-ji58jbct 127 3 associated associate VBN cord-333405-ji58jbct 127 4 with with IN cord-333405-ji58jbct 127 5 AIDS AIDS NNP cord-333405-ji58jbct 127 6 , , , cord-333405-ji58jbct 127 7 and and CC cord-333405-ji58jbct 127 8 with with IN cord-333405-ji58jbct 127 9 chemotherapy chemotherapy NN cord-333405-ji58jbct 127 10 for for IN cord-333405-ji58jbct 127 11 cancer cancer NN cord-333405-ji58jbct 127 12 , , , cord-333405-ji58jbct 127 13 immune immune NN cord-333405-ji58jbct 127 14 - - HYPH cord-333405-ji58jbct 127 15 mediated mediate VBN cord-333405-ji58jbct 127 16 diseases disease NNS cord-333405-ji58jbct 127 17 and and CC cord-333405-ji58jbct 127 18 transplantation transplantation NN cord-333405-ji58jbct 127 19 , , , cord-333405-ji58jbct 127 20 has have VBZ cord-333405-ji58jbct 127 21 contributed contribute VBN cord-333405-ji58jbct 127 22 to to IN cord-333405-ji58jbct 127 23 an an DT cord-333405-ji58jbct 127 24 enormous enormous JJ cord-333405-ji58jbct 127 25 global global JJ cord-333405-ji58jbct 127 26 increase increase NN cord-333405-ji58jbct 127 27 in in IN cord-333405-ji58jbct 127 28 the the DT cord-333405-ji58jbct 127 29 numbers number NNS cord-333405-ji58jbct 127 30 of of IN cord-333405-ji58jbct 127 31 immunosuppressed immunosuppressed JJ cord-333405-ji58jbct 127 32 people people NNS cord-333405-ji58jbct 127 33 over over IN cord-333405-ji58jbct 127 34 the the DT cord-333405-ji58jbct 127 35 past past JJ cord-333405-ji58jbct 127 36 few few JJ cord-333405-ji58jbct 127 37 decades decade NNS cord-333405-ji58jbct 127 38 ( ( -LRB- cord-333405-ji58jbct 127 39 probably probably RB cord-333405-ji58jbct 127 40 more more JJR cord-333405-ji58jbct 127 41 than than IN cord-333405-ji58jbct 127 42 1 1 CD cord-333405-ji58jbct 127 43 % % NN cord-333405-ji58jbct 127 44 of of IN cord-333405-ji58jbct 127 45 the the DT cord-333405-ji58jbct 127 46 world world NN cord-333405-ji58jbct 127 47 's 's POS cord-333405-ji58jbct 127 48 population population NN cord-333405-ji58jbct 127 49 ) ) -RRB- cord-333405-ji58jbct 127 50 , , , cord-333405-ji58jbct 127 51 setting set VBG cord-333405-ji58jbct 127 52 the the DT cord-333405-ji58jbct 127 53 stage stage NN cord-333405-ji58jbct 127 54 for for IN cord-333405-ji58jbct 127 55 the the DT cord-333405-ji58jbct 127 56 re re NN cord-333405-ji58jbct 127 57 - - NN cord-333405-ji58jbct 127 58 emergence emergence NN cord-333405-ji58jbct 127 59 of of IN cord-333405-ji58jbct 127 60 many many JJ cord-333405-ji58jbct 127 61 opportunistic opportunistic JJ cord-333405-ji58jbct 127 62 infections infection NNS cord-333405-ji58jbct 127 63 . . . cord-333405-ji58jbct 128 1 HIV HIV NNP cord-333405-ji58jbct 128 2 , , , cord-333405-ji58jbct 128 3 which which WDT cord-333405-ji58jbct 128 4 has have VBZ cord-333405-ji58jbct 128 5 infected infect VBN cord-333405-ji58jbct 128 6 more more JJR cord-333405-ji58jbct 128 7 than than IN cord-333405-ji58jbct 128 8 60 60 CD cord-333405-ji58jbct 128 9 million million CD cord-333405-ji58jbct 128 10 people people NNS cord-333405-ji58jbct 128 11 globally globally RB cord-333405-ji58jbct 128 12 33 33 CD cord-333405-ji58jbct 128 13 , , , cord-333405-ji58jbct 128 14 is be VBZ cord-333405-ji58jbct 128 15 the the DT cord-333405-ji58jbct 128 16 largest large JJS cord-333405-ji58jbct 128 17 single single JJ cord-333405-ji58jbct 128 18 cause cause NN cord-333405-ji58jbct 128 19 of of IN cord-333405-ji58jbct 128 20 human human JJ cord-333405-ji58jbct 128 21 immune immune JJ cord-333405-ji58jbct 128 22 deficiency deficiency NN cord-333405-ji58jbct 128 23 and and CC cord-333405-ji58jbct 128 24 markedly markedly RB cord-333405-ji58jbct 128 25 increases increase VBZ cord-333405-ji58jbct 128 26 vulnerability vulnerability NN cord-333405-ji58jbct 128 27 to to IN cord-333405-ji58jbct 128 28 a a DT cord-333405-ji58jbct 128 29 wide wide JJ cord-333405-ji58jbct 128 30 range range NN cord-333405-ji58jbct 128 31 of of IN cord-333405-ji58jbct 128 32 opportunistic opportunistic JJ cord-333405-ji58jbct 128 33 pathogens pathogen NNS cord-333405-ji58jbct 128 34 , , , cord-333405-ji58jbct 128 35 including include VBG cord-333405-ji58jbct 128 36 Pneumocystis Pneumocystis NNP cord-333405-ji58jbct 128 37 carinii carinii NN cord-333405-ji58jbct 128 38 , , , cord-333405-ji58jbct 128 39 various various JJ cord-333405-ji58jbct 128 40 fungi fungus NNS cord-333405-ji58jbct 128 41 , , , cord-333405-ji58jbct 128 42 tuberculosis tuberculosis NN cord-333405-ji58jbct 128 43 , , , cord-333405-ji58jbct 128 44 protozoa protozoan NNS cord-333405-ji58jbct 128 45 and and CC cord-333405-ji58jbct 128 46 herpesviruses herpesviruses NNP cord-333405-ji58jbct 128 47 64 64 CD cord-333405-ji58jbct 128 48 . . . cord-333405-ji58jbct 129 1 Breakthroughs breakthrough NNS cord-333405-ji58jbct 129 2 in in IN cord-333405-ji58jbct 129 3 cancer cancer NN cord-333405-ji58jbct 129 4 therapy therapy NN cord-333405-ji58jbct 129 5 and and CC cord-333405-ji58jbct 129 6 in in IN cord-333405-ji58jbct 129 7 immunosuppressive immunosuppressive JJ cord-333405-ji58jbct 129 8 therapies therapy NNS cord-333405-ji58jbct 129 9 used use VBN cord-333405-ji58jbct 129 10 to to TO cord-333405-ji58jbct 129 11 treat treat VB cord-333405-ji58jbct 129 12 immune immune NN cord-333405-ji58jbct 129 13 - - HYPH cord-333405-ji58jbct 129 14 mediated mediate VBN cord-333405-ji58jbct 129 15 diseases disease NNS cord-333405-ji58jbct 129 16 and and CC cord-333405-ji58jbct 129 17 for for IN cord-333405-ji58jbct 129 18 transplantation transplantation NN cord-333405-ji58jbct 129 19 65 65 CD cord-333405-ji58jbct 129 20 , , , cord-333405-ji58jbct 129 21 66 66 CD cord-333405-ji58jbct 129 22 can can MD cord-333405-ji58jbct 129 23 also also RB cord-333405-ji58jbct 129 24 leave leave VB cord-333405-ji58jbct 129 25 patients patient NNS cord-333405-ji58jbct 129 26 susceptible susceptible JJ cord-333405-ji58jbct 129 27 to to IN cord-333405-ji58jbct 129 28 opportunistic opportunistic JJ cord-333405-ji58jbct 129 29 infections infection NNS cord-333405-ji58jbct 129 30 . . . cord-333405-ji58jbct 130 1 Human human JJ cord-333405-ji58jbct 130 2 organ organ NN cord-333405-ji58jbct 130 3 transplantation transplantation NN cord-333405-ji58jbct 130 4 adds add VBZ cord-333405-ji58jbct 130 5 a a DT cord-333405-ji58jbct 130 6 further further JJ cord-333405-ji58jbct 130 7 risk risk NN cord-333405-ji58jbct 130 8 of of IN cord-333405-ji58jbct 130 9 infection infection NN cord-333405-ji58jbct 130 10 with with IN cord-333405-ji58jbct 130 11 undetected undetected JJ cord-333405-ji58jbct 130 12 pathogens pathogen NNS cord-333405-ji58jbct 130 13 in in IN cord-333405-ji58jbct 130 14 donor donor NN cord-333405-ji58jbct 130 15 tissues tissue NNS cord-333405-ji58jbct 130 16 , , , cord-333405-ji58jbct 130 17 and and CC cord-333405-ji58jbct 130 18 transplantation transplantation NN cord-333405-ji58jbct 130 19 of of IN cord-333405-ji58jbct 130 20 animal animal NN cord-333405-ji58jbct 130 21 organs organ NNS cord-333405-ji58jbct 130 22 introduces introduce VBZ cord-333405-ji58jbct 130 23 the the DT cord-333405-ji58jbct 130 24 risk risk NN cord-333405-ji58jbct 130 25 of of IN cord-333405-ji58jbct 130 26 transmission transmission NN cord-333405-ji58jbct 130 27 to to IN cord-333405-ji58jbct 130 28 humans human NNS cord-333405-ji58jbct 130 29 of of IN cord-333405-ji58jbct 130 30 animal animal NN cord-333405-ji58jbct 130 31 microbes microbe NNS cord-333405-ji58jbct 130 32 67 67 CD cord-333405-ji58jbct 130 33 . . . cord-333405-ji58jbct 131 1 The the DT cord-333405-ji58jbct 131 2 emergence emergence NN cord-333405-ji58jbct 131 3 of of IN cord-333405-ji58jbct 131 4 zoonotic zoonotic JJ cord-333405-ji58jbct 131 5 and and CC cord-333405-ji58jbct 131 6 vector vector NN cord-333405-ji58jbct 131 7 - - HYPH cord-333405-ji58jbct 131 8 borne bear VBN cord-333405-ji58jbct 131 9 diseases disease NNS cord-333405-ji58jbct 131 10 can can MD cord-333405-ji58jbct 131 11 also also RB cord-333405-ji58jbct 131 12 be be VB cord-333405-ji58jbct 131 13 associated associate VBN cord-333405-ji58jbct 131 14 with with IN cord-333405-ji58jbct 131 15 human human JJ cord-333405-ji58jbct 131 16 behaviours behaviour NNS cord-333405-ji58jbct 131 17 and and CC cord-333405-ji58jbct 131 18 environmental environmental JJ cord-333405-ji58jbct 131 19 perturbation perturbation NN cord-333405-ji58jbct 131 20 . . . cord-333405-ji58jbct 132 1 Although although IN cord-333405-ji58jbct 132 2 West West NNP cord-333405-ji58jbct 132 3 Nile Nile NNP cord-333405-ji58jbct 132 4 virus virus NN cord-333405-ji58jbct 132 5 is be VBZ cord-333405-ji58jbct 132 6 now now RB cord-333405-ji58jbct 132 7 a a DT cord-333405-ji58jbct 132 8 major major JJ cord-333405-ji58jbct 132 9 epidemiological epidemiological JJ cord-333405-ji58jbct 132 10 concern concern NN cord-333405-ji58jbct 132 11 in in IN cord-333405-ji58jbct 132 12 the the DT cord-333405-ji58jbct 132 13 developed develop VBN cord-333405-ji58jbct 132 14 world world NN cord-333405-ji58jbct 132 15 , , , cord-333405-ji58jbct 132 16 dengue dengue NN cord-333405-ji58jbct 132 17 remains remain VBZ cord-333405-ji58jbct 132 18 the the DT cord-333405-ji58jbct 132 19 most most RBS cord-333405-ji58jbct 132 20 significant significant JJ cord-333405-ji58jbct 132 21 and and CC cord-333405-ji58jbct 132 22 widespread widespread JJ cord-333405-ji58jbct 132 23 flavivirus flavivirus JJ cord-333405-ji58jbct 132 24 disease disease NN cord-333405-ji58jbct 132 25 to to TO cord-333405-ji58jbct 132 26 have have VB cord-333405-ji58jbct 132 27 emerged emerge VBN cord-333405-ji58jbct 132 28 globally globally RB cord-333405-ji58jbct 132 29 71 71 CD cord-333405-ji58jbct 132 30 . . . cord-333405-ji58jbct 133 1 A a DT cord-333405-ji58jbct 133 2 2001 2001 CD cord-333405-ji58jbct 133 3 - - SYM cord-333405-ji58jbct 133 4 2002 2002 CD cord-333405-ji58jbct 133 5 epidemic epidemic NN cord-333405-ji58jbct 133 6 in in IN cord-333405-ji58jbct 133 7 Hawaii Hawaii NNP cord-333405-ji58jbct 133 8 -fortunately -fortunately RB cord-333405-ji58jbct 133 9 without without IN cord-333405-ji58jbct 133 10 fatalities fatality NNS cord-333405-ji58jbct 133 11 -is -is NFP cord-333405-ji58jbct 134 1 a a DT cord-333405-ji58jbct 134 2 reminder reminder NN cord-333405-ji58jbct 134 3 that that IN cord-333405-ji58jbct 134 4 dengue dengue NN cord-333405-ji58jbct 134 5 has have VBZ cord-333405-ji58jbct 134 6 also also RB cord-333405-ji58jbct 134 7 re re VBN cord-333405-ji58jbct 134 8 - - VBN cord-333405-ji58jbct 134 9 emerged emerge VBN cord-333405-ji58jbct 134 10 in in IN cord-333405-ji58jbct 134 11 locations location NNS cord-333405-ji58jbct 134 12 once once RB cord-333405-ji58jbct 134 13 considered consider VBN cord-333405-ji58jbct 134 14 to to TO cord-333405-ji58jbct 134 15 be be VB cord-333405-ji58jbct 134 16 dengue dengue NN cord-333405-ji58jbct 134 17 - - HYPH cord-333405-ji58jbct 134 18 free free JJ cord-333405-ji58jbct 134 19 . . . cord-333405-ji58jbct 135 1 Usually usually RB cord-333405-ji58jbct 135 2 transmitted transmit VBN cord-333405-ji58jbct 135 3 by by IN cord-333405-ji58jbct 135 4 Aedes Aedes NNP cord-333405-ji58jbct 135 5 aegypti aegypti NN cord-333405-ji58jbct 135 6 mosquitoes mosquito NNS cord-333405-ji58jbct 135 7 , , , cord-333405-ji58jbct 135 8 dengue dengue NN cord-333405-ji58jbct 135 9 has have VBZ cord-333405-ji58jbct 135 10 recently recently RB cord-333405-ji58jbct 135 11 been be VBN cord-333405-ji58jbct 135 12 transmitted transmit VBN cord-333405-ji58jbct 135 13 by by IN cord-333405-ji58jbct 135 14 Aedes Aedes NNP cord-333405-ji58jbct 135 15 albopictus albopictus NN cord-333405-ji58jbct 135 16 -a -a : cord-333405-ji58jbct 135 17 vector vector NN cord-333405-ji58jbct 135 18 switch switch NN cord-333405-ji58jbct 135 19 of of IN cord-333405-ji58jbct 135 20 potential potential JJ cord-333405-ji58jbct 135 21 significance significance NN cord-333405-ji58jbct 135 22 with with IN cord-333405-ji58jbct 135 23 respect respect NN cord-333405-ji58jbct 135 24 to to IN cord-333405-ji58jbct 135 25 dengue dengue NN cord-333405-ji58jbct 135 26 re re NN cord-333405-ji58jbct 135 27 - - NN cord-333405-ji58jbct 135 28 emergence emergence NN cord-333405-ji58jbct 135 29 71 71 CD cord-333405-ji58jbct 135 30 . . . cord-333405-ji58jbct 136 1 In in IN cord-333405-ji58jbct 136 2 the the DT cord-333405-ji58jbct 136 3 Americas Americas NNPS cord-333405-ji58jbct 136 4 , , , cord-333405-ji58jbct 136 5 including include VBG cord-333405-ji58jbct 136 6 many many JJ cord-333405-ji58jbct 136 7 US US NNP cord-333405-ji58jbct 136 8 southern southern JJ cord-333405-ji58jbct 136 9 states state NNS cord-333405-ji58jbct 136 10 , , , cord-333405-ji58jbct 136 11 A. A. NNP cord-333405-ji58jbct 136 12 albopictus albopictus NN cord-333405-ji58jbct 136 13 has have VBZ cord-333405-ji58jbct 136 14 been be VBN cord-333405-ji58jbct 136 15 spreading spread VBG cord-333405-ji58jbct 136 16 into into IN cord-333405-ji58jbct 136 17 areas area NNS cord-333405-ji58jbct 136 18 where where WRB cord-333405-ji58jbct 136 19 A. a. NN cord-333405-ji58jbct 136 20 aegypti aegypti NN cord-333405-ji58jbct 136 21 mosquitoes mosquito NNS cord-333405-ji58jbct 136 22 are be VBP cord-333405-ji58jbct 136 23 not not RB cord-333405-ji58jbct 136 24 found find VBN cord-333405-ji58jbct 136 25 , , , cord-333405-ji58jbct 136 26 and and CC cord-333405-ji58jbct 136 27 persisting persist VBG cord-333405-ji58jbct 136 28 for for IN cord-333405-ji58jbct 136 29 longer long JJR cord-333405-ji58jbct 136 30 seasonal seasonal JJ cord-333405-ji58jbct 136 31 periods period NNS cord-333405-ji58jbct 136 32 , , , cord-333405-ji58jbct 136 33 putting put VBG cord-333405-ji58jbct 136 34 tens ten NNS cord-333405-ji58jbct 136 35 of of IN cord-333405-ji58jbct 136 36 millions million NNS cord-333405-ji58jbct 136 37 more more JJR cord-333405-ji58jbct 136 38 people people NNS cord-333405-ji58jbct 136 39 at at IN cord-333405-ji58jbct 136 40 risk risk NN cord-333405-ji58jbct 136 41 of of IN cord-333405-ji58jbct 136 42 dengue dengue NN cord-333405-ji58jbct 136 43 infection infection NN cord-333405-ji58jbct 136 44 . . . cord-333405-ji58jbct 137 1 Dengue dengue NN cord-333405-ji58jbct 137 2 re re NN cord-333405-ji58jbct 137 3 - - NN cord-333405-ji58jbct 137 4 emergence emergence NN cord-333405-ji58jbct 137 5 is be VBZ cord-333405-ji58jbct 137 6 further far RBR cord-333405-ji58jbct 137 7 complicated complicate VBN cord-333405-ji58jbct 137 8 by by IN cord-333405-ji58jbct 137 9 disturbing disturb VBG cord-333405-ji58jbct 137 10 increases increase NNS cord-333405-ji58jbct 137 11 in in IN cord-333405-ji58jbct 137 12 a a DT cord-333405-ji58jbct 137 13 serious serious JJ cord-333405-ji58jbct 137 14 and and CC cord-333405-ji58jbct 137 15 formerly formerly RB cord-333405-ji58jbct 137 16 rare rare JJ cord-333405-ji58jbct 137 17 form form NN cord-333405-ji58jbct 137 18 of of IN cord-333405-ji58jbct 137 19 the the DT cord-333405-ji58jbct 137 20 disease disease NN cord-333405-ji58jbct 137 21 , , , cord-333405-ji58jbct 137 22 dengue dengue NN cord-333405-ji58jbct 137 23 haemorrhagic haemorrhagic JJ cord-333405-ji58jbct 137 24 fever fever NN cord-333405-ji58jbct 137 25 ( ( -LRB- cord-333405-ji58jbct 137 26 dengue dengue NN cord-333405-ji58jbct 137 27 shock shock NN cord-333405-ji58jbct 137 28 syndrome syndrome NN cord-333405-ji58jbct 137 29 being be VBG cord-333405-ji58jbct 137 30 its -PRON- PRP$ cord-333405-ji58jbct 137 31 highly highly RB cord-333405-ji58jbct 137 32 fatal fatal JJ cord-333405-ji58jbct 137 33 form form NN cord-333405-ji58jbct 137 34 ) ) -RRB- cord-333405-ji58jbct 137 35 . . . cord-333405-ji58jbct 138 1 These these DT cord-333405-ji58jbct 138 2 severe severe JJ cord-333405-ji58jbct 138 3 complications complication NNS cord-333405-ji58jbct 138 4 are be VBP cord-333405-ji58jbct 138 5 thought think VBN cord-333405-ji58jbct 138 6 to to TO cord-333405-ji58jbct 138 7 result result VB cord-333405-ji58jbct 138 8 from from IN cord-333405-ji58jbct 138 9 the the DT cord-333405-ji58jbct 138 10 evolution evolution NN cord-333405-ji58jbct 138 11 of of IN cord-333405-ji58jbct 138 12 dengue dengue NN cord-333405-ji58jbct 138 13 viruses virus NNS cord-333405-ji58jbct 138 14 to to TO cord-333405-ji58jbct 138 15 escape escape VB cord-333405-ji58jbct 138 16 high high JJ cord-333405-ji58jbct 138 17 insight insight NN cord-333405-ji58jbct 138 18 review review NN cord-333405-ji58jbct 138 19 articles article NNS cord-333405-ji58jbct 138 20 246 246 CD cord-333405-ji58jbct 138 21 NATURE NATURE NNP cord-333405-ji58jbct 138 22 | | HYPH cord-333405-ji58jbct 138 23 VOL VOL NNP cord-333405-ji58jbct 138 24 430 430 CD cord-333405-ji58jbct 138 25 | | NNP cord-333405-ji58jbct 138 26 8 8 CD cord-333405-ji58jbct 138 27 JULY JULY NNP cord-333405-ji58jbct 138 28 2004 2004 CD cord-333405-ji58jbct 138 29 | | NNP cord-333405-ji58jbct 138 30 www.nature.com/nature www.nature.com/nature NNP cord-333405-ji58jbct 138 31 population population NN cord-333405-ji58jbct 138 32 immunity immunity NN cord-333405-ji58jbct 138 33 , , , cord-333405-ji58jbct 138 34 seen see VBN cord-333405-ji58jbct 138 35 in in IN cord-333405-ji58jbct 138 36 increased increase VBN cord-333405-ji58jbct 138 37 viral viral JJ cord-333405-ji58jbct 138 38 virulence virulence NN cord-333405-ji58jbct 138 39 and and CC cord-333405-ji58jbct 138 40 human human JJ cord-333405-ji58jbct 138 41 immunopathogenesis immunopathogenesis NN cord-333405-ji58jbct 138 42 due due IN cord-333405-ji58jbct 138 43 to to IN cord-333405-ji58jbct 138 44 antibody antibody NN cord-333405-ji58jbct 138 45 - - HYPH cord-333405-ji58jbct 138 46 dependent dependent JJ cord-333405-ji58jbct 138 47 enhancement enhancement NN cord-333405-ji58jbct 138 48 of of IN cord-333405-ji58jbct 138 49 viral viral JJ cord-333405-ji58jbct 138 50 infection infection NN cord-333405-ji58jbct 138 51 72 72 CD cord-333405-ji58jbct 138 52 . . . cord-333405-ji58jbct 139 1 Cholera cholera NN cord-333405-ji58jbct 139 2 is be VBZ cord-333405-ji58jbct 139 3 also also RB cord-333405-ji58jbct 139 4 of of IN cord-333405-ji58jbct 139 5 interest interest NN cord-333405-ji58jbct 139 6 , , , cord-333405-ji58jbct 139 7 not not RB cord-333405-ji58jbct 139 8 only only RB cord-333405-ji58jbct 139 9 as as IN cord-333405-ji58jbct 139 10 an an DT cord-333405-ji58jbct 139 11 important important JJ cord-333405-ji58jbct 139 12 cause cause NN cord-333405-ji58jbct 139 13 of of IN cord-333405-ji58jbct 139 14 mortality mortality NN cord-333405-ji58jbct 139 15 , , , cord-333405-ji58jbct 139 16 but but CC cord-333405-ji58jbct 139 17 also also RB cord-333405-ji58jbct 139 18 because because IN cord-333405-ji58jbct 139 19 of of IN cord-333405-ji58jbct 139 20 the the DT cord-333405-ji58jbct 139 21 complexity complexity NN cord-333405-ji58jbct 139 22 of of IN cord-333405-ji58jbct 139 23 factors factor NNS cord-333405-ji58jbct 139 24 that that WDT cord-333405-ji58jbct 139 25 determine determine VBP cord-333405-ji58jbct 139 26 its -PRON- PRP$ cord-333405-ji58jbct 139 27 re re NN cord-333405-ji58jbct 139 28 - - NN cord-333405-ji58jbct 139 29 emergence emergence NN cord-333405-ji58jbct 139 30 . . . cord-333405-ji58jbct 140 1 Both both DT cord-333405-ji58jbct 140 2 virulent virulent JJ cord-333405-ji58jbct 140 3 and and CC cord-333405-ji58jbct 140 4 avirulent avirulent JJ cord-333405-ji58jbct 140 5 strains strain NNS cord-333405-ji58jbct 140 6 of of IN cord-333405-ji58jbct 140 7 these these DT cord-333405-ji58jbct 140 8 zoonotic zoonotic JJ cord-333405-ji58jbct 140 9 bacteria bacteria NNS cord-333405-ji58jbct 140 10 are be VBP cord-333405-ji58jbct 140 11 maintained maintain VBN cord-333405-ji58jbct 140 12 in in IN cord-333405-ji58jbct 140 13 the the DT cord-333405-ji58jbct 140 14 environment environment NN cord-333405-ji58jbct 140 15 and and CC cord-333405-ji58jbct 140 16 are be VBP cord-333405-ji58jbct 140 17 rapidly rapidly RB cord-333405-ji58jbct 140 18 evolving evolve VBG cord-333405-ji58jbct 140 19 in in IN cord-333405-ji58jbct 140 20 association association NN cord-333405-ji58jbct 140 21 with with IN cord-333405-ji58jbct 140 22 phyto phyto NN cord-333405-ji58jbct 140 23 - - : cord-333405-ji58jbct 140 24 and and CC cord-333405-ji58jbct 140 25 zooplankton zooplankton NNS cord-333405-ji58jbct 140 26 , , , cord-333405-ji58jbct 140 27 algae algae NN cord-333405-ji58jbct 140 28 and and CC cord-333405-ji58jbct 140 29 crustaceans crustacean NNS cord-333405-ji58jbct 140 30 . . . cord-333405-ji58jbct 141 1 Such such JJ cord-333405-ji58jbct 141 2 environmental environmental JJ cord-333405-ji58jbct 141 3 strains strain NNS cord-333405-ji58jbct 141 4 seem seem VBP cord-333405-ji58jbct 141 5 to to TO cord-333405-ji58jbct 141 6 act act VB cord-333405-ji58jbct 141 7 as as IN cord-333405-ji58jbct 141 8 reservoirs reservoir NNS cord-333405-ji58jbct 141 9 for for IN cord-333405-ji58jbct 141 10 human human JJ cord-333405-ji58jbct 141 11 virulence virulence NN cord-333405-ji58jbct 141 12 genes gene NNS cord-333405-ji58jbct 141 13 ( ( -LRB- cord-333405-ji58jbct 141 14 for for IN cord-333405-ji58jbct 141 15 example example NN cord-333405-ji58jbct 141 16 , , , cord-333405-ji58jbct 141 17 genes gene NNS cord-333405-ji58jbct 141 18 for for IN cord-333405-ji58jbct 141 19 the the DT cord-333405-ji58jbct 141 20 phage phage NN cord-333405-ji58jbct 141 21 - - HYPH cord-333405-ji58jbct 141 22 encoded encode VBN cord-333405-ji58jbct 141 23 cholera cholera NN cord-333405-ji58jbct 141 24 toxin toxin NN cord-333405-ji58jbct 141 25 and and CC cord-333405-ji58jbct 141 26 the the DT