id sid tid token lemma pos cord-303447-3a7jxl34 1 1 key key JJ cord-303447-3a7jxl34 1 2 : : : cord-303447-3a7jxl34 1 3 cord-303447 cord-303447 XX cord-303447-3a7jxl34 1 4 - - HYPH cord-303447-3a7jxl34 1 5 3a7jxl34 3a7jxl34 CD cord-303447-3a7jxl34 1 6 authors author NNS cord-303447-3a7jxl34 1 7 : : : cord-303447-3a7jxl34 1 8 Cohn Cohn NNP cord-303447-3a7jxl34 1 9 , , , cord-303447-3a7jxl34 1 10 Amanda Amanda NNP cord-303447-3a7jxl34 1 11 C. C. NNP cord-303447-3a7jxl34 1 12 ; ; : cord-303447-3a7jxl34 1 13 Broder Broder NNP cord-303447-3a7jxl34 1 14 , , , cord-303447-3a7jxl34 1 15 Karen Karen NNP cord-303447-3a7jxl34 1 16 R. R. NNP cord-303447-3a7jxl34 1 17 ; ; : cord-303447-3a7jxl34 1 18 Pickering Pickering NNP cord-303447-3a7jxl34 1 19 , , , cord-303447-3a7jxl34 1 20 Larry Larry NNP cord-303447-3a7jxl34 1 21 K. K. NNP cord-303447-3a7jxl34 1 22 title title NN cord-303447-3a7jxl34 1 23 : : : cord-303447-3a7jxl34 1 24 Immunizations immunization NNS cord-303447-3a7jxl34 1 25 in in IN cord-303447-3a7jxl34 1 26 the the DT cord-303447-3a7jxl34 1 27 United United NNP cord-303447-3a7jxl34 1 28 States States NNP cord-303447-3a7jxl34 1 29 : : : cord-303447-3a7jxl34 1 30 A a DT cord-303447-3a7jxl34 1 31 Rite rite NN cord-303447-3a7jxl34 1 32 of of IN cord-303447-3a7jxl34 1 33 Passage passage NN cord-303447-3a7jxl34 1 34 date date NN cord-303447-3a7jxl34 1 35 : : : cord-303447-3a7jxl34 1 36 2005 2005 CD cord-303447-3a7jxl34 1 37 - - HYPH cord-303447-3a7jxl34 1 38 05 05 CD cord-303447-3a7jxl34 1 39 - - HYPH cord-303447-3a7jxl34 1 40 28 28 CD cord-303447-3a7jxl34 1 41 journal journal NN cord-303447-3a7jxl34 1 42 : : : cord-303447-3a7jxl34 1 43 Pediatr Pediatr NNP cord-303447-3a7jxl34 1 44 Clin Clin NNP cord-303447-3a7jxl34 1 45 North North NNP cord-303447-3a7jxl34 2 1 Am Am NNP cord-303447-3a7jxl34 2 2 DOI DOI NNP cord-303447-3a7jxl34 2 3 : : : cord-303447-3a7jxl34 2 4 10.1016 10.1016 CD cord-303447-3a7jxl34 2 5 / / SYM cord-303447-3a7jxl34 2 6 j.pcl.2005.03.001 j.pcl.2005.03.001 NNP cord-303447-3a7jxl34 2 7 sha sha NNP cord-303447-3a7jxl34 2 8 : : : cord-303447-3a7jxl34 2 9 4f673458ff8e464dab793d271b770820e4540ee3 4f673458ff8e464dab793d271b770820e4540ee3 CD cord-303447-3a7jxl34 2 10 doc_id doc_id CD cord-303447-3a7jxl34 2 11 : : : cord-303447-3a7jxl34 2 12 303447 303447 CD cord-303447-3a7jxl34 2 13 cord_uid cord_uid NNS cord-303447-3a7jxl34 2 14 : : : cord-303447-3a7jxl34 3 1 3a7jxl34 3a7jxl34 CD cord-303447-3a7jxl34 4 1 Today today NN cord-303447-3a7jxl34 4 2 , , , cord-303447-3a7jxl34 4 3 vaccination vaccination NN cord-303447-3a7jxl34 4 4 is be VBZ cord-303447-3a7jxl34 4 5 a a DT cord-303447-3a7jxl34 4 6 cornerstone cornerstone NN cord-303447-3a7jxl34 4 7 of of IN cord-303447-3a7jxl34 4 8 pediatric pediatric JJ cord-303447-3a7jxl34 4 9 preventive preventive JJ cord-303447-3a7jxl34 4 10 health health NN cord-303447-3a7jxl34 4 11 care care NN cord-303447-3a7jxl34 4 12 and and CC cord-303447-3a7jxl34 4 13 a a DT cord-303447-3a7jxl34 4 14 rite rite NN cord-303447-3a7jxl34 4 15 of of IN cord-303447-3a7jxl34 4 16 passage passage NN cord-303447-3a7jxl34 4 17 for for IN cord-303447-3a7jxl34 4 18 nearly nearly RB cord-303447-3a7jxl34 4 19 all all DT cord-303447-3a7jxl34 4 20 of of IN cord-303447-3a7jxl34 4 21 the the DT cord-303447-3a7jxl34 4 22 approximately approximately RB cord-303447-3a7jxl34 4 23 11,000 11,000 CD cord-303447-3a7jxl34 4 24 infants infant NNS cord-303447-3a7jxl34 4 25 born bear VBN cord-303447-3a7jxl34 4 26 daily daily RB cord-303447-3a7jxl34 4 27 in in IN cord-303447-3a7jxl34 4 28 the the DT cord-303447-3a7jxl34 4 29 United United NNP cord-303447-3a7jxl34 4 30 States States NNP cord-303447-3a7jxl34 4 31 . . . cord-303447-3a7jxl34 5 1 This this DT cord-303447-3a7jxl34 5 2 article article NN cord-303447-3a7jxl34 5 3 reviews review VBZ cord-303447-3a7jxl34 5 4 the the DT cord-303447-3a7jxl34 5 5 US US NNP cord-303447-3a7jxl34 5 6 immunization immunization NN cord-303447-3a7jxl34 5 7 program program NN cord-303447-3a7jxl34 5 8 with with IN cord-303447-3a7jxl34 5 9 an an DT cord-303447-3a7jxl34 5 10 emphasis emphasis NN cord-303447-3a7jxl34 5 11 on on IN cord-303447-3a7jxl34 5 12 its -PRON- PRP$ cord-303447-3a7jxl34 5 13 role role NN cord-303447-3a7jxl34 5 14 in in IN cord-303447-3a7jxl34 5 15 ensuring ensure VBG cord-303447-3a7jxl34 5 16 that that IN cord-303447-3a7jxl34 5 17 vaccines vaccine NNS cord-303447-3a7jxl34 5 18 are be VBP cord-303447-3a7jxl34 5 19 effective effective JJ cord-303447-3a7jxl34 5 20 , , , cord-303447-3a7jxl34 5 21 safe safe JJ cord-303447-3a7jxl34 5 22 , , , cord-303447-3a7jxl34 5 23 and and CC cord-303447-3a7jxl34 5 24 available available JJ cord-303447-3a7jxl34 5 25 and and CC cord-303447-3a7jxl34 5 26 highlights highlight VBZ cord-303447-3a7jxl34 5 27 several several JJ cord-303447-3a7jxl34 5 28 new new JJ cord-303447-3a7jxl34 5 29 vaccines vaccine NNS cord-303447-3a7jxl34 5 30 and and CC cord-303447-3a7jxl34 5 31 recommendations recommendation NNS cord-303447-3a7jxl34 5 32 that that WDT cord-303447-3a7jxl34 5 33 will will MD cord-303447-3a7jxl34 5 34 affect affect VB cord-303447-3a7jxl34 5 35 the the DT cord-303447-3a7jxl34 5 36 health health NN cord-303447-3a7jxl34 5 37 of of IN cord-303447-3a7jxl34 5 38 children child NNS cord-303447-3a7jxl34 5 39 and and CC cord-303447-3a7jxl34 5 40 adolescents adolescent NNS cord-303447-3a7jxl34 5 41 and and CC cord-303447-3a7jxl34 5 42 the the DT cord-303447-3a7jxl34 5 43 practice practice NN cord-303447-3a7jxl34 5 44 of of IN cord-303447-3a7jxl34 5 45 pediatric pediatric JJ cord-303447-3a7jxl34 5 46 medicine medicine NN cord-303447-3a7jxl34 5 47 in in IN cord-303447-3a7jxl34 5 48 future future JJ cord-303447-3a7jxl34 5 49 decades decade NNS cord-303447-3a7jxl34 5 50 . . . cord-303447-3a7jxl34 6 1 We -PRON- PRP cord-303447-3a7jxl34 6 2 must must MD cord-303447-3a7jxl34 6 3 plan plan VB cord-303447-3a7jxl34 6 4 for for IN cord-303447-3a7jxl34 6 5 the the DT cord-303447-3a7jxl34 6 6 future future NN cord-303447-3a7jxl34 6 7 , , , cord-303447-3a7jxl34 6 8 because because IN cord-303447-3a7jxl34 6 9 people people NNS cord-303447-3a7jxl34 6 10 who who WP cord-303447-3a7jxl34 6 11 stay stay VBP cord-303447-3a7jxl34 6 12 in in IN cord-303447-3a7jxl34 6 13 the the DT cord-303447-3a7jxl34 6 14 present present NN cord-303447-3a7jxl34 6 15 will will MD cord-303447-3a7jxl34 6 16 remain remain VB cord-303447-3a7jxl34 6 17 in in IN cord-303447-3a7jxl34 6 18 the the DT cord-303447-3a7jxl34 6 19 past past NN cord-303447-3a7jxl34 6 20 . . . cord-303447-3a7jxl34 7 1 -Abraham -Abraham : cord-303447-3a7jxl34 8 1 Lincoln Lincoln NNP cord-303447-3a7jxl34 9 1 In in IN cord-303447-3a7jxl34 9 2 1796 1796 CD cord-303447-3a7jxl34 9 3 , , , cord-303447-3a7jxl34 9 4 when when WRB cord-303447-3a7jxl34 9 5 Jenner Jenner NNP cord-303447-3a7jxl34 9 6 showed show VBD cord-303447-3a7jxl34 9 7 successful successful JJ cord-303447-3a7jxl34 9 8 inoculation inoculation NN cord-303447-3a7jxl34 9 9 of of IN cord-303447-3a7jxl34 9 10 humans human NNS cord-303447-3a7jxl34 9 11 with with IN cord-303447-3a7jxl34 9 12 cowpox cowpox NN cord-303447-3a7jxl34 9 13 to to TO cord-303447-3a7jxl34 9 14 protect protect VB cord-303447-3a7jxl34 9 15 them -PRON- PRP cord-303447-3a7jxl34 9 16 from from IN cord-303447-3a7jxl34 9 17 the the DT cord-303447-3a7jxl34 9 18 devastation devastation NN cord-303447-3a7jxl34 9 19 of of IN cord-303447-3a7jxl34 9 20 smallpox smallpox NN cord-303447-3a7jxl34 9 21 , , , cord-303447-3a7jxl34 9 22 a a DT cord-303447-3a7jxl34 9 23 revolution revolution NN cord-303447-3a7jxl34 9 24 in in IN cord-303447-3a7jxl34 9 25 science science NN cord-303447-3a7jxl34 9 26 and and CC cord-303447-3a7jxl34 9 27 medicine medicine NN cord-303447-3a7jxl34 9 28 began begin VBD cord-303447-3a7jxl34 9 29 [ [ -LRB- cord-303447-3a7jxl34 9 30 1 1 CD cord-303447-3a7jxl34 9 31 ] ] -RRB- cord-303447-3a7jxl34 9 32 . . . cord-303447-3a7jxl34 10 1 More More JJR cord-303447-3a7jxl34 10 2 than than IN cord-303447-3a7jxl34 10 3 2 2 CD cord-303447-3a7jxl34 10 4 centuries century NNS cord-303447-3a7jxl34 10 5 later later RB cord-303447-3a7jxl34 10 6 , , , cord-303447-3a7jxl34 10 7 immunizations immunization NNS cord-303447-3a7jxl34 10 8 were be VBD cord-303447-3a7jxl34 10 9 hailed hail VBN cord-303447-3a7jxl34 10 10 as as IN cord-303447-3a7jxl34 10 11 one one CD cord-303447-3a7jxl34 10 12 of of IN cord-303447-3a7jxl34 10 13 ' ' '' cord-303447-3a7jxl34 10 14 ' ' '' cord-303447-3a7jxl34 10 15 ten ten CD cord-303447-3a7jxl34 10 16 great great JJ cord-303447-3a7jxl34 10 17 public public JJ cord-303447-3a7jxl34 10 18 health health NN cord-303447-3a7jxl34 10 19 achievements achievement NNS cord-303447-3a7jxl34 10 20 ' ' '' cord-303447-3a7jxl34 10 21 ' ' '' cord-303447-3a7jxl34 10 22 of of IN cord-303447-3a7jxl34 10 23 the the DT cord-303447-3a7jxl34 10 24 twentieth twentieth JJ cord-303447-3a7jxl34 10 25 century century NN cord-303447-3a7jxl34 10 26 [ [ -LRB- cord-303447-3a7jxl34 10 27 2 2 CD cord-303447-3a7jxl34 10 28 , , , cord-303447-3a7jxl34 10 29 3 3 CD cord-303447-3a7jxl34 10 30 ] ] -RRB- cord-303447-3a7jxl34 10 31 . . . cord-303447-3a7jxl34 11 1 Today today NN cord-303447-3a7jxl34 11 2 , , , cord-303447-3a7jxl34 11 3 vaccination vaccination NN cord-303447-3a7jxl34 11 4 is be VBZ cord-303447-3a7jxl34 11 5 a a DT cord-303447-3a7jxl34 11 6 cornerstone cornerstone NN cord-303447-3a7jxl34 11 7 of of IN cord-303447-3a7jxl34 11 8 pediatric pediatric JJ cord-303447-3a7jxl34 11 9 preventive preventive JJ cord-303447-3a7jxl34 11 10 health health NN cord-303447-3a7jxl34 11 11 care care NN cord-303447-3a7jxl34 11 12 and and CC cord-303447-3a7jxl34 11 13 a a DT cord-303447-3a7jxl34 11 14 rite rite NN cord-303447-3a7jxl34 11 15 of of IN cord-303447-3a7jxl34 11 16 passage passage NN cord-303447-3a7jxl34 11 17 for for IN cord-303447-3a7jxl34 11 18 nearly nearly RB cord-303447-3a7jxl34 11 19 all all DT cord-303447-3a7jxl34 11 20 of of IN cord-303447-3a7jxl34 11 21 the the DT cord-303447-3a7jxl34 11 22 approximately approximately RB cord-303447-3a7jxl34 11 23 11,000 11,000 CD cord-303447-3a7jxl34 11 24 infants infant NNS cord-303447-3a7jxl34 11 25 born bear VBN cord-303447-3a7jxl34 11 26 daily daily RB cord-303447-3a7jxl34 11 27 in in IN cord-303447-3a7jxl34 11 28 the the DT cord-303447-3a7jxl34 11 29 United United NNP cord-303447-3a7jxl34 11 30 States States NNP cord-303447-3a7jxl34 11 31 . . . cord-303447-3a7jxl34 12 1 Immunizations immunization NNS cord-303447-3a7jxl34 12 2 have have VBP cord-303447-3a7jxl34 12 3 had have VBN cord-303447-3a7jxl34 12 4 a a DT cord-303447-3a7jxl34 12 5 profound profound JJ cord-303447-3a7jxl34 12 6 impact impact NN cord-303447-3a7jxl34 12 7 on on IN cord-303447-3a7jxl34 12 8 the the DT cord-303447-3a7jxl34 12 9 health health NN cord-303447-3a7jxl34 12 10 of of IN cord-303447-3a7jxl34 12 11 children child NNS cord-303447-3a7jxl34 12 12 , , , cord-303447-3a7jxl34 12 13 adolescents adolescent NNS cord-303447-3a7jxl34 12 14 , , , cord-303447-3a7jxl34 12 15 and and CC cord-303447-3a7jxl34 12 16 adults adult NNS cord-303447-3a7jxl34 12 17 in in IN cord-303447-3a7jxl34 12 18 the the DT cord-303447-3a7jxl34 12 19 United United NNP cord-303447-3a7jxl34 12 20 States States NNP cord-303447-3a7jxl34 12 21 ( ( -LRB- cord-303447-3a7jxl34 12 22 Table Table NNP cord-303447-3a7jxl34 12 23 1 1 CD cord-303447-3a7jxl34 12 24 ) ) -RRB- cord-303447-3a7jxl34 12 25 . . . cord-303447-3a7jxl34 13 1 The the DT cord-303447-3a7jxl34 13 2 most most RBS cord-303447-3a7jxl34 13 3 extraordinary extraordinary JJ cord-303447-3a7jxl34 13 4 success success NN cord-303447-3a7jxl34 13 5 of of IN cord-303447-3a7jxl34 13 6 immunizations immunization NNS cord-303447-3a7jxl34 13 7 was be VBD cord-303447-3a7jxl34 13 8 the the DT cord-303447-3a7jxl34 13 9 worldwide worldwide JJ cord-303447-3a7jxl34 13 10 eradication eradication NN cord-303447-3a7jxl34 13 11 of of IN cord-303447-3a7jxl34 13 12 smallpox smallpox NN cord-303447-3a7jxl34 13 13 . . . cord-303447-3a7jxl34 14 1 Declared declare VBN cord-303447-3a7jxl34 14 2 in in IN cord-303447-3a7jxl34 14 3 1980 1980 CD cord-303447-3a7jxl34 14 4 , , , cord-303447-3a7jxl34 14 5 smallpox smallpox NN cord-303447-3a7jxl34 14 6 eradication eradication NN cord-303447-3a7jxl34 14 7 was be VBD cord-303447-3a7jxl34 14 8 achieved achieve VBN cord-303447-3a7jxl34 14 9 through through IN cord-303447-3a7jxl34 14 10 an an DT cord-303447-3a7jxl34 14 11 unprecedented unprecedented JJ cord-303447-3a7jxl34 14 12 collaborative collaborative JJ cord-303447-3a7jxl34 14 13 international international JJ cord-303447-3a7jxl34 14 14 initiative initiative NN cord-303447-3a7jxl34 14 15 , , , cord-303447-3a7jxl34 14 16 led lead VBN cord-303447-3a7jxl34 14 17 by by IN cord-303447-3a7jxl34 14 18 the the DT cord-303447-3a7jxl34 14 19 World World NNP cord-303447-3a7jxl34 14 20 Health Health NNP cord-303447-3a7jxl34 14 21 Organization Organization NNP cord-303447-3a7jxl34 14 22 , , , cord-303447-3a7jxl34 14 23 establishing establish VBG cord-303447-3a7jxl34 14 24 an an DT cord-303447-3a7jxl34 14 25 example example NN cord-303447-3a7jxl34 14 26 for for IN cord-303447-3a7jxl34 14 27 other other JJ cord-303447-3a7jxl34 14 28 vaccine vaccine NN cord-303447-3a7jxl34 14 29 - - HYPH cord-303447-3a7jxl34 14 30 preventable preventable JJ cord-303447-3a7jxl34 14 31 diseases disease NNS cord-303447-3a7jxl34 14 32 [ [ -LRB- cord-303447-3a7jxl34 14 33 1 1 CD cord-303447-3a7jxl34 14 34 ] ] -RRB- cord-303447-3a7jxl34 14 35 . . . cord-303447-3a7jxl34 15 1 Vaccination vaccination NN cord-303447-3a7jxl34 15 2 since since IN cord-303447-3a7jxl34 15 3 has have VBZ cord-303447-3a7jxl34 15 4 led lead VBN cord-303447-3a7jxl34 15 5 to to IN cord-303447-3a7jxl34 15 6 elimination elimination NN cord-303447-3a7jxl34 15 7 of of IN cord-303447-3a7jxl34 15 8 wild wild JJ cord-303447-3a7jxl34 15 9 - - HYPH cord-303447-3a7jxl34 15 10 type type NN cord-303447-3a7jxl34 15 11 poliomyelitis poliomyelitis NN cord-303447-3a7jxl34 15 12 and and CC cord-303447-3a7jxl34 15 13 indigenous indigenous JJ cord-303447-3a7jxl34 15 14 measles measle NNS cord-303447-3a7jxl34 15 15 in in IN cord-303447-3a7jxl34 15 16 the the DT cord-303447-3a7jxl34 15 17 United United NNP cord-303447-3a7jxl34 15 18 States States NNP cord-303447-3a7jxl34 15 19 , , , cord-303447-3a7jxl34 15 20 both both DT cord-303447-3a7jxl34 15 21 major major JJ cord-303447-3a7jxl34 15 22 causes cause NNS cord-303447-3a7jxl34 15 23 of of IN cord-303447-3a7jxl34 15 24 pediatric pediatric JJ cord-303447-3a7jxl34 15 25 morbidity morbidity NN cord-303447-3a7jxl34 15 26 and and CC cord-303447-3a7jxl34 15 27 mortality mortality NN cord-303447-3a7jxl34 15 28 in in IN cord-303447-3a7jxl34 15 29 the the DT cord-303447-3a7jxl34 15 30 prevaccine prevaccine NN cord-303447-3a7jxl34 15 31 era era NN cord-303447-3a7jxl34 15 32 [ [ -LRB- cord-303447-3a7jxl34 15 33 4 4 CD cord-303447-3a7jxl34 15 34 , , , cord-303447-3a7jxl34 15 35 5 5 CD cord-303447-3a7jxl34 15 36 ] ] -RRB- cord-303447-3a7jxl34 15 37 . . . cord-303447-3a7jxl34 16 1 An an DT cord-303447-3a7jxl34 16 2 integral integral JJ cord-303447-3a7jxl34 16 3 part part NN cord-303447-3a7jxl34 16 4 of of IN cord-303447-3a7jxl34 16 5 achieving achieve VBG cord-303447-3a7jxl34 16 6 these these DT cord-303447-3a7jxl34 16 7 successes success NNS cord-303447-3a7jxl34 16 8 was be VBD cord-303447-3a7jxl34 16 9 establishment establishment NN cord-303447-3a7jxl34 16 10 of of IN cord-303447-3a7jxl34 16 11 a a DT cord-303447-3a7jxl34 16 12 federal federal JJ cord-303447-3a7jxl34 16 13 immunization immunization NN cord-303447-3a7jxl34 16 14 infrastructure infrastructure NN cord-303447-3a7jxl34 16 15 , , , cord-303447-3a7jxl34 16 16 which which WDT cord-303447-3a7jxl34 16 17 followed follow VBD cord-303447-3a7jxl34 16 18 the the DT cord-303447-3a7jxl34 16 19 introduction introduction NN cord-303447-3a7jxl34 16 20 of of IN cord-303447-3a7jxl34 16 21 polio polio NN cord-303447-3a7jxl34 16 22 vaccination vaccination NN cord-303447-3a7jxl34 16 23 in in IN cord-303447-3a7jxl34 16 24 the the DT cord-303447-3a7jxl34 16 25 1950s 1950 NNS cord-303447-3a7jxl34 16 26 [ [ -LRB- cord-303447-3a7jxl34 16 27 3 3 CD cord-303447-3a7jxl34 16 28 ] ] -RRB- cord-303447-3a7jxl34 16 29 . . . cord-303447-3a7jxl34 17 1 Immunization immunization NN cord-303447-3a7jxl34 17 2 programs program NNS cord-303447-3a7jxl34 17 3 , , , cord-303447-3a7jxl34 17 4 legislation legislation NN cord-303447-3a7jxl34 17 5 , , , cord-303447-3a7jxl34 17 6 and and CC cord-303447-3a7jxl34 17 7 funding fund VBG cord-303447-3a7jxl34 17 8 mecha- mecha- NNP cord-303447-3a7jxl34 17 9 nisms nisms NNP cord-303447-3a7jxl34 17 10 are be VBP cord-303447-3a7jxl34 17 11 now now RB cord-303447-3a7jxl34 17 12 in in IN cord-303447-3a7jxl34 17 13 place place NN cord-303447-3a7jxl34 17 14 to to TO cord-303447-3a7jxl34 17 15 ensure ensure VB cord-303447-3a7jxl34 17 16 that that IN cord-303447-3a7jxl34 17 17 immunizations immunization NNS cord-303447-3a7jxl34 17 18 are be VBP cord-303447-3a7jxl34 17 19 accessible accessible JJ cord-303447-3a7jxl34 17 20 to to IN cord-303447-3a7jxl34 17 21 all all DT cord-303447-3a7jxl34 17 22 children child NNS cord-303447-3a7jxl34 17 23 . . . cord-303447-3a7jxl34 18 1 As as IN cord-303447-3a7jxl34 18 2 a a DT cord-303447-3a7jxl34 18 3 result result NN cord-303447-3a7jxl34 18 4 , , , cord-303447-3a7jxl34 18 5 coverage coverage NN cord-303447-3a7jxl34 18 6 levels level NNS cord-303447-3a7jxl34 18 7 for for IN cord-303447-3a7jxl34 18 8 most most JJS cord-303447-3a7jxl34 18 9 routinely routinely RB cord-303447-3a7jxl34 18 10 recommended recommend VBN cord-303447-3a7jxl34 18 11 childhood childhood NN cord-303447-3a7jxl34 18 12 vaccines vaccine NNS cord-303447-3a7jxl34 18 13 in in IN cord-303447-3a7jxl34 18 14 the the DT cord-303447-3a7jxl34 18 15 United United NNP cord-303447-3a7jxl34 18 16 States States NNP cord-303447-3a7jxl34 18 17 are be VBP cord-303447-3a7jxl34 18 18 approaching approach VBG cord-303447-3a7jxl34 18 19 or or CC cord-303447-3a7jxl34 18 20 have have VBP cord-303447-3a7jxl34 18 21 surpassed surpass VBN cord-303447-3a7jxl34 18 22 the the DT cord-303447-3a7jxl34 18 23 US US NNP cord-303447-3a7jxl34 18 24 Department Department NNP cord-303447-3a7jxl34 18 25 of of IN cord-303447-3a7jxl34 18 26 Health Health NNP cord-303447-3a7jxl34 18 27 and and CC cord-303447-3a7jxl34 18 28 Human Human NNP cord-303447-3a7jxl34 18 29 Services Services NNPS cord-303447-3a7jxl34 18 30 Healthy Healthy NNP cord-303447-3a7jxl34 18 31 People People NNPS cord-303447-3a7jxl34 18 32 2010 2010 CD cord-303447-3a7jxl34 18 33 goal goal NN cord-303447-3a7jxl34 18 34 of of IN cord-303447-3a7jxl34 18 35 90 90 CD cord-303447-3a7jxl34 18 36 % % NN cord-303447-3a7jxl34 18 37 coverage coverage NN cord-303447-3a7jxl34 18 38 [ [ -LRB- cord-303447-3a7jxl34 18 39 6 6 CD cord-303447-3a7jxl34 18 40 ] ] -RRB- cord-303447-3a7jxl34 18 41 . . . cord-303447-3a7jxl34 19 1 Immunizations immunization NNS cord-303447-3a7jxl34 19 2 have have VBP cord-303447-3a7jxl34 19 3 changed change VBN cord-303447-3a7jxl34 19 4 the the DT cord-303447-3a7jxl34 19 5 scope scope NN cord-303447-3a7jxl34 19 6 of of IN cord-303447-3a7jxl34 19 7 pediatric pediatric JJ cord-303447-3a7jxl34 19 8 practice practice NN cord-303447-3a7jxl34 19 9 in in IN cord-303447-3a7jxl34 19 10 the the DT cord-303447-3a7jxl34 19 11 United United NNP cord-303447-3a7jxl34 19 12 States States NNP cord-303447-3a7jxl34 19 13 . . . cord-303447-3a7jxl34 20 1 Pediatric pediatric JJ cord-303447-3a7jxl34 20 2 residents resident NNS cord-303447-3a7jxl34 20 3 now now RB cord-303447-3a7jxl34 20 4 infrequently infrequently RB cord-303447-3a7jxl34 20 5 encounter encounter VBP cord-303447-3a7jxl34 20 6 varicella varicella NN cord-303447-3a7jxl34 20 7 , , , cord-303447-3a7jxl34 20 8 which which WDT cord-303447-3a7jxl34 20 9 in in IN cord-303447-3a7jxl34 20 10 the the DT cord-303447-3a7jxl34 20 11 1990s 1990s CD cord-303447-3a7jxl34 20 12 was be VBD cord-303447-3a7jxl34 20 13 commonplace commonplace JJ cord-303447-3a7jxl34 20 14 . . . cord-303447-3a7jxl34 21 1 Likewise likewise RB cord-303447-3a7jxl34 21 2 , , , cord-303447-3a7jxl34 21 3 although although IN cord-303447-3a7jxl34 21 4 Haemophilus haemophilus JJ cord-303447-3a7jxl34 21 5 influenzae influenzae NN cord-303447-3a7jxl34 21 6 type type NN cord-303447-3a7jxl34 21 7 b b NN cord-303447-3a7jxl34 21 8 ( ( -LRB- cord-303447-3a7jxl34 21 9 Hib Hib NNP cord-303447-3a7jxl34 21 10 ) ) -RRB- cord-303447-3a7jxl34 21 11 was be VBD cord-303447-3a7jxl34 21 12 the the DT cord-303447-3a7jxl34 21 13 leading leading JJ cord-303447-3a7jxl34 21 14 cause cause NN cord-303447-3a7jxl34 21 15 of of IN cord-303447-3a7jxl34 21 16 meningitis meningitis NN cord-303447-3a7jxl34 21 17 in in IN cord-303447-3a7jxl34 21 18 young young JJ cord-303447-3a7jxl34 21 19 children child NNS cord-303447-3a7jxl34 21 20 before before IN cord-303447-3a7jxl34 21 21 availability availability NN cord-303447-3a7jxl34 21 22 of of IN cord-303447-3a7jxl34 21 23 Hib Hib NNP cord-303447-3a7jxl34 21 24 vaccines vaccine NNS cord-303447-3a7jxl34 21 25 in in IN cord-303447-3a7jxl34 21 26 1985 1985 CD cord-303447-3a7jxl34 21 27 , , , cord-303447-3a7jxl34 21 28 most most RBS cord-303447-3a7jxl34 21 29 newly newly RB cord-303447-3a7jxl34 21 30 trained train VBN cord-303447-3a7jxl34 21 31 pediatricians pediatrician NNS cord-303447-3a7jxl34 21 32 will will MD cord-303447-3a7jxl34 21 33 never never RB cord-303447-3a7jxl34 21 34 see see VB cord-303447-3a7jxl34 21 35 a a DT cord-303447-3a7jxl34 21 36 case case NN cord-303447-3a7jxl34 21 37 of of IN cord-303447-3a7jxl34 21 38 invasive invasive JJ cord-303447-3a7jxl34 21 39 Hib Hib NNP cord-303447-3a7jxl34 21 40 [ [ -LRB- cord-303447-3a7jxl34 21 41 7 7 CD cord-303447-3a7jxl34 21 42 ] ] -RRB- cord-303447-3a7jxl34 21 43 . . . cord-303447-3a7jxl34 22 1 This this DT cord-303447-3a7jxl34 22 2 article article NN cord-303447-3a7jxl34 22 3 reviews review VBZ cord-303447-3a7jxl34 22 4 the the DT cord-303447-3a7jxl34 22 5 US US NNP cord-303447-3a7jxl34 22 6 immunization immunization NN cord-303447-3a7jxl34 22 7 program program NN cord-303447-3a7jxl34 22 8 with with IN cord-303447-3a7jxl34 22 9 an an DT cord-303447-3a7jxl34 22 10 emphasis emphasis NN cord-303447-3a7jxl34 22 11 on on IN cord-303447-3a7jxl34 22 12 its -PRON- PRP$ cord-303447-3a7jxl34 22 13 role role NN cord-303447-3a7jxl34 22 14 in in IN cord-303447-3a7jxl34 22 15 ensuring ensure VBG cord-303447-3a7jxl34 22 16 that that IN cord-303447-3a7jxl34 22 17 vaccines vaccine NNS cord-303447-3a7jxl34 22 18 are be VBP cord-303447-3a7jxl34 22 19 effective effective JJ cord-303447-3a7jxl34 22 20 , , , cord-303447-3a7jxl34 22 21 safe safe JJ cord-303447-3a7jxl34 22 22 , , , cord-303447-3a7jxl34 22 23 and and CC cord-303447-3a7jxl34 22 24 available available JJ cord-303447-3a7jxl34 22 25 and and CC cord-303447-3a7jxl34 22 26 highlights highlight VBZ cord-303447-3a7jxl34 22 27 several several JJ cord-303447-3a7jxl34 22 28 new new JJ cord-303447-3a7jxl34 22 29 vaccines vaccine NNS cord-303447-3a7jxl34 22 30 and and CC cord-303447-3a7jxl34 22 31 recommendations recommendation NNS cord-303447-3a7jxl34 22 32 that that WDT cord-303447-3a7jxl34 22 33 will will MD cord-303447-3a7jxl34 22 34 affect affect VB cord-303447-3a7jxl34 22 35 the the DT cord-303447-3a7jxl34 22 36 health health NN cord-303447-3a7jxl34 22 37 of of IN cord-303447-3a7jxl34 22 38 children child NNS cord-303447-3a7jxl34 22 39 and and CC cord-303447-3a7jxl34 22 40 adolescents adolescent NNS cord-303447-3a7jxl34 22 41 and and CC cord-303447-3a7jxl34 22 42 the the DT cord-303447-3a7jxl34 22 43 practice practice NN cord-303447-3a7jxl34 22 44 of of IN cord-303447-3a7jxl34 22 45 pediatric pediatric JJ cord-303447-3a7jxl34 22 46 medicine medicine NN cord-303447-3a7jxl34 22 47 in in IN cord-303447-3a7jxl34 22 48 future future JJ cord-303447-3a7jxl34 22 49 decades decade NNS cord-303447-3a7jxl34 22 50 . . . cord-303447-3a7jxl34 23 1 Childhood childhood NN cord-303447-3a7jxl34 23 2 and and CC cord-303447-3a7jxl34 23 3 adolescent adolescent JJ cord-303447-3a7jxl34 23 4 immunization immunization NN cord-303447-3a7jxl34 23 5 schedule schedule NN cord-303447-3a7jxl34 24 1 The the DT cord-303447-3a7jxl34 24 2 Centers Centers NNPS cord-303447-3a7jxl34 24 3 for for IN cord-303447-3a7jxl34 24 4 Disease Disease NNP cord-303447-3a7jxl34 24 5 Control Control NNP cord-303447-3a7jxl34 24 6 and and CC cord-303447-3a7jxl34 24 7 Prevention Prevention NNP cord-303447-3a7jxl34 24 8 ( ( -LRB- cord-303447-3a7jxl34 24 9 CDC CDC NNP cord-303447-3a7jxl34 24 10 ) ) -RRB- cord-303447-3a7jxl34 24 11 , , , cord-303447-3a7jxl34 24 12 American American NNP cord-303447-3a7jxl34 24 13 Academy Academy NNP cord-303447-3a7jxl34 24 14 of of IN cord-303447-3a7jxl34 24 15 Family Family NNP cord-303447-3a7jxl34 24 16 Physicians Physicians NNPS cord-303447-3a7jxl34 24 17 , , , cord-303447-3a7jxl34 24 18 and and CC cord-303447-3a7jxl34 24 19 American American NNP cord-303447-3a7jxl34 24 20 Academy Academy NNP cord-303447-3a7jxl34 24 21 of of IN cord-303447-3a7jxl34 24 22 Pediatrics Pediatrics NNP cord-303447-3a7jxl34 24 23 ( ( -LRB- cord-303447-3a7jxl34 24 24 AAP AAP NNP cord-303447-3a7jxl34 24 25 ) ) -RRB- cord-303447-3a7jxl34 24 26 annually annually RB cord-303447-3a7jxl34 24 27 publish publish VB cord-303447-3a7jxl34 24 28 a a DT cord-303447-3a7jxl34 24 29 childhood childhood NN cord-303447-3a7jxl34 24 30 and and CC cord-303447-3a7jxl34 24 31 adolescent adolescent JJ cord-303447-3a7jxl34 24 32 immunization immunization NN cord-303447-3a7jxl34 24 33 schedule schedule NN cord-303447-3a7jxl34 24 34 . . . cord-303447-3a7jxl34 25 1 The the DT cord-303447-3a7jxl34 25 2 Advisory Advisory NNP cord-303447-3a7jxl34 25 3 Committee Committee NNP cord-303447-3a7jxl34 25 4 on on IN cord-303447-3a7jxl34 25 5 Immunization Immunization NNP cord-303447-3a7jxl34 25 6 Practices Practices NNPS cord-303447-3a7jxl34 25 7 ( ( -LRB- cord-303447-3a7jxl34 25 8 ACIP ACIP NNP cord-303447-3a7jxl34 25 9 ) ) -RRB- cord-303447-3a7jxl34 25 10 , , , cord-303447-3a7jxl34 25 11 with with IN cord-303447-3a7jxl34 25 12 input input NN cord-303447-3a7jxl34 25 13 from from IN cord-303447-3a7jxl34 25 14 many many JJ cord-303447-3a7jxl34 25 15 liaison liaison NN cord-303447-3a7jxl34 25 16 organizations organization NNS cord-303447-3a7jxl34 25 17 , , , cord-303447-3a7jxl34 25 18 periodically periodically RB cord-303447-3a7jxl34 25 19 reviews review VBZ cord-303447-3a7jxl34 25 20 the the DT cord-303447-3a7jxl34 25 21 schedule schedule NN cord-303447-3a7jxl34 25 22 to to TO cord-303447-3a7jxl34 25 23 ensure ensure VB cord-303447-3a7jxl34 25 24 consistency consistency NN cord-303447-3a7jxl34 25 25 with with IN cord-303447-3a7jxl34 25 26 new new JJ cord-303447-3a7jxl34 25 27 vaccine vaccine NN cord-303447-3a7jxl34 25 28 developments development NNS cord-303447-3a7jxl34 25 29 and and CC cord-303447-3a7jxl34 25 30 policies policy NNS cord-303447-3a7jxl34 25 31 [ [ -LRB- cord-303447-3a7jxl34 25 32 8 8 CD cord-303447-3a7jxl34 25 33 ] ] -RRB- cord-303447-3a7jxl34 25 34 . . . cord-303447-3a7jxl34 26 1 The the DT cord-303447-3a7jxl34 26 2 first first JJ cord-303447-3a7jxl34 26 3 combined combined JJ cord-303447-3a7jxl34 26 4 immunization immunization NN cord-303447-3a7jxl34 26 5 schedule schedule NN cord-303447-3a7jxl34 26 6 was be VBD cord-303447-3a7jxl34 26 7 published publish VBN cord-303447-3a7jxl34 26 8 in in IN cord-303447-3a7jxl34 26 9 1995 1995 CD cord-303447-3a7jxl34 26 10 and and CC cord-303447-3a7jxl34 26 11 recommended recommend VBD cord-303447-3a7jxl34 26 12 six six CD cord-303447-3a7jxl34 26 13 vaccines vaccine NNS cord-303447-3a7jxl34 26 14 containing contain VBG cord-303447-3a7jxl34 26 15 antigens antigen NNS cord-303447-3a7jxl34 26 16 against against IN cord-303447-3a7jxl34 26 17 nine nine CD cord-303447-3a7jxl34 26 18 infectious infectious JJ cord-303447-3a7jxl34 26 19 diseases disease NNS cord-303447-3a7jxl34 26 20 [ [ -LRB- cord-303447-3a7jxl34 26 21 9 9 CD cord-303447-3a7jxl34 26 22 ] ] -RRB- cord-303447-3a7jxl34 26 23 : : : cord-303447-3a7jxl34 26 24 diphtheria diphtheria NN cord-303447-3a7jxl34 26 25 and and CC cord-303447-3a7jxl34 26 26 tetanus tetanus NN cord-303447-3a7jxl34 26 27 toxoids toxoid NNS cord-303447-3a7jxl34 26 28 and and CC cord-303447-3a7jxl34 26 29 whole whole JJ cord-303447-3a7jxl34 26 30 - - HYPH cord-303447-3a7jxl34 26 31 cell cell NN cord-303447-3a7jxl34 26 32 pertussis pertussis NN cord-303447-3a7jxl34 26 33 vaccine vaccine NN cord-303447-3a7jxl34 26 34 ( ( -LRB- cord-303447-3a7jxl34 26 35 DTP DTP NNP cord-303447-3a7jxl34 26 36 ) ) -RRB- cord-303447-3a7jxl34 26 37 ; ; : cord-303447-3a7jxl34 26 38 tetanus tetanus NN cord-303447-3a7jxl34 26 39 and and CC cord-303447-3a7jxl34 26 40 diphtheria diphtheria NN cord-303447-3a7jxl34 26 41 toxoids toxoid NNS cord-303447-3a7jxl34 26 42 ( ( -LRB- cord-303447-3a7jxl34 26 43 Td Td NNP cord-303447-3a7jxl34 26 44 ) ) -RRB- cord-303447-3a7jxl34 26 45 ; ; : cord-303447-3a7jxl34 26 46 measles measle NNS cord-303447-3a7jxl34 26 47 , , , cord-303447-3a7jxl34 26 48 mumps mumps NN cord-303447-3a7jxl34 26 49 , , , cord-303447-3a7jxl34 26 50 and and CC cord-303447-3a7jxl34 26 51 rubella rubella NN cord-303447-3a7jxl34 26 52 vaccine vaccine NN cord-303447-3a7jxl34 26 53 ( ( -LRB- cord-303447-3a7jxl34 26 54 MMR MMR NNP cord-303447-3a7jxl34 26 55 ) ) -RRB- cord-303447-3a7jxl34 26 56 ; ; : cord-303447-3a7jxl34 26 57 Hib Hib NNP cord-303447-3a7jxl34 26 58 ; ; : cord-303447-3a7jxl34 26 59 oral oral JJ cord-303447-3a7jxl34 26 60 polio polio NN cord-303447-3a7jxl34 26 61 vaccine vaccine NN cord-303447-3a7jxl34 26 62 ( ( -LRB- cord-303447-3a7jxl34 26 63 OPV OPV NNP cord-303447-3a7jxl34 26 64 ) ) -RRB- cord-303447-3a7jxl34 26 65 ; ; : cord-303447-3a7jxl34 26 66 and and CC cord-303447-3a7jxl34 26 67 hepatitis hepatitis NNP cord-303447-3a7jxl34 26 68 B B NNP cord-303447-3a7jxl34 26 69 virus virus NN cord-303447-3a7jxl34 26 70 vaccine vaccine NN cord-303447-3a7jxl34 26 71 . . . cord-303447-3a7jxl34 27 1 Ten ten CD cord-303447-3a7jxl34 27 2 years year NNS cord-303447-3a7jxl34 27 3 later later RB cord-303447-3a7jxl34 27 4 in in IN cord-303447-3a7jxl34 27 5 February February NNP cord-303447-3a7jxl34 27 6 2005 2005 CD cord-303447-3a7jxl34 27 7 , , , cord-303447-3a7jxl34 27 8 there there EX cord-303447-3a7jxl34 27 9 were be VBD cord-303447-3a7jxl34 27 10 ten ten CD cord-303447-3a7jxl34 27 11 vaccines vaccine NNS cord-303447-3a7jxl34 27 12 against against IN cord-303447-3a7jxl34 27 13 13 13 CD cord-303447-3a7jxl34 27 14 [ [ -LRB- cord-303447-3a7jxl34 27 15 8 8 CD cord-303447-3a7jxl34 27 16 ] ] -RRB- cord-303447-3a7jxl34 27 17 . . . cord-303447-3a7jxl34 28 1 Before before IN cord-303447-3a7jxl34 28 2 a a DT cord-303447-3a7jxl34 28 3 vaccination vaccination NN cord-303447-3a7jxl34 28 4 becomes become VBZ cord-303447-3a7jxl34 28 5 part part NN cord-303447-3a7jxl34 28 6 of of IN cord-303447-3a7jxl34 28 7 routine routine JJ cord-303447-3a7jxl34 28 8 clinical clinical JJ cord-303447-3a7jxl34 28 9 pediatric pediatric JJ cord-303447-3a7jxl34 28 10 practice practice NN cord-303447-3a7jxl34 28 11 , , , cord-303447-3a7jxl34 28 12 three three CD cord-303447-3a7jxl34 28 13 steps step NNS cord-303447-3a7jxl34 28 14 need need VBP cord-303447-3a7jxl34 28 15 to to TO cord-303447-3a7jxl34 28 16 be be VB cord-303447-3a7jxl34 28 17 taken take VBN cord-303447-3a7jxl34 28 18 : : : cord-303447-3a7jxl34 28 19 ( ( -LRB- cord-303447-3a7jxl34 28 20 1 1 LS cord-303447-3a7jxl34 28 21 ) ) -RRB- cord-303447-3a7jxl34 28 22 the the DT cord-303447-3a7jxl34 28 23 FDA FDA NNP cord-303447-3a7jxl34 28 24 must must MD cord-303447-3a7jxl34 28 25 license license VB cord-303447-3a7jxl34 28 26 the the DT cord-303447-3a7jxl34 28 27 vaccine vaccine NN cord-303447-3a7jxl34 28 28 , , , cord-303447-3a7jxl34 28 29 ( ( -LRB- cord-303447-3a7jxl34 28 30 2 2 LS cord-303447-3a7jxl34 28 31 ) ) -RRB- cord-303447-3a7jxl34 28 32 the the DT cord-303447-3a7jxl34 28 33 ACIP ACIP NNP cord-303447-3a7jxl34 28 34 and and CC cord-303447-3a7jxl34 28 35 the the DT cord-303447-3a7jxl34 28 36 Committee Committee NNP cord-303447-3a7jxl34 28 37 on on IN cord-303447-3a7jxl34 28 38 Infectious Infectious NNP cord-303447-3a7jxl34 28 39 Diseases Diseases NNPS cord-303447-3a7jxl34 28 40 of of IN cord-303447-3a7jxl34 28 41 the the DT cord-303447-3a7jxl34 28 42 AAP AAP NNP cord-303447-3a7jxl34 28 43 and and CC cord-303447-3a7jxl34 28 44 AAFP AAFP NNP cord-303447-3a7jxl34 28 45 must must MD cord-303447-3a7jxl34 28 46 recommend recommend VB cord-303447-3a7jxl34 28 47 the the DT cord-303447-3a7jxl34 28 48 vaccine vaccine NN cord-303447-3a7jxl34 28 49 for for IN cord-303447-3a7jxl34 28 50 use use NN cord-303447-3a7jxl34 28 51 , , , cord-303447-3a7jxl34 28 52 and and CC cord-303447-3a7jxl34 28 53 ( ( -LRB- cord-303447-3a7jxl34 28 54 3 3 LS cord-303447-3a7jxl34 28 55 ) ) -RRB- cord-303447-3a7jxl34 28 56 the the DT cord-303447-3a7jxl34 28 57 vaccine vaccine NN cord-303447-3a7jxl34 28 58 must must MD cord-303447-3a7jxl34 28 59 be be VB cord-303447-3a7jxl34 28 60 subsidized subsidize VBN cord-303447-3a7jxl34 28 61 to to TO cord-303447-3a7jxl34 28 62 cover cover VB cord-303447-3a7jxl34 28 63 children child NNS cord-303447-3a7jxl34 28 64 without without IN cord-303447-3a7jxl34 28 65 private private JJ cord-303447-3a7jxl34 28 66 health health NN cord-303447-3a7jxl34 28 67 insurance insurance NN cord-303447-3a7jxl34 28 68 . . . cord-303447-3a7jxl34 29 1 Numerous numerous JJ cord-303447-3a7jxl34 29 2 government government NN cord-303447-3a7jxl34 29 3 and and CC cord-303447-3a7jxl34 29 4 partner partner NN cord-303447-3a7jxl34 29 5 organizations organization NNS cord-303447-3a7jxl34 29 6 participate participate VBP cord-303447-3a7jxl34 29 7 in in IN cord-303447-3a7jxl34 29 8 bringing bring VBG cord-303447-3a7jxl34 29 9 a a DT cord-303447-3a7jxl34 29 10 vaccine vaccine NN cord-303447-3a7jxl34 29 11 from from IN cord-303447-3a7jxl34 29 12 the the DT cord-303447-3a7jxl34 29 13 bench bench NN cord-303447-3a7jxl34 29 14 into into IN cord-303447-3a7jxl34 29 15 the the DT cord-303447-3a7jxl34 29 16 clinic clinic NN cord-303447-3a7jxl34 29 17 . . . cord-303447-3a7jxl34 30 1 Table table NN cord-303447-3a7jxl34 30 2 2 2 CD cord-303447-3a7jxl34 30 3 provides provide VBZ cord-303447-3a7jxl34 30 4 links link NNS cord-303447-3a7jxl34 30 5 where where WRB cord-303447-3a7jxl34 30 6 information information NN cord-303447-3a7jxl34 30 7 about about IN cord-303447-3a7jxl34 30 8 these these DT cord-303447-3a7jxl34 30 9 organizations organization NNS cord-303447-3a7jxl34 30 10 can can MD cord-303447-3a7jxl34 30 11 be be VB cord-303447-3a7jxl34 30 12 obtained obtain VBN cord-303447-3a7jxl34 30 13 . . . cord-303447-3a7jxl34 31 1 Before before IN cord-303447-3a7jxl34 31 2 FDA FDA NNP cord-303447-3a7jxl34 31 3 licensure licensure NN cord-303447-3a7jxl34 31 4 , , , cord-303447-3a7jxl34 31 5 a a DT cord-303447-3a7jxl34 31 6 new new JJ cord-303447-3a7jxl34 31 7 vaccine vaccine NN cord-303447-3a7jxl34 31 8 goes go VBZ cord-303447-3a7jxl34 31 9 through through IN cord-303447-3a7jxl34 31 10 10 10 CD cord-303447-3a7jxl34 31 11 to to TO cord-303447-3a7jxl34 31 12 15 15 CD cord-303447-3a7jxl34 31 13 years year NNS cord-303447-3a7jxl34 31 14 of of IN cord-303447-3a7jxl34 31 15 preclinical preclinical JJ cord-303447-3a7jxl34 31 16 testing testing NN cord-303447-3a7jxl34 31 17 and and CC cord-303447-3a7jxl34 31 18 clinical clinical JJ cord-303447-3a7jxl34 31 19 trials trial NNS cord-303447-3a7jxl34 31 20 , , , cord-303447-3a7jxl34 31 21 costing cost VBG cord-303447-3a7jxl34 31 22 pharmaceutical pharmaceutical JJ cord-303447-3a7jxl34 31 23 companies company NNS cord-303447-3a7jxl34 31 24 millions million NNS cord-303447-3a7jxl34 31 25 of of IN cord-303447-3a7jxl34 31 26 dollars dollar NNS cord-303447-3a7jxl34 31 27 in in IN cord-303447-3a7jxl34 31 28 new new JJ cord-303447-3a7jxl34 31 29 development development NN cord-303447-3a7jxl34 31 30 costs cost NNS cord-303447-3a7jxl34 31 31 . . . cord-303447-3a7jxl34 32 1 Before before IN cord-303447-3a7jxl34 32 2 testing test VBG cord-303447-3a7jxl34 32 3 the the DT cord-303447-3a7jxl34 32 4 vaccine vaccine NN cord-303447-3a7jxl34 32 5 in in IN cord-303447-3a7jxl34 32 6 humans human NNS cord-303447-3a7jxl34 32 7 , , , cord-303447-3a7jxl34 32 8 a a DT cord-303447-3a7jxl34 32 9 company company NN cord-303447-3a7jxl34 32 10 files file VBZ cord-303447-3a7jxl34 32 11 an an DT cord-303447-3a7jxl34 32 12 Investigational Investigational NNP cord-303447-3a7jxl34 32 13 New New NNP cord-303447-3a7jxl34 32 14 Drug Drug NNP cord-303447-3a7jxl34 32 15 application application NN cord-303447-3a7jxl34 32 16 with with IN cord-303447-3a7jxl34 32 17 the the DT cord-303447-3a7jxl34 32 18 FDA FDA NNP cord-303447-3a7jxl34 32 19 followed follow VBD cord-303447-3a7jxl34 32 20 by by IN cord-303447-3a7jxl34 32 21 three three CD cord-303447-3a7jxl34 32 22 phases phase NNS cord-303447-3a7jxl34 32 23 of of IN cord-303447-3a7jxl34 32 24 clinical clinical JJ cord-303447-3a7jxl34 32 25 trials trial NNS cord-303447-3a7jxl34 32 26 that that WDT cord-303447-3a7jxl34 32 27 are be VBP cord-303447-3a7jxl34 32 28 performed perform VBN cord-303447-3a7jxl34 32 29 to to TO cord-303447-3a7jxl34 32 30 study study VB cord-303447-3a7jxl34 32 31 vaccine vaccine NN cord-303447-3a7jxl34 32 32 safety safety NN cord-303447-3a7jxl34 32 33 , , , cord-303447-3a7jxl34 32 34 immunogenicity immunogenicity NN cord-303447-3a7jxl34 32 35 , , , cord-303447-3a7jxl34 32 36 and and CC cord-303447-3a7jxl34 32 37 efficacy efficacy NN cord-303447-3a7jxl34 32 38 ( ( -LRB- cord-303447-3a7jxl34 32 39 Table Table NNP cord-303447-3a7jxl34 32 40 3 3 CD cord-303447-3a7jxl34 32 41 ) ) -RRB- cord-303447-3a7jxl34 32 42 [ [ -LRB- cord-303447-3a7jxl34 32 43 10 10 CD cord-303447-3a7jxl34 32 44 ] ] -RRB- cord-303447-3a7jxl34 32 45 . . . cord-303447-3a7jxl34 33 1 After after IN cord-303447-3a7jxl34 33 2 completion completion NN cord-303447-3a7jxl34 33 3 of of IN cord-303447-3a7jxl34 33 4 the the DT cord-303447-3a7jxl34 33 5 prelicensure prelicensure JJ cord-303447-3a7jxl34 33 6 clinical clinical JJ cord-303447-3a7jxl34 33 7 trials trial NNS cord-303447-3a7jxl34 33 8 , , , cord-303447-3a7jxl34 33 9 the the DT cord-303447-3a7jxl34 33 10 manufacturer manufacturer NN cord-303447-3a7jxl34 33 11 files file VBZ cord-303447-3a7jxl34 33 12 a a DT cord-303447-3a7jxl34 33 13 Biologics Biologics NNP cord-303447-3a7jxl34 33 14 Licensure Licensure NNP cord-303447-3a7jxl34 33 15 Application Application NNP cord-303447-3a7jxl34 33 16 ( ( -LRB- cord-303447-3a7jxl34 33 17 BLA BLA NNP cord-303447-3a7jxl34 33 18 ) ) -RRB- cord-303447-3a7jxl34 33 19 , , , cord-303447-3a7jxl34 33 20 and and CC cord-303447-3a7jxl34 33 21 the the DT cord-303447-3a7jxl34 33 22 FDA FDA NNP cord-303447-3a7jxl34 33 23 , , , cord-303447-3a7jxl34 33 24 with with IN cord-303447-3a7jxl34 33 25 input input NN cord-303447-3a7jxl34 33 26 from from IN cord-303447-3a7jxl34 33 27 its -PRON- PRP$ cord-303447-3a7jxl34 33 28 advisory advisory JJ cord-303447-3a7jxl34 33 29 committee committee NN cord-303447-3a7jxl34 33 30 , , , cord-303447-3a7jxl34 33 31 determines determine VBZ cord-303447-3a7jxl34 33 32 if if IN cord-303447-3a7jxl34 33 33 data datum NNS cord-303447-3a7jxl34 33 34 support support NN cord-303447-3a7jxl34 33 35 vaccine vaccine NN cord-303447-3a7jxl34 33 36 safety safety NN cord-303447-3a7jxl34 33 37 , , , cord-303447-3a7jxl34 33 38 immunogenicity immunogenicity NN cord-303447-3a7jxl34 33 39 , , , cord-303447-3a7jxl34 33 40 and and CC cord-303447-3a7jxl34 33 41 efficacy efficacy NN cord-303447-3a7jxl34 33 42 ( ( -LRB- cord-303447-3a7jxl34 33 43 Fig Fig NNP cord-303447-3a7jxl34 33 44 . . . cord-303447-3a7jxl34 33 45 1 1 CD cord-303447-3a7jxl34 33 46 ) ) -RRB- cord-303447-3a7jxl34 34 1 [ [ -LRB- cord-303447-3a7jxl34 34 2 11 11 CD cord-303447-3a7jxl34 34 3 ] ] -RRB- cord-303447-3a7jxl34 34 4 . . . cord-303447-3a7jxl34 35 1 After after IN cord-303447-3a7jxl34 35 2 licensure licensure NN cord-303447-3a7jxl34 35 3 , , , cord-303447-3a7jxl34 35 4 monitoring monitor VBG cord-303447-3a7jxl34 35 5 for for IN cord-303447-3a7jxl34 35 6 rare rare JJ cord-303447-3a7jxl34 35 7 adverse adverse JJ cord-303447-3a7jxl34 35 8 events event NNS cord-303447-3a7jxl34 35 9 continues continue VBZ cord-303447-3a7jxl34 35 10 for for IN cord-303447-3a7jxl34 35 11 some some DT cord-303447-3a7jxl34 35 12 vaccines vaccine NNS cord-303447-3a7jxl34 35 13 through through IN cord-303447-3a7jxl34 35 14 formal formal JJ cord-303447-3a7jxl34 35 15 phase phase NN cord-303447-3a7jxl34 35 16 IV IV NNP cord-303447-3a7jxl34 35 17 trials trial NNS cord-303447-3a7jxl34 35 18 conducted conduct VBN cord-303447-3a7jxl34 35 19 by by IN cord-303447-3a7jxl34 35 20 the the DT cord-303447-3a7jxl34 35 21 FDA FDA NNP cord-303447-3a7jxl34 35 22 and and CC cord-303447-3a7jxl34 35 23 manufacturer manufacturer NN cord-303447-3a7jxl34 35 24 . . . cord-303447-3a7jxl34 36 1 After after IN cord-303447-3a7jxl34 36 2 FDA FDA NNP cord-303447-3a7jxl34 36 3 licensure licensure NN cord-303447-3a7jxl34 36 4 of of IN cord-303447-3a7jxl34 36 5 a a DT cord-303447-3a7jxl34 36 6 new new JJ cord-303447-3a7jxl34 36 7 vaccine vaccine NN cord-303447-3a7jxl34 36 8 , , , cord-303447-3a7jxl34 36 9 information information NN cord-303447-3a7jxl34 36 10 about about IN cord-303447-3a7jxl34 36 11 the the DT cord-303447-3a7jxl34 36 12 vaccine vaccine NN cord-303447-3a7jxl34 36 13 is be VBZ cord-303447-3a7jxl34 36 14 reviewed review VBN cord-303447-3a7jxl34 36 15 by by IN cord-303447-3a7jxl34 36 16 the the DT cord-303447-3a7jxl34 36 17 ACIP ACIP NNP cord-303447-3a7jxl34 36 18 . . . cord-303447-3a7jxl34 37 1 The the DT cord-303447-3a7jxl34 37 2 ACIP ACIP NNP cord-303447-3a7jxl34 37 3 comprises comprise VBZ cord-303447-3a7jxl34 37 4 15 15 CD cord-303447-3a7jxl34 37 5 voting voting NN cord-303447-3a7jxl34 37 6 members member NNS cord-303447-3a7jxl34 37 7 appointed appoint VBN cord-303447-3a7jxl34 37 8 by by IN cord-303447-3a7jxl34 37 9 the the DT cord-303447-3a7jxl34 37 10 Secretary Secretary NNP cord-303447-3a7jxl34 37 11 of of IN cord-303447-3a7jxl34 37 12 the the DT cord-303447-3a7jxl34 37 13 Department Department NNP cord-303447-3a7jxl34 37 14 of of IN cord-303447-3a7jxl34 37 15 Health Health NNP cord-303447-3a7jxl34 37 16 and and CC cord-303447-3a7jxl34 37 17 Human Human NNP cord-303447-3a7jxl34 37 18 Services Services NNPS cord-303447-3a7jxl34 37 19 . . . cord-303447-3a7jxl34 38 1 In in IN cord-303447-3a7jxl34 38 2 addition addition NN cord-303447-3a7jxl34 38 3 , , , cord-303447-3a7jxl34 38 4 several several JJ cord-303447-3a7jxl34 38 5 professional professional JJ cord-303447-3a7jxl34 38 6 medical medical JJ cord-303447-3a7jxl34 38 7 and and CC cord-303447-3a7jxl34 38 8 public public JJ cord-303447-3a7jxl34 38 9 health health NN cord-303447-3a7jxl34 38 10 groups group NNS cord-303447-3a7jxl34 38 11 and and CC cord-303447-3a7jxl34 38 12 industry industry NN cord-303447-3a7jxl34 38 13 representatives representative NNS cord-303447-3a7jxl34 38 14 participate participate VBP cord-303447-3a7jxl34 38 15 in in IN cord-303447-3a7jxl34 38 16 ACIP ACIP NNP cord-303447-3a7jxl34 38 17 discussions discussion NNS cord-303447-3a7jxl34 38 18 . . . cord-303447-3a7jxl34 39 1 To to TO cord-303447-3a7jxl34 39 2 formulate formulate VB cord-303447-3a7jxl34 39 3 recommendations recommendation NNS cord-303447-3a7jxl34 39 4 , , , cord-303447-3a7jxl34 39 5 the the DT cord-303447-3a7jxl34 39 6 ACIP ACIP NNP cord-303447-3a7jxl34 39 7 establishes establish VBZ cord-303447-3a7jxl34 39 8 subject subject RB cord-303447-3a7jxl34 39 9 - - HYPH cord-303447-3a7jxl34 39 10 specific specific JJ cord-303447-3a7jxl34 39 11 working work VBG cord-303447-3a7jxl34 39 12 groups group NNS cord-303447-3a7jxl34 39 13 to to TO cord-303447-3a7jxl34 39 14 review review VB cord-303447-3a7jxl34 39 15 and and CC cord-303447-3a7jxl34 39 16 synthesize synthesize VB cord-303447-3a7jxl34 39 17 data datum NNS cord-303447-3a7jxl34 39 18 months month NNS cord-303447-3a7jxl34 39 19 to to IN cord-303447-3a7jxl34 39 20 Ensuring ensure VBG cord-303447-3a7jxl34 39 21 that that IN cord-303447-3a7jxl34 39 22 all all DT cord-303447-3a7jxl34 39 23 US US NNP cord-303447-3a7jxl34 39 24 children child NNS cord-303447-3a7jxl34 39 25 and and CC cord-303447-3a7jxl34 39 26 adolescents adolescent NNS cord-303447-3a7jxl34 39 27 , , , cord-303447-3a7jxl34 39 28 regardless regardless RB cord-303447-3a7jxl34 39 29 of of IN cord-303447-3a7jxl34 39 30 health health NN cord-303447-3a7jxl34 39 31 insurance insurance NN cord-303447-3a7jxl34 39 32 status status NN cord-303447-3a7jxl34 39 33 or or CC cord-303447-3a7jxl34 39 34 income income NN cord-303447-3a7jxl34 39 35 level level NN cord-303447-3a7jxl34 39 36 , , , cord-303447-3a7jxl34 39 37 have have VBP cord-303447-3a7jxl34 39 38 access access NN cord-303447-3a7jxl34 39 39 to to IN cord-303447-3a7jxl34 39 40 recommended recommend VBN cord-303447-3a7jxl34 39 41 immunizations immunization NNS cord-303447-3a7jxl34 39 42 requires require VBZ cord-303447-3a7jxl34 39 43 a a DT cord-303447-3a7jxl34 39 44 complex complex JJ cord-303447-3a7jxl34 39 45 system system NN cord-303447-3a7jxl34 39 46 of of IN cord-303447-3a7jxl34 39 47 financing financing NN cord-303447-3a7jxl34 39 48 comprised comprise VBN cord-303447-3a7jxl34 39 49 of of IN cord-303447-3a7jxl34 39 50 private private JJ cord-303447-3a7jxl34 39 51 and and CC cord-303447-3a7jxl34 39 52 public public JJ cord-303447-3a7jxl34 39 53 funding funding NN cord-303447-3a7jxl34 39 54 mechanisms mechanism NNS cord-303447-3a7jxl34 39 55 ( ( -LRB- cord-303447-3a7jxl34 39 56 Table Table NNP cord-303447-3a7jxl34 39 57 4 4 CD cord-303447-3a7jxl34 39 58 ) ) -RRB- cord-303447-3a7jxl34 39 59 . . . cord-303447-3a7jxl34 40 1 In in IN cord-303447-3a7jxl34 40 2 2002 2002 CD cord-303447-3a7jxl34 40 3 , , , cord-303447-3a7jxl34 40 4 57 57 CD cord-303447-3a7jxl34 40 5 % % NN cord-303447-3a7jxl34 40 6 of of IN cord-303447-3a7jxl34 40 7 US US NNP cord-303447-3a7jxl34 40 8 children child NNS cord-303447-3a7jxl34 40 9 received receive VBD cord-303447-3a7jxl34 40 10 vaccines vaccine NNS cord-303447-3a7jxl34 40 11 purchased purchase VBN cord-303447-3a7jxl34 40 12 through through IN cord-303447-3a7jxl34 40 13 the the DT cord-303447-3a7jxl34 40 14 public public JJ cord-303447-3a7jxl34 40 15 sector sector NN cord-303447-3a7jxl34 40 16 , , , cord-303447-3a7jxl34 40 17 and and CC cord-303447-3a7jxl34 40 18 43 43 CD cord-303447-3a7jxl34 