cord-333405-ji58jbct 141 27 toxin toxin NN cord-333405-ji58jbct 141 28 - - HYPH cord-333405-ji58jbct 141 29 coregulated coregulate VBN cord-333405-ji58jbct 141 30 pilus pilus NN cord-333405-ji58jbct 141 31 ( ( -LRB- cord-333405-ji58jbct 141 32 TCP TCP NNP cord-333405-ji58jbct 141 33 ) ) -RRB- cord-333405-ji58jbct 141 34 factor factor NN cord-333405-ji58jbct 141 35 associated associate VBN cord-333405-ji58jbct 141 36 with with IN cord-333405-ji58jbct 141 37 attachment attachment NN cord-333405-ji58jbct 141 38 ) ) -RRB- cord-333405-ji58jbct 141 39 , , , cord-333405-ji58jbct 141 40 and and CC cord-333405-ji58jbct 141 41 to to TO cord-333405-ji58jbct 141 42 undergo undergo VB cord-333405-ji58jbct 141 43 gene gene NN cord-333405-ji58jbct 141 44 transfer transfer NN cord-333405-ji58jbct 141 45 events event NNS cord-333405-ji58jbct 141 46 that that WDT cord-333405-ji58jbct 141 47 lead lead VBP cord-333405-ji58jbct 141 48 to to IN cord-333405-ji58jbct 141 49 new new JJ cord-333405-ji58jbct 141 50 strains strain NNS cord-333405-ji58jbct 141 51 containing contain VBG cord-333405-ji58jbct 141 52 further further JJ cord-333405-ji58jbct 141 53 virulence virulence NN cord-333405-ji58jbct 141 54 gene gene NN cord-333405-ji58jbct 141 55 combinations combination NNS cord-333405-ji58jbct 141 56 . . . cord-333405-ji58jbct 142 1 These these DT cord-333405-ji58jbct 142 2 result result VBP cord-333405-ji58jbct 142 3 in in IN cord-333405-ji58jbct 142 4 periodic periodic JJ cord-333405-ji58jbct 142 5 cholera cholera NN cord-333405-ji58jbct 142 6 emergences emergence NNS cord-333405-ji58jbct 142 7 that that WDT cord-333405-ji58jbct 142 8 cause cause VBP cord-333405-ji58jbct 142 9 epidemics epidemic NNS cord-333405-ji58jbct 142 10 and and CC cord-333405-ji58jbct 142 11 pandemics pandemic NNS cord-333405-ji58jbct 142 12 73 73 CD cord-333405-ji58jbct 142 13 . . . cord-333405-ji58jbct 143 1 Thus thus RB cord-333405-ji58jbct 143 2 , , , cord-333405-ji58jbct 143 3 although although IN cord-333405-ji58jbct 143 4 the the DT cord-333405-ji58jbct 143 5 disease disease NN cord-333405-ji58jbct 143 6 we -PRON- PRP cord-333405-ji58jbct 143 7 know know VBP cord-333405-ji58jbct 143 8 as as IN cord-333405-ji58jbct 143 9 cholera cholera NN cord-333405-ji58jbct 143 10 has have VBZ cord-333405-ji58jbct 143 11 appeared appear VBN cord-333405-ji58jbct 143 12 to to TO cord-333405-ji58jbct 143 13 be be VB cord-333405-ji58jbct 143 14 clinically clinically RB cord-333405-ji58jbct 143 15 and and CC cord-333405-ji58jbct 143 16 epidemiologically epidemiologically RB cord-333405-ji58jbct 143 17 stable stable JJ cord-333405-ji58jbct 143 18 at at IN cord-333405-ji58jbct 143 19 least least JJS cord-333405-ji58jbct 143 20 since since IN cord-333405-ji58jbct 143 21 the the DT cord-333405-ji58jbct 143 22 third third JJ cord-333405-ji58jbct 143 23 pandemic pandemic NN cord-333405-ji58jbct 143 24 ( ( -LRB- cord-333405-ji58jbct 143 25 in in IN cord-333405-ji58jbct 143 26 the the DT cord-333405-ji58jbct 143 27 1840s 1840s CD cord-333405-ji58jbct 143 28 ) ) -RRB- cord-333405-ji58jbct 143 29 , , , cord-333405-ji58jbct 143 30 modern modern JJ cord-333405-ji58jbct 143 31 evidence evidence NN cord-333405-ji58jbct 143 32 suggests suggest VBZ cord-333405-ji58jbct 143 33 that that IN cord-333405-ji58jbct 143 34 such such JJ cord-333405-ji58jbct 143 35 apparent apparent JJ cord-333405-ji58jbct 143 36 stability stability NN cord-333405-ji58jbct 143 37 masks mask NNS cord-333405-ji58jbct 143 38 aggressive aggressive JJ cord-333405-ji58jbct 143 39 bacterial bacterial JJ cord-333405-ji58jbct 143 40 evolution evolution NN cord-333405-ji58jbct 143 41 in in IN cord-333405-ji58jbct 143 42 complex complex JJ cord-333405-ji58jbct 143 43 natural natural JJ cord-333405-ji58jbct 143 44 environments environment NNS cord-333405-ji58jbct 143 45 . . . cord-333405-ji58jbct 144 1 Influenza Influenza NNP cord-333405-ji58jbct 144 2 A a DT cord-333405-ji58jbct 144 3 viruses virus NNS cord-333405-ji58jbct 144 4 , , , cord-333405-ji58jbct 144 5 which which WDT cord-333405-ji58jbct 144 6 are be VBP cord-333405-ji58jbct 144 7 endemic endemic JJ cord-333405-ji58jbct 144 8 gastrointestinal gastrointestinal JJ cord-333405-ji58jbct 144 9 viruses virus NNS cord-333405-ji58jbct 144 10 of of IN cord-333405-ji58jbct 144 11 wild wild JJ cord-333405-ji58jbct 144 12 waterfowl waterfowl NNS cord-333405-ji58jbct 144 13 , , , cord-333405-ji58jbct 144 14 have have VBP cord-333405-ji58jbct 144 15 evolved evolve VBN cord-333405-ji58jbct 144 16 elaborate elaborate JJ cord-333405-ji58jbct 144 17 mechanisms mechanism NNS cord-333405-ji58jbct 144 18 to to TO cord-333405-ji58jbct 144 19 jump jump VB cord-333405-ji58jbct 144 20 species specie NNS cord-333405-ji58jbct 144 21 into into IN cord-333405-ji58jbct 144 22 domestic domestic JJ cord-333405-ji58jbct 144 23 fowl fowl NN cord-333405-ji58jbct 144 24 , , , cord-333405-ji58jbct 144 25 farm farm NN cord-333405-ji58jbct 144 26 animals animal NNS cord-333405-ji58jbct 144 27 and and CC cord-333405-ji58jbct 144 28 humans human NNS cord-333405-ji58jbct 144 29 . . . cord-333405-ji58jbct 145 1 Periodic periodic JJ cord-333405-ji58jbct 145 2 gene gene NN cord-333405-ji58jbct 145 3 segment segment NN cord-333405-ji58jbct 145 4 reassortments reassortment NNS cord-333405-ji58jbct 145 5 between between IN cord-333405-ji58jbct 145 6 human human NN cord-333405-ji58jbct 145 7 and and CC cord-333405-ji58jbct 145 8 animal animal NN cord-333405-ji58jbct 145 9 viruses virus NNS cord-333405-ji58jbct 145 10 produce produce VBP cord-333405-ji58jbct 145 11 important important JJ cord-333405-ji58jbct 145 12 antigenic antigenic JJ cord-333405-ji58jbct 145 13 changes change NNS cord-333405-ji58jbct 145 14 , , , cord-333405-ji58jbct 145 15 referred refer VBD cord-333405-ji58jbct 145 16 to to IN cord-333405-ji58jbct 145 17 as as IN cord-333405-ji58jbct 145 18 ' ' `` cord-333405-ji58jbct 145 19 shifts shift NNS cord-333405-ji58jbct 145 20 ' ' '' cord-333405-ji58jbct 145 21 . . . cord-333405-ji58jbct 146 1 These these DT cord-333405-ji58jbct 146 2 can can MD cord-333405-ji58jbct 146 3 lead lead VB cord-333405-ji58jbct 146 4 to to IN cord-333405-ji58jbct 146 5 deadly deadly JJ cord-333405-ji58jbct 146 6 pandemics pandemic NNS cord-333405-ji58jbct 146 7 , , , cord-333405-ji58jbct 146 8 as as IN cord-333405-ji58jbct 146 9 occurred occur VBD cord-333405-ji58jbct 146 10 in in IN cord-333405-ji58jbct 146 11 1888 1888 CD cord-333405-ji58jbct 146 12 , , , cord-333405-ji58jbct 146 13 1918 1918 CD cord-333405-ji58jbct 146 14 , , , cord-333405-ji58jbct 146 15 1957 1957 CD cord-333405-ji58jbct 146 16 and and CC cord-333405-ji58jbct 146 17 1968 1968 CD cord-333405-ji58jbct 147 1 ( ( -LRB- cord-333405-ji58jbct 147 2 refs refs NNP cord-333405-ji58jbct 147 3 74 74 CD cord-333405-ji58jbct 147 4 , , , cord-333405-ji58jbct 147 5 75 75 CD cord-333405-ji58jbct 147 6 ) ) -RRB- cord-333405-ji58jbct 147 7 . . . cord-333405-ji58jbct 148 1 In in IN cord-333405-ji58jbct 148 2 intervening intervene VBG cord-333405-ji58jbct 148 3 years year NNS cord-333405-ji58jbct 148 4 , , , cord-333405-ji58jbct 148 5 shifted shift VBD cord-333405-ji58jbct 148 6 viruses virus NNS cord-333405-ji58jbct 148 7 undergo undergo VBP cord-333405-ji58jbct 148 8 continual continual JJ cord-333405-ji58jbct 148 9 but but CC cord-333405-ji58jbct 148 10 less less RBR cord-333405-ji58jbct 148 11 dramatic dramatic JJ cord-333405-ji58jbct 148 12 antigenic antigenic JJ cord-333405-ji58jbct 148 13 changes change NNS cord-333405-ji58jbct 148 14 called call VBD cord-333405-ji58jbct 148 15 ' ' `` cord-333405-ji58jbct 148 16 drifts drift NNS cord-333405-ji58jbct 148 17 ' ' '' cord-333405-ji58jbct 148 18 , , , cord-333405-ji58jbct 148 19 which which WDT cord-333405-ji58jbct 148 20 allow allow VBP cord-333405-ji58jbct 148 21 them -PRON- PRP cord-333405-ji58jbct 148 22 partially partially RB cord-333405-ji58jbct 148 23 to to TO cord-333405-ji58jbct 148 24 escape escape VB cord-333405-ji58jbct 148 25 human human JJ cord-333405-ji58jbct 148 26 immunity immunity NN cord-333405-ji58jbct 148 27 raised raise VBN cord-333405-ji58jbct 148 28 by by IN cord-333405-ji58jbct 148 29 previously previously RB cord-333405-ji58jbct 148 30 circulating circulate VBG cord-333405-ji58jbct 148 31 influenza influenza NN cord-333405-ji58jbct 148 32 viruses virus NNS cord-333405-ji58jbct 148 33 . . . cord-333405-ji58jbct 149 1 Influenza Influenza NNP cord-333405-ji58jbct 149 2 drift drift NN cord-333405-ji58jbct 149 3 is be VBZ cord-333405-ji58jbct 149 4 an an DT cord-333405-ji58jbct 149 5 evolutionary evolutionary JJ cord-333405-ji58jbct 149 6 success success NN cord-333405-ji58jbct 149 7 story story NN cord-333405-ji58jbct 149 8 for for IN cord-333405-ji58jbct 149 9 the the DT cord-333405-ji58jbct 149 10 virus virus NN cord-333405-ji58jbct 149 11 . . . cord-333405-ji58jbct 150 1 Influenza Influenza NNP cord-333405-ji58jbct 150 2 A A NNP cord-333405-ji58jbct 150 3 has have VBZ cord-333405-ji58jbct 150 4 a a DT cord-333405-ji58jbct 150 5 seemingly seemingly RB cord-333405-ji58jbct 150 6 inexhaustible inexhaustible JJ cord-333405-ji58jbct 150 7 repertoire repertoire NN cord-333405-ji58jbct 150 8 of of IN cord-333405-ji58jbct 150 9 mutational mutational JJ cord-333405-ji58jbct 150 10 possibilities possibility NNS cord-333405-ji58jbct 150 11 at at IN cord-333405-ji58jbct 150 12 several several JJ cord-333405-ji58jbct 150 13 critical critical JJ cord-333405-ji58jbct 150 14 epitopes epitope NNS cord-333405-ji58jbct 150 15 surrounding surround VBG cord-333405-ji58jbct 150 16 the the DT cord-333405-ji58jbct 150 17 viral viral JJ cord-333405-ji58jbct 150 18 haemagglutinin haemagglutinin NNP cord-333405-ji58jbct 150 19 site site NN cord-333405-ji58jbct 150 20 that that WDT cord-333405-ji58jbct 150 21 attaches attach VBZ cord-333405-ji58jbct 150 22 to to IN cord-333405-ji58jbct 150 23 human human JJ cord-333405-ji58jbct 150 24 cells cell NNS cord-333405-ji58jbct 150 25 . . . cord-333405-ji58jbct 151 1 It -PRON- PRP cord-333405-ji58jbct 151 2 remains remain VBZ cord-333405-ji58jbct 151 3 something something NN cord-333405-ji58jbct 151 4 of of IN cord-333405-ji58jbct 151 5 a a DT cord-333405-ji58jbct 151 6 mystery mystery NN cord-333405-ji58jbct 151 7 how how WRB cord-333405-ji58jbct 151 8 zoonotic zoonotic JJ cord-333405-ji58jbct 151 9 influenza influenza NN cord-333405-ji58jbct 151 10 viruses virus NNS cord-333405-ji58jbct 151 11 mix mix VBP cord-333405-ji58jbct 151 12 with with IN cord-333405-ji58jbct 151 13 each each DT cord-333405-ji58jbct 151 14 other other JJ cord-333405-ji58jbct 151 15 and and CC cord-333405-ji58jbct 151 16 with with IN cord-333405-ji58jbct 151 17 human human JJ cord-333405-ji58jbct 151 18 strains strain NNS cord-333405-ji58jbct 151 19 to to TO cord-333405-ji58jbct 151 20 acquire acquire VB cord-333405-ji58jbct 151 21 the the DT cord-333405-ji58jbct 151 22 additional additional JJ cord-333405-ji58jbct 151 23 properties property NNS cord-333405-ji58jbct 151 24 of of IN cord-333405-ji58jbct 151 25 human human JJ cord-333405-ji58jbct 151 26 virulence virulence NN cord-333405-ji58jbct 151 27 and and CC cord-333405-ji58jbct 151 28 human human NN cord-333405-ji58jbct 151 29 - - HYPH cord-333405-ji58jbct 151 30 to to IN cord-333405-ji58jbct 151 31 - - HYPH cord-333405-ji58jbct 151 32 human human JJ cord-333405-ji58jbct 151 33 transmissibility transmissibility NN cord-333405-ji58jbct 151 34 . . . cord-333405-ji58jbct 152 1 Before before IN cord-333405-ji58jbct 152 2 1997 1997 CD cord-333405-ji58jbct 152 3 , , , cord-333405-ji58jbct 152 4 mild mild JJ cord-333405-ji58jbct 152 5 cases case NNS cord-333405-ji58jbct 152 6 of of IN cord-333405-ji58jbct 152 7 human human JJ cord-333405-ji58jbct 152 8 disease disease NN cord-333405-ji58jbct 152 9 associated associate VBN cord-333405-ji58jbct 152 10 with with IN cord-333405-ji58jbct 152 11 avian avian JJ cord-333405-ji58jbct 152 12 influenza influenza NN cord-333405-ji58jbct 152 13 viruses virus NNS cord-333405-ji58jbct 152 14 were be VBD cord-333405-ji58jbct 152 15 occasionally occasionally RB cord-333405-ji58jbct 152 16 reported report VBN cord-333405-ji58jbct 152 17 76 76 CD cord-333405-ji58jbct 152 18 . . . cord-333405-ji58jbct 153 1 These these DT cord-333405-ji58jbct 153 2 events event NNS cord-333405-ji58jbct 153 3 have have VBP cord-333405-ji58jbct 153 4 become become VBN cord-333405-ji58jbct 153 5 more more RBR cord-333405-ji58jbct 153 6 frequent frequent JJ cord-333405-ji58jbct 153 7 , , , cord-333405-ji58jbct 153 8 sometimes sometimes RB cord-333405-ji58jbct 153 9 resulting result VBG cord-333405-ji58jbct 153 10 in in IN cord-333405-ji58jbct 153 11 severe severe JJ cord-333405-ji58jbct 153 12 cases case NNS cord-333405-ji58jbct 153 13 of of IN cord-333405-ji58jbct 153 14 disease disease NN cord-333405-ji58jbct 153 15 and and CC cord-333405-ji58jbct 153 16 death death NN cord-333405-ji58jbct 153 17 . . . cord-333405-ji58jbct 154 1 Avian avian JJ cord-333405-ji58jbct 154 2 influenza influenza NN cord-333405-ji58jbct 154 3 has have VBZ cord-333405-ji58jbct 154 4 recently recently RB cord-333405-ji58jbct 154 5 made make VBN cord-333405-ji58jbct 154 6 dead dead JJ cord-333405-ji58jbct 154 7 - - HYPH cord-333405-ji58jbct 154 8 end end NN cord-333405-ji58jbct 154 9 jumps jump VBZ cord-333405-ji58jbct 154 10 to to IN cord-333405-ji58jbct 154 11 humans human NNS cord-333405-ji58jbct 154 12 -for -for ADD cord-333405-ji58jbct 155 1 example example NN cord-333405-ji58jbct 155 2 , , , cord-333405-ji58jbct 155 3 the the DT cord-333405-ji58jbct 155 4 1997 1997 CD cord-333405-ji58jbct 155 5 Hong Hong NNP cord-333405-ji58jbct 155 6 Kong Kong NNP cord-333405-ji58jbct 155 7 outbreak outbreak NN cord-333405-ji58jbct 155 8 of of IN cord-333405-ji58jbct 155 9 the the DT cord-333405-ji58jbct 155 10 newly newly RB cord-333405-ji58jbct 155 11 emergent emergent JJ cord-333405-ji58jbct 155 12 H5N1 H5N1 NNP cord-333405-ji58jbct 155 13 influenza influenza NN cord-333405-ji58jbct 155 14 , , , cord-333405-ji58jbct 155 15 the the DT cord-333405-ji58jbct 155 16 2003 2003 CD cord-333405-ji58jbct 155 17 H7N7 H7N7 NNP cord-333405-ji58jbct 155 18 epidemic epidemic NN cord-333405-ji58jbct 155 19 in in IN cord-333405-ji58jbct 155 20 the the DT cord-333405-ji58jbct 155 21 Netherlands Netherlands NNP cord-333405-ji58jbct 155 22 , , , cord-333405-ji58jbct 155 23 the the DT cord-333405-ji58jbct 155 24 2003 2003 CD cord-333405-ji58jbct 155 25 - - SYM cord-333405-ji58jbct 155 26 2004 2004 CD cord-333405-ji58jbct 155 27 H5N1 H5N1 NNP cord-333405-ji58jbct 155 28 and and CC cord-333405-ji58jbct 155 29 H7N3 H7N3 NNP cord-333405-ji58jbct 155 30 epizootics epizootic NNS cord-333405-ji58jbct 155 31 in in IN cord-333405-ji58jbct 155 32 Asia Asia NNP cord-333405-ji58jbct 155 33 and and CC cord-333405-ji58jbct 155 34 elsewhere elsewhere RB cord-333405-ji58jbct 155 35 , , , cord-333405-ji58jbct 155 36 and and CC cord-333405-ji58jbct 155 37 occasional occasional JJ cord-333405-ji58jbct 155 38 cases case NNS cord-333405-ji58jbct 155 39 of of IN cord-333405-ji58jbct 155 40 H9N2 H9N2 NNP cord-333405-ji58jbct 155 41 disease disease NN cord-333405-ji58jbct 155 42 ( ( -LRB- cord-333405-ji58jbct 155 43 Fig fig NN cord-333405-ji58jbct 155 44 . . NNP cord-333405-ji58jbct 155 45 4 4 CD cord-333405-ji58jbct 155 46 ) ) -RRB- cord-333405-ji58jbct 155 47 . . . cord-333405-ji58jbct 156 1 Meanwhile meanwhile RB cord-333405-ji58jbct 156 2 , , , cord-333405-ji58jbct 156 3 back back RB cord-333405-ji58jbct 156 4 - - HYPH cord-333405-ji58jbct 156 5 switches switch NNS cord-333405-ji58jbct 156 6 of of IN cord-333405-ji58jbct 156 7 human human JJ cord-333405-ji58jbct 156 8 H3N2 H3N2 NNP cord-333405-ji58jbct 156 9 viruses virus NNS cord-333405-ji58jbct 156 10 have have VBP cord-333405-ji58jbct 156 11 emerged emerge VBN cord-333405-ji58jbct 156 12 in in IN cord-333405-ji58jbct 156 13 pigs pig NNS cord-333405-ji58jbct 156 14 , , , cord-333405-ji58jbct 156 15 from from IN cord-333405-ji58jbct 156 16 which which WDT cord-333405-ji58jbct 156 17 both both DT cord-333405-ji58jbct 156 18 doubly doubly RB cord-333405-ji58jbct 156 19 mixed mixed JJ cord-333405-ji58jbct 156 20 ( ( -LRB- cord-333405-ji58jbct 156 21 pig pig NN cord-333405-ji58jbct 156 22 - - HYPH cord-333405-ji58jbct 156 23 human human NN cord-333405-ji58jbct 156 24 ) ) -RRB- cord-333405-ji58jbct 156 25 and and CC cord-333405-ji58jbct 156 26 triply triply RB cord-333405-ji58jbct 156 27 mixed mixed JJ cord-333405-ji58jbct 156 28 ( ( -LRB- cord-333405-ji58jbct 156 29 pig pig NN cord-333405-ji58jbct 156 30 - - HYPH cord-333405-ji58jbct 156 31 human human JJ cord-333405-ji58jbct 156 32 - - HYPH cord-333405-ji58jbct 156 33 avian avian JJ cord-333405-ji58jbct 156 34 ) ) -RRB- cord-333405-ji58jbct 156 35 viruses virus NNS cord-333405-ji58jbct 156 36 74 74 CD cord-333405-ji58jbct 156 37 , , , cord-333405-ji58jbct 156 38 75 75 CD cord-333405-ji58jbct 156 39 have have VBP cord-333405-ji58jbct 156 40 been be VBN cord-333405-ji58jbct 156 41 isolated isolate VBN cord-333405-ji58jbct 156 42 . . . cord-333405-ji58jbct 157 1 Such such JJ cord-333405-ji58jbct 157 2 enzootic enzootic JJ cord-333405-ji58jbct 157 3 / / SYM cord-333405-ji58jbct 157 4 zoonotic zoonotic JJ cord-333405-ji58jbct 157 5 mixing mixing NN cord-333405-ji58jbct 157 6 is be VBZ cord-333405-ji58jbct 157 7 suspected suspect VBN cord-333405-ji58jbct 157 8 to to TO cord-333405-ji58jbct 157 9 have have VB cord-333405-ji58jbct 157 10 occurred occur VBN cord-333405-ji58jbct 157 11 in in IN cord-333405-ji58jbct 157 12 the the DT cord-333405-ji58jbct 157 13 influenza influenza NN cord-333405-ji58jbct 157 14 pandemic pandemic NN cord-333405-ji58jbct 157 15 of of IN cord-333405-ji58jbct 157 16 1918 1918 CD cord-333405-ji58jbct 157 17 - - SYM cord-333405-ji58jbct 157 18 1920 1920 CD cord-333405-ji58jbct 157 19 , , , cord-333405-ji58jbct 157 20 which which WDT cord-333405-ji58jbct 157 21 was be VBD cord-333405-ji58jbct 157 22 caused cause VBN cord-333405-ji58jbct 157 23 by by IN cord-333405-ji58jbct 157 24 an an DT cord-333405-ji58jbct 157 25 H1N1 H1N1 NNP cord-333405-ji58jbct 157 26 virus virus NN cord-333405-ji58jbct 157 27 with with IN cord-333405-ji58jbct 157 28 an an DT cord-333405-ji58jbct 157 29 avian avian JJ cord-333405-ji58jbct 157 30 - - HYPH cord-333405-ji58jbct 157 31 like like JJ cord-333405-ji58jbct 157 32 receptor receptor NN cord-333405-ji58jbct 157 33 - - HYPH cord-333405-ji58jbct 157 34 binding bind VBG cord-333405-ji58jbct 157 35 site site NN cord-333405-ji58jbct 157 36 77 77 CD cord-333405-ji58jbct 157 37 . . . cord-333405-ji58jbct 158 1 The the DT cord-333405-ji58jbct 158 2 predicted predict VBN cord-333405-ji58jbct 158 3 virulence virulence NN cord-333405-ji58jbct 158 4 genes gene NNS cord-333405-ji58jbct 158 5 of of IN cord-333405-ji58jbct 158 6 this this DT cord-333405-ji58jbct 158 7 virus virus NN cord-333405-ji58jbct 158 8 are be VBP cord-333405-ji58jbct 158 9 now now RB cord-333405-ji58jbct 158 10 being be VBG cord-333405-ji58jbct 158 11 sought seek VBN cord-333405-ji58jbct 158 12 from from IN cord-333405-ji58jbct 158 13 85-year 85-year JJ cord-333405-ji58jbct 158 14 - - HYPH cord-333405-ji58jbct 158 15 old old JJ cord-333405-ji58jbct 158 16 pathology pathology NN cord-333405-ji58jbct 158 17 specimens specimen NNS cord-333405-ji58jbct 158 18 and and CC cord-333405-ji58jbct 158 19 from from IN cord-333405-ji58jbct 158 20 frozen frozen JJ cord-333405-ji58jbct 158 21 corpses corpse NNS cord-333405-ji58jbct 158 22 78 78 CD cord-333405-ji58jbct 158 23 . . . cord-333405-ji58jbct 159 1 The the DT cord-333405-ji58jbct 159 2 implications implication NNS cord-333405-ji58jbct 159 3 of of IN cord-333405-ji58jbct 159 4 interspecies interspecie NNS cord-333405-ji58jbct 159 5 genetic genetic JJ cord-333405-ji58jbct 159 6 mixing mixing NN cord-333405-ji58jbct 159 7 for for IN cord-333405-ji58jbct 159 8 future future JJ cord-333405-ji58jbct 159 9 influenza influenza NN cord-333405-ji58jbct 159 10 pandemics pandemic NNS cord-333405-ji58jbct 159 11 are be VBP cord-333405-ji58jbct 159 12 troubling troubling JJ cord-333405-ji58jbct 159 13 . . . cord-333405-ji58jbct 160 1 Although although IN cord-333405-ji58jbct 160 2 much much JJ cord-333405-ji58jbct 160 3 remains remain VBZ cord-333405-ji58jbct 160 4 speculative speculative JJ cord-333405-ji58jbct 160 5 about about IN cord-333405-ji58jbct 160 6 how how WRB cord-333405-ji58jbct 160 7 influenza influenza NN cord-333405-ji58jbct 160 8 viruses virus NNS cord-333405-ji58jbct 160 9 emerge emerge VBP cord-333405-ji58jbct 160 10 and and CC cord-333405-ji58jbct 160 11 spread spread VB cord-333405-ji58jbct 160 12 , , , cord-333405-ji58jbct 160 13 it -PRON- PRP cord-333405-ji58jbct 160 14 seems seem VBZ cord-333405-ji58jbct 160 15 clear clear JJ cord-333405-ji58jbct 160 16 that that IN cord-333405-ji58jbct 160 17 the the DT cord-333405-ji58jbct 160 18 process process NN cord-333405-ji58jbct 160 19 is be VBZ cord-333405-ji58jbct 160 20 driven drive VBN cord-333405-ji58jbct 160 21 by by IN cord-333405-ji58jbct 160 22 prolific prolific JJ cord-333405-ji58jbct 160 23 and and CC cord-333405-ji58jbct 160 24 complex complex JJ cord-333405-ji58jbct 160 25 viral viral JJ cord-333405-ji58jbct 160 26 evolution evolution NN cord-333405-ji58jbct 160 27 ( ( -LRB- cord-333405-ji58jbct 160 28 genetic genetic JJ cord-333405-ji58jbct 160 29 reassortment reassortment NN cord-333405-ji58jbct 160 30 and and CC cord-333405-ji58jbct 160 31 mutational mutational JJ cord-333405-ji58jbct 160 32 ' ' `` cord-333405-ji58jbct 160 33 drift drift NN cord-333405-ji58jbct 160 34 ' ' '' cord-333405-ji58jbct 160 35 ) ) -RRB- cord-333405-ji58jbct 160 36 , , , cord-333405-ji58jbct 160 37 interspecies interspecie NNS cord-333405-ji58jbct 160 38 mixing mixing NN cord-333405-ji58jbct 160 39 and and CC cord-333405-ji58jbct 160 40 adaptation adaptation NN cord-333405-ji58jbct 160 41 , , , cord-333405-ji58jbct 160 42 and and CC cord-333405-ji58jbct 160 43 ecological ecological JJ cord-333405-ji58jbct 160 44 factors factor NNS cord-333405-ji58jbct 160 45 that that WDT cord-333405-ji58jbct 160 46 bring bring VBP cord-333405-ji58jbct 160 47 humans human NNS cord-333405-ji58jbct 160 48 into into IN cord-333405-ji58jbct 160 49 contact contact NN cord-333405-ji58jbct 160 50 with with IN cord-333405-ji58jbct 160 51 animals animal NNS cord-333405-ji58jbct 160 52 and and CC cord-333405-ji58jbct 160 53 each each DT cord-333405-ji58jbct 160 54 other other JJ cord-333405-ji58jbct 160 55 . . . cord-333405-ji58jbct 161 1 By by IN cord-333405-ji58jbct 161 2 whatever whatever WDT cord-333405-ji58jbct 161 3 means mean VBZ cord-333405-ji58jbct 161 4 new new JJ cord-333405-ji58jbct 161 5 influenza influenza NN cord-333405-ji58jbct 161 6 virus virus NN cord-333405-ji58jbct 161 7 pandemic pandemic NN cord-333405-ji58jbct 161 8 strains strain NNS cord-333405-ji58jbct 161 9 emerge emerge VBP cord-333405-ji58jbct 161 10 , , , cord-333405-ji58jbct 161 11 they -PRON- PRP cord-333405-ji58jbct 161 12 eventually eventually RB cord-333405-ji58jbct 161 13 reach reach VBP cord-333405-ji58jbct 161 14 a a DT cord-333405-ji58jbct 161 15 critical critical JJ cord-333405-ji58jbct 161 16 threshold threshold NN cord-333405-ji58jbct 161 17 of of IN cord-333405-ji58jbct 161 18 human human JJ cord-333405-ji58jbct 161 19 transmission transmission NN cord-333405-ji58jbct 161 20 beyond beyond IN cord-333405-ji58jbct 161 21 which which WDT cord-333405-ji58jbct 161 22 epidemic epidemic NN cord-333405-ji58jbct 161 23 and and CC cord-333405-ji58jbct 161 24 pandemic pandemic NN cord-333405-ji58jbct 161 25 spread spread NN cord-333405-ji58jbct 161 26 follows follow VBZ cord-333405-ji58jbct 161 27 mathematically mathematically RB cord-333405-ji58jbct 161 28 predictable predictable JJ cord-333405-ji58jbct 161 29 patterns pattern NNS cord-333405-ji58jbct 161 30 . . . cord-333405-ji58jbct 162 1 The the DT cord-333405-ji58jbct 162 2 dynamics dynamic NNS cord-333405-ji58jbct 162 3 and and CC cord-333405-ji58jbct 162 4 determinants determinant NNS cord-333405-ji58jbct 162 5 of of IN cord-333405-ji58jbct 162 6 such such JJ cord-333405-ji58jbct 162 7 epidemic epidemic NN cord-333405-ji58jbct 162 8 development development NN cord-333405-ji58jbct 162 9 have have VBP cord-333405-ji58jbct 162 10 been be VBN cord-333405-ji58jbct 162 11 studied study VBN cord-333405-ji58jbct 162 12 since since IN cord-333405-ji58jbct 162 13 the the DT cord-333405-ji58jbct 162 14 nineteenth nineteenth JJ cord-333405-ji58jbct 162 15 century century NN cord-333405-ji58jbct 162 16 for for IN cord-333405-ji58jbct 162 17 several several JJ cord-333405-ji58jbct 162 18 infectious infectious JJ cord-333405-ji58jbct 162 19 diseases disease NNS cord-333405-ji58jbct 162 20 . . . cord-333405-ji58jbct 163 1 For for IN cord-333405-ji58jbct 163 2 influenza influenza NN cord-333405-ji58jbct 163 3 , , , cord-333405-ji58jbct 163 4 both both CC cord-333405-ji58jbct 163 5 historical historical JJ cord-333405-ji58jbct 163 6 and and CC cord-333405-ji58jbct 163 7 prospective prospective JJ cord-333405-ji58jbct 163 8 epidemics epidemic NNS cord-333405-ji58jbct 163 9 have have VBP cord-333405-ji58jbct 163 10 been be VBN cord-333405-ji58jbct 163 11 described describe VBN cord-333405-ji58jbct 163 12 or or CC cord-333405-ji58jbct 163 13 predicted predict VBN cord-333405-ji58jbct 163 14 using use VBG cord-333405-ji58jbct 163 15 deterministic deterministic JJ cord-333405-ji58jbct 163 16 and and CC cord-333405-ji58jbct 163 17 stochastic stochastic JJ cord-333405-ji58jbct 163 18 mathematical mathematical JJ cord-333405-ji58jbct 163 19 models model NNS cord-333405-ji58jbct 163 20 , , , cord-333405-ji58jbct 163 21 often often RB cord-333405-ji58jbct 163 22 with with IN cord-333405-ji58jbct 163 23 surprising surprising JJ cord-333405-ji58jbct 163 24 accuracy accuracy NN cord-333405-ji58jbct 163 25 when when WRB cord-333405-ji58jbct 163 26 compared compare VBN cord-333405-ji58jbct 163 27 with with IN cord-333405-ji58jbct 163 28 actual actual JJ cord-333405-ji58jbct 163 29 epidemic epidemic NN cord-333405-ji58jbct 163 30 data datum NNS cord-333405-ji58jbct 163 31 . . . cord-333405-ji58jbct 164 1 More more RBR cord-333405-ji58jbct 164 2 complicated complicated JJ cord-333405-ji58jbct 164 3 mathematical mathematical JJ cord-333405-ji58jbct 164 4 models model NNS cord-333405-ji58jbct 164 5 that that WDT cord-333405-ji58jbct 164 6 describe describe VBP cord-333405-ji58jbct 164 7 how how WRB cord-333405-ji58jbct 164 8 diseases disease NNS cord-333405-ji58jbct 164 9 spread spread VBN cord-333405-ji58jbct 164 10 by by IN cord-333405-ji58jbct 164 11 means mean NNS cord-333405-ji58jbct 164 12 other other JJ cord-333405-ji58jbct 164 13 than than IN cord-333405-ji58jbct 164 14 personto personto NN cord-333405-ji58jbct 164 15 - - HYPH cord-333405-ji58jbct 164 16 person person NN cord-333405-ji58jbct 164 17 aerosol aerosol NN cord-333405-ji58jbct 164 18 transmission transmission NN cord-333405-ji58jbct 164 19 have have VBP cord-333405-ji58jbct 164 20 generally generally RB cord-333405-ji58jbct 164 21 been be VBN cord-333405-ji58jbct 164 22 less less RBR cord-333405-ji58jbct 164 23 successful successful JJ cord-333405-ji58jbct 164 24 in in IN cord-333405-ji58jbct 164 25 describing describe VBG cord-333405-ji58jbct 164 26 and and CC cord-333405-ji58jbct 164 27 predicting predict VBG cord-333405-ji58jbct 164 28 epidemics epidemic NNS cord-333405-ji58jbct 164 29 , , , cord-333405-ji58jbct 164 30 but but CC cord-333405-ji58jbct 164 31 have have VBP cord-333405-ji58jbct 164 32 nonetheless nonetheless RB cord-333405-ji58jbct 164 33 been be VBN cord-333405-ji58jbct 164 34 helpful helpful JJ cord-333405-ji58jbct 164 35 in in IN cord-333405-ji58jbct 164 36 planning plan VBG cord-333405-ji58jbct 164 37 public public JJ cord-333405-ji58jbct 164 38 health health NN cord-333405-ji58jbct 164 39 responses response NNS cord-333405-ji58jbct 164 40 to to IN cord-333405-ji58jbct 164 41 epidemics epidemic NNS cord-333405-ji58jbct 164 42 caused cause VBN cord-333405-ji58jbct 164 43 by by IN cord-333405-ji58jbct 164 44 HIV HIV NNP cord-333405-ji58jbct 164 45 79 79 CD cord-333405-ji58jbct 164 46 , , , cord-333405-ji58jbct 164 47 vCJD vcjd JJ cord-333405-ji58jbct 164 48 80 80 CD cord-333405-ji58jbct 164 49 and and CC cord-333405-ji58jbct 164 50 other other JJ cord-333405-ji58jbct 164 51 diseases disease NNS cord-333405-ji58jbct 164 52 . . . cord-333405-ji58jbct 165 1 Mathematical mathematical JJ cord-333405-ji58jbct 165 2 modelling modelling NN cord-333405-ji58jbct 165 3 is be VBZ cord-333405-ji58jbct 165 4 also also RB cord-333405-ji58jbct 165 5 used use VBN cord-333405-ji58jbct 165 6 to to TO cord-333405-ji58jbct 165 7 determine determine VB cord-333405-ji58jbct 165 8 the the DT cord-333405-ji58jbct 165 9 impact impact NN cord-333405-ji58jbct 165 10 of of IN cord-333405-ji58jbct 165 11 emerging emerge VBG cord-333405-ji58jbct 165 12 epidemics epidemic NNS cord-333405-ji58jbct 165 13 . . . cord-333405-ji58jbct 166 1 For for IN cord-333405-ji58jbct 166 2 example example NN cord-333405-ji58jbct 166 3 , , , cord-333405-ji58jbct 166 4 it -PRON- PRP cord-333405-ji58jbct 166 5 has have VBZ cord-333405-ji58jbct 166 6 been be VBN cord-333405-ji58jbct 166 7 difficult difficult JJ cord-333405-ji58jbct 166 8 to to TO cord-333405-ji58jbct 166 9 estimate estimate VB cord-333405-ji58jbct 166 10 overall overall JJ cord-333405-ji58jbct 166 11 influenza influenza NN cord-333405-ji58jbct 166 12 mortality mortality NN cord-333405-ji58jbct 166 13 because because IN cord-333405-ji58jbct 166 14 fatal fatal JJ cord-333405-ji58jbct 166 15 infections infection NNS cord-333405-ji58jbct 166 16 are be VBP cord-333405-ji58jbct 166 17 often often RB cord-333405-ji58jbct 166 18 neither neither CC cord-333405-ji58jbct 166 19 diagnosed diagnose VBN cord-333405-ji58jbct 166 20 nor nor CC cord-333405-ji58jbct 166 21 accurately accurately RB cord-333405-ji58jbct 166 22 recorded record VBN cord-333405-ji58jbct 166 23 in in IN cord-333405-ji58jbct 166 24 hospital hospital NN cord-333405-ji58jbct 166 25 records record NNS cord-333405-ji58jbct 166 26 and and CC cord-333405-ji58jbct 166 27 death death NN cord-333405-ji58jbct 166 28 certificates certificate NNS cord-333405-ji58jbct 166 29 , , , cord-333405-ji58jbct 166 30 especially especially RB cord-333405-ji58jbct 166 31 in in IN cord-333405-ji58jbct 166 32 the the DT cord-333405-ji58jbct 166 33 elderly elderly JJ cord-333405-ji58jbct 166 34 . . . cord-333405-ji58jbct 167 1 Recent recent JJ cord-333405-ji58jbct 167 2 epidemiological epidemiological JJ cord-333405-ji58jbct 167 3 attempts attempt NNS cord-333405-ji58jbct 167 4 to to TO cord-333405-ji58jbct 167 5 obtain obtain VB cord-333405-ji58jbct 167 6 improved improve VBN cord-333405-ji58jbct 167 7 influenza influenza NN cord-333405-ji58jbct 167 8 mortality mortality NN cord-333405-ji58jbct 167 9 estimates estimate NNS cord-333405-ji58jbct 167 10 from from IN cord-333405-ji58jbct 167 11 seasonal seasonal JJ cord-333405-ji58jbct 167 12 excess excess JJ cord-333405-ji58jbct 167 13 mortality mortality NN cord-333405-ji58jbct 167 14 data datum NNS cord-333405-ji58jbct 167 15 81 81 CD cord-333405-ji58jbct 167 16 have have VBP cord-333405-ji58jbct 167 17 indicated indicate VBN cord-333405-ji58jbct 167 18 that that IN cord-333405-ji58jbct 167 19 influenza influenza NN cord-333405-ji58jbct 167 20 mortality mortality NN cord-333405-ji58jbct 167 21 may may MD cord-333405-ji58jbct 167 22 be be VB cord-333405-ji58jbct 167 23 insight insight JJ cord-333405-ji58jbct 167 24 review review NN cord-333405-ji58jbct 167 25 articles article NNS cord-333405-ji58jbct 167 26 NATURE NATURE NNP cord-333405-ji58jbct 167 27 | | HYPH cord-333405-ji58jbct 167 28 VOL VOL NNP cord-333405-ji58jbct 167 29 430 430 CD cord-333405-ji58jbct 167 30 | | NNP cord-333405-ji58jbct 167 31 8 8 CD cord-333405-ji58jbct 167 32 JULY JULY NNP cord-333405-ji58jbct 167 33 2004 2004 CD cord-333405-ji58jbct 167 34 | | SYM cord-333405-ji58jbct 167 35 www.nature.com/nature www.nature.com/nature NNP cord-333405-ji58jbct 167 36 247 247 CD cord-333405-ji58jbct 167 37 greater great JJR cord-333405-ji58jbct 167 38 than than IN cord-333405-ji58jbct 167 39 was be VBD cord-333405-ji58jbct 167 40 previously previously RB cord-333405-ji58jbct 167 41 suspected suspect VBN cord-333405-ji58jbct 167 42 , , , cord-333405-ji58jbct 167 43 because because IN cord-333405-ji58jbct 167 44 influenza influenza NN cord-333405-ji58jbct 167 45 deaths death NNS cord-333405-ji58jbct 167 46 are be VBP cord-333405-ji58jbct 167 47 frequently frequently RB cord-333405-ji58jbct 167 48 coded code VBN cord-333405-ji58jbct 167 49 under under IN cord-333405-ji58jbct 167 50 seemingly seemingly RB cord-333405-ji58jbct 167 51 unrelated unrelated JJ cord-333405-ji58jbct 167 52 categories category NNS cord-333405-ji58jbct 167 53 such such JJ cord-333405-ji58jbct 167 54 as as IN cord-333405-ji58jbct 167 55 cardiovascular cardiovascular JJ cord-333405-ji58jbct 167 56 diseases disease NNS cord-333405-ji58jbct 167 57 . . . cord-333405-ji58jbct 168 1 The the DT cord-333405-ji58jbct 168 2 same same JJ cord-333405-ji58jbct 168 3 approaches approach NNS cord-333405-ji58jbct 168 4 also also RB cord-333405-ji58jbct 168 5 show show VBP cord-333405-ji58jbct 168 6 that that IN cord-333405-ji58jbct 168 7 other other JJ cord-333405-ji58jbct 168 8 influenza influenza NN cord-333405-ji58jbct 168 9 - - HYPH cord-333405-ji58jbct 168 10 like like JJ cord-333405-ji58jbct 168 11 deaths death NNS cord-333405-ji58jbct 168 12 may may MD cord-333405-ji58jbct 168 13 actually actually RB cord-333405-ji58jbct 168 14 be be VB cord-333405-ji58jbct 168 15 due due JJ cord-333405-ji58jbct 168 16 to to IN cord-333405-ji58jbct 168 17 other other JJ cord-333405-ji58jbct 168 18 agents agent NNS cord-333405-ji58jbct 168 19 , , , cord-333405-ji58jbct 168 20 such such JJ cord-333405-ji58jbct 168 21 as as IN cord-333405-ji58jbct 168 22 respiratory respiratory JJ cord-333405-ji58jbct 168 23 syncytial syncytial JJ cord-333405-ji58jbct 168 24 virus virus NN cord-333405-ji58jbct 168 25 ( ( -LRB- cord-333405-ji58jbct 168 26 RSV RSV NNP cord-333405-ji58jbct 168 27 ) ) -RRB- cord-333405-ji58jbct 168 28 , , , cord-333405-ji58jbct 168 29 a a DT cord-333405-ji58jbct 168 30 common common JJ cord-333405-ji58jbct 168 31 childhood childhood NN cord-333405-ji58jbct 168 32 virus virus NN cord-333405-ji58jbct 168 33 that that IN cord-333405-ji58jbct 168 34 in in IN cord-333405-ji58jbct 168 35 the the DT cord-333405-ji58jbct 168 36 past past JJ cord-333405-ji58jbct 168 37 decade decade NN cord-333405-ji58jbct 168 38 has have VBZ cord-333405-ji58jbct 168 39 emerged emerge VBN cord-333405-ji58jbct 168 40 as as IN cord-333405-ji58jbct 168 41 a a DT cord-333405-ji58jbct 168 42 major major JJ cord-333405-ji58jbct 168 43 cause cause NN cord-333405-ji58jbct 168 44 of of IN cord-333405-ji58jbct 168 45 adult adult NN cord-333405-ji58jbct 168 46 mortality mortality NN cord-333405-ji58jbct 168 47 81 81 CD cord-333405-ji58jbct 168 48 . . . cord-333405-ji58jbct 169 1 Deliberately deliberately RB cord-333405-ji58jbct 169 2 emerging emerge VBG cord-333405-ji58jbct 169 3 microbes microbe NNS cord-333405-ji58jbct 169 4 are be VBP cord-333405-ji58jbct 169 5 those those DT cord-333405-ji58jbct 169 6 that that WDT cord-333405-ji58jbct 169 7 have have VBP cord-333405-ji58jbct 169 8 been be VBN cord-333405-ji58jbct 169 9 developed develop VBN cord-333405-ji58jbct 169 10 by by IN cord-333405-ji58jbct 169 11 man man NN cord-333405-ji58jbct 169 12 , , , cord-333405-ji58jbct 169 13 usually usually RB cord-333405-ji58jbct 169 14 for for IN cord-333405-ji58jbct 169 15 nefarious nefarious JJ cord-333405-ji58jbct 169 16 use use NN cord-333405-ji58jbct 169 17 . . . cord-333405-ji58jbct 170 1 The the DT cord-333405-ji58jbct 170 2 term term NN cord-333405-ji58jbct 170 3 ' ' '' cord-333405-ji58jbct 170 4 deliberately deliberately RB cord-333405-ji58jbct 170 5 emerging emerge VBG cord-333405-ji58jbct 170 6 ' ' '' cord-333405-ji58jbct 170 7 refers refer VBZ cord-333405-ji58jbct 170 8 to to IN cord-333405-ji58jbct 170 9 both both CC cord-333405-ji58jbct 170 10 naturally naturally RB cord-333405-ji58jbct 170 11 occurring occur VBG cord-333405-ji58jbct 170 12 microbial microbial JJ cord-333405-ji58jbct 170 13 agents agent NNS cord-333405-ji58jbct 170 14 such such JJ cord-333405-ji58jbct 170 15 as as IN cord-333405-ji58jbct 170 16 anthrax anthrax NN cord-333405-ji58jbct 170 17 6 6 CD cord-333405-ji58jbct 170 18 , , , cord-333405-ji58jbct 170 19 and and CC cord-333405-ji58jbct 170 20 to to IN cord-333405-ji58jbct 170 21 bioengineered bioengineere VBN cord-333405-ji58jbct 170 22 microorganisms microorganism NNS cord-333405-ji58jbct 170 23 such such JJ cord-333405-ji58jbct 170 24 as as IN cord-333405-ji58jbct 170 25 those those DT cord-333405-ji58jbct 170 26 created create VBN cord-333405-ji58jbct 170 27 by by IN cord-333405-ji58jbct 170 28 the the DT cord-333405-ji58jbct 170 29 insertion insertion NN cord-333405-ji58jbct 170 30 of of IN cord-333405-ji58jbct 170 31 genetic genetic JJ cord-333405-ji58jbct 170 32 virulence virulence NN cord-333405-ji58jbct 170 33 factors factor NNS cord-333405-ji58jbct 170 34 that that WDT cord-333405-ji58jbct 170 35 produce produce VBP cord-333405-ji58jbct 170 36 or or CC cord-333405-ji58jbct 170 37 exacerbate exacerbate VB cord-333405-ji58jbct 170 38 disease disease NN cord-333405-ji58jbct 170 39 . . . cord-333405-ji58jbct 171 1 Deliberately deliberately RB cord-333405-ji58jbct 171 2 emerging emerge VBG cord-333405-ji58jbct 171 3 microbes microbe NNS cord-333405-ji58jbct 171 4 include include VBP cord-333405-ji58jbct 171 5 microorganisms microorganism NNS cord-333405-ji58jbct 171 6 or or CC cord-333405-ji58jbct 171 7 toxins toxin NNS cord-333405-ji58jbct 171 8 produced produce VBN cord-333405-ji58jbct 171 9 in in IN cord-333405-ji58jbct 171 10 a a DT cord-333405-ji58jbct 171 11 form form NN cord-333405-ji58jbct 171 12 that that WDT cord-333405-ji58jbct 171 13 would would MD cord-333405-ji58jbct 171 14 cause cause VB cord-333405-ji58jbct 171 15 maximal maximal JJ cord-333405-ji58jbct 171 16 harm harm NN cord-333405-ji58jbct 171 17 because because IN cord-333405-ji58jbct 171 18 of of IN cord-333405-ji58jbct 171 19 ease ease NN cord-333405-ji58jbct 171 20 of of IN cord-333405-ji58jbct 171 21 dissemination dissemination NN cord-333405-ji58jbct 171 22 , , , cord-333405-ji58jbct 171 23 enhanced enhanced JJ cord-333405-ji58jbct 171 24 infectivity infectivity NN cord-333405-ji58jbct 171 25 or or CC cord-333405-ji58jbct 171 26 heightened heighten VBN cord-333405-ji58jbct 171 27 pathogenicity pathogenicity NN cord-333405-ji58jbct 171 28 82 82 CD cord-333405-ji58jbct 171 29 . . . cord-333405-ji58jbct 172 1 As as IN cord-333405-ji58jbct 172 2 concepts concept NNS cord-333405-ji58jbct 172 3 , , , cord-333405-ji58jbct 172 4 bioterrorism bioterrorism NN cord-333405-ji58jbct 172 5 and and CC cord-333405-ji58jbct 172 6 biowarfare biowarfare NN cord-333405-ji58jbct 172 7 are be VBP cord-333405-ji58jbct 172 8 probably probably RB cord-333405-ji58jbct 172 9 not not RB cord-333405-ji58jbct 172 10 new new JJ cord-333405-ji58jbct 172 11 . . . cord-333405-ji58jbct 173 1 The the DT cord-333405-ji58jbct 173 2 alleged alleged JJ cord-333405-ji58jbct 173 3 catapulting catapulting NN cord-333405-ji58jbct 173 4 of of IN cord-333405-ji58jbct 173 5 plague plague NN cord-333405-ji58jbct 173 6 - - HYPH cord-333405-ji58jbct 173 7 ridden ride VBN cord-333405-ji58jbct 173 8 corpses corpse NNS cord-333405-ji58jbct 173 9 over over IN cord-333405-ji58jbct 173 10 enemy enemy NN cord-333405-ji58jbct 173 11 walls wall NNS cord-333405-ji58jbct 173 12 in in IN cord-333405-ji58jbct 173 13 the the DT cord-333405-ji58jbct 173 14 1346 1346 CD cord-333405-ji58jbct 173 15 siege siege NN cord-333405-ji58jbct 173 16 of of IN cord-333405-ji58jbct 173 17 Caffa Caffa NNP cord-333405-ji58jbct 173 18 ( ( -LRB- cord-333405-ji58jbct 173 19 the the DT cord-333405-ji58jbct 173 20 modern modern JJ cord-333405-ji58jbct 173 21 Crimean crimean JJ cord-333405-ji58jbct 173 22 port port NN cord-333405-ji58jbct 173 23 of of IN cord-333405-ji58jbct 173 24 Feodosia Feodosia NNP cord-333405-ji58jbct 173 25 , , , cord-333405-ji58jbct 173 26 Ukraine Ukraine NNP cord-333405-ji58jbct 173 27 ) ) -RRB- cord-333405-ji58jbct 173 28 and and CC cord-333405-ji58jbct 173 29 the the DT cord-333405-ji58jbct 173 30 dispatch dispatch NN cord-333405-ji58jbct 173 31 of of IN cord-333405-ji58jbct 173 32 smallpox smallpox NN cord-333405-ji58jbct 173 33 - - HYPH cord-333405-ji58jbct 173 34 impregnated impregnate VBN cord-333405-ji58jbct 173 35 blankets blanket NNS cord-333405-ji58jbct 173 36 to to IN cord-333405-ji58jbct 173 37 Indians Indians NNPS cord-333405-ji58jbct 173 38 by by IN cord-333405-ji58jbct 173 39 British british JJ cord-333405-ji58jbct 173 40 officers officer NNS cord-333405-ji58jbct 173 41 in in IN cord-333405-ji58jbct 173 42 the the DT cord-333405-ji58jbct 173 43 Seven Seven NNP cord-333405-ji58jbct 173 44 Years Years NNPS cord-333405-ji58jbct 173 45 War War NNP cord-333405-ji58jbct 173 46 ( ( -LRB- cord-333405-ji58jbct 173 47 1754 1754 CD cord-333405-ji58jbct 173 48 - - SYM cord-333405-ji58jbct 173 49 1763 1763 CD cord-333405-ji58jbct 173 50 ) ) -RRB- cord-333405-ji58jbct 173 51 have have VBP cord-333405-ji58jbct 173 52 frequently frequently RB cord-333405-ji58jbct 173 53 been be VBN cord-333405-ji58jbct 173 54 cited cite VBN cord-333405-ji58jbct 173 55 as as IN cord-333405-ji58jbct 173 56 examples example NNS cord-333405-ji58jbct 173 57 of of IN cord-333405-ji58jbct 173 58 bioterrorism bioterrorism NN cord-333405-ji58jbct 173 59 or or CC cord-333405-ji58jbct 173 60 biowarfare biowarfare JJ cord-333405-ji58jbct 173 61 83 83 CD cord-333405-ji58jbct 173 62 , , , cord-333405-ji58jbct 173 63 84 84 CD cord-333405-ji58jbct 173 64 . . . cord-333405-ji58jbct 174 1 Two two CD cord-333405-ji58jbct 174 2 modern modern JJ cord-333405-ji58jbct 174 3 attacks attack NNS cord-333405-ji58jbct 174 4 have have VBP cord-333405-ji58jbct 174 5 been be VBN cord-333405-ji58jbct 174 6 well well RB cord-333405-ji58jbct 174 7 documented document VBN cord-333405-ji58jbct 174 8 . . . cord-333405-ji58jbct 175 1 In in IN cord-333405-ji58jbct 175 2 1984 1984 CD cord-333405-ji58jbct 175 3 , , , cord-333405-ji58jbct 175 4 an an DT cord-333405-ji58jbct 175 5 Oregon Oregon NNP cord-333405-ji58jbct 175 6 religious religious JJ cord-333405-ji58jbct 175 7 cult cult NN cord-333405-ji58jbct 175 8 spiked spike VBN cord-333405-ji58jbct 175 9 restaurant restaurant NN cord-333405-ji58jbct 175 10 salad salad NN cord-333405-ji58jbct 175 11 bars bar NNS cord-333405-ji58jbct 175 12 with with IN cord-333405-ji58jbct 175 13 Salmonellae Salmonellae NNP cord-333405-ji58jbct 175 14 in in IN cord-333405-ji58jbct 175 15 an an DT