40 19 % % NN cord-303447-3a7jxl34 40 20 received receive VBD cord-303447-3a7jxl34 40 21 vaccines vaccine NNS cord-303447-3a7jxl34 40 22 purchased purchase VBN cord-303447-3a7jxl34 40 23 through through IN cord-303447-3a7jxl34 40 24 the the DT cord-303447-3a7jxl34 40 25 private private JJ cord-303447-3a7jxl34 40 26 sector sector NN cord-303447-3a7jxl34 40 27 . . . cord-303447-3a7jxl34 41 1 Most Most JJS cord-303447-3a7jxl34 41 2 of of IN cord-303447-3a7jxl34 41 3 the the DT cord-303447-3a7jxl34 41 4 public public JJ cord-303447-3a7jxl34 41 5 - - HYPH cord-303447-3a7jxl34 41 6 purchase purchase NN cord-303447-3a7jxl34 41 7 vaccines vaccine NNS cord-303447-3a7jxl34 41 8 are be VBP cord-303447-3a7jxl34 41 9 financed finance VBN cord-303447-3a7jxl34 41 10 through through IN cord-303447-3a7jxl34 41 11 the the DT cord-303447-3a7jxl34 41 12 Vaccines Vaccines NNPS cord-303447-3a7jxl34 41 13 for for IN cord-303447-3a7jxl34 41 14 Children child NNS cord-303447-3a7jxl34 41 15 ( ( -LRB- cord-303447-3a7jxl34 41 16 VFC VFC NNP cord-303447-3a7jxl34 41 17 ) ) -RRB- cord-303447-3a7jxl34 41 18 program program NN cord-303447-3a7jxl34 41 19 , , , cord-303447-3a7jxl34 41 20 an an DT cord-303447-3a7jxl34 41 21 entitlement entitlement NN cord-303447-3a7jxl34 41 22 program program NN cord-303447-3a7jxl34 41 23 established establish VBN cord-303447-3a7jxl34 41 24 in in IN cord-303447-3a7jxl34 41 25 1994 1994 CD cord-303447-3a7jxl34 41 26 as as IN cord-303447-3a7jxl34 41 27 part part NN cord-303447-3a7jxl34 41 28 of of IN cord-303447-3a7jxl34 41 29 the the DT cord-303447-3a7jxl34 41 30 Social Social NNP cord-303447-3a7jxl34 41 31 Security Security NNP cord-303447-3a7jxl34 41 32 Act Act NNP cord-303447-3a7jxl34 41 33 [ [ -LRB- cord-303447-3a7jxl34 41 34 11 11 CD cord-303447-3a7jxl34 41 35 , , , cord-303447-3a7jxl34 41 36 12 12 CD cord-303447-3a7jxl34 41 37 ] ] -RRB- cord-303447-3a7jxl34 41 38 . . . cord-303447-3a7jxl34 42 1 Other other JJ cord-303447-3a7jxl34 42 2 government government NN cord-303447-3a7jxl34 42 3 funding funding NN cord-303447-3a7jxl34 42 4 mechanisms mechanism NNS cord-303447-3a7jxl34 42 5 include include VBP cord-303447-3a7jxl34 42 6 Section section NN cord-303447-3a7jxl34 42 7 317 317 CD cord-303447-3a7jxl34 42 8 of of IN cord-303447-3a7jxl34 42 9 the the DT cord-303447-3a7jxl34 42 10 Public Public NNP cord-303447-3a7jxl34 42 11 Health Health NNP cord-303447-3a7jxl34 42 12 Service Service NNP cord-303447-3a7jxl34 42 13 Act Act NNP cord-303447-3a7jxl34 42 14 of of IN cord-303447-3a7jxl34 42 15 1962 1962 CD cord-303447-3a7jxl34 42 16 , , , cord-303447-3a7jxl34 42 17 a a DT cord-303447-3a7jxl34 42 18 federal federal JJ cord-303447-3a7jxl34 42 19 grant grant NN cord-303447-3a7jxl34 42 20 program program NN cord-303447-3a7jxl34 42 21 , , , cord-303447-3a7jxl34 42 22 and and CC cord-303447-3a7jxl34 42 23 state state NN cord-303447-3a7jxl34 42 24 and and CC cord-303447-3a7jxl34 42 25 local local JJ cord-303447-3a7jxl34 42 26 government government NN cord-303447-3a7jxl34 42 27 funding funding NN cord-303447-3a7jxl34 42 28 . . . cord-303447-3a7jxl34 43 1 These these DT cord-303447-3a7jxl34 43 2 programs program NNS cord-303447-3a7jxl34 43 3 provide provide VBP cord-303447-3a7jxl34 43 4 support support NN cord-303447-3a7jxl34 43 5 for for IN cord-303447-3a7jxl34 43 6 states state NNS cord-303447-3a7jxl34 43 7 to to TO cord-303447-3a7jxl34 43 8 provide provide VB cord-303447-3a7jxl34 43 9 immunizations immunization NNS cord-303447-3a7jxl34 43 10 to to IN cord-303447-3a7jxl34 43 11 children child NNS cord-303447-3a7jxl34 43 12 who who WP cord-303447-3a7jxl34 43 13 do do VBP cord-303447-3a7jxl34 43 14 not not RB cord-303447-3a7jxl34 43 15 qualify qualify VB cord-303447-3a7jxl34 43 16 for for IN cord-303447-3a7jxl34 43 17 the the DT cord-303447-3a7jxl34 43 18 VFC VFC NNP cord-303447-3a7jxl34 43 19 program program NN cord-303447-3a7jxl34 43 20 but but CC cord-303447-3a7jxl34 43 21 who who WP cord-303447-3a7jxl34 43 22 are be VBP cord-303447-3a7jxl34 43 23 not not RB cord-303447-3a7jxl34 43 24 covered cover VBN cord-303447-3a7jxl34 43 25 by by IN cord-303447-3a7jxl34 43 26 private private JJ cord-303447-3a7jxl34 43 27 insurance insurance NN cord-303447-3a7jxl34 43 28 . . . cord-303447-3a7jxl34 44 1 Fourteen fourteen CD cord-303447-3a7jxl34 44 2 states state NNS cord-303447-3a7jxl34 44 3 , , , cord-303447-3a7jxl34 44 4 referred refer VBD cord-303447-3a7jxl34 44 5 to to IN cord-303447-3a7jxl34 44 6 as as IN cord-303447-3a7jxl34 44 7 ' ' '' cord-303447-3a7jxl34 44 8 ' ' `` cord-303447-3a7jxl34 44 9 universal universal JJ cord-303447-3a7jxl34 44 10 ' ' '' cord-303447-3a7jxl34 44 11 ' ' '' cord-303447-3a7jxl34 44 12 purchase purchase NN cord-303447-3a7jxl34 44 13 states state NNS cord-303447-3a7jxl34 44 14 , , , cord-303447-3a7jxl34 44 15 use use VB cord-303447-3a7jxl34 44 16 a a DT cord-303447-3a7jxl34 44 17 combination combination NN cord-303447-3a7jxl34 44 18 of of IN cord-303447-3a7jxl34 44 19 federal federal JJ cord-303447-3a7jxl34 44 20 and and CC cord-303447-3a7jxl34 44 21 state state NN cord-303447-3a7jxl34 44 22 funding funding NN cord-303447-3a7jxl34 44 23 to to TO cord-303447-3a7jxl34 44 24 purchase purchase VB cord-303447-3a7jxl34 44 25 and and CC cord-303447-3a7jxl34 44 26 distribute distribute VB cord-303447-3a7jxl34 44 27 vaccines vaccine NNS cord-303447-3a7jxl34 44 28 recommended recommend VBN cord-303447-3a7jxl34 44 29 for for IN cord-303447-3a7jxl34 44 30 children child NNS cord-303447-3a7jxl34 44 31 to to IN cord-303447-3a7jxl34 44 32 all all DT cord-303447-3a7jxl34 44 33 immunization immunization NN cord-303447-3a7jxl34 44 34 providers provider NNS cord-303447-3a7jxl34 44 35 in in IN cord-303447-3a7jxl34 44 36 private private JJ cord-303447-3a7jxl34 44 37 and and CC cord-303447-3a7jxl34 44 38 public public JJ cord-303447-3a7jxl34 44 39 sectors sector NNS cord-303447-3a7jxl34 44 40 . . . cord-303447-3a7jxl34 45 1 The the DT cord-303447-3a7jxl34 45 2 remaining remain VBG cord-303447-3a7jxl34 45 3 36 36 CD cord-303447-3a7jxl34 45 4 states state NNS cord-303447-3a7jxl34 45 5 purchase purchase VBP cord-303447-3a7jxl34 45 6 vaccines vaccine NNS cord-303447-3a7jxl34 45 7 for for IN cord-303447-3a7jxl34 45 8 uninsured uninsured JJ cord-303447-3a7jxl34 45 9 and and CC cord-303447-3a7jxl34 45 10 underinsured underinsured JJ cord-303447-3a7jxl34 45 11 chil- chil- NN cord-303447-3a7jxl34 45 12 immunizations immunization NNS cord-303447-3a7jxl34 45 13 in in IN cord-303447-3a7jxl34 45 14 the the DT cord-303447-3a7jxl34 45 15 us us NNP cord-303447-3a7jxl34 45 16 dren dren NNP cord-303447-3a7jxl34 45 17 who who WP cord-303447-3a7jxl34 45 18 are be VBP cord-303447-3a7jxl34 45 19 not not RB cord-303447-3a7jxl34 45 20 eligible eligible JJ cord-303447-3a7jxl34 45 21 for for IN cord-303447-3a7jxl34 45 22 VFC VFC NNP cord-303447-3a7jxl34 45 23 . . . cord-303447-3a7jxl34 46 1 In in IN cord-303447-3a7jxl34 46 2 addition addition NN cord-303447-3a7jxl34 46 3 , , , cord-303447-3a7jxl34 46 4 insurance insurance NN cord-303447-3a7jxl34 46 5 provides provide VBZ cord-303447-3a7jxl34 46 6 vaccines vaccine NNS cord-303447-3a7jxl34 46 7 for for IN cord-303447-3a7jxl34 46 8 children child NNS cord-303447-3a7jxl34 46 9 in in IN cord-303447-3a7jxl34 46 10 the the DT cord-303447-3a7jxl34 46 11 private private JJ cord-303447-3a7jxl34 46 12 sector sector NN cord-303447-3a7jxl34 46 13 . . . cord-303447-3a7jxl34 47 1 As as IN cord-303447-3a7jxl34 47 2 the the DT cord-303447-3a7jxl34 47 3 number number NN cord-303447-3a7jxl34 47 4 of of IN cord-303447-3a7jxl34 47 5 vaccines vaccine NNS cord-303447-3a7jxl34 47 6 has have VBZ cord-303447-3a7jxl34 47 7 increased increase VBN cord-303447-3a7jxl34 47 8 and and CC cord-303447-3a7jxl34 47 9 the the DT cord-303447-3a7jxl34 47 10 scope scope NN cord-303447-3a7jxl34 47 11 of of IN cord-303447-3a7jxl34 47 12 the the DT cord-303447-3a7jxl34 47 13 immunization immunization NN cord-303447-3a7jxl34 47 14 program program NN cord-303447-3a7jxl34 47 15 has have VBZ cord-303447-3a7jxl34 47 16 expanded expand VBN cord-303447-3a7jxl34 47 17 , , , cord-303447-3a7jxl34 47 18 new new JJ cord-303447-3a7jxl34 47 19 challenges challenge NNS cord-303447-3a7jxl34 47 20 have have VBP cord-303447-3a7jxl34 47 21 emerged emerge VBN cord-303447-3a7jxl34 47 22 . . . cord-303447-3a7jxl34 48 1 The the DT cord-303447-3a7jxl34 48 2 increasing increase VBG cord-303447-3a7jxl34 48 3 cost cost NN cord-303447-3a7jxl34 48 4 of of IN cord-303447-3a7jxl34 48 5 vaccines vaccine NNS cord-303447-3a7jxl34 48 6 , , , cord-303447-3a7jxl34 48 7 vaccine vaccine NN cord-303447-3a7jxl34 48 8 shortages shortage NNS cord-303447-3a7jxl34 48 9 , , , cord-303447-3a7jxl34 48 10 and and CC cord-303447-3a7jxl34 48 11 immunization immunization NN cord-303447-3a7jxl34 48 12 safety safety NN cord-303447-3a7jxl34 48 13 are be VBP cord-303447-3a7jxl34 48 14 important important JJ cord-303447-3a7jxl34 48 15 concerns concern NNS cord-303447-3a7jxl34 48 16 the the DT cord-303447-3a7jxl34 48 17 immunization immunization NN cord-303447-3a7jxl34 48 18 program program NN cord-303447-3a7jxl34 48 19 will will MD cord-303447-3a7jxl34 48 20 continue continue VB cord-303447-3a7jxl34 48 21 to to TO cord-303447-3a7jxl34 48 22 address address VB cord-303447-3a7jxl34 48 23 in in IN cord-303447-3a7jxl34 48 24 coming come VBG cord-303447-3a7jxl34 48 25 years year NNS cord-303447-3a7jxl34 48 26 . . . cord-303447-3a7jxl34 49 1 The the DT cord-303447-3a7jxl34 49 2 rising rise VBG cord-303447-3a7jxl34 49 3 cost cost NN cord-303447-3a7jxl34 49 4 of of IN cord-303447-3a7jxl34 49 5 fully fully RB cord-303447-3a7jxl34 49 6 immunizing immunize VBG cord-303447-3a7jxl34 49 7 a a DT cord-303447-3a7jxl34 49 8 child child NN cord-303447-3a7jxl34 49 9 in in IN cord-303447-3a7jxl34 49 10 the the DT cord-303447-3a7jxl34 49 11 United United NNP cord-303447-3a7jxl34 49 12 States States NNP cord-303447-3a7jxl34 49 13 is be VBZ cord-303447-3a7jxl34 49 14 due due JJ cord-303447-3a7jxl34 49 15 to to IN cord-303447-3a7jxl34 49 16 the the DT cord-303447-3a7jxl34 49 17 increasing increase VBG cord-303447-3a7jxl34 49 18 number number NN cord-303447-3a7jxl34 49 19 of of IN cord-303447-3a7jxl34 49 20 vaccines vaccine NNS cord-303447-3a7jxl34 49 21 and and CC cord-303447-3a7jxl34 49 22 the the DT cord-303447-3a7jxl34 49 23 increasing increase VBG cord-303447-3a7jxl34 49 24 price price NN cord-303447-3a7jxl34 49 25 of of IN cord-303447-3a7jxl34 49 26 existing exist VBG cord-303447-3a7jxl34 49 27 vaccines vaccine NNS cord-303447-3a7jxl34 49 28 . . . cord-303447-3a7jxl34 50 1 The the DT cord-303447-3a7jxl34 50 2 estimated estimate VBN cord-303447-3a7jxl34 50 3 cost cost NN cord-303447-3a7jxl34 50 4 of of IN cord-303447-3a7jxl34 50 5 completing complete VBG cord-303447-3a7jxl34 50 6 the the DT cord-303447-3a7jxl34 50 7 childhood childhood NN cord-303447-3a7jxl34 50 8 immunization immunization NN cord-303447-3a7jxl34 50 9 series series NN cord-303447-3a7jxl34 50 10 through through IN cord-303447-3a7jxl34 50 11 6 6 CD cord-303447-3a7jxl34 50 12 years year NNS cord-303447-3a7jxl34 50 13 of of IN cord-303447-3a7jxl34 50 14 age age NN cord-303447-3a7jxl34 50 15 in in IN cord-303447-3a7jxl34 50 16 1987 1987 CD cord-303447-3a7jxl34 50 17 was be VBD cord-303447-3a7jxl34 50 18 $ $ $ cord-303447-3a7jxl34 50 19 33.70 33.70 CD cord-303447-3a7jxl34 50 20 per per IN cord-303447-3a7jxl34 50 21 child child NN cord-303447-3a7jxl34 50 22 at at IN cord-303447-3a7jxl34 50 23 the the DT cord-303447-3a7jxl34 50 24 government government NN cord-303447-3a7jxl34 50 25 - - HYPH cord-303447-3a7jxl34 50 26 purchasing purchasing NN cord-303447-3a7jxl34 50 27 rate rate NN cord-303447-3a7jxl34 50 28 . . . cord-303447-3a7jxl34 51 1 The the DT cord-303447-3a7jxl34 51 2 cost cost NN cord-303447-3a7jxl34 51 3 of of IN cord-303447-3a7jxl34 51 4 immunizing immunize VBG cord-303447-3a7jxl34 51 5 a a DT cord-303447-3a7jxl34 51 6 child child NN cord-303447-3a7jxl34 51 7 through through IN cord-303447-3a7jxl34 51 8 6 6 CD cord-303447-3a7jxl34 51 9 years year NNS cord-303447-3a7jxl34 51 10 of of IN cord-303447-3a7jxl34 51 11 age age NN cord-303447-3a7jxl34 51 12 in in IN cord-303447-3a7jxl34 51 13 2003 2003 CD cord-303447-3a7jxl34 51 14 was be VBD cord-303447-3a7jxl34 51 15 $ $ $ cord-303447-3a7jxl34 51 16 436 436 CD cord-303447-3a7jxl34 51 17 per per IN cord-303447-3a7jxl34 51 18 child child NN cord-303447-3a7jxl34 51 19 for for IN cord-303447-3a7jxl34 51 20 all all DT cord-303447-3a7jxl34 51 21 vaccines vaccine NNS cord-303447-3a7jxl34 51 22 , , , cord-303447-3a7jxl34 51 23 not not RB cord-303447-3a7jxl34 51 24 including include VBG cord-303447-3a7jxl34 51 25 influenza influenza NN cord-303447-3a7jxl34 51 26 vaccine vaccine NN cord-303447-3a7jxl34 51 27 [ [ -LRB- cord-303447-3a7jxl34 51 28 12 12 CD cord-303447-3a7jxl34 51 29 ] ] -RRB- cord-303447-3a7jxl34 51 30 . . . cord-303447-3a7jxl34 52 1 Increasingly increasingly RB cord-303447-3a7jxl34 52 2 , , , cord-303447-3a7jxl34 52 3 state state NN cord-303447-3a7jxl34 52 4 and and CC cord-303447-3a7jxl34 52 5 local local JJ cord-303447-3a7jxl34 52 6 health health NN cord-303447-3a7jxl34 52 7 departments department NNS cord-303447-3a7jxl34 52 8 are be VBP cord-303447-3a7jxl34 52 9 required require VBN cord-303447-3a7jxl34 52 10 to to TO cord-303447-3a7jxl34 52 11 make make VB cord-303447-3a7jxl34 52 12 difficult difficult JJ cord-303447-3a7jxl34 52 13 choices choice NNS cord-303447-3a7jxl34 52 14 about about IN cord-303447-3a7jxl34 52 15 which which WDT cord-303447-3a7jxl34 52 16 vaccines vaccine NNS cord-303447-3a7jxl34 52 17 to to TO cord-303447-3a7jxl34 52 18 purchase purchase VB cord-303447-3a7jxl34 52 19 using use VBG cord-303447-3a7jxl34 52 20 public public JJ cord-303447-3a7jxl34 52 21 funds fund NNS cord-303447-3a7jxl34 52 22 , , , cord-303447-3a7jxl34 52 23 including include VBG cord-303447-3a7jxl34 52 24 Section section NN cord-303447-3a7jxl34 52 25 317 317 CD cord-303447-3a7jxl34 52 26 grant grant NN cord-303447-3a7jxl34 52 27 funds fund NNS cord-303447-3a7jxl34 52 28 . . . cord-303447-3a7jxl34 53 1 The the DT cord-303447-3a7jxl34 53 2 recommendation recommendation NN cord-303447-3a7jxl34 53 3 in in IN cord-303447-3a7jxl34 53 4 2000 2000 CD cord-303447-3a7jxl34 53 5 to to TO cord-303447-3a7jxl34 53 6 vaccinate vaccinate VB cord-303447-3a7jxl34 53 7 routinely routinely RB cord-303447-3a7jxl34 53 8 with with IN cord-303447-3a7jxl34 53 9 PCV7 PCV7 NNP cord-303447-3a7jxl34 53 10 doubled double VBD cord-303447-3a7jxl34 53 11 the the DT cord-303447-3a7jxl34 53 12 cost cost NN cord-303447-3a7jxl34 53 13 of of IN cord-303447-3a7jxl34 53 14 immunizing immunize VBG cord-303447-3a7jxl34 53 15 a a DT cord-303447-3a7jxl34 53 16 child child NN cord-303447-3a7jxl34 53 17 . . . cord-303447-3a7jxl34 54 1 Section section NN cord-303447-3a7jxl34 54 2 317 317 CD cord-303447-3a7jxl34 54 3 and and CC cord-303447-3a7jxl34 54 4 state state NN cord-303447-3a7jxl34 54 5 funding funding NN cord-303447-3a7jxl34 54 6 have have VBP cord-303447-3a7jxl34 54 7 not not RB cord-303447-3a7jxl34 54 8 been be VBN cord-303447-3a7jxl34 54 9 adequate adequate JJ cord-303447-3a7jxl34 54 10 to to TO cord-303447-3a7jxl34 54 11 cover cover VB cord-303447-3a7jxl34 54 12 PCV7 PCV7 NNP cord-303447-3a7jxl34 54 13 for for IN cord-303447-3a7jxl34 54 14 underinsured underinsured JJ cord-303447-3a7jxl34 54 15 children child NNS cord-303447-3a7jxl34 54 16 in in IN cord-303447-3a7jxl34 54 17 many many JJ cord-303447-3a7jxl34 54 18 states state NNS cord-303447-3a7jxl34 54 19 , , , cord-303447-3a7jxl34 54 20 including include VBG cord-303447-3a7jxl34 54 21 7 7 CD cord-303447-3a7jxl34 54 22 of of IN cord-303447-3a7jxl34 54 23 the the DT cord-303447-3a7jxl34 54 24 14 14 CD cord-303447-3a7jxl34 54 25 universal universal JJ cord-303447-3a7jxl34 54 26 purchase purchase NN cord-303447-3a7jxl34 54 27 states state NNS cord-303447-3a7jxl34 54 28 . . . cord-303447-3a7jxl34 55 1 The the DT cord-303447-3a7jxl34 55 2 addition addition NN cord-303447-3a7jxl34 55 3 of of IN cord-303447-3a7jxl34 55 4 new new JJ cord-303447-3a7jxl34 55 5 , , , cord-303447-3a7jxl34 55 6 effective effective JJ cord-303447-3a7jxl34 55 7 childhood childhood NN cord-303447-3a7jxl34 55 8 and and CC cord-303447-3a7jxl34 55 9 adolescent adolescent JJ cord-303447-3a7jxl34 55 10 vaccines vaccine NNS cord-303447-3a7jxl34 55 11 to to IN cord-303447-3a7jxl34 55 12 the the DT cord-303447-3a7jxl34 55 13 schedule schedule NN cord-303447-3a7jxl34 55 14 has have VBZ cord-303447-3a7jxl34 55 15 the the DT cord-303447-3a7jxl34 55 16 potential potential NN cord-303447-3a7jxl34 55 17 to to TO cord-303447-3a7jxl34 55 18 create create VB cord-303447-3a7jxl34 55 19 serious serious JJ cord-303447-3a7jxl34 55 20 funding funding NN cord-303447-3a7jxl34 55 21 challenges challenge NNS cord-303447-3a7jxl34 55 22 in in IN cord-303447-3a7jxl34 55 23 the the DT cord-303447-3a7jxl34 55 24 future future NN cord-303447-3a7jxl34 55 25 . . . cord-303447-3a7jxl34 56 1 Despite despite IN cord-303447-3a7jxl34 56 2 the the DT cord-303447-3a7jxl34 56 3 increasing increase VBG cord-303447-3a7jxl34 56 4 costs cost NNS cord-303447-3a7jxl34 56 5 of of IN cord-303447-3a7jxl34 56 6 immunization immunization NN cord-303447-3a7jxl34 56 7 programs program NNS cord-303447-3a7jxl34 56 8 , , , cord-303447-3a7jxl34 56 9 numerous numerous JJ cord-303447-3a7jxl34 56 10 studies study NNS cord-303447-3a7jxl34 56 11 have have VBP cord-303447-3a7jxl34 56 12 shown show VBN cord-303447-3a7jxl34 56 13 that that IN cord-303447-3a7jxl34 56 14 vaccination vaccination NN cord-303447-3a7jxl34 56 15 continues continue VBZ cord-303447-3a7jxl34 56 16 to to TO cord-303447-3a7jxl34 56 17 be be VB cord-303447-3a7jxl34 56 18 a a DT cord-303447-3a7jxl34 56 19 cost cost NN cord-303447-3a7jxl34 56 20 - - HYPH cord-303447-3a7jxl34 56 21 effective effective JJ cord-303447-3a7jxl34 56 22 public public JJ cord-303447-3a7jxl34 56 23 health health NN cord-303447-3a7jxl34 56 24 intervention intervention NN cord-303447-3a7jxl34 56 25 . . . cord-303447-3a7jxl34 57 1 These these DT cord-303447-3a7jxl34 57 2 studies study NNS cord-303447-3a7jxl34 57 3 show show VBP cord-303447-3a7jxl34 57 4 the the DT cord-303447-3a7jxl34 57 5 need need NN cord-303447-3a7jxl34 57 6 to to TO cord-303447-3a7jxl34 57 7 continue continue VB cord-303447-3a7jxl34 57 8 to to TO cord-303447-3a7jxl34 57 9 identify identify VB cord-303447-3a7jxl34 57 10 adequate adequate JJ cord-303447-3a7jxl34 57 11 funding funding NN cord-303447-3a7jxl34 57 12 sources source NNS cord-303447-3a7jxl34 57 13 to to TO cord-303447-3a7jxl34 57 14 support support VB cord-303447-3a7jxl34 57 15 immunization immunization NN cord-303447-3a7jxl34 57 16 recommendations recommendation NNS cord-303447-3a7jxl34 57 17 [ [ -LRB- cord-303447-3a7jxl34 57 18 13 13 CD cord-303447-3a7jxl34 57 19 ] ] -RRB- cord-303447-3a7jxl34 57 20 [ [ -LRB- cord-303447-3a7jxl34 57 21 14 14 CD cord-303447-3a7jxl34 57 22 ] ] -RRB- cord-303447-3a7jxl34 57 23 [ [ -LRB- cord-303447-3a7jxl34 57 24 15 15 CD cord-303447-3a7jxl34 57 25 ] ] -RRB- cord-303447-3a7jxl34 57 26 [ [ -LRB- cord-303447-3a7jxl34 57 27 16 16 CD cord-303447-3a7jxl34 57 28 ] ] -RRB- cord-303447-3a7jxl34 57 29 . . . cord-303447-3a7jxl34 58 1 An an DT cord-303447-3a7jxl34 58 2 Institute Institute NNP cord-303447-3a7jxl34 58 3 of of IN cord-303447-3a7jxl34 58 4 Medicine Medicine NNP cord-303447-3a7jxl34 58 5 ( ( -LRB- cord-303447-3a7jxl34 58 6 IOM IOM NNP cord-303447-3a7jxl34 58 7 ) ) -RRB- cord-303447-3a7jxl34 58 8 report report NN cord-303447-3a7jxl34 58 9 on on IN cord-303447-3a7jxl34 58 10 vaccine vaccine NN cord-303447-3a7jxl34 58 11 financing financing NN cord-303447-3a7jxl34 58 12 released release VBN cord-303447-3a7jxl34 58 13 in in IN cord-303447-3a7jxl34 58 14 2004 2004 CD cord-303447-3a7jxl34 58 15 concluded conclude VBD cord-303447-3a7jxl34 58 16 , , , cord-303447-3a7jxl34 58 17 ' ' '' cord-303447-3a7jxl34 58 18 ' ' '' cord-303447-3a7jxl34 58 19 alternatives alternative NNS cord-303447-3a7jxl34 58 20 to to IN cord-303447-3a7jxl34 58 21 current current JJ cord-303447-3a7jxl34 58 22 vaccine vaccine NN cord-303447-3a7jxl34 58 23 pricing pricing NN cord-303447-3a7jxl34 58 24 and and CC cord-303447-3a7jxl34 58 25 purchasing purchasing NN cord-303447-3a7jxl34 58 26 programs program NNS cord-303447-3a7jxl34 58 27 are be VBP cord-303447-3a7jxl34 58 28 required require VBN cord-303447-3a7jxl34 58 29 to to TO cord-303447-3a7jxl34 58 30 sustain sustain VB cord-303447-3a7jxl34 58 31 stable stable JJ cord-303447-3a7jxl34 58 32 investment investment NN cord-303447-3a7jxl34 58 33 in in IN cord-303447-3a7jxl34 58 34 development development NN cord-303447-3a7jxl34 58 35 of of IN cord-303447-3a7jxl34 58 36 new new JJ cord-303447-3a7jxl34 58 37 vaccine vaccine NN cord-303447-3a7jxl34 58 38 products product NNS cord-303447-3a7jxl34 58 39 and and CC cord-303447-3a7jxl34 58 40 attain attain VB cord-303447-3a7jxl34 58 41 their -PRON- PRP$ cord-303447-3a7jxl34 58 42 social social JJ cord-303447-3a7jxl34 58 43 benefits benefit NNS cord-303447-3a7jxl34 58 44 for for IN cord-303447-3a7jxl34 58 45 all all DT cord-303447-3a7jxl34 58 46 ' ' '' cord-303447-3a7jxl34 58 47 ' ' '' cord-303447-3a7jxl34 58 48 [ [ -LRB- cord-303447-3a7jxl34 58 49 17 17 CD cord-303447-3a7jxl34 58 50 ] ] -RRB- cord-303447-3a7jxl34 58 51 . . . cord-303447-3a7jxl34 59 1 In in IN cord-303447-3a7jxl34 59 2 addition addition NN cord-303447-3a7jxl34 59 3 to to IN cord-303447-3a7jxl34 59 4 the the DT cord-303447-3a7jxl34 59 5 increasing increase VBG cord-303447-3a7jxl34 59 6 cost cost NN cord-303447-3a7jxl34 59 7 of of IN cord-303447-3a7jxl34 59 8 vaccines vaccine NNS cord-303447-3a7jxl34 59 9 , , , cord-303447-3a7jxl34 59 10 an an DT cord-303447-3a7jxl34 59 11 unparalleled unparalleled JJ cord-303447-3a7jxl34 59 12 number number NN cord-303447-3a7jxl34 59 13 of of IN cord-303447-3a7jxl34 59 14 vaccine vaccine NN cord-303447-3a7jxl34 59 15 shortages shortage NNS cord-303447-3a7jxl34 59 16 in in IN cord-303447-3a7jxl34 59 17 the the DT cord-303447-3a7jxl34 59 18 United United NNP cord-303447-3a7jxl34 59 19 States States NNP cord-303447-3a7jxl34 59 20 has have VBZ cord-303447-3a7jxl34 59 21 had have VBN cord-303447-3a7jxl34 59 22 a a DT cord-303447-3a7jxl34 59 23 substantial substantial JJ cord-303447-3a7jxl34 59 24 impact impact NN cord-303447-3a7jxl34 59 25 on on IN cord-303447-3a7jxl34 59 26 vaccine vaccine NN cord-303447-3a7jxl34 59 27 delivery delivery NN cord-303447-3a7jxl34 59 28 . . . cord-303447-3a7jxl34 60 1 From from IN cord-303447-3a7jxl34 60 2 2000 2000 CD cord-303447-3a7jxl34 60 3 through through IN cord-303447-3a7jxl34 60 4 2005 2005 CD cord-303447-3a7jxl34 60 5 , , , cord-303447-3a7jxl34 60 6 vaccine vaccine NN cord-303447-3a7jxl34 60 7 shortages shortage NNS cord-303447-3a7jxl34 60 8 and and CC cord-303447-3a7jxl34 60 9 changes change NNS cord-303447-3a7jxl34 60 10 in in IN cord-303447-3a7jxl34 60 11 routine routine JJ cord-303447-3a7jxl34 60 12 recommendations recommendation NNS cord-303447-3a7jxl34 60 13 occurred occur VBD cord-303447-3a7jxl34 60 14 for for IN cord-303447-3a7jxl34 60 15 9 9 CD cord-303447-3a7jxl34 60 16 of of IN cord-303447-3a7jxl34 60 17 the the DT cord-303447-3a7jxl34 60 18 12 12 CD cord-303447-3a7jxl34 60 19 diseases disease NNS cord-303447-3a7jxl34 60 20 for for IN cord-303447-3a7jxl34 60 21 which which WDT cord-303447-3a7jxl34 60 22 childhood childhood NN cord-303447-3a7jxl34 60 23 and and CC cord-303447-3a7jxl34 60 24 adolescent adolescent JJ cord-303447-3a7jxl34 60 25 vaccination vaccination NN cord-303447-3a7jxl34 60 26 is be VBZ cord-303447-3a7jxl34 60 27 recommended recommend VBN cord-303447-3a7jxl34 60 28 ( ( -LRB- cord-303447-3a7jxl34 60 29 Fig Fig NNP cord-303447-3a7jxl34 60 30 . . NNP cord-303447-3a7jxl34 60 31 2 2 LS cord-303447-3a7jxl34 60 32 ) ) -RRB- cord-303447-3a7jxl34 60 33 [ [ -LRB- cord-303447-3a7jxl34 60 34 18 18 CD cord-303447-3a7jxl34 60 35 ] ] -RRB- cord-303447-3a7jxl34 60 36 [ [ -LRB- cord-303447-3a7jxl34 60 37 19 19 CD cord-303447-3a7jxl34 60 38 ] ] -RRB- cord-303447-3a7jxl34 61 1 [ [ -LRB- cord-303447-3a7jxl34 61 2 20 20 CD cord-303447-3a7jxl34 61 3 ] ] -RRB- cord-303447-3a7jxl34 61 4 [ [ -LRB- cord-303447-3a7jxl34 61 5 21 21 CD cord-303447-3a7jxl34 61 6 ] ] -RRB- cord-303447-3a7jxl34 62 1 [ [ -LRB- cord-303447-3a7jxl34 62 2 22 22 CD cord-303447-3a7jxl34 62 3 ] ] -RRB- cord-303447-3a7jxl34 62 4 [ [ -LRB- cord-303447-3a7jxl34 62 5 23 23 CD cord-303447-3a7jxl34 62 6 ] ] -RRB- cord-303447-3a7jxl34 62 7 . . . cord-303447-3a7jxl34 63 1 The the DT cord-303447-3a7jxl34 63 2 shortages shortage NNS cord-303447-3a7jxl34 63 3 affected affect VBD cord-303447-3a7jxl34 63 4 millions million NNS cord-303447-3a7jxl34 63 5 of of IN cord-303447-3a7jxl34 63 6 children child NNS cord-303447-3a7jxl34 63 7 and and CC cord-303447-3a7jxl34 63 8 health health NN cord-303447-3a7jxl34 63 9 care care NN cord-303447-3a7jxl34 63 10 providers provider NNS cord-303447-3a7jxl34 63 11 , , , cord-303447-3a7jxl34 63 12 even even RB cord-303447-3a7jxl34 63 13 triggering trigger VBG cord-303447-3a7jxl34 63 14 suspension suspension NN cord-303447-3a7jxl34 63 15 of of IN cord-303447-3a7jxl34 63 16 vaccine vaccine NN cord-303447-3a7jxl34 63 17 school school NN cord-303447-3a7jxl34 63 18 entry entry NN cord-303447-3a7jxl34 63 19 requirements requirement NNS cord-303447-3a7jxl34 63 20 [ [ -LRB- cord-303447-3a7jxl34 63 21 24 24 CD cord-303447-3a7jxl34 63 22 , , , cord-303447-3a7jxl34 63 23 25 25 CD cord-303447-3a7jxl34 63 24 ] ] -RRB- cord-303447-3a7jxl34 63 25 . . . cord-303447-3a7jxl34 64 1 Two two CD cord-303447-3a7jxl34 64 2 vaccine vaccine NN cord-303447-3a7jxl34 64 3 shortages shortage NNS cord-303447-3a7jxl34 64 4 ( ( -LRB- cord-303447-3a7jxl34 64 5 PCV7 PCV7 NNP cord-303447-3a7jxl34 64 6 and and CC cord-303447-3a7jxl34 64 7 tetanus tetanus NN cord-303447-3a7jxl34 64 8 and and CC cord-303447-3a7jxl34 64 9 diphtheria diphtheria NN cord-303447-3a7jxl34 64 10 toxoids toxoid NNS cord-303447-3a7jxl34 64 11 [ [ -LRB- cord-303447-3a7jxl34 64 12 Td Td NNP cord-303447-3a7jxl34 64 13 ] ] -RRB- cord-303447-3a7jxl34 64 14 ) ) -RRB- cord-303447-3a7jxl34 64 15 lasted last VBD cord-303447-3a7jxl34 64 16 nearly nearly RB cord-303447-3a7jxl34 64 17 2 2 CD cord-303447-3a7jxl34 64 18 years year NNS cord-303447-3a7jxl34 64 19 , , , cord-303447-3a7jxl34 64 20 one one CD cord-303447-3a7jxl34 64 21 ( ( -LRB- cord-303447-3a7jxl34 64 22 PCV7 PCV7 NNP cord-303447-3a7jxl34 64 23 ) ) -RRB- cord-303447-3a7jxl34 64 24 occurred occur VBD cord-303447-3a7jxl34 64 25 twice twice RB cord-303447-3a7jxl34 64 26 [ [ -LRB- cord-303447-3a7jxl34 64 27 26 26 CD cord-303447-3a7jxl34 64 28 ] ] -RRB- cord-303447-3a7jxl34 64 29 , , , cord-303447-3a7jxl34 64 30 and and CC cord-303447-3a7jxl34 64 31 one one CD cord-303447-3a7jxl34 64 32 ( ( -LRB- cord-303447-3a7jxl34 64 33 inactivated inactivate VBN cord-303447-3a7jxl34 64 34 influenza influenza NN cord-303447-3a7jxl34 64 35 vaccine vaccine NN cord-303447-3a7jxl34 64 36 , , , cord-303447-3a7jxl34 64 37 2004 2004 CD cord-303447-3a7jxl34 64 38 - - SYM cord-303447-3a7jxl34 64 39 05 05 CD cord-303447-3a7jxl34 64 40 season season NN cord-303447-3a7jxl34 64 41 ) ) -RRB- cord-303447-3a7jxl34 64 42 halved halve VBD cord-303447-3a7jxl34 64 43 the the DT cord-303447-3a7jxl34 64 44 US US NNP cord-303447-3a7jxl34 64 45 influenza influenza NN cord-303447-3a7jxl34 64 46 vaccine vaccine NN cord-303447-3a7jxl34 64 47 supply supply NN cord-303447-3a7jxl34 64 48 virtually virtually RB cord-303447-3a7jxl34 64 49 overnight overnight RB cord-303447-3a7jxl34 64 50 [ [ -LRB- cord-303447-3a7jxl34 64 51 17 17 CD cord-303447-3a7jxl34 64 52 , , , cord-303447-3a7jxl34 64 53 22 22 CD cord-303447-3a7jxl34 64 54 ] ] -RRB- cord-303447-3a7jxl34 64 55 . . . cord-303447-3a7jxl34 65 1 The the DT cord-303447-3a7jxl34 65 2 causes cause NNS cord-303447-3a7jxl34 65 3 of of IN cord-303447-3a7jxl34 65 4 these these DT cord-303447-3a7jxl34 65 5 widespread widespread JJ cord-303447-3a7jxl34 65 6 vaccine vaccine NN cord-303447-3a7jxl34 65 7 shortages shortage NNS cord-303447-3a7jxl34 65 8 are be VBP cord-303447-3a7jxl34 65 9 multifactorial multifactorial JJ cord-303447-3a7jxl34 65 10 . . . cord-303447-3a7jxl34 66 1 One one CD cord-303447-3a7jxl34 66 2 important important JJ cord-303447-3a7jxl34 66 3 long long JJ cord-303447-3a7jxl34 66 4 - - HYPH cord-303447-3a7jxl34 66 5 term term NN cord-303447-3a7jxl34 66 6 factor factor NN cord-303447-3a7jxl34 66 7 is be VBZ cord-303447-3a7jxl34 66 8 the the DT cord-303447-3a7jxl34 66 9 decrease decrease NN cord-303447-3a7jxl34 66 10 in in IN cord-303447-3a7jxl34 66 11 number number NN cord-303447-3a7jxl34 66 12 of of IN cord-303447-3a7jxl34 66 13 vaccine vaccine NN cord-303447-3a7jxl34 66 14 manufacturers manufacturer NNS cord-303447-3a7jxl34 66 15 of of IN cord-303447-3a7jxl34 66 16 childhood childhood NN cord-303447-3a7jxl34 66 17 vaccines vaccine NNS cord-303447-3a7jxl34 66 18 routinely routinely RB cord-303447-3a7jxl34 66 19 recommended recommend VBN cord-303447-3a7jxl34 66 20 in in IN cord-303447-3a7jxl34 66 21 the the DT cord-303447-3a7jxl34 66 22 United United NNP cord-303447-3a7jxl34 66 23 States States NNP cord-303447-3a7jxl34 66 24 . . . cord-303447-3a7jxl34 67 1 In in IN cord-303447-3a7jxl34 67 2 1977 1977 CD cord-303447-3a7jxl34 67 3 , , , cord-303447-3a7jxl34 67 4 a a DT cord-303447-3a7jxl34 67 5 federal federal JJ cord-303447-3a7jxl34 67 6 immunization immunization NN cord-303447-3a7jxl34 67 7 working working NN cord-303447-3a7jxl34 67 8 group group NN cord-303447-3a7jxl34 67 9 expressed express VBD cord-303447-3a7jxl34 67 10 concern concern NN cord-303447-3a7jxl34 67 11 about about IN cord-303447-3a7jxl34 67 12 the the DT cord-303447-3a7jxl34 67 13 stability stability NN cord-303447-3a7jxl34 67 14 of of IN cord-303447-3a7jxl34 67 15 the the DT cord-303447-3a7jxl34 67 16 US US NNP cord-303447-3a7jxl34 67 17 vaccine vaccine NN cord-303447-3a7jxl34 67 18 supply supply NN cord-303447-3a7jxl34 67 19 in in IN cord-303447-3a7jxl34 67 20 the the DT cord-303447-3a7jxl34 67 21 setting setting NN cord-303447-3a7jxl34 67 22 of of IN cord-303447-3a7jxl34 67 23 ' ' `` cord-303447-3a7jxl34 67 24 ' ' '' cord-303447-3a7jxl34 67 25 a a DT cord-303447-3a7jxl34 67 26 steady steady JJ cord-303447-3a7jxl34 67 27 attrition attrition NN cord-303447-3a7jxl34 67 28 of of IN cord-303447-3a7jxl34 67 29 specific specific JJ cord-303447-3a7jxl34 67 30 pharmaceutical pharmaceutical JJ cord-303447-3a7jxl34 67 31 manufacturers manufacturer NNS cord-303447-3a7jxl34 67 32 from from IN cord-303447-3a7jxl34 67 33 the the DT cord-303447-3a7jxl34 67 34 entire entire JJ cord-303447-3a7jxl34 67 35 field field NN cord-303447-3a7jxl34 67 36 of of IN cord-303447-3a7jxl34 67 37 biologics biologic NNS cord-303447-3a7jxl34 67 38 ' ' POS cord-303447-3a7jxl34 67 39 ' ' '' cord-303447-3a7jxl34 67 40 [ [ -LRB- cord-303447-3a7jxl34 67 41 17 17 CD cord-303447-3a7jxl34 67 42 ] ] -RRB- cord-303447-3a7jxl34 67 43 . . . cord-303447-3a7jxl34 68 1 In in IN cord-303447-3a7jxl34 68 2 1993 1993 CD cord-303447-3a7jxl34 68 3 , , , cord-303447-3a7jxl34 68 4 six six CD cord-303447-3a7jxl34 68 5 manufactures manufacture NNS cord-303447-3a7jxl34 68 6 produced produce VBD cord-303447-3a7jxl34 68 7 the the DT cord-303447-3a7jxl34 68 8 six six CD cord-303447-3a7jxl34 68 9 vaccines vaccine NNS cord-303447-3a7jxl34 68 10 . . . cord-303447-3a7jxl34 69 1 In in IN cord-303447-3a7jxl34 69 2 2005 2005 CD cord-303447-3a7jxl34 69 3 , , , cord-303447-3a7jxl34 69 4 although although IN cord-303447-3a7jxl34 69 5 four four CD cord-303447-3a7jxl34 69 6 vaccines vaccine NNS cord-303447-3a7jxl34 69 7 ( ( -LRB- cord-303447-3a7jxl34 69 8 PCV7 PCV7 NNP cord-303447-3a7jxl34 69 9 , , , cord-303447-3a7jxl34 69 10 varicella varicella NN cord-303447-3a7jxl34 69 11 , , , cord-303447-3a7jxl34 69 12 influenza influenza NN cord-303447-3a7jxl34 69 13 , , , cord-303447-3a7jxl34 69 14 and and CC cord-303447-3a7jxl34 69 15 MCV4 MCV4 NNP cord-303447-3a7jxl34 69 16 ) ) -RRB- cord-303447-3a7jxl34 69 17 have have VBP cord-303447-3a7jxl34 69 18 been be VBN cord-303447-3a7jxl34 69 19 added add VBN cord-303447-3a7jxl34 69 20 to to IN cord-303447-3a7jxl34 69 21 the the DT cord-303447-3a7jxl34 69 22 recommended recommend VBN cord-303447-3a7jxl34 69 23 schedule schedule NN cord-303447-3a7jxl34 69 24 , , , cord-303447-3a7jxl34 69 25 the the DT cord-303447-3a7jxl34 69 26 number number NN cord-303447-3a7jxl34 69 27 of of IN cord-303447-3a7jxl34 69 28 manufacturers manufacturer NNS cord-303447-3a7jxl34 69 29 decreased decrease VBD cord-303447-3a7jxl34 69 30 to to IN cord-303447-3a7jxl34 69 31 five five CD cord-303447-3a7jxl34 69 32 . . . cord-303447-3a7jxl34 70 1 In in IN cord-303447-3a7jxl34 70 2 addition addition NN cord-303447-3a7jxl34 70 3 , , , cord-303447-3a7jxl34 70 4 there there EX cord-303447-3a7jxl34 70 5 are be VBP cord-303447-3a7jxl34 70 6 single single JJ cord-303447-3a7jxl34 70 7 manufacturers manufacturer NNS cord-303447-3a7jxl34 70 8 for for IN cord-303447-3a7jxl34 70 9 four four CD cord-303447-3a7jxl34 70 10 of of IN cord-303447-3a7jxl34 70 11 the the DT cord-303447-3a7jxl34 70 12 childhood childhood NN cord-303447-3a7jxl34 70 13 and and CC cord-303447-3a7jxl34 70 14 adolescent adolescent JJ cord-303447-3a7jxl34 70 15 vaccines vaccine NNS cord-303447-3a7jxl34 70 16 ( ( -LRB- cord-303447-3a7jxl34 70 17 MMR MMR NNP cord-303447-3a7jxl34 70 18 , , , cord-303447-3a7jxl34 70 19 varicella varicella NN cord-303447-3a7jxl34 70 20 , , , cord-303447-3a7jxl34 70 21 PCV7 PCV7 NNP cord-303447-3a7jxl34 70 22 , , , cord-303447-3a7jxl34 70 23 and and CC cord-303447-3a7jxl34 70 24 MCV4 MCV4 NNP cord-303447-3a7jxl34 70 25 ) ) -RRB- cord-303447-3a7jxl34 70 26 . . . cord-303447-3a7jxl34 71 1 In in IN cord-303447-3a7jxl34 71 2 response response NN cord-303447-3a7jxl34 71 3 to to IN cord-303447-3a7jxl34 71 4 concerns concern NNS cord-303447-3a7jxl34 71 5 over over IN cord-303447-3a7jxl34 71 6 fragility fragility NN cord-303447-3a7jxl34 71 7 of of IN cord-303447-3a7jxl34 71 8 the the DT cord-303447-3a7jxl34 71 9 US US NNP cord-303447-3a7jxl34 71 10 vaccine vaccine NN cord-303447-3a7jxl34 71 11 supply supply NN cord-303447-3a7jxl34 71 12 , , , cord-303447-3a7jxl34 71 13 the the DT cord-303447-3a7jxl34 71 14 General General NNP cord-303447-3a7jxl34 71 15 Accounting Accounting NNP cord-303447-3a7jxl34 71 16 Office Office NNP cord-303447-3a7jxl34 71 17 and and CC cord-303447-3a7jxl34 71 18 National National NNP cord-303447-3a7jxl34 71 19 Vaccine Vaccine NNP cord-303447-3a7jxl34 71 20 Advisory Advisory NNP cord-303447-3a7jxl34 71 21 Committee Committee NNP cord-303447-3a7jxl34 71 22 conducted conduct VBD cord-303447-3a7jxl34 71 23 in in IN cord-303447-3a7jxl34 71 24 - - HYPH cord-303447-3a7jxl34 71 25 depth depth NN cord-303447-3a7jxl34 71 26 reviews review NNS cord-303447-3a7jxl34 71 27 of of IN cord-303447-3a7jxl34 71 28 the the DT cord-303447-3a7jxl34 71 29 vaccine vaccine NN cord-303447-3a7jxl34 71 30 shortages shortage NNS cord-303447-3a7jxl34 71 31 and and CC cord-303447-3a7jxl34 71 32 concluded conclude VBD cord-303447-3a7jxl34 71 33 that that IN cord-303447-3a7jxl34 71 34 future future JJ cord-303447-3a7jxl34 71 35 disruptions disruption NNS cord-303447-3a7jxl34 71 36 in in IN cord-303447-3a7jxl34 71 37 vaccine vaccine NN cord-303447-3a7jxl34 71 38 supply supply NN cord-303447-3a7jxl34 71 39 are be VBP cord-303447-3a7jxl34 71 40 likely likely JJ cord-303447-3a7jxl34 71 41 to to TO cord-303447-3a7jxl34 71 42 continue continue VB cord-303447-3a7jxl34 71 43 , , , cord-303447-3a7jxl34 71 44 and and CC cord-303447-3a7jxl34 71 45 proposed propose VBN cord-303447-3a7jxl34 71 46 solutions solution NNS cord-303447-3a7jxl34 71 47 [ [ -LRB- cord-303447-3a7jxl34 71 48 17 17 CD cord-303447-3a7jxl34 71 49 , , , cord-303447-3a7jxl34 71 50 27 27 CD cord-303447-3a7jxl34 71 51 ] ] -RRB- cord-303447-3a7jxl34 71 52 . . . cord-303447-3a7jxl34 72 1 Vaccines vaccine NNS cord-303447-3a7jxl34 72 2 are be VBP cord-303447-3a7jxl34 72 3 administered administer VBN cord-303447-3a7jxl34 72 4 routinely routinely RB cord-303447-3a7jxl34 72 5 to to IN cord-303447-3a7jxl34 72 6 healthy healthy JJ cord-303447-3a7jxl34 72 7 children child NNS cord-303447-3a7jxl34 72 8 and and CC cord-303447-3a7jxl34 72 9 must must MD cord-303447-3a7jxl34 72 10 uphold uphold VB cord-303447-3a7jxl34 72 11 a a DT cord-303447-3a7jxl34 72 12 scrupulously scrupulously RB cord-303447-3a7jxl34 72 13 high high JJ cord-303447-3a7jxl34 72 14 safety safety NN cord-303447-3a7jxl34 72 15 standard standard NN cord-303447-3a7jxl34 72 16 ; ; : cord-303447-3a7jxl34 72 17 however however RB cord-303447-3a7jxl34 72 18 , , , cord-303447-3a7jxl34 72 19 no no DT cord-303447-3a7jxl34 72 20 vaccine vaccine NN cord-303447-3a7jxl34 72 21 is be VBZ cord-303447-3a7jxl34 72 22 completely completely RB cord-303447-3a7jxl34 72 23 safe safe JJ cord-303447-3a7jxl34 72 24 . . . cord-303447-3a7jxl34 73 1 In in IN cord-303447-3a7jxl34 73 2 1986 1986 CD cord-303447-3a7jxl34 73 3 , , , cord-303447-3a7jxl34 73 4 the the DT cord-303447-3a7jxl34 73 5 National National NNP cord-303447-3a7jxl34 73 6 Childhood Childhood NNP cord-303447-3a7jxl34 73 7 Vaccine Vaccine NNP cord-303447-3a7jxl34 73 8 Injury Injury NNP cord-303447-3a7jxl34 73 9 Act Act NNP cord-303447-3a7jxl34 73 10 was be VBD cord-303447-3a7jxl34 73 11 passed pass VBN cord-303447-3a7jxl34 73 12 creating create VBG cord-303447-3a7jxl34 73 13 a a DT cord-303447-3a7jxl34 73 14 compensation compensation NN cord-303447-3a7jxl34 73 15 program program NN cord-303447-3a7jxl34 73 16 for for IN cord-303447-3a7jxl34 73 17 families family NNS cord-303447-3a7jxl34 73 18 affected affect VBN cord-303447-3a7jxl34 73 19 by by IN cord-303447-3a7jxl34 73 20 childhood childhood NN cord-303447-3a7jxl34 73 21 vaccine vaccine NN cord-303447-3a7jxl34 73 22 - - HYPH cord-303447-3a7jxl34 73 23 associated associate VBN cord-303447-3a7jxl34 73 24 adverse adverse JJ cord-303447-3a7jxl34 73 25 events event NNS cord-303447-3a7jxl34 73 26 . . . cord-303447-3a7jxl34 74 1 Several several JJ cord-303447-3a7jxl34 74 2 other other JJ cord-303447-3a7jxl34 74 3 government government NN cord-303447-3a7jxl34 74 4 programs program NNS cord-303447-3a7jxl34 74 5 and and CC cord-303447-3a7jxl34 74 6 committees committee NNS cord-303447-3a7jxl34 74 7 to to TO cord-303447-3a7jxl34 74 8 ensure ensure VB cord-303447-3a7jxl34 74 9 the the DT cord-303447-3a7jxl34 74 10 safety safety NN cord-303447-3a7jxl34 74 11 of of IN cord-303447-3a7jxl34 74 12 the the DT cord-303447-3a7jxl34 74 13 vaccine vaccine NN cord-303447-3a7jxl34 74 14 supply supply NN cord-303447-3a7jxl34 74 15 also also RB cord-303447-3a7jxl34 74 16 were be VBD cord-303447-3a7jxl34 74 17 created create VBN cord-303447-3a7jxl34 74 18 by by IN cord-303447-3a7jxl34 74 19 this this DT cord-303447-3a7jxl34 74 20 Act Act NNP cord-303447-3a7jxl34 74 21 ( ( -LRB- cord-303447-3a7jxl34 74 22 Table Table NNP cord-303447-3a7jxl34 74 23 5 5 CD cord-303447-3a7jxl34 74 24 ) ) -RRB- cord-303447-3a7jxl34 74 25 . . . cord-303447-3a7jxl34 75 1 As as IN cord-303447-3a7jxl34 75 2 many many JJ cord-303447-3a7jxl34 75 3 vaccine vaccine NN cord-303447-3a7jxl34 75 4 - - HYPH cord-303447-3a7jxl34 75 5 preventable preventable JJ cord-303447-3a7jxl34 75 6 diseases disease NNS cord-303447-3a7jxl34 75 7 approach approach VBP cord-303447-3a7jxl34 75 8 or or CC cord-303447-3a7jxl34 75 9 reach reach VB cord-303447-3a7jxl34 75 10 elimination elimination NN cord-303447-3a7jxl34 75 11 in in IN cord-303447-3a7jxl34 75 12 the the DT cord-303447-3a7jxl34 75 13 United United NNP cord-303447-3a7jxl34 75 14 States States NNP cord-303447-3a7jxl34 75 15 , , , cord-303447-3a7jxl34 75 16 continuing continue VBG cord-303447-3a7jxl34 75 17 to to TO cord-303447-3a7jxl34 75 18 balance balance VB cord-303447-3a7jxl34 75 19 the the DT cord-303447-3a7jxl34 75 20 risks risk NNS cord-303447-3a7jxl34 75 21 and and CC cord-303447-3a7jxl34 75 22 benefits benefit NNS cord-303447-3a7jxl34 75 23 of of IN cord-303447-3a7jxl34 75 24 each each DT cord-303447-3a7jxl34 75 25 vaccine vaccine NN cord-303447-3a7jxl34 75 26 becomes become VBZ cord-303447-3a7jxl34 75 27 increasingly increasingly RB cord-303447-3a7jxl34 75 28 important important JJ cord-303447-3a7jxl34 75 29 [ [ -LRB- cord-303447-3a7jxl34 75 30 28 28 CD cord-303447-3a7jxl34 75 31 ] ] -RRB- cord-303447-3a7jxl34 75 32 . . . cord-303447-3a7jxl34 76 1 OPV OPV NNP cord-303447-3a7jxl34 76 2 , , , cord-303447-3a7jxl34 76 3 formerly formerly RB cord-303447-3a7jxl34 76 4 recommended recommend VBD cord-303447-3a7jxl34 76 5 for for IN cord-303447-3a7jxl34 76 6 routine routine JJ cord-303447-3a7jxl34 76 7 use use NN cord-303447-3a7jxl34 76 8 in in IN cord-303447-3a7jxl34 76 9 the the DT cord-303447-3a7jxl34 76 10 United United NNP cord-303447-3a7jxl34 76 11 States States NNP cord-303447-3a7jxl34 76 12 , , , cord-303447-3a7jxl34 76 13 was be VBD cord-303447-3a7jxl34 76 14 associated associate VBN cord-303447-3a7jxl34 76 15 with with IN cord-303447-3a7jxl34 76 16 vaccine vaccine NN cord-303447-3a7jxl34 76 17 - - HYPH cord-303447-3a7jxl34 76 18 associated associate VBN cord-303447-3a7jxl34 76 19 paralytic paralytic JJ cord-303447-3a7jxl34 76 20 poliomyelitis poliomyelitis NN cord-303447-3a7jxl34 76 21 ( ( -LRB- cord-303447-3a7jxl34 76 22 1 1 CD cord-303447-3a7jxl34 76 23 case case NN cord-303447-3a7jxl34 76 24 among among IN cord-303447-3a7jxl34 76 25 2.4 2.4 CD cord-303447-3a7jxl34 76 26 million million CD cord-303447-3a7jxl34 76 27 vaccine vaccine NN cord-303447-3a7jxl34 76 28 doses dose NNS cord-303447-3a7jxl34 76 29 distributed distribute VBN cord-303447-3a7jxl34 76 30 ) ) -RRB- cord-303447-3a7jxl34 76 31 . . . cord-303447-3a7jxl34 77 1 This this DT cord-303447-3a7jxl34 77 2 rare rare JJ cord-303447-3a7jxl34 77 3 adverse adverse JJ cord-303447-3a7jxl34 77 4 event event NN cord-303447-3a7jxl34 77 5 was be VBD cord-303447-3a7jxl34 77 6 no no RB cord-303447-3a7jxl34 77 7 longer long RBR cord-303447-3a7jxl34 77 8 considered consider VBN cord-303447-3a7jxl34 77 9 acceptable acceptable JJ cord-303447-3a7jxl34 77 10 after after IN cord-303447-3a7jxl34 77 11 elimination elimination NN cord-303447-3a7jxl34 77 12 of of IN cord-303447-3a7jxl34 77 13 polio polio NN cord-303447-3a7jxl34 77 14 in in IN cord-303447-3a7jxl34 77 15 the the DT cord-303447-3a7jxl34 77 16 United United NNP cord-303447-3a7jxl34 77 17 States States NNP cord-303447-3a7jxl34 77 18 [ [ -LRB- cord-303447-3a7jxl34 77 19 29 29 CD cord-303447-3a7jxl34 77 20 ] ] -RRB- cord-303447-3a7jxl34 77 21 . . . cord-303447-3a7jxl34 78 1 In in IN cord-303447-3a7jxl34 78 2 2000 2000 CD cord-303447-3a7jxl34 78 3 , , , cord-303447-3a7jxl34 78 4 the the DT cord-303447-3a7jxl34 78 5 ACIP ACIP NNP cord-303447-3a7jxl34 78 6 recommended recommend VBD cord-303447-3a7jxl34 78 7 using use VBG cord-303447-3a7jxl34 78 8 IPV IPV NNP cord-303447-3a7jxl34 78 9 for for IN cord-303447-3a7jxl34 78 10 all all DT cord-303447-3a7jxl34 78 11 doses dose NNS cord-303447-3a7jxl34 78 12 of of IN cord-303447-3a7jxl34 78 13 polio polio NN cord-303447-3a7jxl34 78 14 vaccine vaccine NN cord-303447-3a7jxl34 78 15 . . . cord-303447-3a7jxl34 79 1 Public public JJ cord-303447-3a7jxl34 79 2 perceptions perception NNS cord-303447-3a7jxl34 79 3 of of IN cord-303447-3a7jxl34 79 4 vaccine vaccine NN cord-303447-3a7jxl34 79 5 safety safety NN cord-303447-3a7jxl34 79 6 are be VBP cord-303447-3a7jxl34 79 7 a a DT cord-303447-3a7jxl34 79 8 challenge challenge NN cord-303447-3a7jxl34 79 9 to to IN cord-303447-3a7jxl34 79 10 the the DT cord-303447-3a7jxl34 79 11 continued continue VBN cord-303447-3a7jxl34 79 12 success success NN cord-303447-3a7jxl34 79 13 of of IN cord-303447-3a7jxl34 79 14 the the DT cord-303447-3a7jxl34 79 15 vaccination vaccination NN cord-303447-3a7jxl34 79 16 program program NN cord-303447-3a7jxl34 79 17 . . . cord-303447-3a7jxl34 80 1 New new JJ cord-303447-3a7jxl34 80 2 parents parent NNS cord-303447-3a7jxl34 80 3 and and CC cord-303447-3a7jxl34 80 4 younger young JJR cord-303447-3a7jxl34 80 5 physicians physician NNS cord-303447-3a7jxl34 80 6 grew grow VBD cord-303447-3a7jxl34 80 7 up up RP cord-303447-3a7jxl34 80 8 without without IN cord-303447-3a7jxl34 80 9 appreciation appreciation NN cord-303447-3a7jxl34 80 10 of of IN cord-303447-3a7jxl34 80 11 the the DT cord-303447-3a7jxl34 80 12 morbidity morbidity NN cord-303447-3a7jxl34 80 13 and and CC cord-303447-3a7jxl34 80 14 mortality mortality NN cord-303447-3a7jxl34 80 15 of of IN cord-303447-3a7jxl34 80 16 immunizations immunization NNS cord-303447-3a7jxl34 80 17 in in IN cord-303447-3a7jxl34 80 18 the the DT cord-303447-3a7jxl34 80 19 us us NNP cord-303447-3a7jxl34 80 20 several several JJ cord-303447-3a7jxl34 80 21 vaccine vaccine NN cord-303447-3a7jxl34 80 22 - - HYPH cord-303447-3a7jxl34 80 23 preventable preventable JJ cord-303447-3a7jxl34 80 24 diseases disease NNS cord-303447-3a7jxl34 80 25 . . . cord-303447-3a7jxl34 81 1 Risk risk NN cord-303447-3a7jxl34 81 2 or or CC cord-303447-3a7jxl34 81 3 perception perception NN cord-303447-3a7jxl34 81 4 of of IN cord-303447-3a7jxl34 81 5 risk risk NN cord-303447-3a7jxl34 81 6 for for IN cord-303447-3a7jxl34 81 7 adverse adverse JJ cord-303447-3a7jxl34 81 8 events event NNS cord-303447-3a7jxl34 81 9 becomes become VBZ cord-303447-3a7jxl34 81 10 an an DT cord-303447-3a7jxl34 81 11 important important JJ cord-303447-3a7jxl34 81 12 concern concern NN cord-303447-3a7jxl34 81 13 . . . cord-303447-3a7jxl34 82 1 Two two CD cord-303447-3a7jxl34 82 2 current current JJ cord-303447-3a7jxl34 82 3 prominent prominent JJ cord-303447-3a7jxl34 82 4 public public JJ cord-303447-3a7jxl34 82 5 vaccine vaccine NN cord-303447-3a7jxl34 82 6 safety safety NN cord-303447-3a7jxl34 82 7 concerns concern NNS cord-303447-3a7jxl34 82 8 are be VBP cord-303447-3a7jxl34 82 9 the the DT cord-303447-3a7jxl34 82 10 perceived perceive VBN cord-303447-3a7jxl34 82 11 causal causal JJ cord-303447-3a7jxl34 82 12 association association NN cord-303447-3a7jxl34 82 13 between between IN cord-303447-3a7jxl34 82 14 MMR MMR NNP cord-303447-3a7jxl34 82 15 and and CC cord-303447-3a7jxl34 82 16 autism autism NN cord-303447-3a7jxl34 82 17 and and CC cord-303447-3a7jxl34 82 18 thimerosal thimerosal NN cord-303447-3a7jxl34 82 19 - - HYPH cord-303447-3a7jxl34 82 20 containing contain VBG cord-303447-3a7jxl34 82 21 vaccines vaccine NNS cord-303447-3a7jxl34 82 22 and and CC cord-303447-3a7jxl34 