cord-333405-ji58jbct 175 16 attempt attempt NN cord-333405-ji58jbct 175 17 to to TO cord-333405-ji58jbct 175 18 sway sway VB cord-333405-ji58jbct 175 19 a a DT cord-333405-ji58jbct 175 20 local local JJ cord-333405-ji58jbct 175 21 election election NN cord-333405-ji58jbct 175 22 85 85 CD cord-333405-ji58jbct 175 23 . . . cord-333405-ji58jbct 176 1 A a DT cord-333405-ji58jbct 176 2 2001 2001 CD cord-333405-ji58jbct 176 3 anthrax anthrax NN cord-333405-ji58jbct 176 4 attack attack NN cord-333405-ji58jbct 176 5 6 6 CD cord-333405-ji58jbct 176 6 , , , cord-333405-ji58jbct 176 7 in in IN cord-333405-ji58jbct 176 8 which which WDT cord-333405-ji58jbct 176 9 a a DT cord-333405-ji58jbct 176 10 terrorist terrorist NN cord-333405-ji58jbct 176 11 mailed mail VBD cord-333405-ji58jbct 176 12 anthrax anthrax NN cord-333405-ji58jbct 176 13 - - HYPH cord-333405-ji58jbct 176 14 spore spore NN cord-333405-ji58jbct 176 15 - - HYPH cord-333405-ji58jbct 176 16 filled fill VBN cord-333405-ji58jbct 176 17 letters letter NNS cord-333405-ji58jbct 176 18 to to IN cord-333405-ji58jbct 176 19 prominent prominent JJ cord-333405-ji58jbct 176 20 figures figure NNS cord-333405-ji58jbct 176 21 , , , cord-333405-ji58jbct 176 22 including include VBG cord-333405-ji58jbct 176 23 two two CD cord-333405-ji58jbct 176 24 US US NNP cord-333405-ji58jbct 176 25 senators senator NNS cord-333405-ji58jbct 176 26 , , , cord-333405-ji58jbct 176 27 resulted result VBD cord-333405-ji58jbct 176 28 in in IN cord-333405-ji58jbct 176 29 illness illness NN cord-333405-ji58jbct 176 30 in in IN cord-333405-ji58jbct 176 31 at at RB cord-333405-ji58jbct 176 32 least least JJS cord-333405-ji58jbct 176 33 18 18 CD cord-333405-ji58jbct 176 34 people people NNS cord-333405-ji58jbct 176 35 and and CC cord-333405-ji58jbct 176 36 the the DT cord-333405-ji58jbct 176 37 death death NN cord-333405-ji58jbct 176 38 of of IN cord-333405-ji58jbct 176 39 five five CD cord-333405-ji58jbct 176 40 of of IN cord-333405-ji58jbct 176 41 these these DT cord-333405-ji58jbct 176 42 individuals individual NNS cord-333405-ji58jbct 176 43 . . . cord-333405-ji58jbct 177 1 Public public JJ cord-333405-ji58jbct 177 2 alarm alarm NN cord-333405-ji58jbct 177 3 was be VBD cord-333405-ji58jbct 177 4 elevated elevate VBN cord-333405-ji58jbct 177 5 by by IN cord-333405-ji58jbct 177 6 the the DT cord-333405-ji58jbct 177 7 knowledge knowledge NN cord-333405-ji58jbct 177 8 that that WDT cord-333405-ji58jbct 177 9 Bacillus Bacillus NNP cord-333405-ji58jbct 177 10 anthracis anthracis NN cord-333405-ji58jbct 177 11 is be VBZ cord-333405-ji58jbct 177 12 a a DT cord-333405-ji58jbct 177 13 common common JJ cord-333405-ji58jbct 177 14 and and CC cord-333405-ji58jbct 177 15 easily easily RB cord-333405-ji58jbct 177 16 obtainable obtainable JJ cord-333405-ji58jbct 177 17 enzootic enzootic JJ cord-333405-ji58jbct 177 18 and and CC cord-333405-ji58jbct 177 19 soil soil NN cord-333405-ji58jbct 177 20 organism organism NN cord-333405-ji58jbct 177 21 found find VBN cord-333405-ji58jbct 177 22 in in IN cord-333405-ji58jbct 177 23 laboratories laboratory NNS cord-333405-ji58jbct 177 24 worldwide worldwide RB cord-333405-ji58jbct 177 25 , , , cord-333405-ji58jbct 177 26 and and CC cord-333405-ji58jbct 177 27 that that IN cord-333405-ji58jbct 177 28 scientific scientific JJ cord-333405-ji58jbct 177 29 technology technology NN cord-333405-ji58jbct 177 30 had have VBD cord-333405-ji58jbct 177 31 increased increase VBN cord-333405-ji58jbct 177 32 its -PRON- PRP$ cord-333405-ji58jbct 177 33 lethality lethality NN cord-333405-ji58jbct 177 34 : : : cord-333405-ji58jbct 177 35 the the DT cord-333405-ji58jbct 177 36 spores spore NNS cord-333405-ji58jbct 177 37 had have VBD cord-333405-ji58jbct 177 38 been be VBN cord-333405-ji58jbct 177 39 weaponized weaponize VBN cord-333405-ji58jbct 177 40 by by IN cord-333405-ji58jbct 177 41 being be VBG cord-333405-ji58jbct 177 42 concentrated concentrate VBN cord-333405-ji58jbct 177 43 , , , cord-333405-ji58jbct 177 44 finely finely RB cord-333405-ji58jbct 177 45 milled mill VBN cord-333405-ji58jbct 177 46 and and CC cord-333405-ji58jbct 177 47 packed pack VBN cord-333405-ji58jbct 177 48 with with IN cord-333405-ji58jbct 177 49 a a DT cord-333405-ji58jbct 177 50 dispersal dispersal NN cord-333405-ji58jbct 177 51 agent agent NN cord-333405-ji58jbct 177 52 to to TO cord-333405-ji58jbct 177 53 increase increase VB cord-333405-ji58jbct 177 54 their -PRON- PRP$ cord-333405-ji58jbct 177 55 capacity capacity NN cord-333405-ji58jbct 177 56 to to TO cord-333405-ji58jbct 177 57 disseminate disseminate VB cord-333405-ji58jbct 177 58 82 82 CD cord-333405-ji58jbct 177 59 . . . cord-333405-ji58jbct 178 1 The the DT cord-333405-ji58jbct 178 2 United United NNP cord-333405-ji58jbct 178 3 States States NNP cord-333405-ji58jbct 178 4 , , , cord-333405-ji58jbct 178 5 the the DT cord-333405-ji58jbct 178 6 United United NNP cord-333405-ji58jbct 178 7 Kingdom Kingdom NNP cord-333405-ji58jbct 178 8 , , , cord-333405-ji58jbct 178 9 the the DT cord-333405-ji58jbct 178 10 Soviet Soviet NNP cord-333405-ji58jbct 178 11 Union Union NNP cord-333405-ji58jbct 178 12 and and CC cord-333405-ji58jbct 178 13 other other JJ cord-333405-ji58jbct 178 14 nations nation NNS cord-333405-ji58jbct 178 15 once once RB cord-333405-ji58jbct 178 16 had have VBD cord-333405-ji58jbct 178 17 sophisticated sophisticated JJ cord-333405-ji58jbct 178 18 offensive offensive JJ cord-333405-ji58jbct 178 19 bioweapons bioweapon NNS cord-333405-ji58jbct 178 20 programmes programme NNS cord-333405-ji58jbct 178 21 that that WDT cord-333405-ji58jbct 178 22 included include VBD cord-333405-ji58jbct 178 23 the the DT cord-333405-ji58jbct 178 24 production production NN cord-333405-ji58jbct 178 25 of of IN cord-333405-ji58jbct 178 26 weaponized weaponize VBN cord-333405-ji58jbct 178 27 anthrax anthrax NN cord-333405-ji58jbct 178 28 spores spore NNS cord-333405-ji58jbct 178 29 82 82 CD cord-333405-ji58jbct 178 30 . . . cord-333405-ji58jbct 179 1 Soviet soviet JJ cord-333405-ji58jbct 179 2 scientists scientist NNS cord-333405-ji58jbct 179 3 continued continue VBD cord-333405-ji58jbct 179 4 to to TO cord-333405-ji58jbct 179 5 produce produce VB cord-333405-ji58jbct 179 6 large large JJ cord-333405-ji58jbct 179 7 quantities quantity NNS cord-333405-ji58jbct 179 8 of of IN cord-333405-ji58jbct 179 9 organisms organism NNS cord-333405-ji58jbct 179 10 adapted adapt VBN cord-333405-ji58jbct 179 11 for for IN cord-333405-ji58jbct 179 12 biowarfare biowarfare NN cord-333405-ji58jbct 179 13 and and CC cord-333405-ji58jbct 179 14 bioterror bioterror NN cord-333405-ji58jbct 179 15 -among -among : cord-333405-ji58jbct 179 16 them -PRON- PRP cord-333405-ji58jbct 179 17 the the DT cord-333405-ji58jbct 179 18 agents agent NNS cord-333405-ji58jbct 179 19 of of IN cord-333405-ji58jbct 179 20 smallpox smallpox NN cord-333405-ji58jbct 179 21 , , , cord-333405-ji58jbct 179 22 plague plague NN cord-333405-ji58jbct 179 23 , , , cord-333405-ji58jbct 179 24 tularaemia tularaemia NN cord-333405-ji58jbct 179 25 and and CC cord-333405-ji58jbct 179 26 Marburg Marburg NNP cord-333405-ji58jbct 179 27 virus virus NN cord-333405-ji58jbct 179 28 -for -for : cord-333405-ji58jbct 179 29 several several JJ cord-333405-ji58jbct 179 30 years year NNS cord-333405-ji58jbct 179 31 after after IN cord-333405-ji58jbct 179 32 their -PRON- PRP$ cord-333405-ji58jbct 179 33 signing signing NN cord-333405-ji58jbct 179 34 of of IN cord-333405-ji58jbct 179 35 the the DT cord-333405-ji58jbct 179 36 Bioweapons Bioweapons NNPS cord-333405-ji58jbct 179 37 and and CC cord-333405-ji58jbct 179 38 Toxins Toxins NNP cord-333405-ji58jbct 179 39 Treaty Treaty NNP cord-333405-ji58jbct 179 40 Convention Convention NNP cord-333405-ji58jbct 179 41 in in IN cord-333405-ji58jbct 179 42 1972 1972 CD cord-333405-ji58jbct 179 43 , , , cord-333405-ji58jbct 179 44 which which WDT cord-333405-ji58jbct 179 45 forbade forbid VBD cord-333405-ji58jbct 179 46 such such JJ cord-333405-ji58jbct 179 47 activities activity NNS cord-333405-ji58jbct 179 48 82 82 CD cord-333405-ji58jbct 179 49 . . . cord-333405-ji58jbct 180 1 By by IN cord-333405-ji58jbct 180 2 1987 1987 CD cord-333405-ji58jbct 180 3 , , , cord-333405-ji58jbct 180 4 the the DT cord-333405-ji58jbct 180 5 Soviet soviet JJ cord-333405-ji58jbct 180 6 programme programme NN cord-333405-ji58jbct 180 7 was be VBD cord-333405-ji58jbct 180 8 annually annually RB cord-333405-ji58jbct 180 9 producing produce VBG cord-333405-ji58jbct 180 10 5,000 5,000 CD cord-333405-ji58jbct 180 11 tonnes tonne NNS cord-333405-ji58jbct 180 12 of of IN cord-333405-ji58jbct 180 13 weaponized weaponize VBN cord-333405-ji58jbct 180 14 anthrax anthrax NN cord-333405-ji58jbct 180 15 spores spore NNS cord-333405-ji58jbct 180 16 , , , cord-333405-ji58jbct 180 17 packing pack VBG cord-333405-ji58jbct 180 18 them -PRON- PRP cord-333405-ji58jbct 180 19 into into IN cord-333405-ji58jbct 180 20 warheads warhead NNS cord-333405-ji58jbct 180 21 and and CC cord-333405-ji58jbct 180 22 other other JJ cord-333405-ji58jbct 180 23 delivery delivery NN cord-333405-ji58jbct 180 24 devices device NNS cord-333405-ji58jbct 180 25 82 82 CD cord-333405-ji58jbct 180 26 . . . cord-333405-ji58jbct 181 1 Before before IN cord-333405-ji58jbct 181 2 the the DT cord-333405-ji58jbct 181 3 2001 2001 CD cord-333405-ji58jbct 181 4 anthrax anthrax NN cord-333405-ji58jbct 181 5 attacks attack NNS cord-333405-ji58jbct 181 6 6 6 CD cord-333405-ji58jbct 181 7 , , , cord-333405-ji58jbct 181 8 the the DT cord-333405-ji58jbct 181 9 US US NNP cord-333405-ji58jbct 181 10 scientific scientific JJ cord-333405-ji58jbct 181 11 community community NN cord-333405-ji58jbct 181 12 had have VBD cord-333405-ji58jbct 181 13 for for IN cord-333405-ji58jbct 181 14 several several JJ cord-333405-ji58jbct 181 15 years year NNS cord-333405-ji58jbct 181 16 been be VBN cord-333405-ji58jbct 181 17 bolstering bolster VBG cord-333405-ji58jbct 181 18 its -PRON- PRP$ cord-333405-ji58jbct 181 19 biodefence biodefence NN cord-333405-ji58jbct 181 20 research research NN cord-333405-ji58jbct 181 21 capacity capacity NN cord-333405-ji58jbct 181 22 . . . cord-333405-ji58jbct 182 1 The the DT cord-333405-ji58jbct 182 2 anthrax anthrax NN cord-333405-ji58jbct 182 3 attacks attack NNS cord-333405-ji58jbct 182 4 greatly greatly RB cord-333405-ji58jbct 182 5 accelerated accelerate VBD cord-333405-ji58jbct 182 6 this this DT cord-333405-ji58jbct 182 7 expansion expansion NN cord-333405-ji58jbct 182 8 as as IN cord-333405-ji58jbct 182 9 part part NN cord-333405-ji58jbct 182 10 of of IN cord-333405-ji58jbct 182 11 a a DT cord-333405-ji58jbct 182 12 national national JJ cord-333405-ji58jbct 182 13 defence defence NN cord-333405-ji58jbct 182 14 plan plan NN cord-333405-ji58jbct 182 15 , , , cord-333405-ji58jbct 182 16 which which WDT cord-333405-ji58jbct 182 17 includes include VBZ cord-333405-ji58jbct 182 18 efforts effort NNS cord-333405-ji58jbct 182 19 to to TO cord-333405-ji58jbct 182 20 provide provide VB cord-333405-ji58jbct 182 21 a a DT cord-333405-ji58jbct 182 22 knowledge knowledge NN cord-333405-ji58jbct 182 23 base base NN cord-333405-ji58jbct 182 24 for for IN cord-333405-ji58jbct 182 25 the the DT cord-333405-ji58jbct 182 26 development development NN cord-333405-ji58jbct 182 27 of of IN cord-333405-ji58jbct 182 28 effective effective JJ cord-333405-ji58jbct 182 29 countermeasures countermeasure NNS cord-333405-ji58jbct 182 30 against against IN cord-333405-ji58jbct 182 31 agents agent NNS cord-333405-ji58jbct 182 32 of of IN cord-333405-ji58jbct 182 33 bioterror bioterror NN cord-333405-ji58jbct 182 34 , , , cord-333405-ji58jbct 182 35 such such JJ cord-333405-ji58jbct 182 36 as as IN cord-333405-ji58jbct 182 37 diagnostics diagnostic NNS cord-333405-ji58jbct 182 38 , , , cord-333405-ji58jbct 182 39 therapeutics therapeutic NNS cord-333405-ji58jbct 182 40 and and CC cord-333405-ji58jbct 182 41 vaccines vaccine NNS cord-333405-ji58jbct 182 42 , , , cord-333405-ji58jbct 182 43 and and CC cord-333405-ji58jbct 182 44 to to TO cord-333405-ji58jbct 182 45 translate translate VB cord-333405-ji58jbct 182 46 this this DT cord-333405-ji58jbct 182 47 knowledge knowledge NN cord-333405-ji58jbct 182 48 into into IN cord-333405-ji58jbct 182 49 the the DT cord-333405-ji58jbct 182 50 production production NN cord-333405-ji58jbct 182 51 and and CC cord-333405-ji58jbct 182 52 delivery delivery NN cord-333405-ji58jbct 182 53 of of IN cord-333405-ji58jbct 182 54 such such JJ cord-333405-ji58jbct 182 55 measures measure NNS cord-333405-ji58jbct 182 56 86 86 CD cord-333405-ji58jbct 182 57 . . . cord-333405-ji58jbct 183 1 Bioterror Bioterror NNP cord-333405-ji58jbct 183 2 agents agent NNS cord-333405-ji58jbct 183 3 have have VBP cord-333405-ji58jbct 183 4 been be VBN cord-333405-ji58jbct 183 5 grouped group VBN cord-333405-ji58jbct 183 6 into into IN cord-333405-ji58jbct 183 7 three three CD cord-333405-ji58jbct 183 8 categories category NNS cord-333405-ji58jbct 183 9 of of IN cord-333405-ji58jbct 183 10 risk risk NN cord-333405-ji58jbct 183 11 87 87 CD cord-333405-ji58jbct 183 12 . . . cord-333405-ji58jbct 184 1 The the DT cord-333405-ji58jbct 184 2 six six CD cord-333405-ji58jbct 184 3 category category NN cord-333405-ji58jbct 184 4 A a DT cord-333405-ji58jbct 184 5 agents agent NNS cord-333405-ji58jbct 184 6 ( ( -LRB- cord-333405-ji58jbct 184 7 anthrax anthrax NN cord-333405-ji58jbct 184 8 , , , cord-333405-ji58jbct 184 9 smallpox smallpox NN cord-333405-ji58jbct 184 10 , , , cord-333405-ji58jbct 184 11 plague plague NN cord-333405-ji58jbct 184 12 , , , cord-333405-ji58jbct 184 13 tularaemia tularaemia NN cord-333405-ji58jbct 184 14 , , , cord-333405-ji58jbct 184 15 viral viral JJ cord-333405-ji58jbct 184 16 haemorrhagic haemorrhagic JJ cord-333405-ji58jbct 184 17 fevers fever NNS cord-333405-ji58jbct 184 18 and and CC cord-333405-ji58jbct 184 19 clostridial clostridial JJ cord-333405-ji58jbct 184 20 botulinum botulinum NN cord-333405-ji58jbct 184 21 toxin toxin NN cord-333405-ji58jbct 184 22 ) ) -RRB- cord-333405-ji58jbct 184 23 are be VBP cord-333405-ji58jbct 184 24 given give VBN cord-333405-ji58jbct 184 25 top top JJ cord-333405-ji58jbct 184 26 priority priority NN cord-333405-ji58jbct 184 27 because because IN cord-333405-ji58jbct 184 28 they -PRON- PRP cord-333405-ji58jbct 184 29 are be VBP cord-333405-ji58jbct 184 30 highly highly RB cord-333405-ji58jbct 184 31 lethal lethal JJ cord-333405-ji58jbct 184 32 and and CC cord-333405-ji58jbct 184 33 readily readily RB cord-333405-ji58jbct 184 34 deployed deploy VBN cord-333405-ji58jbct 184 35 as as IN cord-333405-ji58jbct 184 36 weapons weapon NNS cord-333405-ji58jbct 184 37 . . . cord-333405-ji58jbct 185 1 Category category NN cord-333405-ji58jbct 185 2 B b NN cord-333405-ji58jbct 185 3 and and CC cord-333405-ji58jbct 185 4 C c NN cord-333405-ji58jbct 185 5 agents agent NNS cord-333405-ji58jbct 185 6 include include VBP cord-333405-ji58jbct 185 7 food food NN cord-333405-ji58jbct 185 8 - - HYPH cord-333405-ji58jbct 185 9 borne bear VBN cord-333405-ji58jbct 185 10 and and CC cord-333405-ji58jbct 185 11 water water NN cord-333405-ji58jbct 185 12 - - HYPH cord-333405-ji58jbct 185 13 borne bear VBN cord-333405-ji58jbct 185 14 organisms organism NNS cord-333405-ji58jbct 185 15 that that WDT cord-333405-ji58jbct 185 16 incapacitate incapacitate VBP cord-333405-ji58jbct 185 17 but but CC cord-333405-ji58jbct 185 18 usually usually RB cord-333405-ji58jbct 185 19 do do VBP cord-333405-ji58jbct 185 20 not not RB cord-333405-ji58jbct 185 21 kill kill VB cord-333405-ji58jbct 185 22 . . . cord-333405-ji58jbct 186 1 Infectious infectious JJ cord-333405-ji58jbct 186 2 diseases disease NNS cord-333405-ji58jbct 186 3 will will MD cord-333405-ji58jbct 186 4 continue continue VB cord-333405-ji58jbct 186 5 to to TO cord-333405-ji58jbct 186 6 emerge emerge VB cord-333405-ji58jbct 186 7 and and CC cord-333405-ji58jbct 186 8 re re VB cord-333405-ji58jbct 186 9 - - NN cord-333405-ji58jbct 186 10 emerge emerge VB cord-333405-ji58jbct 186 11 , , , cord-333405-ji58jbct 186 12 leading lead VBG cord-333405-ji58jbct 186 13 to to IN cord-333405-ji58jbct 186 14 unpredictable unpredictable JJ cord-333405-ji58jbct 186 15 epidemics epidemic NNS cord-333405-ji58jbct 186 16 and and CC cord-333405-ji58jbct 186 17 difficult difficult JJ cord-333405-ji58jbct 186 18 challenges challenge NNS cord-333405-ji58jbct 186 19 to to IN cord-333405-ji58jbct 186 20 public public JJ cord-333405-ji58jbct 186 21 health health NN cord-333405-ji58jbct 186 22 and and CC cord-333405-ji58jbct 186 23 to to IN cord-333405-ji58jbct 186 24 microbiology microbiology NN cord-333405-ji58jbct 186 25 and and CC cord-333405-ji58jbct 186 26 allied allied NNP cord-333405-ji58jbct 186 27 sciences science NNS cord-333405-ji58jbct 186 28 . . . cord-333405-ji58jbct 187 1 Surveillance surveillance NN cord-333405-ji58jbct 187 2 and and CC cord-333405-ji58jbct 187 3 response response NN cord-333405-ji58jbct 187 4 , , , cord-333405-ji58jbct 187 5 the the DT cord-333405-ji58jbct 187 6 key key JJ cord-333405-ji58jbct 187 7 elements element NNS cord-333405-ji58jbct 187 8 in in IN cord-333405-ji58jbct 187 9 controlling control VBG cord-333405-ji58jbct 187 10 EIs EIs NNP cord-333405-ji58jbct 187 11 , , , cord-333405-ji58jbct 187 12 be be VB cord-333405-ji58jbct 187 13 they -PRON- PRP cord-333405-ji58jbct 187 14 naturally naturally RB cord-333405-ji58jbct 187 15 occurring occur VBG cord-333405-ji58jbct 187 16 or or CC cord-333405-ji58jbct 187 17 deliberately deliberately RB cord-333405-ji58jbct 187 18 engineered engineer VBN cord-333405-ji58jbct 187 19 , , , cord-333405-ji58jbct 187 20 depend depend VB cord-333405-ji58jbct 187 21 on on IN cord-333405-ji58jbct 187 22 rapid rapid JJ cord-333405-ji58jbct 187 23 clinical clinical JJ cord-333405-ji58jbct 187 24 diagnosis diagnosis NN cord-333405-ji58jbct 187 25 and and CC cord-333405-ji58jbct 187 26 detection detection NN cord-333405-ji58jbct 187 27 and and CC cord-333405-ji58jbct 187 28 containment containment NN cord-333405-ji58jbct 187 29 in in IN cord-333405-ji58jbct 187 30 populations population NNS cord-333405-ji58jbct 187 31 and and CC cord-333405-ji58jbct 187 32 89 89 CD cord-333405-ji58jbct 187 33 , , , cord-333405-ji58jbct 187 34 which which WDT cord-333405-ji58jbct 187 35 along along IN cord-333405-ji58jbct 187 36 with with IN cord-333405-ji58jbct 187 37 state state NN cord-333405-ji58jbct 187 38 and and CC cord-333405-ji58jbct 187 39 local local JJ cord-333405-ji58jbct 187 40 health health NN cord-333405-ji58jbct 187 41 departments department NNS cord-333405-ji58jbct 187 42 and and CC cord-333405-ji58jbct 187 43 other other JJ cord-333405-ji58jbct 187 44 agencies agency NNS cord-333405-ji58jbct 187 45 have have VBP cord-333405-ji58jbct 187 46 been be VBN cord-333405-ji58jbct 187 47 making make VBG cord-333405-ji58jbct 187 48 significant significant JJ cord-333405-ji58jbct 187 49 strides stride NNS cord-333405-ji58jbct 187 50 in in IN cord-333405-ji58jbct 187 51 national national JJ cord-333405-ji58jbct 187 52 surveillance surveillance NN cord-333405-ji58jbct 187 53 - - HYPH cord-333405-ji58jbct 187 54 response response NN cord-333405-ji58jbct 187 55 capacity capacity NN cord-333405-ji58jbct 187 56 . . . cord-333405-ji58jbct 188 1 The the DT cord-333405-ji58jbct 188 2 enormous enormous JJ cord-333405-ji58jbct 188 3 influx influx NN cord-333405-ji58jbct 188 4 of of IN cord-333405-ji58jbct 188 5 US US NNP cord-333405-ji58jbct 188 6 government government NN cord-333405-ji58jbct 188 7 - - HYPH cord-333405-ji58jbct 188 8 funded fund VBN cord-333405-ji58jbct 188 9 research research NN cord-333405-ji58jbct 188 10 resources resource NNS cord-333405-ji58jbct 188 11 ( ( -LRB- cord-333405-ji58jbct 188 12 largely largely RB cord-333405-ji58jbct 188 13 through through IN cord-333405-ji58jbct 188 14 the the DT cord-333405-ji58jbct 188 15 National National NNP cord-333405-ji58jbct 188 16 Institutes Institutes NNPS cord-333405-ji58jbct 188 17 of of IN cord-333405-ji58jbct 188 18 Health Health NNP cord-333405-ji58jbct 188 19 ) ) -RRB- cord-333405-ji58jbct 188 20 and and CC cord-333405-ji58jbct 188 21 public public JJ cord-333405-ji58jbct 188 22 health health NN cord-333405-ji58jbct 188 23 resources resource NNS cord-333405-ji58jbct 188 24 ( ( -LRB- cord-333405-ji58jbct 188 25 mainly mainly RB cord-333405-ji58jbct 188 26 through through IN cord-333405-ji58jbct 188 27 the the DT cord-333405-ji58jbct 188 28 CDC CDC NNP cord-333405-ji58jbct 188 29 , , , cord-333405-ji58jbct 188 30 and and CC cord-333405-ji58jbct 188 31 state state NN cord-333405-ji58jbct 188 32 and and CC cord-333405-ji58jbct 188 33 local local JJ cord-333405-ji58jbct 188 34 public public JJ cord-333405-ji58jbct 188 35 health health NN cord-333405-ji58jbct 188 36 agencies agency NNS cord-333405-ji58jbct 188 37 ) ) -RRB- cord-333405-ji58jbct 188 38 in in IN cord-333405-ji58jbct 188 39 response response NN cord-333405-ji58jbct 188 40 to to IN cord-333405-ji58jbct 188 41 the the DT cord-333405-ji58jbct 188 42 increased increase VBN cord-333405-ji58jbct 188 43 threat threat NN cord-333405-ji58jbct 188 44 of of IN cord-333405-ji58jbct 188 45 a a DT cord-333405-ji58jbct 188 46 bioterrorist bioterrorist NN cord-333405-ji58jbct 188 47 attack attack NN cord-333405-ji58jbct 188 48 86 86 CD cord-333405-ji58jbct 188 49 will will MD cord-333405-ji58jbct 188 50 fortify fortify VB cord-333405-ji58jbct 188 51 the the DT cord-333405-ji58jbct 188 52 response response NN cord-333405-ji58jbct 188 53 capabilities capability NNS cord-333405-ji58jbct 188 54 related relate VBN cord-333405-ji58jbct 188 55 to to IN cord-333405-ji58jbct 188 56 all all DT cord-333405-ji58jbct 188 57 EIs ei NNS cord-333405-ji58jbct 188 58 . . . cord-333405-ji58jbct 189 1 However however RB cord-333405-ji58jbct 189 2 , , , cord-333405-ji58jbct 189 3 it -PRON- PRP cord-333405-ji58jbct 189 4 is be VBZ cord-333405-ji58jbct 189 5 clear clear JJ cord-333405-ji58jbct 189 6 that that IN cord-333405-ji58jbct 189 7 surveillance surveillance NN cord-333405-ji58jbct 189 8 and and CC cord-333405-ji58jbct 189 9 other other JJ cord-333405-ji58jbct 189 10 activities activity NNS cord-333405-ji58jbct 189 11 that that WDT cord-333405-ji58jbct 189 12 traditionally traditionally RB cord-333405-ji58jbct 189 13 fall fall VBP cord-333405-ji58jbct 189 14 within within IN cord-333405-ji58jbct 189 15 the the DT cord-333405-ji58jbct 189 16 domain domain NN cord-333405-ji58jbct 189 17 of of IN cord-333405-ji58jbct 189 18 public public JJ cord-333405-ji58jbct 189 19 health health NN cord-333405-ji58jbct 189 20 are be VBP cord-333405-ji58jbct 189 21 not not RB cord-333405-ji58jbct 189 22 in in IN cord-333405-ji58jbct 189 23 themselves -PRON- PRP cord-333405-ji58jbct 189 24 sufficient sufficient JJ cord-333405-ji58jbct 189 25 to to TO cord-333405-ji58jbct 189 26 adequately adequately RB cord-333405-ji58jbct 189 27 address address VB cord-333405-ji58jbct 189 28 the the DT cord-333405-ji58jbct 189 29 problem problem NN cord-333405-ji58jbct 189 30 of of IN cord-333405-ji58jbct 189 31 EIs EIs NNP cord-333405-ji58jbct 189 32 . . . cord-333405-ji58jbct 190 1 Of of IN cord-333405-ji58jbct 190 2 critical critical JJ cord-333405-ji58jbct 190 3 importance importance NN cord-333405-ji58jbct 190 4 are be VBP cord-333405-ji58jbct 190 5 basic basic JJ cord-333405-ji58jbct 190 6 , , , cord-333405-ji58jbct 190 7 translational translational JJ cord-333405-ji58jbct 190 8 and and CC cord-333405-ji58jbct 190 9 applied applied JJ cord-333405-ji58jbct 190 10 research research NN cord-333405-ji58jbct 190 11 efforts effort NNS cord-333405-ji58jbct 190 12 to to TO cord-333405-ji58jbct 190 13 develop develop VB cord-333405-ji58jbct 190 14 advanced advanced JJ cord-333405-ji58jbct 190 15 countermeasures countermeasure NNS cord-333405-ji58jbct 190 16 such such JJ cord-333405-ji58jbct 190 17 as as IN cord-333405-ji58jbct 190 18 surveillance surveillance NN cord-333405-ji58jbct 190 19 tools tool NNS cord-333405-ji58jbct 190 20 , , , cord-333405-ji58jbct 190 21 diagnostic diagnostic JJ cord-333405-ji58jbct 190 22 tests test NNS cord-333405-ji58jbct 190 23 , , , cord-333405-ji58jbct 190 24 vaccines vaccine NNS cord-333405-ji58jbct 190 25 and and CC cord-333405-ji58jbct 190 26 therapeutics therapeutic NNS cord-333405-ji58jbct 190 27 86 86 CD cord-333405-ji58jbct 190 28 . . . cord-333405-ji58jbct 191 1 Genomics genomic NNS cord-333405-ji58jbct 191 2 , , , cord-333405-ji58jbct 191 3 proteomics proteomic NNS cord-333405-ji58jbct 191 4 and and CC cord-333405-ji58jbct 191 5 advances advance NNS cord-333405-ji58jbct 191 6 in in IN cord-333405-ji58jbct 191 7 nanotechnology nanotechnology NN cord-333405-ji58jbct 191 8 90 90 CD cord-333405-ji58jbct 191 9 are be VBP cord-333405-ji58jbct 191 10 increasingly increasingly RB cord-333405-ji58jbct 191 11 being be VBG cord-333405-ji58jbct 191 12 exploited exploit VBN cord-333405-ji58jbct 191 13 in in IN cord-333405-ji58jbct 191 14 diagnostic diagnostic JJ cord-333405-ji58jbct 191 15 , , , cord-333405-ji58jbct 191 16 therapeutic therapeutic JJ cord-333405-ji58jbct 191 17 and and CC cord-333405-ji58jbct 191 18 microbial microbial JJ cord-333405-ji58jbct 191 19 research research NN cord-333405-ji58jbct 191 20 applications application NNS cord-333405-ji58jbct 191 21 , , , cord-333405-ji58jbct 191 22 and and CC cord-333405-ji58jbct 191 23 in in IN cord-333405-ji58jbct 191 24 rational rational JJ cord-333405-ji58jbct 191 25 drug drug NN cord-333405-ji58jbct 191 26 and and CC cord-333405-ji58jbct 191 27 vaccine vaccine NN cord-333405-ji58jbct 191 28 design design NN cord-333405-ji58jbct 191 29 . . . cord-333405-ji58jbct 192 1 Direct direct JJ cord-333405-ji58jbct 192 2 and and CC cord-333405-ji58jbct 192 3 computational computational JJ cord-333405-ji58jbct 192 4 structural structural JJ cord-333405-ji58jbct 192 5 determination determination NN cord-333405-ji58jbct 192 6 91 91 CD cord-333405-ji58jbct 192 7 , , , cord-333405-ji58jbct 192 8 prediction prediction NN cord-333405-ji58jbct 192 9 of of IN cord-333405-ji58jbct 192 10 protein protein NN cord-333405-ji58jbct 192 11 - - HYPH cord-333405-ji58jbct 192 12 protein protein NN cord-333405-ji58jbct 192 13 interactions interaction NNS cord-333405-ji58jbct 192 14 between between IN cord-333405-ji58jbct 192 15 microorganisms microorganism NNS cord-333405-ji58jbct 192 16 and and CC cord-333405-ji58jbct 192 17 drugs drug NNS cord-333405-ji58jbct 192 18 , , , cord-333405-ji58jbct 192 19 and and CC cord-333405-ji58jbct 192 20 sophisticated sophisticated JJ cord-333405-ji58jbct 192 21 bioinformatics bioinformatic NNS cord-333405-ji58jbct 192 22 techniques technique NNS cord-333405-ji58jbct 192 23 support support VBP cord-333405-ji58jbct 192 24 research research NN cord-333405-ji58jbct 192 25 in in IN cord-333405-ji58jbct 192 26 all all DT cord-333405-ji58jbct 192 27 of of IN cord-333405-ji58jbct 192 28 the the DT cord-333405-ji58jbct 192 29 above above JJ cord-333405-ji58jbct 192 30 areas area NNS cord-333405-ji58jbct 192 31 . . . cord-333405-ji58jbct 193 1 These these DT cord-333405-ji58jbct 193 2 technologies technology NNS cord-333405-ji58jbct 193 3 have have VBP cord-333405-ji58jbct 193 4 led lead VBN cord-333405-ji58jbct 193 5 to to IN cord-333405-ji58jbct 193 6 numerous numerous JJ cord-333405-ji58jbct 193 7 advances advance NNS cord-333405-ji58jbct 193 8 in in IN cord-333405-ji58jbct 193 9 real real JJ cord-333405-ji58jbct 193 10 - - HYPH cord-333405-ji58jbct 193 11 world world NN cord-333405-ji58jbct 193 12 utility utility NN cord-333405-ji58jbct 193 13 against against IN cord-333405-ji58jbct 193 14 EIs EIs NNP cord-333405-ji58jbct 193 15 , , , cord-333405-ji58jbct 193 16 most most RBS cord-333405-ji58jbct 193 17 notably notably RB cord-333405-ji58jbct 193 18 in in IN cord-333405-ji58jbct 193 19 the the DT cord-333405-ji58jbct 193 20 development development NN cord-333405-ji58jbct 193 21 of of IN cord-333405-ji58jbct 193 22 more more JJR cord-333405-ji58jbct 193 23 than than IN cord-333405-ji58jbct 193 24 20 20 CD cord-333405-ji58jbct 193 25 antiretroviral antiretroviral JJ cord-333405-ji58jbct 193 26 drugs drug NNS cord-333405-ji58jbct 193 27 that that WDT cord-333405-ji58jbct 193 28 can can MD cord-333405-ji58jbct 193 29 effectively effectively RB cord-333405-ji58jbct 193 30 suppress suppress VB cord-333405-ji58jbct 193 31 HIV HIV NNP cord-333405-ji58jbct 193 32 replication replication NN cord-333405-ji58jbct 193 33 . . . cord-333405-ji58jbct 194 1 Where where WRB cord-333405-ji58jbct 194 2 they -PRON- PRP cord-333405-ji58jbct 194 3 are be VBP cord-333405-ji58jbct 194 4 available available JJ cord-333405-ji58jbct 194 5 and and CC cord-333405-ji58jbct 194 6 properly properly RB cord-333405-ji58jbct 194 7 used use VBN cord-333405-ji58jbct 194 8 in in IN cord-333405-ji58jbct 194 9 HIV HIV NNP cord-333405-ji58jbct 194 10 - - HYPH cord-333405-ji58jbct 194 11 infected infect VBN cord-333405-ji58jbct 194 12 individuals individual NNS cord-333405-ji58jbct 194 13 , , , cord-333405-ji58jbct 194 14 these these DT cord-333405-ji58jbct 194 15 medications medication NNS cord-333405-ji58jbct 194 16 have have VBP cord-333405-ji58jbct 194 17 dramatically dramatically RB cord-333405-ji58jbct 194 18 reduced reduce VBN cord-333405-ji58jbct 194 19 HIV HIV NNP cord-333405-ji58jbct 194 20 morbidity morbidity NN cord-333405-ji58jbct 194 21 and and CC cord-333405-ji58jbct 194 22 mortality mortality NN cord-333405-ji58jbct 194 23 92 92 CD cord-333405-ji58jbct 194 24 . . . cord-333405-ji58jbct 195 1 Gene gene NN cord-333405-ji58jbct 195 2 - - HYPH cord-333405-ji58jbct 195 3 and and CC cord-333405-ji58jbct 195 4 protein protein NN cord-333405-ji58jbct 195 5 - - HYPH cord-333405-ji58jbct 195 6 based base VBN cord-333405-ji58jbct 195 7 microarrays microarray NNS cord-333405-ji58jbct 195 8 can can MD cord-333405-ji58jbct 195 9 be be VB cord-333405-ji58jbct 195 10 used use VBN cord-333405-ji58jbct 195 11 to to TO cord-333405-ji58jbct 195 12 detect detect VB cord-333405-ji58jbct 195 13 pathogen pathogen NN cord-333405-ji58jbct 195 14 signals signal NNS cord-333405-ji58jbct 195 15 , , , cord-333405-ji58jbct 195 16 to to TO cord-333405-ji58jbct 195 17 monitor monitor VB cord-333405-ji58jbct 195 18 resistance resistance NN cord-333405-ji58jbct 195 19 to to IN cord-333405-ji58jbct 195 20 anti anti JJ cord-333405-ji58jbct 195 21 - - JJ cord-333405-ji58jbct 195 22 infective infective JJ cord-333405-ji58jbct 195 23 agents agent NNS cord-333405-ji58jbct 195 24 , , , cord-333405-ji58jbct 195 25 to to TO cord-333405-ji58jbct 195 26 characterize characterize VB cord-333405-ji58jbct 195 27 host host NN cord-333405-ji58jbct 195 28 gene gene NN cord-333405-ji58jbct 195 29 responses response NNS cord-333405-ji58jbct 195 30 to to IN cord-333405-ji58jbct 195 31 recent recent JJ cord-333405-ji58jbct 195 32 infections infection NNS cord-333405-ji58jbct 195 33 , , , cord-333405-ji58jbct 195 34 and and CC cord-333405-ji58jbct 195 35 to to TO cord-333405-ji58jbct 195 36 facilitate facilitate VB cord-333405-ji58jbct 195 37 the the DT cord-333405-ji58jbct 195 38 development development NN cord-333405-ji58jbct 195 39 of of IN cord-333405-ji58jbct 195 40 new new JJ cord-333405-ji58jbct 195 41 drugs drug NNS cord-333405-ji58jbct 195 42 and and CC cord-333405-ji58jbct 195 43 vaccines vaccine NNS cord-333405-ji58jbct 195 44 93 93 CD cord-333405-ji58jbct 195 45 . . . cord-333405-ji58jbct 196 1 Basic basic JJ cord-333405-ji58jbct 196 2 and and CC cord-333405-ji58jbct 196 3 applied apply VBD cord-333405-ji58jbct 196 4 research research NN cord-333405-ji58jbct 196 5 together together RB cord-333405-ji58jbct 196 6 have have VBP cord-333405-ji58jbct 196 7 provided provide VBN cord-333405-ji58jbct 196 8 promising promising JJ cord-333405-ji58jbct 196 9 new new JJ cord-333405-ji58jbct 196 10 vaccine vaccine NN cord-333405-ji58jbct 196 11 platforms platform NNS cord-333405-ji58jbct 196 12 , , , cord-333405-ji58jbct 196 13 such such JJ cord-333405-ji58jbct 196 14 as as IN cord-333405-ji58jbct 196 15 recombinant recombinant JJ cord-333405-ji58jbct 196 16 proteins protein NNS cord-333405-ji58jbct 196 17 , , , cord-333405-ji58jbct 196 18 immunogenic immunogenic JJ cord-333405-ji58jbct 196 19 peptides peptide NNS cord-333405-ji58jbct 196 20 , , , cord-333405-ji58jbct 196 21 naked naked JJ cord-333405-ji58jbct 196 22 DNA dna NN cord-333405-ji58jbct 196 23 vaccines vaccine NNS cord-333405-ji58jbct 196 24 , , , cord-333405-ji58jbct 196 25 viral viral JJ cord-333405-ji58jbct 196 26 vectors vector NNS cord-333405-ji58jbct 196 27 of of IN cord-333405-ji58jbct 196 28 extraneous extraneous JJ cord-333405-ji58jbct 196 29 genes gene NNS cord-333405-ji58jbct 196 30 encoding encode VBG cord-333405-ji58jbct 196 31 immunogenic immunogenic JJ cord-333405-ji58jbct 196 32 proteins protein NNS cord-333405-ji58jbct 196 33 ( ( -LRB- cord-333405-ji58jbct 196 34 including include VBG cord-333405-ji58jbct 196 35 chimaeras chimaeras NNP cord-333405-ji58jbct 196 36 ) ) -RRB- cord-333405-ji58jbct 196 37 , , , cord-333405-ji58jbct 196 38 replicons replicon NNS cord-333405-ji58jbct 196 39 and and CC cord-333405-ji58jbct 196 40 pseudovirions pseudovirion NNS cord-333405-ji58jbct 196 41 94 94 CD cord-333405-ji58jbct 196 42 . . . cord-333405-ji58jbct 197 1 Many many JJ cord-333405-ji58jbct 197 2 novel novel JJ cord-333405-ji58jbct 197 3 vaccine vaccine NN cord-333405-ji58jbct 197 4 candidates candidate NNS cord-333405-ji58jbct 197 5 are be VBP cord-333405-ji58jbct 197 6 now now RB cord-333405-ji58jbct 197 7 being be VBG cord-333405-ji58jbct 197 8 developed develop VBN cord-333405-ji58jbct 197 9 against against IN cord-333405-ji58jbct 197 10 EIs EIs NNP cord-333405-ji58jbct 197 11 such such JJ cord-333405-ji58jbct 197 12 as as IN cord-333405-ji58jbct 197 13 HIV HIV NNP cord-333405-ji58jbct 197 14 , , , cord-333405-ji58jbct 197 15 Ebola Ebola NNP cord-333405-ji58jbct 197 16 virus virus NN cord-333405-ji58jbct 197 17 , , , cord-333405-ji58jbct 197 18 West West NNP cord-333405-ji58jbct 197 19 Nile Nile NNP cord-333405-ji58jbct 197 20 virus virus NN cord-333405-ji58jbct 197 21 , , , cord-333405-ji58jbct 197 22 dengue dengue NN cord-333405-ji58jbct 197 23 , , , cord-333405-ji58jbct 197 24 the the DT cord-333405-ji58jbct 197 25 SARS SARS NNP cord-333405-ji58jbct 197 26 coronavirus coronavirus NN cord-333405-ji58jbct 197 27 , , , cord-333405-ji58jbct 197 28 tuberculosis tuberculosis NN cord-333405-ji58jbct 197 29 and and CC cord-333405-ji58jbct 197 30 malaria malaria NN cord-333405-ji58jbct 197 31 . . . cord-333405-ji58jbct 198 1 Of of IN cord-333405-ji58jbct 198 2 particular particular JJ cord-333405-ji58jbct 198 3 note note NN cord-333405-ji58jbct 198 4 are be VBP cord-333405-ji58jbct 198 5 novel novel JJ cord-333405-ji58jbct 198 6 tuberculosis tuberculosis NN cord-333405-ji58jbct 198 7 vaccines vaccine NNS cord-333405-ji58jbct 198 8 that that WDT cord-333405-ji58jbct 198 9 recently recently RB cord-333405-ji58jbct 198 10 entered enter VBD cord-333405-ji58jbct 198 11 clinical clinical JJ cord-333405-ji58jbct 198 12 trials trial NNS cord-333405-ji58jbct 198 13 -the -the DT cord-333405-ji58jbct 198 14 first first JJ cord-333405-ji58jbct 198 15 time time NN cord-333405-ji58jbct 198 16 in in IN cord-333405-ji58jbct 198 17 more more JJR cord-333405-ji58jbct 198 18 than than IN cord-333405-ji58jbct 198 19 60 60 CD cord-333405-ji58jbct 198 20 years year NNS cord-333405-ji58jbct 198 21 that that IN cord-333405-ji58jbct 198 22 new new JJ cord-333405-ji58jbct 198 23 approaches approach NNS cord-333405-ji58jbct 198 24 to to IN cord-333405-ji58jbct 198 25 vaccination vaccination NN cord-333405-ji58jbct 198 26 for for IN cord-333405-ji58jbct 198 27 tuberculosis tuberculosis NN cord-333405-ji58jbct 198 28 have have VBP cord-333405-ji58jbct 198 29 been be VBN cord-333405-ji58jbct 198 30 assessed assess VBN cord-333405-ji58jbct 198 31 in in IN cord-333405-ji58jbct 198 32 humans human NNS cord-333405-ji58jbct 198 33 95 95 CD cord-333405-ji58jbct 198 34 . . . cord-333405-ji58jbct 199 1 Chimaeric Chimaeric NNP cord-333405-ji58jbct 199 2 flavivirus flavivirus JJ cord-333405-ji58jbct 199 3 vaccines vaccine NNS cord-333405-ji58jbct 199 4 for for IN cord-333405-ji58jbct 199 5 West West NNP cord-333405-ji58jbct 199 6 Nile Nile NNP cord-333405-ji58jbct 199 7 virus virus NN cord-333405-ji58jbct 199 8 , , , cord-333405-ji58jbct 199 9 dengue dengue NN cord-333405-ji58jbct 199 10 and and CC cord-333405-ji58jbct 199 11 Japanese japanese JJ cord-333405-ji58jbct 199 12 encephalitis encephalitis NN cord-333405-ji58jbct 199 13 virus virus NN cord-333405-ji58jbct 199 14 are be VBP cord-333405-ji58jbct 199 15 effective effective JJ cord-333405-ji58jbct 199 16 in in IN cord-333405-ji58jbct 199 17 animal animal NN cord-333405-ji58jbct 199 18 models model NNS cord-333405-ji58jbct 199 19 and and CC cord-333405-ji58jbct 199 20 are be VBP cord-333405-ji58jbct 199 21 in in IN cord-333405-ji58jbct 199 22 various various JJ cord-333405-ji58jbct 199 23 stages stage NNS cord-333405-ji58jbct 199 24 of of IN cord-333405-ji58jbct 199 25 clinical clinical JJ cord-333405-ji58jbct 199 26 testing testing NN cord-333405-ji58jbct 199 27 95 95 CD cord-333405-ji58jbct 199 28 . . . cord-333405-ji58jbct 200 1 Our -PRON- PRP$ cord-333405-ji58jbct 200 2 growing grow VBG cord-333405-ji58jbct 200 3 understanding understanding NN cord-333405-ji58jbct 200 4 of of IN cord-333405-ji58jbct 200 5 the the DT cord-333405-ji58jbct 200 6 human human JJ cord-333405-ji58jbct 200 7 immune immune JJ cord-333405-ji58jbct 200 8 system system NN cord-333405-ji58jbct 200 9 is be VBZ cord-333405-ji58jbct 200 10 also also RB cord-333405-ji58jbct 200 11 helping help VBG cord-333405-ji58jbct 200 12 to to TO cord-333405-ji58jbct 200 13 accelerate accelerate VB cord-333405-ji58jbct 200 14 vaccine vaccine NN cord-333405-ji58jbct 200 15 development development NN cord-333405-ji58jbct 200 16 . . . cord-333405-ji58jbct 201 1 This this DT cord-333405-ji58jbct 201 2 is be VBZ cord-333405-ji58jbct 201 3 especially especially RB cord-333405-ji58jbct 201 4 true true JJ cord-333405-ji58jbct 201 5 in in IN cord-333405-ji58jbct 201 6 the the DT cord-333405-ji58jbct 201 7 case case NN cord-333405-ji58jbct 201 8 of of IN cord-333405-ji58jbct 201 9 innate innate JJ cord-333405-ji58jbct 201 10 immune immune JJ cord-333405-ji58jbct 201 11 responses response NNS cord-333405-ji58jbct 201 12 , , , cord-333405-ji58jbct 201 13 which which WDT cord-333405-ji58jbct 201 14 are be VBP cord-333405-ji58jbct 201 15 evolutionarily evolutionarily RB cord-333405-ji58jbct 201 16 older old JJR cord-333405-ji58jbct 201 17 , , , cord-333405-ji58jbct 201 18 less less RBR cord-333405-ji58jbct 201 19 specific specific JJ cord-333405-ji58jbct 201 20 and and CC cord-333405-ji58jbct 201 21 faster fast RBR cord-333405-ji58jbct 201 22 - - HYPH cord-333405-ji58jbct 201 23 acting act VBG cord-333405-ji58jbct 201 24 than than IN cord-333405-ji58jbct 201 25 the the DT cord-333405-ji58jbct 201 26 adaptive adaptive JJ cord-333405-ji58jbct 201 27 responses response NNS cord-333405-ji58jbct 201 28 that that WDT cord-333405-ji58jbct 201 29 have have VBP cord-333405-ji58jbct 201 30 been be VBN cord-333405-ji58jbct 201 31 the the DT cord-333405-ji58jbct 201 32 traditional traditional JJ cord-333405-ji58jbct 201 33 targets target NNS cord-333405-ji58jbct 201 34 of of IN cord-333405-ji58jbct 201 35 vaccines vaccine NNS cord-333405-ji58jbct 201 36 96 96 CD cord-333405-ji58jbct 201 37 . . . cord-333405-ji58jbct 202 1 As as IN cord-333405-ji58jbct 202 2 we -PRON- PRP cord-333405-ji58jbct 202 3 learn learn VBP cord-333405-ji58jbct 202 4 more more RBR cord-333405-ji58jbct 202 5 about about IN cord-333405-ji58jbct 202 6 innate innate JJ cord-333405-ji58jbct 202 7 immunity immunity NN cord-333405-ji58jbct 202 8 and and CC cord-333405-ji58jbct 202 9 its -PRON- PRP$ cord-333405-ji58jbct 202 10 relationship relationship NN cord-333405-ji58jbct 202 11 with with IN cord-333405-ji58jbct 202 12 the the DT cord-333405-ji58jbct 202 13 adaptive adaptive JJ cord-333405-ji58jbct 202 14 immune immune JJ cord-333405-ji58jbct 202 15 system system NN cord-333405-ji58jbct 202 16 , , , cord-333405-ji58jbct 202 17 opportunities opportunity NNS cord-333405-ji58jbct 202 18 to to TO cord-333405-ji58jbct 202 19 create create VB cord-333405-ji58jbct 202 20 more more JJR cord-333405-ji58jbct 202 21 effective effective JJ cord-333405-ji58jbct 202 22 vaccine vaccine NN cord-333405-ji58jbct 202 23 adjuvants adjuvant NNS cord-333405-ji58jbct 202 24 will will MD cord-333405-ji58jbct 202 25 emerge emerge VB cord-333405-ji58jbct 202 26 . . . cord-333405-ji58jbct 203 1 For for IN cord-333405-ji58jbct 203 2 example example NN cord-333405-ji58jbct 203 3 , , , cord-333405-ji58jbct 203 4 synthetic synthetic JJ cord-333405-ji58jbct 203 5 DNA dna NN cord-333405-ji58jbct 203 6 sequences sequence NNS cord-333405-ji58jbct 203 7 that that WDT cord-333405-ji58jbct 203 8 contain contain VBP cord-333405-ji58jbct 203 9 repeated repeat VBN cord-333405-ji58jbct 203 10 CpG cpg NN cord-333405-ji58jbct 203 11 motifs motif NNS cord-333405-ji58jbct 203 12 mimic mimic VBP cord-333405-ji58jbct 203 13 the the DT cord-333405-ji58jbct 203 14 stimulatory stimulatory JJ cord-333405-ji58jbct 203 15 activity activity NN cord-333405-ji58jbct 203 16 that that WDT cord-333405-ji58jbct 203 17 bacterial bacterial JJ cord-333405-ji58jbct 203 18 DNA dna NN cord-333405-ji58jbct 203 19 fragments fragment NNS cord-333405-ji58jbct 203 20 exert exert VBP cord-333405-ji58jbct 203 21 on on IN cord-333405-ji58jbct 203 22 the the DT cord-333405-ji58jbct 203 23 innate innate JJ cord-333405-ji58jbct 203 24 immune immune JJ cord-333405-ji58jbct 203 25 system system NN cord-333405-ji58jbct 203 26 . . . cord-333405-ji58jbct 204 1 These these DT cord-333405-ji58jbct 204 2 sequences sequence NNS cord-333405-ji58jbct 204 3 show show VBP cord-333405-ji58jbct 204 4 promise promise NN cord-333405-ji58jbct 204 5 as as IN cord-333405-ji58jbct 204 6 vaccine vaccine NN cord-333405-ji58jbct 204 7 adjuvants adjuvant NNS cord-333405-ji58jbct 204 8 that that WDT cord-333405-ji58jbct 204 9 accelerate accelerate VBP cord-333405-ji58jbct 204 10 and and CC cord-333405-ji58jbct 204 11 augment augment VB cord-333405-ji58jbct 204 12 immune immune JJ cord-333405-ji58jbct 204 13 responses response NNS cord-333405-ji58jbct 204 14 97 97 CD cord-333405-ji58jbct 204 15 . . . cord-333405-ji58jbct 205 1 We -PRON- PRP cord-333405-ji58jbct 205 2 can can MD cord-333405-ji58jbct 205 3 anticipate anticipate VB cord-333405-ji58jbct 205 4 more more JJR cord-333405-ji58jbct 205 5 progress progress NN cord-333405-ji58jbct 205 6 of of IN cord-333405-ji58jbct 205 7 this this DT cord-333405-ji58jbct 205 8 kind kind NN cord-333405-ji58jbct 205 9 as as IN