82 23 autism autism NN cord-303447-3a7jxl34 82 24 . . . cord-303447-3a7jxl34 83 1 As as IN cord-303447-3a7jxl34 83 2 a a DT cord-303447-3a7jxl34 83 3 result result NN cord-303447-3a7jxl34 83 4 of of IN cord-303447-3a7jxl34 83 5 heightened heightened JJ cord-303447-3a7jxl34 83 6 concerns concern NNS cord-303447-3a7jxl34 83 7 about about IN cord-303447-3a7jxl34 83 8 safety safety NN cord-303447-3a7jxl34 83 9 , , , cord-303447-3a7jxl34 83 10 in in IN cord-303447-3a7jxl34 83 11 2000 2000 CD cord-303447-3a7jxl34 83 12 the the DT cord-303447-3a7jxl34 83 13 CDC CDC NNP cord-303447-3a7jxl34 83 14 and and CC cord-303447-3a7jxl34 83 15 National National NNP cord-303447-3a7jxl34 83 16 Institutes Institutes NNPS cord-303447-3a7jxl34 83 17 of of IN cord-303447-3a7jxl34 83 18 Health Health NNP cord-303447-3a7jxl34 83 19 commissioned commission VBD cord-303447-3a7jxl34 83 20 the the DT cord-303447-3a7jxl34 83 21 IOM IOM NNP cord-303447-3a7jxl34 83 22 of of IN cord-303447-3a7jxl34 83 23 the the DT cord-303447-3a7jxl34 83 24 National National NNP cord-303447-3a7jxl34 83 25 Academy Academy NNP cord-303447-3a7jxl34 83 26 of of IN cord-303447-3a7jxl34 83 27 Science Science NNP cord-303447-3a7jxl34 83 28 to to TO cord-303447-3a7jxl34 83 29 convene convene VB cord-303447-3a7jxl34 83 30 an an DT cord-303447-3a7jxl34 83 31 Immunization Immunization NNP cord-303447-3a7jxl34 83 32 Safety Safety NNP cord-303447-3a7jxl34 83 33 Review Review NNP cord-303447-3a7jxl34 83 34 Committee Committee NNP cord-303447-3a7jxl34 83 35 [ [ -LRB- cord-303447-3a7jxl34 83 36 30 30 CD cord-303447-3a7jxl34 83 37 ] ] -RRB- cord-303447-3a7jxl34 83 38 . . . cord-303447-3a7jxl34 84 1 Between between IN cord-303447-3a7jxl34 84 2 2001 2001 CD cord-303447-3a7jxl34 84 3 and and CC cord-303447-3a7jxl34 84 4 2004 2004 CD cord-303447-3a7jxl34 84 5 , , , cord-303447-3a7jxl34 84 6 this this DT cord-303447-3a7jxl34 84 7 independent independent JJ cord-303447-3a7jxl34 84 8 expert expert NN cord-303447-3a7jxl34 84 9 committee committee NN cord-303447-3a7jxl34 84 10 published publish VBD cord-303447-3a7jxl34 84 11 eight eight CD cord-303447-3a7jxl34 84 12 reports report NNS cord-303447-3a7jxl34 84 13 related relate VBN cord-303447-3a7jxl34 84 14 to to IN cord-303447-3a7jxl34 84 15 immunization immunization NN cord-303447-3a7jxl34 84 16 safety safety NN cord-303447-3a7jxl34 84 17 concerns concern NNS cord-303447-3a7jxl34 84 18 . . . cord-303447-3a7jxl34 85 1 The the DT cord-303447-3a7jxl34 85 2 committee committee NN cord-303447-3a7jxl34 85 3 has have VBZ cord-303447-3a7jxl34 85 4 made make VBN cord-303447-3a7jxl34 85 5 recommendations recommendation NNS cord-303447-3a7jxl34 85 6 in in IN cord-303447-3a7jxl34 85 7 the the DT cord-303447-3a7jxl34 85 8 areas area NNS cord-303447-3a7jxl34 85 9 of of IN cord-303447-3a7jxl34 85 10 public public JJ cord-303447-3a7jxl34 85 11 health health NN cord-303447-3a7jxl34 85 12 response response NN cord-303447-3a7jxl34 85 13 , , , cord-303447-3a7jxl34 85 14 policy policy NN cord-303447-3a7jxl34 85 15 review review NN cord-303447-3a7jxl34 85 16 , , , cord-303447-3a7jxl34 85 17 research research NN cord-303447-3a7jxl34 85 18 , , , cord-303447-3a7jxl34 85 19 and and CC cord-303447-3a7jxl34 85 20 communications communication NNS cord-303447-3a7jxl34 85 21 ( ( -LRB- cord-303447-3a7jxl34 85 22 Box Box NNP cord-303447-3a7jxl34 85 23 1 1 CD cord-303447-3a7jxl34 85 24 ) ) -RRB- cord-303447-3a7jxl34 85 25 . . . cord-303447-3a7jxl34 86 1 With with IN cord-303447-3a7jxl34 86 2 respect respect NN cord-303447-3a7jxl34 86 3 to to IN cord-303447-3a7jxl34 86 4 autism autism NN cord-303447-3a7jxl34 86 5 , , , cord-303447-3a7jxl34 86 6 the the DT cord-303447-3a7jxl34 86 7 IOM IOM NNP cord-303447-3a7jxl34 86 8 concluded conclude VBD cord-303447-3a7jxl34 86 9 that that IN cord-303447-3a7jxl34 86 10 the the DT cord-303447-3a7jxl34 86 11 body body NN cord-303447-3a7jxl34 86 12 of of IN cord-303447-3a7jxl34 86 13 epidemiologic epidemiologic JJ cord-303447-3a7jxl34 86 14 evidence evidence NN cord-303447-3a7jxl34 86 15 favors favor VBZ cord-303447-3a7jxl34 86 16 rejection rejection NN cord-303447-3a7jxl34 86 17 of of IN cord-303447-3a7jxl34 86 18 a a DT cord-303447-3a7jxl34 86 19 causal causal JJ cord-303447-3a7jxl34 86 20 relationship relationship NN cord-303447-3a7jxl34 86 21 between between IN cord-303447-3a7jxl34 86 22 the the DT cord-303447-3a7jxl34 86 23 MMR MMR NNP cord-303447-3a7jxl34 86 24 vaccine vaccine NN cord-303447-3a7jxl34 86 25 and and CC cord-303447-3a7jxl34 86 26 autism autism NN cord-303447-3a7jxl34 86 27 . . . cord-303447-3a7jxl34 87 1 The the DT cord-303447-3a7jxl34 87 2 committee committee NN cord-303447-3a7jxl34 87 3 also also RB cord-303447-3a7jxl34 87 4 concluded conclude VBD cord-303447-3a7jxl34 87 5 that that IN cord-303447-3a7jxl34 87 6 there there EX cord-303447-3a7jxl34 87 7 is be VBZ cord-303447-3a7jxl34 87 8 no no DT cord-303447-3a7jxl34 87 9 relationship relationship NN cord-303447-3a7jxl34 87 10 between between IN cord-303447-3a7jxl34 87 11 thimerosal thimerosal NN cord-303447-3a7jxl34 87 12 - - HYPH cord-303447-3a7jxl34 87 13 containing contain VBG cord-303447-3a7jxl34 87 14 vaccines vaccine NNS cord-303447-3a7jxl34 87 15 and and CC cord-303447-3a7jxl34 87 16 autism autism NN cord-303447-3a7jxl34 87 17 [ [ -LRB- cord-303447-3a7jxl34 87 18 30 30 CD cord-303447-3a7jxl34 87 19 ] ] -RRB- cord-303447-3a7jxl34 87 20 . . . cord-303447-3a7jxl34 88 1 None none NN cord-303447-3a7jxl34 88 2 of of IN cord-303447-3a7jxl34 88 3 the the DT cord-303447-3a7jxl34 88 4 eight eight CD cord-303447-3a7jxl34 88 5 IOM IOM NNP cord-303447-3a7jxl34 88 6 reports report NNS cord-303447-3a7jxl34 88 7 recommended recommend VBD cord-303447-3a7jxl34 88 8 a a DT cord-303447-3a7jxl34 88 9 policy policy NN cord-303447-3a7jxl34 88 10 review review NN cord-303447-3a7jxl34 88 11 of of IN cord-303447-3a7jxl34 88 12 the the DT cord-303447-3a7jxl34 88 13 current current JJ cord-303447-3a7jxl34 88 14 vaccine vaccine NN cord-303447-3a7jxl34 88 15 recommendations recommendation NNS cord-303447-3a7jxl34 88 16 or or CC cord-303447-3a7jxl34 88 17 change change NN cord-303447-3a7jxl34 88 18 in in IN cord-303447-3a7jxl34 88 19 the the DT cord-303447-3a7jxl34 88 20 immunization immunization NN cord-303447-3a7jxl34 88 21 schedule schedule NN cord-303447-3a7jxl34 88 22 . . . cord-303447-3a7jxl34 89 1 To to TO cord-303447-3a7jxl34 89 2 help help VB cord-303447-3a7jxl34 89 3 ensure ensure VB cord-303447-3a7jxl34 89 4 safety safety NN cord-303447-3a7jxl34 89 5 of of IN cord-303447-3a7jxl34 89 6 vaccines vaccine NNS cord-303447-3a7jxl34 89 7 , , , cord-303447-3a7jxl34 89 8 a a DT cord-303447-3a7jxl34 89 9 robust robust JJ cord-303447-3a7jxl34 89 10 infrastructure infrastructure NN cord-303447-3a7jxl34 89 11 consisting consisting NN cord-303447-3a7jxl34 89 12 of of IN cord-303447-3a7jxl34 89 13 several several JJ cord-303447-3a7jxl34 89 14 systems system NNS cord-303447-3a7jxl34 89 15 has have VBZ cord-303447-3a7jxl34 89 16 been be VBN cord-303447-3a7jxl34 89 17 established establish VBN cord-303447-3a7jxl34 89 18 to to TO cord-303447-3a7jxl34 89 19 monitor monitor VB cord-303447-3a7jxl34 89 20 vaccine vaccine NN cord-303447-3a7jxl34 89 21 safety safety NN cord-303447-3a7jxl34 89 22 after after IN cord-303447-3a7jxl34 89 23 vaccine vaccine NN cord-303447-3a7jxl34 89 24 licensure licensure NN cord-303447-3a7jxl34 89 25 . . . cord-303447-3a7jxl34 90 1 The the DT cord-303447-3a7jxl34 90 2 Vaccine Vaccine NNP cord-303447-3a7jxl34 90 3 Adverse adverse JJ cord-303447-3a7jxl34 90 4 Event Event NNP cord-303447-3a7jxl34 90 5 Reporting Reporting NNP cord-303447-3a7jxl34 90 6 System System NNP cord-303447-3a7jxl34 90 7 , , , cord-303447-3a7jxl34 90 8 operated operate VBD cord-303447-3a7jxl34 90 9 jointly jointly RB cord-303447-3a7jxl34 90 10 by by IN cord-303447-3a7jxl34 90 11 CDC CDC NNP cord-303447-3a7jxl34 90 12 and and CC cord-303447-3a7jxl34 90 13 FDA FDA NNP cord-303447-3a7jxl34 90 14 , , , cord-303447-3a7jxl34 90 15 is be VBZ cord-303447-3a7jxl34 90 16 a a DT cord-303447-3a7jxl34 90 17 national national JJ cord-303447-3a7jxl34 90 18 passive passive JJ cord-303447-3a7jxl34 90 19 surveillance surveillance NN cord-303447-3a7jxl34 90 20 system system NN cord-303447-3a7jxl34 90 21 used use VBN cord-303447-3a7jxl34 90 22 to to TO cord-303447-3a7jxl34 90 23 detect detect VB cord-303447-3a7jxl34 90 24 early early JJ cord-303447-3a7jxl34 90 25 warning warning NN cord-303447-3a7jxl34 90 26 signals signal NNS cord-303447-3a7jxl34 90 27 and and CC cord-303447-3a7jxl34 90 28 generate generate VB cord-303447-3a7jxl34 90 29 hypotheses hypothesis NNS cord-303447-3a7jxl34 90 30 about about IN cord-303447-3a7jxl34 90 31 possible possible JJ cord-303447-3a7jxl34 90 32 new new JJ cord-303447-3a7jxl34 90 33 vaccine vaccine NN cord-303447-3a7jxl34 90 34 adverse adverse JJ cord-303447-3a7jxl34 90 35 events event NNS cord-303447-3a7jxl34 90 36 or or CC cord-303447-3a7jxl34 90 37 changes change NNS cord-303447-3a7jxl34 90 38 in in IN cord-303447-3a7jxl34 90 39 frequency frequency NN cord-303447-3a7jxl34 90 40 of of IN cord-303447-3a7jxl34 90 41 recognized recognize VBN cord-303447-3a7jxl34 90 42 events event NNS cord-303447-3a7jxl34 90 43 [ [ -LRB- cord-303447-3a7jxl34 90 44 31 31 CD cord-303447-3a7jxl34 90 45 ] ] -RRB- cord-303447-3a7jxl34 90 46 . . . cord-303447-3a7jxl34 91 1 Intussusception intussusception NN cord-303447-3a7jxl34 91 2 associated associate VBN cord-303447-3a7jxl34 91 3 with with IN cord-303447-3a7jxl34 91 4 receipt receipt NN cord-303447-3a7jxl34 91 5 of of IN cord-303447-3a7jxl34 91 6 rotavirus rotavirus JJ cord-303447-3a7jxl34 91 7 vaccine vaccine NN cord-303447-3a7jxl34 91 8 , , , cord-303447-3a7jxl34 91 9 leading lead VBG cord-303447-3a7jxl34 91 10 to to IN cord-303447-3a7jxl34 91 11 the the DT cord-303447-3a7jxl34 91 12 withdrawal withdrawal NN cord-303447-3a7jxl34 91 13 of of IN cord-303447-3a7jxl34 91 14 the the DT cord-303447-3a7jxl34 91 15 vaccine vaccine NN cord-303447-3a7jxl34 91 16 from from IN cord-303447-3a7jxl34 91 17 the the DT cord-303447-3a7jxl34 91 18 market market NN cord-303447-3a7jxl34 91 19 in in IN cord-303447-3a7jxl34 91 20 1999 1999 CD cord-303447-3a7jxl34 91 21 , , , cord-303447-3a7jxl34 91 22 was be VBD cord-303447-3a7jxl34 91 23 an an DT cord-303447-3a7jxl34 91 24 adverse adverse JJ cord-303447-3a7jxl34 91 25 event event NN cord-303447-3a7jxl34 91 26 detected detect VBN cord-303447-3a7jxl34 91 27 by by IN cord-303447-3a7jxl34 91 28 the the DT cord-303447-3a7jxl34 91 29 Vaccine Vaccine NNP cord-303447-3a7jxl34 91 30 Adverse Adverse NNP cord-303447-3a7jxl34 91 31 Event Event NNP cord-303447-3a7jxl34 91 32 Reporting Reporting NNP cord-303447-3a7jxl34 91 33 System System NNP cord-303447-3a7jxl34 91 34 [ [ -LRB- cord-303447-3a7jxl34 91 35 31 31 CD cord-303447-3a7jxl34 91 36 , , , cord-303447-3a7jxl34 91 37 32 32 CD cord-303447-3a7jxl34 91 38 ] ] -RRB- cord-303447-3a7jxl34 91 39 . . . cord-303447-3a7jxl34 92 1 A a DT cord-303447-3a7jxl34 92 2 third third JJ cord-303447-3a7jxl34 92 3 system system NN cord-303447-3a7jxl34 92 4 is be VBZ cord-303447-3a7jxl34 92 5 the the DT cord-303447-3a7jxl34 92 6 Vaccine Vaccine NNP cord-303447-3a7jxl34 92 7 Safety Safety NNP cord-303447-3a7jxl34 92 8 Datalink Datalink NNP cord-303447-3a7jxl34 92 9 , , , cord-303447-3a7jxl34 92 10 which which WDT cord-303447-3a7jxl34 92 11 consists consist VBZ cord-303447-3a7jxl34 92 12 of of IN cord-303447-3a7jxl34 92 13 large large JJ cord-303447-3a7jxl34 92 14 linked link VBN cord-303447-3a7jxl34 92 15 databases database NNS cord-303447-3a7jxl34 92 16 from from IN cord-303447-3a7jxl34 92 17 health health NN cord-303447-3a7jxl34 92 18 maintenance maintenance NN cord-303447-3a7jxl34 92 19 organizations organization NNS cord-303447-3a7jxl34 92 20 . . . cord-303447-3a7jxl34 93 1 Associations association NNS cord-303447-3a7jxl34 93 2 between between IN cord-303447-3a7jxl34 93 3 serious serious JJ cord-303447-3a7jxl34 93 4 medical medical JJ cord-303447-3a7jxl34 93 5 events event NNS cord-303447-3a7jxl34 93 6 and and CC cord-303447-3a7jxl34 93 7 immunizations immunization NNS cord-303447-3a7jxl34 93 8 can can MD cord-303447-3a7jxl34 93 9 be be VB cord-303447-3a7jxl34 93 10 evaluated evaluate VBN cord-303447-3a7jxl34 93 11 through through IN cord-303447-3a7jxl34 93 12 the the DT cord-303447-3a7jxl34 93 13 Vaccine Vaccine NNP cord-303447-3a7jxl34 93 14 Safety Safety NNP cord-303447-3a7jxl34 93 15 Datalink Datalink NNP cord-303447-3a7jxl34 93 16 . . . cord-303447-3a7jxl34 94 1 The the DT cord-303447-3a7jxl34 94 2 newest new JJS cord-303447-3a7jxl34 94 3 system system NN cord-303447-3a7jxl34 94 4 is be VBZ cord-303447-3a7jxl34 94 5 the the DT cord-303447-3a7jxl34 94 6 Clinical Clinical NNP cord-303447-3a7jxl34 94 7 Immunization Immunization NNP cord-303447-3a7jxl34 94 8 Safety Safety NNP cord-303447-3a7jxl34 94 9 Assessment Assessment NNP cord-303447-3a7jxl34 94 10 Centers Centers NNPS cord-303447-3a7jxl34 94 11 network network NN cord-303447-3a7jxl34 94 12 , , , cord-303447-3a7jxl34 94 13 which which WDT cord-303447-3a7jxl34 94 14 consists consist VBZ cord-303447-3a7jxl34 94 15 of of IN cord-303447-3a7jxl34 94 16 selected select VBN cord-303447-3a7jxl34 94 17 clinical clinical JJ cord-303447-3a7jxl34 94 18 academic academic JJ cord-303447-3a7jxl34 94 19 medical medical JJ cord-303447-3a7jxl34 94 20 centers center NNS cord-303447-3a7jxl34 94 21 in in IN cord-303447-3a7jxl34 94 22 partnership partnership NN cord-303447-3a7jxl34 94 23 with with IN cord-303447-3a7jxl34 94 24 CDC CDC NNP cord-303447-3a7jxl34 94 25 to to TO cord-303447-3a7jxl34 94 26 study study VB cord-303447-3a7jxl34 94 27 the the DT cord-303447-3a7jxl34 94 28 pathophysiology pathophysiology NN cord-303447-3a7jxl34 94 29 of of IN cord-303447-3a7jxl34 94 30 vaccine vaccine NN cord-303447-3a7jxl34 94 31 reactions reaction NNS cord-303447-3a7jxl34 94 32 and and CC cord-303447-3a7jxl34 94 33 develop develop VB cord-303447-3a7jxl34 94 34 clinical clinical JJ cord-303447-3a7jxl34 94 35 management management NN cord-303447-3a7jxl34 94 36 protocols protocol NNS cord-303447-3a7jxl34 94 37 for for IN cord-303447-3a7jxl34 94 38 affected affected JJ cord-303447-3a7jxl34 94 39 patients patient NNS cord-303447-3a7jxl34 94 40 [ [ -LRB- cord-303447-3a7jxl34 94 41 34 34 CD cord-303447-3a7jxl34 94 42 ] ] -RRB- cord-303447-3a7jxl34 94 43 . . . cord-303447-3a7jxl34 95 1 These these DT cord-303447-3a7jxl34 95 2 systems system NNS cord-303447-3a7jxl34 95 3 are be VBP cord-303447-3a7jxl34 95 4 crucial crucial JJ cord-303447-3a7jxl34 95 5 to to IN cord-303447-3a7jxl34 95 6 the the DT cord-303447-3a7jxl34 95 7 vitality vitality NN cord-303447-3a7jxl34 95 8 and and CC cord-303447-3a7jxl34 95 9 strength strength NN cord-303447-3a7jxl34 95 10 of of IN cord-303447-3a7jxl34 95 11 the the DT cord-303447-3a7jxl34 95 12 US US NNP cord-303447-3a7jxl34 95 13 immunization immunization NN cord-303447-3a7jxl34 95 14 program program NN cord-303447-3a7jxl34 95 15 . . . cord-303447-3a7jxl34 96 1 Since since IN cord-303447-3a7jxl34 96 2 its -PRON- PRP$ cord-303447-3a7jxl34 96 3 inception inception NN cord-303447-3a7jxl34 96 4 , , , cord-303447-3a7jxl34 96 5 the the DT cord-303447-3a7jxl34 96 6 major major JJ cord-303447-3a7jxl34 96 7 focus focus NN cord-303447-3a7jxl34 96 8 of of IN cord-303447-3a7jxl34 96 9 the the DT cord-303447-3a7jxl34 96 10 US US NNP cord-303447-3a7jxl34 96 11 immunization immunization NN cord-303447-3a7jxl34 96 12 program program NN cord-303447-3a7jxl34 96 13 has have VBZ cord-303447-3a7jxl34 96 14 been be VBN cord-303447-3a7jxl34 96 15 on on IN cord-303447-3a7jxl34 96 16 vaccinating vaccinate VBG cord-303447-3a7jxl34 96 17 infants infant NNS cord-303447-3a7jxl34 96 18 and and CC cord-303447-3a7jxl34 96 19 young young JJ cord-303447-3a7jxl34 96 20 children child NNS cord-303447-3a7jxl34 96 21 . . . cord-303447-3a7jxl34 97 1 Of of IN cord-303447-3a7jxl34 97 2 the the DT cord-303447-3a7jxl34 97 3 10 10 CD cord-303447-3a7jxl34 97 4 vaccines vaccine NNS cord-303447-3a7jxl34 97 5 routinely routinely RB cord-303447-3a7jxl34 97 6 recommended recommend VBN cord-303447-3a7jxl34 97 7 for for IN cord-303447-3a7jxl34 97 8 children child NNS cord-303447-3a7jxl34 97 9 and and CC cord-303447-3a7jxl34 97 10 adolescents adolescent NNS cord-303447-3a7jxl34 97 11 , , , cord-303447-3a7jxl34 97 12 only only RB cord-303447-3a7jxl34 97 13 two two CD cord-303447-3a7jxl34 97 14 , , , cord-303447-3a7jxl34 97 15 Td Td NNP cord-303447-3a7jxl34 97 16 vaccine vaccine NN cord-303447-3a7jxl34 97 17 and and CC cord-303447-3a7jxl34 97 18 the the DT cord-303447-3a7jxl34 97 19 MCV4 MCV4 NNP cord-303447-3a7jxl34 97 20 , , , cord-303447-3a7jxl34 97 21 are be VBP cord-303447-3a7jxl34 97 22 recommended recommend VBN cord-303447-3a7jxl34 97 23 for for IN cord-303447-3a7jxl34 97 24 all all DT cord-303447-3a7jxl34 97 25 adolescents adolescent NNS cord-303447-3a7jxl34 97 26 [ [ -LRB- cord-303447-3a7jxl34 97 27 8 8 CD cord-303447-3a7jxl34 97 28 ] ] -RRB- cord-303447-3a7jxl34 97 29 . . . cord-303447-3a7jxl34 98 1 In in IN cord-303447-3a7jxl34 98 2 1996 1996 CD cord-303447-3a7jxl34 98 3 , , , cord-303447-3a7jxl34 98 4 as as IN cord-303447-3a7jxl34 98 5 a a DT cord-303447-3a7jxl34 98 6 result result NN cord-303447-3a7jxl34 98 7 of of IN cord-303447-3a7jxl34 98 8 growing grow VBG cord-303447-3a7jxl34 98 9 concern concern NN cord-303447-3a7jxl34 98 10 about about IN cord-303447-3a7jxl34 98 11 morbidity morbidity NN cord-303447-3a7jxl34 98 12 associated associate VBN cord-303447-3a7jxl34 98 13 with with IN cord-303447-3a7jxl34 98 14 vaccine vaccine NN cord-303447-3a7jxl34 98 15 - - HYPH cord-303447-3a7jxl34 98 16 preventable preventable JJ cord-303447-3a7jxl34 98 17 diseases disease NNS cord-303447-3a7jxl34 98 18 in in IN cord-303447-3a7jxl34 98 19 the the DT cord-303447-3a7jxl34 98 20 hard hard JJ cord-303447-3a7jxl34 98 21 - - HYPH cord-303447-3a7jxl34 98 22 to to TO cord-303447-3a7jxl34 98 23 - - HYPH cord-303447-3a7jxl34 98 24 reach reach VB cord-303447-3a7jxl34 98 25 adolescent adolescent JJ cord-303447-3a7jxl34 98 26 population population NN cord-303447-3a7jxl34 98 27 , , , cord-303447-3a7jxl34 98 28 the the DT cord-303447-3a7jxl34 98 29 ACIP ACIP NNP cord-303447-3a7jxl34 98 30 recommended recommend VBD cord-303447-3a7jxl34 98 31 expanding expand VBG cord-303447-3a7jxl34 98 32 efforts effort NNS cord-303447-3a7jxl34 98 33 to to TO cord-303447-3a7jxl34 98 34 immunize immunize VB cord-303447-3a7jxl34 98 35 adolescents adolescent NNS cord-303447-3a7jxl34 98 36 ( ( -LRB- cord-303447-3a7jxl34 98 37 11 11 CD cord-303447-3a7jxl34 98 38 - - SYM cord-303447-3a7jxl34 98 39 21 21 CD cord-303447-3a7jxl34 98 40 years year NNS cord-303447-3a7jxl34 98 41 old old JJ cord-303447-3a7jxl34 98 42 ) ) -RRB- cord-303447-3a7jxl34 98 43 by by IN cord-303447-3a7jxl34 98 44 establishing establish VBG cord-303447-3a7jxl34 98 45 a a DT cord-303447-3a7jxl34 98 46 routine routine JJ cord-303447-3a7jxl34 98 47 vaccination vaccination NN cord-303447-3a7jxl34 98 48 visit visit NN cord-303447-3a7jxl34 98 49 at at IN cord-303447-3a7jxl34 98 50 11 11 CD cord-303447-3a7jxl34 98 51 to to TO cord-303447-3a7jxl34 98 52 12 12 CD cord-303447-3a7jxl34 98 53 years year NNS cord-303447-3a7jxl34 98 54 old old JJ cord-303447-3a7jxl34 98 55 [ [ -LRB- cord-303447-3a7jxl34 98 56 35 35 CD cord-303447-3a7jxl34 98 57 ] ] -RRB- cord-303447-3a7jxl34 98 58 . . . cord-303447-3a7jxl34 99 1 In in IN cord-303447-3a7jxl34 99 2 addition addition NN cord-303447-3a7jxl34 99 3 to to IN cord-303447-3a7jxl34 99 4 providing provide VBG cord-303447-3a7jxl34 99 5 Td Td NNP cord-303447-3a7jxl34 99 6 and and CC cord-303447-3a7jxl34 99 7 previously previously RB cord-303447-3a7jxl34 99 8 missed miss VBN cord-303447-3a7jxl34 99 9 vaccinations vaccination NNS cord-303447-3a7jxl34 99 10 , , , cord-303447-3a7jxl34 99 11 the the DT cord-303447-3a7jxl34 99 12 report report NN cord-303447-3a7jxl34 99 13 emphasized emphasize VBD cord-303447-3a7jxl34 99 14 that that IN cord-303447-3a7jxl34 99 15 this this DT cord-303447-3a7jxl34 99 16 visit visit NN cord-303447-3a7jxl34 99 17 should should MD cord-303447-3a7jxl34 99 18 be be VB cord-303447-3a7jxl34 99 19 used use VBN cord-303447-3a7jxl34 99 20 to to TO cord-303447-3a7jxl34 99 21 provide provide VB cord-303447-3a7jxl34 99 22 other other JJ cord-303447-3a7jxl34 99 23 important important JJ cord-303447-3a7jxl34 99 24 preventive preventive JJ cord-303447-3a7jxl34 99 25 health health NN cord-303447-3a7jxl34 99 26 services service NNS cord-303447-3a7jxl34 99 27 . . . cord-303447-3a7jxl34 100 1 The the DT cord-303447-3a7jxl34 100 2 anticipated anticipated JJ cord-303447-3a7jxl34 100 3 addition addition NN cord-303447-3a7jxl34 100 4 of of IN cord-303447-3a7jxl34 100 5 several several JJ cord-303447-3a7jxl34 100 6 new new JJ cord-303447-3a7jxl34 100 7 adolescent adolescent JJ cord-303447-3a7jxl34 100 8 vaccines vaccine NNS cord-303447-3a7jxl34 100 9 to to IN cord-303447-3a7jxl34 100 10 the the DT cord-303447-3a7jxl34 100 11 recommended recommend VBN cord-303447-3a7jxl34 100 12 schedule schedule NN cord-303447-3a7jxl34 100 13 has have VBZ cord-303447-3a7jxl34 100 14 stimulated stimulate VBN cord-303447-3a7jxl34 100 15 a a DT cord-303447-3a7jxl34 100 16 reappraisal reappraisal NN cord-303447-3a7jxl34 100 17 of of IN cord-303447-3a7jxl34 100 18 the the DT cord-303447-3a7jxl34 100 19 approaches approach NNS cord-303447-3a7jxl34 100 20 that that WDT cord-303447-3a7jxl34 100 21 most most RBS cord-303447-3a7jxl34 100 22 effectively effectively RB cord-303447-3a7jxl34 100 23 and and CC cord-303447-3a7jxl34 100 24 efficiently efficiently RB cord-303447-3a7jxl34 100 25 would would MD cord-303447-3a7jxl34 100 26 increase increase VB cord-303447-3a7jxl34 100 27 the the DT cord-303447-3a7jxl34 100 28 proportion proportion NN cord-303447-3a7jxl34 100 29 of of IN cord-303447-3a7jxl34 100 30 adolescents adolescent NNS cord-303447-3a7jxl34 100 31 who who WP cord-303447-3a7jxl34 100 32 receive receive VBP cord-303447-3a7jxl34 100 33 newly newly RB cord-303447-3a7jxl34 100 34 recommended recommend VBN cord-303447-3a7jxl34 100 35 vaccines vaccine NNS cord-303447-3a7jxl34 100 36 and and CC cord-303447-3a7jxl34 100 37 develop develop VB cord-303447-3a7jxl34 100 38 ways way NNS cord-303447-3a7jxl34 100 39 to to TO cord-303447-3a7jxl34 100 40 integrate integrate VB cord-303447-3a7jxl34 100 41 these these DT cord-303447-3a7jxl34 100 42 approaches approach NNS cord-303447-3a7jxl34 100 43 with with IN cord-303447-3a7jxl34 100 44 other other JJ cord-303447-3a7jxl34 100 45 adolescent adolescent JJ cord-303447-3a7jxl34 100 46 health health NN cord-303447-3a7jxl34 100 47 , , , cord-303447-3a7jxl34 100 48 education education NN cord-303447-3a7jxl34 100 49 , , , cord-303447-3a7jxl34 100 50 and and CC cord-303447-3a7jxl34 100 51 development development NN cord-303447-3a7jxl34 100 52 programs program NNS cord-303447-3a7jxl34 100 53 . . . cord-303447-3a7jxl34 101 1 Similar similar JJ cord-303447-3a7jxl34 101 2 to to IN cord-303447-3a7jxl34 101 3 all all DT cord-303447-3a7jxl34 101 4 aspects aspect NNS cord-303447-3a7jxl34 101 5 of of IN cord-303447-3a7jxl34 101 6 clinical clinical JJ cord-303447-3a7jxl34 101 7 medicine medicine NN cord-303447-3a7jxl34 101 8 , , , cord-303447-3a7jxl34 101 9 immunization immunization NN cord-303447-3a7jxl34 101 10 recommendations recommendation NNS cord-303447-3a7jxl34 101 11 continuously continuously RB cord-303447-3a7jxl34 101 12 change change VBP cord-303447-3a7jxl34 101 13 as as IN cord-303447-3a7jxl34 101 14 new new JJ cord-303447-3a7jxl34 101 15 vaccines vaccine NNS cord-303447-3a7jxl34 101 16 are be VBP cord-303447-3a7jxl34 101 17 licensed licensed JJ cord-303447-3a7jxl34 101 18 and and CC cord-303447-3a7jxl34 101 19 new new JJ cord-303447-3a7jxl34 101 20 information information NN cord-303447-3a7jxl34 101 21 becomes become VBZ cord-303447-3a7jxl34 101 22 available available JJ cord-303447-3a7jxl34 101 23 . . . cord-303447-3a7jxl34 102 1 Since since IN cord-303447-3a7jxl34 102 2 1990 1990 CD cord-303447-3a7jxl34 102 3 , , , cord-303447-3a7jxl34 102 4 several several JJ cord-303447-3a7jxl34 102 5 new new JJ cord-303447-3a7jxl34 102 6 vaccination vaccination NN cord-303447-3a7jxl34 102 7 recommendations recommendation NNS cord-303447-3a7jxl34 102 8 were be VBD cord-303447-3a7jxl34 102 9 implemented implement VBN cord-303447-3a7jxl34 102 10 for for IN cord-303447-3a7jxl34 102 11 existing exist VBG cord-303447-3a7jxl34 102 12 and and CC cord-303447-3a7jxl34 102 13 new new JJ cord-303447-3a7jxl34 102 14 vaccines vaccine NNS cord-303447-3a7jxl34 102 15 . . . cord-303447-3a7jxl34 103 1 Notable notable JJ cord-303447-3a7jxl34 103 2 examples example NNS cord-303447-3a7jxl34 103 3 are be VBP cord-303447-3a7jxl34 103 4 PCV7 PCV7 NNP cord-303447-3a7jxl34 103 5 and and CC cord-303447-3a7jxl34 103 6 the the DT cord-303447-3a7jxl34 103 7 hepatitis hepatitis NN cord-303447-3a7jxl34 103 8 B B NNP cord-303447-3a7jxl34 103 9 vaccine vaccine NN cord-303447-3a7jxl34 103 10 ; ; : cord-303447-3a7jxl34 103 11 new new JJ cord-303447-3a7jxl34 103 12 recommendations recommendation NNS cord-303447-3a7jxl34 103 13 for for IN cord-303447-3a7jxl34 103 14 both both DT cord-303447-3a7jxl34 103 15 have have VBP cord-303447-3a7jxl34 103 16 affected affect VBN cord-303447-3a7jxl34 103 17 children child NNS cord-303447-3a7jxl34 103 18 and and CC cord-303447-3a7jxl34 103 19 health health NN cord-303447-3a7jxl34 103 20 care care NN cord-303447-3a7jxl34 103 21 providers provider NNS cord-303447-3a7jxl34 103 22 . . . cord-303447-3a7jxl34 104 1 Several several JJ cord-303447-3a7jxl34 104 2 vaccines vaccine NNS cord-303447-3a7jxl34 104 3 with with IN cord-303447-3a7jxl34 104 4 expected expect VBN cord-303447-3a7jxl34 104 5 FDA FDA NNP cord-303447-3a7jxl34 104 6 licensure licensure NN cord-303447-3a7jxl34 104 7 in in IN cord-303447-3a7jxl34 104 8 the the DT cord-303447-3a7jxl34 104 9 near near JJ cord-303447-3a7jxl34 104 10 future future NN cord-303447-3a7jxl34 104 11 likely likely RB cord-303447-3a7jxl34 104 12 will will MD cord-303447-3a7jxl34 104 13 alter alter VB cord-303447-3a7jxl34 104 14 the the DT cord-303447-3a7jxl34 104 15 US US NNP cord-303447-3a7jxl34 104 16 immunization immunization NN cord-303447-3a7jxl34 104 17 program program NN cord-303447-3a7jxl34 104 18 and and CC cord-303447-3a7jxl34 104 19 preventive preventive JJ cord-303447-3a7jxl34 104 20 health health NN cord-303447-3a7jxl34 104 21 care care NN cord-303447-3a7jxl34 104 22 practices practice NNS cord-303447-3a7jxl34 104 23 ( ( -LRB- cord-303447-3a7jxl34 104 24 Table table NN cord-303447-3a7jxl34 104 25 6 6 CD cord-303447-3a7jxl34 104 26 ) ) -RRB- cord-303447-3a7jxl34 104 27 . . . cord-303447-3a7jxl34 105 1 Vaccines vaccine NNS cord-303447-3a7jxl34 105 2 with with IN cord-303447-3a7jxl34 105 3 a a DT cord-303447-3a7jxl34 105 4 pediatric pediatric JJ cord-303447-3a7jxl34 105 5 or or CC cord-303447-3a7jxl34 105 6 adolescent adolescent JJ cord-303447-3a7jxl34 105 7 focus focus NN cord-303447-3a7jxl34 105 8 under under IN cord-303447-3a7jxl34 105 9 review review NN cord-303447-3a7jxl34 105 10 by by IN cord-303447-3a7jxl34 105 11 the the DT cord-303447-3a7jxl34 105 12 ACIP ACIP NNP cord-303447-3a7jxl34 105 13 are be VBP cord-303447-3a7jxl34 105 14 relevant relevant JJ cord-303447-3a7jxl34 105 15 to to IN cord-303447-3a7jxl34 105 16 the the DT cord-303447-3a7jxl34 105 17 prevention prevention NN cord-303447-3a7jxl34 105 18 of of IN cord-303447-3a7jxl34 105 19 pertussis pertussis NN cord-303447-3a7jxl34 105 20 , , , cord-303447-3a7jxl34 105 21 human human JJ cord-303447-3a7jxl34 105 22 papillomavirus papillomavirus NN cord-303447-3a7jxl34 105 23 ( ( -LRB- cord-303447-3a7jxl34 105 24 HPV HPV NNP cord-303447-3a7jxl34 105 25 ) ) -RRB- cord-303447-3a7jxl34 105 26 , , , cord-303447-3a7jxl34 105 27 influenza influenza NN cord-303447-3a7jxl34 105 28 , , , cord-303447-3a7jxl34 105 29 varicella varicella NN cord-303447-3a7jxl34 105 30 , , , cord-303447-3a7jxl34 105 31 and and CC cord-303447-3a7jxl34 105 32 rotavirus rotavirus NN cord-303447-3a7jxl34 105 33 . . . cord-303447-3a7jxl34 106 1 This this DT cord-303447-3a7jxl34 106 2 section section NN cord-303447-3a7jxl34 106 3 presents present VBZ cord-303447-3a7jxl34 106 4 a a DT cord-303447-3a7jxl34 106 5 summary summary NN cord-303447-3a7jxl34 106 6 of of IN cord-303447-3a7jxl34 106 7 these these DT cord-303447-3a7jxl34 106 8 vaccines vaccine NNS cord-303447-3a7jxl34 106 9 in in IN cord-303447-3a7jxl34 106 10 addition addition NN cord-303447-3a7jxl34 106 11 to to IN cord-303447-3a7jxl34 106 12 information information NN cord-303447-3a7jxl34 106 13 on on IN cord-303447-3a7jxl34 106 14 PCV7 PCV7 NNP cord-303447-3a7jxl34 106 15 , , , cord-303447-3a7jxl34 106 16 hepatitis hepatitis NNP cord-303447-3a7jxl34 106 17 B B NNP cord-303447-3a7jxl34 106 18 vaccine vaccine NN cord-303447-3a7jxl34 106 19 , , , cord-303447-3a7jxl34 106 20 and and CC cord-303447-3a7jxl34 106 21 MCV4 MCV4 NNP cord-303447-3a7jxl34 106 22 . . . cord-303447-3a7jxl34 107 1 The the DT cord-303447-3a7jxl34 107 2 potential potential JJ cord-303447-3a7jxl34 107 3 impact impact NN cord-303447-3a7jxl34 107 4 of of IN cord-303447-3a7jxl34 107 5 vaccines vaccine NNS cord-303447-3a7jxl34 107 6 on on IN cord-303447-3a7jxl34 107 7 the the DT cord-303447-3a7jxl34 107 8 distant distant JJ cord-303447-3a7jxl34 107 9 horizon horizon NN cord-303447-3a7jxl34 107 10 also also RB cord-303447-3a7jxl34 107 11 will will MD cord-303447-3a7jxl34 107 12 be be VB cord-303447-3a7jxl34 107 13 highlighted highlight VBN cord-303447-3a7jxl34 107 14 . . . cord-303447-3a7jxl34 108 1 Emphasis emphasis NN cord-303447-3a7jxl34 108 2 is be VBZ cord-303447-3a7jxl34 108 3 on on IN cord-303447-3a7jxl34 108 4 how how WRB cord-303447-3a7jxl34 108 5 recent recent JJ cord-303447-3a7jxl34 108 6 and and CC cord-303447-3a7jxl34 108 7 upcoming upcoming JJ cord-303447-3a7jxl34 108 8 policy policy NN cord-303447-3a7jxl34 108 9 decisions decision NNS cord-303447-3a7jxl34 108 10 might may MD cord-303447-3a7jxl34 108 11 affect affect VB cord-303447-3a7jxl34 108 12 children child NNS cord-303447-3a7jxl34 108 13 and and CC cord-303447-3a7jxl34 108 14 adolescents adolescent NNS cord-303447-3a7jxl34 108 15 , , , cord-303447-3a7jxl34 108 16 health health NN cord-303447-3a7jxl34 108 17 care care NN cord-303447-3a7jxl34 108 18 providers provider NNS cord-303447-3a7jxl34 108 19 , , , cord-303447-3a7jxl34 108 20 and and CC cord-303447-3a7jxl34 108 21 society society NN cord-303447-3a7jxl34 108 22 during during IN cord-303447-3a7jxl34 108 23 the the DT cord-303447-3a7jxl34 108 24 next next JJ cord-303447-3a7jxl34 108 25 decade decade NN cord-303447-3a7jxl34 108 26 . . . cord-303447-3a7jxl34 108 27 _SP cord-303447-3a7jxl34 109 1 PCV7 PCV7 NNP cord-303447-3a7jxl34 109 2 was be VBD cord-303447-3a7jxl34 109 3 recommended recommend VBN cord-303447-3a7jxl34 109 4 for for IN cord-303447-3a7jxl34 109 5 routine routine JJ cord-303447-3a7jxl34 109 6 use use NN cord-303447-3a7jxl34 109 7 in in IN cord-303447-3a7jxl34 109 8 infants infant NNS cord-303447-3a7jxl34 109 9 in in IN cord-303447-3a7jxl34 109 10 the the DT cord-303447-3a7jxl34 109 11 United United NNP cord-303447-3a7jxl34 109 12 States States NNP cord-303447-3a7jxl34 109 13 beginning begin VBG cord-303447-3a7jxl34 109 14 in in IN cord-303447-3a7jxl34 109 15 2000 2000 CD cord-303447-3a7jxl34 109 16 . . . cord-303447-3a7jxl34 110 1 Before before IN cord-303447-3a7jxl34 110 2 introduction introduction NN cord-303447-3a7jxl34 110 3 of of IN cord-303447-3a7jxl34 110 4 PCV7 PCV7 NNP cord-303447-3a7jxl34 110 5 , , , cord-303447-3a7jxl34 110 6 Streptococcus Streptococcus NNP cord-303447-3a7jxl34 110 7 pneumoniae pneumoniae NN cord-303447-3a7jxl34 110 8 ( ( -LRB- cord-303447-3a7jxl34 110 9 pneumococcus pneumococcus NNP cord-303447-3a7jxl34 110 10 ) ) -RRB- cord-303447-3a7jxl34 110 11 was be VBD cord-303447-3a7jxl34 110 12 a a DT cord-303447-3a7jxl34 110 13 leading leading JJ cord-303447-3a7jxl34 110 14 cause cause NN cord-303447-3a7jxl34 110 15 of of IN cord-303447-3a7jxl34 110 16 infectious infectious JJ cord-303447-3a7jxl34 110 17 morbidity morbidity NN cord-303447-3a7jxl34 110 18 in in IN cord-303447-3a7jxl34 110 19 young young JJ cord-303447-3a7jxl34 110 20 children child NNS cord-303447-3a7jxl34 110 21 in in IN cord-303447-3a7jxl34 110 22 the the DT cord-303447-3a7jxl34 110 23 United United NNP cord-303447-3a7jxl34 110 24 States States NNP cord-303447-3a7jxl34 110 25 , , , cord-303447-3a7jxl34 110 26 annually annually RB cord-303447-3a7jxl34 110 27 causing cause VBG cord-303447-3a7jxl34 110 28 approximately approximately RB cord-303447-3a7jxl34 110 29 17,000 17,000 CD cord-303447-3a7jxl34 110 30 cases case NNS cord-303447-3a7jxl34 110 31 of of IN cord-303447-3a7jxl34 110 32 invasive invasive JJ cord-303447-3a7jxl34 110 33 disease disease NN cord-303447-3a7jxl34 110 34 in in IN cord-303447-3a7jxl34 110 35 children child NNS cord-303447-3a7jxl34 110 36 younger young JJR cord-303447-3a7jxl34 110 37 than than IN cord-303447-3a7jxl34 110 38 5 5 CD cord-303447-3a7jxl34 110 39 years year NNS cord-303447-3a7jxl34 110 40 old old JJ cord-303447-3a7jxl34 110 41 , , , cord-303447-3a7jxl34 110 42 including include VBG cord-303447-3a7jxl34 110 43 700 700 CD cord-303447-3a7jxl34 110 44 cases case NNS cord-303447-3a7jxl34 110 45 of of IN cord-303447-3a7jxl34 110 46 meningitis meningitis NN cord-303447-3a7jxl34 110 47 and and CC cord-303447-3a7jxl34 110 48 200 200 CD cord-303447-3a7jxl34 110 49 deaths death NNS cord-303447-3a7jxl34 110 50 . . . cord-303447-3a7jxl34 111 1 In in IN cord-303447-3a7jxl34 111 2 addition addition NN cord-303447-3a7jxl34 111 3 , , , cord-303447-3a7jxl34 111 4 the the DT cord-303447-3a7jxl34 111 5 burden burden NN cord-303447-3a7jxl34 111 6 of of IN cord-303447-3a7jxl34 111 7 pneumonia pneumonia NN cord-303447-3a7jxl34 111 8 without without IN cord-303447-3a7jxl34 111 9 bacteremia bacteremia NN cord-303447-3a7jxl34 111 10 , , , cord-303447-3a7jxl34 111 11 otitis otitis NN cord-303447-3a7jxl34 111 12 media medium NNS cord-303447-3a7jxl34 111 13 , , , cord-303447-3a7jxl34 111 14 and and CC cord-303447-3a7jxl34 111 15 sinusitis sinusitis NN cord-303447-3a7jxl34 111 16 was be VBD cord-303447-3a7jxl34 111 17 substantial substantial JJ cord-303447-3a7jxl34 111 18 [ [ -LRB- cord-303447-3a7jxl34 111 19 36 36 CD cord-303447-3a7jxl34 111 20 ] ] -RRB- cord-303447-3a7jxl34 111 21 . . . cord-303447-3a7jxl34 112 1 After after IN cord-303447-3a7jxl34 112 2 introduction introduction NN cord-303447-3a7jxl34 112 3 of of IN cord-303447-3a7jxl34 112 4 routine routine JJ cord-303447-3a7jxl34 112 5 PCV7 PCV7 NNP cord-303447-3a7jxl34 112 6 vaccination vaccination NN cord-303447-3a7jxl34 112 7 , , , cord-303447-3a7jxl34 112 8 the the DT cord-303447-3a7jxl34 112 9 incidence incidence NN cord-303447-3a7jxl34 112 10 of of IN cord-303447-3a7jxl34 112 11 invasive invasive JJ cord-303447-3a7jxl34 112 12 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 112 13 disease disease NN cord-303447-3a7jxl34 112 14 declined decline VBD cord-303447-3a7jxl34 112 15 dramatically dramatically RB cord-303447-3a7jxl34 112 16 , , , cord-303447-3a7jxl34 112 17 especially especially RB cord-303447-3a7jxl34 112 18 in in IN cord-303447-3a7jxl34 112 19 children child NNS cord-303447-3a7jxl34 112 20 younger young JJR cord-303447-3a7jxl34 112 21 than than IN cord-303447-3a7jxl34 112 22 2 2 CD cord-303447-3a7jxl34 112 23 years year NNS cord-303447-3a7jxl34 112 24 old old JJ cord-303447-3a7jxl34 112 25 [ [ -LRB- cord-303447-3a7jxl34 112 26 37 37 CD cord-303447-3a7jxl34 112 27 ] ] -RRB- cord-303447-3a7jxl34 112 28 [ [ -LRB- cord-303447-3a7jxl34 112 29 38 38 CD cord-303447-3a7jxl34 112 30 ] ] -RRB- cord-303447-3a7jxl34 112 31 [ [ -LRB- cord-303447-3a7jxl34 112 32 39 39 CD cord-303447-3a7jxl34 112 33 ] ] -RRB- cord-303447-3a7jxl34 112 34 . . . cord-303447-3a7jxl34 113 1 Active active JJ cord-303447-3a7jxl34 113 2 US US NNP cord-303447-3a7jxl34 113 3 population population NN cord-303447-3a7jxl34 113 4 - - HYPH cord-303447-3a7jxl34 113 5 based base VBN cord-303447-3a7jxl34 113 6 surveillance surveillance NN cord-303447-3a7jxl34 113 7 data datum NNS cord-303447-3a7jxl34 113 8 show show VBP cord-303447-3a7jxl34 113 9 that that IN cord-303447-3a7jxl34 113 10 within within IN cord-303447-3a7jxl34 113 11 2 2 CD cord-303447-3a7jxl34 113 12 years year NNS cord-303447-3a7jxl34 113 13 of of IN cord-303447-3a7jxl34 113 14 PCV7 PCV7 NNP cord-303447-3a7jxl34 113 15 licensure licensure NN cord-303447-3a7jxl34 113 16 , , , cord-303447-3a7jxl34 113 17 the the DT cord-303447-3a7jxl34 113 18 rate rate NN cord-303447-3a7jxl34 113 19 of of IN cord-303447-3a7jxl34 113 20 invasive invasive JJ cord-303447-3a7jxl34 113 21 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 113 22 disease disease NN cord-303447-3a7jxl34 113 23 in in IN cord-303447-3a7jxl34 113 24 children child NNS cord-303447-3a7jxl34 113 25 younger young JJR cord-303447-3a7jxl34 113 26 than than IN cord-303447-3a7jxl34 113 27 2 2 CD cord-303447-3a7jxl34 113 28 years year NNS cord-303447-3a7jxl34 113 29 old old JJ cord-303447-3a7jxl34 113 30 declined decline VBD cord-303447-3a7jxl34 113 31 by by IN cord-303447-3a7jxl34 113 32 69 69 CD cord-303447-3a7jxl34 113 33 % % NN cord-303447-3a7jxl34 113 34 [ [ -LRB- cord-303447-3a7jxl34 113 35 39 39 CD cord-303447-3a7jxl34 113 36 ] ] -RRB- cord-303447-3a7jxl34 113 37 . . . cord-303447-3a7jxl34 114 1 In in IN cord-303447-3a7jxl34 114 2 tandem tandem NN cord-303447-3a7jxl34 114 3 with with IN cord-303447-3a7jxl34 114 4 the the DT cord-303447-3a7jxl34 114 5 decrease decrease NN cord-303447-3a7jxl34 114 6 in in IN cord-303447-3a7jxl34 114 7 invasive invasive JJ cord-303447-3a7jxl34 114 8 disease disease NN cord-303447-3a7jxl34 114 9 , , , cord-303447-3a7jxl34 114 10 data datum NNS cord-303447-3a7jxl34 114 11 suggest suggest VBP cord-303447-3a7jxl34 114 12 the the DT cord-303447-3a7jxl34 114 13 incidence incidence NN cord-303447-3a7jxl34 114 14 of of IN cord-303447-3a7jxl34 114 15 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 114 16 noninvasive noninvasive JJ cord-303447-3a7jxl34 114 17 disease disease NN cord-303447-3a7jxl34 114 18 , , , cord-303447-3a7jxl34 114 19 including include VBG cord-303447-3a7jxl34 114 20 otitis otitis NN cord-303447-3a7jxl34 114 21 media medium NNS cord-303447-3a7jxl34 114 22 , , , cord-303447-3a7jxl34 114 23 also also RB cord-303447-3a7jxl34 114 24 decreased decrease VBD cord-303447-3a7jxl34 114 25 [ [ -LRB- cord-303447-3a7jxl34 114 26 40 40 CD cord-303447-3a7jxl34 114 27 , , , cord-303447-3a7jxl34 114 28 41 41 CD cord-303447-3a7jxl34 114 29 ] ] -RRB- cord-303447-3a7jxl34 114 30 . . . cord-303447-3a7jxl34 115 1 In in IN cord-303447-3a7jxl34 115 2 addition addition NN cord-303447-3a7jxl34 115 3 to to IN cord-303447-3a7jxl34 115 4 decreasing decrease VBG cord-303447-3a7jxl34 115 5 the the DT cord-303447-3a7jxl34 115 6 burden burden NN cord-303447-3a7jxl34 115 7 of of IN cord-303447-3a7jxl34 115 8 pediatric pediatric JJ cord-303447-3a7jxl34 115 9 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 115 10 disease disease NN cord-303447-3a7jxl34 115 11 , , , cord-303447-3a7jxl34 115 12 PCV7 PCV7 NNP cord-303447-3a7jxl34 115 13 may may MD cord-303447-3a7jxl34 115 14 have have VB cord-303447-3a7jxl34 115 15 an an DT cord-303447-3a7jxl34 115 16 impact impact NN cord-303447-3a7jxl34 115 17 on on IN cord-303447-3a7jxl34 115 18 reducing reduce VBG cord-303447-3a7jxl34 115 19 pediatric pediatric JJ cord-303447-3a7jxl34 115 20 antibiotic antibiotic JJ cord-303447-3a7jxl34 115 21 prescriptions prescription NNS cord-303447-3a7jxl34 115 22 and and CC cord-303447-3a7jxl34 115 23 procedures procedure NNS cord-303447-3a7jxl34 115 24 such such JJ cord-303447-3a7jxl34 115 25 as as IN cord-303447-3a7jxl34 115 26 blood blood NN cord-303447-3a7jxl34 115 27 cultures culture NNS cord-303447-3a7jxl34 115 28 in in IN cord-303447-3a7jxl34 115 29 young young JJ cord-303447-3a7jxl34 115 30 , , , cord-303447-3a7jxl34 115 31 febrile febrile JJ cord-303447-3a7jxl34 115 32 children child NNS cord-303447-3a7jxl34 115 33 [ [ -LRB- cord-303447-3a7jxl34 115 34 42 42 CD cord-303447-3a7jxl34 115 35 ] ] -RRB- cord-303447-3a7jxl34 115 36 . . . cord-303447-3a7jxl34 116 1 The the DT cord-303447-3a7jxl34 116 2 decline decline NN cord-303447-3a7jxl34 116 3 in in IN cord-303447-3a7jxl34 116 4 invasive invasive JJ cord-303447-3a7jxl34 116 5 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 116 6 disease disease NN cord-303447-3a7jxl34 116 7 is be VBZ cord-303447-3a7jxl34 116 8 beyond beyond IN cord-303447-3a7jxl34 116 9 what what WP cord-303447-3a7jxl34 116 10 would would MD cord-303447-3a7jxl34 116 11 be be VB cord-303447-3a7jxl34 116 12 expected expect VBN cord-303447-3a7jxl34 116 13 from from IN cord-303447-3a7jxl34 116 14 childhood childhood NN cord-303447-3a7jxl34 116 15 vaccination vaccination NN cord-303447-3a7jxl34 116 16 , , , cord-303447-3a7jxl34 116 17 given give VBN cord-303447-3a7jxl34 116 18 vaccine vaccine NN cord-303447-3a7jxl34 116 19 efficacy efficacy NN cord-303447-3a7jxl34 116 20 and and CC cord-303447-3a7jxl34 116 21 PCV7 PCV7 NNP cord-303447-3a7jxl34 116 22 coverage coverage NN cord-303447-3a7jxl34 116 23 data datum NNS cord-303447-3a7jxl34 116 24 , , , cord-303447-3a7jxl34 116 25 suggesting suggest VBG cord-303447-3a7jxl34 116 26 that that IN cord-303447-3a7jxl34 116 27 herd herd NN cord-303447-3a7jxl34 116 28 immunity immunity NN cord-303447-3a7jxl34 116 29 may may MD cord-303447-3a7jxl34 116 30 play play VB cord-303447-3a7jxl34 116 31 a a DT cord-303447-3a7jxl34 116 32 role role NN cord-303447-3a7jxl34 116 33 in in IN cord-303447-3a7jxl34 116 34 protecting protect VBG cord-303447-3a7jxl34 116 35 unimmunized unimmunized JJ cord-303447-3a7jxl34 116 36 people people NNS cord-303447-3a7jxl34 116 37 from from IN cord-303447-3a7jxl34 116 38 invasive invasive JJ cord-303447-3a7jxl34 116 39 disease disease NN cord-303447-3a7jxl34 116 40 [ [ -LRB- cord-303447-3a7jxl34 116 41 37 37 CD cord-303447-3a7jxl34 116 42 ] ] -RRB- cord-303447-3a7jxl34 116 43 . . . cord-303447-3a7jxl34 117 1 Reduced reduce VBN cord-303447-3a7jxl34 117 2 nasopharyngeal nasopharyngeal JJ cord-303447-3a7jxl34 117 3 carriage carriage NN cord-303447-3a7jxl34 117 4 of of IN cord-303447-3a7jxl34 117 5 vaccinecontaining vaccinecontaine VBG cord-303447-3a7jxl34 117 6 serotypes serotype NNS cord-303447-3a7jxl34 117 7 in in IN cord-303447-3a7jxl34 117 8 vaccinated vaccinated JJ cord-303447-3a7jxl34 117 9 children child NNS cord-303447-3a7jxl34 117 10 is be VBZ cord-303447-3a7jxl34 117 11 believed believe VBN cord-303447-3a7jxl34 117 12 to to TO cord-303447-3a7jxl34 117 13 contribute contribute VB cord-303447-3a7jxl34 117 14 to to IN cord-303447-3a7jxl34 117 15 development development NN cord-303447-3a7jxl34 117 16 of of IN cord-303447-3a7jxl34 117 17 herd herd NN cord-303447-3a7jxl34 117 18 immunity immunity NN cord-303447-3a7jxl34 117 19 against against IN cord-303447-3a7jxl34 117 20 pneumococcus pneumococcus NNP cord-303447-3a7jxl34 117 21 . . . cord-303447-3a7jxl34 118 1 Rates rate NNS cord-303447-3a7jxl34 118 2 of of IN cord-303447-3a7jxl34 118 3 invasive invasive JJ cord-303447-3a7jxl34 118 4 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 118 5 disease disease NN cord-303447-3a7jxl34 118 6 seem seem VBP cord-303447-3a7jxl34 118 7 to to TO cord-303447-3a7jxl34 118 8 be be VB cord-303447-3a7jxl34 118 9 declining decline VBG cord-303447-3a7jxl34 118 10 among among IN cord-303447-3a7jxl34 118 11 some some DT cord-303447-3a7jxl34 118 12 unvaccinated unvaccinated JJ cord-303447-3a7jxl34 118 13 groups group NNS cord-303447-3a7jxl34 118 14 after after IN cord-303447-3a7jxl34 118 15 implementation implementation NN cord-303447-3a7jxl34 118 16 of of IN cord-303447-3a7jxl34 118 17 universal universal JJ cord-303447-3a7jxl34 118 18 infant infant NN cord-303447-3a7jxl34 118 19 PCV7 PCV7 NNP cord-303447-3a7jxl34 118 20 vaccination vaccination NN cord-303447-3a7jxl34 118 21 . . . cord-303447-3a7jxl34 119 1 In in IN cord-303447-3a7jxl34 119 2 addition addition NN cord-303447-3a7jxl34 119 3 , , , cord-303447-3a7jxl34 119 4 postlicensure postlicensure NN cord-303447-3a7jxl34 119 5 surveillance surveillance NN cord-303447-3a7jxl34 119 6 data datum NNS cord-303447-3a7jxl34 119 7 suggest suggest VBP cord-303447-3a7jxl34 119 8 a a DT cord-303447-3a7jxl34 119 9 decrease decrease NN cord-303447-3a7jxl34 119 10 in in IN cord-303447-3a7jxl34 119 11 antibiotic antibiotic JJ cord-303447-3a7jxl34 119 12 - - HYPH cord-303447-3a7jxl34 119 13 resistant resistant JJ cord-303447-3a7jxl34 119 14 strains strain NNS cord-303447-3a7jxl34 119 15 of of IN cord-303447-3a7jxl34 119 16 S. S. NNP cord-303447-3a7jxl34 119 17 pneumoniae pneumoniae NN cord-303447-3a7jxl34 119 18 [ [ -LRB- cord-303447-3a7jxl34 119 19 37 37 CD cord-303447-3a7jxl34 119 20 , , , cord-303447-3a7jxl34 119 21 39 39 CD cord-303447-3a7jxl34 119 22 ] ] -RRB- cord-303447-3a7jxl34 119 23 . . . cord-303447-3a7jxl34 120 1 Because because IN cord-303447-3a7jxl34 120 2 PCV7 PCV7 NNP cord-303447-3a7jxl34 120 3 includes include VBZ cord-303447-3a7jxl34 120 4 only only RB cord-303447-3a7jxl34 120 5 7 7 CD cord-303447-3a7jxl34 120 6 of of IN cord-303447-3a7jxl34 120 7 the the DT cord-303447-3a7jxl34 120 8 more more JJR cord-303447-3a7jxl34 120 9 than than IN cord-303447-3a7jxl34 120 10 90 90 CD cord-303447-3a7jxl34 120 11 serotypes serotype NNS cord-303447-3a7jxl34 120 12 of of IN cord-303447-3a7jxl34 120 13 pneumococcus pneumococcus NN cord-303447-3a7jxl34 120 14 , , , cord-303447-3a7jxl34 120 15 there there EX cord-303447-3a7jxl34 120 16 is be VBZ cord-303447-3a7jxl34 120 17 theoretical theoretical JJ cord-303447-3a7jxl34 120 18 concern concern NN cord-303447-3a7jxl34 120 19 that that DT cord-303447-3a7jxl34 120 20 serotype serotype NN cord-303447-3a7jxl34 120 21 replacement replacement NN cord-303447-3a7jxl34 120 22 might may MD cord-303447-3a7jxl34 120 23 occur occur VB cord-303447-3a7jxl34 120 24 in in IN cord-303447-3a7jxl34 120 25 highly highly RB cord-303447-3a7jxl34 120 26 vaccinated vaccinate VBN cord-303447-3a7jxl34 120 27 populations population NNS cord-303447-3a7jxl34 120 28 . . . cord-303447-3a7jxl34 121 1 One one CD cord-303447-3a7jxl34 121 2 study study NN cord-303447-3a7jxl34 121 3 noted note VBD cord-303447-3a7jxl34 121 4 an an DT cord-303447-3a7jxl34 121 5 increase increase