cord-333405-ji58jbct 205 10 we -PRON- PRP cord-333405-ji58jbct 205 11 continue continue VBP cord-333405-ji58jbct 205 12 to to TO cord-333405-ji58jbct 205 13 delineate delineate VB cord-333405-ji58jbct 205 14 the the DT cord-333405-ji58jbct 205 15 complex complex JJ cord-333405-ji58jbct 205 16 interactions interaction NNS cord-333405-ji58jbct 205 17 between between IN cord-333405-ji58jbct 205 18 innate innate JJ cord-333405-ji58jbct 205 19 and and CC cord-333405-ji58jbct 205 20 adaptive adaptive JJ cord-333405-ji58jbct 205 21 immune immune JJ cord-333405-ji58jbct 205 22 responses response NNS cord-333405-ji58jbct 205 23 . . . cord-333405-ji58jbct 206 1 The the DT cord-333405-ji58jbct 206 2 sequencing sequencing NN cord-333405-ji58jbct 206 3 of of IN cord-333405-ji58jbct 206 4 the the DT cord-333405-ji58jbct 206 5 human human JJ cord-333405-ji58jbct 206 6 genome genome NN cord-333405-ji58jbct 206 7 , , , cord-333405-ji58jbct 206 8 the the DT cord-333405-ji58jbct 206 9 genomes genome NNS cord-333405-ji58jbct 206 10 of of IN cord-333405-ji58jbct 206 11 six six CD cord-333405-ji58jbct 206 12 other other JJ cord-333405-ji58jbct 206 13 animals animal NNS cord-333405-ji58jbct 206 14 , , , cord-333405-ji58jbct 206 15 including include VBG cord-333405-ji58jbct 206 16 the the DT cord-333405-ji58jbct 206 17 mouse mouse NN cord-333405-ji58jbct 206 18 , , , cord-333405-ji58jbct 206 19 and and CC cord-333405-ji58jbct 206 20 those those DT cord-333405-ji58jbct 206 21 of of IN cord-333405-ji58jbct 206 22 microbial microbial JJ cord-333405-ji58jbct 206 23 vectors vector NNS cord-333405-ji58jbct 206 24 and and CC cord-333405-ji58jbct 206 25 microbes microbe NNS cord-333405-ji58jbct 206 26 themselves -PRON- PRP cord-333405-ji58jbct 206 27 ( ( -LRB- cord-333405-ji58jbct 206 28 for for IN cord-333405-ji58jbct 206 29 example example NN cord-333405-ji58jbct 206 30 , , , cord-333405-ji58jbct 206 31 P. P. NNP cord-333405-ji58jbct 206 32 falciparum falciparum NN cord-333405-ji58jbct 206 33 and and CC cord-333405-ji58jbct 206 34 its -PRON- PRP$ cord-333405-ji58jbct 206 35 mosquito mosquito NN cord-333405-ji58jbct 206 36 vector vector NN cord-333405-ji58jbct 206 37 , , , cord-333405-ji58jbct 206 38 Anopheles Anopheles NNP cord-333405-ji58jbct 206 39 gambiae gambiae NN cord-333405-ji58jbct 206 40 ) ) -RRB- cord-333405-ji58jbct 206 41 , , , cord-333405-ji58jbct 206 42 have have VBP cord-333405-ji58jbct 206 43 elevated elevate VBN cord-333405-ji58jbct 206 44 microbiology microbiology NN cord-333405-ji58jbct 206 45 to to IN cord-333405-ji58jbct 206 46 a a DT cord-333405-ji58jbct 206 47 wholegenome wholegenome NN cord-333405-ji58jbct 206 48 level level NN cord-333405-ji58jbct 206 49 . . . cord-333405-ji58jbct 207 1 The the DT cord-333405-ji58jbct 207 2 ability ability NN cord-333405-ji58jbct 207 3 to to TO cord-333405-ji58jbct 207 4 sequence sequence VB cord-333405-ji58jbct 207 5 microbial microbial JJ cord-333405-ji58jbct 207 6 genomes genome NNS cord-333405-ji58jbct 207 7 in in IN cord-333405-ji58jbct 207 8 a a DT cord-333405-ji58jbct 207 9 few few JJ cord-333405-ji58jbct 207 10 days day NNS cord-333405-ji58jbct 207 11 98 98 CD cord-333405-ji58jbct 207 12 or or CC cord-333405-ji58jbct 207 13 less less JJR cord-333405-ji58jbct 207 14 , , , cord-333405-ji58jbct 207 15 and and CC cord-333405-ji58jbct 207 16 to to TO cord-333405-ji58jbct 207 17 examine examine VB cord-333405-ji58jbct 207 18 host host NN cord-333405-ji58jbct 207 19 - - HYPH cord-333405-ji58jbct 207 20 vector vector NN cord-333405-ji58jbct 207 21 - - HYPH cord-333405-ji58jbct 207 22 microbe microbe NN cord-333405-ji58jbct 207 23 interactions interaction NNS cord-333405-ji58jbct 207 24 at at IN cord-333405-ji58jbct 207 25 both both CC cord-333405-ji58jbct 207 26 the the DT cord-333405-ji58jbct 207 27 genome genome NN cord-333405-ji58jbct 207 28 level level NN cord-333405-ji58jbct 207 29 and and CC cord-333405-ji58jbct 207 30 at at IN cord-333405-ji58jbct 207 31 the the DT cord-333405-ji58jbct 207 32 tertiary tertiary JJ cord-333405-ji58jbct 207 33 protein protein NN cord-333405-ji58jbct 207 34 structural structural JJ cord-333405-ji58jbct 207 35 level level NN cord-333405-ji58jbct 207 36 , , , cord-333405-ji58jbct 207 37 will will MD cord-333405-ji58jbct 207 38 help help VB cord-333405-ji58jbct 207 39 us -PRON- PRP cord-333405-ji58jbct 207 40 to to TO cord-333405-ji58jbct 207 41 understand understand VB cord-333405-ji58jbct 207 42 the the DT cord-333405-ji58jbct 207 43 molecular molecular JJ cord-333405-ji58jbct 207 44 mechanisms mechanism NNS cord-333405-ji58jbct 207 45 that that WDT cord-333405-ji58jbct 207 46 underlie underlie VBP cord-333405-ji58jbct 207 47 the the DT cord-333405-ji58jbct 207 48 pathogenesis pathogenesis NN cord-333405-ji58jbct 207 49 of of IN cord-333405-ji58jbct 207 50 infectious infectious JJ cord-333405-ji58jbct 207 51 disease disease NN cord-333405-ji58jbct 207 52 and and CC cord-333405-ji58jbct 207 53 host host NN cord-333405-ji58jbct 207 54 defences defence NNS cord-333405-ji58jbct 207 55 , , , cord-333405-ji58jbct 207 56 including include VBG cord-333405-ji58jbct 207 57 resistance resistance NN cord-333405-ji58jbct 207 58 and and CC cord-333405-ji58jbct 207 59 immune immune JJ cord-333405-ji58jbct 207 60 evasion evasion NN cord-333405-ji58jbct 207 61 . . . cord-333405-ji58jbct 208 1 These these DT cord-333405-ji58jbct 208 2 advances advance NNS cord-333405-ji58jbct 208 3 will will MD cord-333405-ji58jbct 208 4 facilitate facilitate VB cord-333405-ji58jbct 208 5 the the DT cord-333405-ji58jbct 208 6 development development NN cord-333405-ji58jbct 208 7 of of IN cord-333405-ji58jbct 208 8 new new JJ cord-333405-ji58jbct 208 9 countermeasures countermeasure NNS cord-333405-ji58jbct 208 10 . . . cord-333405-ji58jbct 209 1 Other other JJ cord-333405-ji58jbct 209 2 fertile fertile JJ cord-333405-ji58jbct 209 3 areas area NNS cord-333405-ji58jbct 209 4 of of IN cord-333405-ji58jbct 209 5 research research NN cord-333405-ji58jbct 209 6 include include VBP cord-333405-ji58jbct 209 7 the the DT cord-333405-ji58jbct 209 8 use use NN cord-333405-ji58jbct 209 9 of of IN cord-333405-ji58jbct 209 10 geographical geographical JJ cord-333405-ji58jbct 209 11 information information NN cord-333405-ji58jbct 209 12 systems system NNS cord-333405-ji58jbct 209 13 99 99 CD cord-333405-ji58jbct 209 14 and and CC cord-333405-ji58jbct 209 15 satellite satellite NN cord-333405-ji58jbct 209 16 imaging imaging NN cord-333405-ji58jbct 209 17 to to TO cord-333405-ji58jbct 209 18 support support VB cord-333405-ji58jbct 209 19 field field NN cord-333405-ji58jbct 209 20 study study NN cord-333405-ji58jbct 209 21 and and CC cord-333405-ji58jbct 209 22 epidemic epidemic NN cord-333405-ji58jbct 209 23 prevention prevention NN cord-333405-ji58jbct 209 24 ( ( -LRB- cord-333405-ji58jbct 209 25 for for IN cord-333405-ji58jbct 209 26 example example NN cord-333405-ji58jbct 209 27 , , , cord-333405-ji58jbct 209 28 predicting predict VBG cord-333405-ji58jbct 209 29 HPS HPS NNP cord-333405-ji58jbct 209 30 and and CC cord-333405-ji58jbct 209 31 Rift Rift NNP cord-333405-ji58jbct 209 32 Valley Valley NNP cord-333405-ji58jbct 209 33 fever fever NN cord-333405-ji58jbct 209 34 epidemics epidemic NNS cord-333405-ji58jbct 209 35 in in IN cord-333405-ji58jbct 209 36 indigenous indigenous JJ cord-333405-ji58jbct 209 37 areas area NNS cord-333405-ji58jbct 209 38 by by IN cord-333405-ji58jbct 209 39 satellite satellite NN cord-333405-ji58jbct 209 40 imagery imagery NN cord-333405-ji58jbct 209 41 of of IN cord-333405-ji58jbct 209 42 water water NN cord-333405-ji58jbct 209 43 and and CC cord-333405-ji58jbct 209 44 vegetation vegetation NN cord-333405-ji58jbct 209 45 related relate VBN cord-333405-ji58jbct 209 46 to to IN cord-333405-ji58jbct 209 47 animal animal NN cord-333405-ji58jbct 209 48 reservoir reservoir NN cord-333405-ji58jbct 209 49 and and CC cord-333405-ji58jbct 209 50 vector vector NN cord-333405-ji58jbct 209 51 prevalence prevalence NN cord-333405-ji58jbct 209 52 ) ) -RRB- cord-333405-ji58jbct 209 53 . . . cord-333405-ji58jbct 210 1 Underlying underlie VBG cord-333405-ji58jbct 210 2 disease disease NN cord-333405-ji58jbct 210 3 emergence emergence NN cord-333405-ji58jbct 210 4 are be VBP cord-333405-ji58jbct 210 5 evolutionary evolutionary JJ cord-333405-ji58jbct 210 6 conflicts conflict NNS cord-333405-ji58jbct 210 7 between between IN cord-333405-ji58jbct 210 8 rapidly rapidly RB cord-333405-ji58jbct 210 9 evolving evolve VBG cord-333405-ji58jbct 210 10 and and CC cord-333405-ji58jbct 210 11 adapting adapt VBG cord-333405-ji58jbct 210 12 infectious infectious JJ cord-333405-ji58jbct 210 13 agents agent NNS cord-333405-ji58jbct 210 14 and and CC cord-333405-ji58jbct 210 15 their -PRON- PRP$ cord-333405-ji58jbct 210 16 slowly slowly RB cord-333405-ji58jbct 210 17 evolving evolve VBG cord-333405-ji58jbct 210 18 hosts host NNS cord-333405-ji58jbct 210 19 . . . cord-333405-ji58jbct 211 1 These these DT cord-333405-ji58jbct 211 2 are be VBP cord-333405-ji58jbct 211 3 fought fight VBN cord-333405-ji58jbct 211 4 out out RP cord-333405-ji58jbct 211 5 in in IN cord-333405-ji58jbct 211 6 the the DT cord-333405-ji58jbct 211 7 context context NN cord-333405-ji58jbct 211 8 of of IN cord-333405-ji58jbct 211 9 accelerating accelerate VBG cord-333405-ji58jbct 211 10 environmental environmental JJ cord-333405-ji58jbct 211 11 and and CC cord-333405-ji58jbct 211 12 human human JJ cord-333405-ji58jbct 211 13 behavioural behavioural JJ cord-333405-ji58jbct 211 14 alterations alteration NNS cord-333405-ji58jbct 211 15 that that WDT cord-333405-ji58jbct 211 16 provide provide VBP cord-333405-ji58jbct 211 17 new new JJ cord-333405-ji58jbct 211 18 ecological ecological JJ cord-333405-ji58jbct 211 19 niches niche NNS cord-333405-ji58jbct 211 20 into into IN cord-333405-ji58jbct 211 21 which which WDT cord-333405-ji58jbct 211 22 evolving evolve VBG cord-333405-ji58jbct 211 23 microbes microbe NNS cord-333405-ji58jbct 211 24 can can MD cord-333405-ji58jbct 211 25 readily readily RB cord-333405-ji58jbct 211 26 fit fit VB cord-333405-ji58jbct 211 27 . . . cord-333405-ji58jbct 212 1 It -PRON- PRP cord-333405-ji58jbct 212 2 is be VBZ cord-333405-ji58jbct 212 3 essential essential JJ cord-333405-ji58jbct 212 4 that that IN cord-333405-ji58jbct 212 5 broadly broadly RB cord-333405-ji58jbct 212 6 based base VBN cord-333405-ji58jbct 212 7 prevention prevention NN cord-333405-ji58jbct 212 8 strategies strategy NNS cord-333405-ji58jbct 212 9 , , , cord-333405-ji58jbct 212 10 as as RB cord-333405-ji58jbct 212 11 well well RB cord-333405-ji58jbct 212 12 as as IN cord-333405-ji58jbct 212 13 new new JJ cord-333405-ji58jbct 212 14 and and CC cord-333405-ji58jbct 212 15 improved improved JJ cord-333405-ji58jbct 212 16 countermeasures countermeasure NNS cord-333405-ji58jbct 212 17 ( ( -LRB- cord-333405-ji58jbct 212 18 that that RB cord-333405-ji58jbct 212 19 is is RB cord-333405-ji58jbct 212 20 , , , cord-333405-ji58jbct 212 21 surveillance surveillance NN cord-333405-ji58jbct 212 22 tools tool NNS cord-333405-ji58jbct 212 23 , , , cord-333405-ji58jbct 212 24 diagnostics diagnostic NNS cord-333405-ji58jbct 212 25 , , , cord-333405-ji58jbct 212 26 therapeutics therapeutic NNS cord-333405-ji58jbct 212 27 and and CC cord-333405-ji58jbct 212 28 vaccines vaccine NNS cord-333405-ji58jbct 212 29 ) ) -RRB- cord-333405-ji58jbct 212 30 , , , cord-333405-ji58jbct 212 31 be be VB cord-333405-ji58jbct 212 32 continually continually RB cord-333405-ji58jbct 212 33 tested test VBN cord-333405-ji58jbct 212 34 , , , cord-333405-ji58jbct 212 35 refined refined JJ cord-333405-ji58jbct 212 36 and and CC cord-333405-ji58jbct 212 37 upgraded upgrade VBN cord-333405-ji58jbct 212 38 , , , cord-333405-ji58jbct 212 39 requiring require VBG cord-333405-ji58jbct 212 40 a a DT cord-333405-ji58jbct 212 41 strengthened strengthen VBN cord-333405-ji58jbct 212 42 relationship relationship NN cord-333405-ji58jbct 212 43 between between IN cord-333405-ji58jbct 212 44 public public JJ cord-333405-ji58jbct 212 45 health health NN cord-333405-ji58jbct 212 46 and and CC cord-333405-ji58jbct 212 47 basic basic JJ cord-333405-ji58jbct 212 48 and and CC cord-333405-ji58jbct 212 49 clinical clinical JJ cord-333405-ji58jbct 212 50 sciences science NNS cord-333405-ji58jbct 212 51 . . . cord-333405-ji58jbct 213 1 The the DT cord-333405-ji58jbct 213 2 challenge challenge NN cord-333405-ji58jbct 213 3 presented present VBN cord-333405-ji58jbct 213 4 by by IN cord-333405-ji58jbct 213 5 the the DT cord-333405-ji58jbct 213 6 ongoing ongoing JJ cord-333405-ji58jbct 213 7 conflict conflict NN cord-333405-ji58jbct 213 8 between between IN cord-333405-ji58jbct 213 9 pathogenic pathogenic JJ cord-333405-ji58jbct 213 10 microorganisms microorganism NNS cord-333405-ji58jbct 213 11 and and CC cord-333405-ji58jbct 213 12 man man NN cord-333405-ji58jbct 213 13 has have VBZ cord-333405-ji58jbct 213 14 been be VBN cord-333405-ji58jbct 213 15 well well RB cord-333405-ji58jbct 213 16 summarized summarize VBN cord-333405-ji58jbct 213 17 by by IN cord-333405-ji58jbct 213 18 a a DT cord-333405-ji58jbct 213 19 noted note VBN cord-333405-ji58jbct 213 20 champion champion NN cord-333405-ji58jbct 213 21 of of IN cord-333405-ji58jbct 213 22 the the DT cord-333405-ji58jbct 213 23 war war NN cord-333405-ji58jbct 213 24 on on IN cord-333405-ji58jbct 213 25 EIs EIs NNP cord-333405-ji58jbct 213 26 , , , cord-333405-ji58jbct 213 27 Joshua Joshua NNP cord-333405-ji58jbct 213 28 Lederberg Lederberg NNP cord-333405-ji58jbct 213 29 : : : cord-333405-ji58jbct 213 30 " " `` cord-333405-ji58jbct 213 31 The the DT cord-333405-ji58jbct 213 32 future future NN cord-333405-ji58jbct 213 33 of of IN cord-333405-ji58jbct 213 34 microbes microbe NNS cord-333405-ji58jbct 213 35 and and CC cord-333405-ji58jbct 213 36 mankind mankind NN cord-333405-ji58jbct 213 37 will will MD cord-333405-ji58jbct 213 38 probably probably RB cord-333405-ji58jbct 213 39 unfold unfold VB cord-333405-ji58jbct 213 40 as as IN cord-333405-ji58jbct 213 41 episodes episode NNS cord-333405-ji58jbct 213 42 of of IN cord-333405-ji58jbct 213 43 a a DT cord-333405-ji58jbct 213 44 suspense suspense NN cord-333405-ji58jbct 213 45 thriller thriller NN cord-333405-ji58jbct 213 46 that that WDT cord-333405-ji58jbct 213 47 could could MD cord-333405-ji58jbct 213 48 be be VB cord-333405-ji58jbct 213 49 entitled entitle VBN cord-333405-ji58jbct 213 50 Our -PRON- PRP$ cord-333405-ji58jbct 213 51 Wits wit NNS cord-333405-ji58jbct 213 52 Versus versus IN cord-333405-ji58jbct 213 53 Their -PRON- PRP$ cord-333405-ji58jbct 213 54 Genes Genes NNPS cord-333405-ji58jbct 213 55 " " '' cord-333405-ji58jbct 213 56 29 29 CD cord-333405-ji58jbct 213 57 . . . cord-333405-ji58jbct 214 1 The the DT cord-333405-ji58jbct 214 2 global global JJ cord-333405-ji58jbct 214 3 scientific scientific JJ cord-333405-ji58jbct 214 4 and and CC cord-333405-ji58jbct 214 5 public public JJ cord-333405-ji58jbct 214 6 health health NN cord-333405-ji58jbct 214 7 communities community NNS cord-333405-ji58jbct 214 8 must must MD cord-333405-ji58jbct 214 9 confront confront VB cord-333405-ji58jbct 214 10 this this DT cord-333405-ji58jbct 214 11 reality reality NN cord-333405-ji58jbct 214 12 not not RB cord-333405-ji58jbct 214 13 only only RB cord-333405-ji58jbct 214 14 with with IN cord-333405-ji58jbct 214 15 wit wit NN cord-333405-ji58jbct 214 16 , , , cord-333405-ji58jbct 214 17 but but CC cord-333405-ji58jbct 214 18 also also RB cord-333405-ji58jbct 214 19 with with IN cord-333405-ji58jbct 214 20 vision vision NN cord-333405-ji58jbct 214 21 and and CC cord-333405-ji58jbct 214 22 sustained sustained JJ cord-333405-ji58jbct 214 23 commitment commitment NN cord-333405-ji58jbct 214 24 to to TO cord-333405-ji58jbct 214 25 meet meet VB cord-333405-ji58jbct 214 26 a a DT cord-333405-ji58jbct 214 27 perpetual perpetual JJ cord-333405-ji58jbct 214 28 challenge challenge NN cord-333405-ji58jbct 214 29 . . . cord-333405-ji58jbct 215 1 In in IN cord-333405-ji58jbct 215 2 Figure figure NN cord-333405-ji58jbct 215 3 2 2 CD cord-333405-ji58jbct 215 4 of of IN cord-333405-ji58jbct 215 5 this this DT cord-333405-ji58jbct 215 6 Review Review NNP cord-333405-ji58jbct 215 7 , , , cord-333405-ji58jbct 215 8 the the DT cord-333405-ji58jbct 215 9 pie pie NN cord-333405-ji58jbct 215 10 chart chart NN cord-333405-ji58jbct 215 11 was be VBD cord-333405-ji58jbct 215 12 drawn draw VBN cord-333405-ji58jbct 215 13 incorrectly incorrectly RB cord-333405-ji58jbct 215 14 , , , cord-333405-ji58jbct 215 15 with with IN cord-333405-ji58jbct 215 16 the the DT cord-333405-ji58jbct 215 17 wedge wedge NN cord-333405-ji58jbct 215 18 sizes size NNS cord-333405-ji58jbct 215 19 not not RB cord-333405-ji58jbct 215 20 in in IN cord-333405-ji58jbct 215 21 proportion proportion NN cord-333405-ji58jbct 215 22 to to IN cord-333405-ji58jbct 215 23 the the DT cord-333405-ji58jbct 215 24 total total JJ cord-333405-ji58jbct 215 25 size size NN cord-333405-ji58jbct 215 26 . . . cord-333405-ji58jbct 216 1 The the DT cord-333405-ji58jbct 216 2 correct correct JJ cord-333405-ji58jbct 216 3 figure figure NN cord-333405-ji58jbct 216 4 is be VBZ cord-333405-ji58jbct 216 5 shown show VBN cord-333405-ji58jbct 216 6 below below RB cord-333405-ji58jbct 216 7 . . . cord-333405-ji58jbct 216 8 _SP cord-333405-ji58jbct 217 1 Asthma asthma NN cord-333405-ji58jbct 217 2 and and CC cord-333405-ji58jbct 217 3 chronic chronic JJ cord-333405-ji58jbct 217 4 obstructive obstructive JJ cord-333405-ji58jbct 217 5 pulmonary pulmonary JJ cord-333405-ji58jbct 217 6 disease disease NN cord-333405-ji58jbct 218 1 3.0 3.0 CD cord-333405-ji58jbct 218 2 million million CD cord-333405-ji58jbct 218 3 Factors factor NNS cord-333405-ji58jbct 218 4 in in IN cord-333405-ji58jbct 218 5 the the DT cord-333405-ji58jbct 218 6 emergence emergence NN cord-333405-ji58jbct 218 7 of of IN cord-333405-ji58jbct 218 8 infectious infectious JJ cord-333405-ji58jbct 218 9 diseases disease NNS cord-333405-ji58jbct 219 1 The the DT cord-333405-ji58jbct 219 2 Wordsworth Wordsworth NNP cord-333405-ji58jbct 219 3 Encyclopedia Encyclopedia NNP cord-333405-ji58jbct 219 4 of of IN cord-333405-ji58jbct 219 5 Plague Plague NNP cord-333405-ji58jbct 219 6 and and CC cord-333405-ji58jbct 219 7 Pestilence pestilence NN cord-333405-ji58jbct 219 8 Updating update VBG cord-333405-ji58jbct 219 9 the the DT cord-333405-ji58jbct 219 10 accounts account NNS cord-333405-ji58jbct 219 11 : : : cord-333405-ji58jbct 219 12 global global JJ cord-333405-ji58jbct 219 13 mortality mortality NN cord-333405-ji58jbct 219 14 of of IN cord-333405-ji58jbct 219 15 the the DT cord-333405-ji58jbct 219 16 1918 1918 CD cord-333405-ji58jbct 219 17 - - SYM cord-333405-ji58jbct 219 18 1920 1920 CD cord-333405-ji58jbct 219 19 " " `` cord-333405-ji58jbct 219 20 Spanish spanish JJ cord-333405-ji58jbct 219 21 " " '' cord-333405-ji58jbct 219 22 influenza influenza NN cord-333405-ji58jbct 219 23 pandemic pandemic NN cord-333405-ji58jbct 219 24 Centers Centers NNPS cord-333405-ji58jbct 219 25 for for IN cord-333405-ji58jbct 219 26 Disease Disease NNP cord-333405-ji58jbct 219 27 Control Control NNP cord-333405-ji58jbct 219 28 and and CC cord-333405-ji58jbct 219 29 Prevention Prevention NNP cord-333405-ji58jbct 219 30 . . . cord-333405-ji58jbct 220 1 Multistate multistate JJ cord-333405-ji58jbct 220 2 outbreak outbreak NN cord-333405-ji58jbct 220 3 of of IN cord-333405-ji58jbct 220 4 monkeypox monkeypox NNP cord-333405-ji58jbct 220 5 -Illinois -Illinois . cord-333405-ji58jbct 221 1 The the DT cord-333405-ji58jbct 221 2 severe severe JJ cord-333405-ji58jbct 221 3 acute acute JJ cord-333405-ji58jbct 221 4 respiratory respiratory JJ cord-333405-ji58jbct 221 5 syndrome syndrome NN cord-333405-ji58jbct 221 6 Investigation investigation NN cord-333405-ji58jbct 221 7 of of IN cord-333405-ji58jbct 221 8 bioterrorism bioterrorism NN cord-333405-ji58jbct 221 9 - - HYPH cord-333405-ji58jbct 221 10 related relate VBN cord-333405-ji58jbct 221 11 anthrax anthrax NN cord-333405-ji58jbct 221 12 , , , cord-333405-ji58jbct 221 13 United United NNP cord-333405-ji58jbct 221 14 States States NNP cord-333405-ji58jbct 221 15 , , , cord-333405-ji58jbct 221 16 2001 2001 CD cord-333405-ji58jbct 221 17 : : : cord-333405-ji58jbct 221 18 epidemiologic epidemiologic JJ cord-333405-ji58jbct 221 19 findings finding NNS cord-333405-ji58jbct 221 20 Threats threat NNS cord-333405-ji58jbct 221 21 to to IN cord-333405-ji58jbct 221 22 global global JJ cord-333405-ji58jbct 221 23 health health NN cord-333405-ji58jbct 221 24 and and CC cord-333405-ji58jbct 221 25 survival survival NN cord-333405-ji58jbct 221 26 : : : cord-333405-ji58jbct 222 1 the the DT cord-333405-ji58jbct 222 2 growing grow VBG cord-333405-ji58jbct 222 3 crises crisis NNS cord-333405-ji58jbct 222 4 of of IN cord-333405-ji58jbct 222 5 tropical tropical JJ cord-333405-ji58jbct 222 6 infectious infectious JJ cord-333405-ji58jbct 222 7 diseases disease NNS cord-333405-ji58jbct 222 8 -an -an : cord-333405-ji58jbct 222 9 " " `` cord-333405-ji58jbct 222 10 unfinished unfinished JJ cord-333405-ji58jbct 222 11 " " '' cord-333405-ji58jbct 222 12 agenda agenda NN cord-333405-ji58jbct 222 13 Emerging emerge VBG cord-333405-ji58jbct 222 14 infectious infectious JJ cord-333405-ji58jbct 222 15 diseases disease NNS cord-333405-ji58jbct 222 16 among among IN