NN cord-303447-3a7jxl34 121 6 in in IN cord-303447-3a7jxl34 121 7 the the DT cord-303447-3a7jxl34 121 8 proportion proportion NN cord-303447-3a7jxl34 121 9 of of IN cord-303447-3a7jxl34 121 10 cases case NNS cord-303447-3a7jxl34 121 11 of of IN cord-303447-3a7jxl34 121 12 invasive invasive JJ cord-303447-3a7jxl34 121 13 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 121 14 disease disease NN cord-303447-3a7jxl34 121 15 resulting result VBG cord-303447-3a7jxl34 121 16 from from IN cord-303447-3a7jxl34 121 17 nonvaccine nonvaccine NNP cord-303447-3a7jxl34 121 18 serotypes serotype NNS cord-303447-3a7jxl34 121 19 , , , cord-303447-3a7jxl34 121 20 but but CC cord-303447-3a7jxl34 121 21 the the DT cord-303447-3a7jxl34 121 22 total total JJ cord-303447-3a7jxl34 121 23 number number NN cord-303447-3a7jxl34 121 24 of of IN cord-303447-3a7jxl34 121 25 cases case NNS cord-303447-3a7jxl34 121 26 was be VBD cord-303447-3a7jxl34 121 27 not not RB cord-303447-3a7jxl34 121 28 changed change VBN cord-303447-3a7jxl34 121 29 [ [ -LRB- cord-303447-3a7jxl34 121 30 38 38 CD cord-303447-3a7jxl34 121 31 ] ] -RRB- cord-303447-3a7jxl34 121 32 . . . cord-303447-3a7jxl34 122 1 This this DT cord-303447-3a7jxl34 122 2 study study NN cord-303447-3a7jxl34 122 3 supports support VBZ cord-303447-3a7jxl34 122 4 the the DT cord-303447-3a7jxl34 122 5 need need NN cord-303447-3a7jxl34 122 6 for for IN cord-303447-3a7jxl34 122 7 continued continued JJ cord-303447-3a7jxl34 122 8 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 122 9 surveillance surveillance NN cord-303447-3a7jxl34 122 10 in in IN cord-303447-3a7jxl34 122 11 the the DT cord-303447-3a7jxl34 122 12 post post JJ cord-303447-3a7jxl34 122 13 - - JJ cord-303447-3a7jxl34 122 14 PCV7 pcv7 JJ cord-303447-3a7jxl34 122 15 era era NN cord-303447-3a7jxl34 122 16 [ [ -LRB- cord-303447-3a7jxl34 122 17 43 43 CD cord-303447-3a7jxl34 122 18 ] ] -RRB- cord-303447-3a7jxl34 122 19 . . . cord-303447-3a7jxl34 123 1 Hepatitis Hepatitis NNP cord-303447-3a7jxl34 123 2 B B NNP cord-303447-3a7jxl34 123 3 vaccine vaccine NN cord-303447-3a7jxl34 123 4 holds hold VBZ cord-303447-3a7jxl34 123 5 a a DT cord-303447-3a7jxl34 123 6 unique unique JJ cord-303447-3a7jxl34 123 7 place place NN cord-303447-3a7jxl34 123 8 in in IN cord-303447-3a7jxl34 123 9 the the DT cord-303447-3a7jxl34 123 10 US US NNP cord-303447-3a7jxl34 123 11 immunization immunization NN cord-303447-3a7jxl34 123 12 schedule schedule NN cord-303447-3a7jxl34 123 13 because because IN cord-303447-3a7jxl34 123 14 they -PRON- PRP cord-303447-3a7jxl34 123 15 are be VBP cord-303447-3a7jxl34 123 16 the the DT cord-303447-3a7jxl34 123 17 only only JJ cord-303447-3a7jxl34 123 18 vaccines vaccine NNS cord-303447-3a7jxl34 123 19 licensed license VBN cord-303447-3a7jxl34 123 20 for for IN cord-303447-3a7jxl34 123 21 neonates neonate NNS cord-303447-3a7jxl34 123 22 and and CC cord-303447-3a7jxl34 123 23 the the DT cord-303447-3a7jxl34 123 24 only only JJ cord-303447-3a7jxl34 123 25 licensed licensed JJ cord-303447-3a7jxl34 123 26 vaccine vaccine NN cord-303447-3a7jxl34 123 27 that that WDT cord-303447-3a7jxl34 123 28 prevents prevent VBZ cord-303447-3a7jxl34 123 29 cancer cancer NN cord-303447-3a7jxl34 123 30 . . . cord-303447-3a7jxl34 124 1 The the DT cord-303447-3a7jxl34 124 2 continued continued JJ cord-303447-3a7jxl34 124 3 evolution evolution NN cord-303447-3a7jxl34 124 4 of of IN cord-303447-3a7jxl34 124 5 hepatitis hepatitis NNP cord-303447-3a7jxl34 124 6 B B NNP cord-303447-3a7jxl34 124 7 vaccine vaccine NN cord-303447-3a7jxl34 124 8 recommendations recommendation NNS cord-303447-3a7jxl34 124 9 reflects reflect VBZ cord-303447-3a7jxl34 124 10 many many JJ cord-303447-3a7jxl34 124 11 of of IN cord-303447-3a7jxl34 124 12 the the DT cord-303447-3a7jxl34 124 13 challenges challenge NNS cord-303447-3a7jxl34 124 14 associated associate VBN cord-303447-3a7jxl34 124 15 with with IN cord-303447-3a7jxl34 124 16 vaccines vaccine NNS cord-303447-3a7jxl34 124 17 that that WDT cord-303447-3a7jxl34 124 18 will will MD cord-303447-3a7jxl34 124 19 be be VB cord-303447-3a7jxl34 124 20 licensed license VBN cord-303447-3a7jxl34 124 21 in in IN cord-303447-3a7jxl34 124 22 the the DT cord-303447-3a7jxl34 124 23 near near JJ cord-303447-3a7jxl34 124 24 future future NN cord-303447-3a7jxl34 124 25 . . . cord-303447-3a7jxl34 125 1 Before before IN cord-303447-3a7jxl34 125 2 1982 1982 CD cord-303447-3a7jxl34 125 3 , , , cord-303447-3a7jxl34 125 4 an an DT cord-303447-3a7jxl34 125 5 estimated estimate VBN cord-303447-3a7jxl34 125 6 200,000 200,000 CD cord-303447-3a7jxl34 125 7 to to TO cord-303447-3a7jxl34 125 8 300,000 300,000 CD cord-303447-3a7jxl34 125 9 people people NNS cord-303447-3a7jxl34 125 10 in in IN cord-303447-3a7jxl34 125 11 the the DT cord-303447-3a7jxl34 125 12 United United NNP cord-303447-3a7jxl34 125 13 States States NNP cord-303447-3a7jxl34 125 14 were be VBD cord-303447-3a7jxl34 125 15 infected infect VBN cord-303447-3a7jxl34 125 16 annually annually RB cord-303447-3a7jxl34 125 17 with with IN cord-303447-3a7jxl34 125 18 hepatitis hepatitis NN cord-303447-3a7jxl34 125 19 B B NNP cord-303447-3a7jxl34 125 20 virus virus NN cord-303447-3a7jxl34 125 21 , , , cord-303447-3a7jxl34 125 22 including include VBG cord-303447-3a7jxl34 125 23 approximately approximately RB cord-303447-3a7jxl34 125 24 20,000 20,000 CD cord-303447-3a7jxl34 125 25 children child NNS cord-303447-3a7jxl34 125 26 [ [ -LRB- cord-303447-3a7jxl34 125 27 44 44 CD cord-303447-3a7jxl34 125 28 ] ] -RRB- cord-303447-3a7jxl34 125 29 . . . cord-303447-3a7jxl34 126 1 Although although IN cord-303447-3a7jxl34 126 2 most most JJS cord-303447-3a7jxl34 126 3 vaccine vaccine NN cord-303447-3a7jxl34 126 4 - - HYPH cord-303447-3a7jxl34 126 5 preventable preventable JJ cord-303447-3a7jxl34 126 6 diseases disease NNS cord-303447-3a7jxl34 126 7 are be VBP cord-303447-3a7jxl34 126 8 spread spread VBN cord-303447-3a7jxl34 126 9 via via IN cord-303447-3a7jxl34 126 10 contact contact NN cord-303447-3a7jxl34 126 11 or or CC cord-303447-3a7jxl34 126 12 airborne airborne JJ cord-303447-3a7jxl34 126 13 droplets droplet NNS cord-303447-3a7jxl34 126 14 , , , cord-303447-3a7jxl34 126 15 hepatitis hepatitis NN cord-303447-3a7jxl34 126 16 B b NN cord-303447-3a7jxl34 126 17 infection infection NN cord-303447-3a7jxl34 126 18 is be VBZ cord-303447-3a7jxl34 126 19 spread spread VBN cord-303447-3a7jxl34 126 20 via via IN cord-303447-3a7jxl34 126 21 exposure exposure NN cord-303447-3a7jxl34 126 22 to to IN cord-303447-3a7jxl34 126 23 infected infected JJ cord-303447-3a7jxl34 126 24 blood blood NN cord-303447-3a7jxl34 126 25 or or CC cord-303447-3a7jxl34 126 26 blood blood NN cord-303447-3a7jxl34 126 27 products product NNS cord-303447-3a7jxl34 126 28 , , , cord-303447-3a7jxl34 126 29 sexual sexual JJ cord-303447-3a7jxl34 126 30 contact contact NN cord-303447-3a7jxl34 126 31 , , , cord-303447-3a7jxl34 126 32 and and CC cord-303447-3a7jxl34 126 33 injection injection NN cord-303447-3a7jxl34 126 34 devices device NNS cord-303447-3a7jxl34 126 35 . . . cord-303447-3a7jxl34 127 1 Much much JJ cord-303447-3a7jxl34 127 2 of of IN cord-303447-3a7jxl34 127 3 the the DT cord-303447-3a7jxl34 127 4 transmission transmission NN cord-303447-3a7jxl34 127 5 of of IN cord-303447-3a7jxl34 127 6 hepatitis hepatitis NN cord-303447-3a7jxl34 127 7 B B NNP cord-303447-3a7jxl34 127 8 in in IN cord-303447-3a7jxl34 127 9 adults adult NNS cord-303447-3a7jxl34 127 10 is be VBZ cord-303447-3a7jxl34 127 11 silent silent JJ cord-303447-3a7jxl34 127 12 ; ; : cord-303447-3a7jxl34 127 13 there there EX cord-303447-3a7jxl34 127 14 is be VBZ cord-303447-3a7jxl34 127 15 no no DT cord-303447-3a7jxl34 127 16 accompanying accompany VBG cord-303447-3a7jxl34 127 17 rash rash NN cord-303447-3a7jxl34 127 18 or or CC cord-303447-3a7jxl34 127 19 symptoms symptom NNS cord-303447-3a7jxl34 127 20 . . . cord-303447-3a7jxl34 128 1 Although although IN cord-303447-3a7jxl34 128 2 adults adult NNS cord-303447-3a7jxl34 128 3 have have VBP cord-303447-3a7jxl34 128 4 a a DT cord-303447-3a7jxl34 128 5 10 10 CD cord-303447-3a7jxl34 128 6 % % NN cord-303447-3a7jxl34 128 7 chance chance NN cord-303447-3a7jxl34 128 8 of of IN cord-303447-3a7jxl34 128 9 developing develop VBG cord-303447-3a7jxl34 128 10 chronic chronic JJ cord-303447-3a7jxl34 128 11 hepatitis hepatitis NN cord-303447-3a7jxl34 128 12 B b NN cord-303447-3a7jxl34 128 13 virus virus NN cord-303447-3a7jxl34 128 14 infection infection NN cord-303447-3a7jxl34 128 15 , , , cord-303447-3a7jxl34 128 16 infants infant NNS cord-303447-3a7jxl34 128 17 infected infect VBN cord-303447-3a7jxl34 128 18 perinatally perinatally RB cord-303447-3a7jxl34 128 19 who who WP cord-303447-3a7jxl34 128 20 do do VBP cord-303447-3a7jxl34 128 21 not not RB cord-303447-3a7jxl34 128 22 receive receive VB cord-303447-3a7jxl34 128 23 hepatitis hepatitis NN cord-303447-3a7jxl34 128 24 B B NNP cord-303447-3a7jxl34 128 25 immunoglobulin immunoglobulin NN cord-303447-3a7jxl34 128 26 and and CC cord-303447-3a7jxl34 128 27 vaccine vaccine NN cord-303447-3a7jxl34 128 28 at at IN cord-303447-3a7jxl34 128 29 birth birth NN cord-303447-3a7jxl34 129 1 have have VB cord-303447-3a7jxl34 129 2 a a DT cord-303447-3a7jxl34 129 3 90 90 CD cord-303447-3a7jxl34 129 4 % % NN cord-303447-3a7jxl34 129 5 chance chance NN cord-303447-3a7jxl34 129 6 of of IN cord-303447-3a7jxl34 129 7 developing develop VBG cord-303447-3a7jxl34 129 8 chronic chronic JJ cord-303447-3a7jxl34 129 9 infection infection NN cord-303447-3a7jxl34 129 10 . . . cord-303447-3a7jxl34 130 1 Twenty twenty CD cord-303447-3a7jxl34 130 2 - - HYPH cord-303447-3a7jxl34 130 3 five five CD cord-303447-3a7jxl34 130 4 percent percent NN cord-303447-3a7jxl34 130 5 of of IN cord-303447-3a7jxl34 130 6 these these DT cord-303447-3a7jxl34 130 7 infections infection NNS cord-303447-3a7jxl34 130 8 lead lead VBP cord-303447-3a7jxl34 130 9 to to IN cord-303447-3a7jxl34 130 10 hepatocellular hepatocellular JJ cord-303447-3a7jxl34 130 11 carcinoma carcinoma NN cord-303447-3a7jxl34 130 12 [ [ -LRB- cord-303447-3a7jxl34 130 13 45 45 CD cord-303447-3a7jxl34 130 14 ] ] -RRB- cord-303447-3a7jxl34 130 15 . . . cord-303447-3a7jxl34 131 1 The the DT cord-303447-3a7jxl34 131 2 complexity complexity NN cord-303447-3a7jxl34 131 3 of of IN cord-303447-3a7jxl34 131 4 hepatitis hepatitis NN cord-303447-3a7jxl34 131 5 B b NN cord-303447-3a7jxl34 131 6 transmission transmission NN cord-303447-3a7jxl34 131 7 required require VBD cord-303447-3a7jxl34 131 8 a a DT cord-303447-3a7jxl34 131 9 vaccination vaccination NN cord-303447-3a7jxl34 131 10 strategy strategy NN cord-303447-3a7jxl34 131 11 to to TO cord-303447-3a7jxl34 131 12 protect protect VB cord-303447-3a7jxl34 131 13 infants infant NNS cord-303447-3a7jxl34 131 14 and and CC cord-303447-3a7jxl34 131 15 high high JJ cord-303447-3a7jxl34 131 16 - - HYPH cord-303447-3a7jxl34 131 17 risk risk NN cord-303447-3a7jxl34 131 18 adults adult NNS cord-303447-3a7jxl34 131 19 from from IN cord-303447-3a7jxl34 131 20 infection infection NN cord-303447-3a7jxl34 131 21 . . . cord-303447-3a7jxl34 132 1 The the DT cord-303447-3a7jxl34 132 2 first first JJ cord-303447-3a7jxl34 132 3 ACIP ACIP NNP cord-303447-3a7jxl34 132 4 hepatitis hepatitis NN cord-303447-3a7jxl34 132 5 B B NNP cord-303447-3a7jxl34 132 6 recommendation recommendation NN cord-303447-3a7jxl34 132 7 in in IN cord-303447-3a7jxl34 132 8 1982 1982 CD cord-303447-3a7jxl34 132 9 was be VBD cord-303447-3a7jxl34 132 10 to to TO cord-303447-3a7jxl34 132 11 vaccinate vaccinate VB cord-303447-3a7jxl34 132 12 groups group NNS cord-303447-3a7jxl34 132 13 known know VBN cord-303447-3a7jxl34 132 14 to to TO cord-303447-3a7jxl34 132 15 be be VB cord-303447-3a7jxl34 132 16 at at IN cord-303447-3a7jxl34 132 17 high high JJ cord-303447-3a7jxl34 132 18 risk risk NN cord-303447-3a7jxl34 132 19 for for IN cord-303447-3a7jxl34 132 20 hepatitis hepatitis NN cord-303447-3a7jxl34 132 21 B B NNP cord-303447-3a7jxl34 132 22 virus virus NN cord-303447-3a7jxl34 132 23 infection infection NN cord-303447-3a7jxl34 132 24 , , , cord-303447-3a7jxl34 132 25 such such JJ cord-303447-3a7jxl34 132 26 as as IN cord-303447-3a7jxl34 132 27 health health NN cord-303447-3a7jxl34 132 28 care care NN cord-303447-3a7jxl34 132 29 workers worker NNS cord-303447-3a7jxl34 132 30 , , , cord-303447-3a7jxl34 132 31 men man NNS cord-303447-3a7jxl34 132 32 who who WP cord-303447-3a7jxl34 132 33 have have VBP cord-303447-3a7jxl34 132 34 sex sex NN cord-303447-3a7jxl34 132 35 with with IN cord-303447-3a7jxl34 132 36 men man NNS cord-303447-3a7jxl34 132 37 , , , cord-303447-3a7jxl34 132 38 and and CC cord-303447-3a7jxl34 132 39 intravenous intravenous JJ cord-303447-3a7jxl34 132 40 drug drug NN cord-303447-3a7jxl34 132 41 users user NNS cord-303447-3a7jxl34 132 42 [ [ -LRB- cord-303447-3a7jxl34 132 43 46 46 CD cord-303447-3a7jxl34 132 44 ] ] -RRB- cord-303447-3a7jxl34 132 45 . . . cord-303447-3a7jxl34 133 1 In in IN cord-303447-3a7jxl34 133 2 1984 1984 CD cord-303447-3a7jxl34 133 3 , , , cord-303447-3a7jxl34 133 4 the the DT cord-303447-3a7jxl34 133 5 ACIP ACIP NNP cord-303447-3a7jxl34 133 6 expanded expand VBD cord-303447-3a7jxl34 133 7 recommendations recommendation NNS cord-303447-3a7jxl34 133 8 to to TO cord-303447-3a7jxl34 133 9 include include VB cord-303447-3a7jxl34 133 10 infants infant NNS cord-303447-3a7jxl34 133 11 born bear VBN cord-303447-3a7jxl34 133 12 to to IN cord-303447-3a7jxl34 133 13 mothers mother NNS cord-303447-3a7jxl34 133 14 who who WP cord-303447-3a7jxl34 133 15 were be VBD cord-303447-3a7jxl34 133 16 hepatitis hepatitis NNP cord-303447-3a7jxl34 133 17 B B NNP cord-303447-3a7jxl34 133 18 surface surface NN cord-303447-3a7jxl34 133 19 antigen antigen NN cord-303447-3a7jxl34 133 20 ( ( -LRB- cord-303447-3a7jxl34 133 21 HBsAg HBsAg NNP cord-303447-3a7jxl34 133 22 ) ) -RRB- cord-303447-3a7jxl34 133 23 positive positive JJ cord-303447-3a7jxl34 133 24 . . . cord-303447-3a7jxl34 134 1 Recognition recognition NN cord-303447-3a7jxl34 134 2 of of IN cord-303447-3a7jxl34 134 3 the the DT cord-303447-3a7jxl34 134 4 difficulty difficulty NN cord-303447-3a7jxl34 134 5 in in IN cord-303447-3a7jxl34 134 6 identifying identify VBG cord-303447-3a7jxl34 134 7 mothers mother NNS cord-303447-3a7jxl34 134 8 infected infect VBN cord-303447-3a7jxl34 134 9 with with IN cord-303447-3a7jxl34 134 10 hepatitis hepatitis NN cord-303447-3a7jxl34 134 11 B B NNP cord-303447-3a7jxl34 134 12 led lead VBD cord-303447-3a7jxl34 134 13 to to IN cord-303447-3a7jxl34 134 14 a a DT cord-303447-3a7jxl34 134 15 recommendation recommendation NN cord-303447-3a7jxl34 134 16 in in IN cord-303447-3a7jxl34 134 17 1988 1988 CD cord-303447-3a7jxl34 134 18 to to TO cord-303447-3a7jxl34 134 19 test test VB cord-303447-3a7jxl34 134 20 all all DT cord-303447-3a7jxl34 134 21 women woman NNS cord-303447-3a7jxl34 134 22 for for IN cord-303447-3a7jxl34 134 23 HBsAg hbsag ADD cord-303447-3a7jxl34 134 24 during during IN cord-303447-3a7jxl34 134 25 the the DT cord-303447-3a7jxl34 134 26 prenatal prenatal JJ cord-303447-3a7jxl34 134 27 period period NN cord-303447-3a7jxl34 134 28 . . . cord-303447-3a7jxl34 135 1 Vaccinating vaccinate VBG cord-303447-3a7jxl34 135 2 high high JJ cord-303447-3a7jxl34 135 3 - - HYPH cord-303447-3a7jxl34 135 4 risk risk NN cord-303447-3a7jxl34 135 5 groups group NNS cord-303447-3a7jxl34 135 6 continued continue VBD cord-303447-3a7jxl34 135 7 to to TO cord-303447-3a7jxl34 135 8 be be VB cord-303447-3a7jxl34 135 9 difficult difficult JJ cord-303447-3a7jxl34 135 10 because because IN cord-303447-3a7jxl34 135 11 no no DT cord-303447-3a7jxl34 135 12 foundation foundation NN cord-303447-3a7jxl34 135 13 existed exist VBD cord-303447-3a7jxl34 135 14 to to TO cord-303447-3a7jxl34 135 15 vaccinate vaccinate VB cord-303447-3a7jxl34 135 16 adolescents adolescent NNS cord-303447-3a7jxl34 135 17 and and CC cord-303447-3a7jxl34 135 18 adults adult NNS cord-303447-3a7jxl34 135 19 who who WP cord-303447-3a7jxl34 135 20 already already RB cord-303447-3a7jxl34 135 21 were be VBD cord-303447-3a7jxl34 135 22 participating participate VBG cord-303447-3a7jxl34 135 23 in in IN cord-303447-3a7jxl34 135 24 high high JJ cord-303447-3a7jxl34 135 25 - - HYPH cord-303447-3a7jxl34 135 26 risk risk NN cord-303447-3a7jxl34 135 27 activities activity NNS cord-303447-3a7jxl34 135 28 . . . cord-303447-3a7jxl34 136 1 In in IN cord-303447-3a7jxl34 136 2 1991 1991 CD cord-303447-3a7jxl34 136 3 , , , cord-303447-3a7jxl34 136 4 a a DT cord-303447-3a7jxl34 136 5 universal universal JJ cord-303447-3a7jxl34 136 6 infant infant NN cord-303447-3a7jxl34 136 7 vaccination vaccination NN cord-303447-3a7jxl34 136 8 strategy strategy NN cord-303447-3a7jxl34 136 9 was be VBD cord-303447-3a7jxl34 136 10 instituted institute VBN cord-303447-3a7jxl34 136 11 to to TO cord-303447-3a7jxl34 136 12 achieve achieve VB cord-303447-3a7jxl34 136 13 the the DT cord-303447-3a7jxl34 136 14 goal goal NN cord-303447-3a7jxl34 136 15 of of IN cord-303447-3a7jxl34 136 16 reducing reduce VBG cord-303447-3a7jxl34 136 17 transmission transmission NN cord-303447-3a7jxl34 136 18 of of IN cord-303447-3a7jxl34 136 19 hepatitis hepatitis NN cord-303447-3a7jxl34 136 20 B B NNP cord-303447-3a7jxl34 136 21 virus virus NN cord-303447-3a7jxl34 136 22 [ [ -LRB- cord-303447-3a7jxl34 136 23 46 46 CD cord-303447-3a7jxl34 136 24 ] ] -RRB- cord-303447-3a7jxl34 136 25 . . . cord-303447-3a7jxl34 137 1 It -PRON- PRP cord-303447-3a7jxl34 137 2 is be VBZ cord-303447-3a7jxl34 137 3 recommended recommend VBN cord-303447-3a7jxl34 137 4 that that IN cord-303447-3a7jxl34 137 5 the the DT cord-303447-3a7jxl34 137 6 first first JJ cord-303447-3a7jxl34 137 7 dose dose NN cord-303447-3a7jxl34 137 8 be be VB cord-303447-3a7jxl34 137 9 given give VBN cord-303447-3a7jxl34 137 10 at at IN cord-303447-3a7jxl34 137 11 or or CC cord-303447-3a7jxl34 137 12 before before IN cord-303447-3a7jxl34 137 13 2 2 CD cord-303447-3a7jxl34 137 14 months month NNS cord-303447-3a7jxl34 137 15 of of IN cord-303447-3a7jxl34 137 16 age age NN cord-303447-3a7jxl34 137 17 with with IN cord-303447-3a7jxl34 137 18 a a DT cord-303447-3a7jxl34 137 19 preference preference NN cord-303447-3a7jxl34 137 20 for for IN cord-303447-3a7jxl34 137 21 all all DT cord-303447-3a7jxl34 137 22 infants infant NNS cord-303447-3a7jxl34 137 23 to to TO cord-303447-3a7jxl34 137 24 receive receive VB cord-303447-3a7jxl34 137 25 the the DT cord-303447-3a7jxl34 137 26 first first JJ cord-303447-3a7jxl34 137 27 dose dose NN cord-303447-3a7jxl34 137 28 at at IN cord-303447-3a7jxl34 137 29 birth birth NN cord-303447-3a7jxl34 137 30 . . . cord-303447-3a7jxl34 138 1 Neonatal neonatal JJ cord-303447-3a7jxl34 138 2 vaccination vaccination NN cord-303447-3a7jxl34 138 3 works work VBZ cord-303447-3a7jxl34 138 4 by by IN cord-303447-3a7jxl34 138 5 protecting protect VBG cord-303447-3a7jxl34 138 6 the the DT cord-303447-3a7jxl34 138 7 infant infant NN cord-303447-3a7jxl34 138 8 from from IN cord-303447-3a7jxl34 138 9 contracting contract VBG cord-303447-3a7jxl34 138 10 hepatitis hepatitis NN cord-303447-3a7jxl34 138 11 after after IN cord-303447-3a7jxl34 138 12 vertical vertical JJ cord-303447-3a7jxl34 138 13 or or CC cord-303447-3a7jxl34 138 14 horizontal horizontal JJ cord-303447-3a7jxl34 138 15 exposure exposure NN cord-303447-3a7jxl34 138 16 . . . cord-303447-3a7jxl34 139 1 Giving give VBG cord-303447-3a7jxl34 139 2 all all DT cord-303447-3a7jxl34 139 3 infants infant NNS cord-303447-3a7jxl34 139 4 the the DT cord-303447-3a7jxl34 139 5 birth birth NN cord-303447-3a7jxl34 139 6 dose dose NN cord-303447-3a7jxl34 139 7 protects protect VBZ cord-303447-3a7jxl34 139 8 infants infant NNS cord-303447-3a7jxl34 139 9 whose whose WP$ cord-303447-3a7jxl34 139 10 mothers mother NNS cord-303447-3a7jxl34 139 11 were be VBD cord-303447-3a7jxl34 139 12 not not RB cord-303447-3a7jxl34 139 13 tested test VBN cord-303447-3a7jxl34 139 14 for for IN cord-303447-3a7jxl34 139 15 HBsAg hbsag ADD cord-303447-3a7jxl34 139 16 during during IN cord-303447-3a7jxl34 139 17 pregnancy pregnancy NN cord-303447-3a7jxl34 139 18 . . . cord-303447-3a7jxl34 140 1 Infant infant NN cord-303447-3a7jxl34 140 2 vaccination vaccination NN cord-303447-3a7jxl34 140 3 eventually eventually RB cord-303447-3a7jxl34 140 4 will will MD cord-303447-3a7jxl34 140 5 provide provide VB cord-303447-3a7jxl34 140 6 protection protection NN cord-303447-3a7jxl34 140 7 against against IN cord-303447-3a7jxl34 140 8 hepatitis hepatitis NN cord-303447-3a7jxl34 140 9 B B NNP cord-303447-3a7jxl34 140 10 virus virus NN cord-303447-3a7jxl34 140 11 to to IN cord-303447-3a7jxl34 140 12 adolescents adolescent NNS cord-303447-3a7jxl34 140 13 who who WP cord-303447-3a7jxl34 140 14 may may MD cord-303447-3a7jxl34 140 15 engage engage VB cord-303447-3a7jxl34 140 16 in in IN cord-303447-3a7jxl34 140 17 high high JJ cord-303447-3a7jxl34 140 18 - - HYPH cord-303447-3a7jxl34 140 19 risk risk NN cord-303447-3a7jxl34 140 20 activities activity NNS cord-303447-3a7jxl34 140 21 before before IN cord-303447-3a7jxl34 140 22 exposure exposure NN cord-303447-3a7jxl34 140 23 . . . cord-303447-3a7jxl34 141 1 From from IN cord-303447-3a7jxl34 141 2 1990 1990 CD cord-303447-3a7jxl34 141 3 to to IN cord-303447-3a7jxl34 141 4 2002 2002 CD cord-303447-3a7jxl34 141 5 , , , cord-303447-3a7jxl34 141 6 rates rate NNS cord-303447-3a7jxl34 141 7 of of IN cord-303447-3a7jxl34 141 8 hepatitis hepatitis NN cord-303447-3a7jxl34 141 9 B B NNP cord-303447-3a7jxl34 141 10 virus virus NN cord-303447-3a7jxl34 141 11 infection infection NN cord-303447-3a7jxl34 141 12 in in IN cord-303447-3a7jxl34 141 13 children child NNS cord-303447-3a7jxl34 141 14 and and CC cord-303447-3a7jxl34 141 15 adolescents adolescent NNS cord-303447-3a7jxl34 141 16 younger young JJR cord-303447-3a7jxl34 141 17 than than IN cord-303447-3a7jxl34 141 18 20 20 CD cord-303447-3a7jxl34 141 19 years year NNS cord-303447-3a7jxl34 141 20 old old JJ cord-303447-3a7jxl34 141 21 declined decline VBD cord-303447-3a7jxl34 141 22 more more JJR cord-303447-3a7jxl34 141 23 than than IN cord-303447-3a7jxl34 141 24 88 88 CD cord-303447-3a7jxl34 141 25 % % NN cord-303447-3a7jxl34 141 26 in in IN cord-303447-3a7jxl34 141 27 the the DT cord-303447-3a7jxl34 141 28 United United NNP cord-303447-3a7jxl34 141 29 States States NNP cord-303447-3a7jxl34 141 30 [ [ -LRB- cord-303447-3a7jxl34 141 31 47 47 CD cord-303447-3a7jxl34 141 32 ] ] -RRB- cord-303447-3a7jxl34 141 33 . . . cord-303447-3a7jxl34 142 1 From from IN cord-303447-3a7jxl34 142 2 2000 2000 CD cord-303447-3a7jxl34 142 3 to to IN cord-303447-3a7jxl34 142 4 2002 2002 CD cord-303447-3a7jxl34 142 5 , , , cord-303447-3a7jxl34 142 6 approximately approximately RB cord-303447-3a7jxl34 142 7 2400 2400 CD cord-303447-3a7jxl34 142 8 to to IN cord-303447-3a7jxl34 142 9 3000 3000 CD cord-303447-3a7jxl34 142 10 cases case NNS cord-303447-3a7jxl34 142 11 of of IN cord-303447-3a7jxl34 142 12 invasive invasive JJ cord-303447-3a7jxl34 142 13 meningococcal meningococcal JJ cord-303447-3a7jxl34 142 14 disease disease NN cord-303447-3a7jxl34 142 15 occurred occur VBD cord-303447-3a7jxl34 142 16 annually annually RB cord-303447-3a7jxl34 142 17 in in IN cord-303447-3a7jxl34 142 18 the the DT cord-303447-3a7jxl34 142 19 United United NNP cord-303447-3a7jxl34 142 20 States States NNP cord-303447-3a7jxl34 142 21 [ [ -LRB- cord-303447-3a7jxl34 142 22 48 48 CD cord-303447-3a7jxl34 142 23 ] ] -RRB- cord-303447-3a7jxl34 142 24 . . . cord-303447-3a7jxl34 143 1 The the DT cord-303447-3a7jxl34 143 2 case case NN cord-303447-3a7jxl34 143 3 - - HYPH cord-303447-3a7jxl34 143 4 fatality fatality NN cord-303447-3a7jxl34 143 5 ratio ratio NN cord-303447-3a7jxl34 143 6 for for IN cord-303447-3a7jxl34 143 7 meningococcal meningococcal JJ cord-303447-3a7jxl34 143 8 disease disease NN cord-303447-3a7jxl34 143 9 is be VBZ cord-303447-3a7jxl34 143 10 approximately approximately RB cord-303447-3a7jxl34 143 11 10 10 CD cord-303447-3a7jxl34 143 12 % % NN cord-303447-3a7jxl34 143 13 , , , cord-303447-3a7jxl34 143 14 and and CC cord-303447-3a7jxl34 143 15 severe severe JJ cord-303447-3a7jxl34 143 16 sequelae sequela NNS cord-303447-3a7jxl34 143 17 ( ( -LRB- cord-303447-3a7jxl34 143 18 eg eg IN cord-303447-3a7jxl34 143 19 , , , cord-303447-3a7jxl34 143 20 neurologic neurologic JJ cord-303447-3a7jxl34 143 21 disability disability NN cord-303447-3a7jxl34 143 22 , , , cord-303447-3a7jxl34 143 23 limb limb NN cord-303447-3a7jxl34 143 24 loss loss NN cord-303447-3a7jxl34 143 25 ) ) -RRB- cord-303447-3a7jxl34 143 26 occur occur VBP cord-303447-3a7jxl34 143 27 in in IN cord-303447-3a7jxl34 143 28 approximately approximately RB cord-303447-3a7jxl34 143 29 10 10 CD cord-303447-3a7jxl34 143 30 % % NN cord-303447-3a7jxl34 143 31 of of IN cord-303447-3a7jxl34 143 32 survivors survivor NNS cord-303447-3a7jxl34 143 33 [ [ -LRB- cord-303447-3a7jxl34 143 34 49 49 CD cord-303447-3a7jxl34 143 35 ] ] -RRB- cord-303447-3a7jxl34 143 36 . . . cord-303447-3a7jxl34 144 1 Nasopharyngeal nasopharyngeal JJ cord-303447-3a7jxl34 144 2 carriage carriage NN cord-303447-3a7jxl34 144 3 of of IN cord-303447-3a7jxl34 144 4 Neisseria Neisseria NNP cord-303447-3a7jxl34 144 5 meningitidis meningitidis NN cord-303447-3a7jxl34 144 6 occurs occur VBZ cord-303447-3a7jxl34 144 7 in in IN cord-303447-3a7jxl34 144 8 approximately approximately RB cord-303447-3a7jxl34 144 9 5 5 CD cord-303447-3a7jxl34 144 10 % % NN cord-303447-3a7jxl34 144 11 to to TO cord-303447-3a7jxl34 144 12 10 10 CD cord-303447-3a7jxl34 144 13 % % NN cord-303447-3a7jxl34 144 14 of of IN cord-303447-3a7jxl34 144 15 the the DT cord-303447-3a7jxl34 144 16 US US NNP cord-303447-3a7jxl34 144 17 population population NN cord-303447-3a7jxl34 144 18 [ [ -LRB- cord-303447-3a7jxl34 144 19 48 48 CD cord-303447-3a7jxl34 144 20 ] ] -RRB- cord-303447-3a7jxl34 144 21 . . . cord-303447-3a7jxl34 145 1 Transmission transmission NN cord-303447-3a7jxl34 145 2 is be VBZ cord-303447-3a7jxl34 145 3 through through IN cord-303447-3a7jxl34 145 4 direct direct JJ cord-303447-3a7jxl34 145 5 contact contact NN cord-303447-3a7jxl34 145 6 with with IN cord-303447-3a7jxl34 145 7 respiratory respiratory JJ cord-303447-3a7jxl34 145 8 tract tract NN cord-303447-3a7jxl34 145 9 droplets droplet NNS cord-303447-3a7jxl34 145 10 of of IN cord-303447-3a7jxl34 145 11 infected infected JJ cord-303447-3a7jxl34 145 12 individuals individual NNS cord-303447-3a7jxl34 145 13 . . . cord-303447-3a7jxl34 146 1 Infants infant NNS cord-303447-3a7jxl34 146 2 younger young JJR cord-303447-3a7jxl34 146 3 than than IN cord-303447-3a7jxl34 146 4 1 1 CD cord-303447-3a7jxl34 146 5 year year NN cord-303447-3a7jxl34 146 6 of of IN cord-303447-3a7jxl34 146 7 age age NN cord-303447-3a7jxl34 146 8 have have VBP cord-303447-3a7jxl34 146 9 the the DT cord-303447-3a7jxl34 146 10 highest high JJS cord-303447-3a7jxl34 146 11 rates rate NNS cord-303447-3a7jxl34 146 12 of of IN cord-303447-3a7jxl34 146 13 meningococcal meningococcal JJ cord-303447-3a7jxl34 146 14 disease disease NN cord-303447-3a7jxl34 146 15 , , , cord-303447-3a7jxl34 146 16 with with IN cord-303447-3a7jxl34 146 17 an an DT cord-303447-3a7jxl34 146 18 annual annual JJ cord-303447-3a7jxl34 146 19 incidence incidence NN cord-303447-3a7jxl34 146 20 of of IN cord-303447-3a7jxl34 146 21 6.5 6.5 CD cord-303447-3a7jxl34 146 22 cases case NNS cord-303447-3a7jxl34 146 23 per per IN cord-303447-3a7jxl34 146 24 100,000 100,000 CD cord-303447-3a7jxl34 146 25 population population NN cord-303447-3a7jxl34 146 26 during during IN cord-303447-3a7jxl34 146 27 2002 2002 CD cord-303447-3a7jxl34 146 28 [ [ -LRB- cord-303447-3a7jxl34 146 29 50 50 CD cord-303447-3a7jxl34 146 30 ] ] -RRB- cord-303447-3a7jxl34 146 31 . . . cord-303447-3a7jxl34 147 1 During during IN cord-303447-3a7jxl34 147 2 the the DT cord-303447-3a7jxl34 147 3 1990s 1990 NNS cord-303447-3a7jxl34 147 4 , , , cord-303447-3a7jxl34 147 5 incidence incidence NN cord-303447-3a7jxl34 147 6 rates rate NNS cord-303447-3a7jxl34 147 7 of of IN cord-303447-3a7jxl34 147 8 meningococcal meningococcal JJ cord-303447-3a7jxl34 147 9 disease disease NN cord-303447-3a7jxl34 147 10 increased increase VBD cord-303447-3a7jxl34 147 11 among among IN cord-303447-3a7jxl34 147 12 adolescents adolescent NNS cord-303447-3a7jxl34 147 13 and and CC cord-303447-3a7jxl34 147 14 young young JJ cord-303447-3a7jxl34 147 15 adults adult NNS cord-303447-3a7jxl34 147 16 [ [ -LRB- cord-303447-3a7jxl34 147 17 49 49 CD cord-303447-3a7jxl34 147 18 ] ] -RRB- cord-303447-3a7jxl34 147 19 . . . cord-303447-3a7jxl34 148 1 Evidence evidence NN cord-303447-3a7jxl34 148 2 also also RB cord-303447-3a7jxl34 148 3 showed show VBD cord-303447-3a7jxl34 148 4 that that IN cord-303447-3a7jxl34 148 5 college college NN cord-303447-3a7jxl34 148 6 freshmen freshman NNS cord-303447-3a7jxl34 148 7 living live VBG cord-303447-3a7jxl34 148 8 in in IN cord-303447-3a7jxl34 148 9 dormitories dormitory NNS cord-303447-3a7jxl34 148 10 have have VBP cord-303447-3a7jxl34 148 11 a a DT cord-303447-3a7jxl34 148 12 modestly modestly RB cord-303447-3a7jxl34 148 13 increased increase VBN cord-303447-3a7jxl34 148 14 risk risk NN cord-303447-3a7jxl34 148 15 of of IN cord-303447-3a7jxl34 148 16 meningococcal meningococcal JJ cord-303447-3a7jxl34 148 17 disease disease NN cord-303447-3a7jxl34 148 18 ( ( -LRB- cord-303447-3a7jxl34 148 19 4.6 4.6 CD cord-303447-3a7jxl34 148 20 cases case NNS cord-303447-3a7jxl34 148 21 per per IN cord-303447-3a7jxl34 148 22 100,000 100,000 CD cord-303447-3a7jxl34 148 23 ) ) -RRB- cord-303447-3a7jxl34 148 24 compared compare VBN cord-303447-3a7jxl34 148 25 with with IN cord-303447-3a7jxl34 148 26 other other JJ cord-303447-3a7jxl34 148 27 persons person NNS cord-303447-3a7jxl34 148 28 the the DT cord-303447-3a7jxl34 148 29 same same JJ cord-303447-3a7jxl34 148 30 age age NN cord-303447-3a7jxl34 148 31 [ [ -LRB- cord-303447-3a7jxl34 148 32 49 49 CD cord-303447-3a7jxl34 148 33 ] ] -RRB- cord-303447-3a7jxl34 148 34 . . . cord-303447-3a7jxl34 149 1 A a DT cord-303447-3a7jxl34 149 2 meningococcal meningococcal JJ cord-303447-3a7jxl34 149 3 polysaccharide polysaccharide NN cord-303447-3a7jxl34 149 4 ( ( -LRB- cord-303447-3a7jxl34 149 5 MPS MPS NNP cord-303447-3a7jxl34 149 6 ) ) -RRB- cord-303447-3a7jxl34 149 7 vaccine vaccine NN cord-303447-3a7jxl34 149 8 containing contain VBG cord-303447-3a7jxl34 149 9 the the DT cord-303447-3a7jxl34 149 10 antigens antigen NNS cord-303447-3a7jxl34 149 11 of of IN cord-303447-3a7jxl34 149 12 serogroups serogroup NNS cord-303447-3a7jxl34 149 13 A A NNP cord-303447-3a7jxl34 149 14 , , , cord-303447-3a7jxl34 149 15 C C NNP cord-303447-3a7jxl34 149 16 , , , cord-303447-3a7jxl34 149 17 Y Y NNP cord-303447-3a7jxl34 149 18 , , , cord-303447-3a7jxl34 149 19 and and CC cord-303447-3a7jxl34 149 20 W135 W135 NNPS cord-303447-3a7jxl34 149 21 has have VBZ cord-303447-3a7jxl34 149 22 been be VBN cord-303447-3a7jxl34 149 23 used use VBN cord-303447-3a7jxl34 149 24 in in IN cord-303447-3a7jxl34 149 25 the the DT cord-303447-3a7jxl34 149 26 United United NNP cord-303447-3a7jxl34 149 27 States States NNP cord-303447-3a7jxl34 149 28 since since IN cord-303447-3a7jxl34 149 29 licensure licensure NN cord-303447-3a7jxl34 149 30 in in IN cord-303447-3a7jxl34 149 31 1981 1981 CD cord-303447-3a7jxl34 149 32 . . . cord-303447-3a7jxl34 150 1 This this DT cord-303447-3a7jxl34 150 2 vaccine vaccine NN cord-303447-3a7jxl34 150 3 protects protect VBZ cord-303447-3a7jxl34 150 4 against against IN cord-303447-3a7jxl34 150 5 the the DT cord-303447-3a7jxl34 150 6 serogroups serogroup NNS cord-303447-3a7jxl34 150 7 that that WDT cord-303447-3a7jxl34 150 8 cause cause VBP cord-303447-3a7jxl34 150 9 approximately approximately RB cord-303447-3a7jxl34 150 10 two two CD cord-303447-3a7jxl34 150 11 thirds third NNS cord-303447-3a7jxl34 150 12 of of IN cord-303447-3a7jxl34 150 13 meningococcal meningococcal JJ cord-303447-3a7jxl34 150 14 disease disease NN cord-303447-3a7jxl34 150 15 that that WDT cord-303447-3a7jxl34 150 16 occurs occur VBZ cord-303447-3a7jxl34 150 17 in in IN cord-303447-3a7jxl34 150 18 persons person NNS cord-303447-3a7jxl34 150 19 18 18 CD cord-303447-3a7jxl34 150 20 to to TO cord-303447-3a7jxl34 150 21 23 23 CD cord-303447-3a7jxl34 150 22 years year NNS cord-303447-3a7jxl34 150 23 old old JJ cord-303447-3a7jxl34 150 24 in in IN cord-303447-3a7jxl34 150 25 the the DT cord-303447-3a7jxl34 150 26 United United NNP cord-303447-3a7jxl34 150 27 States States NNP cord-303447-3a7jxl34 150 28 . . . cord-303447-3a7jxl34 151 1 More More JJR cord-303447-3a7jxl34 151 2 than than IN cord-303447-3a7jxl34 151 3 half half NN cord-303447-3a7jxl34 151 4 of of IN cord-303447-3a7jxl34 151 5 cases case NNS cord-303447-3a7jxl34 151 6 in in IN cord-303447-3a7jxl34 151 7 infants infant NNS cord-303447-3a7jxl34 151 8 are be VBP cord-303447-3a7jxl34 151 9 due due JJ cord-303447-3a7jxl34 151 10 to to TO cord-303447-3a7jxl34 151 11 serogroup serogroup NNP cord-303447-3a7jxl34 151 12 B B NNP cord-303447-3a7jxl34 151 13 , , , cord-303447-3a7jxl34 151 14 however however RB cord-303447-3a7jxl34 151 15 , , , cord-303447-3a7jxl34 151 16 for for IN cord-303447-3a7jxl34 151 17 which which WDT cord-303447-3a7jxl34 151 18 a a DT cord-303447-3a7jxl34 151 19 licensed licensed JJ cord-303447-3a7jxl34 151 20 vaccine vaccine NN cord-303447-3a7jxl34 151 21 does do VBZ cord-303447-3a7jxl34 151 22 not not RB cord-303447-3a7jxl34 151 23 exist exist VB cord-303447-3a7jxl34 151 24 in in IN cord-303447-3a7jxl34 151 25 the the DT cord-303447-3a7jxl34 151 26 United United NNP cord-303447-3a7jxl34 151 27 States States NNP cord-303447-3a7jxl34 151 28 [ [ -LRB- cord-303447-3a7jxl34 151 29 49 49 CD cord-303447-3a7jxl34 151 30 ] ] -RRB- cord-303447-3a7jxl34 151 31 . . . cord-303447-3a7jxl34 152 1 Similar similar JJ cord-303447-3a7jxl34 152 2 to to IN cord-303447-3a7jxl34 152 3 other other JJ cord-303447-3a7jxl34 152 4 polysaccharide polysaccharide NN cord-303447-3a7jxl34 152 5 vaccines vaccine NNS cord-303447-3a7jxl34 152 6 , , , cord-303447-3a7jxl34 152 7 MPS MPS NNP cord-303447-3a7jxl34 152 8 induces induce VBZ cord-303447-3a7jxl34 152 9 a a DT cord-303447-3a7jxl34 152 10 T T NNP cord-303447-3a7jxl34 152 11 cell cell NN cord-303447-3a7jxl34 152 12 - - HYPH cord-303447-3a7jxl34 152 13 independent independent JJ cord-303447-3a7jxl34 152 14 immune immune JJ cord-303447-3a7jxl34 152 15 response response NN cord-303447-3a7jxl34 152 16 resulting result VBG cord-303447-3a7jxl34 152 17 in in IN cord-303447-3a7jxl34 152 18 poor poor JJ cord-303447-3a7jxl34 152 19 long long JJ cord-303447-3a7jxl34 152 20 - - HYPH cord-303447-3a7jxl34 152 21 term term NN cord-303447-3a7jxl34 152 22 immunity immunity NN cord-303447-3a7jxl34 152 23 and and CC cord-303447-3a7jxl34 152 24 inconsistent inconsistent JJ cord-303447-3a7jxl34 152 25 immunogenicity immunogenicity NN cord-303447-3a7jxl34 152 26 in in IN cord-303447-3a7jxl34 152 27 children child NNS cord-303447-3a7jxl34 152 28 younger young JJR cord-303447-3a7jxl34 152 29 than than IN cord-303447-3a7jxl34 152 30 2 2 CD cord-303447-3a7jxl34 152 31 years year NNS cord-303447-3a7jxl34 152 32 old old JJ cord-303447-3a7jxl34 152 33 . . . cord-303447-3a7jxl34 153 1 An an DT cord-303447-3a7jxl34 153 2 additional additional JJ cord-303447-3a7jxl34 153 3 shortcoming shortcoming NN cord-303447-3a7jxl34 153 4 is be VBZ cord-303447-3a7jxl34 153 5 that that IN cord-303447-3a7jxl34 153 6 MPS MPS NNP cord-303447-3a7jxl34 153 7 does do VBZ cord-303447-3a7jxl34 153 8 not not RB cord-303447-3a7jxl34 153 9 reduce reduce VB cord-303447-3a7jxl34 153 10 nasopharyngeal nasopharyngeal JJ cord-303447-3a7jxl34 153 11 carriage carriage NN cord-303447-3a7jxl34 153 12 or or CC cord-303447-3a7jxl34 153 13 induce induce VB cord-303447-3a7jxl34 153 14 herd herd NN cord-303447-3a7jxl34 153 15 immunity immunity NN cord-303447-3a7jxl34 153 16 [ [ -LRB- cord-303447-3a7jxl34 153 17 48 48 CD cord-303447-3a7jxl34 153 18 ] ] -RRB- cord-303447-3a7jxl34 153 19 . . . cord-303447-3a7jxl34 154 1 Before before IN cord-303447-3a7jxl34 154 2 February February NNP cord-303447-3a7jxl34 154 3 2005 2005 CD cord-303447-3a7jxl34 154 4 , , , cord-303447-3a7jxl34 154 5 MPS MPS NNP cord-303447-3a7jxl34 154 6 vaccine vaccine NN cord-303447-3a7jxl34 154 7 was be VBD cord-303447-3a7jxl34 154 8 recommended recommend VBN cord-303447-3a7jxl34 154 9 for for IN cord-303447-3a7jxl34 154 10 groups group NNS cord-303447-3a7jxl34 154 11 at at IN cord-303447-3a7jxl34 154 12 high high JJ cord-303447-3a7jxl34 154 13 risk risk NN cord-303447-3a7jxl34 154 14 for for IN cord-303447-3a7jxl34 154 15 meningococcal meningococcal JJ cord-303447-3a7jxl34 154 16 disease disease NN cord-303447-3a7jxl34 154 17 and and CC cord-303447-3a7jxl34 154 18 for for IN cord-303447-3a7jxl34 154 19 outbreak outbreak NN cord-303447-3a7jxl34 154 20 control control NN cord-303447-3a7jxl34 154 21 . . . cord-303447-3a7jxl34 155 1 Educating educate VBG cord-303447-3a7jxl34 155 2 college college NN cord-303447-3a7jxl34 155 3 freshmen freshman NNS cord-303447-3a7jxl34 155 4 about about IN cord-303447-3a7jxl34 155 5 the the DT cord-303447-3a7jxl34 155 6 potential potential NN cord-303447-3a7jxl34 155 7 for for IN cord-303447-3a7jxl34 155 8 the the DT cord-303447-3a7jxl34 155 9 MPS MPS NNP cord-303447-3a7jxl34 155 10 vaccine vaccine NN cord-303447-3a7jxl34 155 11 to to TO cord-303447-3a7jxl34 155 12 prevent prevent VB cord-303447-3a7jxl34 155 13 severe severe JJ cord-303447-3a7jxl34 155 14 infection infection NN cord-303447-3a7jxl34 155 15 also also RB cord-303447-3a7jxl34 155 16 was be VBD cord-303447-3a7jxl34 155 17 recommended recommend VBN cord-303447-3a7jxl34 155 18 . . . cord-303447-3a7jxl34 156 1 Some some DT cord-303447-3a7jxl34 156 2 states state NNS cord-303447-3a7jxl34 156 3 required require VBD cord-303447-3a7jxl34 156 4 proof proof NN cord-303447-3a7jxl34 156 5 of of IN cord-303447-3a7jxl34 156 6 vaccination vaccination NN cord-303447-3a7jxl34 156 7 or or CC cord-303447-3a7jxl34 156 8 vaccine vaccine NN cord-303447-3a7jxl34 156 9 waiver waiver NN cord-303447-3a7jxl34 156 10 for for IN cord-303447-3a7jxl34 156 11 entry entry NN cord-303447-3a7jxl34 156 12 into into IN cord-303447-3a7jxl34 156 13 colleges college NNS cord-303447-3a7jxl34 156 14 and and CC cord-303447-3a7jxl34 156 15 universities university NNS cord-303447-3a7jxl34 156 16 [ [ -LRB- cord-303447-3a7jxl34 156 17 49 49 CD cord-303447-3a7jxl34 156 18 ] ] -RRB- cord-303447-3a7jxl34 156 19 . . . cord-303447-3a7jxl34 157 1 Employing employ VBG cord-303447-3a7jxl34 157 2 the the DT cord-303447-3a7jxl34 157 3 same same JJ cord-303447-3a7jxl34 157 4 technology technology NN cord-303447-3a7jxl34 157 5 used use VBN cord-303447-3a7jxl34 157 6 to to TO cord-303447-3a7jxl34 157 7 develop develop VB cord-303447-3a7jxl34 157 8 PCV7 PCV7 NNP cord-303447-3a7jxl34 157 9 , , , cord-303447-3a7jxl34 157 10 a a DT cord-303447-3a7jxl34 157 11 meningococcal meningococcal JJ cord-303447-3a7jxl34 157 12 serogroup serogroup NN cord-303447-3a7jxl34 157 13 C C NNP cord-303447-3a7jxl34 157 14 conjugate conjugate NN cord-303447-3a7jxl34 157 15 vaccine vaccine NN cord-303447-3a7jxl34 157 16 was be VBD cord-303447-3a7jxl34 157 17 licensed license VBN cord-303447-3a7jxl34 157 18 in in IN cord-303447-3a7jxl34 157 19 the the DT cord-303447-3a7jxl34 157 20 United United NNP cord-303447-3a7jxl34 157 21 Kingdom Kingdom NNP cord-303447-3a7jxl34 157 22 in in IN cord-303447-3a7jxl34 157 23 1999 1999 CD cord-303447-3a7jxl34 157 24 . . . cord-303447-3a7jxl34 158 1 The the DT cord-303447-3a7jxl34 158 2 vaccine vaccine NN cord-303447-3a7jxl34 158 3 was be VBD cord-303447-3a7jxl34 158 4 introduced introduce VBN cord-303447-3a7jxl34 158 5 into into IN cord-303447-3a7jxl34 158 6 the the DT cord-303447-3a7jxl34 158 7 routine routine JJ cord-303447-3a7jxl34 158 8 infant infant NN cord-303447-3a7jxl34 158 9 schedule schedule NN cord-303447-3a7jxl34 158 10 , , , cord-303447-3a7jxl34 158 11 with with IN cord-303447-3a7jxl34 158 12 catch catch VB cord-303447-3a7jxl34 158 13 - - HYPH cord-303447-3a7jxl34 158 14 up up RP cord-303447-3a7jxl34 158 15 vaccination vaccination NN cord-303447-3a7jxl34 158 16 for for IN cord-303447-3a7jxl34 158 17 older old JJR cord-303447-3a7jxl34 158 18 children child NNS cord-303447-3a7jxl34 158 19 and and CC cord-303447-3a7jxl34 158 20 adolescents adolescent NNS cord-303447-3a7jxl34 158 21 . . . cord-303447-3a7jxl34 159 1 In in IN cord-303447-3a7jxl34 159 2 the the DT cord-303447-3a7jxl34 159 3 2 2 CD cord-303447-3a7jxl34 159 4 years year NNS cord-303447-3a7jxl34 159 5 after after IN cord-303447-3a7jxl34 159 6 introduction introduction NN cord-303447-3a7jxl34 159 7 of of IN cord-303447-3a7jxl34 159 8 infant infant NN cord-303447-3a7jxl34 159 9 meningococcal meningococcal JJ cord-303447-3a7jxl34 159 10 conjugate conjugate NN cord-303447-3a7jxl34 159 11 vaccine vaccine NN cord-303447-3a7jxl34 159 12 , , , cord-303447-3a7jxl34 159 13 the the DT cord-303447-3a7jxl34 159 14 incidence incidence NN cord-303447-3a7jxl34 159 15 of of IN cord-303447-3a7jxl34 159 16 serogroup serogroup NNP cord-303447-3a7jxl34 159 17 C C NNP cord-303447-3a7jxl34 159 18 meningococcal meningococcal NNP cord-303447-3a7jxl34 159 19 disease disease NN cord-303447-3a7jxl34 159 20 declined decline VBD cord-303447-3a7jxl34 159 21 by by IN cord-303447-3a7jxl34 159 22 87 87 CD cord-303447-3a7jxl34 159 23 % % NN cord-303447-3a7jxl34 159 24 in in IN cord-303447-3a7jxl34 159 25 vaccinated vaccinated JJ cord-303447-3a7jxl34 159 26 persons person NNS cord-303447-3a7jxl34 159 27 and and CC cord-303447-3a7jxl34 159 28 at at RB cord-303447-3a7jxl34 159 29 least least RBS cord-303447-3a7jxl34 159 30 34 34 CD cord-303447-3a7jxl34 159 31 % % NN cord-303447-3a7jxl34 159 32 in in IN cord-303447-3a7jxl34 159 33 unvaccinated unvaccinated JJ cord-303447-3a7jxl34 159 34 persons person NNS cord-303447-3a7jxl34 159 35 , , , cord-303447-3a7jxl34 159 36 suggesting suggest VBG cord-303447-3a7jxl34 159 37 the the DT cord-303447-3a7jxl34 159 38 vaccine vaccine NN cord-303447-3a7jxl34 159 39 produced produce VBD cord-303447-3a7jxl34 159 40 herd herd NN cord-303447-3a7jxl34 159 41 immunity immunity NN cord-303447-3a7jxl34 159 42 [ [ -LRB- cord-303447-3a7jxl34 159 43 48 48 CD cord-303447-3a7jxl34 159 44 ] ] -RRB- cord-303447-3a7jxl34 159 45 . . . cord-303447-3a7jxl34 160 1 In in IN cord-303447-3a7jxl34 160 2 the the DT cord-303447-3a7jxl34 160 3 United United NNP cord-303447-3a7jxl34 160 4 States States NNP cord-303447-3a7jxl34 160 5 , , , cord-303447-3a7jxl34 160 6 a a DT cord-303447-3a7jxl34 160 7 quadrivalet quadrivalet NN cord-303447-3a7jxl34 160 8 meningococcal meningococcal JJ cord-303447-3a7jxl34 160 9 conjugate conjugate NN cord-303447-3a7jxl34 160 10 vaccine vaccine NN cord-303447-3a7jxl34 160 11 ( ( -LRB- cord-303447-3a7jxl34 160 12 serogroups serogroup NNS cord-303447-3a7jxl34 160 13 A A NNP cord-303447-3a7jxl34 160 14 , , , cord-303447-3a7jxl34 160 15 C C NNP cord-303447-3a7jxl34 160 16 , , , cord-303447-3a7jxl34 160 17 Y Y NNP cord-303447-3a7jxl34 160 18 , , , cord-303447-3a7jxl34 160 19 and and CC cord-303447-3a7jxl34 160 20 W-135 w-135 NN cord-303447-3a7jxl34 160 21 ) ) -RRB- cord-303447-3a7jxl34 161 1 ( ( -LRB- cord-303447-3a7jxl34 161 2 MCV4 MCV4 NNP cord-303447-3a7jxl34 161 3 ) ) -RRB- cord-303447-3a7jxl34 161 4 was be VBD cord-303447-3a7jxl34 161 5 licensed license VBN cord-303447-3a7jxl34 161 6 on on IN cord-303447-3a7jxl34 161 7 January January NNP cord-303447-3a7jxl34 161 8 14 14 CD cord-303447-3a7jxl34 161 9 , , , cord-303447-3a7jxl34 161 10 2005 2005 CD cord-303447-3a7jxl34 161 11 , , , cord-303447-3a7jxl34 161 12 for for IN cord-303447-3a7jxl34 161 13 use use NN cord-303447-3a7jxl34 161 14 in in IN cord-303447-3a7jxl34 161 15 persons person NNS cord-303447-3a7jxl34 161 16 11 11 CD cord-303447-3a7jxl34 161 17 to to TO cord-303447-3a7jxl34 161 18 55 55 CD cord-303447-3a7jxl34 161 19 years year NNS cord-303447-3a7jxl34 161 20 old old JJ cord-303447-3a7jxl34 161 21 . . . cord-303447-3a7jxl34 162 1 During during IN cord-303447-3a7jxl34 162 2 prelicensure prelicensure JJ cord-303447-3a7jxl34 162 3 clinical clinical JJ cord-303447-3a7jxl34 162 4 trials trial NNS cord-303447-3a7jxl34 162 5 , , , cord-303447-3a7jxl34 162 6 immune immune JJ cord-303447-3a7jxl34 162 7 responses response NNS cord-303447-3a7jxl34 162 8 to to IN cord-303447-3a7jxl34 162 9 MPS MPS NNP cord-303447-3a7jxl34 162 10 and and CC cord-303447-3a7jxl34 162 11 MCV4 MCV4 NNP cord-303447-3a7jxl34 162 12 were be VBD cord-303447-3a7jxl34 162 13 similar similar JJ cord-303447-3a7jxl34 162 14 in in IN cord-303447-3a7jxl34 162 15 adolescents adolescent NNS cord-303447-3a7jxl34 162 16 and and CC cord-303447-3a7jxl34 162 17 adults adult NNS cord-303447-3a7jxl34 162 18 . . . cord-303447-3a7jxl34 163 1 Because because IN cord-303447-3a7jxl34 163 2 MCV4 MCV4 NNP cord-303447-3a7jxl34 163 3 induces induce VBZ cord-303447-3a7jxl34 163 4 T T NNP cord-303447-3a7jxl34 163 5 cell cell NN cord-303447-3a7jxl34 163 6 - - HYPH cord-303447-3a7jxl34 163 7 mediated mediate VBN cord-303447-3a7jxl34 163 8 immunity immunity NN cord-303447-3a7jxl34 163 9 , , , cord-303447-3a7jxl34 163 10 the the DT cord-303447-3a7jxl34 163 11 duration duration NN cord-303447-3a7jxl34 163 12 of of IN cord-303447-3a7jxl34 163 13 protection protection NN cord-303447-3a7jxl34 163 14 is be VBZ cord-303447-3a7jxl34 163 15 thought think VBN cord-303447-3a7jxl34 163 16 to to TO cord-303447-3a7jxl34 163 17 be be VB cord-303447-3a7jxl34 163 18 longer long JJR cord-303447-3a7jxl34 163 19 than than IN cord-303447-3a7jxl34 163 20 immunity immunity NN cord-303447-3a7jxl34 163 21 produced produce VBN cord-303447-3a7jxl34 163 22 by by IN cord-303447-3a7jxl34 163 23 MPS MPS NNP cord-303447-3a7jxl34 163 24 . . . cord-303447-3a7jxl34 164 1 On on IN cord-303447-3a7jxl34 164 2 February February NNP cord-303447-3a7jxl34 164 3 10 10 CD cord-303447-3a7jxl34 164 4 , , , cord-303447-3a7jxl34 164 5 2005 2005 CD cord-303447-3a7jxl34 164 6 , , , cord-303447-3a7jxl34 164 7 the the DT cord-303447-3a7jxl34 164 8 ACIP ACIP NNP cord-303447-3a7jxl34 164 9 voted vote VBD cord-303447-3a7jxl34 164 10 to to TO cord-303447-3a7jxl34 164 11 recommend recommend VB cord-303447-3a7jxl34 164 12 that that IN cord-303447-3a7jxl34 164 13 MCV4 MCV4 NNP cord-303447-3a7jxl34 164 14 be be VB cord-303447-3a7jxl34 164 15 administered administer VBN cord-303447-3a7jxl34 164 16 universally universally RB cord-303447-3a7jxl34 164 17 to to IN cord-303447-3a7jxl34 164 18 adolescents adolescent NNS cord-303447-3a7jxl34 164 19 ages age NNS cord-303447-3a7jxl34 164 20 11 11 CD cord-303447-3a7jxl34 164 21 to to TO cord-303447-3a7jxl34 164 22 12 12 CD cord-303447-3a7jxl34 164 23 and and CC cord-303447-3a7jxl34 164 24 around around RB cord-303447-3a7jxl34 164 25 15 15 CD cord-303447-3a7jxl34 164 26 years year NNS cord-303447-3a7jxl34 164 27 of of IN cord-303447-3a7jxl34 164 28 age age NN cord-303447-3a7jxl34 164 29 , , , cord-303447-3a7jxl34 164 30 and and CC cord-303447-3a7jxl34 164 31 college college NN cord-303447-3a7jxl34 164 32 freshmen freshman NNS cord-303447-3a7jxl34 164 33 living live VBG cord-303447-3a7jxl34 164 34 in in IN cord-303447-3a7jxl34 164 35 dormitories dormitory NNS cord-303447-3a7jxl34 164 36 ; ; : cord-303447-3a7jxl34 164 37 a a DT cord-303447-3a7jxl34 164 38 VFC VFC NNP cord-303447-3a7jxl34 164 39 resolution resolution NN cord-303447-3a7jxl34 164 40 also also RB cord-303447-3a7jxl34 164 41 was be VBD cord-303447-3a7jxl34 164 42 passed pass VBN cord-303447-3a7jxl34 164 43 . . . cord-303447-3a7jxl34 165 1 With with IN cord-303447-3a7jxl34 165 2 the the DT cord-303447-3a7jxl34 165 3 addition addition NN cord-303447-3a7jxl34 165 4 of of IN cord-303447-3a7jxl34 165 5 MCV4 MCV4 NNP cord-303447-3a7jxl34 165 6 to to IN cord-303447-3a7jxl34 165 7 the the DT cord-303447-3a7jxl34 165 8 immunization immunization NN cord-303447-3a7jxl34 165 9 schedule schedule NN cord-303447-3a7jxl34 165 10 , , , cord-303447-3a7jxl34 165 11 a a DT cord-303447-3a7jxl34 165 12 new new JJ cord-303447-3a7jxl34 165 13 era era NN cord-303447-3a7jxl34 165 14 of of IN cord-303447-3a7jxl34 165 15 adolescent adolescent JJ cord-303447-3a7jxl34 165 16 vaccination vaccination NN cord-303447-3a7jxl34 165 17 was be VBD cord-303447-3a7jxl34 165 18 launched launch VBN cord-303447-3a7jxl34 165 19 . . . cord-303447-3a7jxl34 166 1 In in IN cord-303447-3a7jxl34 166 2 the the DT cord-303447-3a7jxl34 166 3 United United NNP cord-303447-3a7jxl34 166 4 States States NNP cord-303447-3a7jxl34 166 5 , , , cord-303447-3a7jxl34 166 6 meningococcal meningococcal JJ cord-303447-3a7jxl34 166 7 conjugate conjugate NN cord-303447-3a7jxl34 166 8 vaccines vaccine NNS cord-303447-3a7jxl34 166 9 for for IN cord-303447-3a7jxl34 166 10 use use NN cord-303447-3a7jxl34 166 11 in in IN cord-303447-3a7jxl34 166 12 children child NNS cord-303447-3a7jxl34 166 13 younger young JJR cord-303447-3a7jxl34 166 14 than than IN cord-303447-3a7jxl34 166 15 11 11 CD cord-303447-3a7jxl34 166 16 years year NNS cord-303447-3a7jxl34 166 17 of of IN cord-303447-3a7jxl34 166 18 age age NN cord-303447-3a7jxl34 166 19 are be VBP cord-303447-3a7jxl34 166 20 under under IN cord-303447-3a7jxl34 166 21 study study NN cord-303447-3a7jxl34 166 22 . . . cord-303447-3a7jxl34 167 1 Pertussis pertussis NN cord-303447-3a7jxl34 167 2 remains remain VBZ cord-303447-3a7jxl34 167 3 endemic endemic JJ cord-303447-3a7jxl34 167 4 in in IN cord-303447-3a7jxl34 167 5 the the DT cord-303447-3a7jxl34 167 6 United United NNP cord-303447-3a7jxl34 167 7 States States NNP cord-303447-3a7jxl34 167 8 despite despite IN cord-303447-3a7jxl34 167 9 high high JJ cord-303447-3a7jxl34 167 10 immunization immunization NN cord-303447-3a7jxl34 167 11 coverage coverage NN cord-303447-3a7jxl34 167 12 rates rate NNS cord-303447-3a7jxl34 167 13 of of IN cord-303447-3a7jxl34 167 14 infants infant NNS cord-303447-3a7jxl34 167 15 and and CC cord-303447-3a7jxl34 167 16 young young JJ cord-303447-3a7jxl34 167 17 children child NNS cord-303447-3a7jxl34 167 18 [ [ -LRB- cord-303447-3a7jxl34 167 19 51 51 CD cord-303447-3a7jxl34 167 20 ] ] -RRB- cord-303447-3a7jxl34 167 21 . . . cord-303447-3a7jxl34 168 1 Immunity immunity NN cord-303447-3a7jxl34 168 2 to to IN cord-303447-3a7jxl34 168 3 pertussis pertussis NN cord-303447-3a7jxl34 168 4 wanes wane VBZ cord-303447-3a7jxl34 168 5 approximately approximately RB cord-303447-3a7jxl34 168 6 5 5 CD cord-303447-3a7jxl34 168 7 to to TO cord-303447-3a7jxl34 168 8 10 10 CD cord-303447-3a7jxl34 168 9 years year NNS cord-303447-3a7jxl34 168 10 after after IN cord-303447-3a7jxl34 168 11 vaccination vaccination NN cord-303447-3a7jxl34 168 12 , , , cord-303447-3a7jxl34 168 13 and and CC cord-303447-3a7jxl34 168 14 loss loss NN cord-303447-3a7jxl34 168 15 of of IN cord-303447-3a7jxl34 168 16 immunity immunity NN cord-303447-3a7jxl34 168 17 seems seem VBZ cord-303447-3a7jxl34 168 18 to to TO cord-303447-3a7jxl34 168 19 play play VB cord-303447-3a7jxl34 168 20 a a DT cord-303447-3a7jxl34 168 21 major major JJ cord-303447-3a7jxl34 168 22 role role NN cord-303447-3a7jxl34 168 23 in in IN cord-303447-3a7jxl34 168 24 the the DT cord-303447-3a7jxl34 168 25 continued continued JJ cord-303447-3a7jxl34 168 26 circulation circulation NN cord-303447-3a7jxl34 168 27 of of IN cord-303447-3a7jxl34 168 28 pertussis pertussis NN cord-303447-3a7jxl34 168 29 [ [ -LRB- cord-303447-3a7jxl34 168 30 52 52 CD cord-303447-3a7jxl34 168 31 ] ] -RRB- cord-303447-3a7jxl34 168 32 . . . cord-303447-3a7jxl34 169 1 In in IN cord-303447-3a7jxl34 169 2 2003 2003 CD cord-303447-3a7jxl34 169 3 and and CC cord-303447-3a7jxl34 169 4 2004 2004 CD cord-303447-3a7jxl34 169 5 , , , cord-303447-3a7jxl34 169 6 11,647 11,647 CD cord-303447-3a7jxl34 169 7 and and CC cord-303447-3a7jxl34 169 8 more more JJR cord-303447-3a7jxl34 169 9 than than IN cord-303447-3a7jxl34 169 10 18,000 18,000 CD cord-303447-3a7jxl34 169 11 cases case NNS cord-303447-3a7jxl34 169 12 of of IN cord-303447-3a7jxl34 169 13 pertussis pertussis NN cord-303447-3a7jxl34 169 14 were be VBD cord-303447-3a7jxl34 169 15 reported report VBN cord-303447-3a7jxl34 169 16 to to IN cord-303447-3a7jxl34 169 17 the the DT cord-303447-3a7jxl34 169 18 CDC CDC NNP cord-303447-3a7jxl34 169 19 , , , cord-303447-3a7jxl34 169 20 respectively respectively RB cord-303447-3a7jxl34 169 21 [ [ -LRB- cord-303447-3a7jxl34 169 22 53 53 CD cord-303447-3a7jxl34 169 23 ] ] -RRB- cord-303447-3a7jxl34 169 24 . . . cord-303447-3a7jxl34 170 1 Much much JJ cord-303447-3a7jxl34 170 2 of of IN cord-303447-3a7jxl34 170 3 the the DT cord-303447-3a7jxl34 170 4 reported report VBN cord-303447-3a7jxl34 170 5 increase increase NN cord-303447-3a7jxl34 170 6 is be VBZ cord-303447-3a7jxl34 170 7 thought think VBN cord-303447-3a7jxl34 170 8 to to TO cord-303447-3a7jxl34 170 9 be be VB cord-303447-3a7jxl34 170 10 due due JJ cord-303447-3a7jxl34 170 11 to to IN cord-303447-3a7jxl34 170 12 increasing increase VBG cord-303447-3a7jxl34 170 13 physician physician NN cord-303447-3a7jxl34 170 14 recognition recognition NN cord-303447-3a7jxl34 170 15 of of IN cord-303447-3a7jxl34 170 16 pertussis pertussis NN cord-303447-3a7jxl34 170 17 as as IN cord-303447-3a7jxl34 170 18 a a DT cord-303447-3a7jxl34 170 19 nonspecific nonspecific JJ cord-303447-3a7jxl34 170 20 , , , cord-303447-3a7jxl34 170 21 persistent persistent JJ cord-303447-3a7jxl34 170 22 cough cough NN cord-303447-3a7jxl34 170 23 illness illness NN cord-303447-3a7jxl34 170 24 in in IN cord-303447-3a7jxl34 170 25 adolescents adolescent NNS cord-303447-3a7jxl34 170 26 and and CC cord-303447-3a7jxl34 170 27 adults adult NNS cord-303447-3a7jxl34 170 28 , , , cord-303447-3a7jxl34 170 29 coupled couple VBN cord-303447-3a7jxl34 170 30 with with IN cord-303447-3a7jxl34 170 31 increasing increase VBG cord-303447-3a7jxl34 170 32 use use NN cord-303447-3a7jxl34 170 33 of of IN cord-303447-3a7jxl34 170 34 polymerase polymerase NN cord-303447-3a7jxl34 170 35 chain chain NN cord-303447-3a7jxl34 170 36 reaction reaction NN cord-303447-3a7jxl34 170 37 testing testing NN cord-303447-3a7jxl34 170 38 for for IN cord-303447-3a7jxl34 170 39 diagnosis diagnosis NN cord-303447-3a7jxl34 170 40 of of IN cord-303447-3a7jxl34 170 41 all all DT cord-303447-3a7jxl34 170 42 age age NN cord-303447-3a7jxl34 170 43 groups group NNS cord-303447-3a7jxl34 170 44 . . . cord-303447-3a7jxl34 171 1 How how WRB cord-303447-3a7jxl34 171 2 much much JJ cord-303447-3a7jxl34 171 3 of of IN cord-303447-3a7jxl34 171 4 the the DT cord-303447-3a7jxl34 171 5 reported report VBN cord-303447-3a7jxl34 171 6 increase increase NN cord-303447-3a7jxl34 171 7 is be VBZ cord-303447-3a7jxl34 171 8 due due JJ cord-303447-3a7jxl34 171 9 to to IN cord-303447-3a7jxl34 171 10 enhanced enhance VBN cord-303447-3a7jxl34 171 11 surveillance surveillance NN cord-303447-3a7jxl34 171 12 or or CC cord-303447-3a7jxl34 171 13 improved improve VBN cord-303447-3a7jxl34 171 14 diagnostic diagnostic JJ cord-303447-3a7jxl34 171 15 methodology methodology NN cord-303447-3a7jxl34 171 16 is be VBZ cord-303447-3a7jxl34 171 17 unclear unclear JJ cord-303447-3a7jxl34 171 18 . . . cord-303447-3a7jxl34 172 1 One one CD cord-303447-3a7jxl34 172 2 study study NN cord-303447-3a7jxl34 172 3 suggested suggest VBD cord-303447-3a7jxl34 172 4 that that IN cord-303447-3a7jxl34 172 5 a a DT cord-303447-3a7jxl34 172 6 true true JJ cord-303447-3a7jxl34 172 7 increase increase NN cord-303447-3a7jxl34 172 8 in in IN cord-303447-3a7jxl34 172 9 the the DT cord-303447-3a7jxl34 172 10 incidence incidence NN cord-303447-3a7jxl34 172 11 of of IN cord-303447-3a7jxl34 172 12 pertussis pertussis NN cord-303447-3a7jxl34 172 13 disease disease NN cord-303447-3a7jxl34 172 14 occurred occur VBD cord-303447-3a7jxl34 172 15 in in IN cord-303447-3a7jxl34 172 16 young young JJ cord-303447-3a7jxl34 172 17 infants infant NNS cord-303447-3a7jxl34 172 18 in in IN cord-303447-3a7jxl34 172 19 the the DT cord-303447-3a7jxl34 172 20 United United NNP cord-303447-3a7jxl34 172 21 States States NNP cord-303447-3a7jxl34 172 22 between between IN cord-303447-3a7jxl34 172 23 1980 1980 CD cord-303447-3a7jxl34 172 24 and and CC cord-303447-3a7jxl34 172 25 1999 1999 CD cord-303447-3a7jxl34 172 26 [ [ -LRB- cord-303447-3a7jxl34 172 27 54 54 CD cord-303447-3a7jxl34 172 28 ] ] -RRB- cord-303447-3a7jxl34 172 29 . . . cord-303447-3a7jxl34 173 1 The the DT cord-303447-3a7jxl34 173 2 burden burden NN cord-303447-3a7jxl34 173 3 of of IN cord-303447-3a7jxl34 173 4 pertussis pertussis NN cord-303447-3a7jxl34 173 5 disease disease NN cord-303447-3a7jxl34 173 6 in in IN cord-303447-3a7jxl34 173 7 adolescents adolescent NNS cord-303447-3a7jxl34 173 8 is be VBZ cord-303447-3a7jxl34 173 9 substantial substantial JJ cord-303447-3a7jxl34 173 10 . . . cord-303447-3a7jxl34 174 1 Of of IN cord-303447-3a7jxl34 174 2 the the DT cord-303447-3a7jxl34 174 3 reported report VBN cord-303447-3a7jxl34 174 4 cases case NNS cord-303447-3a7jxl34 174 5 of of IN cord-303447-3a7jxl34 174 6 pertussis pertussis NN cord-303447-3a7jxl34 174 7 in in IN cord-303447-3a7jxl34 174 8 the the DT cord-303447-3a7jxl34 174 9 United United NNP cord-303447-3a7jxl34 174 10 States States NNP cord-303447-3a7jxl34 174 11 in in IN cord-303447-3a7jxl34 174 12 2003 2003 CD cord-303447-3a7jxl34 174 13 , , , cord-303447-3a7jxl34 174 14 39 39 CD cord-303447-3a7jxl34 174 15 % % NN cord-303447-3a7jxl34 174 16 were be VBD cord-303447-3a7jxl34 174 17 in in IN cord-303447-3a7jxl34 174 18 adolescents adolescent NNS cord-303447-3a7jxl34 174 19 ; ; : cord-303447-3a7jxl34 174 20 the the DT cord-303447-3a7jxl34 174 21 true true JJ cord-303447-3a7jxl34 174 22 number number NN cord-303447-3a7jxl34 174 23 of of IN cord-303447-3a7jxl34 174 24 cases case NNS cord-303447-3a7jxl34 174 25 is be VBZ cord-303447-3a7jxl34 174 26 likely likely JJ cord-303447-3a7jxl34 174 27 to to TO cord-303447-3a7jxl34 174 28 be be VB cord-303447-3a7jxl34 174 29 much much RB cord-303447-3a7jxl34 174 30 higher high JJR cord-303447-3a7jxl34 174 31 ( ( -LRB- cord-303447-3a7jxl34 174 32 CDC CDC NNP cord-303447-3a7jxl34 174 33 , , , cord-303447-3a7jxl34 174 34 unpublished unpublished JJ cord-303447-3a7jxl34 174 35 data datum NNS cord-303447-3a7jxl34 174 36 ) ) -RRB- cord-303447-3a7jxl34 174 37 . . . cord-303447-3a7jxl34 175 1 Although although IN cord-303447-3a7jxl34 175 2 pertussis pertussis NN cord-303447-3a7jxl34 175 3 is be VBZ cord-303447-3a7jxl34 175 4 rarely rarely RB cord-303447-3a7jxl34 175 5 life life NN cord-303447-3a7jxl34 175 6 - - HYPH cord-303447-3a7jxl34 175 7 threatening threaten VBG cord-303447-3a7jxl34 175 8 in in IN cord-303447-3a7jxl34 175 9 adolescents adolescent NNS cord-303447-3a7jxl34 175 10 , , , cord-303447-3a7jxl34 175 11 the the DT cord-303447-3a7jxl34 175 12 morbidity morbidity NN cord-303447-3a7jxl34 175 13 and and CC cord-303447-3a7jxl34 175 14 societal societal JJ cord-303447-3a7jxl34 175 15 costs cost NNS cord-303447-3a7jxl34 175 16 associated associate VBN cord-303447-3a7jxl34 175 17 with with IN cord-303447-3a7jxl34 175 18 adolescent adolescent JJ cord-303447-3a7jxl34 175 19 pertussis pertussis NN cord-303447-3a7jxl34 175 20 disease disease NN cord-303447-3a7jxl34 175 21 are be VBP cord-303447-3a7jxl34 175 22 important important JJ cord-303447-3a7jxl34 175 23 [ [ -LRB- cord-303447-3a7jxl34 175 24 55 55 CD cord-303447-3a7jxl34 175 25 ] ] -RRB- cord-303447-3a7jxl34 175 26 . . . cord-303447-3a7jxl34 176 1 In in IN cord-303447-3a7jxl34 176 2 a a DT cord-303447-3a7jxl34 176 3 Canadian canadian JJ cord-303447-3a7jxl34 176 4 study study NN cord-303447-3a7jxl34 176 5 , , , cord-303447-3a7jxl34 176 6 47 47 CD cord-303447-3a7jxl34 176 7 % % NN cord-303447-3a7jxl34 176 8 of of IN cord-303447-3a7jxl34 176 9 adolescents adolescent NNS cord-303447-3a7jxl34 176 10 with with IN cord-303447-3a7jxl34 176 11 pertussis pertussis NN cord-303447-3a7jxl34 176 12 reported report VBD cord-303447-3a7jxl34 176 13 a a DT cord-303447-3a7jxl34 176 14 cough cough NN cord-303447-3a7jxl34 176 15 duration duration NN cord-303447-3a7jxl34 176 16 of of IN cord-303447-3a7jxl34 176 17 at at RB cord-303447-3a7jxl34 176 18 least least JJS cord-303447-3a7jxl34 176 19 9 9 CD cord-303447-3a7jxl34 176 20 weeks week NNS cord-303447-3a7jxl34 176 21 [ [ -LRB- cord-303447-3a7jxl34 176 22 56 56 CD cord-303447-3a7jxl34 176 23 ] ] -RRB- cord-303447-3a7jxl34 176 24 . . . cord-303447-3a7jxl34 177 1 Paroxysms paroxysm NNS cord-303447-3a7jxl34 177 2 , , , cord-303447-3a7jxl34 177 3 shortness shortness NN cord-303447-3a7jxl34 177 4 of of IN cord-303447-3a7jxl34 177 5 breath breath NN cord-303447-3a7jxl34 177 6 , , , cord-303447-3a7jxl34 177 7 posttussive posttussive JJ cord-303447-3a7jxl34 177 8 vomiting vomiting NN cord-303447-3a7jxl34 177 9 , , , cord-303447-3a7jxl34 177 10 and and CC cord-303447-3a7jxl34 177 11 difficulty difficulty NN cord-303447-3a7jxl34 177 12 sleeping sleep VBG cord-303447-3a7jxl34 177 13 occur occur VBP cord-303447-3a7jxl34 177 14 commonly commonly RB cord-303447-3a7jxl34 177 15 in in IN cord-303447-3a7jxl34 177 16 adolescents adolescent NNS cord-303447-3a7jxl34 177 17 with with IN cord-303447-3a7jxl34 177 18 pertussis pertussis NN cord-303447-3a7jxl34 177 19 disease disease NN cord-303447-3a7jxl34 177 20 [ [ -LRB- cord-303447-3a7jxl34 177 21 55 55 CD cord-303447-3a7jxl34 177 22 , , , cord-303447-3a7jxl34 177 23 56 56 CD cord-303447-3a7jxl34 177 24 ] ] -RRB- cord-303447-3a7jxl34 177 25 . . . cord-303447-3a7jxl34 178 1 To to TO cord-303447-3a7jxl34 178 2 reduce reduce VB cord-303447-3a7jxl34 178 3 pertussis pertussis NN cord-303447-3a7jxl34 178 4 disease disease NN cord-303447-3a7jxl34 178 5 in in IN cord-303447-3a7jxl34 178 6 adolescents adolescent NNS cord-303447-3a7jxl34 178 7 , , , cord-303447-3a7jxl34 178 8 some some DT cord-303447-3a7jxl34 178 9 countries country NNS cord-303447-3a7jxl34 178 10 have have VBP cord-303447-3a7jxl34 178 11 recommended recommend VBN cord-303447-3a7jxl34 178 12 an an DT cord-303447-3a7jxl34 178 13 adolescent adolescent JJ cord-303447-3a7jxl34 178 14 booster booster NN cord-303447-3a7jxl34 178 15 dose dose NN cord-303447-3a7jxl34 178 16 . . . cord-303447-3a7jxl34 179 1 In in IN cord-303447-3a7jxl34 179 2 summer summer NN cord-303447-3a7jxl34 179 3 2004 2004 CD cord-303447-3a7jxl34 179 4 , , , cord-303447-3a7jxl34 179 5 two two CD cord-303447-3a7jxl34 179 6 manufacturers manufacturer NNS cord-303447-3a7jxl34 179 7 submitted submit VBD cord-303447-3a7jxl34 179 8 BLAs bla NNS cord-303447-3a7jxl34 179 9 to to IN cord-303447-3a7jxl34 179 10 the the DT cord-303447-3a7jxl34 179 11 FDA FDA NNP cord-303447-3a7jxl34 179 12 for for IN cord-303447-3a7jxl34 179 13 use use NN cord-303447-3a7jxl34 179 14 of of IN cord-303447-3a7jxl34 179 15 adolescent adolescent JJ cord-303447-3a7jxl34 179 16 and and CC cord-303447-3a7jxl34 179 17 adult adult NN cord-303447-3a7jxl34 179 18 pertussis pertussis NN cord-303447-3a7jxl34 179 19 vaccines vaccine NNS cord-303447-3a7jxl34 179 20 in in IN cord-303447-3a7jxl34 179 21 the the DT cord-303447-3a7jxl34 179 22 United United NNP cord-303447-3a7jxl34 179 23 States States NNP cord-303447-3a7jxl34 179 24 ( ( -LRB- cord-303447-3a7jxl34 179 25 tetanus tetanus JJ cord-303447-3a7jxl34 179 26 toxoid toxoid NN cord-303447-3a7jxl34 179 27 , , , cord-303447-3a7jxl34 179 28 reduced reduce VBN cord-303447-3a7jxl34 179 29 diphtheria diphtheria NN cord-303447-3a7jxl34 179 30 toxoid toxoid NN cord-303447-3a7jxl34 179 31 and and CC cord-303447-3a7jxl34 179 32 acellular acellular JJ cord-303447-3a7jxl34 179 33 pertussis pertussis NN cord-303447-3a7jxl34 179 34 vaccine vaccine NN cord-303447-3a7jxl34 179 35 adsorbed adsorb VBN cord-303447-3a7jxl34 179 36 ( ( -LRB- cord-303447-3a7jxl34 179 37 Tdap Tdap NNP cord-303447-3a7jxl34 179 38 ) ) -RRB- cord-303447-3a7jxl34 179 39 . . . cord-303447-3a7jxl34 180 1 The the DT cord-303447-3a7jxl34 180 2 BLA BLA NNP cord-303447-3a7jxl34 180 3 indication indication NN cord-303447-3a7jxl34 180 4 for for IN cord-303447-3a7jxl34 180 5 one one CD cord-303447-3a7jxl34 180 6 vaccine vaccine NN cord-303447-3a7jxl34 180 7 includes include VBZ cord-303447-3a7jxl34 180 8 persons person NNS cord-303447-3a7jxl34 180 9 10 10 CD cord-303447-3a7jxl34 180 10 to to TO cord-303447-3a7jxl34 180 11 18 18 CD cord-303447-3a7jxl34 180 12 years year NNS cord-303447-3a7jxl34 180 13 old old JJ cord-303447-3a7jxl34 180 14 , , , cord-303447-3a7jxl34 180 15 and and CC cord-303447-3a7jxl34 180 16 the the DT cord-303447-3a7jxl34 180 17 other other JJ cord-303447-3a7jxl34 180 18 includes include VBZ cord-303447-3a7jxl34 180 19 persons person NNS cord-303447-3a7jxl34 180 20 11 11 CD cord-303447-3a7jxl34 180 21 to to IN cord-303447-3a7jxl34 180 22 64 64 CD cord-303447-3a7jxl34 180 23 years year NNS cord-303447-3a7jxl34 180 24 old old JJ cord-303447-3a7jxl34 180 25 . . . cord-303447-3a7jxl34 181 1 Policymakers policymaker NNS cord-303447-3a7jxl34 181 2 are be VBP cord-303447-3a7jxl34 181 3 reviewing review VBG cord-303447-3a7jxl34 181 4 several several JJ cord-303447-3a7jxl34 181 5 strategies strategy NNS cord-303447-3a7jxl34 181 6 for for IN cord-303447-3a7jxl34 181 7 pertussis pertussis NN cord-303447-3a7jxl34 181 8 vaccination vaccination NN cord-303447-3a7jxl34 181 9 in in IN cord-303447-3a7jxl34 181 10 adolescents adolescent NNS cord-303447-3a7jxl34 181 11 and and CC cord-303447-3a7jxl34 181 12 adults adult NNS cord-303447-3a7jxl34 181 13 . . . cord-303447-3a7jxl34 182 1 A a DT cord-303447-3a7jxl34 182 2 cost cost NN cord-303447-3a7jxl34 182 3 - - HYPH cord-303447-3a7jxl34 182 4 benefit benefit NN cord-303447-3a7jxl34 182 5 analysis analysis NN cord-303447-3a7jxl34 182 6 in in IN cord-303447-3a7jxl34 182 7 the the DT cord-303447-3a7jxl34 182 8 United United NNP cord-303447-3a7jxl34 182 9 States States NNP cord-303447-3a7jxl34 182 10 found find VBD cord-303447-3a7jxl34 182 11 universal universal JJ cord-303447-3a7jxl34 182 12 vaccination vaccination NN cord-303447-3a7jxl34 182 13 for for IN cord-303447-3a7jxl34 182 14 persons person NNS cord-303447-3a7jxl34 182 15 10 10 CD cord-303447-3a7jxl34 182 16 to to TO cord-303447-3a7jxl34 182 17 19 19 CD cord-303447-3a7jxl34 182 18 years year NNS cord-303447-3a7jxl34 182 19 old old JJ cord-303447-3a7jxl34 182 20 to to TO cord-303447-3a7jxl34 182 21 be be VB cord-303447-3a7jxl34 182 22 the the DT cord-303447-3a7jxl34 182 23 most most RBS cord-303447-3a7jxl34 182 24 economic economic JJ cord-303447-3a7jxl34 182 25 strategy strategy NN cord-303447-3a7jxl34 182 26 [ [ -LRB- cord-303447-3a7jxl34 182 27 57 57 CD cord-303447-3a7jxl34 182 28 ] ] -RRB- cord-303447-3a7jxl34 182 29 . . . cord-303447-3a7jxl34 183 1 The the DT cord-303447-3a7jxl34 183 2 expected expected JJ cord-303447-3a7jxl34 183 3 impact impact NN cord-303447-3a7jxl34 183 4 of of IN cord-303447-3a7jxl34 183 5 adolescent adolescent JJ cord-303447-3a7jxl34 183 6 pertussis pertussis NN cord-303447-3a7jxl34 183 7 vaccination vaccination NN cord-303447-3a7jxl34 183 8 would would MD cord-303447-3a7jxl34 183 9 be be VB cord-303447-3a7jxl34 183 10 to to TO cord-303447-3a7jxl34 183 11 reduce reduce VB cord-303447-3a7jxl34 183 12 the the DT cord-303447-3a7jxl34 183 13 risk risk NN cord-303447-3a7jxl34 183 14 of of IN cord-303447-3a7jxl34 183 15 pertussis pertussis NN cord-303447-3a7jxl34 183 16 in in IN cord-303447-3a7jxl34 183 17 vaccinated vaccinate VBN cord-303447-3a7jxl34 183 18 adolescents adolescent NNS cord-303447-3a7jxl34 183 19 . . . cord-303447-3a7jxl34 184 1 Ideally ideally RB cord-303447-3a7jxl34 184 2 , , , cord-303447-3a7jxl34 184 3 another another DT cord-303447-3a7jxl34 184 4 public public JJ cord-303447-3a7jxl34 184 5 health health NN cord-303447-3a7jxl34 184 6 goal goal NN cord-303447-3a7jxl34 184 7 of of IN cord-303447-3a7jxl34 184 8 pertussis pertussis NN cord-303447-3a7jxl34 184 9 vaccination vaccination NN cord-303447-3a7jxl34 184 10 is be VBZ cord-303447-3a7jxl34 184 11 to to TO cord-303447-3a7jxl34 184 12 reduce reduce VB cord-303447-3a7jxl34 184 13 transmission transmission NN cord-303447-3a7jxl34 184 14 to to IN cord-303447-3a7jxl34 184 15 infants infant NNS cord-303447-3a7jxl34 184 16 younger young JJR cord-303447-3a7jxl34 184 17 than than IN cord-303447-3a7jxl34 184 18 6 6 CD cord-303447-3a7jxl34 184 19 months month NNS cord-303447-3a7jxl34 184 20 old old JJ cord-303447-3a7jxl34 184 21 who who WP cord-303447-3a7jxl34 184 22 have have VBP cord-303447-3a7jxl34 184 23 not not RB cord-303447-3a7jxl34 184 24 completed complete VBN cord-303447-3a7jxl34 184 25 the the DT cord-303447-3a7jxl34 184 26 primary primary JJ cord-303447-3a7jxl34 184 27 vaccination vaccination NN cord-303447-3a7jxl34 184 28 series series NN cord-303447-3a7jxl34 184 29 and and CC cord-303447-3a7jxl34 184 30 are be VBP cord-303447-3a7jxl34 184 31 at at IN cord-303447-3a7jxl34 184 32 highest high JJS cord-303447-3a7jxl34 184 33 risk risk NN cord-303447-3a7jxl34 184 34 of of IN cord-303447-3a7jxl34 184 35 death death NN cord-303447-3a7jxl34 184 36 from from IN cord-303447-3a7jxl34 184 37 pertussis pertussis NN cord-303447-3a7jxl34 184 38 . . . cord-303447-3a7jxl34 185 1 The the DT cord-303447-3a7jxl34 185 2 role role NN cord-303447-3a7jxl34 185 3 of of IN cord-303447-3a7jxl34 185 4 an an DT cord-303447-3a7jxl34 185 5 adolescent adolescent JJ cord-303447-3a7jxl34 185 6 vaccination vaccination NN cord-303447-3a7jxl34 185 7 program program NN cord-303447-3a7jxl34 185 8 in in IN cord-303447-3a7jxl34 185 9 reducing reduce VBG cord-303447-3a7jxl34 185 10 transmission transmission NN cord-303447-3a7jxl34 185 11 to to IN cord-303447-3a7jxl34 185 12 infants infant NNS cord-303447-3a7jxl34 185 13 is be VBZ cord-303447-3a7jxl34 185 14 unknown unknown JJ cord-303447-3a7jxl34 185 15 . . . cord-303447-3a7jxl34 186 1 Vaccinating vaccinate VBG cord-303447-3a7jxl34 186 2 mothers mother NNS cord-303447-3a7jxl34 186 3 and and CC cord-303447-3a7jxl34 186 4 other other JJ cord-303447-3a7jxl34 186 5 close close JJ cord-303447-3a7jxl34 186 6 family family NN cord-303447-3a7jxl34 186 7 members member NNS cord-303447-3a7jxl34 186 8 of of IN cord-303447-3a7jxl34 186 9 young young JJ cord-303447-3a7jxl34 186 10 infants infant NNS cord-303447-3a7jxl34 186 11 , , , cord-303447-3a7jxl34 186 12 referred refer VBD cord-303447-3a7jxl34 186 13 to to IN cord-303447-3a7jxl34 186 14 as as IN cord-303447-3a7jxl34 186 15 a a DT cord-303447-3a7jxl34 186 16 ' ' '' cord-303447-3a7jxl34 186 17 ' ' '' cord-303447-3a7jxl34 186 18 cocoon cocoon NN cord-303447-3a7jxl34 186 19 strategy strategy NN cord-303447-3a7jxl34 186 20 , , , cord-303447-3a7jxl34 186 21 ' ' '' cord-303447-3a7jxl34 186 22 ' ' '' cord-303447-3a7jxl34 186 23 is be VBZ cord-303447-3a7jxl34 186 24 one one CD cord-303447-3a7jxl34 186 25 method method NN cord-303447-3a7jxl34 186 26 under under IN cord-303447-3a7jxl34 186 27 consideration consideration NN cord-303447-3a7jxl34 186 28 to to TO cord-303447-3a7jxl34 186 29 decrease decrease VB cord-303447-3a7jxl34 186 30 pertussis pertussis NN cord-303447-3a7jxl34 186 31 transmission transmission NN cord-303447-3a7jxl34 186 32 to to IN cord-303447-3a7jxl34 186 33 infants infant NNS cord-303447-3a7jxl34 186 34 . . . cord-303447-3a7jxl34 187 1 One one CD cord-303447-3a7jxl34 187 2 study study NN cord-303447-3a7jxl34 187 3 suggested suggest VBD cord-303447-3a7jxl34 187 4 that that IN cord-303447-3a7jxl34 187 5 adult adult NN cord-303447-3a7jxl34 187 6 family family NN cord-303447-3a7jxl34 187 7 members member NNS cord-303447-3a7jxl34 187 8 are be VBP cord-303447-3a7jxl34 187 9 the the DT cord-303447-3a7jxl34 187 10 most most RBS cord-303447-3a7jxl34 187 11 frequently frequently RB cord-303447-3a7jxl34 187 12 identified identify VBN cord-303447-3a7jxl34 187 13 source source NN cord-303447-3a7jxl34 187 14 for for IN cord-303447-3a7jxl34 187 15 pertussis pertussis NN cord-303447-3a7jxl34 187 16 transmission transmission NN cord-303447-3a7jxl34 187 17 to to IN cord-303447-3a7jxl34 187 18 infants infant NNS cord-303447-3a7jxl34 187 19 [ [ -LRB- cord-303447-3a7jxl34 187 20 58 58 CD cord-303447-3a7jxl34 187 21 ] ] -RRB- cord-303447-3a7jxl34 187 22 . . . cord-303447-3a7jxl34 188 1 Universal universal JJ cord-303447-3a7jxl34 188 2 replacement replacement NN cord-303447-3a7jxl34 188 3 of of IN cord-303447-3a7jxl34 188 4 the the DT cord-303447-3a7jxl34 188 5 Td Td NNP cord-303447-3a7jxl34 188 6 booster booster NN cord-303447-3a7jxl34 188 7 given give VBN cord-303447-3a7jxl34 188 8 every every DT cord-303447-3a7jxl34 188 9 10 10 CD cord-303447-3a7jxl34 188 10 years year NNS cord-303447-3a7jxl34 188 11 with with IN cord-303447-3a7jxl34 188 12 Tdap Tdap NNP cord-303447-3a7jxl34 188 13 is be VBZ cord-303447-3a7jxl34 188 14 another another DT cord-303447-3a7jxl34 188 15 strategy strategy NN cord-303447-3a7jxl34 188 16 being be VBG cord-303447-3a7jxl34 188 17 discussed discuss VBN cord-303447-3a7jxl34 188 18 . . . cord-303447-3a7jxl34 189 1 Finally finally RB cord-303447-3a7jxl34 189 2 , , , cord-303447-3a7jxl34 189 3 vaccinating vaccinate VBG cord-303447-3a7jxl34 189 4 women woman NNS cord-303447-3a7jxl34 189 5 during during IN cord-303447-3a7jxl34 189 6 pregnancy pregnancy NN cord-303447-3a7jxl34 189 7 and and CC cord-303447-3a7jxl34 189 8 vaccinating vaccinate VBG cord-303447-3a7jxl34 189 9 neonates neonate NNS cord-303447-3a7jxl34 189 10 against against IN cord-303447-3a7jxl34 189 11 pertussis pertussis NN cord-303447-3a7jxl34 189 12 have have VBP cord-303447-3a7jxl34 189 13 been be VBN cord-303447-3a7jxl34 189 14 raised raise VBN cord-303447-3a7jxl34 189 15 as as IN cord-303447-3a7jxl34 189 16 potential potential JJ cord-303447-3a7jxl34 189 17 strategies strategy NNS cord-303447-3a7jxl34 189 18 to to TO cord-303447-3a7jxl34 189 19 improve improve VB cord-303447-3a7jxl34 189 20 control control NN cord-303447-3a7jxl34 189 21 of of IN cord-303447-3a7jxl34 189 22 pertussis pertussis NN cord-303447-3a7jxl34 189 23 , , , cord-303447-3a7jxl34 189 24 although although IN cord-303447-3a7jxl34 189 25 pertussis pertussis NN cord-303447-3a7jxl34 189 26 vaccines vaccine NNS cord-303447-3a7jxl34 189 27 for for IN cord-303447-3a7jxl34 189 28 these these DT cord-303447-3a7jxl34 189 29 indications indication NNS cord-303447-3a7jxl34 189 30 are be VBP cord-303447-3a7jxl34 189 31 unlikely unlikely JJ cord-303447-3a7jxl34 189 32 to to TO cord-303447-3a7jxl34 189 33 be be VB cord-303447-3a7jxl34 189 34 licensed license VBN cord-303447-3a7jxl34 189 35 in in IN cord-303447-3a7jxl34 189 36 the the DT cord-303447-3a7jxl34 189 37 United United NNP cord-303447-3a7jxl34 189 38 States States NNP cord-303447-3a7jxl34 189 39 in in IN cord-303447-3a7jxl34 189 40 the the DT cord-303447-3a7jxl34 189 41 near near JJ cord-303447-3a7jxl34 189 42 future future NN cord-303447-3a7jxl34 189 43 [ [ -LRB- cord-303447-3a7jxl34 189 44 59 59 CD cord-303447-3a7jxl34 189 45 , , , cord-303447-3a7jxl34 189 46 60 60 CD cord-303447-3a7jxl34 189 47 ] ] -RRB- cord-303447-3a7jxl34 189 48 . . . cord-303447-3a7jxl34 190 1 More More JJR cord-303447-3a7jxl34 190 2 than than IN cord-303447-3a7jxl34 190 3 200 200 CD cord-303447-3a7jxl34 190 4 types type NNS cord-303447-3a7jxl34 190 5 of of IN cord-303447-3a7jxl34 190 6 papillomaviruses papillomaviruse NNS cord-303447-3a7jxl34 190 7 have have VBP cord-303447-3a7jxl34 190 8 been be VBN cord-303447-3a7jxl34 190 9 recognized recognize VBN cord-303447-3a7jxl34 190 10 on on IN cord-303447-3a7jxl34 190 11 the the DT cord-303447-3a7jxl34 190 12 basis basis NN cord-303447-3a7jxl34 190 13 of of IN cord-303447-3a7jxl34 190 14 DNA dna NN cord-303447-3a7jxl34 190 15 sequence sequence NN cord-303447-3a7jxl34 190 16 analyses analysis NNS cord-303447-3a7jxl34 190 17 [ [ -LRB- cord-303447-3a7jxl34 190 18 61 61 CD cord-303447-3a7jxl34 190 19 ] ] -RRB- cord-303447-3a7jxl34 190 20 . . . cord-303447-3a7jxl34 191 1 Papillomaviruses papillomaviruse NNS cord-303447-3a7jxl34 191 2 are be VBP cord-303447-3a7jxl34 191 3 ubiquitous ubiquitous JJ cord-303447-3a7jxl34 191 4 , , , cord-303447-3a7jxl34 191 5 have have VBP cord-303447-3a7jxl34 191 6 been be VBN cord-303447-3a7jxl34 191 7 detected detect VBN cord-303447-3a7jxl34 191 8 in in IN cord-303447-3a7jxl34 191 9 a a DT cord-303447-3a7jxl34 191 10 wide wide JJ cord-303447-3a7jxl34 191 11 variety variety NN cord-303447-3a7jxl34 191 12 of of IN cord-303447-3a7jxl34 191 13 animals animal NNS cord-303447-3a7jxl34 191 14 and and CC cord-303447-3a7jxl34 191 15 humans human NNS cord-303447-3a7jxl34 191 16 , , , cord-303447-3a7jxl34 191 17 and and CC cord-303447-3a7jxl34 191 18 are be VBP cord-303447-3a7jxl34 191 19 specific specific JJ cord-303447-3a7jxl34 191 20 to to IN cord-303447-3a7jxl34 191 21 their -PRON- PRP$ cord-303447-3a7jxl34 191 22 respective respective JJ cord-303447-3a7jxl34 191 23 hosts host NNS cord-303447-3a7jxl34 191 24 . . . cord-303447-3a7jxl34 192 1 HPV HPV NNP cord-303447-3a7jxl34 192 2 is be VBZ cord-303447-3a7jxl34 192 3 associated associate VBN cord-303447-3a7jxl34 192 4 with with IN cord-303447-3a7jxl34 192 5 a a DT cord-303447-3a7jxl34 192 6 variety variety NN cord-303447-3a7jxl34 192 7 of of IN cord-303447-3a7jxl34 192 8 clinical clinical JJ cord-303447-3a7jxl34 192 9 conditions condition NNS cord-303447-3a7jxl34 192 10 that that WDT cord-303447-3a7jxl34 192 11 range range VBP cord-303447-3a7jxl34 192 12 from from IN cord-303447-3a7jxl34 192 13 benign benign JJ cord-303447-3a7jxl34 192 14 skin skin NN cord-303447-3a7jxl34 192 15 and and CC cord-303447-3a7jxl34 192 16 mucous mucous JJ cord-303447-3a7jxl34 192 17 membrane membrane NN cord-303447-3a7jxl34 192 18 lesions lesion NNS cord-303447-3a7jxl34 192 19 to to IN cord-303447-3a7jxl34 192 20 cancer cancer NN cord-303447-3a7jxl34 192 21 . . . cord-303447-3a7jxl34 193 1 Most Most JJS cord-303447-3a7jxl34 193 2 HPV hpv NN cord-303447-3a7jxl34 193 3 infections infection NNS cord-303447-3a7jxl34 193 4 are be VBP cord-303447-3a7jxl34 193 5 benign benign JJ cord-303447-3a7jxl34 193 6 . . . cord-303447-3a7jxl34 194 1 Clinical clinical JJ cord-303447-3a7jxl34 194 2 manifestations manifestation NNS cord-303447-3a7jxl34 194 3 with with IN cord-303447-3a7jxl34 194 4 the the DT cord-303447-3a7jxl34 194 5 most most RBS cord-303447-3a7jxl34 194 6 frequently frequently RB cord-303447-3a7jxl34 194 7 associated associate VBN cord-303447-3a7jxl34 194 8 HPV hpv NN cord-303447-3a7jxl34 194 9 type type NN cord-303447-3a7jxl34 194 10 are be VBP cord-303447-3a7jxl34 194 11 as as IN cord-303447-3a7jxl34 194 12 follows follow VBZ cord-303447-3a7jxl34 194 13 : : : cord-303447-3a7jxl34 194 14 skin skin NN cord-303447-3a7jxl34 194 15 warts wart NNS cord-303447-3a7jxl34 194 16 ( ( -LRB- cord-303447-3a7jxl34 194 17 types type NNS cord-303447-3a7jxl34 194 18 1 1 CD cord-303447-3a7jxl34 194 19 , , , cord-303447-3a7jxl34 194 20 2 2 CD cord-303447-3a7jxl34 194 21 , , , cord-303447-3a7jxl34 194 22 3 3 CD cord-303447-3a7jxl34 194 23 , , , cord-303447-3a7jxl34 194 24 and and CC cord-303447-3a7jxl34 194 25 10 10 CD cord-303447-3a7jxl34 194 26 ) ) -RRB- cord-303447-3a7jxl34 194 27 , , , cord-303447-3a7jxl34 194 28 recurrent recurrent JJ cord-303447-3a7jxl34 194 29 respiratory respiratory JJ cord-303447-3a7jxl34 194 30 papillomatosis papillomatosis NN cord-303447-3a7jxl34 194 31 ( ( -LRB- cord-303447-3a7jxl34 194 32 types type NNS cord-303447-3a7jxl34 194 33 6 6 CD cord-303447-3a7jxl34 194 34 and and CC cord-303447-3a7jxl34 194 35 11 11 CD cord-303447-3a7jxl34 194 36 ) ) -RRB- cord-303447-3a7jxl34 194 37 , , , cord-303447-3a7jxl34 194 38 condyloma condyloma NNP cord-303447-3a7jxl34 194 39 acuminata acuminata NNP cord-303447-3a7jxl34 194 40 ( ( -LRB- cord-303447-3a7jxl34 194 41 types type NNS cord-303447-3a7jxl34 194 42 6 6 CD cord-303447-3a7jxl34 194 43 and and CC cord-303447-3a7jxl34 194 44 11 11 CD cord-303447-3a7jxl34 194 45 ) ) -RRB- cord-303447-3a7jxl34 194 46 , , , cord-303447-3a7jxl34 194 47 and and CC cord-303447-3a7jxl34 194 48 cervical cervical JJ cord-303447-3a7jxl34 194 49 cancer cancer NN cord-303447-3a7jxl34 194 50 ( ( -LRB- cord-303447-3a7jxl34 194 51 types type NNS cord-303447-3a7jxl34 194 52 16 16 CD cord-303447-3a7jxl34 194 53 , , , cord-303447-3a7jxl34 194 54 18 18 CD cord-303447-3a7jxl34 194 55 , , , cord-303447-3a7jxl34 194 56 31 31 CD cord-303447-3a7jxl34 194 57 , , , cord-303447-3a7jxl34 194 58 33 33 CD cord-303447-3a7jxl34 194 59 , , , cord-303447-3a7jxl34 194 60 and and CC cord-303447-3a7jxl34 194 61 45 45 CD cord-303447-3a7jxl34 194 62 ) ) -RRB- cord-303447-3a7jxl34 194 63 . . . cord-303447-3a7jxl34 195 1 Based base VBN cord-303447-3a7jxl34 195 2 on on IN cord-303447-3a7jxl34 195 3 the the DT cord-303447-3a7jxl34 195 4 association association NN cord-303447-3a7jxl34 195 5 of of IN cord-303447-3a7jxl34 195 6 HPV HPV NNP cord-303447-3a7jxl34 195 7 with with IN cord-303447-3a7jxl34 195 8 cervical cervical JJ cord-303447-3a7jxl34 195 9 cancer cancer NN cord-303447-3a7jxl34 195 10 and and CC cord-303447-3a7jxl34 195 11 precursor precursor NN cord-303447-3a7jxl34 195 12 lesions lesion NNS cord-303447-3a7jxl34 195 13 , , , cord-303447-3a7jxl34 195 14 HPVs HPVs NNP cord-303447-3a7jxl34 195 15 can can MD cord-303447-3a7jxl34 195 16 be be VB cord-303447-3a7jxl34 195 17 grouped group VBN cord-303447-3a7jxl34 195 18 into into IN cord-303447-3a7jxl34 195 19 low low JJ cord-303447-3a7jxl34 195 20 - - HYPH cord-303447-3a7jxl34 195 21 risk risk NN cord-303447-3a7jxl34 195 22 and and CC cord-303447-3a7jxl34 195 23 high high JJ cord-303447-3a7jxl34 195 24 - - HYPH cord-303447-3a7jxl34 195 25 risk risk NN cord-303447-3a7jxl34 195 26 HPV hpv NN cord-303447-3a7jxl34 195 27 types type NNS cord-303447-3a7jxl34 195 28 [ [ -LRB- cord-303447-3a7jxl34 195 29 61 61 CD cord-303447-3a7jxl34 195 30 ] ] -RRB- cord-303447-3a7jxl34 195 31 . . . cord-303447-3a7jxl34 196 1 In in IN cord-303447-3a7jxl34 196 2 the the DT cord-303447-3a7jxl34 196 3 United United NNP cord-303447-3a7jxl34 196 4 States States NNP cord-303447-3a7jxl34 196 5 and and CC cord-303447-3a7jxl34 196 6 Europe Europe NNP cord-303447-3a7jxl34 196 7 , , , cord-303447-3a7jxl34 196 8 HPV HPV NNP cord-303447-3a7jxl34 196 9 16 16 CD cord-303447-3a7jxl34 196 10 accounts account NNS cord-303447-3a7jxl34 196 11 for for IN cord-303447-3a7jxl34 196 12 approximately approximately RB cord-303447-3a7jxl34 196 13 50 50 CD cord-303447-3a7jxl34 196 14 % % NN cord-303447-3a7jxl34 196 15 of of IN cord-303447-3a7jxl34 196 16 the the DT cord-303447-3a7jxl34 196 17 cases case NNS cord-303447-3a7jxl34 196 18 of of IN cord-303447-3a7jxl34 196 19 cervical cervical JJ cord-303447-3a7jxl34 196 20 cancer cancer NN cord-303447-3a7jxl34 196 21 , , , cord-303447-3a7jxl34 196 22 with with IN cord-303447-3a7jxl34 196 23 types type NNS cord-303447-3a7jxl34 196 24 18 18 CD cord-303447-3a7jxl34 196 25 , , , cord-303447-3a7jxl34 196 26 31 31 CD cord-303447-3a7jxl34 196 27 , , , cord-303447-3a7jxl34 196 28 and and CC cord-303447-3a7jxl34 196 29 45 45 CD cord-303447-3a7jxl34 196 30 accounting accounting NN cord-303447-3a7jxl34 196 31 for for IN cord-303447-3a7jxl34 196 32 an an DT cord-303447-3a7jxl34 196 33 additional additional JJ cord-303447-3a7jxl34 196 34 25 25 CD cord-303447-3a7jxl34 196 35 % % NN cord-303447-3a7jxl34 196 36 to to TO cord-303447-3a7jxl34 196 37 30 30 CD cord-303447-3a7jxl34 196 38 % % NN cord-303447-3a7jxl34 196 39 of of IN cord-303447-3a7jxl34 196 40 cases case NNS cord-303447-3a7jxl34 196 41 [ [ -LRB- cord-303447-3a7jxl34 196 42 62 62 CD cord-303447-3a7jxl34 196 43 ] ] -RRB- cord-303447-3a7jxl34 196 44 . . . cord-303447-3a7jxl34 197 1 HPV HPV NNP cord-303447-3a7jxl34 197 2 is be VBZ cord-303447-3a7jxl34 197 3 one one CD cord-303447-3a7jxl34 197 4 of of IN cord-303447-3a7jxl34 197 5 the the DT cord-303447-3a7jxl34 197 6 most most RBS cord-303447-3a7jxl34 197 7 common common JJ cord-303447-3a7jxl34 197 8 causes cause NNS cord-303447-3a7jxl34 197 9 of of IN cord-303447-3a7jxl34 197 10 sexually sexually RB cord-303447-3a7jxl34 197 11 transmitted transmit VBN cord-303447-3a7jxl34 197 12 diseases disease NNS cord-303447-3a7jxl34 197 13 in in IN cord-303447-3a7jxl34 197 14 men man NNS cord-303447-3a7jxl34 197 15 and and CC cord-303447-3a7jxl34 197 16 women woman NNS cord-303447-3a7jxl34 197 17 worldwide worldwide RB cord-303447-3a7jxl34 197 18 , , , cord-303447-3a7jxl34 197 19 causing cause VBG cord-303447-3a7jxl34 197 20 almost almost RB cord-303447-3a7jxl34 197 21 all all DT cord-303447-3a7jxl34 197 22 of of IN cord-303447-3a7jxl34 197 23 the the DT cord-303447-3a7jxl34 197 24 morbidity morbidity NN cord-303447-3a7jxl34 197 25 and and CC cord-303447-3a7jxl34 197 26 mortality mortality NN cord-303447-3a7jxl34 197 27 associated associate VBN cord-303447-3a7jxl34 197 28 with with IN cord-303447-3a7jxl34 197 29 cervical cervical JJ cord-303447-3a7jxl34 197 30 cancer cancer NN cord-303447-3a7jxl34 197 31 [ [ -LRB- cord-303447-3a7jxl34 197 32 61 61 CD cord-303447-3a7jxl34 197 33 ] ] -RRB- cord-303447-3a7jxl34 197 34 . . . cord-303447-3a7jxl34 198 1 Epidemiologic epidemiologic JJ cord-303447-3a7jxl34 198 2 studies study NNS cord-303447-3a7jxl34 198 3 have have VBP cord-303447-3a7jxl34 198 4 shown show VBN cord-303447-3a7jxl34 198 5 that that IN cord-303447-3a7jxl34 198 6 the the DT cord-303447-3a7jxl34 198 7 risk risk NN cord-303447-3a7jxl34 198 8 of of IN cord-303447-3a7jxl34 198 9 contracting contract VBG cord-303447-3a7jxl34 198 10 genital genital JJ cord-303447-3a7jxl34 198 11 HPV HPV NNP cord-303447-3a7jxl34 198 12 infection infection NN cord-303447-3a7jxl34 198 13 and and CC cord-303447-3a7jxl34 198 14 cervical cervical JJ cord-303447-3a7jxl34 198 15 cancer cancer NN cord-303447-3a7jxl34 198 16 is be VBZ cord-303447-3a7jxl34 198 17 related relate VBN cord-303447-3a7jxl34 198 18 directly directly RB cord-303447-3a7jxl34 198 19 to to IN cord-303447-3a7jxl34 198 20 sexual sexual JJ cord-303447-3a7jxl34 198 21 activity activity NN cord-303447-3a7jxl34 198 22 . . . cord-303447-3a7jxl34 199 1 Several several JJ cord-303447-3a7jxl34 199 2 specific specific JJ cord-303447-3a7jxl34 199 3 factors factor NNS cord-303447-3a7jxl34 199 4 increase increase VBP cord-303447-3a7jxl34 199 5 the the DT cord-303447-3a7jxl34 199 6 risk risk NN cord-303447-3a7jxl34 199 7 of of IN cord-303447-3a7jxl34 199 8 becoming become VBG cord-303447-3a7jxl34 199 9 infected infect VBN cord-303447-3a7jxl34 199 10 with with IN cord-303447-3a7jxl34 199 11 HPV HPV NNP cord-303447-3a7jxl34 199 12 , , , cord-303447-3a7jxl34 199 13 including include VBG cord-303447-3a7jxl34 199 14 multiple multiple JJ cord-303447-3a7jxl34 199 15 sexual sexual JJ cord-303447-3a7jxl34 199 16 partners partner NNS cord-303447-3a7jxl34 199 17 at at IN cord-303447-3a7jxl34 199 18 any any DT cord-303447-3a7jxl34 199 19 time time NN cord-303447-3a7jxl34 199 20 , , , cord-303447-3a7jxl34 199 21 having have VBG cord-303447-3a7jxl34 199 22 sex sex NN cord-303447-3a7jxl34 199 23 with with IN cord-303447-3a7jxl34 199 24 a a DT cord-303447-3a7jxl34 199 25 person person NN cord-303447-3a7jxl34 199 26 who who WP cord-303447-3a7jxl34 199 27 has have VBZ cord-303447-3a7jxl34 199 28 had have VBN cord-303447-3a7jxl34 199 29 multiple multiple JJ cord-303447-3a7jxl34 199 30 sexual sexual JJ cord-303447-3a7jxl34 199 31 partners partner NNS cord-303447-3a7jxl34 199 32 , , , cord-303447-3a7jxl34 199 33 sexual sexual JJ cord-303447-3a7jxl34 199 34 activity activity NN cord-303447-3a7jxl34 199 35 at at IN cord-303447-3a7jxl34 199 36 an an DT cord-303447-3a7jxl34 199 37 early early JJ cord-303447-3a7jxl34 199 38 age age NN cord-303447-3a7jxl34 199 39 , , , cord-303447-3a7jxl34 199 40 presence presence NN cord-303447-3a7jxl34 199 41 of of IN cord-303447-3a7jxl34 199 42 other other JJ cord-303447-3a7jxl34 199 43 sexually sexually RB cord-303447-3a7jxl34 199 44 transmitted transmit VBN cord-303447-3a7jxl34 199 45 diseases disease NNS cord-303447-3a7jxl34 199 46 , , , cord-303447-3a7jxl34 199 47 and and CC cord-303447-3a7jxl34 199 48 HPV HPV NNP cord-303447-3a7jxl34 199 49 type type NN cord-303447-3a7jxl34 199 50 . . . cord-303447-3a7jxl34 200 1 Vaccination vaccination NN cord-303447-3a7jxl34 200 2 against against IN cord-303447-3a7jxl34 200 3 high high JJ cord-303447-3a7jxl34 200 4 - - HYPH cord-303447-3a7jxl34 200 5 risk risk NN cord-303447-3a7jxl34 200 6 HPV hpv NN cord-303447-3a7jxl34 200 7 types type NNS cord-303447-3a7jxl34 200 8 could could MD cord-303447-3a7jxl34 200 9 reduce reduce VB cord-303447-3a7jxl34 200 10 substantially substantially RB cord-303447-3a7jxl34 200 11 the the DT cord-303447-3a7jxl34 200 12 incidence incidence NN cord-303447-3a7jxl34 200 13 of of IN cord-303447-3a7jxl34 200 14 cervical cervical JJ cord-303447-3a7jxl34 200 15 cancer cancer NN cord-303447-3a7jxl34 200 16 . . . cord-303447-3a7jxl34 201 1 Administration administration NN cord-303447-3a7jxl34 201 2 of of IN cord-303447-3a7jxl34 201 3 HPV-16 HPV-16 NNP cord-303447-3a7jxl34 201 4 vaccine vaccine NN cord-303447-3a7jxl34 201 5 has have VBZ cord-303447-3a7jxl34 201 6 been be VBN cord-303447-3a7jxl34 201 7 shown show VBN cord-303447-3a7jxl34 201 8 to to TO cord-303447-3a7jxl34 201 9 reduce reduce VB cord-303447-3a7jxl34 201 10 the the DT cord-303447-3a7jxl34 201 11 incidence incidence NN cord-303447-3a7jxl34 201 12 of of IN cord-303447-3a7jxl34 201 13 HPV-16 HPV-16 NNP cord-303447-3a7jxl34 201 14 infection infection NN cord-303447-3a7jxl34 201 15 and and CC cord-303447-3a7jxl34 201 16 HPV hpv NN cord-303447-3a7jxl34 201 17 - - HYPH cord-303447-3a7jxl34 201 18 related relate VBN cord-303447-3a7jxl34 201 19 cervical cervical JJ cord-303447-3a7jxl34 201 20 intraepithelial intraepithelial JJ cord-303447-3a7jxl34 201 21 neoplasia neoplasia NN cord-303447-3a7jxl34 201 22 [ [ -LRB- cord-303447-3a7jxl34 201 23 63 63 CD cord-303447-3a7jxl34 201 24 ] ] -RRB- cord-303447-3a7jxl34 201 25 . . . cord-303447-3a7jxl34 202 1 In in IN cord-303447-3a7jxl34 202 2 addition addition NN cord-303447-3a7jxl34 202 3 , , , cord-303447-3a7jxl34 202 4 a a DT cord-303447-3a7jxl34 202 5 bivalent bivalent JJ cord-303447-3a7jxl34 202 6 HPV HPV NNP cord-303447-3a7jxl34 202 7 vaccine vaccine NN cord-303447-3a7jxl34 202 8 was be VBD cord-303447-3a7jxl34 202 9 efficacious efficacious JJ cord-303447-3a7jxl34 202 10 in in IN cord-303447-3a7jxl34 202 11 preventing prevent VBG cord-303447-3a7jxl34 202 12 persistent persistent JJ cord-303447-3a7jxl34 202 13 cervical cervical JJ cord-303447-3a7jxl34 202 14 infections infection NNS cord-303447-3a7jxl34 202 15 with with IN cord-303447-3a7jxl34 202 16 HPV-16 HPV-16 NNP cord-303447-3a7jxl34 202 17 and and CC cord-303447-3a7jxl34 202 18 HPV-18 HPV-18 NNP cord-303447-3a7jxl34 202 19 and and CC cord-303447-3a7jxl34 202 20 associated associate VBD cord-303447-3a7jxl34 202 21 cytologic cytologic JJ cord-303447-3a7jxl34 202 22 abnormalities abnormality NNS cord-303447-3a7jxl34 202 23 and and CC cord-303447-3a7jxl34 202 24 lesions lesion NNS cord-303447-3a7jxl34 202 25 [ [ -LRB- cord-303447-3a7jxl34 202 26 64 64 CD cord-303447-3a7jxl34 202 27 ] ] -RRB- cord-303447-3a7jxl34 202 28 . . . cord-303447-3a7jxl34 203 1 Currently currently RB cord-303447-3a7jxl34 203 2 , , , cord-303447-3a7jxl34 203 3 two two CD cord-303447-3a7jxl34 203 4 HPV HPV NNP cord-303447-3a7jxl34 203 5 vaccines vaccine NNS cord-303447-3a7jxl34 203 6 are be VBP cord-303447-3a7jxl34 203 7 in in IN cord-303447-3a7jxl34 203 8 the the DT cord-303447-3a7jxl34 203 9 final final JJ cord-303447-3a7jxl34 203 10 stages stage NNS cord-303447-3a7jxl34 203 11 of of IN cord-303447-3a7jxl34 203 12 phase phase NN cord-303447-3a7jxl34 203 13 III iii CD cord-303447-3a7jxl34 203 14 testing testing NN cord-303447-3a7jxl34 203 15 . . . cord-303447-3a7jxl34 204 1 One one CD cord-303447-3a7jxl34 204 2 vaccine vaccine NN cord-303447-3a7jxl34 204 3 contains contain VBZ cord-303447-3a7jxl34 204 4 HPV hpv NN cord-303447-3a7jxl34 204 5 types type NNS cord-303447-3a7jxl34 204 6 16 16 CD cord-303447-3a7jxl34 204 7 , , , cord-303447-3a7jxl34 204 8 18 18 CD cord-303447-3a7jxl34 204 9 , , , cord-303447-3a7jxl34 204 10 6 6 CD cord-303447-3a7jxl34 204 11 , , , cord-303447-3a7jxl34 204 12 and and CC cord-303447-3a7jxl34 204 13 11 11 CD cord-303447-3a7jxl34 204 14 , , , cord-303447-3a7jxl34 204 15 and and CC cord-303447-3a7jxl34 204 16 the the DT cord-303447-3a7jxl34 204 17 second second JJ cord-303447-3a7jxl34 204 18 HPV HPV NNP cord-303447-3a7jxl34 204 19 vaccine vaccine NN cord-303447-3a7jxl34 204 20 contains contain VBZ cord-303447-3a7jxl34 204 21 types type NNS cord-303447-3a7jxl34 204 22 16 16 CD cord-303447-3a7jxl34 204 23 and and CC cord-303447-3a7jxl34 204 24 18 18 CD cord-303447-3a7jxl34 204 25 . . . cord-303447-3a7jxl34 205 1 Applications application NNS cord-303447-3a7jxl34 205 2 for for IN cord-303447-3a7jxl34 205 3 licensure licensure NN cord-303447-3a7jxl34 205 4 are be VBP cord-303447-3a7jxl34 205 5 expected expect VBN cord-303447-3a7jxl34 205 6 