cord-333405-ji58jbct 222 17 indigenous indigenous JJ cord-333405-ji58jbct 222 18 peoples people NNS cord-333405-ji58jbct 223 1 ǼșȓȖșȕșȍȓȊ ǼșȓȖșȕșȍȓȊ NFP cord-333405-ji58jbct 224 1 -sive -sive JJ cord-333405-ji58jbct 224 2 , , , cord-333405-ji58jbct 224 3 Pestis Pestis NNP cord-333405-ji58jbct 224 4 Nuperae Nuperae NNP cord-333405-ji58jbct 224 5 apud apud XX cord-333405-ji58jbct 225 1 Populum Populum NNP cord-333405-ji58jbct 226 1 Londinensem Londinensem NNP cord-333405-ji58jbct 226 2 Grassantis Grassantis NNP cord-333405-ji58jbct 227 1 Narratio Narratio NNP cord-333405-ji58jbct 227 2 Historica Historica NNP cord-333405-ji58jbct 227 3 Epidemiology Epidemiology NNP cord-333405-ji58jbct 227 4 of of IN cord-333405-ji58jbct 227 5 the the DT cord-333405-ji58jbct 227 6 Plague Plague NNP cord-333405-ji58jbct 227 7 of of IN cord-333405-ji58jbct 227 8 Athens Athens NNP cord-333405-ji58jbct 228 1 The the DT cord-333405-ji58jbct 228 2 Columbian Columbian NNP cord-333405-ji58jbct 228 3 Exchange Exchange NNP cord-333405-ji58jbct 228 4 : : : cord-333405-ji58jbct 228 5 Biological Biological NNP cord-333405-ji58jbct 228 6 and and CC cord-333405-ji58jbct 228 7 Cultural Cultural NNP cord-333405-ji58jbct 228 8 Consequences consequence NNS cord-333405-ji58jbct 228 9 of of IN cord-333405-ji58jbct 228 10 1492 1492 CD cord-333405-ji58jbct 228 11 Princes Princes NNPS cord-333405-ji58jbct 228 12 and and CC cord-333405-ji58jbct 228 13 Peasants Peasants NNPS cord-333405-ji58jbct 228 14 . . . cord-333405-ji58jbct 229 1 Smallpox smallpox NN cord-333405-ji58jbct 229 2 in in IN cord-333405-ji58jbct 229 3 History History NNP cord-333405-ji58jbct 229 4 Ch Ch NNP cord-333405-ji58jbct 229 5 Island Island NNP cord-333405-ji58jbct 229 6 Populations Populations NNPS cord-333405-ji58jbct 229 7 of of IN cord-333405-ji58jbct 229 8 the the DT cord-333405-ji58jbct 229 9 Pacific Pacific NNP cord-333405-ji58jbct 230 1 The the DT cord-333405-ji58jbct 230 2 Gifts gift NNS cord-333405-ji58jbct 230 3 of of IN cord-333405-ji58jbct 230 4 Civilization Civilization NNP cord-333405-ji58jbct 230 5 . . . cord-333405-ji58jbct 231 1 Germs germ NNS cord-333405-ji58jbct 231 2 and and CC cord-333405-ji58jbct 231 3 Genocide Genocide NNP cord-333405-ji58jbct 231 4 in in IN cord-333405-ji58jbct 231 5 Hawai'i Hawai'i NNP cord-333405-ji58jbct 231 6 Agents Agents NNPS cord-333405-ji58jbct 231 7 of of IN cord-333405-ji58jbct 231 8 Apocalypse Apocalypse NNP cord-333405-ji58jbct 231 9 : : : cord-333405-ji58jbct 231 10 Epidemic Epidemic NNP cord-333405-ji58jbct 231 11 Disease Disease NNP cord-333405-ji58jbct 231 12 in in IN cord-333405-ji58jbct 231 13 the the DT cord-333405-ji58jbct 231 14 Colonial Colonial NNP cord-333405-ji58jbct 231 15 Philippines Philippines NNP cord-333405-ji58jbct 231 16 Measles Measles NNP cord-333405-ji58jbct 231 17 in in IN cord-333405-ji58jbct 231 18 Fiji Fiji NNP cord-333405-ji58jbct 231 19 , , , cord-333405-ji58jbct 231 20 1875 1875 CD cord-333405-ji58jbct 231 21 : : : cord-333405-ji58jbct 231 22 thoughts thought NNS cord-333405-ji58jbct 231 23 on on IN cord-333405-ji58jbct 231 24 the the DT cord-333405-ji58jbct 231 25 history history NN cord-333405-ji58jbct 231 26 of of IN cord-333405-ji58jbct 231 27 emerging emerge VBG cord-333405-ji58jbct 231 28 infectious infectious JJ cord-333405-ji58jbct 231 29 diseases disease NNS cord-333405-ji58jbct 231 30 Die die VBP cord-333405-ji58jbct 232 1 Aetiologie Aetiologie NNP cord-333405-ji58jbct 232 2 der der NNP cord-333405-ji58jbct 232 3 Milzbrand Milzbrand NNP cord-333405-ji58jbct 232 4 - - HYPH cord-333405-ji58jbct 232 5 Krankheit Krankheit NNP cord-333405-ji58jbct 232 6 , , , cord-333405-ji58jbct 232 7 begründet begründet NNP cord-333405-ji58jbct 232 8 auf auf NNP cord-333405-ji58jbct 232 9 die die VBP cord-333405-ji58jbct 232 10 Entwicklungsgeschichte Entwicklungsgeschichte NNP cord-333405-ji58jbct 232 11 des des FW cord-333405-ji58jbct 232 12 Bacillus Bacillus NNP cord-333405-ji58jbct 232 13 Anthracis Anthracis NNP cord-333405-ji58jbct 232 14 . . . cord-333405-ji58jbct 233 1 Beiträge Beiträge NNP cord-333405-ji58jbct 233 2 zur zur NNP cord-333405-ji58jbct 233 3 Biologie Biologie NNP cord-333405-ji58jbct 233 4 der der NNP cord-333405-ji58jbct 233 5 Pflanzen Pflanzen NNP cord-333405-ji58jbct 234 1 Spreading spread VBG cord-333405-ji58jbct 234 2 Germs germ NNS cord-333405-ji58jbct 234 3 : : : cord-333405-ji58jbct 234 4 Diseases disease NNS cord-333405-ji58jbct 234 5 , , , cord-333405-ji58jbct 234 6 Theories Theories NNPS cord-333405-ji58jbct 234 7 , , , cord-333405-ji58jbct 234 8 and and CC cord-333405-ji58jbct 234 9 Medical Medical NNP cord-333405-ji58jbct 234 10 Practice Practice NNP cord-333405-ji58jbct 234 11 in in IN cord-333405-ji58jbct 234 12 Britain Britain NNP cord-333405-ji58jbct 235 1 The the DT cord-333405-ji58jbct 235 2 Greatest Greatest NNP cord-333405-ji58jbct 235 3 Benefit Benefit NNP cord-333405-ji58jbct 235 4 to to IN cord-333405-ji58jbct 235 5 Mankind mankind NN cord-333405-ji58jbct 235 6 : : : cord-333405-ji58jbct 235 7 A a DT cord-333405-ji58jbct 235 8 Medical medical JJ cord-333405-ji58jbct 235 9 History history NN cord-333405-ji58jbct 235 10 of of IN cord-333405-ji58jbct 235 11 Humanity humanity NN cord-333405-ji58jbct 235 12 from from IN cord-333405-ji58jbct 235 13 Antiquity Antiquity NNP cord-333405-ji58jbct 235 14 to to IN cord-333405-ji58jbct 235 15 the the DT cord-333405-ji58jbct 235 16 Present Present NNP cord-333405-ji58jbct 236 1 The the DT cord-333405-ji58jbct 236 2 extermination extermination NN cord-333405-ji58jbct 236 3 of of IN cord-333405-ji58jbct 236 4 infectious infectious JJ cord-333405-ji58jbct 236 5 diseases disease NNS cord-333405-ji58jbct 237 1 The the DT cord-333405-ji58jbct 237 2 Evolution Evolution NNP cord-333405-ji58jbct 237 3 and and CC cord-333405-ji58jbct 237 4 Eradication eradication NN cord-333405-ji58jbct 237 5 of of IN cord-333405-ji58jbct 237 6 Infectious Infectious NNP cord-333405-ji58jbct 237 7 Diseases Diseases NNPS cord-333405-ji58jbct 237 8 Infectious infectious JJ cord-333405-ji58jbct 237 9 diseases disease NNS cord-333405-ji58jbct 237 10 : : : cord-333405-ji58jbct 237 11 considerations consideration NNS cord-333405-ji58jbct 237 12 for for IN cord-333405-ji58jbct 237 13 the the DT cord-333405-ji58jbct 237 14 21st 21st JJ cord-333405-ji58jbct 237 15 century century NN cord-333405-ji58jbct 238 1 The the DT cord-333405-ji58jbct 238 2 Restless Restless NNP cord-333405-ji58jbct 238 3 Tide Tide NNP cord-333405-ji58jbct 238 4 : : : cord-333405-ji58jbct 239 1 The the DT cord-333405-ji58jbct 239 2 Persistent Persistent NNP cord-333405-ji58jbct 239 3 Challenge Challenge NNP cord-333405-ji58jbct 239 4 of of IN cord-333405-ji58jbct 239 5 the the DT cord-333405-ji58jbct 239 6 Microbial Microbial NNP cord-333405-ji58jbct 239 7 World World NNP cord-333405-ji58jbct 239 8 ( ( -LRB- cord-333405-ji58jbct 239 9 National National NNP cord-333405-ji58jbct 239 10 Foundation Foundation NNP cord-333405-ji58jbct 239 11 for for IN cord-333405-ji58jbct 239 12 Infectious Infectious NNP cord-333405-ji58jbct 239 13 Diseases Diseases NNPS cord-333405-ji58jbct 239 14 Committee Committee NNP cord-333405-ji58jbct 239 15 on on IN cord-333405-ji58jbct 239 16 Emerging Emerging NNP cord-333405-ji58jbct 239 17 Microbial Microbial NNP cord-333405-ji58jbct 239 18 Threats Threats NNPS cord-333405-ji58jbct 239 19 to to IN cord-333405-ji58jbct 239 20 Health Health NNP cord-333405-ji58jbct 239 21 . . . cord-333405-ji58jbct 240 1 Emerging emerge VBG cord-333405-ji58jbct 240 2 Infections infection NNS cord-333405-ji58jbct 240 3 . . . cord-333405-ji58jbct 241 1 Microbial microbial JJ cord-333405-ji58jbct 241 2 Threats Threats NNPS cord-333405-ji58jbct 241 3 to to IN cord-333405-ji58jbct 241 4 Health Health NNP cord-333405-ji58jbct 241 5 in in IN cord-333405-ji58jbct 241 6 the the DT cord-333405-ji58jbct 241 7 United United NNP cord-333405-ji58jbct 241 8 States States NNP cord-333405-ji58jbct 241 9 Committee Committee NNP cord-333405-ji58jbct 241 10 on on IN cord-333405-ji58jbct 241 11 Emerging Emerging NNP cord-333405-ji58jbct 241 12 Microbial Microbial NNP cord-333405-ji58jbct 241 13 Threats Threats NNPS cord-333405-ji58jbct 241 14 to to IN cord-333405-ji58jbct 241 15 Health Health NNP cord-333405-ji58jbct 241 16 in in IN cord-333405-ji58jbct 241 17 the the DT cord-333405-ji58jbct 241 18 21st 21st JJ cord-333405-ji58jbct 241 19 Century century NN cord-333405-ji58jbct 241 20 . . . cord-333405-ji58jbct 242 1 Microbial microbial JJ cord-333405-ji58jbct 242 2 Threats Threats NNPS cord-333405-ji58jbct 242 3 to to IN cord-333405-ji58jbct 242 4 Health Health NNP cord-333405-ji58jbct 242 5 in in IN cord-333405-ji58jbct 242 6 the the DT cord-333405-ji58jbct 242 7 United United NNP cord-333405-ji58jbct 242 8 States States NNP cord-333405-ji58jbct 242 9 : : : cord-333405-ji58jbct 242 10 Emergence Emergence NNP cord-333405-ji58jbct 242 11 , , , cord-333405-ji58jbct 242 12 Detection Detection NNP cord-333405-ji58jbct 242 13 and and CC cord-333405-ji58jbct 242 14 Response Response NNP cord-333405-ji58jbct 242 15 Emerging Emerging NNP cord-333405-ji58jbct 242 16 and and CC cord-333405-ji58jbct 242 17 re re JJ cord-333405-ji58jbct 242 18 - - JJ cord-333405-ji58jbct 242 19 emerging emerge VBG cord-333405-ji58jbct 242 20 infectious infectious JJ cord-333405-ji58jbct 242 21 diseases disease NNS cord-333405-ji58jbct 242 22 : : : cord-333405-ji58jbct 242 23 a a DT cord-333405-ji58jbct 242 24 multidisciplinary multidisciplinary JJ cord-333405-ji58jbct 242 25 perspective perspective NN cord-333405-ji58jbct 242 26 Emerging Emerging NNP cord-333405-ji58jbct 242 27 and and CC cord-333405-ji58jbct 242 28 re re JJ cord-333405-ji58jbct 242 29 - - JJ cord-333405-ji58jbct 242 30 emerging emerge VBG cord-333405-ji58jbct 242 31 infectious infectious JJ cord-333405-ji58jbct 242 32 diseases disease NNS cord-333405-ji58jbct 242 33 Infectious infectious JJ cord-333405-ji58jbct 242 34 history history NN cord-333405-ji58jbct 243 1 Emerging emerge VBG cord-333405-ji58jbct 243 2 infectious infectious JJ cord-333405-ji58jbct 243 3 diseases disease NNS cord-333405-ji58jbct 243 4 in in IN cord-333405-ji58jbct 243 5 the the DT cord-333405-ji58jbct 243 6 21st 21st JJ cord-333405-ji58jbct 243 7 century century NN cord-333405-ji58jbct 243 8 Emerging Emerging NNP cord-333405-ji58jbct 243 9 and and CC cord-333405-ji58jbct 243 10 re re JJ cord-333405-ji58jbct 243 11 - - JJ cord-333405-ji58jbct 243 12 emerging emerge VBG cord-333405-ji58jbct 243 13 infectious infectious JJ cord-333405-ji58jbct 243 14 diseases disease NNS cord-333405-ji58jbct 243 15 Human Human NNP cord-333405-ji58jbct 243 16 Frontiers Frontiers NNPS cord-333405-ji58jbct 243 17 , , , cord-333405-ji58jbct 243 18 Environments Environments NNPS cord-333405-ji58jbct 243 19 and and CC cord-333405-ji58jbct 243 20 Disease Disease NNP cord-333405-ji58jbct 244 1 The the DT cord-333405-ji58jbct 244 2 origins origin NNS cord-333405-ji58jbct 244 3 of of IN cord-333405-ji58jbct 244 4 acquired acquire VBN cord-333405-ji58jbct 244 5 immune immune JJ cord-333405-ji58jbct 244 6 deficiency deficiency NN cord-333405-ji58jbct 244 7 viruses virus NNS cord-333405-ji58jbct 244 8 : : : cord-333405-ji58jbct 244 9 where where WRB cord-333405-ji58jbct 244 10 and and CC cord-333405-ji58jbct 244 11 when when WRB cord-333405-ji58jbct 244 12 ? ? . cord-333405-ji58jbct 245 1 Phil Phil NNP cord-333405-ji58jbct 245 2 Population Population NNP cord-333405-ji58jbct 245 3 migration migration NN cord-333405-ji58jbct 245 4 and and CC cord-333405-ji58jbct 245 5 the the DT cord-333405-ji58jbct 245 6 spread spread NN cord-333405-ji58jbct 245 7 of of IN cord-333405-ji58jbct 245 8 types type NNS cord-333405-ji58jbct 245 9 1 1 CD cord-333405-ji58jbct 245 10 and and CC cord-333405-ji58jbct 245 11 2 2 CD cord-333405-ji58jbct 245 12 human human JJ cord-333405-ji58jbct 245 13 immunodeficiency immunodeficiency NN cord-333405-ji58jbct 245 14 viruses virus NNS cord-333405-ji58jbct 246 1 The the DT cord-333405-ji58jbct 246 2 AIDS AIDS NNP cord-333405-ji58jbct 246 3 Knowledge Knowledge NNP cord-333405-ji58jbct 246 4 Base Base NNP cord-333405-ji58jbct 246 5 Slowing slow VBG cord-333405-ji58jbct 246 6 heterosexual heterosexual JJ cord-333405-ji58jbct 246 7 HIV HIV NNP cord-333405-ji58jbct 246 8 transmission transmission NN cord-333405-ji58jbct 246 9 A a DT cord-333405-ji58jbct 246 10 novel novel JJ cord-333405-ji58jbct 246 11 hantavirus hantavirus NN cord-333405-ji58jbct 246 12 associated associate VBN cord-333405-ji58jbct 246 13 with with IN cord-333405-ji58jbct 246 14 an an DT cord-333405-ji58jbct 246 15 outbreak outbreak NN cord-333405-ji58jbct 246 16 of of IN cord-333405-ji58jbct 246 17 fatal fatal JJ cord-333405-ji58jbct 246 18 respiratory respiratory JJ cord-333405-ji58jbct 246 19 disease disease NN cord-333405-ji58jbct 246 20 in in IN cord-333405-ji58jbct 246 21 the the DT cord-333405-ji58jbct 246 22 southwestern southwestern JJ cord-333405-ji58jbct 246 23 United United NNP cord-333405-ji58jbct 246 24 States States NNP cord-333405-ji58jbct 246 25 : : : cord-333405-ji58jbct 246 26 evolutionary evolutionary JJ cord-333405-ji58jbct 246 27 relationships relationship NNS cord-333405-ji58jbct 246 28 to to IN cord-333405-ji58jbct 246 29 known know VBN cord-333405-ji58jbct 246 30 hantaviruses hantaviruse NNS cord-333405-ji58jbct 247 1 Nipah Nipah NNP cord-333405-ji58jbct 247 2 virus virus NN cord-333405-ji58jbct 247 3 : : : cord-333405-ji58jbct 247 4 a a DT cord-333405-ji58jbct 247 5 recently recently RB cord-333405-ji58jbct 247 6 emergent emergent JJ cord-333405-ji58jbct 247 7 deadly deadly JJ cord-333405-ji58jbct 247 8 paramyxovirus paramyxovirus JJ cord-333405-ji58jbct 247 9 Variant Variant NNP cord-333405-ji58jbct 247 10 Creutzfeldt Creutzfeldt NNP cord-333405-ji58jbct 247 11 - - HYPH cord-333405-ji58jbct 247 12 Jakob Jakob NNP cord-333405-ji58jbct 247 13 disease disease NN cord-333405-ji58jbct 247 14 and and CC cord-333405-ji58jbct 247 15 the the DT cord-333405-ji58jbct 247 16 acquired acquired JJ cord-333405-ji58jbct 247 17 and and CC cord-333405-ji58jbct 247 18 transmissible transmissible JJ cord-333405-ji58jbct 247 19 spongiform spongiform JJ cord-333405-ji58jbct 247 20 encephalopathies encephalopathy NNS cord-333405-ji58jbct 247 21 Nützliche Nützliche NNP cord-333405-ji58jbct 248 1 und und NNP cord-333405-ji58jbct 249 1 auf auf NNP cord-333405-ji58jbct 249 2 die die VBP cord-333405-ji58jbct 250 1 Erfahrung Erfahrung NNP cord-333405-ji58jbct 250 2 gegründete gegründete NNP cord-333405-ji58jbct 251 1 Einleitung Einleitung NNP cord-333405-ji58jbct 251 2 zu zu NNP cord-333405-ji58jbct 251 3 der der NNP cord-333405-ji58jbct 251 4 Landwirthschaft Landwirthschaft NNP cord-333405-ji58jbct 251 5 Identification Identification NNP cord-333405-ji58jbct 251 6 of of IN cord-333405-ji58jbct 251 7 a a DT cord-333405-ji58jbct 251 8 second second JJ cord-333405-ji58jbct 251 9 bovine bovine JJ cord-333405-ji58jbct 251 10 amyloidotic amyloidotic JJ cord-333405-ji58jbct 251 11 spongiform spongiform JJ cord-333405-ji58jbct 251 12 encephalopathy encephalopathy NN cord-333405-ji58jbct 251 13 : : : cord-333405-ji58jbct 252 1 molecular molecular JJ cord-333405-ji58jbct 252 2 similarities similarity NNS cord-333405-ji58jbct 252 3 with with IN cord-333405-ji58jbct 252 4 sporadic sporadic JJ cord-333405-ji58jbct 252 5 Creutzfeldt Creutzfeldt NNP cord-333405-ji58jbct 252 6 - - HYPH cord-333405-ji58jbct 252 7 Jakob Jakob NNP cord-333405-ji58jbct 252 8 disease disease NN cord-333405-ji58jbct 252 9 Scrapie Scrapie NNP cord-333405-ji58jbct 252 10 and and CC cord-333405-ji58jbct 252 11 chronic chronic JJ cord-333405-ji58jbct 252 12 wasting waste VBG cord-333405-ji58jbct 252 13 disease disease NN cord-333405-ji58jbct 252 14 Severe severe JJ cord-333405-ji58jbct 252 15 streptococcal streptococcal JJ cord-333405-ji58jbct 252 16 infections infection NNS cord-333405-ji58jbct 252 17 in in IN cord-333405-ji58jbct 252 18 historical historical JJ cord-333405-ji58jbct 252 19 perspective perspective NN cord-333405-ji58jbct 252 20 Emerging Emerging NNP cord-333405-ji58jbct 252 21 Infections Infections NNPS cord-333405-ji58jbct 252 22 Brazilian brazilian JJ cord-333405-ji58jbct 252 23 purpuric purpuric NN cord-333405-ji58jbct 252 24 fever fever NN cord-333405-ji58jbct 252 25 : : : cord-333405-ji58jbct 252 26 evolutionary evolutionary JJ cord-333405-ji58jbct 252 27 genetic genetic JJ cord-333405-ji58jbct 252 28 relationships relationship NNS cord-333405-ji58jbct 252 29 of of IN cord-333405-ji58jbct 252 30 the the DT cord-333405-ji58jbct 252 31 case case NN cord-333405-ji58jbct 252 32 clone clone NN cord-333405-ji58jbct 252 33 of of IN cord-333405-ji58jbct 252 34 Haemophilus Haemophilus NNP cord-333405-ji58jbct 252 35 influenzae influenzae NN cord-333405-ji58jbct 252 36 biogroup biogroup NNP cord-333405-ji58jbct 252 37 aegyptius aegyptius NN cord-333405-ji58jbct 252 38 to to IN cord-333405-ji58jbct 252 39 encapsulated encapsulate VBN cord-333405-ji58jbct 252 40 strains strain NNS cord-333405-ji58jbct 252 41 of of IN cord-333405-ji58jbct 252 42 Haemophilus haemophilus JJ cord-333405-ji58jbct 252 43 influenzae influenzae NN cord-333405-ji58jbct 252 44 Identification identification NN cord-333405-ji58jbct 252 45 and and CC cord-333405-ji58jbct 252 46 characterization characterization NN cord-333405-ji58jbct 252 47 of of IN cord-333405-ji58jbct 252 48 genomic genomic JJ cord-333405-ji58jbct 252 49 loci locus NNS cord-333405-ji58jbct 252 50 unique unique JJ cord-333405-ji58jbct 252 51 to to IN cord-333405-ji58jbct 252 52 the the DT cord-333405-ji58jbct 252 53 Brazilian brazilian JJ cord-333405-ji58jbct 252 54 purpuric purpuric NN cord-333405-ji58jbct 252 55 fever fever NN cord-333405-ji58jbct 252 56 clonal clonal JJ cord-333405-ji58jbct 252 57 group group NN cord-333405-ji58jbct 252 58 of of IN cord-333405-ji58jbct 252 59 H. H. NNP cord-333405-ji58jbct 252 60 influenzae influenzae NN cord-333405-ji58jbct 252 61 biogroup biogroup NNP cord-333405-ji58jbct 252 62 aegyptius aegyptius NNP cord-333405-ji58jbct 252 63 : : : cord-333405-ji58jbct 252 64 functionality functionality NN cord-333405-ji58jbct 252 65 explored explore VBD cord-333405-ji58jbct 252 66 using use VBG cord-333405-ji58jbct 252 67 meningococcal meningococcal JJ cord-333405-ji58jbct 252 68 homology homology NN cord-333405-ji58jbct 252 69 Group Group NNP cord-333405-ji58jbct 252 70 A a DT cord-333405-ji58jbct 252 71 streptococcus streptococcus NN cord-333405-ji58jbct 252 72 : : : cord-333405-ji58jbct 252 73 allelic allelic JJ cord-333405-ji58jbct 252 74 variation variation NN cord-333405-ji58jbct 252 75 , , , cord-333405-ji58jbct 252 76 population population NN cord-333405-ji58jbct 252 77 genetics genetics NN cord-333405-ji58jbct 252 78 , , , cord-333405-ji58jbct 252 79 and and CC cord-333405-ji58jbct 252 80 host host NN cord-333405-ji58jbct 252 81 - - HYPH cord-333405-ji58jbct 252 82 pathogen pathogen NN cord-333405-ji58jbct 252 83 interactions interaction NNS cord-333405-ji58jbct 252 84 Genome Genome NNP cord-333405-ji58jbct 252 85 sequence sequence NN cord-333405-ji58jbct 252 86 of of IN cord-333405-ji58jbct 252 87 a a DT cord-333405-ji58jbct 252 88 serotype serotype JJ cord-333405-ji58jbct 252 89 M3 m3 NN cord-333405-ji58jbct 252 90 strain strain NN cord-333405-ji58jbct 252 91 of of IN cord-333405-ji58jbct 252 92 group group NN cord-333405-ji58jbct 252 93 A a DT cord-333405-ji58jbct 252 94 Streptococcus streptococcus NN cord-333405-ji58jbct 252 95 : : : cord-333405-ji58jbct 252 96 phage phage NN cord-333405-ji58jbct 252 97 - - HYPH cord-333405-ji58jbct 252 98 encoded encode VBN cord-333405-ji58jbct 252 99 toxins toxin NNS cord-333405-ji58jbct 252 100 , , , cord-333405-ji58jbct 252 101 the the DT cord-333405-ji58jbct 252 102 high high JJ cord-333405-ji58jbct 252 103 - - HYPH cord-333405-ji58jbct 252 104 virulence virulence NN cord-333405-ji58jbct 252 105 phenotype phenotype NN cord-333405-ji58jbct 252 106 , , , cord-333405-ji58jbct 252 107 and and CC cord-333405-ji58jbct 252 108 clone clone VB cord-333405-ji58jbct 252 109 emergence emergence NN cord-333405-ji58jbct 252 110 Identification identification NN cord-333405-ji58jbct 252 111 of of IN cord-333405-ji58jbct 252 112 herpesvirus herpesvirus NN cord-333405-ji58jbct 252 113 - - HYPH cord-333405-ji58jbct 252 114 like like JJ cord-333405-ji58jbct 252 115 DNA dna NN cord-333405-ji58jbct 252 116 sequences sequence NNS cord-333405-ji58jbct 252 117 in in IN cord-333405-ji58jbct 252 118 AIDS AIDS NNP cord-333405-ji58jbct 252 119 - - HYPH cord-333405-ji58jbct 252 120 associated associate VBN cord-333405-ji58jbct 252 121 Kaposi Kaposi NNP cord-333405-ji58jbct 252 122 's 's POS cord-333405-ji58jbct 252 123 sarcoma sarcoma NN cord-333405-ji58jbct 252 124 Microbes microbe NNS cord-333405-ji58jbct 252 125 and and CC cord-333405-ji58jbct 252 126 Malignancy malignancy NN cord-333405-ji58jbct 252 127 : : : cord-333405-ji58jbct 252 128 Infection infection NN cord-333405-ji58jbct 252 129 as as IN cord-333405-ji58jbct 252 130 a a DT cord-333405-ji58jbct 252 131 Cause cause NN cord-333405-ji58jbct 252 132 of of IN cord-333405-ji58jbct 252 133 Human Human NNP cord-333405-ji58jbct 252 134 Cancers Cancers NNPS cord-333405-ji58jbct 252 135 Helicobacter Helicobacter NNP cord-333405-ji58jbct 252 136 pylori pylori NN cord-333405-ji58jbct 252 137 - - HYPH cord-333405-ji58jbct 252 138 associated associate VBN cord-333405-ji58jbct 252 139 diseases disease NNS cord-333405-ji58jbct 253 1 Current current JJ cord-333405-ji58jbct 253 2 Clinical clinical JJ cord-333405-ji58jbct 253 3 Topics topic NNS cord-333405-ji58jbct 253 4 in in IN cord-333405-ji58jbct 253 5 Infectious Infectious NNP cord-333405-ji58jbct 253 6 Diseases Diseases NNPS cord-333405-ji58jbct 253 7 Vol Vol NNP cord-333405-ji58jbct 253 8 El El NNP cord-333405-ji58jbct 253 9 Niño Niño NNP cord-333405-ji58jbct 253 10 and and CC cord-333405-ji58jbct 253 11 health health NN cord-333405-ji58jbct 253 12 Epidemiology epidemiology NN cord-333405-ji58jbct 253 13 in in IN cord-333405-ji58jbct 253 14 Relation Relation NNP cord-333405-ji58jbct 253 15 to to IN cord-333405-ji58jbct 253 16 Air Air NNP cord-333405-ji58jbct 253 17 Travel Travel NNP cord-333405-ji58jbct 253 18 Acute acute JJ cord-333405-ji58jbct 253 19 haemorrhagic haemorrhagic JJ cord-333405-ji58jbct 253 20 conjunctivitis conjunctivitis NN cord-333405-ji58jbct 253 21 : : : cord-333405-ji58jbct 253 22 dealing deal VBG cord-333405-ji58jbct 253 23 with with IN cord-333405-ji58jbct 253 24 a a DT cord-333405-ji58jbct 253 25 newly newly RB cord-333405-ji58jbct 253 26 emerging emerge VBG cord-333405-ji58jbct 253 27 disease disease NN cord-333405-ji58jbct 253 28 Two two CD cord-333405-ji58jbct 253 29 worlds world NNS cord-333405-ji58jbct 253 30 of of IN cord-333405-ji58jbct 253 31 malaria malaria NN cord-333405-ji58jbct 253 32 Research research NN cord-333405-ji58jbct 253 33 toward toward IN cord-333405-ji58jbct 253 34 vaccines vaccine NNS cord-333405-ji58jbct 253 35 against against IN cord-333405-ji58jbct 253 36 malaria malaria NN cord-333405-ji58jbct 254 1 The the DT cord-333405-ji58jbct 254 2 global global JJ cord-333405-ji58jbct 254 3 situation situation NN cord-333405-ji58jbct 254 4 of of IN cord-333405-ji58jbct 254 5 MDR MDR NNP cord-333405-ji58jbct 254 6 - - HYPH cord-333405-ji58jbct 254 7 TB TB NNP cord-333405-ji58jbct 254 8 Staphylococcus Staphylococcus NNP cord-333405-ji58jbct 254 9 aureus aureu NNS cord-333405-ji58jbct 254 10 resistant resistant JJ cord-333405-ji58jbct 254 11 to to IN cord-333405-ji58jbct 254 12 vancomycin vancomycin FW cord-333405-ji58jbct 254 13 -United -unite VBN cord-333405-ji58jbct 255 1 States state NNS cord-333405-ji58jbct 255 2 Methicillin Methicillin NNP cord-333405-ji58jbct 255 3 ( ( -LRB- cord-333405-ji58jbct 255 4 oxacillin)-resistant oxacillin)-resistant NNP cord-333405-ji58jbct 255 5 Staphylococcus Staphylococcus NNP cord-333405-ji58jbct 255 6 aureus aureus NN cord-333405-ji58jbct 255 7 strains strain NNS cord-333405-ji58jbct 255 8 isolated isolate VBN cord-333405-ji58jbct 255 9 from from IN cord-333405-ji58jbct 255 10 major major JJ cord-333405-ji58jbct 255 11 food food NN cord-333405-ji58jbct 255 12 animals animal NNS cord-333405-ji58jbct 255 13 and and CC cord-333405-ji58jbct 255 14 their -PRON- PRP$ cord-333405-ji58jbct 255 15 potential potential JJ cord-333405-ji58jbct 255 16 transmission transmission NN cord-333405-ji58jbct 255 17 to to IN cord-333405-ji58jbct 255 18 humans human NNS cord-333405-ji58jbct 256 1 The the DT cord-333405-ji58jbct 256 2 crisis crisis NN cord-333405-ji58jbct 256 3 in in IN cord-333405-ji58jbct 256 4 antibiotic antibiotic JJ cord-333405-ji58jbct 256 5 resistance resistance NN cord-333405-ji58jbct 256 6 Surveillance surveillance NN cord-333405-ji58jbct 256 7 for for IN cord-333405-ji58jbct 256 8 AIDS AIDS NNP cord-333405-ji58jbct 256 9 - - HYPH cord-333405-ji58jbct 256 10 defining define VBG cord-333405-ji58jbct 256 11 opportunistic opportunistic JJ cord-333405-ji58jbct 256 12 illnesses illness NNS cord-333405-ji58jbct 256 13 , , , cord-333405-ji58jbct 256 14 1992 1992 CD cord-333405-ji58jbct 256 15 - - SYM cord-333405-ji58jbct 256 16 1997 1997 CD cord-333405-ji58jbct 256 17 . . . cord-333405-ji58jbct 257 1 MMWR MMWR NNP cord-333405-ji58jbct 257 2 48 48 CD cord-333405-ji58jbct 258 1 ( ( -LRB- cord-333405-ji58jbct 258 2 CDC CDC NNP cord-333405-ji58jbct 258 3 Surveillance Surveillance NNP cord-333405-ji58jbct 258 4 Summary Summary NNP cord-333405-ji58jbct 258 5 no no NN cord-333405-ji58jbct 258 6 . . . cord-333405-ji58jbct 259 1 SS-2 SS-2 NNP cord-333405-ji58jbct 259 2 ) ) -RRB- cord-333405-ji58jbct 259 3 Infections infection NNS cord-333405-ji58jbct 259 4 in in IN cord-333405-ji58jbct 259 5 patients patient NNS cord-333405-ji58jbct 259 6 with with IN cord-333405-ji58jbct 259 7 cancer cancer NN cord-333405-ji58jbct 259 8 undergoing undergo VBG cord-333405-ji58jbct 259 9 chemotherapy chemotherapy NN cord-333405-ji58jbct 259 10 : : : cord-333405-ji58jbct 259 11 aetiology aetiology NN cord-333405-ji58jbct 259 12 , , , cord-333405-ji58jbct 259 13 prevention prevention NN cord-333405-ji58jbct 259 14 , , , cord-333405-ji58jbct 259 15 and and CC cord-333405-ji58jbct 259 16 treatment treatment NN cord-333405-ji58jbct 259 17 Impact impact NN cord-333405-ji58jbct 259 18 of of IN cord-333405-ji58jbct 259 19 current current JJ cord-333405-ji58jbct 259 20 transplantation transplantation NN cord-333405-ji58jbct 259 21 practices practice NNS cord-333405-ji58jbct 259 22 on on IN cord-333405-ji58jbct 259 23 the the DT cord-333405-ji58jbct 259 24 changing change VBG cord-333405-ji58jbct 259 25 epidemiology epidemiology NN cord-333405-ji58jbct 259 26 of of IN cord-333405-ji58jbct 259 27 infections infection NNS cord-333405-ji58jbct 259 28 in in IN cord-333405-ji58jbct 259 29 transplant transplant NN cord-333405-ji58jbct 259 30 recipients recipient NNS cord-333405-ji58jbct 259 31 Xenotransplantation Xenotransplantation NNP cord-333405-ji58jbct 259 32 : : : cord-333405-ji58jbct 259 33 public public JJ cord-333405-ji58jbct 259 34 health health NN cord-333405-ji58jbct 259 35 risks risk NNS cord-333405-ji58jbct 259 36 -patient -patient . cord-333405-ji58jbct 260 1 vs. vs. IN cord-333405-ji58jbct 260 2 society society NN cord-333405-ji58jbct 260 3 in in IN cord-333405-ji58jbct 260 4 an an DT cord-333405-ji58jbct 260 5 emerging emerge VBG cord-333405-ji58jbct 260 6 field field NN cord-333405-ji58jbct 261 1 The the DT cord-333405-ji58jbct 261 2 outbreak outbreak NN cord-333405-ji58jbct 261 3 of of IN cord-333405-ji58jbct 261 4 West West NNP cord-333405-ji58jbct 261 5 Nile Nile NNP cord-333405-ji58jbct 261 6 virus virus NN cord-333405-ji58jbct 261 7 infection infection NN cord-333405-ji58jbct 261 8 in in IN cord-333405-ji58jbct 261 9 the the DT cord-333405-ji58jbct 261 10 New New NNP cord-333405-ji58jbct 261 11 York York NNP cord-333405-ji58jbct 261 12 City City NNP cord-333405-ji58jbct 261 13 area area NN cord-333405-ji58jbct 261 14 in in IN cord-333405-ji58jbct 261 15 1999 1999 CD cord-333405-ji58jbct 261 16 Outbreak outbreak NN cord-333405-ji58jbct 261 17 of of IN cord-333405-ji58jbct 261 18 West West NNP cord-333405-ji58jbct 261 19 Nile Nile NNP cord-333405-ji58jbct 261 20 infection infection NN cord-333405-ji58jbct 261 21 West West NNP cord-333405-ji58jbct 261 22 Nile Nile NNP cord-333405-ji58jbct 261 23 virus virus NN cord-333405-ji58jbct 261 24 : : : cord-333405-ji58jbct 261 25 epidemiology epidemiology NN cord-333405-ji58jbct 261 26 and and CC cord-333405-ji58jbct 261 27 ecology ecology NN cord-333405-ji58jbct 261 28 in in IN cord-333405-ji58jbct 261 29 North North NNP cord-333405-ji58jbct 261 30 America America NNP cord-333405-ji58jbct 261 31 Dengue Dengue NNP cord-333405-ji58jbct 261 32 and and CC cord-333405-ji58jbct 261 33 dengue dengue NN cord-333405-ji58jbct 261 34 haemorrhagic haemorrhagic JJ cord-333405-ji58jbct 261 35 fever fever NN cord-333405-ji58jbct 261 36 Antibody antibody NN cord-333405-ji58jbct 261 37 - - HYPH cord-333405-ji58jbct 261 38 dependent dependent JJ cord-333405-ji58jbct 261 39 enhancement enhancement NN cord-333405-ji58jbct 261 40 of of IN cord-333405-ji58jbct 261 41 infection infection NN cord-333405-ji58jbct 261 42 and and CC cord-333405-ji58jbct 261 43 the the DT cord-333405-ji58jbct 261 44 pathogenesis pathogenesis NN cord-333405-ji58jbct 261 45 of of IN cord-333405-ji58jbct 261 46 viral viral JJ cord-333405-ji58jbct 261 47 disease disease NN cord-333405-ji58jbct 261 48 Molecular molecular JJ cord-333405-ji58jbct 261 49 ecology ecology NN cord-333405-ji58jbct 261 50 of of IN cord-333405-ji58jbct 261 51 toxigenic toxigenic JJ cord-333405-ji58jbct 261 52 Vibrio Vibrio NNP cord-333405-ji58jbct 261 53 cholerae cholerae NN cord-333405-ji58jbct 262 1 The the DT cord-333405-ji58jbct 262 2 next next JJ cord-333405-ji58jbct 262 3 influenza influenza NN cord-333405-ji58jbct 262 4 pandemic pandemic NN cord-333405-ji58jbct 262 5 : : : cord-333405-ji58jbct 262 6 lessons lesson NNS cord-333405-ji58jbct 262 7 from from IN cord-333405-ji58jbct 262 8 Hong Hong NNP cord-333405-ji58jbct 262 9 Kong Kong NNP cord-333405-ji58jbct 263 1 A a DT cord-333405-ji58jbct 263 2 molecular molecular JJ cord-333405-ji58jbct 263 3 whodunit whodunit NN cord-333405-ji58jbct 263 4 Avian avian JJ cord-333405-ji58jbct 263 5 influenza influenza NN cord-333405-ji58jbct 263 6 viruses virus NNS cord-333405-ji58jbct 263 7 infecting infect VBG cord-333405-ji58jbct 263 8 humans human NNS cord-333405-ji58jbct 263 9 Structure Structure NNP cord-333405-ji58jbct 263 10 of of IN cord-333405-ji58jbct 263 11 the the DT cord-333405-ji58jbct 263 12 uncleaved uncleaved JJ cord-333405-ji58jbct 263 13 human human NNP cord-333405-ji58jbct 263 14 H1 H1 NNP cord-333405-ji58jbct 263 15 haemagglutinin haemagglutinin NNP cord-333405-ji58jbct 263 16 from from IN cord-333405-ji58jbct 263 17 the the DT cord-333405-ji58jbct 263 18 extinct extinct JJ cord-333405-ji58jbct 263 19 1918 1918 CD cord-333405-ji58jbct 263 20 influenza influenza NN cord-333405-ji58jbct 263 21 virus virus NN cord-333405-ji58jbct 264 1 The the DT cord-333405-ji58jbct 264 2 origin origin NN cord-333405-ji58jbct 264 3 of of IN cord-333405-ji58jbct 264 4 the the DT cord-333405-ji58jbct 264 5 1918 1918 CD cord-333405-ji58jbct 264 6 pandemic pandemic NNP cord-333405-ji58jbct 264 7 influenza influenza NN cord-333405-ji58jbct 264 8 virus virus NN cord-333405-ji58jbct 264 9 : : : cord-333405-ji58jbct 264 10 a a DT cord-333405-ji58jbct 264 11 continuing continue VBG cord-333405-ji58jbct 264 12 enigma enigma NN cord-333405-ji58jbct 264 13 Potential potential JJ cord-333405-ji58jbct 264 14 impact impact NN cord-333405-ji58jbct 264 15 of of IN cord-333405-ji58jbct 264 16 low low JJ cord-333405-ji58jbct 264 17 - - HYPH cord-333405-ji58jbct 264 18 efficacy efficacy NN cord-333405-ji58jbct 264 19 HIV-1 HIV-1 NNP cord-333405-ji58jbct 264 20 vaccines vaccine NNS cord-333405-ji58jbct 264 21 in in IN cord-333405-ji58jbct 264 22 populations population NNS cord-333405-ji58jbct 264 23 with with IN cord-333405-ji58jbct 264 24 high high JJ cord-333405-ji58jbct 264 25 rates rate NNS cord-333405-ji58jbct 264 26 of of IN cord-333405-ji58jbct 264 27 infection infection NN cord-333405-ji58jbct 264 28 Short short JJ cord-333405-ji58jbct 264 29 - - HYPH cord-333405-ji58jbct 264 30 term term NN cord-333405-ji58jbct 264 31 projections projection NNS cord-333405-ji58jbct 264 32 for for IN cord-333405-ji58jbct 264 33 variant variant JJ cord-333405-ji58jbct 264 34 Creutzfeldt Creutzfeldt NNP cord-333405-ji58jbct 264 35 - - HYPH cord-333405-ji58jbct 264 36 Jakob Jakob NNP cord-333405-ji58jbct 264 37 disease disease NN cord-333405-ji58jbct 264 38 onsets onset NNS cord-333405-ji58jbct 264 39 Mortality mortality NN cord-333405-ji58jbct 264 40 associated associate VBN cord-333405-ji58jbct 264 41 with with IN cord-333405-ji58jbct 264 42 influenza influenza NN cord-333405-ji58jbct 264 43 and and CC cord-333405-ji58jbct 264 44 respiratory respiratory JJ cord-333405-ji58jbct 264 45 syncytial syncytial JJ cord-333405-ji58jbct 264 46 virus virus NN cord-333405-ji58jbct 264 47 in in IN cord-333405-ji58jbct 264 48 the the DT cord-333405-ji58jbct 264 49 United United NNP cord-333405-ji58jbct 264 50 States States NNP cord-333405-ji58jbct 265 1 The the DT cord-333405-ji58jbct 265 2 Chilling Chilling NNP cord-333405-ji58jbct 265 3 True True NNP cord-333405-ji58jbct 265 4 Story Story NNP cord-333405-ji58jbct 265 5 of of IN cord-333405-ji58jbct 265 6 the the DT cord-333405-ji58jbct 265 7 Largest large JJS cord-333405-ji58jbct 265 8 Covert Covert NNP cord-333405-ji58jbct 265 9 Biological Biological NNP cord-333405-ji58jbct 265 10 Weapons Weapons NNPS cord-333405-ji58jbct 265 11 Program Program NNP cord-333405-ji58jbct 265 12 in in IN cord-333405-ji58jbct 265 13 the the DT cord-333405-ji58jbct 265 14 World World NNP cord-333405-ji58jbct 265 15 -Told -Told NNP cord-333405-ji58jbct 266 1 From from IN cord-333405-ji58jbct 266 2 the the DT cord-333405-ji58jbct 266 3 Inside Inside NNP cord-333405-ji58jbct 266 4 by by IN cord-333405-ji58jbct 266 5 the the DT cord-333405-ji58jbct 266 6 Man man NN cord-333405-ji58jbct 266 7 Who who WP cord-333405-ji58jbct 266 8 Ran run VBD cord-333405-ji58jbct 266 9 It -PRON- PRP cord-333405-ji58jbct 266 10 ( ( -LRB- cord-333405-ji58jbct 266 11 Random Random NNP cord-333405-ji58jbct 266 12 House House NNP cord-333405-ji58jbct 266 13 Document Document NNP cord-333405-ji58jbct 266 14 zur zur NNP cord-333405-ji58jbct 266 15 Geschichte Geschichte NNP cord-333405-ji58jbct 266 16 des des FW cord-333405-ji58jbct 266 17 schwarzen schwarzen VBN cord-333405-ji58jbct 266 18 Todes Todes NNP cord-333405-ji58jbct 266 19 . . . cord-333405-ji58jbct 267 1 Mitgetheilt Mitgetheilt NNP cord-333405-ji58jbct 267 2 und und IN cord-333405-ji58jbct 267 3 eingeleitet eingeleitet NNP cord-333405-ji58jbct 267 4 Smallpox Smallpox NNP cord-333405-ji58jbct 267 5 and and CC cord-333405-ji58jbct 267 6 the the DT cord-333405-ji58jbct 267 7 Indians Indians NNPS cord-333405-ji58jbct 267 8 in in IN cord-333405-ji58jbct 267 9 the the DT cord-333405-ji58jbct 267 10 American american JJ cord-333405-ji58jbct 267 11 colonies colony NNS cord-333405-ji58jbct 268 1 A a DT cord-333405-ji58jbct 268 2 large large JJ cord-333405-ji58jbct 268 3 community community NN cord-333405-ji58jbct 268 4 outbreak outbreak NN cord-333405-ji58jbct 268 5 of of IN cord-333405-ji58jbct 268 6 salmonellosis salmonellosis NN cord-333405-ji58jbct 268 7 caused cause VBN cord-333405-ji58jbct 268 8 by by IN cord-333405-ji58jbct 268 9 intentional intentional JJ cord-333405-ji58jbct 268 10 contamination contamination NN cord-333405-ji58jbct 268 11 of of IN cord-333405-ji58jbct 268 12 restaurant restaurant NN cord-333405-ji58jbct 268 13 salad salad NN cord-333405-ji58jbct 268 14 bars bar NNS cord-333405-ji58jbct 269 1 Biodefence Biodefence NNP cord-333405-ji58jbct 269 2 on on IN cord-333405-ji58jbct 269 3 the the DT cord-333405-ji58jbct 269 4 research research NN cord-333405-ji58jbct 269 5 agenda agenda NN cord-333405-ji58jbct 270 1 : : : cord-333405-ji58jbct 270 2 the the DT cord-333405-ji58jbct 270 3 world world NN cord-333405-ji58jbct 270 4 needs need VBZ cord-333405-ji58jbct 270 5 new new JJ cord-333405-ji58jbct 270 6 and and CC cord-333405-ji58jbct 270 7 creative creative JJ cord-333405-ji58jbct 270 8 ways way NNS cord-333405-ji58jbct 270 9 to to TO cord-333405-ji58jbct 270 10 counter counter VB cord-333405-ji58jbct 270 11 bioterrorism bioterrorism NN cord-333405-ji58jbct 270 12 Threats threat NNS cord-333405-ji58jbct 270 13 in in IN cord-333405-ji58jbct 270 14 bioterrorism bioterrorism NN cord-333405-ji58jbct 270 15 : : : cord-333405-ji58jbct 271 1 I. I. NNP cord-333405-ji58jbct 271 2 CDC CDC NNP cord-333405-ji58jbct 271 3 category category NN cord-333405-ji58jbct 271 4 A a DT cord-333405-ji58jbct 271 5 agents agent NNS cord-333405-ji58jbct 271 6 World World NNP cord-333405-ji58jbct 271 7 Health Health NNP cord-333405-ji58jbct 271 8 Organization Organization NNP cord-333405-ji58jbct 271 9 . . . cord-333405-ji58jbct 272 1 Consensus Consensus NNP cord-333405-ji58jbct 272 2 Document Document NNP cord-333405-ji58jbct 272 3 on on IN cord-333405-ji58jbct 272 4 the the DT cord-333405-ji58jbct 272 5 Epidemiology Epidemiology NNP cord-333405-ji58jbct 272 6 of of IN cord-333405-ji58jbct 272 7 Severe severe JJ cord-333405-ji58jbct 272 8 Acute acute JJ cord-333405-ji58jbct 272 9 Respiratory Respiratory NNP cord-333405-ji58jbct 272 10 Syndrome Syndrome NNP cord-333405-ji58jbct 272 11 ( ( -LRB- cord-333405-ji58jbct 272 12 SARS SARS NNP cord-333405-ji58jbct 272 13 ) ) -RRB- cord-333405-ji58jbct 273 1 Preventing prevent VBG cord-333405-ji58jbct 273 2 Emerging emerge VBG cord-333405-ji58jbct 273 3 Infectious Infectious NNP cord-333405-ji58jbct 273 4 Diseases Diseases NNPS cord-333405-ji58jbct 273 5 : : : cord-333405-ji58jbct 274 1 A a DT cord-333405-ji58jbct 274 2 Strategy Strategy NNP cord-333405-ji58jbct 274 3 for for IN cord-333405-ji58jbct 274 4 the the DT cord-333405-ji58jbct 274 5 21st 21st JJ cord-333405-ji58jbct 274 6 Century Century NNP cord-333405-ji58jbct 274 7 ( ( -LRB- cord-333405-ji58jbct 274 8 Department Department NNP cord-333405-ji58jbct 274 9 of of IN cord-333405-ji58jbct 274 10 Health Health NNP cord-333405-ji58jbct 274 11 and and CC cord-333405-ji58jbct 274 12 Human Human NNP cord-333405-ji58jbct 274 13 Services Services NNPS cord-333405-ji58jbct 274 14 Protein Protein NNP cord-333405-ji58jbct 274 15 structure structure NN cord-333405-ji58jbct 274 16 prediction prediction NN cord-333405-ji58jbct 274 17 and and CC cord-333405-ji58jbct 274 18 structural structural JJ cord-333405-ji58jbct 274 19 genomics genomic NNS cord-333405-ji58jbct 274 20 Guidelines guideline NNS cord-333405-ji58jbct 274 21 for for IN cord-333405-ji58jbct 274 22 using use VBG cord-333405-ji58jbct 274 23 antiretroviral antiretroviral JJ cord-333405-ji58jbct 274 24 agents agent NNS cord-333405-ji58jbct 274 25 among among IN cord-333405-ji58jbct 274 26 HIV HIV NNP cord-333405-ji58jbct 274 27 - - HYPH cord-333405-ji58jbct 274 28 infected infect VBN cord-333405-ji58jbct 274 29 adults adult NNS cord-333405-ji58jbct 274 30 and and CC cord-333405-ji58jbct 274 31 adolescents adolescent NNS cord-333405-ji58jbct 274 32 New new JJ cord-333405-ji58jbct 274 33 technology technology NN cord-333405-ji58jbct 274 34 platforms platform NNS cord-333405-ji58jbct 274 35 in in IN cord-333405-ji58jbct 274 36 the the DT cord-333405-ji58jbct 274 37 development development NN cord-333405-ji58jbct 274 38 of of IN cord-333405-ji58jbct 274 39 vaccines vaccine NNS cord-333405-ji58jbct 274 40 for for IN cord-333405-ji58jbct 274 41 the the DT cord-333405-ji58jbct 274 42 future future NN cord-333405-ji58jbct 275 1 The the DT cord-333405-ji58jbct 275 2 Jordan Jordan NNP cord-333405-ji58jbct 275 3 Report Report NNP cord-333405-ji58jbct 275 4 : : : cord-333405-ji58jbct 275 5 20th 20th JJ cord-333405-ji58jbct 275 6 Anniversary Anniversary NNP cord-333405-ji58jbct 275 7 Adjuvants adjuvant NNS cord-333405-ji58jbct 275 8 of of IN cord-333405-ji58jbct 275 9 immunity immunity NN cord-333405-ji58jbct 275 10 : : : cord-333405-ji58jbct 275 11 harnessing harness VBG cord-333405-ji58jbct 275 12 innate innate JJ cord-333405-ji58jbct 275 13 immunity immunity NN cord-333405-ji58jbct 275 14 to to TO cord-333405-ji58jbct 275 15 promote promote VB cord-333405-ji58jbct 275 16 adaptive adaptive JJ cord-333405-ji58jbct 275 17 immunity immunity NN cord-333405-ji58jbct 276 1 Recent recent JJ cord-333405-ji58jbct 276 2 advances advance NNS cord-333405-ji58jbct 276 3 in in IN cord-333405-ji58jbct 276 4 the the DT cord-333405-ji58jbct 276 5 discovery discovery NN cord-333405-ji58jbct 276 6 and and CC cord-333405-ji58jbct 276 7 delivery delivery NN cord-333405-ji58jbct 276 8 of of IN cord-333405-ji58jbct 276 9 vaccine vaccine NN cord-333405-ji58jbct 276 10 adjuvants adjuvant NNS cord-333405-ji58jbct 277 1 The the DT cord-333405-ji58jbct 277 2 value value NN cord-333405-ji58jbct 277 3 of of IN cord-333405-ji58jbct 277 4 complete complete JJ cord-333405-ji58jbct 277 5 microbial microbial JJ cord-333405-ji58jbct 277 6 genome genome NN cord-333405-ji58jbct 277 7 sequencing sequencing NN cord-333405-ji58jbct 277 8 ( ( -LRB- cord-333405-ji58jbct 277 9 you -PRON- PRP cord-333405-ji58jbct 277 10 get get VBP cord-333405-ji58jbct 277 11 what what WP cord-333405-ji58jbct 277 12 you -PRON- PRP cord-333405-ji58jbct 277 13 pay pay VBP cord-333405-ji58jbct 277 14 for for IN cord-333405-ji58jbct 277 15 ) ) -RRB- cord-333405-ji58jbct 278 1 The the DT cord-333405-ji58jbct 278 2 authors author NNS cord-333405-ji58jbct 278 3 thank thank VBP cord-333405-ji58jbct 278 4 R. R. NNP cord-333405-ji58jbct 278 5 M. M. NNP cord-333405-ji58jbct 278 6 Krause Krause NNP cord-333405-ji58jbct 278 7 for for IN cord-333405-ji58jbct 278 8 helpful helpful JJ cord-333405-ji58jbct 278 9 discussions discussion NNS cord-333405-ji58jbct 278 10 , , , cord-333405-ji58jbct 278 11 and and CC cord-333405-ji58jbct 278 12 J. J. NNP cord-333405-ji58jbct 278 13 Weddle Weddle NNP cord-333405-ji58jbct 278 14 for for IN cord-333405-ji58jbct 278 15 graphic graphic JJ cord-333405-ji58jbct 278 16 design design NN cord-333405-ji58jbct 278 17 . . . cord-333405-ji58jbct 279 1 The the DT cord-333405-ji58jbct 279 2 authors author NNS cord-333405-ji58jbct 279 3 declare declare VBP cord-333405-ji58jbct 279 4 that that IN cord-333405-ji58jbct 279 5 they -PRON- PRP cord-333405-ji58jbct 279 6 have have VBP cord-333405-ji58jbct 279 7 no no DT cord-333405-ji58jbct 279 8 competing compete VBG cord-333405-ji58jbct 279 9 financial financial JJ cord-333405-ji58jbct 279 10 interests.insight interests.insight NNP cord-333405-ji58jbct 279 11 review review NN cord-333405-ji58jbct 279 12 articles article NNS