to to TO cord-303447-3a7jxl34 205 7 be be VB cord-303447-3a7jxl34 205 8 filed file VBN cord-303447-3a7jxl34 205 9 with with IN cord-303447-3a7jxl34 205 10 the the DT cord-303447-3a7jxl34 205 11 US US NNP cord-303447-3a7jxl34 205 12 FDA FDA NNP cord-303447-3a7jxl34 205 13 in in IN cord-303447-3a7jxl34 205 14 late late JJ cord-303447-3a7jxl34 205 15 2005 2005 CD cord-303447-3a7jxl34 205 16 or or CC cord-303447-3a7jxl34 205 17 2006 2006 CD cord-303447-3a7jxl34 205 18 . . . cord-303447-3a7jxl34 206 1 Rotavirus rotavirus NN cord-303447-3a7jxl34 206 2 is be VBZ cord-303447-3a7jxl34 206 3 a a DT cord-303447-3a7jxl34 206 4 common common JJ cord-303447-3a7jxl34 206 5 cause cause NN cord-303447-3a7jxl34 206 6 of of IN cord-303447-3a7jxl34 206 7 gastrointestinal gastrointestinal JJ cord-303447-3a7jxl34 206 8 tract tract JJ cord-303447-3a7jxl34 206 9 illness illness NN cord-303447-3a7jxl34 206 10 in in IN cord-303447-3a7jxl34 206 11 young young JJ cord-303447-3a7jxl34 206 12 children child NNS cord-303447-3a7jxl34 206 13 . . . cord-303447-3a7jxl34 207 1 By by IN cord-303447-3a7jxl34 207 2 5 5 CD cord-303447-3a7jxl34 207 3 years year NNS cord-303447-3a7jxl34 207 4 of of IN cord-303447-3a7jxl34 207 5 age age NN cord-303447-3a7jxl34 207 6 , , , cord-303447-3a7jxl34 207 7 nearly nearly RB cord-303447-3a7jxl34 207 8 all all DT cord-303447-3a7jxl34 207 9 children child NNS cord-303447-3a7jxl34 207 10 test test VBP cord-303447-3a7jxl34 207 11 seropositive seropositive JJ cord-303447-3a7jxl34 207 12 for for IN cord-303447-3a7jxl34 207 13 rotavirus rotavirus NN cord-303447-3a7jxl34 207 14 , , , cord-303447-3a7jxl34 207 15 indicating indicate VBG cord-303447-3a7jxl34 207 16 previous previous JJ cord-303447-3a7jxl34 207 17 infection infection NN cord-303447-3a7jxl34 207 18 . . . cord-303447-3a7jxl34 208 1 In in IN cord-303447-3a7jxl34 208 2 the the DT cord-303447-3a7jxl34 208 3 United United NNP cord-303447-3a7jxl34 208 4 States States NNP cord-303447-3a7jxl34 208 5 , , , cord-303447-3a7jxl34 208 6 rotavirus rotavirus JJ cord-303447-3a7jxl34 208 7 disease disease NN cord-303447-3a7jxl34 208 8 leads lead VBZ cord-303447-3a7jxl34 208 9 to to IN cord-303447-3a7jxl34 208 10 an an DT cord-303447-3a7jxl34 208 11 estimated estimated JJ cord-303447-3a7jxl34 208 12 600,000 600,000 CD cord-303447-3a7jxl34 208 13 clinic clinic NN cord-303447-3a7jxl34 208 14 visits visit NNS cord-303447-3a7jxl34 208 15 , , , cord-303447-3a7jxl34 208 16 50,000 50,000 CD cord-303447-3a7jxl34 208 17 to to TO cord-303447-3a7jxl34 208 18 60,000 60,000 CD cord-303447-3a7jxl34 208 19 hospital hospital NN cord-303447-3a7jxl34 208 20 admissions admission NNS cord-303447-3a7jxl34 208 21 , , , cord-303447-3a7jxl34 208 22 and and CC cord-303447-3a7jxl34 208 23 20 20 CD cord-303447-3a7jxl34 208 24 to to TO cord-303447-3a7jxl34 208 25 40 40 CD cord-303447-3a7jxl34 208 26 deaths death NNS cord-303447-3a7jxl34 208 27 annually annually RB cord-303447-3a7jxl34 208 28 [ [ -LRB- cord-303447-3a7jxl34 208 29 33 33 CD cord-303447-3a7jxl34 208 30 ] ] -RRB- cord-303447-3a7jxl34 208 31 . . . cord-303447-3a7jxl34 209 1 The the DT cord-303447-3a7jxl34 209 2 first first JJ cord-303447-3a7jxl34 209 3 rotavirus rotavirus JJ cord-303447-3a7jxl34 209 4 vaccine vaccine NN cord-303447-3a7jxl34 209 5 was be VBD cord-303447-3a7jxl34 209 6 licensed license VBN cord-303447-3a7jxl34 209 7 in in IN cord-303447-3a7jxl34 209 8 the the DT cord-303447-3a7jxl34 209 9 United United NNP cord-303447-3a7jxl34 209 10 States States NNP cord-303447-3a7jxl34 209 11 in in IN cord-303447-3a7jxl34 209 12 1998 1998 CD cord-303447-3a7jxl34 209 13 and and CC cord-303447-3a7jxl34 209 14 was be VBD cord-303447-3a7jxl34 209 15 removed remove VBN cord-303447-3a7jxl34 209 16 from from IN cord-303447-3a7jxl34 209 17 the the DT cord-303447-3a7jxl34 209 18 market market NN cord-303447-3a7jxl34 209 19 and and CC cord-303447-3a7jxl34 209 20 from from IN cord-303447-3a7jxl34 209 21 the the DT cord-303447-3a7jxl34 209 22 immunization immunization NN cord-303447-3a7jxl34 209 23 schedule schedule NN cord-303447-3a7jxl34 209 24 in in IN cord-303447-3a7jxl34 209 25 1999 1999 CD cord-303447-3a7jxl34 209 26 because because IN cord-303447-3a7jxl34 209 27 of of IN cord-303447-3a7jxl34 209 28 an an DT cord-303447-3a7jxl34 209 29 association association NN cord-303447-3a7jxl34 209 30 with with IN cord-303447-3a7jxl34 209 31 intussusception intussusception NN cord-303447-3a7jxl34 209 32 . . . cord-303447-3a7jxl34 210 1 This this DT cord-303447-3a7jxl34 210 2 vaccine vaccine NN cord-303447-3a7jxl34 210 3 was be VBD cord-303447-3a7jxl34 210 4 a a DT cord-303447-3a7jxl34 210 5 tetravalent tetravalent NN cord-303447-3a7jxl34 210 6 rhesus rhesus NNP cord-303447-3a7jxl34 210 7 human human JJ cord-303447-3a7jxl34 210 8 reassortant reassortant JJ cord-303447-3a7jxl34 210 9 vaccine vaccine NN cord-303447-3a7jxl34 210 10 [ [ -LRB- cord-303447-3a7jxl34 210 11 65 65 CD cord-303447-3a7jxl34 210 12 , , , cord-303447-3a7jxl34 210 13 66 66 CD cord-303447-3a7jxl34 210 14 ] ] -RRB- cord-303447-3a7jxl34 210 15 . . . cord-303447-3a7jxl34 211 1 Currently currently RB cord-303447-3a7jxl34 211 2 , , , cord-303447-3a7jxl34 211 3 several several JJ cord-303447-3a7jxl34 211 4 other other JJ cord-303447-3a7jxl34 211 5 rotavirus rotavirus JJ cord-303447-3a7jxl34 211 6 vaccines vaccine NNS cord-303447-3a7jxl34 211 7 are be VBP cord-303447-3a7jxl34 211 8 in in IN cord-303447-3a7jxl34 211 9 different different JJ cord-303447-3a7jxl34 211 10 stages stage NNS cord-303447-3a7jxl34 211 11 of of IN cord-303447-3a7jxl34 211 12 development development NN cord-303447-3a7jxl34 211 13 . . . cord-303447-3a7jxl34 212 1 Two two CD cord-303447-3a7jxl34 212 2 late late JJ cord-303447-3a7jxl34 212 3 - - HYPH cord-303447-3a7jxl34 212 4 stage stage NN cord-303447-3a7jxl34 212 5 vaccines vaccine NNS cord-303447-3a7jxl34 212 6 have have VBP cord-303447-3a7jxl34 212 7 completed complete VBN cord-303447-3a7jxl34 212 8 phase phase NN cord-303447-3a7jxl34 212 9 III iii CD cord-303447-3a7jxl34 212 10 clinical clinical JJ cord-303447-3a7jxl34 212 11 trials trial NNS cord-303447-3a7jxl34 212 12 . . . cord-303447-3a7jxl34 213 1 One one CD cord-303447-3a7jxl34 213 2 vaccine vaccine NN cord-303447-3a7jxl34 213 3 is be VBZ cord-303447-3a7jxl34 213 4 derived derive VBN cord-303447-3a7jxl34 213 5 from from IN cord-303447-3a7jxl34 213 6 a a DT cord-303447-3a7jxl34 213 7 monovalent monovalent JJ cord-303447-3a7jxl34 213 8 human human JJ cord-303447-3a7jxl34 213 9 strain strain NN cord-303447-3a7jxl34 213 10 , , , cord-303447-3a7jxl34 213 11 and and CC cord-303447-3a7jxl34 213 12 the the DT cord-303447-3a7jxl34 213 13 other other JJ cord-303447-3a7jxl34 213 14 is be VBZ cord-303447-3a7jxl34 213 15 a a DT cord-303447-3a7jxl34 213 16 pentavalent pentavalent JJ cord-303447-3a7jxl34 213 17 bovine bovine JJ cord-303447-3a7jxl34 213 18 - - HYPH cord-303447-3a7jxl34 213 19 human human JJ cord-303447-3a7jxl34 213 20 reassortant reassortant JJ cord-303447-3a7jxl34 213 21 vaccine vaccine NN cord-303447-3a7jxl34 213 22 . . . cord-303447-3a7jxl34 214 1 Large large JJ cord-303447-3a7jxl34 214 2 - - HYPH cord-303447-3a7jxl34 214 3 scale scale NN cord-303447-3a7jxl34 214 4 phase phase NN cord-303447-3a7jxl34 214 5 III iii CD cord-303447-3a7jxl34 214 6 trials trial NNS cord-303447-3a7jxl34 214 7 did do VBD cord-303447-3a7jxl34 214 8 not not RB cord-303447-3a7jxl34 214 9 show show VB cord-303447-3a7jxl34 214 10 an an DT cord-303447-3a7jxl34 214 11 association association NN cord-303447-3a7jxl34 214 12 of of IN cord-303447-3a7jxl34 214 13 these these DT cord-303447-3a7jxl34 214 14 vaccines vaccine NNS cord-303447-3a7jxl34 214 15 with with IN cord-303447-3a7jxl34 214 16 intussusception intussusception NN cord-303447-3a7jxl34 214 17 , , , cord-303447-3a7jxl34 214 18 but but CC cord-303447-3a7jxl34 214 19 postlicensure postlicensure NN cord-303447-3a7jxl34 214 20 monitoring monitoring NN cord-303447-3a7jxl34 214 21 is be VBZ cord-303447-3a7jxl34 214 22 planned plan VBN cord-303447-3a7jxl34 214 23 . . . cord-303447-3a7jxl34 215 1 In in IN cord-303447-3a7jxl34 215 2 January January NNP cord-303447-3a7jxl34 215 3 2005 2005 CD cord-303447-3a7jxl34 215 4 , , , cord-303447-3a7jxl34 215 5 Mexico Mexico NNP cord-303447-3a7jxl34 215 6 became become VBD cord-303447-3a7jxl34 215 7 the the DT cord-303447-3a7jxl34 215 8 first first JJ cord-303447-3a7jxl34 215 9 country country NN cord-303447-3a7jxl34 215 10 to to TO cord-303447-3a7jxl34 215 11 make make VB cord-303447-3a7jxl34 215 12 a a DT cord-303447-3a7jxl34 215 13 new new JJ cord-303447-3a7jxl34 215 14 rotavirus rotavirus JJ cord-303447-3a7jxl34 215 15 vaccine vaccine NN cord-303447-3a7jxl34 215 16 available available JJ cord-303447-3a7jxl34 215 17 . . . cord-303447-3a7jxl34 216 1 The the DT cord-303447-3a7jxl34 216 2 company company NN cord-303447-3a7jxl34 216 3 has have VBZ cord-303447-3a7jxl34 216 4 filed file VBN cord-303447-3a7jxl34 216 5 license license NN cord-303447-3a7jxl34 216 6 applications application NNS cord-303447-3a7jxl34 216 7 in in IN cord-303447-3a7jxl34 216 8 more more JJR cord-303447-3a7jxl34 216 9 than than IN cord-303447-3a7jxl34 216 10 20 20 CD cord-303447-3a7jxl34 216 11 other other JJ cord-303447-3a7jxl34 216 12 countries country NNS cord-303447-3a7jxl34 216 13 outside outside IN cord-303447-3a7jxl34 216 14 the the DT cord-303447-3a7jxl34 216 15 United United NNP cord-303447-3a7jxl34 216 16 States States NNP cord-303447-3a7jxl34 216 17 . . . cord-303447-3a7jxl34 217 1 The the DT cord-303447-3a7jxl34 217 2 manufacturer manufacturer NN cord-303447-3a7jxl34 217 3 of of IN cord-303447-3a7jxl34 217 4 the the DT cord-303447-3a7jxl34 217 5 second second JJ cord-303447-3a7jxl34 217 6 rotavirus rotavirus JJ cord-303447-3a7jxl34 217 7 vaccine vaccine NN cord-303447-3a7jxl34 217 8 plans plan NNS cord-303447-3a7jxl34 217 9 to to TO cord-303447-3a7jxl34 217 10 release release VB cord-303447-3a7jxl34 217 11 it -PRON- PRP cord-303447-3a7jxl34 217 12 first first RB cord-303447-3a7jxl34 217 13 in in IN cord-303447-3a7jxl34 217 14 the the DT cord-303447-3a7jxl34 217 15 United United NNP cord-303447-3a7jxl34 217 16 States States NNP cord-303447-3a7jxl34 217 17 after after IN cord-303447-3a7jxl34 217 18 licensure licensure NN cord-303447-3a7jxl34 217 19 by by IN cord-303447-3a7jxl34 217 20 the the DT cord-303447-3a7jxl34 217 21 US US NNP cord-303447-3a7jxl34 217 22 FDA FDA NNP cord-303447-3a7jxl34 217 23 . . . cord-303447-3a7jxl34 218 1 After after IN cord-303447-3a7jxl34 218 2 licensure licensure NN cord-303447-3a7jxl34 218 3 in in IN cord-303447-3a7jxl34 218 4 the the DT cord-303447-3a7jxl34 218 5 United United NNP cord-303447-3a7jxl34 218 6 States States NNP cord-303447-3a7jxl34 218 7 , , , cord-303447-3a7jxl34 218 8 educational educational JJ cord-303447-3a7jxl34 218 9 efforts effort NNS cord-303447-3a7jxl34 218 10 that that WDT cord-303447-3a7jxl34 218 11 address address VBP cord-303447-3a7jxl34 218 12 identifiable identifiable JJ cord-303447-3a7jxl34 218 13 barriers barrier NNS cord-303447-3a7jxl34 218 14 to to IN cord-303447-3a7jxl34 218 15 achieving achieve VBG cord-303447-3a7jxl34 218 16 practitioner practitioner NN cord-303447-3a7jxl34 218 17 advocacy advocacy NN cord-303447-3a7jxl34 218 18 and and CC cord-303447-3a7jxl34 218 19 patient patient JJ cord-303447-3a7jxl34 218 20 acceptance acceptance NN cord-303447-3a7jxl34 218 21 will will MD cord-303447-3a7jxl34 218 22 be be VB cord-303447-3a7jxl34 218 23 necessary necessary JJ cord-303447-3a7jxl34 218 24 to to TO cord-303447-3a7jxl34 218 25 ensure ensure VB cord-303447-3a7jxl34 218 26 implementation implementation NN cord-303447-3a7jxl34 218 27 of of IN cord-303447-3a7jxl34 218 28 rotavirus rotavirus JJ cord-303447-3a7jxl34 218 29 vaccine vaccine NN cord-303447-3a7jxl34 218 30 recommendations recommendation NNS cord-303447-3a7jxl34 218 31 [ [ -LRB- cord-303447-3a7jxl34 218 32 67 67 CD cord-303447-3a7jxl34 218 33 ] ] -RRB- cord-303447-3a7jxl34 218 34 . . . cord-303447-3a7jxl34 219 1 Ensuring ensure VBG cord-303447-3a7jxl34 219 2 physician physician NN cord-303447-3a7jxl34 219 3 acceptance acceptance NN cord-303447-3a7jxl34 219 4 of of IN cord-303447-3a7jxl34 219 5 the the DT cord-303447-3a7jxl34 219 6 vaccine vaccine NN cord-303447-3a7jxl34 219 7 is be VBZ cord-303447-3a7jxl34 219 8 critical critical JJ cord-303447-3a7jxl34 219 9 to to IN cord-303447-3a7jxl34 219 10 achieving achieve VBG cord-303447-3a7jxl34 219 11 high high JJ cord-303447-3a7jxl34 219 12 coverage coverage NN cord-303447-3a7jxl34 219 13 levels level NNS cord-303447-3a7jxl34 219 14 [ [ -LRB- cord-303447-3a7jxl34 219 15 67 67 CD cord-303447-3a7jxl34 219 16 ] ] -RRB- cord-303447-3a7jxl34 219 17 . . . cord-303447-3a7jxl34 220 1 Varicella Varicella NNP cord-303447-3a7jxl34 220 2 vaccine vaccine NN cord-303447-3a7jxl34 220 3 , , , cord-303447-3a7jxl34 220 4 licensed license VBN cord-303447-3a7jxl34 220 5 for for IN cord-303447-3a7jxl34 220 6 use use NN cord-303447-3a7jxl34 220 7 in in IN cord-303447-3a7jxl34 220 8 the the DT cord-303447-3a7jxl34 220 9 United United NNP cord-303447-3a7jxl34 220 10 States States NNP cord-303447-3a7jxl34 220 11 in in IN cord-303447-3a7jxl34 220 12 1995 1995 CD cord-303447-3a7jxl34 220 13 , , , cord-303447-3a7jxl34 220 14 is be VBZ cord-303447-3a7jxl34 220 15 a a DT cord-303447-3a7jxl34 220 16 live live JJ cord-303447-3a7jxl34 220 17 , , , cord-303447-3a7jxl34 220 18 attenuated attenuated JJ cord-303447-3a7jxl34 220 19 virus virus NN cord-303447-3a7jxl34 220 20 vaccine vaccine NN cord-303447-3a7jxl34 220 21 developed develop VBN cord-303447-3a7jxl34 220 22 from from IN cord-303447-3a7jxl34 220 23 the the DT cord-303447-3a7jxl34 220 24 vesicles vesicle NNS cord-303447-3a7jxl34 220 25 of of IN cord-303447-3a7jxl34 220 26 a a DT cord-303447-3a7jxl34 220 27 healthy healthy JJ cord-303447-3a7jxl34 220 28 infected infected JJ cord-303447-3a7jxl34 220 29 child child NN cord-303447-3a7jxl34 220 30 with with IN cord-303447-3a7jxl34 220 31 chickenpox chickenpox NN cord-303447-3a7jxl34 220 32 . . . cord-303447-3a7jxl34 221 1 This this DT cord-303447-3a7jxl34 221 2 vaccine vaccine NN cord-303447-3a7jxl34 221 3 is be VBZ cord-303447-3a7jxl34 221 4 recommended recommend VBN cord-303447-3a7jxl34 221 5 as as IN cord-303447-3a7jxl34 221 6 a a DT cord-303447-3a7jxl34 221 7 single single JJ cord-303447-3a7jxl34 221 8 dose dose NN cord-303447-3a7jxl34 221 9 for for IN cord-303447-3a7jxl34 221 10 children child NNS cord-303447-3a7jxl34 221 11 12 12 CD cord-303447-3a7jxl34 221 12 months month NNS cord-303447-3a7jxl34 221 13 to to IN cord-303447-3a7jxl34 221 14 12 12 CD cord-303447-3a7jxl34 221 15 years year NNS cord-303447-3a7jxl34 221 16 old old JJ cord-303447-3a7jxl34 221 17 . . . cord-303447-3a7jxl34 222 1 Susceptible susceptible JJ cord-303447-3a7jxl34 222 2 persons person NNS cord-303447-3a7jxl34 222 3 13 13 CD cord-303447-3a7jxl34 222 4 years year NNS cord-303447-3a7jxl34 222 5 old old JJ cord-303447-3a7jxl34 222 6 or or CC cord-303447-3a7jxl34 222 7 older old JJR cord-303447-3a7jxl34 222 8 should should MD cord-303447-3a7jxl34 222 9 receive receive VB cord-303447-3a7jxl34 222 10 two two CD cord-303447-3a7jxl34 222 11 doses dose NNS cord-303447-3a7jxl34 222 12 administered administer VBN cord-303447-3a7jxl34 222 13 4 4 CD cord-303447-3a7jxl34 222 14 weeks week NNS cord-303447-3a7jxl34 222 15 apart apart RB cord-303447-3a7jxl34 222 16 . . . cord-303447-3a7jxl34 223 1 Before before IN cord-303447-3a7jxl34 223 2 varicella varicella NN cord-303447-3a7jxl34 223 3 vaccine vaccine NN cord-303447-3a7jxl34 223 4 became become VBD cord-303447-3a7jxl34 223 5 widely widely RB cord-303447-3a7jxl34 223 6 used use VBN cord-303447-3a7jxl34 223 7 , , , cord-303447-3a7jxl34 223 8 varicella varicella NN cord-303447-3a7jxl34 223 9 was be VBD cord-303447-3a7jxl34 223 10 one one CD cord-303447-3a7jxl34 223 11 of of IN cord-303447-3a7jxl34 223 12 the the DT cord-303447-3a7jxl34 223 13 most most RBS cord-303447-3a7jxl34 223 14 recognizable recognizable JJ cord-303447-3a7jxl34 223 15 rashes rash NNS cord-303447-3a7jxl34 223 16 seen see VBN cord-303447-3a7jxl34 223 17 by by IN cord-303447-3a7jxl34 223 18 pediatricians pediatrician NNS cord-303447-3a7jxl34 223 19 and and CC cord-303447-3a7jxl34 223 20 was be VBD cord-303447-3a7jxl34 223 21 associated associate VBN cord-303447-3a7jxl34 223 22 with with IN cord-303447-3a7jxl34 223 23 11,000 11,000 CD cord-303447-3a7jxl34 223 24 hospitalizations hospitalization NNS cord-303447-3a7jxl34 223 25 and and CC cord-303447-3a7jxl34 223 26 100 100 CD cord-303447-3a7jxl34 223 27 deaths death NNS cord-303447-3a7jxl34 223 28 in in IN cord-303447-3a7jxl34 223 29 the the DT cord-303447-3a7jxl34 223 30 United United NNP cord-303447-3a7jxl34 223 31 States States NNP cord-303447-3a7jxl34 223 32 each each DT cord-303447-3a7jxl34 223 33 year year NN cord-303447-3a7jxl34 223 34 [ [ -LRB- cord-303447-3a7jxl34 223 35 68 68 CD cord-303447-3a7jxl34 223 36 ] ] -RRB- cord-303447-3a7jxl34 223 37 . . . cord-303447-3a7jxl34 224 1 In in IN cord-303447-3a7jxl34 224 2 2003 2003 CD cord-303447-3a7jxl34 224 3 , , , cord-303447-3a7jxl34 224 4 the the DT cord-303447-3a7jxl34 224 5 vaccine vaccine NN cord-303447-3a7jxl34 224 6 had have VBD cord-303447-3a7jxl34 224 7 85 85 CD cord-303447-3a7jxl34 224 8 % % NN cord-303447-3a7jxl34 224 9 coverage coverage NN cord-303447-3a7jxl34 224 10 levels level NNS cord-303447-3a7jxl34 224 11 , , , cord-303447-3a7jxl34 224 12 resulting result VBG cord-303447-3a7jxl34 224 13 in in IN cord-303447-3a7jxl34 224 14 a a DT cord-303447-3a7jxl34 224 15 significant significant JJ cord-303447-3a7jxl34 224 16 decrease decrease NN cord-303447-3a7jxl34 224 17 in in IN cord-303447-3a7jxl34 224 18 mortality mortality NN cord-303447-3a7jxl34 224 19 , , , cord-303447-3a7jxl34 224 20 morbidity morbidity NN cord-303447-3a7jxl34 224 21 , , , cord-303447-3a7jxl34 224 22 and and CC cord-303447-3a7jxl34 224 23 hospitalizations hospitalization NNS cord-303447-3a7jxl34 224 24 attributable attributable JJ cord-303447-3a7jxl34 224 25 to to IN cord-303447-3a7jxl34 224 26 varicella varicella NN cord-303447-3a7jxl34 224 27 [ [ -LRB- cord-303447-3a7jxl34 224 28 68 68 CD cord-303447-3a7jxl34 224 29 ] ] -RRB- cord-303447-3a7jxl34 224 30 . . . cord-303447-3a7jxl34 225 1 Breakthrough Breakthrough NNP cord-303447-3a7jxl34 225 2 varicella varicella NN cord-303447-3a7jxl34 225 3 infections infection NNS cord-303447-3a7jxl34 225 4 in in IN cord-303447-3a7jxl34 225 5 vaccinated vaccinated JJ cord-303447-3a7jxl34 225 6 children child NNS cord-303447-3a7jxl34 225 7 occur occur VBP cord-303447-3a7jxl34 225 8 in in IN cord-303447-3a7jxl34 225 9 15 15 CD cord-303447-3a7jxl34 225 10 % % NN cord-303447-3a7jxl34 225 11 of of IN cord-303447-3a7jxl34 225 12 children child NNS cord-303447-3a7jxl34 225 13 exposed expose VBN cord-303447-3a7jxl34 225 14 to to IN cord-303447-3a7jxl34 225 15 varicella varicella NN cord-303447-3a7jxl34 225 16 . . . cord-303447-3a7jxl34 226 1 Breakthrough Breakthrough NNP cord-303447-3a7jxl34 226 2 infections infection NNS cord-303447-3a7jxl34 226 3 usually usually RB cord-303447-3a7jxl34 226 4 are be VBP cord-303447-3a7jxl34 226 5 mild mild JJ cord-303447-3a7jxl34 226 6 ( ( -LRB- cord-303447-3a7jxl34 226 7 b b NN cord-303447-3a7jxl34 226 8 50 50 CD cord-303447-3a7jxl34 226 9 lesions lesion NNS cord-303447-3a7jxl34 226 10 ) ) -RRB- cord-303447-3a7jxl34 226 11 , , , cord-303447-3a7jxl34 226 12 however however RB cord-303447-3a7jxl34 226 13 , , , cord-303447-3a7jxl34 226 14 with with IN cord-303447-3a7jxl34 226 15 few few JJ cord-303447-3a7jxl34 226 16 complications complication NNS cord-303447-3a7jxl34 226 17 [ [ -LRB- cord-303447-3a7jxl34 226 18 69 69 CD cord-303447-3a7jxl34 226 19 ] ] -RRB- cord-303447-3a7jxl34 226 20 . . . cord-303447-3a7jxl34 227 1 Vaccinated vaccinated JJ cord-303447-3a7jxl34 227 2 children child NNS cord-303447-3a7jxl34 227 3 with with IN cord-303447-3a7jxl34 227 4 mild mild JJ cord-303447-3a7jxl34 227 5 disease disease NN cord-303447-3a7jxl34 227 6 were be VBD cord-303447-3a7jxl34 227 7 only only RB cord-303447-3a7jxl34 227 8 one one CD cord-303447-3a7jxl34 227 9 third third NN cord-303447-3a7jxl34 227 10 as as RB cord-303447-3a7jxl34 227 11 contagious contagious JJ cord-303447-3a7jxl34 227 12 as as IN cord-303447-3a7jxl34 227 13 children child NNS cord-303447-3a7jxl34 227 14 with with IN cord-303447-3a7jxl34 227 15 moderate moderate JJ cord-303447-3a7jxl34 227 16 - - HYPH cord-303447-3a7jxl34 227 17 to to IN cord-303447-3a7jxl34 227 18 - - HYPH cord-303447-3a7jxl34 227 19 severe severe JJ cord-303447-3a7jxl34 227 20 disease disease NN cord-303447-3a7jxl34 227 21 , , , cord-303447-3a7jxl34 227 22 whether whether IN cord-303447-3a7jxl34 227 23 they -PRON- PRP cord-303447-3a7jxl34 227 24 were be VBD cord-303447-3a7jxl34 227 25 vaccinated vaccinate VBN cord-303447-3a7jxl34 227 26 or or CC cord-303447-3a7jxl34 227 27 unvaccinated unvaccinated JJ cord-303447-3a7jxl34 227 28 . . . cord-303447-3a7jxl34 228 1 Vaccine vaccine NN cord-303447-3a7jxl34 228 2 effectiveness effectiveness NN cord-303447-3a7jxl34 228 3 for for IN cord-303447-3a7jxl34 228 4 prevention prevention NN cord-303447-3a7jxl34 228 5 of of IN cord-303447-3a7jxl34 228 6 moderate moderate JJ cord-303447-3a7jxl34 228 7 disease disease NN cord-303447-3a7jxl34 228 8 ( ( -LRB- cord-303447-3a7jxl34 228 9 N n CD cord-303447-3a7jxl34 228 10 50 50 CD cord-303447-3a7jxl34 228 11 lesions lesion NNS cord-303447-3a7jxl34 228 12 and and CC cord-303447-3a7jxl34 228 13 complications complication NNS cord-303447-3a7jxl34 228 14 requiring require VBG cord-303447-3a7jxl34 228 15 a a DT cord-303447-3a7jxl34 228 16 visit visit NN cord-303447-3a7jxl34 228 17 to to IN cord-303447-3a7jxl34 228 18 a a DT cord-303447-3a7jxl34 228 19 clinician clinician NN cord-303447-3a7jxl34 228 20 ) ) -RRB- cord-303447-3a7jxl34 228 21 was be VBD cord-303447-3a7jxl34 228 22 92 92 CD cord-303447-3a7jxl34 228 23 % % NN cord-303447-3a7jxl34 228 24 [ [ -LRB- cord-303447-3a7jxl34 228 25 69 69 CD cord-303447-3a7jxl34 228 26 ] ] -RRB- cord-303447-3a7jxl34 228 27 . . . cord-303447-3a7jxl34 229 1 A a DT cord-303447-3a7jxl34 229 2 second second JJ cord-303447-3a7jxl34 229 3 dose dose NN cord-303447-3a7jxl34 229 4 of of IN cord-303447-3a7jxl34 229 5 varicella varicella NN cord-303447-3a7jxl34 229 6 vaccine vaccine NN cord-303447-3a7jxl34 229 7 has have VBZ cord-303447-3a7jxl34 229 8 been be VBN cord-303447-3a7jxl34 229 9 approved approve VBN cord-303447-3a7jxl34 229 10 by by IN cord-303447-3a7jxl34 229 11 the the DT cord-303447-3a7jxl34 229 12 FDA FDA NNP cord-303447-3a7jxl34 229 13 and and CC cord-303447-3a7jxl34 229 14 is be VBZ cord-303447-3a7jxl34 229 15 being be VBG cord-303447-3a7jxl34 229 16 considered consider VBN cord-303447-3a7jxl34 229 17 for for IN cord-303447-3a7jxl34 229 18 the the DT cord-303447-3a7jxl34 229 19 routine routine JJ cord-303447-3a7jxl34 229 20 childhood childhood NN cord-303447-3a7jxl34 229 21 vaccination vaccination NN cord-303447-3a7jxl34 229 22 schedule schedule NN cord-303447-3a7jxl34 229 23 . . . cord-303447-3a7jxl34 230 1 The the DT cord-303447-3a7jxl34 230 2 impact impact NN cord-303447-3a7jxl34 230 3 of of IN cord-303447-3a7jxl34 230 4 varicella varicella NN cord-303447-3a7jxl34 230 5 vaccine vaccine NN cord-303447-3a7jxl34 230 6 on on IN cord-303447-3a7jxl34 230 7 the the DT cord-303447-3a7jxl34 230 8 incidence incidence NN cord-303447-3a7jxl34 230 9 of of IN cord-303447-3a7jxl34 230 10 zoster zoster NN cord-303447-3a7jxl34 230 11 infections infection NNS cord-303447-3a7jxl34 230 12 in in IN cord-303447-3a7jxl34 230 13 adults adult NNS cord-303447-3a7jxl34 230 14 in in IN cord-303447-3a7jxl34 230 15 the the DT cord-303447-3a7jxl34 230 16 United United NNP cord-303447-3a7jxl34 230 17 States States NNP cord-303447-3a7jxl34 230 18 is be VBZ cord-303447-3a7jxl34 230 19 unknown unknown JJ cord-303447-3a7jxl34 230 20 . . . cord-303447-3a7jxl34 231 1 Varicella varicella NN cord-303447-3a7jxl34 231 2 vaccine vaccine NN cord-303447-3a7jxl34 231 3 may may MD cord-303447-3a7jxl34 231 4 protect protect VB cord-303447-3a7jxl34 231 5 children child NNS cord-303447-3a7jxl34 231 6 receiving receive VBG cord-303447-3a7jxl34 231 7 the the DT cord-303447-3a7jxl34 231 8 vaccine vaccine NN cord-303447-3a7jxl34 231 9 from from IN cord-303447-3a7jxl34 231 10 zoster zoster NNP cord-303447-3a7jxl34 231 11 when when WRB cord-303447-3a7jxl34 231 12 they -PRON- PRP cord-303447-3a7jxl34 231 13 become become VBP cord-303447-3a7jxl34 231 14 adults adult NNS cord-303447-3a7jxl34 231 15 . . . cord-303447-3a7jxl34 232 1 Studies study NNS cord-303447-3a7jxl34 232 2 suggest suggest VBP cord-303447-3a7jxl34 232 3 , , , cord-303447-3a7jxl34 232 4 however however RB cord-303447-3a7jxl34 232 5 , , , cord-303447-3a7jxl34 232 6 that that IN cord-303447-3a7jxl34 232 7 continued continue VBD cord-303447-3a7jxl34 232 8 exposure exposure NN cord-303447-3a7jxl34 232 9 to to IN cord-303447-3a7jxl34 232 10 varicella varicella NN cord-303447-3a7jxl34 232 11 protects protect VBZ cord-303447-3a7jxl34 232 12 latently latently RB cord-303447-3a7jxl34 232 13 infected infect VBN cord-303447-3a7jxl34 232 14 adults adult NNS cord-303447-3a7jxl34 232 15 [ [ -LRB- cord-303447-3a7jxl34 232 16 70 70 CD cord-303447-3a7jxl34 232 17 ] ] -RRB- cord-303447-3a7jxl34 232 18 . . . cord-303447-3a7jxl34 233 1 Vaccination vaccination NN cord-303447-3a7jxl34 233 2 in in IN cord-303447-3a7jxl34 233 3 children child NNS cord-303447-3a7jxl34 233 4 could could MD cord-303447-3a7jxl34 233 5 lead lead VB cord-303447-3a7jxl34 233 6 to to IN cord-303447-3a7jxl34 233 7 an an DT cord-303447-3a7jxl34 233 8 increase increase NN cord-303447-3a7jxl34 233 9 in in IN cord-303447-3a7jxl34 233 10 zoster zoster NN cord-303447-3a7jxl34 233 11 incidence incidence NN cord-303447-3a7jxl34 233 12 in in IN cord-303447-3a7jxl34 233 13 unvaccinated unvaccinated JJ cord-303447-3a7jxl34 233 14 adults adult NNS cord-303447-3a7jxl34 233 15 because because IN cord-303447-3a7jxl34 233 16 exposure exposure NN cord-303447-3a7jxl34 233 17 to to IN cord-303447-3a7jxl34 233 18 varicella varicella NN cord-303447-3a7jxl34 233 19 - - HYPH cord-303447-3a7jxl34 233 20 infected infect VBN cord-303447-3a7jxl34 233 21 children child NNS cord-303447-3a7jxl34 233 22 has have VBZ cord-303447-3a7jxl34 233 23 declined decline VBN cord-303447-3a7jxl34 233 24 , , , cord-303447-3a7jxl34 233 25 but but CC cord-303447-3a7jxl34 233 26 zoster zoster NN cord-303447-3a7jxl34 233 27 surveillance surveillance NN cord-303447-3a7jxl34 233 28 is be VBZ cord-303447-3a7jxl34 233 29 limited limit VBN cord-303447-3a7jxl34 233 30 . . . cord-303447-3a7jxl34 234 1 A a DT cord-303447-3a7jxl34 234 2 vaccine vaccine NN cord-303447-3a7jxl34 234 3 to to TO cord-303447-3a7jxl34 234 4 prevent prevent VB cord-303447-3a7jxl34 234 5 herpes herpes NN cord-303447-3a7jxl34 234 6 zoster zoster NN cord-303447-3a7jxl34 234 7 in in IN cord-303447-3a7jxl34 234 8 adults adult NNS cord-303447-3a7jxl34 234 9 is be VBZ cord-303447-3a7jxl34 234 10 under under IN cord-303447-3a7jxl34 234 11 investigation investigation NN cord-303447-3a7jxl34 234 12 . . . cord-303447-3a7jxl34 235 1 Since since IN cord-303447-3a7jxl34 235 2 the the DT cord-303447-3a7jxl34 235 3 worldwide worldwide JJ cord-303447-3a7jxl34 235 4 influenza influenza NN cord-303447-3a7jxl34 235 5 pandemic pandemic NN cord-303447-3a7jxl34 235 6 of of IN cord-303447-3a7jxl34 235 7 1918 1918 CD cord-303447-3a7jxl34 235 8 that that WDT cord-303447-3a7jxl34 235 9 caused cause VBD cord-303447-3a7jxl34 235 10 an an DT cord-303447-3a7jxl34 235 11 estimated estimate VBN cord-303447-3a7jxl34 235 12 25 25 CD cord-303447-3a7jxl34 235 13 to to TO cord-303447-3a7jxl34 235 14 50 50 CD cord-303447-3a7jxl34 235 15 million million CD cord-303447-3a7jxl34 235 16 deaths death NNS cord-303447-3a7jxl34 235 17 , , , cord-303447-3a7jxl34 235 18 the the DT cord-303447-3a7jxl34 235 19 control control NN cord-303447-3a7jxl34 235 20 of of IN cord-303447-3a7jxl34 235 21 influenza influenza NN cord-303447-3a7jxl34 235 22 circulation circulation NN cord-303447-3a7jxl34 235 23 has have VBZ cord-303447-3a7jxl34 235 24 been be VBN cord-303447-3a7jxl34 235 25 a a DT cord-303447-3a7jxl34 235 26 major major JJ cord-303447-3a7jxl34 235 27 challenge challenge NN cord-303447-3a7jxl34 235 28 to to IN cord-303447-3a7jxl34 235 29 clinicians clinician NNS cord-303447-3a7jxl34 235 30 and and CC cord-303447-3a7jxl34 235 31 public public JJ cord-303447-3a7jxl34 235 32 health health NN cord-303447-3a7jxl34 235 33 experts expert NNS cord-303447-3a7jxl34 235 34 . . . cord-303447-3a7jxl34 236 1 The the DT cord-303447-3a7jxl34 236 2 threat threat NN cord-303447-3a7jxl34 236 3 of of IN cord-303447-3a7jxl34 236 4 an an DT cord-303447-3a7jxl34 236 5 unpredictable unpredictable JJ cord-303447-3a7jxl34 236 6 influenza influenza NN cord-303447-3a7jxl34 236 7 pandemic pandemic NN cord-303447-3a7jxl34 236 8 and and CC cord-303447-3a7jxl34 236 9 the the DT cord-303447-3a7jxl34 236 10 concern concern NN cord-303447-3a7jxl34 236 11 about about IN cord-303447-3a7jxl34 236 12 avian avian JJ cord-303447-3a7jxl34 236 13 influenza influenza NN cord-303447-3a7jxl34 236 14 heighten heighten VB cord-303447-3a7jxl34 236 15 the the DT cord-303447-3a7jxl34 236 16 importance importance NN cord-303447-3a7jxl34 236 17 of of IN cord-303447-3a7jxl34 236 18 preventing prevent VBG cord-303447-3a7jxl34 236 19 morbidity morbidity NN cord-303447-3a7jxl34 236 20 and and CC cord-303447-3a7jxl34 236 21 mortality mortality NN cord-303447-3a7jxl34 236 22 caused cause VBN cord-303447-3a7jxl34 236 23 by by IN cord-303447-3a7jxl34 236 24 epidemics epidemic NNS cord-303447-3a7jxl34 236 25 of of IN cord-303447-3a7jxl34 236 26 influenza influenza NN cord-303447-3a7jxl34 236 27 disease disease NN cord-303447-3a7jxl34 236 28 in in IN cord-303447-3a7jxl34 236 29 the the DT cord-303447-3a7jxl34 236 30 United United NNP cord-303447-3a7jxl34 236 31 States States NNP cord-303447-3a7jxl34 236 32 , , , cord-303447-3a7jxl34 236 33 which which WDT cord-303447-3a7jxl34 236 34 cause cause VBP cord-303447-3a7jxl34 236 35 more more JJR cord-303447-3a7jxl34 236 36 than than IN cord-303447-3a7jxl34 236 37 250,000 250,000 CD cord-303447-3a7jxl34 236 38 hospitalizations hospitalization NNS cord-303447-3a7jxl34 236 39 and and CC cord-303447-3a7jxl34 236 40 more more JJR cord-303447-3a7jxl34 236 41 than than IN cord-303447-3a7jxl34 236 42 36,000 36,000 CD cord-303447-3a7jxl34 236 43 deaths death NNS cord-303447-3a7jxl34 236 44 annually annually RB cord-303447-3a7jxl34 236 45 [ [ -LRB- cord-303447-3a7jxl34 236 46 71 71 CD cord-303447-3a7jxl34 236 47 ] ] -RRB- cord-303447-3a7jxl34 236 48 . . . cord-303447-3a7jxl34 237 1 Implementing implement VBG cord-303447-3a7jxl34 237 2 the the DT cord-303447-3a7jxl34 237 3 expansion expansion NN cord-303447-3a7jxl34 237 4 of of IN cord-303447-3a7jxl34 237 5 influenza influenza NN cord-303447-3a7jxl34 237 6 vaccine vaccine NN cord-303447-3a7jxl34 237 7 recommendations recommendation NNS cord-303447-3a7jxl34 237 8 to to IN cord-303447-3a7jxl34 237 9 6-to 6-to CD cord-303447-3a7jxl34 237 10 23-month 23-month JJ cord-303447-3a7jxl34 237 11 - - HYPH cord-303447-3a7jxl34 237 12 old old JJ cord-303447-3a7jxl34 237 13 children child NNS cord-303447-3a7jxl34 237 14 and and CC cord-303447-3a7jxl34 237 15 prioritizing prioritize VBG cord-303447-3a7jxl34 237 16 vaccine vaccine NN cord-303447-3a7jxl34 237 17 during during IN cord-303447-3a7jxl34 237 18 influenza influenza NN cord-303447-3a7jxl34 237 19 vaccine vaccine NN cord-303447-3a7jxl34 237 20 shortages shortage NNS cord-303447-3a7jxl34 237 21 are be VBP cord-303447-3a7jxl34 237 22 important important JJ cord-303447-3a7jxl34 237 23 issues issue NNS cord-303447-3a7jxl34 237 24 the the DT cord-303447-3a7jxl34 237 25 US US NNP cord-303447-3a7jxl34 237 26 immunization immunization NN cord-303447-3a7jxl34 237 27 program program NN cord-303447-3a7jxl34 237 28 faces face VBZ cord-303447-3a7jxl34 237 29 regarding regard VBG cord-303447-3a7jxl34 237 30 influenza influenza NN cord-303447-3a7jxl34 237 31 prevention prevention NN cord-303447-3a7jxl34 237 32 . . . cord-303447-3a7jxl34 238 1 Influenza influenza NN cord-303447-3a7jxl34 238 2 virus virus NN cord-303447-3a7jxl34 238 3 contains contain VBZ cord-303447-3a7jxl34 238 4 eight eight CD cord-303447-3a7jxl34 238 5 major major JJ cord-303447-3a7jxl34 238 6 proteins protein NNS cord-303447-3a7jxl34 238 7 , , , cord-303447-3a7jxl34 238 8 including include VBG cord-303447-3a7jxl34 238 9 hemagglutinin hemagglutinin NN cord-303447-3a7jxl34 238 10 ( ( -LRB- cord-303447-3a7jxl34 238 11 HA HA NNP cord-303447-3a7jxl34 238 12 ) ) -RRB- cord-303447-3a7jxl34 238 13 , , , cord-303447-3a7jxl34 238 14 which which WDT cord-303447-3a7jxl34 238 15 controls control VBZ cord-303447-3a7jxl34 238 16 viral viral JJ cord-303447-3a7jxl34 238 17 penetration penetration NN cord-303447-3a7jxl34 238 18 and and CC cord-303447-3a7jxl34 238 19 attachment attachment NN cord-303447-3a7jxl34 238 20 , , , cord-303447-3a7jxl34 238 21 and and CC cord-303447-3a7jxl34 238 22 neuraminidase neuraminidase NN cord-303447-3a7jxl34 238 23 ( ( -LRB- cord-303447-3a7jxl34 238 24 NA NA NNP cord-303447-3a7jxl34 238 25 ) ) -RRB- cord-303447-3a7jxl34 238 26 , , , cord-303447-3a7jxl34 238 27 which which WDT cord-303447-3a7jxl34 238 28 controls control VBZ cord-303447-3a7jxl34 238 29 viral viral JJ cord-303447-3a7jxl34 238 30 particle particle NN cord-303447-3a7jxl34 238 31 release release NN cord-303447-3a7jxl34 238 32 and and CC cord-303447-3a7jxl34 238 33 spread spread VB cord-303447-3a7jxl34 238 34 . . . cord-303447-3a7jxl34 239 1 Influenza influenza NN cord-303447-3a7jxl34 239 2 strains strain NNS cord-303447-3a7jxl34 239 3 are be VBP cord-303447-3a7jxl34 239 4 identified identify VBN cord-303447-3a7jxl34 239 5 by by IN cord-303447-3a7jxl34 239 6 type type NN cord-303447-3a7jxl34 239 7 ( ( -LRB- cord-303447-3a7jxl34 239 8 A A NNP cord-303447-3a7jxl34 239 9 , , , cord-303447-3a7jxl34 239 10 B b NN cord-303447-3a7jxl34 239 11 , , , cord-303447-3a7jxl34 239 12 and and CC cord-303447-3a7jxl34 239 13 C C NNP cord-303447-3a7jxl34 239 14 ) ) -RRB- cord-303447-3a7jxl34 239 15 and and CC cord-303447-3a7jxl34 239 16 by by IN cord-303447-3a7jxl34 239 17 subtype subtype NN cord-303447-3a7jxl34 239 18 categorized categorize VBN cord-303447-3a7jxl34 239 19 by by IN cord-303447-3a7jxl34 239 20 HA HA NNP cord-303447-3a7jxl34 239 21 and and CC cord-303447-3a7jxl34 239 22 NA NA NNP cord-303447-3a7jxl34 239 23 . . . cord-303447-3a7jxl34 240 1 There there EX cord-303447-3a7jxl34 240 2 are be VBP cord-303447-3a7jxl34 240 3 15 15 CD cord-303447-3a7jxl34 240 4 different different JJ cord-303447-3a7jxl34 240 5 HA HA NNP cord-303447-3a7jxl34 240 6 and and CC cord-303447-3a7jxl34 240 7 9 9 CD cord-303447-3a7jxl34 240 8 different different JJ cord-303447-3a7jxl34 240 9 NA NA NNP cord-303447-3a7jxl34 240 10 subtypes subtype NNS cord-303447-3a7jxl34 240 11 . . . cord-303447-3a7jxl34 241 1 Major major JJ cord-303447-3a7jxl34 241 2 changes change NNS cord-303447-3a7jxl34 241 3 in in IN cord-303447-3a7jxl34 241 4 HA HA NNP cord-303447-3a7jxl34 241 5 and and CC cord-303447-3a7jxl34 241 6 NA NA NNP cord-303447-3a7jxl34 241 7 , , , cord-303447-3a7jxl34 241 8 called call VBN cord-303447-3a7jxl34 241 9 antigenic antigenic JJ cord-303447-3a7jxl34 241 10 shifts shift NNS cord-303447-3a7jxl34 241 11 , , , cord-303447-3a7jxl34 241 12 are be VBP cord-303447-3a7jxl34 241 13 associated associate VBN cord-303447-3a7jxl34 241 14 with with IN cord-303447-3a7jxl34 241 15 emergence emergence NN cord-303447-3a7jxl34 241 16 of of IN cord-303447-3a7jxl34 241 17 novel novel JJ cord-303447-3a7jxl34 241 18 influenza influenza NN cord-303447-3a7jxl34 241 19 viruses virus NNS cord-303447-3a7jxl34 241 20 to to IN cord-303447-3a7jxl34 241 21 which which WDT cord-303447-3a7jxl34 241 22 little little JJ cord-303447-3a7jxl34 241 23 or or CC cord-303447-3a7jxl34 241 24 no no DT cord-303447-3a7jxl34 241 25 immunity immunity NN cord-303447-3a7jxl34 241 26 exists exist VBZ cord-303447-3a7jxl34 241 27 in in IN cord-303447-3a7jxl34 241 28 the the DT cord-303447-3a7jxl34 241 29 exposed expose VBN cord-303447-3a7jxl34 241 30 population population NN cord-303447-3a7jxl34 241 31 . . . cord-303447-3a7jxl34 242 1 Antigenic antigenic JJ cord-303447-3a7jxl34 242 2 shifts shift NNS cord-303447-3a7jxl34 242 3 were be VBD cord-303447-3a7jxl34 242 4 the the DT cord-303447-3a7jxl34 242 5 cause cause NN cord-303447-3a7jxl34 242 6 of of IN cord-303447-3a7jxl34 242 7 the the DT cord-303447-3a7jxl34 242 8 three three CD cord-303447-3a7jxl34 242 9 influenza influenza NN cord-303447-3a7jxl34 242 10 pandemics pandemic NNS cord-303447-3a7jxl34 242 11 in in IN cord-303447-3a7jxl34 242 12 the the DT cord-303447-3a7jxl34 242 13 twentieth twentieth JJ cord-303447-3a7jxl34 242 14 century century NN cord-303447-3a7jxl34 242 15 ( ( -LRB- cord-303447-3a7jxl34 242 16 Table Table NNP cord-303447-3a7jxl34 242 17 7 7 CD cord-303447-3a7jxl34 242 18 ) ) -RRB- cord-303447-3a7jxl34 242 19 [ [ -LRB- cord-303447-3a7jxl34 242 20 72 72 CD cord-303447-3a7jxl34 242 21 ] ] -RRB- cord-303447-3a7jxl34 242 22 . . . cord-303447-3a7jxl34 243 1 Minor minor JJ cord-303447-3a7jxl34 243 2 changes change NNS cord-303447-3a7jxl34 243 3 in in IN cord-303447-3a7jxl34 243 4 HA HA NNP cord-303447-3a7jxl34 243 5 and and CC cord-303447-3a7jxl34 243 6 NA NA NNP cord-303447-3a7jxl34 243 7 , , , cord-303447-3a7jxl34 243 8 called call VBN cord-303447-3a7jxl34 243 9 antigenic antigenic JJ cord-303447-3a7jxl34 243 10 drifts drift NNS cord-303447-3a7jxl34 243 11 , , , cord-303447-3a7jxl34 243 12 define define VB cord-303447-3a7jxl34 243 13 the the DT cord-303447-3a7jxl34 243 14 influenza influenza NN cord-303447-3a7jxl34 243 15 viruses virus NNS cord-303447-3a7jxl34 243 16 that that WDT cord-303447-3a7jxl34 243 17 circulate circulate VBP cord-303447-3a7jxl34 243 18 each each DT cord-303447-3a7jxl34 243 19 year year NN cord-303447-3a7jxl34 243 20 . . . cord-303447-3a7jxl34 244 1 Influenza influenza NN cord-303447-3a7jxl34 244 2 vaccines vaccine NNS cord-303447-3a7jxl34 244 3 are be VBP cord-303447-3a7jxl34 244 4 developed develop VBN cord-303447-3a7jxl34 244 5 yearly yearly RB cord-303447-3a7jxl34 244 6 based base VBN cord-303447-3a7jxl34 244 7 on on IN cord-303447-3a7jxl34 244 8 antigenic antigenic JJ cord-303447-3a7jxl34 244 9 drifts drift NNS cord-303447-3a7jxl34 244 10 . . . cord-303447-3a7jxl34 245 1 Worldwide worldwide JJ cord-303447-3a7jxl34 245 2 surveillance surveillance NN cord-303447-3a7jxl34 245 3 established establish VBN cord-303447-3a7jxl34 245 4 by by IN cord-303447-3a7jxl34 245 5 the the DT cord-303447-3a7jxl34 245 6 World World NNP cord-303447-3a7jxl34 245 7 Health Health NNP cord-303447-3a7jxl34 245 8 Organization Organization NNP cord-303447-3a7jxl34 245 9 allows allow VBZ cord-303447-3a7jxl34 245 10 predictions prediction NNS cord-303447-3a7jxl34 245 11 to to TO cord-303447-3a7jxl34 245 12 be be VB cord-303447-3a7jxl34 245 13 made make VBN cord-303447-3a7jxl34 245 14 regarding regard VBG cord-303447-3a7jxl34 245 15 antigenic antigenic JJ cord-303447-3a7jxl34 245 16 drifts drift NNS cord-303447-3a7jxl34 245 17 , , , cord-303447-3a7jxl34 245 18 which which WDT cord-303447-3a7jxl34 245 19 enables enable VBZ cord-303447-3a7jxl34 245 20 vaccine vaccine NN cord-303447-3a7jxl34 245 21 to to TO cord-303447-3a7jxl34 245 22 be be VB cord-303447-3a7jxl34 245 23 updated update VBN cord-303447-3a7jxl34 245 24 before before IN cord-303447-3a7jxl34 245 25 the the DT cord-303447-3a7jxl34 245 26 start start NN cord-303447-3a7jxl34 245 27 of of IN cord-303447-3a7jxl34 245 28 an an DT cord-303447-3a7jxl34 245 29 influenza influenza NN cord-303447-3a7jxl34 245 30 season season NN cord-303447-3a7jxl34 245 31 . . . cord-303447-3a7jxl34 246 1 Recommendations recommendation NNS cord-303447-3a7jxl34 246 2 for for IN cord-303447-3a7jxl34 246 3 which which WDT cord-303447-3a7jxl34 246 4 influenza influenza NN cord-303447-3a7jxl34 246 5 strains strain NNS cord-303447-3a7jxl34 246 6 should should MD cord-303447-3a7jxl34 246 7 be be VB cord-303447-3a7jxl34 246 8 included include VBN cord-303447-3a7jxl34 246 9 in in IN cord-303447-3a7jxl34 246 10 the the DT cord-303447-3a7jxl34 246 11 vaccine vaccine NN cord-303447-3a7jxl34 246 12 are be VBP cord-303447-3a7jxl34 246 13 made make VBN cord-303447-3a7jxl34 246 14 in in IN cord-303447-3a7jxl34 246 15 early early JJ cord-303447-3a7jxl34 246 16 spring spring NN cord-303447-3a7jxl34 246 17 before before IN cord-303447-3a7jxl34 246 18 influenza influenza NN cord-303447-3a7jxl34 246 19 season season NN cord-303447-3a7jxl34 246 20 . . . cord-303447-3a7jxl34 247 1 Three three CD cord-303447-3a7jxl34 247 2 influenza influenza NN cord-303447-3a7jxl34 247 3 types type NNS cord-303447-3a7jxl34 247 4 are be VBP cord-303447-3a7jxl34 247 5 formulated formulate VBN cord-303447-3a7jxl34 247 6 and and CC cord-303447-3a7jxl34 247 7 combined combine VBN cord-303447-3a7jxl34 247 8 to to TO cord-303447-3a7jxl34 247 9 make make VB cord-303447-3a7jxl34 247 10 a a DT cord-303447-3a7jxl34 247 11 new new JJ cord-303447-3a7jxl34 247 12 trivalent trivalent JJ cord-303447-3a7jxl34 247 13 vaccine vaccine NN cord-303447-3a7jxl34 247 14 each each DT cord-303447-3a7jxl34 247 15 year year NN cord-303447-3a7jxl34 247 16 . . . cord-303447-3a7jxl34 248 1 Two two CD cord-303447-3a7jxl34 248 2 types type NNS cord-303447-3a7jxl34 248 3 of of IN cord-303447-3a7jxl34 248 4 influenza influenza NN cord-303447-3a7jxl34 248 5 vaccines vaccine NNS cord-303447-3a7jxl34 248 6 are be VBP cord-303447-3a7jxl34 248 7 licensed license VBN cord-303447-3a7jxl34 248 8 for for IN cord-303447-3a7jxl34 248 9 use use NN cord-303447-3a7jxl34 248 10 in in IN cord-303447-3a7jxl34 248 11 the the DT cord-303447-3a7jxl34 248 12 United United NNP cord-303447-3a7jxl34 248 13 States States NNP cord-303447-3a7jxl34 248 14 . . . cord-303447-3a7jxl34 249 1 One one CD cord-303447-3a7jxl34 249 2 is be VBZ cord-303447-3a7jxl34 249 3 an an DT cord-303447-3a7jxl34 249 4 inactivated inactivated JJ cord-303447-3a7jxl34 249 5 vaccine vaccine NN cord-303447-3a7jxl34 249 6 recommended recommend VBN cord-303447-3a7jxl34 249 7 for for IN cord-303447-3a7jxl34 249 8 persons person NNS cord-303447-3a7jxl34 249 9 6 6 CD cord-303447-3a7jxl34 249 10 months month NNS cord-303447-3a7jxl34 249 11 of of IN cord-303447-3a7jxl34 249 12 age age NN cord-303447-3a7jxl34 249 13 in in IN cord-303447-3a7jxl34 249 14 highrisk highrisk JJ cord-303447-3a7jxl34 249 15 groups group NNS cord-303447-3a7jxl34 249 16 and and CC cord-303447-3a7jxl34 249 17 their -PRON- PRP$ cord-303447-3a7jxl34 249 18 close close JJ cord-303447-3a7jxl34 249 19 contacts contact NNS cord-303447-3a7jxl34 249 20 . . . cord-303447-3a7jxl34 250 1 The the DT cord-303447-3a7jxl34 250 2 second second JJ cord-303447-3a7jxl34 250 3 is be VBZ cord-303447-3a7jxl34 250 4 a a DT cord-303447-3a7jxl34 250 5 cold cold NN cord-303447-3a7jxl34 250 6 adapted adapt VBN cord-303447-3a7jxl34 250 7 , , , cord-303447-3a7jxl34 250 8 live live VBP cord-303447-3a7jxl34 250 9 , , , cord-303447-3a7jxl34 250 10 nasally nasally RB cord-303447-3a7jxl34 250 11 administered administer VBN cord-303447-3a7jxl34 250 12 vaccine vaccine NN cord-303447-3a7jxl34 250 13 licensed license VBN cord-303447-3a7jxl34 250 14 for for IN cord-303447-3a7jxl34 250 15 healthy healthy JJ cord-303447-3a7jxl34 250 16 people people NNS cord-303447-3a7jxl34 250 17 5 5 CD cord-303447-3a7jxl34 250 18 to to TO cord-303447-3a7jxl34 250 19 49 49 CD cord-303447-3a7jxl34 250 20 years year NNS cord-303447-3a7jxl34 250 21 of of IN cord-303447-3a7jxl34 250 22 age age NN cord-303447-3a7jxl34 250 23 , , , cord-303447-3a7jxl34 250 24 including include VBG cord-303447-3a7jxl34 250 25 close close JJ cord-303447-3a7jxl34 250 26 contacts contact NNS cord-303447-3a7jxl34 250 27 of of IN cord-303447-3a7jxl34 250 28 high high JJ cord-303447-3a7jxl34 250 29 - - HYPH cord-303447-3a7jxl34 250 30 risk risk NN cord-303447-3a7jxl34 250 31 persons person NNS cord-303447-3a7jxl34 250 32 . . . cord-303447-3a7jxl34 251 1 The the DT cord-303447-3a7jxl34 251 2 ACIP ACIP NNP cord-303447-3a7jxl34 251 3 and and CC cord-303447-3a7jxl34 251 4 AAP AAP NNP cord-303447-3a7jxl34 251 5 recommended recommend VBD cord-303447-3a7jxl34 251 6 in in IN cord-303447-3a7jxl34 251 7 2004 2004 CD cord-303447-3a7jxl34 251 8 to to TO cord-303447-3a7jxl34 251 9 expand expand VB cord-303447-3a7jxl34 251 10 influenza influenza NN cord-303447-3a7jxl34 251 11 vaccine vaccine NN cord-303447-3a7jxl34 251 12 recommendations recommendation NNS cord-303447-3a7jxl34 251 13 to to TO cord-303447-3a7jxl34 251 14 include include VB cord-303447-3a7jxl34 251 15 all all DT cord-303447-3a7jxl34 251 16 children child NNS cord-303447-3a7jxl34 251 17 6 6 CD cord-303447-3a7jxl34 251 18 to to TO cord-303447-3a7jxl34 251 19 23 23 CD cord-303447-3a7jxl34 251 20 months month NNS cord-303447-3a7jxl34 251 21 old old JJ cord-303447-3a7jxl34 251 22 and and CC cord-303447-3a7jxl34 251 23 household household NN cord-303447-3a7jxl34 251 24 contacts contact NNS cord-303447-3a7jxl34 251 25 of of IN cord-303447-3a7jxl34 251 26 children child NNS cord-303447-3a7jxl34 251 27 up up IN cord-303447-3a7jxl34 251 28 to to TO cord-303447-3a7jxl34 251 29 23 23 CD cord-303447-3a7jxl34 251 30 months month NNS cord-303447-3a7jxl34 251 31 old old JJ cord-303447-3a7jxl34 251 32 as as RB cord-303447-3a7jxl34 251 33 well well RB cord-303447-3a7jxl34 251 34 as as IN cord-303447-3a7jxl34 251 35 to to TO cord-303447-3a7jxl34 251 36 continue continue VB cord-303447-3a7jxl34 251 37 immunization immunization NN cord-303447-3a7jxl34 251 38 of of IN cord-303447-3a7jxl34 251 39 all all DT cord-303447-3a7jxl34 251 40 children child NNS cord-303447-3a7jxl34 251 41 in in IN cord-303447-3a7jxl34 251 42 high high JJ cord-303447-3a7jxl34 251 43 - - HYPH cord-303447-3a7jxl34 251 44 risk risk NN cord-303447-3a7jxl34 251 45 groups group NNS cord-303447-3a7jxl34 251 46 . . . cord-303447-3a7jxl34 252 1 This this DT cord-303447-3a7jxl34 252 2 recommendation recommendation NN cord-303447-3a7jxl34 252 3 was be VBD cord-303447-3a7jxl34 252 4 made make VBN cord-303447-3a7jxl34 252 5 based base VBN cord-303447-3a7jxl34 252 6 on on IN cord-303447-3a7jxl34 252 7 epidemiologic epidemiologic JJ cord-303447-3a7jxl34 252 8 data datum NNS cord-303447-3a7jxl34 252 9 showing show VBG cord-303447-3a7jxl34 252 10 that that IN cord-303447-3a7jxl34 252 11 healthy healthy JJ cord-303447-3a7jxl34 252 12 children child NNS cord-303447-3a7jxl34 252 13 in in IN cord-303447-3a7jxl34 252 14 this this DT cord-303447-3a7jxl34 252 15 age age NN cord-303447-3a7jxl34 252 16 group group NN cord-303447-3a7jxl34 252 17 are be VBP cord-303447-3a7jxl34 252 18 at at IN cord-303447-3a7jxl34 252 19 high high JJ cord-303447-3a7jxl34 252 20 risk risk NN cord-303447-3a7jxl34 252 21 of of IN cord-303447-3a7jxl34 252 22 hospitalization hospitalization NN cord-303447-3a7jxl34 252 23 from from IN cord-303447-3a7jxl34 252 24 influenza influenza NN cord-303447-3a7jxl34 252 25 , , , cord-303447-3a7jxl34 252 26 and and CC cord-303447-3a7jxl34 252 27 that that IN cord-303447-3a7jxl34 252 28 deaths death NNS cord-303447-3a7jxl34 252 29 in in IN cord-303447-3a7jxl34 252 30 this this DT cord-303447-3a7jxl34 252 31 age age NN cord-303447-3a7jxl34 252 32 group group NN cord-303447-3a7jxl34 252 33 occur occur VBP cord-303447-3a7jxl34 252 34 [ [ -LRB- cord-303447-3a7jxl34 252 35 73 73 CD cord-303447-3a7jxl34 252 36 ] ] -RRB- cord-303447-3a7jxl34 252 37 [ [ -LRB- cord-303447-3a7jxl34 252 38 74 74 CD cord-303447-3a7jxl34 252 39 ] ] -RRB- cord-303447-3a7jxl34 252 40 [ [ -LRB- cord-303447-3a7jxl34 252 41 75 75 CD cord-303447-3a7jxl34 252 42 ] ] -RRB- cord-303447-3a7jxl34 252 43 [ [ -LRB- cord-303447-3a7jxl34 252 44 76 76 CD cord-303447-3a7jxl34 252 45 ] ] -RRB- cord-303447-3a7jxl34 252 46 . . . cord-303447-3a7jxl34 253 1 More More JJR cord-303447-3a7jxl34 253 2 than than IN cord-303447-3a7jxl34 253 3 150 150 CD cord-303447-3a7jxl34 253 4 reports report NNS cord-303447-3a7jxl34 253 5 of of IN cord-303447-3a7jxl34 253 6 pediatric pediatric JJ cord-303447-3a7jxl34 253 7 influenzaassociated influenzaassociate VBN cord-303447-3a7jxl34 253 8 deaths death NNS cord-303447-3a7jxl34 253 9 during during IN cord-303447-3a7jxl34 253 10 the the DT cord-303447-3a7jxl34 253 11 2003 2003 CD cord-303447-3a7jxl34 253 12 - - SYM cord-303447-3a7jxl34 253 13 04 04 CD cord-303447-3a7jxl34 253 14 influenza influenza NN cord-303447-3a7jxl34 253 15 season season NN cord-303447-3a7jxl34 253 16 stimulated stimulate VBD cord-303447-3a7jxl34 253 17 the the DT cord-303447-3a7jxl34 253 18 addition addition NN cord-303447-3a7jxl34 253 19 [ [ -LRB- cord-303447-3a7jxl34 253 20 77 77 CD cord-303447-3a7jxl34 253 21 ] ] -RRB- cord-303447-3a7jxl34 253 22 . . . cord-303447-3a7jxl34 254 1 The the DT cord-303447-3a7jxl34 254 2 influenza influenza NN cord-303447-3a7jxl34 254 3 vaccine vaccine NN cord-303447-3a7jxl34 254 4 is be VBZ cord-303447-3a7jxl34 254 5 unique unique JJ cord-303447-3a7jxl34 254 6 to to IN cord-303447-3a7jxl34 254 7 the the DT cord-303447-3a7jxl34 254 8 recommended recommend VBN cord-303447-3a7jxl34 254 9 childhood childhood NN cord-303447-3a7jxl34 254 10 and and CC cord-303447-3a7jxl34 254 11 adolescent adolescent JJ cord-303447-3a7jxl34 254 12 immunization immunization NN cord-303447-3a7jxl34 254 13 schedule schedule NN cord-303447-3a7jxl34 254 14 because because IN cord-303447-3a7jxl34 254 15 it -PRON- PRP cord-303447-3a7jxl34 254 16 is be VBZ cord-303447-3a7jxl34 254 17 the the DT cord-303447-3a7jxl34 254 18 only only JJ cord-303447-3a7jxl34 254 19 vaccine vaccine NN cord-303447-3a7jxl34 254 20 that that WDT cord-303447-3a7jxl34 254 21 requires require VBZ cord-303447-3a7jxl34 254 22 a a DT cord-303447-3a7jxl34 254 23 visit visit NN cord-303447-3a7jxl34 254 24 during during IN cord-303447-3a7jxl34 254 25 a a DT cord-303447-3a7jxl34 254 26 certain certain JJ cord-303447-3a7jxl34 254 27 time time NN cord-303447-3a7jxl34 254 28 of of IN cord-303447-3a7jxl34 254 29 year year NN cord-303447-3a7jxl34 254 30 and and CC cord-303447-3a7jxl34 254 31 that that DT cord-303447-3a7jxl34 254 32 requires require VBZ cord-303447-3a7jxl34 254 33 annual annual JJ cord-303447-3a7jxl34 254 34 immunization immunization NN cord-303447-3a7jxl34 254 35 . . . cord-303447-3a7jxl34 255 1 Even even RB cord-303447-3a7jxl34 255 2 if if IN cord-303447-3a7jxl34 255 3 the the DT cord-303447-3a7jxl34 255 4 circulating circulate VBG cord-303447-3a7jxl34 255 5 strains strain NNS cord-303447-3a7jxl34 255 6 of of IN cord-303447-3a7jxl34 255 7 virus virus NN cord-303447-3a7jxl34 255 8 are be VBP cord-303447-3a7jxl34 255 9 the the DT cord-303447-3a7jxl34 255 10 same same JJ cord-303447-3a7jxl34 255 11 as as IN cord-303447-3a7jxl34 255 12 the the DT cord-303447-3a7jxl34 255 13 year year NN cord-303447-3a7jxl34 255 14 before before RB cord-303447-3a7jxl34 255 15 , , , cord-303447-3a7jxl34 255 16 an an DT cord-303447-3a7jxl34 255 17 annual annual JJ cord-303447-3a7jxl34 255 18 booster booster NN cord-303447-3a7jxl34 255 19 is be VBZ cord-303447-3a7jxl34 255 20 necessary necessary JJ cord-303447-3a7jxl34 255 21 to to TO cord-303447-3a7jxl34 255 22 retain retain VB cord-303447-3a7jxl34 255 23 immunity immunity NN cord-303447-3a7jxl34 255 24 . . . cord-303447-3a7jxl34 256 1 In in IN cord-303447-3a7jxl34 256 2 addition addition NN cord-303447-3a7jxl34 256 3 , , , cord-303447-3a7jxl34 256 4 children child NNS cord-303447-3a7jxl34 256 5 6 6 CD cord-303447-3a7jxl34 256 6 months month NNS cord-303447-3a7jxl34 256 7 to to IN cord-303447-3a7jxl34 256 8 8 8 CD cord-303447-3a7jxl34 256 9 years year NNS cord-303447-3a7jxl34 256 10 old old JJ cord-303447-3a7jxl34 256 11 are be VBP cord-303447-3a7jxl34 256 12 recommended recommend VBN cord-303447-3a7jxl34 256 13 to to TO cord-303447-3a7jxl34 256 14 have have VB cord-303447-3a7jxl34 256 15 two two CD cord-303447-3a7jxl34 256 16 doses dose NNS cord-303447-3a7jxl34 256 17 of of IN cord-303447-3a7jxl34 256 18 influenza influenza NN cord-303447-3a7jxl34 256 19 vaccine vaccine NN cord-303447-3a7jxl34 256 20 administered administer VBD cord-303447-3a7jxl34 256 21 1 1 CD cord-303447-3a7jxl34 256 22 month month NN cord-303447-3a7jxl34 256 23 apart apart RB cord-303447-3a7jxl34 256 24 if if IN cord-303447-3a7jxl34 256 25 they -PRON- PRP cord-303447-3a7jxl34 256 26 previously previously RB cord-303447-3a7jxl34 256 27 have have VBP cord-303447-3a7jxl34 256 28 never never RB cord-303447-3a7jxl34 256 29 been be VBN cord-303447-3a7jxl34 256 30 vaccinated vaccinate VBN cord-303447-3a7jxl34 256 31 for for IN cord-303447-3a7jxl34 256 32 influenza influenza NN cord-303447-3a7jxl34 256 33 [ [ -LRB- cord-303447-3a7jxl34 256 34 76 76 CD cord-303447-3a7jxl34 256 35 ] ] -RRB- cord-303447-3a7jxl34 256 36 . . . cord-303447-3a7jxl34 257 1 Adding add VBG cord-303447-3a7jxl34 257 2 influenza influenza NN cord-303447-3a7jxl34 257 3 into into IN cord-303447-3a7jxl34 257 4 the the DT cord-303447-3a7jxl34 257 5 childhood childhood NN cord-303447-3a7jxl34 257 6 schedule schedule NN cord-303447-3a7jxl34 257 7 is be VBZ cord-303447-3a7jxl34 257 8 challenging challenging JJ cord-303447-3a7jxl34 257 9 for for IN cord-303447-3a7jxl34 257 10 public public JJ cord-303447-3a7jxl34 257 11 health health NN cord-303447-3a7jxl34 257 12 officials official NNS cord-303447-3a7jxl34 257 13 and and CC cord-303447-3a7jxl34 257 14 primary primary JJ cord-303447-3a7jxl34 257 15 care care NN cord-303447-3a7jxl34 257 16 physicians physician NNS cord-303447-3a7jxl34 257 17 developing develop VBG cord-303447-3a7jxl34 257 18 programs program NNS cord-303447-3a7jxl34 257 19 to to TO cord-303447-3a7jxl34 257 20 attain attain VB cord-303447-3a7jxl34 257 21 high high JJ cord-303447-3a7jxl34 257 22 coverage coverage NN cord-303447-3a7jxl34 257 23 rates rate NNS cord-303447-3a7jxl34 257 24 in in IN cord-303447-3a7jxl34 257 25 children child NNS cord-303447-3a7jxl34 257 26 6 6 CD cord-303447-3a7jxl34 257 27 to to TO cord-303447-3a7jxl34 257 28 23 23 CD cord-303447-3a7jxl34 257 29 months month NNS cord-303447-3a7jxl34 257 30 old old JJ cord-303447-3a7jxl34 257 31 . . . cord-303447-3a7jxl34 258 1 Vaccine vaccine NN cord-303447-3a7jxl34 258 2 development development NN cord-303447-3a7jxl34 258 3 is be VBZ cord-303447-3a7jxl34 258 4 expanding expand VBG cord-303447-3a7jxl34 258 5 to to TO cord-303447-3a7jxl34 258 6 include include VB cord-303447-3a7jxl34 258 7 products product NNS cord-303447-3a7jxl34 258 8 against against IN cord-303447-3a7jxl34 258 9 cancers cancer NNS cord-303447-3a7jxl34 258 10 , , , cord-303447-3a7jxl34 258 11 chronic chronic JJ cord-303447-3a7jxl34 258 12 diseases disease NNS cord-303447-3a7jxl34 258 13 , , , cord-303447-3a7jxl34 258 14 and and CC cord-303447-3a7jxl34 258 15 other other JJ cord-303447-3a7jxl34 258 16 infectious infectious JJ cord-303447-3a7jxl34 258 17 diseases disease NNS cord-303447-3a7jxl34 258 18 . . . cord-303447-3a7jxl34 259 1 Vaccines vaccine NNS cord-303447-3a7jxl34 259 2 against against IN cord-303447-3a7jxl34 259 3 inflammatory inflammatory JJ cord-303447-3a7jxl34 259 4 diseases disease NNS cord-303447-3a7jxl34 259 5 for for IN cord-303447-3a7jxl34 259 6 which which WDT cord-303447-3a7jxl34 259 7 an an DT cord-303447-3a7jxl34 259 8 infectious infectious JJ cord-303447-3a7jxl34 259 9 cause cause NN cord-303447-3a7jxl34 259 10 has have VBZ cord-303447-3a7jxl34 259 11 not not RB cord-303447-3a7jxl34 259 12 been be VBN cord-303447-3a7jxl34 259 13 identified identify VBN cord-303447-3a7jxl34 259 14 , , , cord-303447-3a7jxl34 259 15 such such JJ cord-303447-3a7jxl34 259 16 as as IN cord-303447-3a7jxl34 259 17 multiple multiple JJ cord-303447-3a7jxl34 259 18 sclerosis sclerosis NN cord-303447-3a7jxl34 259 19 and and CC cord-303447-3a7jxl34 259 20 rheumatoid rheumatoid NN cord-303447-3a7jxl34 259 21 arthritis arthritis NN cord-303447-3a7jxl34 259 22 , , , cord-303447-3a7jxl34 259 23 are be VBP cord-303447-3a7jxl34 259 24 being be VBG cord-303447-3a7jxl34 259 25 developed develop VBN cord-303447-3a7jxl34 259 26 as as IN cord-303447-3a7jxl34 259 27 therapeutic therapeutic JJ cord-303447-3a7jxl34 259 28 vaccines vaccine NNS cord-303447-3a7jxl34 259 29 . . . cord-303447-3a7jxl34 260 1 Scientists scientist NNS cord-303447-3a7jxl34 260 2 effectively effectively RB cord-303447-3a7jxl34 260 3 are be VBP cord-303447-3a7jxl34 260 4 using use VBG cord-303447-3a7jxl34 260 5 new new JJ cord-303447-3a7jxl34 260 6 biologic biologic JJ cord-303447-3a7jxl34 260 7 tools tool NNS cord-303447-3a7jxl34 260 8 to to TO cord-303447-3a7jxl34 260 9 improve improve VB cord-303447-3a7jxl34 260 10 existing exist VBG cord-303447-3a7jxl34 260 11 vaccines vaccine NNS cord-303447-3a7jxl34 260 12 . . . cord-303447-3a7jxl34 261 1 New new JJ cord-303447-3a7jxl34 261 2 technologies technology NNS cord-303447-3a7jxl34 261 3 also also RB cord-303447-3a7jxl34 261 4 are be VBP cord-303447-3a7jxl34 261 5 being be VBG cord-303447-3a7jxl34 261 6 used use VBN cord-303447-3a7jxl34 261 7 to to TO cord-303447-3a7jxl34 261 8 improve improve VB cord-303447-3a7jxl34 261 9 vaccine vaccine NN cord-303447-3a7jxl34 261 10 delivery delivery NN cord-303447-3a7jxl34 261 11 systems system NNS cord-303447-3a7jxl34 261 12 , , , cord-303447-3a7jxl34 261 13 producing produce VBG cord-303447-3a7jxl34 261 14 better well JJR cord-303447-3a7jxl34 261 15 combination combination NN cord-303447-3a7jxl34 261 16 , , , cord-303447-3a7jxl34 261 17 oral oral JJ cord-303447-3a7jxl34 261 18 , , , cord-303447-3a7jxl34 261 19 and and CC cord-303447-3a7jxl34 261 20 intranasal intranasal NN cord-303447-3a7jxl34 261 21 vaccines vaccine NNS cord-303447-3a7jxl34 261 22 . . . cord-303447-3a7jxl34 262 1 The the DT cord-303447-3a7jxl34 262 2 science science NN cord-303447-3a7jxl34 262 3 behind behind IN cord-303447-3a7jxl34 262 4 new new JJ cord-303447-3a7jxl34 262 5 vaccines vaccine NNS cord-303447-3a7jxl34 262 6 continues continue VBZ cord-303447-3a7jxl34 262 7 to to TO cord-303447-3a7jxl34 262 8 advance advance VB cord-303447-3a7jxl34 262 9 at at IN cord-303447-3a7jxl34 262 10 a a DT cord-303447-3a7jxl34 262 11 remarkable remarkable JJ cord-303447-3a7jxl34 262 12 pace pace NN cord-303447-3a7jxl34 262 13 , , , cord-303447-3a7jxl34 262 14 driven drive VBN cord-303447-3a7jxl34 262 15 by by IN cord-303447-3a7jxl34 262 16 an an DT cord-303447-3a7jxl34 262 17 evolving evolve VBG cord-303447-3a7jxl34 262 18 understanding understanding NN cord-303447-3a7jxl34 262 19 of of IN cord-303447-3a7jxl34 262 20 the the DT cord-303447-3a7jxl34 262 21 cellular cellular JJ cord-303447-3a7jxl34 262 22 and and CC cord-303447-3a7jxl34 262 23 molecular molecular JJ cord-303447-3a7jxl34 262 24 processes process NNS cord-303447-3a7jxl34 262 25 involved involve VBN cord-303447-3a7jxl34 262 26 in in IN cord-303447-3a7jxl34 262 27 different different JJ cord-303447-3a7jxl34 262 28 responses response NNS cord-303447-3a7jxl34 262 29 of of IN cord-303447-3a7jxl34 262 30 the the DT cord-303447-3a7jxl34 262 31 immune immune JJ cord-303447-3a7jxl34 262 32 system system NN cord-303447-3a7jxl34 262 33 [ [ -LRB- cord-303447-3a7jxl34 262 34 78 78 CD cord-303447-3a7jxl34 262 35 ] ] -RRB- cord-303447-3a7jxl34 262 36 . . . cord-303447-3a7jxl34 263 1 Many many JJ cord-303447-3a7jxl34 263 2 infectious infectious JJ cord-303447-3a7jxl34 263 3 organisms organism NNS cord-303447-3a7jxl34 263 4 have have VBP cord-303447-3a7jxl34 263 5 evolved evolve VBN cord-303447-3a7jxl34 263 6 over over IN cord-303447-3a7jxl34 263 7 thousands thousand NNS cord-303447-3a7jxl34 263 8 of of IN cord-303447-3a7jxl34 263 9 years year NNS cord-303447-3a7jxl34 263 10 to to TO cord-303447-3a7jxl34 263 11 evade evade VB cord-303447-3a7jxl34 263 12 this this DT cord-303447-3a7jxl34 263 13 immune immune JJ cord-303447-3a7jxl34 263 14 response response NN cord-303447-3a7jxl34 263 15 . . . cord-303447-3a7jxl34 264 1 Adjuvants adjuvant NNS cord-303447-3a7jxl34 264 2 to to IN cord-303447-3a7jxl34 264 3 vaccines vaccine NNS cord-303447-3a7jxl34 264 4 are be VBP cord-303447-3a7jxl34 264 5 now now RB cord-303447-3a7jxl34 264 6 being be VBG cord-303447-3a7jxl34 264 7 used use VBN cord-303447-3a7jxl34 264 8 not not RB cord-303447-3a7jxl34 264 9 only only RB cord-303447-3a7jxl34 264 10 to to TO cord-303447-3a7jxl34 264 11 create create VB cord-303447-3a7jxl34 264 12 an an DT cord-303447-3a7jxl34 264 13 immune immune JJ cord-303447-3a7jxl34 264 14 response response NN cord-303447-3a7jxl34 264 15 , , , cord-303447-3a7jxl34 264 16 but but CC cord-303447-3a7jxl34 264 17 also also RB cord-303447-3a7jxl34 264 18 to to TO cord-303447-3a7jxl34 264 19 focus focus VB cord-303447-3a7jxl34 264 20 the the DT cord-303447-3a7jxl34 264 21 immune immune JJ cord-303447-3a7jxl34 264 22 response response NN cord-303447-3a7jxl34 264 23 down down IN cord-303447-3a7jxl34 264 24 a a DT cord-303447-3a7jxl34 264 25 desired desire VBN cord-303447-3a7jxl34 264 26 path path NN cord-303447-3a7jxl34 264 27 [ [ -LRB- cord-303447-3a7jxl34 264 28 79 79 CD cord-303447-3a7jxl34 264 29 ] ] -RRB- cord-303447-3a7jxl34 264 30 . . . cord-303447-3a7jxl34 265 1 DNA DNA NNP cord-303447-3a7jxl34 265 2 vaccines vaccine NNS cord-303447-3a7jxl34 265 3 , , , cord-303447-3a7jxl34 265 4 plasmids plasmid NNS cord-303447-3a7jxl34 265 5 of of IN cord-303447-3a7jxl34 265 6 DNA dna NN cord-303447-3a7jxl34 265 7 encoding encode VBG cord-303447-3a7jxl34 265 8 the the DT cord-303447-3a7jxl34 265 9 desired desire VBN cord-303447-3a7jxl34 265 10 antigen antigen NN cord-303447-3a7jxl34 265 11 , , , cord-303447-3a7jxl34 265 12 also also RB cord-303447-3a7jxl34 265 13 are be VBP cord-303447-3a7jxl34 265 14 being be VBG cord-303447-3a7jxl34 265 15 developed develop VBN cord-303447-3a7jxl34 265 16 with with IN cord-303447-3a7jxl34 265 17 the the DT cord-303447-3a7jxl34 265 18 intention intention NN cord-303447-3a7jxl34 265 19 of of IN cord-303447-3a7jxl34 265 20 simplifying simplify VBG cord-303447-3a7jxl34 265 21 vaccine vaccine NN cord-303447-3a7jxl34 265 22 production production NN cord-303447-3a7jxl34 265 23 and and CC cord-303447-3a7jxl34 265 24 eliminating eliminate VBG cord-303447-3a7jxl34 265 25 the the DT cord-303447-3a7jxl34 265 26 possible possible JJ cord-303447-3a7jxl34 265 27 risk risk NN cord-303447-3a7jxl34 265 28 of of IN cord-303447-3a7jxl34 265 29 organism organism NN cord-303447-3a7jxl34 265 30 reversion reversion NN cord-303447-3a7jxl34 265 31 [ [ -LRB- cord-303447-3a7jxl34 265 32 78 78 CD cord-303447-3a7jxl34 265 33 ] ] -RRB- cord-303447-3a7jxl34 265 34 . . . cord-303447-3a7jxl34 266 1 As as IN cord-303447-3a7jxl34 266 2 was be VBD cord-303447-3a7jxl34 266 3 true true JJ cord-303447-3a7jxl34 266 4 during during IN cord-303447-3a7jxl34 266 5 the the DT cord-303447-3a7jxl34 266 6 time time NN cord-303447-3a7jxl34 266 7 of of IN cord-303447-3a7jxl34 266 8 Jenner Jenner NNP cord-303447-3a7jxl34 266 9 , , , cord-303447-3a7jxl34 266 10 vaccines vaccine NNS cord-303447-3a7jxl34 266 11 continue continue VBP cord-303447-3a7jxl34 266 12 to to TO cord-303447-3a7jxl34 266 13 push push VB cord-303447-3a7jxl34 266 14 the the DT cord-303447-3a7jxl34 266 15 frontiers frontier NNS cord-303447-3a7jxl34 266 16 of of IN cord-303447-3a7jxl34 266 17 science science NN cord-303447-3a7jxl34 266 18 and and CC cord-303447-3a7jxl34 266 19 medicine medicine NN cord-303447-3a7jxl34 266 20 . . . cord-303447-3a7jxl34 267 1 In in IN cord-303447-3a7jxl34 267 2 2000 2000 CD cord-303447-3a7jxl34 267 3 , , , cord-303447-3a7jxl34 267 4 the the DT cord-303447-3a7jxl34 267 5 IOM IOM NNP cord-303447-3a7jxl34 267 6 published publish VBD cord-303447-3a7jxl34 267 7 a a DT cord-303447-3a7jxl34 267 8 report report NN cord-303447-3a7jxl34 267 9 prioritizing prioritize VBG cord-303447-3a7jxl34 267 10 development development NN cord-303447-3a7jxl34 267 11 of of IN cord-303447-3a7jxl34 267 12 vaccines vaccine NNS cord-303447-3a7jxl34 267 13 to to TO cord-303447-3a7jxl34 267 14 be be VB cord-303447-3a7jxl34 267 15 used use VBN cord-303447-3a7jxl34 267 16 in in IN cord-303447-3a7jxl34 267 17 the the DT cord-303447-3a7jxl34 267 18 United United NNP cord-303447-3a7jxl34 267 19 States States NNP cord-303447-3a7jxl34 267 20 . . . cord-303447-3a7jxl34 268 1 The the DT cord-303447-3a7jxl34 268 2 IOM IOM NNP cord-303447-3a7jxl34 268 3 committee committee NN cord-303447-3a7jxl34 268 4 considered consider VBD cord-303447-3a7jxl34 268 5 vaccines vaccine NNS cord-303447-3a7jxl34 268 6 that that WDT cord-303447-3a7jxl34 268 7 could could MD cord-303447-3a7jxl34 268 8 be be VB cord-303447-3a7jxl34 268 9 licensed license VBN cord-303447-3a7jxl34 268 10 within within IN cord-303447-3a7jxl34 268 11 20 20 CD cord-303447-3a7jxl34 268 12 years year NNS cord-303447-3a7jxl34 268 13 directed direct VBN cord-303447-3a7jxl34 268 14 against against IN cord-303447-3a7jxl34 268 15 conditions condition NNS cord-303447-3a7jxl34 268 16 of of IN cord-303447-3a7jxl34 268 17 domestic domestic JJ cord-303447-3a7jxl34 268 18 health health NN cord-303447-3a7jxl34 268 19 importance importance NN cord-303447-3a7jxl34 268 20 [ [ -LRB- cord-303447-3a7jxl34 268 21 80 80 CD cord-303447-3a7jxl34 268 22 ] ] -RRB- cord-303447-3a7jxl34 268 23 . . . cord-303447-3a7jxl34 269 1 Health health NN cord-303447-3a7jxl34 269 2 benefits benefit NNS cord-303447-3a7jxl34 269 3 of of IN cord-303447-3a7jxl34 269 4 these these DT cord-303447-3a7jxl34 269 5 vaccines vaccine NNS cord-303447-3a7jxl34 269 6 were be VBD cord-303447-3a7jxl34 269 7 measured measure VBN cord-303447-3a7jxl34 269 8 by by IN cord-303447-3a7jxl34 269 9 a a DT cord-303447-3a7jxl34 269 10 standard standard JJ cord-303447-3a7jxl34 269 11 health health NN cord-303447-3a7jxl34 269 12 outcome outcome NN cord-303447-3a7jxl34 269 13 measure measure NN cord-303447-3a7jxl34 269 14 , , , cord-303447-3a7jxl34 269 15 quality quality NN cord-303447-3a7jxl34 269 16 - - HYPH cord-303447-3a7jxl34 269 17 adjusted adjust VBN cord-303447-3a7jxl34 269 18 life life NN cord-303447-3a7jxl34 269 19 years year NNS cord-303447-3a7jxl34 269 20 gained gain VBD cord-303447-3a7jxl34 269 21 . . . cord-303447-3a7jxl34 270 1 These these DT cord-303447-3a7jxl34 270 2 vaccines vaccine NNS cord-303447-3a7jxl34 270 3 were be VBD cord-303447-3a7jxl34 270 4 placed place VBN cord-303447-3a7jxl34 270 5 into into IN cord-303447-3a7jxl34 270 6 categories category NNS cord-303447-3a7jxl34 270 7 of of IN cord-303447-3a7jxl34 270 8 most most RBS cord-303447-3a7jxl34 270 9 favorable favorable JJ cord-303447-3a7jxl34 270 10 to to IN cord-303447-3a7jxl34 270 11 least least JJS cord-303447-3a7jxl34 270 12 favorable favorable JJ cord-303447-3a7jxl34 270 13 ( ( -LRB- cord-303447-3a7jxl34 270 14 Box Box NNP cord-303447-3a7jxl34 270 15 2 2 CD cord-303447-3a7jxl34 270 16 ) ) -RRB- cord-303447-3a7jxl34 270 17 . . . cord-303447-3a7jxl34 271 1 Since since IN cord-303447-3a7jxl34 271 2 publication publication NN cord-303447-3a7jxl34 271 3 of of IN cord-303447-3a7jxl34 271 4 this this DT cord-303447-3a7jxl34 271 5 report report NN cord-303447-3a7jxl34 271 6 , , , cord-303447-3a7jxl34 271 7 PCV7 PCV7 NNP cord-303447-3a7jxl34 271 8 has have VBZ cord-303447-3a7jxl34 271 9 been be VBN cord-303447-3a7jxl34 271 10 licensed license VBN cord-303447-3a7jxl34 271 11 for for IN cord-303447-3a7jxl34 271 12 infants infant NNS cord-303447-3a7jxl34 271 13 beginning begin VBG cord-303447-3a7jxl34 271 14 at at IN cord-303447-3a7jxl34 271 15 2 2 CD cord-303447-3a7jxl34 271 16 months month NNS cord-303447-3a7jxl34 271 17 of of IN cord-303447-3a7jxl34 271 18 age age NN cord-303447-3a7jxl34 271 19 ( ( -LRB- cord-303447-3a7jxl34 271 20 most most RBS cord-303447-3a7jxl34 271 21 favorable favorable JJ cord-303447-3a7jxl34 271 22 category category NN cord-303447-3a7jxl34 271 23 ) ) -RRB- cord-303447-3a7jxl34 271 24 , , , cord-303447-3a7jxl34 271 25 and and CC cord-303447-3a7jxl34 271 26 HPV HPV NNP cord-303447-3a7jxl34 271 27 vaccine vaccine NN cord-303447-3a7jxl34 271 28 ( ( -LRB- cord-303447-3a7jxl34 271 29 more more RBR cord-303447-3a7jxl34 271 30 favorable favorable JJ cord-303447-3a7jxl34 271 31 category category NN cord-303447-3a7jxl34 271 32 ) ) -RRB- cord-303447-3a7jxl34 271 33 and and CC cord-303447-3a7jxl34 271 34 rotavirus rotavirus JJ cord-303447-3a7jxl34 271 35 vaccine vaccine NN cord-303447-3a7jxl34 271 36 administered administer VBN cord-303447-3a7jxl34 271 37 to to IN cord-303447-3a7jxl34 271 38 infants infant NNS cord-303447-3a7jxl34 271 39 ( ( -LRB- cord-303447-3a7jxl34 271 40 favorable favorable JJ cord-303447-3a7jxl34 271 41 category category NN cord-303447-3a7jxl34 271 42 ) ) -RRB- cord-303447-3a7jxl34 271 43 are be VBP cord-303447-3a7jxl34 271 44 on on IN cord-303447-3a7jxl34 271 45 the the DT cord-303447-3a7jxl34 271 46 near near JJ cord-303447-3a7jxl34 271 47 horizon horizon NN cord-303447-3a7jxl34 271 48 as as IN cord-303447-3a7jxl34 271 49 discussed discuss VBN cord-303447-3a7jxl34 271 50 in in IN cord-303447-3a7jxl34 271 51 this this DT cord-303447-3a7jxl34 271 52 article article NN cord-303447-3a7jxl34 271 53 . . . cord-303447-3a7jxl34 272 1 Since since IN cord-303447-3a7jxl34 272 2 release release NN cord-303447-3a7jxl34 272 3 of of IN cord-303447-3a7jxl34 272 4 this this DT cord-303447-3a7jxl34 272 5 report report NN cord-303447-3a7jxl34 272 6 , , , cord-303447-3a7jxl34 272 7 several several JJ cord-303447-3a7jxl34 272 8 organisms organism NNS cord-303447-3a7jxl34 272 9 not not RB cord-303447-3a7jxl34 272 10 included include VBN cord-303447-3a7jxl34 272 11 on on IN cord-303447-3a7jxl34 272 12 the the DT cord-303447-3a7jxl34 272 13 IOM IOM NNP cord-303447-3a7jxl34 272 14 list list NN cord-303447-3a7jxl34 272 15 have have VBP cord-303447-3a7jxl34 272 16 emerged emerge VBN cord-303447-3a7jxl34 272 17 or or CC cord-303447-3a7jxl34 272 18 became become VBD cord-303447-3a7jxl34 272 19 larger large JJR cord-303447-3a7jxl34 272 20 public public JJ cord-303447-3a7jxl34 272 21 health health NN cord-303447-3a7jxl34 272 22 threats threat NNS cord-303447-3a7jxl34 272 23 , , , cord-303447-3a7jxl34 272 24 including include VBG cord-303447-3a7jxl34 272 25 West West NNP cord-303447-3a7jxl34 272 26 Nile Nile NNP cord-303447-3a7jxl34 272 27 virus virus NN cord-303447-3a7jxl34 272 28 , , , cord-303447-3a7jxl34 272 29 metapneumovirus metapneumovirus NNP cord-303447-3a7jxl34 272 30 , , , cord-303447-3a7jxl34 272 31 methicillin methicillin NN cord-303447-3a7jxl34 272 32 - - HYPH cord-303447-3a7jxl34 272 33 resistant resistant JJ cord-303447-3a7jxl34 272 34 Staphylococcus Staphylococcus NNP cord-303447-3a7jxl34 272 35 aureus aureus NN cord-303447-3a7jxl34 272 36 , , , cord-303447-3a7jxl34 272 37 the the DT cord-303447-3a7jxl34 272 38 coronavirus coronavirus NN cord-303447-3a7jxl34 272 39 associated associate VBN cord-303447-3a7jxl34 272 40 with with IN cord-303447-3a7jxl34 272 41 severe severe JJ cord-303447-3a7jxl34 272 42 acute acute JJ cord-303447-3a7jxl34 272 43 respiratory respiratory JJ cord-303447-3a7jxl34 272 44 syndrome syndrome NN cord-303447-3a7jxl34 272 45 Box Box NNP cord-303447-3a7jxl34 272 46 2 2 CD cord-303447-3a7jxl34 272 47 . . . cord-303447-3a7jxl34 273 1 Institute Institute NNP cord-303447-3a7jxl34 273 2 of of IN cord-303447-3a7jxl34 273 3 Medicine Medicine NNP cord-303447-3a7jxl34 273 4 report report VBP cord-303447-3a7jxl34 273 5 on on IN cord-303447-3a7jxl34 273 6 vaccines vaccine NNS cord-303447-3a7jxl34 273 7 for for IN cord-303447-3a7jxl34 273 8 the the DT cord-303447-3a7jxl34 273 9 twenty twenty CD cord-303447-3a7jxl34 273 10 - - HYPH cord-303447-3a7jxl34 273 11 first first JJ cord-303447-3a7jxl34 273 12 century century NN cord-303447-3a7jxl34 273 13 Most most RBS cord-303447-3a7jxl34 273 14 favorable favorable JJ cord-303447-3a7jxl34 273 15 : : : cord-303447-3a7jxl34 273 16 vaccination vaccination NN cord-303447-3a7jxl34 273 17 strategy strategy NN cord-303447-3a7jxl34 273 18 would would MD cord-303447-3a7jxl34 273 19 save save VB cord-303447-3a7jxl34 273 20 money money NN cord-303447-3a7jxl34 273 21 Cytomegalovirus Cytomegalovirus NNP cord-303447-3a7jxl34 273 22 vaccine vaccine NN cord-303447-3a7jxl34 273 23 administered administer VBN cord-303447-3a7jxl34 273 24 to to IN cord-303447-3a7jxl34 273 25 12-year 12-year JJ cord-303447-3a7jxl34 273 26 - - HYPH cord-303447-3a7jxl34 273 27 olds old NNS cord-303447-3a7jxl34 273 28 Influenza Influenza NNP cord-303447-3a7jxl34 273 29 virus virus NN cord-303447-3a7jxl34 273 30 vaccine vaccine NN cord-303447-3a7jxl34 273 31 administered administer VBN cord-303447-3a7jxl34 273 32 to to IN cord-303447-3a7jxl34 273 33 the the DT cord-303447-3a7jxl34 273 34 general general JJ cord-303447-3a7jxl34 273 35 population population NN cord-303447-3a7jxl34 273 36 ( ( -LRB- cord-303447-3a7jxl34 273 37 once once RB cord-303447-3a7jxl34 273 38 per per IN cord-303447-3a7jxl34 273 39 person person NN cord-303447-3a7jxl34 273 40 every every DT cord-303447-3a7jxl34 273 41 5 5 CD cord-303447-3a7jxl34 273 42 years year NNS cord-303447-3a7jxl34 273 43 ) ) -RRB- cord-303447-3a7jxl34 273 44 Insulin insulin NN cord-303447-3a7jxl34 273 45 - - HYPH cord-303447-3a7jxl34 273 46 dependent dependent JJ cord-303447-3a7jxl34 273 47 diabetes diabetes NN cord-303447-3a7jxl34 273 48 mellitus mellitus NN cord-303447-3a7jxl34 273 49 therapeutic therapeutic JJ cord-303447-3a7jxl34 273 50 vaccine vaccine NN cord-303447-3a7jxl34 273 51 Multiple multiple JJ cord-303447-3a7jxl34 273 52 sclerosis sclerosis NN cord-303447-3a7jxl34 273 53 therapeutic therapeutic JJ cord-303447-3a7jxl34 273 54 vaccine vaccine NN cord-303447-3a7jxl34 273 55 Rheumatoid Rheumatoid NNP cord-303447-3a7jxl34 273 56 arthritis arthritis NN cord-303447-3a7jxl34 273 57 therapeutic therapeutic JJ cord-303447-3a7jxl34 273 58 vaccine vaccine NN cord-303447-3a7jxl34 273 59 Group Group NNP cord-303447-3a7jxl34 273 60 B B NNP cord-303447-3a7jxl34 273 61 streptococcus streptococcus NN cord-303447-3a7jxl34 273 62 vaccine vaccine NN cord-303447-3a7jxl34 273 63 given give VBN cord-303447-3a7jxl34 273 64 to to IN cord-303447-3a7jxl34 273 65 women woman NNS cord-303447-3a7jxl34 273 66 during during IN cord-303447-3a7jxl34 273 67 first first JJ cord-303447-3a7jxl34 273 68 pregnancy pregnancy NN cord-303447-3a7jxl34 273 69 and and CC cord-303447-3a7jxl34 273 70 to to IN cord-303447-3a7jxl34 273 71 high high JJ cord-303447-3a7jxl34 273 72 - - HYPH cord-303447-3a7jxl34 273 73 risk risk NN cord-303447-3a7jxl34 273 74 adults adult NNS cord-303447-3a7jxl34 273 75 Streptococcus Streptococcus NNP cord-303447-3a7jxl34 273 76 pneumoniae pneumoniae NN cord-303447-3a7jxl34 273 77 vaccine vaccine NN cord-303447-3a7jxl34 273 78 given give VBN cord-303447-3a7jxl34 273 79 to to IN cord-303447-3a7jxl34 273 80 infants infant NNS cord-303447-3a7jxl34 273 81 and and CC cord-303447-3a7jxl34 273 82 65-year 65-year JJ cord-303447-3a7jxl34 273 83 - - HYPH cord-303447-3a7jxl34 273 84 olds old NNS cord-303447-3a7jxl34 273 85 More more RBR cord-303447-3a7jxl34 273 86 favorable favorable JJ cord-303447-3a7jxl34 273 87 : : : cord-303447-3a7jxl34 273 88 vaccination vaccination NN cord-303447-3a7jxl34 273 89 strategy strategy NN cord-303447-3a7jxl34 273 90 would would MD cord-303447-3a7jxl34 273 91 incur incur VB cord-303447-3a7jxl34 273 92 small small JJ cord-303447-3a7jxl34 273 93 costs cost NNS cord-303447-3a7jxl34 273 94 ( ( -LRB- cord-303447-3a7jxl34 273 95 b$10,000 b$10,000 NNP cord-303447-3a7jxl34 273 96 ) ) -RRB- cord-303447-3a7jxl34 273 97 for for IN cord-303447-3a7jxl34 273 98 each each DT cord-303447-3a7jxl34 273 99 QALY QALY NNP cord-303447-3a7jxl34 274 1 * * NFP cord-303447-3a7jxl34 274 2 Chlamydia Chlamydia NNP cord-303447-3a7jxl34 274 3 vaccine vaccine NN cord-303447-3a7jxl34 274 4 administered administer VBN cord-303447-3a7jxl34 274 5 to to IN cord-303447-3a7jxl34 274 6 12-year 12-year JJ cord-303447-3a7jxl34 274 7 - - HYPH cord-303447-3a7jxl34 274 8 olds old NNS cord-303447-3a7jxl34 274 9 Helicobacter Helicobacter NNP cord-303447-3a7jxl34 274 10 pylori pylori NN cord-303447-3a7jxl34 274 11 vaccine vaccine NN cord-303447-3a7jxl34 274 12 administered administer VBN cord-303447-3a7jxl34 274 13 to to IN cord-303447-3a7jxl34 274 14 infants infant NNS cord-303447-3a7jxl34 274 15 Hepatitis Hepatitis NNP cord-303447-3a7jxl34 274 16 C C NNP cord-303447-3a7jxl34 274 17 vaccine vaccine NN cord-303447-3a7jxl34 274 18 administered administer VBN cord-303447-3a7jxl34 274 19 to to IN cord-303447-3a7jxl34 274 20 infants infant NNS cord-303447-3a7jxl34 274 21 Herpes Herpes NNP cord-303447-3a7jxl34 274 22 simplex simplex NN cord-303447-3a7jxl34 274 23 virus virus NN cord-303447-3a7jxl34 274 24 vaccine vaccine NN cord-303447-3a7jxl34 274 25 administered administer VBN cord-303447-3a7jxl34 274 26 to to IN cord-303447-3a7jxl34 274 27 12-year 12-year JJ cord-303447-3a7jxl34 274 28 - - HYPH cord-303447-3a7jxl34 274 29 olds old NNS cord-303447-3a7jxl34 274 30 HPV HPV NNP cord-303447-3a7jxl34 274 31 vaccine vaccine NN cord-303447-3a7jxl34 274 32 administered administer VBD cord-303447-3a7jxl34 274 33 to to IN cord-303447-3a7jxl34 274 34 12-year 12-year JJ cord-303447-3a7jxl34 274 35 - - HYPH cord-303447-3a7jxl34 274 36 olds old NNS cord-303447-3a7jxl34 274 37 Melanoma Melanoma NNP cord-303447-3a7jxl34 274 38 therapeutic therapeutic JJ cord-303447-3a7jxl34 274 39 vaccine vaccine NN cord-303447-3a7jxl34 274 40 Mycobacterium Mycobacterium NNP cord-303447-3a7jxl34 274 41 tuberculosis tuberculosis NN cord-303447-3a7jxl34 274 42 vaccine vaccine NN cord-303447-3a7jxl34 274 43 administered administer VBN cord-303447-3a7jxl34 274 44 to to IN cord-303447-3a7jxl34 274 45 highrisk highrisk JJ cord-303447-3a7jxl34 274 46 populations population NNS cord-303447-3a7jxl34 274 47 Neisseria Neisseria NNP cord-303447-3a7jxl34 274 48 gonorrhoeae gonorrhoeae NNP cord-303447-3a7jxl34 274 49 vaccine vaccine NN cord-303447-3a7jxl34 274 50 administered administer VBN cord-303447-3a7jxl34 274 51 to to IN cord-303447-3a7jxl34 274 52 12-year 12-year JJ cord-303447-3a7jxl34 274 53 - - HYPH cord-303447-3a7jxl34 274 54 olds old NNS cord-303447-3a7jxl34 274 55 Respiratory respiratory JJ cord-303447-3a7jxl34 274 56 syncytial syncytial JJ cord-303447-3a7jxl34 274 57 virus virus NN cord-303447-3a7jxl34 274 58 vaccine vaccine NN cord-303447-3a7jxl34 274 59 administered administer VBN cord-303447-3a7jxl34 274 60 to to IN cord-303447-3a7jxl34 274 61 infants infant NNS cord-303447-3a7jxl34 274 62 and and CC cord-303447-3a7jxl34 274 63 12-year 12-year JJ cord-303447-3a7jxl34 274 64 - - HYPH cord-303447-3a7jxl34 274 65 olds old NNS cord-303447-3a7jxl34 275 1 Favorable favorable JJ cord-303447-3a7jxl34 275 2 : : : cord-303447-3a7jxl34 275 3 vaccination vaccination NN cord-303447-3a7jxl34 275 4 strategy strategy NN cord-303447-3a7jxl34 275 5 would would MD cord-303447-3a7jxl34 275 6 incur incur VB cord-303447-3a7jxl34 275 7 moderate moderate JJ cord-303447-3a7jxl34 275 8 costs cost NNS cord-303447-3a7jxl34 275 9 ( ( -LRB- cord-303447-3a7jxl34 275 10 N$10,000 n$10,000 NN cord-303447-3a7jxl34 275 11 but but CC cord-303447-3a7jxl34 275 12 b$100,000 b$100,000 CD cord-303447-3a7jxl34 275 13 ) ) -RRB- cord-303447-3a7jxl34 275 14 per per IN cord-303447-3a7jxl34 275 15 QALY QALY NNP cord-303447-3a7jxl34 275 16 gained gain VBD cord-303447-3a7jxl34 275 17 Parainfluenza Parainfluenza NNP cord-303447-3a7jxl34 275 18 virus virus NN cord-303447-3a7jxl34 275 19 vaccine vaccine NN cord-303447-3a7jxl34 275 20 administered administer VBN cord-303447-3a7jxl34 275 21 to to IN cord-303447-3a7jxl34 275 22 infants infant NNS cord-303447-3a7jxl34 275 23 and and CC cord-303447-3a7jxl34 275 24 women woman NNS cord-303447-3a7jxl34 275 25 during during IN cord-303447-3a7jxl34 275 26 their -PRON- PRP$ cord-303447-3a7jxl34 275 27 first first JJ cord-303447-3a7jxl34 275 28 pregnancy pregnancy NN cord-303447-3a7jxl34 275 29 Rotavirus Rotavirus NNP cord-303447-3a7jxl34 275 30 vaccine vaccine NN cord-303447-3a7jxl34 275 31 administered administer VBN cord-303447-3a7jxl34 275 32 to to IN cord-303447-3a7jxl34 275 33 infants infant NNS cord-303447-3a7jxl34 275 34 Group Group NNP cord-303447-3a7jxl34 275 35 A a DT cord-303447-3a7jxl34 275 36 streptococcus streptococcus NN cord-303447-3a7jxl34 275 37 vaccine vaccine NN cord-303447-3a7jxl34 275 38 administered administer VBN cord-303447-3a7jxl34 275 39 to to IN cord-303447-3a7jxl34 275 40 infants infant NNS cord-303447-3a7jxl34 275 41 Group Group NNP cord-303447-3a7jxl34 275 42 B B NNP cord-303447-3a7jxl34 275 43 streptococcus streptococcus NN cord-303447-3a7jxl34 275 44 vaccine vaccine NN cord-303447-3a7jxl34 275 45 given give VBN cord-303447-3a7jxl34 275 46 to to IN cord-303447-3a7jxl34 275 47 high high JJ cord-303447-3a7jxl34 275 48 - - HYPH cord-303447-3a7jxl34 275 49 risk risk NN cord-303447-3a7jxl34 275 50 adults adult NNS cord-303447-3a7jxl34 275 51 and and CC cord-303447-3a7jxl34 275 52 low low JJ cord-303447-3a7jxl34 275 53 utilization utilization NN cord-303447-3a7jxl34 275 54 in in IN cord-303447-3a7jxl34 275 55 12-year 12-year JJ cord-303447-3a7jxl34 275 56 - - HYPH cord-303447-3a7jxl34 275 57 olds old NNS cord-303447-3a7jxl34 275 58 or or CC cord-303447-3a7jxl34 275 59 women woman NNS cord-303447-3a7jxl34 275 60 during during IN cord-303447-3a7jxl34 275 61 their -PRON- PRP$ cord-303447-3a7jxl34 275 62 first first JJ cord-303447-3a7jxl34 275 63 pregnancy pregnancy NN cord-303447-3a7jxl34 275 64 ( ( -LRB- cord-303447-3a7jxl34 275 65 SARS SARS NNP cord-303447-3a7jxl34 275 66 ) ) -RRB- cord-303447-3a7jxl34 275 67 , , , cord-303447-3a7jxl34 275 68 and and CC cord-303447-3a7jxl34 275 69 avian avian JJ cord-303447-3a7jxl34 275 70 influenza influenza NN cord-303447-3a7jxl34 275 71 virus virus NN cord-303447-3a7jxl34 275 72 ( ( -LRB- cord-303447-3a7jxl34 275 73 H5N1 H5N1 NNP cord-303447-3a7jxl34 275 74 ) ) -RRB- cord-303447-3a7jxl34 275 75 . . . cord-303447-3a7jxl34 276 1 The the DT cord-303447-3a7jxl34 276 2 ongoing ongoing JJ cord-303447-3a7jxl34 276 3 outbreak outbreak NN cord-303447-3a7jxl34 276 4 of of IN cord-303447-3a7jxl34 276 5 H5N1 H5N1 NNP cord-303447-3a7jxl34 276 6 influenza influenza NN cord-303447-3a7jxl34 276 7 in in IN cord-303447-3a7jxl34 276 8 Asia Asia NNP cord-303447-3a7jxl34 276 9 , , , cord-303447-3a7jxl34 276 10 associated associate VBN cord-303447-3a7jxl34 276 11 with with IN cord-303447-3a7jxl34 276 12 high high JJ cord-303447-3a7jxl34 276 13 mortality mortality NN cord-303447-3a7jxl34 276 14 rates rate NNS cord-303447-3a7jxl34 276 15 , , , cord-303447-3a7jxl34 276 16 has have VBZ cord-303447-3a7jxl34 276 17 stimulated stimulate VBN cord-303447-3a7jxl34 276 18 research research NN cord-303447-3a7jxl34 276 19 of of IN cord-303447-3a7jxl34 276 20 a a DT cord-303447-3a7jxl34 276 21 vaccine vaccine NN cord-303447-3a7jxl34 276 22 that that WDT cord-303447-3a7jxl34 276 23 has have VBZ cord-303447-3a7jxl34 276 24 the the DT cord-303447-3a7jxl34 276 25 potential potential NN cord-303447-3a7jxl34 276 26 to to TO cord-303447-3a7jxl34 276 27 thwart thwart VB cord-303447-3a7jxl34 276 28 a a DT cord-303447-3a7jxl34 276 29 possible possible JJ cord-303447-3a7jxl34 276 30 major major JJ cord-303447-3a7jxl34 276 31 influenza influenza NN cord-303447-3a7jxl34 276 32 pandemic pandemic NN cord-303447-3a7jxl34 276 33 . . . cord-303447-3a7jxl34 277 1 Circulating circulate VBG cord-303447-3a7jxl34 277 2 H5N1 H5N1 NNP cord-303447-3a7jxl34 277 3 viruses virus NNS cord-303447-3a7jxl34 277 4 may may MD cord-303447-3a7jxl34 277 5 adapt adapt VB cord-303447-3a7jxl34 277 6 to to IN cord-303447-3a7jxl34 277 7 humans human NNS cord-303447-3a7jxl34 277 8 through through IN cord-303447-3a7jxl34 277 9 genetic genetic JJ cord-303447-3a7jxl34 277 10 mutation mutation NN cord-303447-3a7jxl34 277 11 or or CC cord-303447-3a7jxl34 277 12 reassortant reassortant JJ cord-303447-3a7jxl34 277 13 with with IN cord-303447-3a7jxl34 277 14 human human JJ cord-303447-3a7jxl34 277 15 influenza influenza NN cord-303447-3a7jxl34 277 16 strains strain NNS cord-303447-3a7jxl34 277 17 , , , cord-303447-3a7jxl34 277 18 allowing allow VBG cord-303447-3a7jxl34 277 19 for for IN cord-303447-3a7jxl34 277 20 human human NN cord-303447-3a7jxl34 277 21 - - HYPH cord-303447-3a7jxl34 277 22 to to IN cord-303447-3a7jxl34 277 23 - - HYPH cord-303447-3a7jxl34 277 24 human human JJ cord-303447-3a7jxl34 277 25 transmission transmission NN cord-303447-3a7jxl34 277 26 , , , cord-303447-3a7jxl34 277 27 facilitated facilitate VBN cord-303447-3a7jxl34 277 28 by by IN cord-303447-3a7jxl34 277 29 the the DT cord-303447-3a7jxl34 277 30 fact fact NN cord-303447-3a7jxl34 277 31 that that IN cord-303447-3a7jxl34 277 32 most most JJS cord-303447-3a7jxl34 277 33 humans human NNS cord-303447-3a7jxl34 277 34 lack lack VBP cord-303447-3a7jxl34 277 35 preexisting preexist VBG cord-303447-3a7jxl34 277 36 immunity immunity NN cord-303447-3a7jxl34 277 37 owing owe VBG cord-303447-3a7jxl34 277 38 to to IN cord-303447-3a7jxl34 277 39 lack lack NN cord-303447-3a7jxl34 277 40 of of IN cord-303447-3a7jxl34 277 41 previous previous JJ cord-303447-3a7jxl34 277 42 exposure exposure NN cord-303447-3a7jxl34 277 43 [ [ -LRB- cord-303447-3a7jxl34 277 44 81 81 CD cord-303447-3a7jxl34 277 45 ] ] -RRB- cord-303447-3a7jxl34 277 46 . . . cord-303447-3a7jxl34 278 1 These these DT cord-303447-3a7jxl34 278 2 emerging emerge VBG cord-303447-3a7jxl34 278 3 infectious infectious JJ cord-303447-3a7jxl34 278 4 diseases disease NNS cord-303447-3a7jxl34 278 5 and and CC cord-303447-3a7jxl34 278 6 the the DT cord-303447-3a7jxl34 278 7 need need NN cord-303447-3a7jxl34 278 8 to to TO cord-303447-3a7jxl34 278 9 prevent prevent VB cord-303447-3a7jxl34 278 10 them -PRON- PRP cord-303447-3a7jxl34 278 11 add add VB cord-303447-3a7jxl34 278 12 further further JJ cord-303447-3a7jxl34 278 13 complexity complexity NN cord-303447-3a7jxl34 278 14 to to IN cord-303447-3a7jxl34 278 15 immunization immunization NN cord-303447-3a7jxl34 278 16 schedules schedule NNS cord-303447-3a7jxl34 278 17 of of IN cord-303447-3a7jxl34 278 18 the the DT cord-303447-3a7jxl34 278 19 future future NN cord-303447-3a7jxl34 278 20 . . . cord-303447-3a7jxl34 279 1 Until until IN cord-303447-3a7jxl34 279 2 the the DT cord-303447-3a7jxl34 279 3 twentieth twentieth JJ cord-303447-3a7jxl34 279 4 century century NN cord-303447-3a7jxl34 279 5 , , , cord-303447-3a7jxl34 279 6 approximately approximately RB cord-303447-3a7jxl34 279 7 half half NN cord-303447-3a7jxl34 279 8 of of IN cord-303447-3a7jxl34 279 9 children child NNS cord-303447-3a7jxl34 279 10 in in IN cord-303447-3a7jxl34 279 11 the the DT cord-303447-3a7jxl34 279 12 United United NNP cord-303447-3a7jxl34 279 13 States States NNP cord-303447-3a7jxl34 279 14 died die VBD cord-303447-3a7jxl34 279 15 as as IN cord-303447-3a7jxl34 279 16 a a DT cord-303447-3a7jxl34 279 17 result result NN cord-303447-3a7jxl34 279 18 of of IN cord-303447-3a7jxl34 279 19 childhood childhood NN cord-303447-3a7jxl34 279 20 illness illness NN cord-303447-3a7jxl34 279 21 . . . cord-303447-3a7jxl34 280 1 Until until IN cord-303447-3a7jxl34 280 2 the the DT cord-303447-3a7jxl34 280 3 1920s 1920s CD cord-303447-3a7jxl34 280 4 , , , cord-303447-3a7jxl34 280 5 infectious infectious JJ cord-303447-3a7jxl34 280 6 diseases disease NNS cord-303447-3a7jxl34 280 7 were be VBD cord-303447-3a7jxl34 280 8 the the DT cord-303447-3a7jxl34 280 9 leading leading JJ cord-303447-3a7jxl34 280 10 cause cause NN cord-303447-3a7jxl34 280 11 of of IN cord-303447-3a7jxl34 280 12 death death NN cord-303447-3a7jxl34 280 13 in in IN cord-303447-3a7jxl34 280 14 the the DT cord-303447-3a7jxl34 280 15 United United NNP cord-303447-3a7jxl34 280 16 States States NNP cord-303447-3a7jxl34 280 17 . . . cord-303447-3a7jxl34 281 1 In in IN cord-303447-3a7jxl34 281 2 the the DT cord-303447-3a7jxl34 281 3 first first JJ cord-303447-3a7jxl34 281 4 edition edition NN cord-303447-3a7jxl34 281 5 of of IN cord-303447-3a7jxl34 281 6 the the DT cord-303447-3a7jxl34 281 7 Red Red NNP cord-303447-3a7jxl34 281 8 Book Book NNP cord-303447-3a7jxl34 281 9 published publish VBN cord-303447-3a7jxl34 281 10 by by IN cord-303447-3a7jxl34 281 11 the the DT cord-303447-3a7jxl34 281 12 AAP AAP NNP cord-303447-3a7jxl34 281 13 in in IN cord-303447-3a7jxl34 281 14 January January NNP cord-303447-3a7jxl34 281 15 1938 1938 CD cord-303447-3a7jxl34 281 16 , , , cord-303447-3a7jxl34 281 17 18 18 CD cord-303447-3a7jxl34 281 18 chapters chapter NNS cord-303447-3a7jxl34 281 19 dealt deal VBD cord-303447-3a7jxl34 281 20 with with IN cord-303447-3a7jxl34 281 21 infectious infectious JJ cord-303447-3a7jxl34 281 22 diseases disease NNS cord-303447-3a7jxl34 281 23 , , , cord-303447-3a7jxl34 281 24 ranging range VBG cord-303447-3a7jxl34 281 25 from from IN cord-303447-3a7jxl34 281 26 the the DT cord-303447-3a7jxl34 281 27 common common JJ cord-303447-3a7jxl34 281 28 cold cold NN cord-303447-3a7jxl34 281 29 to to IN cord-303447-3a7jxl34 281 30 smallpox smallpox NN cord-303447-3a7jxl34 281 31 . . . cord-303447-3a7jxl34 282 1 Except except IN cord-303447-3a7jxl34 282 2 for for IN cord-303447-3a7jxl34 282 3 pertussis pertussis NN cord-303447-3a7jxl34 282 4 , , , cord-303447-3a7jxl34 282 5 diphtheria diphtheria NN cord-303447-3a7jxl34 282 6 , , , cord-303447-3a7jxl34 282 7 and and CC cord-303447-3a7jxl34 282 8 Less less RBR cord-303447-3a7jxl34 282 9 favorable favorable JJ cord-303447-3a7jxl34 282 10 : : : cord-303447-3a7jxl34 282 11 vaccination vaccination NN cord-303447-3a7jxl34 282 12 strategy strategy NN cord-303447-3a7jxl34 282 13 would would MD cord-303447-3a7jxl34 282 14 incur incur VB cord-303447-3a7jxl34 282 15 significant significant JJ cord-303447-3a7jxl34 282 16 costs cost NNS cord-303447-3a7jxl34 282 17 ( ( -LRB- cord-303447-3a7jxl34 282 18 N$100,000-N$1 n$100,000-n$1 JJ cord-303447-3a7jxl34 282 19 million million CD cord-303447-3a7jxl34 282 20 per per IN cord-303447-3a7jxl34 282 21 QALY QALY NNP cord-303447-3a7jxl34 282 22 gained gain VBD cord-303447-3a7jxl34 282 23 ) ) -RRB- cord-303447-3a7jxl34 283 1 Borrelia Borrelia NNP cord-303447-3a7jxl34 283 2 burgdorferi burgdorferi NN cord-303447-3a7jxl34 283 3 vaccine vaccine NN cord-303447-3a7jxl34 283 4 given give VBN cord-303447-3a7jxl34 283 5 to to IN cord-303447-3a7jxl34 283 6 resident resident JJ cord-303447-3a7jxl34 283 7 infants infant NNS cord-303447-3a7jxl34 283 8 born bear VBN cord-303447-3a7jxl34 283 9 in in IN cord-303447-3a7jxl34 283 10 and and CC cord-303447-3a7jxl34 283 11 immigrants immigrant NNS cord-303447-3a7jxl34 283 12 of of IN cord-303447-3a7jxl34 283 13 any any DT cord-303447-3a7jxl34 283 14 age age NN cord-303447-3a7jxl34 283 15 to to TO cord-303447-3a7jxl34 283 16 geographically geographically RB cord-303447-3a7jxl34 283 17 defined define VBN cord-303447-3a7jxl34 283 18 highrisk highrisk NN cord-303447-3a7jxl34 283 19 areas area NNS cord-303447-3a7jxl34 284 1 Coccidioides Coccidioides NNP cord-303447-3a7jxl34 284 2 immitis immitis JJ cord-303447-3a7jxl34 284 3 vaccine vaccine NN cord-303447-3a7jxl34 284 4 given give VBN cord-303447-3a7jxl34 284 5 to to IN cord-303447-3a7jxl34 284 6 resident resident JJ cord-303447-3a7jxl34 284 7 infants infant NNS cord-303447-3a7jxl34 284 8 born bear VBN cord-303447-3a7jxl34 284 9 in in IN cord-303447-3a7jxl34 284 10 and and CC cord-303447-3a7jxl34 284 11 immigrants immigrant NNS cord-303447-3a7jxl34 284 12 of of IN cord-303447-3a7jxl34 284 13 any any DT cord-303447-3a7jxl34 284 14 age age NN cord-303447-3a7jxl34 284 15 to to TO cord-303447-3a7jxl34 284 16 geographically geographically RB cord-303447-3a7jxl34 284 17 defined define VBN cord-303447-3a7jxl34 284 18 highrisk highrisk NN cord-303447-3a7jxl34 284 19 areas area NNS cord-303447-3a7jxl34 284 20 Enterotoxigenic Enterotoxigenic NNP cord-303447-3a7jxl34 284 21 Escherichia Escherichia NNP cord-303447-3a7jxl34 284 22 coli coli VBZ cord-303447-3a7jxl34 284 23 vaccine vaccine NN cord-303447-3a7jxl34 284 24 administered administer VBN cord-303447-3a7jxl34 284 25 to to IN cord-303447-3a7jxl34 284 26 infants infant NNS cord-303447-3a7jxl34 284 27 and and CC cord-303447-3a7jxl34 284 28 travelers traveler NNS cord-303447-3a7jxl34 284 29 Epstein Epstein NNP cord-303447-3a7jxl34 284 30 - - HYPH cord-303447-3a7jxl34 284 31 Barr Barr NNP cord-303447-3a7jxl34 284 32 virus virus NN cord-303447-3a7jxl34 284 33 vaccine vaccine NN cord-303447-3a7jxl34 284 34 administered administer VBN cord-303447-3a7jxl34 284 35 to to IN cord-303447-3a7jxl34 284 36 12-year 12-year JJ cord-303447-3a7jxl34 284 37 - - HYPH cord-303447-3a7jxl34 284 38 olds old NNS cord-303447-3a7jxl34 284 39 Histoplasma Histoplasma NNP cord-303447-3a7jxl34 284 40 capsulatum capsulatum NN cord-303447-3a7jxl34 284 41 vaccine vaccine NN cord-303447-3a7jxl34 284 42 given give VBN cord-303447-3a7jxl34 284 43 to to IN cord-303447-3a7jxl34 284 44 resident resident JJ cord-303447-3a7jxl34 284 45 infants infant NNS cord-303447-3a7jxl34 284 46 born bear VBN cord-303447-3a7jxl34 284 47 in in IN cord-303447-3a7jxl34 284 48 and and CC cord-303447-3a7jxl34 284 49 immigrants immigrant NNS cord-303447-3a7jxl34 284 50 of of IN cord-303447-3a7jxl34 284 51 any any DT cord-303447-3a7jxl34 284 52 age age NN cord-303447-3a7jxl34 284 53 to to TO cord-303447-3a7jxl34 284 54 geographically geographically RB cord-303447-3a7jxl34 284 55 defined define VBN cord-303447-3a7jxl34 284 56 highrisk highrisk NN cord-303447-3a7jxl34 284 57 areas area NNS cord-303447-3a7jxl34 285 1 Neisseria Neisseria NNP cord-303447-3a7jxl34 285 2 meningitidis meningitidis NNP cord-303447-3a7jxl34 285 3 type type NN cord-303447-3a7jxl34 285 4 b b NNP cord-303447-3a7jxl34 285 5 vaccine vaccine NN cord-303447-3a7jxl34 285 6 given give VBN cord-303447-3a7jxl34 285 7 to to IN cord-303447-3a7jxl34 285 8 infants infant NNS cord-303447-3a7jxl34 285 9 Shigella Shigella NNP cord-303447-3a7jxl34 285 10 vaccine vaccine NN cord-303447-3a7jxl34 285 11 given give VBN cord-303447-3a7jxl34 285 12 to to IN cord-303447-3a7jxl34 285 13 infants infant NNS cord-303447-3a7jxl34 285 14 and and CC cord-303447-3a7jxl34 285 15 travelers traveler NNS cord-303447-3a7jxl34 285 16 or or CC cord-303447-3a7jxl34 285 17 travelers traveler NNS cord-303447-3a7jxl34 285 18 only only RB cord-303447-3a7jxl34 285 19 * * NFP cord-303447-3a7jxl34 285 20 Quality quality NN cord-303447-3a7jxl34 285 21 - - HYPH cord-303447-3a7jxl34 285 22 adjusted adjust VBN cord-303447-3a7jxl34 285 23 life life NN cord-303447-3a7jxl34 285 24 year year NN cord-303447-3a7jxl34 286 1 ( ( -LRB- cord-303447-3a7jxl34 286 2 QALY QALY NNP cord-303447-3a7jxl34 286 3 ) ) -RRB- cord-303447-3a7jxl34 286 4 takes take VBZ cord-303447-3a7jxl34 286 5 into into IN cord-303447-3a7jxl34 286 6 account account NN cord-303447-3a7jxl34 286 7 quantity quantity NN cord-303447-3a7jxl34 286 8 and and CC cord-303447-3a7jxl34 286 9 quality quality NN cord-303447-3a7jxl34 286 10 of of IN cord-303447-3a7jxl34 286 11 life life NN cord-303447-3a7jxl34 286 12 generated generate VBN cord-303447-3a7jxl34 286 13 by by IN cord-303447-3a7jxl34 286 14 health health NN cord-303447-3a7jxl34 286 15 care care NN cord-303447-3a7jxl34 286 16 interventions intervention NNS cord-303447-3a7jxl34 286 17 . . . cord-303447-3a7jxl34 287 1 QALY QALY NNP cord-303447-3a7jxl34 287 2 is be VBZ cord-303447-3a7jxl34 287 3 calculated calculate VBN cord-303447-3a7jxl34 287 4 by by IN cord-303447-3a7jxl34 287 5 placing place VBG cord-303447-3a7jxl34 287 6 a a DT cord-303447-3a7jxl34 287 7 weight weight NN cord-303447-3a7jxl34 287 8 on on IN cord-303447-3a7jxl34 287 9 time time NN cord-303447-3a7jxl34 287 10 in in IN cord-303447-3a7jxl34 287 11 different different JJ cord-303447-3a7jxl34 287 12 health health NN cord-303447-3a7jxl34 287 13 states state NNS cord-303447-3a7jxl34 287 14 . . . cord-303447-3a7jxl34 288 1 The the DT cord-303447-3a7jxl34 288 2 cost cost NN cord-303447-3a7jxl34 288 3 per per IN cord-303447-3a7jxl34 288 4 QALY QALY NNP cord-303447-3a7jxl34 288 5 is be VBZ cord-303447-3a7jxl34 288 6 the the DT cord-303447-3a7jxl34 288 7 cost cost NN cord-303447-3a7jxl34 288 8 required require VBN cord-303447-3a7jxl34 288 9 to to TO cord-303447-3a7jxl34 288 10 generate generate VB cord-303447-3a7jxl34 288 11 1 1 CD cord-303447-3a7jxl34 288 12 year year NN cord-303447-3a7jxl34 288 13 of of IN cord-303447-3a7jxl34 288 14 perfect perfect JJ cord-303447-3a7jxl34 288 15 health health NN cord-303447-3a7jxl34 288 16 . . . cord-303447-3a7jxl34 289 1 Data datum NNS cord-303447-3a7jxl34 289 2 from from IN cord-303447-3a7jxl34 289 3 www.iom.edu/vaccinepriorities www.iom.edu/vaccineprioritie NNS cord-303447-3a7jxl34 289 4 . . . cord-303447-3a7jxl34 289 5 tetanus tetanus NN cord-303447-3a7jxl34 289 6 , , , cord-303447-3a7jxl34 289 7 and and CC cord-303447-3a7jxl34 289 8 smallpox smallpox NN cord-303447-3a7jxl34 289 9 , , , cord-303447-3a7jxl34 289 10 active active JJ cord-303447-3a7jxl34 289 11 immunization immunization NN cord-303447-3a7jxl34 289 12 was be VBD cord-303447-3a7jxl34 289 13 not not RB cord-303447-3a7jxl34 289 14 available available JJ cord-303447-3a7jxl34 289 15 for for IN cord-303447-3a7jxl34 289 16 the the DT cord-303447-3a7jxl34 289 17 other other JJ cord-303447-3a7jxl34 289 18 14 14 CD cord-303447-3a7jxl34 289 19 conditions condition NNS cord-303447-3a7jxl34 289 20 in in IN cord-303447-3a7jxl34 289 21 this this DT cord-303447-3a7jxl34 289 22 edition edition NN cord-303447-3a7jxl34 289 23 . . . cord-303447-3a7jxl34 290 1 Currently currently RB cord-303447-3a7jxl34 290 2 , , , cord-303447-3a7jxl34 290 3 active active JJ cord-303447-3a7jxl34 290 4 immunization immunization NN cord-303447-3a7jxl34 290 5 exists exist VBZ cord-303447-3a7jxl34 290 6 for for IN cord-303447-3a7jxl34 290 7 12 12 CD cord-303447-3a7jxl34 290 8 of of IN cord-303447-3a7jxl34 290 9 the the DT cord-303447-3a7jxl34 290 10 18 18 CD cord-303447-3a7jxl34 290 11 diseases disease NNS cord-303447-3a7jxl34 290 12 contained contain VBN cord-303447-3a7jxl34 290 13 in in IN cord-303447-3a7jxl34 290 14 the the DT cord-303447-3a7jxl34 290 15 eight eight CD cord-303447-3a7jxl34 290 16 pages page NNS cord-303447-3a7jxl34 290 17 of of IN cord-303447-3a7jxl34 290 18 the the DT cord-303447-3a7jxl34 290 19 1938 1938 CD cord-303447-3a7jxl34 290 20 Red Red NNP cord-303447-3a7jxl34 290 21 Book Book NNP cord-303447-3a7jxl34 290 22 , , , cord-303447-3a7jxl34 290 23 and and CC cord-303447-3a7jxl34 290 24 one one CD cord-303447-3a7jxl34 290 25 disease disease NN cord-303447-3a7jxl34 290 26 , , , cord-303447-3a7jxl34 290 27 smallpox smallpox NN cord-303447-3a7jxl34 290 28 , , , cord-303447-3a7jxl34 290 29 has have VBZ cord-303447-3a7jxl34 290 30 been be VBN cord-303447-3a7jxl34 290 31 eradicated eradicate VBN cord-303447-3a7jxl34 290 32 . . . cord-303447-3a7jxl34 291 1 Since since IN cord-303447-3a7jxl34 291 2 then then RB cord-303447-3a7jxl34 291 3 , , , cord-303447-3a7jxl34 291 4 many many JJ cord-303447-3a7jxl34 291 5 other other JJ cord-303447-3a7jxl34 291 6 infectious infectious JJ cord-303447-3a7jxl34 291 7 disease disease NN cord-303447-3a7jxl34 291 8 have have VBP cord-303447-3a7jxl34 291 9 emerged emerge VBN cord-303447-3a7jxl34 291 10 or or CC cord-303447-3a7jxl34 291 11 reemerged reemerge VBN cord-303447-3a7jxl34 291 12 , , , cord-303447-3a7jxl34 291 13 including include VBG cord-303447-3a7jxl34 291 14 SARS SARS NNP cord-303447-3a7jxl34 291 15 , , , cord-303447-3a7jxl34 291 16 HIV HIV NNP cord-303447-3a7jxl34 291 17 , , , cord-303447-3a7jxl34 291 18 West West NNP cord-303447-3a7jxl34 291 19 Nile Nile NNP cord-303447-3a7jxl34 291 20 virus virus NN cord-303447-3a7jxl34 291 21 , , , cord-303447-3a7jxl34 291 22 metapneumovirus metapneumovirus NNP cord-303447-3a7jxl34 291 23 , , , cord-303447-3a7jxl34 291 24 avian avian JJ cord-303447-3a7jxl34 291 25 influenza influenza NN cord-303447-3a7jxl34 291 26 , , , cord-303447-3a7jxl34 291 27 and and CC cord-303447-3a7jxl34 291 28 methicillin methicillin NN cord-303447-3a7jxl34 291 29 - - HYPH cord-303447-3a7jxl34 291 30 resistant resistant JJ cord-303447-3a7jxl34 291 31 S. S. NNP cord-303447-3a7jxl34 291 32 aureus aureus NN cord-303447-3a7jxl34 291 33 . . . cord-303447-3a7jxl34 292 1 Many many JJ cord-303447-3a7jxl34 292 2 of of IN cord-303447-3a7jxl34 292 3 these these DT cord-303447-3a7jxl34 292 4 conditions condition NNS cord-303447-3a7jxl34 292 5 are be VBP cord-303447-3a7jxl34 292 6 expected expect VBN cord-303447-3a7jxl34 292 7 to to TO cord-303447-3a7jxl34 292 8 be be VB cord-303447-3a7jxl34 292 9 controlled control VBN cord-303447-3a7jxl34 292 10 in in IN cord-303447-3a7jxl34 292 11 the the DT cord-303447-3a7jxl34 292 12 future future NN cord-303447-3a7jxl34 292 13 by by IN cord-303447-3a7jxl34 292 14 immunizations immunization NNS cord-303447-3a7jxl34 292 15 . . . cord-303447-3a7jxl34 293 1 As as IN cord-303447-3a7jxl34 293 2 the the DT cord-303447-3a7jxl34 293 3 recommended recommend VBN cord-303447-3a7jxl34 293 4 childhood childhood NN cord-303447-3a7jxl34 293 5 and and CC cord-303447-3a7jxl34 293 6 adolescent adolescent JJ cord-303447-3a7jxl34 293 7 immunization immunization NN cord-303447-3a7jxl34 293 8 schedule schedule NN cord-303447-3a7jxl34 293 9 continues continue VBZ cord-303447-3a7jxl34 293 10 to to TO cord-303447-3a7jxl34 293 11 expand expand VB cord-303447-3a7jxl34 293 12 , , , cord-303447-3a7jxl34 293 13 the the DT cord-303447-3a7jxl34 293 14 US US NNP cord-303447-3a7jxl34 293 15 immunization immunization NN cord-303447-3a7jxl34 293 16 program program NN cord-303447-3a7jxl34 293 17 will will MD cord-303447-3a7jxl34 293 18 be be VB cord-303447-3a7jxl34 293 19 challenged challenge VBN cord-303447-3a7jxl34 293 20 to to TO cord-303447-3a7jxl34 293 21 integrate integrate VB cord-303447-3a7jxl34 293 22 novel novel JJ cord-303447-3a7jxl34 293 23 immunization immunization NN cord-303447-3a7jxl34 293 24 strategies strategy NNS cord-303447-3a7jxl34 293 25 into into IN cord-303447-3a7jxl34 293 26 the the DT cord-303447-3a7jxl34 293 27 current current JJ cord-303447-3a7jxl34 293 28 immunization immunization NN cord-303447-3a7jxl34 293 29 infrastructure infrastructure NN cord-303447-3a7jxl34 293 30 . . . cord-303447-3a7jxl34 294 1 The the DT cord-303447-3a7jxl34 294 2 impact impact NN cord-303447-3a7jxl34 294 3 of of IN cord-303447-3a7jxl34 294 4 future future JJ cord-303447-3a7jxl34 294 5 vaccines vaccine NNS cord-303447-3a7jxl34 294 6 in in IN cord-303447-3a7jxl34 294 7 the the DT cord-303447-3a7jxl34 294 8 United United NNP cord-303447-3a7jxl34 294 9 States States NNP cord-303447-3a7jxl34 294 10 will will MD cord-303447-3a7jxl34 294 11 be be VB cord-303447-3a7jxl34 294 12 more more RBR cord-303447-3a7jxl34 294 13 difficult difficult JJ cord-303447-3a7jxl34 294 14 to to TO cord-303447-3a7jxl34 294 15 calculate calculate VB cord-303447-3a7jxl34 294 16 because because IN cord-303447-3a7jxl34 294 17 they -PRON- PRP cord-303447-3a7jxl34 294 18 will will MD cord-303447-3a7jxl34 294 19 prevent prevent VB cord-303447-3a7jxl34 294 20 fewer few JJR cord-303447-3a7jxl34 294 21 deaths death NNS cord-303447-3a7jxl34 294 22 than than IN cord-303447-3a7jxl34 294 23 vaccines vaccine NNS cord-303447-3a7jxl34 294 24 in in IN cord-303447-3a7jxl34 294 25 the the DT cord-303447-3a7jxl34 294 26 past past NN cord-303447-3a7jxl34 294 27 . . . cord-303447-3a7jxl34 295 1 The the DT cord-303447-3a7jxl34 295 2 cost cost NN cord-303447-3a7jxl34 295 3 of of IN cord-303447-3a7jxl34 295 4 these these DT cord-303447-3a7jxl34 295 5 vaccines vaccine NNS cord-303447-3a7jxl34 295 6 will will MD cord-303447-3a7jxl34 295 7 continue continue VB cord-303447-3a7jxl34 295 8 to to TO cord-303447-3a7jxl34 295 9 increase increase VB cord-303447-3a7jxl34 295 10 , , , cord-303447-3a7jxl34 295 11 and and CC cord-303447-3a7jxl34 295 12 funding funding NN cord-303447-3a7jxl34 295 13 support support NN cord-303447-3a7jxl34 295 14 will will MD cord-303447-3a7jxl34 295 15 be be VB cord-303447-3a7jxl34 295 16 challenged challenge VBN cord-303447-3a7jxl34 295 17 . . . cord-303447-3a7jxl34 296 1 The the DT cord-303447-3a7jxl34 296 2 risk risk NN cord-303447-3a7jxl34 296 3 of of IN cord-303447-3a7jxl34 296 4 adverse adverse JJ cord-303447-3a7jxl34 296 5 vaccine vaccine NN cord-303447-3a7jxl34 296 6 events event NNS cord-303447-3a7jxl34 296 7 will will MD cord-303447-3a7jxl34 296 8 have have VB cord-303447-3a7jxl34 296 9 to to TO cord-303447-3a7jxl34 296 10 be be VB cord-303447-3a7jxl34 296 11 weighed weigh VBN cord-303447-3a7jxl34 296 12 against against IN cord-303447-3a7jxl34 296 13 the the DT cord-303447-3a7jxl34 296 14 risk risk NN cord-303447-3a7jxl34 296 15 of of IN cord-303447-3a7jxl34 296 16 the the DT cord-303447-3a7jxl34 296 17 disease disease NN cord-303447-3a7jxl34 296 18 if if IN cord-303447-3a7jxl34 296 19 not not RB cord-303447-3a7jxl34 296 20 vaccinated vaccinate VBN cord-303447-3a7jxl34 296 21 . . . cord-303447-3a7jxl34 297 1 Pediatric pediatric JJ cord-303447-3a7jxl34 297 2 health health NN cord-303447-3a7jxl34 297 3 care care NN cord-303447-3a7jxl34 297 4 providers provider NNS cord-303447-3a7jxl34 297 5 face face VBP cord-303447-3a7jxl34 297 6 a a DT cord-303447-3a7jxl34 297 7 growing grow VBG cord-303447-3a7jxl34 297 8 complexity complexity NN cord-303447-3a7jxl34 297 9 of of IN cord-303447-3a7jxl34 297 10 problems problem NNS cord-303447-3a7jxl34 297 11 in in IN cord-303447-3a7jxl34 297 12 children child NNS cord-303447-3a7jxl34 297 13 , , , cord-303447-3a7jxl34 297 14 including include VBG cord-303447-3a7jxl34 297 15 injury injury NN cord-303447-3a7jxl34 297 16 , , , cord-303447-3a7jxl34 297 17 obesity obesity NN cord-303447-3a7jxl34 297 18 , , , cord-303447-3a7jxl34 297 19 asthma asthma NN cord-303447-3a7jxl34 297 20 , , , cord-303447-3a7jxl34 297 21 and and CC cord-303447-3a7jxl34 297 22 mental mental JJ cord-303447-3a7jxl34 297 23 health health NN cord-303447-3a7jxl34 297 24 and and CC cord-303447-3a7jxl34 297 25 behavioral behavioral JJ cord-303447-3a7jxl34 297 26 disorders disorder NNS cord-303447-3a7jxl34 297 27 . . . cord-303447-3a7jxl34 298 1 As as IN cord-303447-3a7jxl34 298 2 the the DT cord-303447-3a7jxl34 298 3 cost cost NN cord-303447-3a7jxl34 298 4 and and CC cord-303447-3a7jxl34 298 5 complexity complexity NN cord-303447-3a7jxl34 298 6 of of IN cord-303447-3a7jxl34 298 7 the the DT cord-303447-3a7jxl34 298 8 childhood childhood NN cord-303447-3a7jxl34 298 9 and and CC cord-303447-3a7jxl34 298 10 adolescent adolescent JJ cord-303447-3a7jxl34 298 11 immunization immunization NN cord-303447-3a7jxl34 298 12 schedule schedule NN cord-303447-3a7jxl34 298 13 increase increase NN cord-303447-3a7jxl34 298 14 , , , cord-303447-3a7jxl34 298 15 considering consider VBG cord-303447-3a7jxl34 298 16 the the DT cord-303447-3a7jxl34 298 17 role role NN cord-303447-3a7jxl34 298 18 of of IN cord-303447-3a7jxl34 298 19 immunizations immunization NNS cord-303447-3a7jxl34 298 20 within within IN cord-303447-3a7jxl34 298 21 the the DT cord-303447-3a7jxl34 298 22 context context NN cord-303447-3a7jxl34 298 23 of of IN cord-303447-3a7jxl34 298 24 other other JJ cord-303447-3a7jxl34 298 25 preventive preventive JJ cord-303447-3a7jxl34 298 26 health health NN cord-303447-3a7jxl34 298 27 interventions intervention NNS cord-303447-3a7jxl34 298 28 and and CC cord-303447-3a7jxl34 298 29 overall overall JJ cord-303447-3a7jxl34 298 30 societal societal JJ cord-303447-3a7jxl34 298 31 values value NNS cord-303447-3a7jxl34 298 32 becomes become VBZ cord-303447-3a7jxl34 298 33 increasingly increasingly RB cord-303447-3a7jxl34 298 34 important important JJ cord-303447-3a7jxl34 298 35 . . . cord-303447-3a7jxl34 299 1 Immunizations immunization NNS cord-303447-3a7jxl34 299 2 are be VBP cord-303447-3a7jxl34 299 3 one one CD cord-303447-3a7jxl34 299 4 of of IN cord-303447-3a7jxl34 299 5 the the DT cord-303447-3a7jxl34 299 6 most most RBS cord-303447-3a7jxl34 299 7 effective effective JJ cord-303447-3a7jxl34 299 8 clinical clinical JJ cord-303447-3a7jxl34 299 9 preventive preventive JJ cord-303447-3a7jxl34 299 10 services service NNS cord-303447-3a7jxl34 299 11 in in IN cord-303447-3a7jxl34 299 12 pediatric pediatric JJ cord-303447-3a7jxl34 299 13 practice practice NN cord-303447-3a7jxl34 299 14 [ [ -LRB- cord-303447-3a7jxl34 299 15 15 15 CD cord-303447-3a7jxl34 299 16 ] ] -RRB- cord-303447-3a7jxl34 299 17 . . . cord-303447-3a7jxl34 300 1 Despite despite IN cord-303447-3a7jxl34 300 2 the the DT cord-303447-3a7jxl34 300 3 challenges challenge NNS cord-303447-3a7jxl34 300 4 facing face VBG cord-303447-3a7jxl34 300 5 the the DT cord-303447-3a7jxl34 300 6 US US NNP cord-303447-3a7jxl34 300 7 immunization immunization NN cord-303447-3a7jxl34 300 8 program program NN cord-303447-3a7jxl34 300 9 , , , cord-303447-3a7jxl34 300 10 immunizations immunization NNS cord-303447-3a7jxl34 300 11 will will MD cord-303447-3a7jxl34 300 12 likely likely RB cord-303447-3a7jxl34 300 13 remain remain VB cord-303447-3a7jxl34 300 14 on on IN cord-303447-3a7jxl34 300 15 the the DT cord-303447-3a7jxl34 300 16 list list NN cord-303447-3a7jxl34 300 17 of of IN cord-303447-3a7jxl34 300 18 great great JJ cord-303447-3a7jxl34 300 19 public public JJ cord-303447-3a7jxl34 300 20 health health NN cord-303447-3a7jxl34 300 21 accomplishments accomplishment NNS cord-303447-3a7jxl34 300 22 of of IN cord-303447-3a7jxl34 300 23 the the DT cord-303447-3a7jxl34 300 24 twenty twenty CD cord-303447-3a7jxl34 300 25 - - HYPH cord-303447-3a7jxl34 300 26 first first JJ cord-303447-3a7jxl34 300 27 century century NN cord-303447-3a7jxl34 300 28 , , , cord-303447-3a7jxl34 300 29 and and CC cord-303447-3a7jxl34 300 30 the the DT cord-303447-3a7jxl34 300 31 legacy legacy NN cord-303447-3a7jxl34 300 32 of of IN cord-303447-3a7jxl34 300 33 Jenner Jenner NNP cord-303447-3a7jxl34 300 34 will will MD cord-303447-3a7jxl34 300 35 continue continue VB cord-303447-3a7jxl34 300 36 . . . cord-303447-3a7jxl34 301 1 Smallpox smallpox NN cord-303447-3a7jxl34 301 2 and and CC cord-303447-3a7jxl34 301 3 its -PRON- PRP$ cord-303447-3a7jxl34 301 4 eradication eradication NN cord-303447-3a7jxl34 301 5 . . . cord-303447-3a7jxl34 302 1 Geneva7 Geneva7 NNP cord-303447-3a7jxl34 303 1 WHO who WP cord-303447-3a7jxl34 303 2 Ten ten CD cord-303447-3a7jxl34 303 3 great great JJ cord-303447-3a7jxl34 303 4 public public JJ cord-303447-3a7jxl34 303 5 health health NN cord-303447-3a7jxl34 303 6 achievements achievement NNS cord-303447-3a7jxl34 303 7 , , , cord-303447-3a7jxl34 303 8 United United NNP cord-303447-3a7jxl34 303 9 States States NNP cord-303447-3a7jxl34 303 10 Impact Impact NNP cord-303447-3a7jxl34 303 11 of of IN cord-303447-3a7jxl34 303 12 vaccines vaccine NNS cord-303447-3a7jxl34 303 13 universally universally RB cord-303447-3a7jxl34 303 14 recommended recommend VBN cord-303447-3a7jxl34 303 15 for for IN cord-303447-3a7jxl34 303 16 children child NNS cord-303447-3a7jxl34 303 17 - - : cord-303447-3a7jxl34 303 18 United United NNP cord-303447-3a7jxl34 303 19 States States NNP cord-303447-3a7jxl34 303 20 Measles Measles NNP cord-303447-3a7jxl34 303 21 elimination elimination NN cord-303447-3a7jxl34 303 22 in in IN cord-303447-3a7jxl34 303 23 the the DT cord-303447-3a7jxl34 303 24 United United NNP cord-303447-3a7jxl34 303 25 States States NNP cord-303447-3a7jxl34 303 26 Epidemiology Epidemiology NNP cord-303447-3a7jxl34 303 27 of of IN cord-303447-3a7jxl34 303 28 poliomyelitis poliomyelitis NN cord-303447-3a7jxl34 303 29 in in IN cord-303447-3a7jxl34 303 30 the the DT cord-303447-3a7jxl34 303 31 United United NNP cord-303447-3a7jxl34 303 32 States States NNP cord-303447-3a7jxl34 304 1 one one CD cord-303447-3a7jxl34 304 2 decade decade NN cord-303447-3a7jxl34 304 3 after after IN cord-303447-3a7jxl34 304 4 the the DT cord-303447-3a7jxl34 304 5 last last JJ cord-303447-3a7jxl34 304 6 reported report VBN cord-303447-3a7jxl34 304 7 case case NN cord-303447-3a7jxl34 304 8 of of IN cord-303447-3a7jxl34 304 9 indigenous indigenous JJ cord-303447-3a7jxl34 304 10 wild wild JJ cord-303447-3a7jxl34 304 11 virus virus NN cord-303447-3a7jxl34 304 12 - - HYPH cord-303447-3a7jxl34 304 13 associated associate VBN cord-303447-3a7jxl34 304 14 disease disease NN cord-303447-3a7jxl34 304 15 Healthy healthy JJ cord-303447-3a7jxl34 304 16 people people NNS cord-303447-3a7jxl34 304 17 2010 2010 CD cord-303447-3a7jxl34 304 18 : : : cord-303447-3a7jxl34 304 19 national national JJ cord-303447-3a7jxl34 304 20 health health NN cord-303447-3a7jxl34 304 21 promotion promotion NN cord-303447-3a7jxl34 304 22 and and CC cord-303447-3a7jxl34 304 23 disease disease NN cord-303447-3a7jxl34 304 24 prevention prevention NN cord-303447-3a7jxl34 304 25 objectives objective NNS cord-303447-3a7jxl34 304 26 Haemophilus haemophilus JJ cord-303447-3a7jxl34 304 27 influenzae influenzae NN cord-303447-3a7jxl34 304 28 invasive invasive JJ cord-303447-3a7jxl34 304 29 disease disease NN cord-303447-3a7jxl34 304 30 in in IN cord-303447-3a7jxl34 304 31 the the DT cord-303447-3a7jxl34 304 32 United United NNP cord-303447-3a7jxl34 304 33 States States NNP cord-303447-3a7jxl34 304 34 , , , cord-303447-3a7jxl34 304 35 1994 1994 CD cord-303447-3a7jxl34 304 36 - - SYM cord-303447-3a7jxl34 304 37 1995 1995 CD cord-303447-3a7jxl34 304 38 : : : cord-303447-3a7jxl34 304 39 near near IN cord-303447-3a7jxl34 304 40 disappearance disappearance NN cord-303447-3a7jxl34 304 41 of of IN cord-303447-3a7jxl34 304 42 a a DT cord-303447-3a7jxl34 304 43 vaccine vaccine NN cord-303447-3a7jxl34 304 44 - - HYPH cord-303447-3a7jxl34 304 45 preventable preventable JJ cord-303447-3a7jxl34 304 46 childhood childhood NN cord-303447-3a7jxl34 304 47 disease disease NN cord-303447-3a7jxl34 304 48 Recommended recommend VBD cord-303447-3a7jxl34 304 49 childhood childhood NN cord-303447-3a7jxl34 304 50 and and CC cord-303447-3a7jxl34 304 51 adolescent adolescent JJ cord-303447-3a7jxl34 304 52 immunization immunization NN cord-303447-3a7jxl34 304 53 schedule schedule NN cord-303447-3a7jxl34 304 54 - - : cord-303447-3a7jxl34 304 55 United United NNP cord-303447-3a7jxl34 304 56 States States NNP cord-303447-3a7jxl34 304 57 Advisory Advisory NNP cord-303447-3a7jxl34 304 58 Committee Committee NNP cord-303447-3a7jxl34 304 59 on on IN cord-303447-3a7jxl34 304 60 Immunization Immunization NNP cord-303447-3a7jxl34 304 61 Practices Practices NNPS cord-303447-3a7jxl34 304 62 , , , cord-303447-3a7jxl34 304 63 American American NNP cord-303447-3a7jxl34 304 64 Academy Academy NNP cord-303447-3a7jxl34 304 65 of of IN cord-303447-3a7jxl34 304 66 Pediatrics Pediatrics NNP cord-303447-3a7jxl34 304 67 , , , cord-303447-3a7jxl34 304 68 American American NNP cord-303447-3a7jxl34 304 69 Academy Academy NNP cord-303447-3a7jxl34 304 70 of of IN cord-303447-3a7jxl34 304 71 Family Family NNP cord-303447-3a7jxl34 304 72 Physicians Physicians NNPS cord-303447-3a7jxl34 304 73 , , , cord-303447-3a7jxl34 304 74 National National NNP cord-303447-3a7jxl34 304 75 Immunization Immunization NNP cord-303447-3a7jxl34 304 76 Program Program NNP cord-303447-3a7jxl34 304 77 Development Development NNP cord-303447-3a7jxl34 304 78 of of IN cord-303447-3a7jxl34 304 79 pediatric pediatric JJ cord-303447-3a7jxl34 304 80 vaccine vaccine NN cord-303447-3a7jxl34 304 81 recommendations recommendation NNS cord-303447-3a7jxl34 304 82 and and CC cord-303447-3a7jxl34 304 83 policies policy NNS cord-303447-3a7jxl34 304 84 Vaccination vaccination NN cord-303447-3a7jxl34 304 85 policies policy NNS cord-303447-3a7jxl34 304 86 and and CC cord-303447-3a7jxl34 304 87 programs program NNS cord-303447-3a7jxl34 304 88 : : : cord-303447-3a7jxl34 304 89 the the DT cord-303447-3a7jxl34 304 90 federal federal JJ cord-303447-3a7jxl34 304 91 government government NN cord-303447-3a7jxl34 304 92 's 's POS cord-303447-3a7jxl34 304 93 role role NN cord-303447-3a7jxl34 304 94 in in IN cord-303447-3a7jxl34 304 95 making make VBG cord-303447-3a7jxl34 304 96 the the DT cord-303447-3a7jxl34 304 97 system system NN cord-303447-3a7jxl34 304 98 work work NN cord-303447-3a7jxl34 304 99 Financing financing NN cord-303447-3a7jxl34 304 100 immunizations immunization NNS cord-303447-3a7jxl34 304 101 in in IN cord-303447-3a7jxl34 304 102 the the DT cord-303447-3a7jxl34 304 103 United United NNP cord-303447-3a7jxl34 304 104 States States NNP cord-303447-3a7jxl34 304 105 Cost cost NN cord-303447-3a7jxl34 304 106 - - HYPH cord-303447-3a7jxl34 304 107 effectiveness effectiveness NN cord-303447-3a7jxl34 304 108 of of IN cord-303447-3a7jxl34 304 109 a a DT cord-303447-3a7jxl34 304 110 routine routine JJ cord-303447-3a7jxl34 304 111 varicella varicella NN cord-303447-3a7jxl34 304 112 vaccination vaccination NN cord-303447-3a7jxl34 304 113 program program NN cord-303447-3a7jxl34 304 114 for for IN cord-303447-3a7jxl34 304 115 US US NNP cord-303447-3a7jxl34 304 116 children child NNS cord-303447-3a7jxl34 305 1 Projected project VBN cord-303447-3a7jxl34 305 2 cost cost NN cord-303447-3a7jxl34 305 3 - - HYPH cord-303447-3a7jxl34 305 4 effectiveness effectiveness NN cord-303447-3a7jxl34 305 5 of of IN cord-303447-3a7jxl34 305 6 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 305 7 conjugate conjugate NN cord-303447-3a7jxl34 305 8 vaccination vaccination NN cord-303447-3a7jxl34 305 9 of of IN cord-303447-3a7jxl34 305 10 healthy healthy JJ cord-303447-3a7jxl34 305 11 infants infant NNS cord-303447-3a7jxl34 305 12 and and CC cord-303447-3a7jxl34 305 13 young young JJ cord-303447-3a7jxl34 305 14 children child NNS cord-303447-3a7jxl34 305 15 Priorities Priorities NNPS cord-303447-3a7jxl34 305 16 among among IN cord-303447-3a7jxl34 305 17 recommended recommend VBN cord-303447-3a7jxl34 305 18 clinical clinical JJ cord-303447-3a7jxl34 305 19 preventive preventive JJ cord-303447-3a7jxl34 305 20 services service NNS cord-303447-3a7jxl34 305 21 Cost cost NN cord-303447-3a7jxl34 305 22 - - HYPH cord-303447-3a7jxl34 305 23 effectiveness effectiveness NN cord-303447-3a7jxl34 305 24 of of IN cord-303447-3a7jxl34 305 25 hepatitis hepatitis NN cord-303447-3a7jxl34 305 26 B B NNP cord-303447-3a7jxl34 305 27 virus virus NN cord-303447-3a7jxl34 305 28 immunization immunization NN cord-303447-3a7jxl34 305 29 Strengthening strengthen VBG cord-303447-3a7jxl34 305 30 the the DT cord-303447-3a7jxl34 305 31 supply supply NN cord-303447-3a7jxl34 305 32 of of IN cord-303447-3a7jxl34 305 33 routinely routinely RB cord-303447-3a7jxl34 305 34 recommended recommend VBN cord-303447-3a7jxl34 305 35 vaccines vaccine NNS cord-303447-3a7jxl34 305 36 in in IN cord-303447-3a7jxl34 305 37 the the DT cord-303447-3a7jxl34 305 38 United United NNP cord-303447-3a7jxl34 305 39 States States NNP cord-303447-3a7jxl34 305 40 : : : cord-303447-3a7jxl34 306 1 recommendations recommendation NNS cord-303447-3a7jxl34 306 2 from from IN cord-303447-3a7jxl34 306 3 the the DT cord-303447-3a7jxl34 306 4 National National NNP cord-303447-3a7jxl34 306 5 Vaccine Vaccine NNP cord-303447-3a7jxl34 306 6 Advisory Advisory NNP cord-303447-3a7jxl34 306 7 Committee Committee NNP cord-303447-3a7jxl34 306 8 Centers Centers NNPS cord-303447-3a7jxl34 306 9 for for IN cord-303447-3a7jxl34 306 10 Disease Disease NNP cord-303447-3a7jxl34 306 11 Control Control NNP cord-303447-3a7jxl34 306 12 and and CC cord-303447-3a7jxl34 306 13 Prevention Prevention NNP cord-303447-3a7jxl34 306 14 . . . cord-303447-3a7jxl34 307 1 Shortage shortage NN cord-303447-3a7jxl34 307 2 of of IN cord-303447-3a7jxl34 307 3 tetanus tetanus NN cord-303447-3a7jxl34 307 4 and and CC cord-303447-3a7jxl34 307 5 diphtheria diphtheria NN cord-303447-3a7jxl34 307 6 toxoids toxoid NNS cord-303447-3a7jxl34 307 7 Update Update NNP cord-303447-3a7jxl34 307 8 on on IN cord-303447-3a7jxl34 307 9 the the DT cord-303447-3a7jxl34 307 10 supply supply NN cord-303447-3a7jxl34 307 11 of of IN cord-303447-3a7jxl34 307 12 tetanus tetanus NN cord-303447-3a7jxl34 307 13 and and CC cord-303447-3a7jxl34 307 14 diphtheria diphtheria NN cord-303447-3a7jxl34 307 15 toxoids toxoid NNS cord-303447-3a7jxl34 307 16 and and CC cord-303447-3a7jxl34 307 17 of of IN cord-303447-3a7jxl34 307 18 diphtheria diphtheria NN cord-303447-3a7jxl34 307 19 and and CC cord-303447-3a7jxl34 307 20 tetanus tetanus NN cord-303447-3a7jxl34 307 21 toxoids toxoid NNS cord-303447-3a7jxl34 307 22 and and CC cord-303447-3a7jxl34 307 23 acellular acellular JJ cord-303447-3a7jxl34 307 24 pertussis pertussis NN cord-303447-3a7jxl34 307 25 vaccine vaccine NN cord-303447-3a7jxl34 307 26 Notice notice NN cord-303447-3a7jxl34 307 27 to to IN cord-303447-3a7jxl34 307 28 readers reader NNS cord-303447-3a7jxl34 307 29 : : : cord-303447-3a7jxl34 307 30 decreased decrease VBN cord-303447-3a7jxl34 307 31 availability availability NN cord-303447-3a7jxl34 307 32 of of IN cord-303447-3a7jxl34 307 33 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 307 34 conjugate conjugate JJ cord-303447-3a7jxl34 307 35 vaccine vaccine NN cord-303447-3a7jxl34 307 36 Shortage shortage NN cord-303447-3a7jxl34 307 37 of of IN cord-303447-3a7jxl34 307 38 varicella varicella NN cord-303447-3a7jxl34 307 39 and and CC cord-303447-3a7jxl34 307 40 measles measle NNS cord-303447-3a7jxl34 307 41 , , , cord-303447-3a7jxl34 307 42 mumps mumps NN cord-303447-3a7jxl34 307 43 and and CC cord-303447-3a7jxl34 307 44 rubella rubella NN cord-303447-3a7jxl34 307 45 vaccines vaccine NNS cord-303447-3a7jxl34 307 46 and and CC cord-303447-3a7jxl34 307 47 interim interim JJ cord-303447-3a7jxl34 307 48 recommendations recommendation NNS cord-303447-3a7jxl34 307 49 from from IN cord-303447-3a7jxl34 307 50 the the DT cord-303447-3a7jxl34 307 51 Advisory Advisory NNP cord-303447-3a7jxl34 307 52 Committee Committee NNP cord-303447-3a7jxl34 307 53 on on IN cord-303447-3a7jxl34 307 54 Immunization Immunization NNP cord-303447-3a7jxl34 307 55 Practices Practices NNPS cord-303447-3a7jxl34 307 56 Experiences experience NNS cord-303447-3a7jxl34 307 57 with with IN cord-303447-3a7jxl34 307 58 obtaining obtain VBG cord-303447-3a7jxl34 307 59 influenza influenza NN cord-303447-3a7jxl34 307 60 vaccination vaccination NN cord-303447-3a7jxl34 307 61 among among IN cord-303447-3a7jxl34 307 62 persons person NNS cord-303447-3a7jxl34 307 63 in in IN cord-303447-3a7jxl34 307 64 priority priority NN cord-303447-3a7jxl34 307 65 groups group NNS cord-303447-3a7jxl34 307 66 during during IN cord-303447-3a7jxl34 307 67 a a DT cord-303447-3a7jxl34 307 68 vaccine vaccine NN cord-303447-3a7jxl34 307 69 shortage shortage NN cord-303447-3a7jxl34 307 70 - - : cord-303447-3a7jxl34 307 71 United United NNP cord-303447-3a7jxl34 307 72 States States NNP cord-303447-3a7jxl34 307 73 Notice Notice NNP cord-303447-3a7jxl34 307 74 to to IN cord-303447-3a7jxl34 307 75 readers reader NNS cord-303447-3a7jxl34 307 76 : : : cord-303447-3a7jxl34 307 77 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 307 78 conjugate conjugate JJ cord-303447-3a7jxl34 307 79 vaccine vaccine NN cord-303447-3a7jxl34 307 80 shortage shortage NN cord-303447-3a7jxl34 307 81 resolved resolve VBD cord-303447-3a7jxl34 307 82 Impact Impact NNP cord-303447-3a7jxl34 307 83 of of IN cord-303447-3a7jxl34 307 84 vaccine vaccine NN cord-303447-3a7jxl34 307 85 shortages shortage NNS cord-303447-3a7jxl34 307 86 on on IN cord-303447-3a7jxl34 307 87 immunization immunization NN cord-303447-3a7jxl34 307 88 programs program NNS cord-303447-3a7jxl34 307 89 and and CC cord-303447-3a7jxl34 307 90 providers provider NNS cord-303447-3a7jxl34 307 91 Variation Variation NNP cord-303447-3a7jxl34 307 92 in in IN cord-303447-3a7jxl34 307 93 public public JJ cord-303447-3a7jxl34 307 94 and and CC cord-303447-3a7jxl34 307 95 private private JJ cord-303447-3a7jxl34 307 96 supply supply NN cord-303447-3a7jxl34 307 97 of of IN cord-303447-3a7jxl34 307 98 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 307 99 conjugate conjugate JJ cord-303447-3a7jxl34 307 100 vaccine vaccine NN cord-303447-3a7jxl34 307 101 during during IN cord-303447-3a7jxl34 307 102 a a DT cord-303447-3a7jxl34 307 103 shortage shortage NN cord-303447-3a7jxl34 307 104 Limited limited JJ cord-303447-3a7jxl34 307 105 supply supply NN cord-303447-3a7jxl34 307 106 of of IN cord-303447-3a7jxl34 307 107 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 307 108 conjugate conjugate NN cord-303447-3a7jxl34 307 109 vaccine vaccine NN cord-303447-3a7jxl34 307 110 : : : cord-303447-3a7jxl34 307 111 suspension suspension NN cord-303447-3a7jxl34 307 112 of of IN cord-303447-3a7jxl34 307 113 recommendation recommendation NN cord-303447-3a7jxl34 307 114 for for IN cord-303447-3a7jxl34 307 115 fourth fourth JJ cord-303447-3a7jxl34 307 116 dose dose NN cord-303447-3a7jxl34 307 117 Report Report NNP cord-303447-3a7jxl34 307 118 to to IN cord-303447-3a7jxl34 307 119 congressional congressional JJ cord-303447-3a7jxl34 307 120 requesters requester NNS cord-303447-3a7jxl34 307 121 : : : cord-303447-3a7jxl34 307 122 childhood childhood NN cord-303447-3a7jxl34 307 123 vaccines vaccine NNS cord-303447-3a7jxl34 307 124 : : : cord-303447-3a7jxl34 307 125 ensuring ensure VBG cord-303447-3a7jxl34 307 126 an an DT cord-303447-3a7jxl34 307 127 adequate adequate JJ cord-303447-3a7jxl34 307 128 supply supply NN cord-303447-3a7jxl34 307 129 poses pose VBZ cord-303447-3a7jxl34 307 130 continuing continue VBG cord-303447-3a7jxl34 307 131 challenges challenge NNS cord-303447-3a7jxl34 307 132 Safety safety NN cord-303447-3a7jxl34 307 133 of of IN cord-303447-3a7jxl34 307 134 immunizations immunization NNS cord-303447-3a7jxl34 307 135 : : : cord-303447-3a7jxl34 307 136 vaccine vaccine NN cord-303447-3a7jxl34 307 137 Centers Centers NNPS cord-303447-3a7jxl34 307 138 for for IN cord-303447-3a7jxl34 307 139 Disease Disease NNP cord-303447-3a7jxl34 307 140 Control Control NNP cord-303447-3a7jxl34 307 141 and and CC cord-303447-3a7jxl34 307 142 Prevention Prevention NNP cord-303447-3a7jxl34 307 143 . . . cord-303447-3a7jxl34 308 1 Poliomyelitis poliomyelitis NN cord-303447-3a7jxl34 308 2 prevention prevention NN cord-303447-3a7jxl34 308 3 in in IN cord-303447-3a7jxl34 308 4 the the DT cord-303447-3a7jxl34 308 5 United United NNP cord-303447-3a7jxl34 308 6 States States NNP cord-303447-3a7jxl34 308 7 : : : cord-303447-3a7jxl34 308 8 updated update VBN cord-303447-3a7jxl34 308 9 recommendations recommendation NNS cord-303447-3a7jxl34 308 10 of of IN cord-303447-3a7jxl34 308 11 the the DT cord-303447-3a7jxl34 308 12 Advisory Advisory NNP cord-303447-3a7jxl34 308 13 Committee Committee NNP cord-303447-3a7jxl34 308 14 on on IN cord-303447-3a7jxl34 308 15 Immunization Immunization NNP cord-303447-3a7jxl34 308 16 Practices Practices NNPS cord-303447-3a7jxl34 308 17 ( ( -LRB- cord-303447-3a7jxl34 308 18 ACIP ACIP NNP cord-303447-3a7jxl34 308 19 ) ) -RRB- cord-303447-3a7jxl34 308 20 Immunization Immunization NNP cord-303447-3a7jxl34 308 21 safety safety NN cord-303447-3a7jxl34 308 22 review review NN cord-303447-3a7jxl34 308 23 : : : cord-303447-3a7jxl34 308 24 committee committee NN cord-303447-3a7jxl34 308 25 reports report NNS cord-303447-3a7jxl34 308 26 . . . cord-303447-3a7jxl34 309 1 Washington Washington NNP cord-303447-3a7jxl34 309 2 , , , cord-303447-3a7jxl34 309 3 DC7 DC7 NNP cord-303447-3a7jxl34 309 4 National National NNP cord-303447-3a7jxl34 309 5 Academy Academy NNP cord-303447-3a7jxl34 309 6 of of IN cord-303447-3a7jxl34 309 7 Sciences Sciences NNPS cord-303447-3a7jxl34 309 8 Understanding Understanding NNP cord-303447-3a7jxl34 309 9 vaccine vaccine NN cord-303447-3a7jxl34 309 10 safety safety NN cord-303447-3a7jxl34 309 11 information information NN cord-303447-3a7jxl34 309 12 from from IN cord-303447-3a7jxl34 309 13 the the DT cord-303447-3a7jxl34 309 14 Vaccine Vaccine NNP cord-303447-3a7jxl34 309 15 Adverse Adverse NNP cord-303447-3a7jxl34 309 16 Event Event NNP cord-303447-3a7jxl34 309 17 Reporting Reporting NNP cord-303447-3a7jxl34 309 18 System System NNP cord-303447-3a7jxl34 309 19 Withdrawal Withdrawal NNP cord-303447-3a7jxl34 309 20 of of IN cord-303447-3a7jxl34 309 21 rotavirus rotavirus JJ cord-303447-3a7jxl34 309 22 vaccine vaccine NN cord-303447-3a7jxl34 309 23 recommendation recommendation NN cord-303447-3a7jxl34 309 24 Rotavirus Rotavirus NNP cord-303447-3a7jxl34 309 25 vaccine vaccine NN cord-303447-3a7jxl34 309 26 for for IN cord-303447-3a7jxl34 309 27 the the DT cord-303447-3a7jxl34 309 28 prevention prevention NN cord-303447-3a7jxl34 309 29 of of IN cord-303447-3a7jxl34 309 30 rotavirus rotavirus JJ cord-303447-3a7jxl34 309 31 gastroenteritis gastroenteritis NN cord-303447-3a7jxl34 309 32 among among IN cord-303447-3a7jxl34 309 33 children child NNS cord-303447-3a7jxl34 309 34 : : : cord-303447-3a7jxl34 309 35 recommendations recommendation NNS cord-303447-3a7jxl34 309 36 of of IN cord-303447-3a7jxl34 309 37 the the DT cord-303447-3a7jxl34 309 38 Advisory Advisory NNP cord-303447-3a7jxl34 309 39 Committee Committee NNP cord-303447-3a7jxl34 309 40 on on IN cord-303447-3a7jxl34 309 41 Immunization Immunization NNP cord-303447-3a7jxl34 309 42 Practices Practices NNPS cord-303447-3a7jxl34 309 43 ( ( -LRB- cord-303447-3a7jxl34 309 44 ACIP ACIP NNP cord-303447-3a7jxl34 309 45 ) ) -RRB- cord-303447-3a7jxl34 309 46 Safety safety NN cord-303447-3a7jxl34 309 47 of of IN cord-303447-3a7jxl34 309 48 immunizations immunization NNS cord-303447-3a7jxl34 309 49 Centers Centers NNPS cord-303447-3a7jxl34 309 50 for for IN cord-303447-3a7jxl34 309 51 Disease Disease NNP cord-303447-3a7jxl34 309 52 Control Control NNP cord-303447-3a7jxl34 309 53 and and CC cord-303447-3a7jxl34 309 54 Prevention Prevention NNP cord-303447-3a7jxl34 309 55 . . . cord-303447-3a7jxl34 310 1 Immunization immunization NN cord-303447-3a7jxl34 310 2 of of IN cord-303447-3a7jxl34 310 3 adolescents adolescent NNS cord-303447-3a7jxl34 310 4 : : : cord-303447-3a7jxl34 310 5 recommendations recommendation NNS cord-303447-3a7jxl34 310 6 of of IN cord-303447-3a7jxl34 310 7 the the DT cord-303447-3a7jxl34 310 8 Advisory Advisory NNP cord-303447-3a7jxl34 310 9 Committee Committee NNP cord-303447-3a7jxl34 310 10 on on IN cord-303447-3a7jxl34 310 11 Immunization Immunization NNP cord-303447-3a7jxl34 310 12 Practices Practices NNPS cord-303447-3a7jxl34 310 13 , , , cord-303447-3a7jxl34 310 14 the the DT cord-303447-3a7jxl34 310 15 American American NNP cord-303447-3a7jxl34 310 16 Academy Academy NNP cord-303447-3a7jxl34 310 17 of of IN cord-303447-3a7jxl34 310 18 Pediatrics Pediatrics NNP cord-303447-3a7jxl34 310 19 , , , cord-303447-3a7jxl34 310 20 the the DT cord-303447-3a7jxl34 310 21 American American NNP cord-303447-3a7jxl34 310 22 Academy Academy NNP cord-303447-3a7jxl34 310 23 of of IN cord-303447-3a7jxl34 310 24 Family Family NNP cord-303447-3a7jxl34 310 25 Physicians Physicians NNPS cord-303447-3a7jxl34 310 26 , , , cord-303447-3a7jxl34 310 27 and and CC cord-303447-3a7jxl34 310 28 the the DT cord-303447-3a7jxl34 310 29 American American NNP cord-303447-3a7jxl34 310 30 Medical Medical NNP cord-303447-3a7jxl34 310 31 Association Association NNP cord-303447-3a7jxl34 310 32 Preventing prevent VBG cord-303447-3a7jxl34 310 33 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 310 34 disease disease NN cord-303447-3a7jxl34 310 35 among among IN cord-303447-3a7jxl34 310 36 infants infant NNS cord-303447-3a7jxl34 310 37 and and CC cord-303447-3a7jxl34 310 38 young young JJ cord-303447-3a7jxl34 310 39 children child NNS cord-303447-3a7jxl34 310 40 : : : cord-303447-3a7jxl34 310 41 recommendations recommendation NNS cord-303447-3a7jxl34 310 42 of of IN cord-303447-3a7jxl34 310 43 the the DT cord-303447-3a7jxl34 310 44 Advisory Advisory NNP cord-303447-3a7jxl34 310 45 Committee Committee NNP cord-303447-3a7jxl34 310 46 on on IN cord-303447-3a7jxl34 310 47 Immunization Immunization NNP cord-303447-3a7jxl34 310 48 Practices Practices NNPS cord-303447-3a7jxl34 310 49 ( ( -LRB- cord-303447-3a7jxl34 311 1 ACIP ACIP NNP cord-303447-3a7jxl34 311 2 ) ) -RRB- cord-303447-3a7jxl34 311 3 Postlicensure postlicensure NN cord-303447-3a7jxl34 311 4 surveillance surveillance NN cord-303447-3a7jxl34 311 5 for for IN cord-303447-3a7jxl34 311 6 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 311 7 invasive invasive JJ cord-303447-3a7jxl34 311 8 disease disease NN cord-303447-3a7jxl34 311 9 after after IN cord-303447-3a7jxl34 311 10 use use NN cord-303447-3a7jxl34 311 11 of of IN cord-303447-3a7jxl34 311 12 heptavalent heptavalent NN cord-303447-3a7jxl34 311 13 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 311 14 conjugate conjugate JJ cord-303447-3a7jxl34 311 15 vaccine vaccine NN cord-303447-3a7jxl34 311 16 in in IN cord-303447-3a7jxl34 311 17 Northern Northern NNP cord-303447-3a7jxl34 311 18 California California NNP cord-303447-3a7jxl34 311 19 Kaiser Kaiser NNP cord-303447-3a7jxl34 311 20 Permanente Permanente NNP cord-303447-3a7jxl34 311 21 Decrease Decrease NNP cord-303447-3a7jxl34 311 22 of of IN cord-303447-3a7jxl34 311 23 invasive invasive JJ cord-303447-3a7jxl34 311 24 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 311 25 infections infection NNS cord-303447-3a7jxl34 311 26 in in IN cord-303447-3a7jxl34 311 27 children child NNS cord-303447-3a7jxl34 311 28 among among IN cord-303447-3a7jxl34 311 29 8 8 CD cord-303447-3a7jxl34 311 30 children child NNS cord-303447-3a7jxl34 311 31 's 's POS cord-303447-3a7jxl34 311 32 hospitals hospital NNS cord-303447-3a7jxl34 311 33 in in IN cord-303447-3a7jxl34 311 34 the the DT cord-303447-3a7jxl34 311 35 United United NNP cord-303447-3a7jxl34 311 36 States States NNP cord-303447-3a7jxl34 311 37 after after IN cord-303447-3a7jxl34 311 38 the the DT cord-303447-3a7jxl34 311 39 introduction introduction NN cord-303447-3a7jxl34 311 40 of of IN cord-303447-3a7jxl34 311 41 the the DT cord-303447-3a7jxl34 311 42 7-valent 7-valent CD cord-303447-3a7jxl34 311 43 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 311 44 conjugate conjugate NN cord-303447-3a7jxl34 311 45 vaccine vaccine NN cord-303447-3a7jxl34 311 46 Decline decline VB cord-303447-3a7jxl34 311 47 in in IN cord-303447-3a7jxl34 311 48 invasive invasive JJ cord-303447-3a7jxl34 311 49 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 311 50 disease disease NN cord-303447-3a7jxl34 311 51 after after IN cord-303447-3a7jxl34 311 52 the the DT cord-303447-3a7jxl34 311 53 introduction introduction NN cord-303447-3a7jxl34 311 54 of of IN cord-303447-3a7jxl34 311 55 protein protein NN cord-303447-3a7jxl34 311 56 - - HYPH cord-303447-3a7jxl34 311 57 polysaccharide polysaccharide NN cord-303447-3a7jxl34 311 58 conjugate conjugate NN cord-303447-3a7jxl34 311 59 vaccine vaccine NN cord-303447-3a7jxl34 311 60 Population population NN cord-303447-3a7jxl34 311 61 - - HYPH cord-303447-3a7jxl34 311 62 based base VBN cord-303447-3a7jxl34 311 63 impact impact NN cord-303447-3a7jxl34 311 64 of of IN cord-303447-3a7jxl34 311 65 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 311 66 conjugate conjugate JJ cord-303447-3a7jxl34 311 67 vaccine vaccine NN cord-303447-3a7jxl34 311 68 in in IN cord-303447-3a7jxl34 311 69 young young JJ cord-303447-3a7jxl34 311 70 children child NNS cord-303447-3a7jxl34 311 71 Impact Impact NNP cord-303447-3a7jxl34 311 72 of of IN cord-303447-3a7jxl34 311 73 the the DT cord-303447-3a7jxl34 311 74 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 311 75 conjugate conjugate NN cord-303447-3a7jxl34 311 76 vaccine vaccine NN cord-303447-3a7jxl34 311 77 on on IN cord-303447-3a7jxl34 311 78 otitis otitis NN cord-303447-3a7jxl34 311 79 media medium NNS cord-303447-3a7jxl34 311 80 Pediatricians pediatrician NNS cord-303447-3a7jxl34 311 81 ' ' POS cord-303447-3a7jxl34 311 82 self self NN cord-303447-3a7jxl34 311 83 - - HYPH cord-303447-3a7jxl34 311 84 reported report VBN cord-303447-3a7jxl34 311 85 clinical clinical JJ cord-303447-3a7jxl34 311 86 practices practice NNS cord-303447-3a7jxl34 311 87 and and CC cord-303447-3a7jxl34 311 88 adherence adherence NN cord-303447-3a7jxl34 311 89 to to IN cord-303447-3a7jxl34 311 90 national national JJ cord-303447-3a7jxl34 311 91 immunization immunization NN cord-303447-3a7jxl34 311 92 guidelines guideline NNS cord-303447-3a7jxl34 311 93 after after IN cord-303447-3a7jxl34 311 94 the the DT cord-303447-3a7jxl34 311 95 introduction introduction NN cord-303447-3a7jxl34 311 96 of of IN cord-303447-3a7jxl34 311 97 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 311 98 conjugate conjugate NN cord-303447-3a7jxl34 311 99 vaccine vaccine NN cord-303447-3a7jxl34 311 100 Potential potential JJ cord-303447-3a7jxl34 311 101 impact impact NN cord-303447-3a7jxl34 311 102 of of IN cord-303447-3a7jxl34 311 103 conjugate conjugate JJ cord-303447-3a7jxl34 311 104 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 311 105 vaccines vaccine NNS cord-303447-3a7jxl34 311 106 on on IN cord-303447-3a7jxl34 311 107 pediatric pediatric JJ cord-303447-3a7jxl34 311 108 pneumococcal pneumococcal JJ cord-303447-3a7jxl34 311 109 diseases disease NNS cord-303447-3a7jxl34 311 110 Childhood Childhood NNP cord-303447-3a7jxl34 311 111 hepatitis hepatitis NN cord-303447-3a7jxl34 311 112 B B NNP cord-303447-3a7jxl34 311 113 virus virus NN cord-303447-3a7jxl34 311 114 infections infection NNS cord-303447-3a7jxl34 311 115 in in IN cord-303447-3a7jxl34 311 116 the the DT cord-303447-3a7jxl34 311 117 United United NNP cord-303447-3a7jxl34 311 118 States States NNP cord-303447-3a7jxl34 311 119 before before IN cord-303447-3a7jxl34 311 120 hepatitis hepatitis NNP cord-303447-3a7jxl34 311 121 B B NNP cord-303447-3a7jxl34 311 122 immunization immunization NN cord-303447-3a7jxl34 311 123 Clinical clinical JJ cord-303447-3a7jxl34 311 124 practice practice NN cord-303447-3a7jxl34 311 125 : : : cord-303447-3a7jxl34 311 126 prevention prevention NN cord-303447-3a7jxl34 311 127 of of IN cord-303447-3a7jxl34 311 128 hepatitis hepatitis NNP cord-303447-3a7jxl34 311 129 B B NNP cord-303447-3a7jxl34 311 130 with with IN cord-303447-3a7jxl34 311 131 the the DT cord-303447-3a7jxl34 311 132 hepatitis hepatitis NN cord-303447-3a7jxl34 311 133 B B NNP cord-303447-3a7jxl34 311 134 vaccine vaccine NN cord-303447-3a7jxl34 311 135 Centers Centers NNPS cord-303447-3a7jxl34 311 136 for for IN cord-303447-3a7jxl34 311 137 Disease Disease NNP cord-303447-3a7jxl34 311 138 Control Control NNP cord-303447-3a7jxl34 311 139 and and CC cord-303447-3a7jxl34 311 140 Prevention Prevention NNP cord-303447-3a7jxl34 311 141 . . . cord-303447-3a7jxl34 312 1 Hepatitis Hepatitis NNP cord-303447-3a7jxl34 312 2 B B NNP cord-303447-3a7jxl34 312 3 vaccination vaccination NN cord-303447-3a7jxl34 312 4 - - : cord-303447-3a7jxl34 312 5 United United NNP cord-303447-3a7jxl34 312 6 States States NNP cord-303447-3a7jxl34 312 7 Acute acute JJ cord-303447-3a7jxl34 312 8 hepatitis hepatitis NN cord-303447-3a7jxl34 312 9 B b NN cord-303447-3a7jxl34 312 10 among among IN cord-303447-3a7jxl34 312 11 children child NNS cord-303447-3a7jxl34 312 12 and and CC cord-303447-3a7jxl34 312 13 adolescents adolescent NNS cord-303447-3a7jxl34 312 14 - - : cord-303447-3a7jxl34 312 15 United United NNP cord-303447-3a7jxl34 312 16 States States NNP cord-303447-3a7jxl34 312 17 Opportunities Opportunities NNPS cord-303447-3a7jxl34 312 18 for for IN cord-303447-3a7jxl34 312 19 control control NN cord-303447-3a7jxl34 312 20 of of IN cord-303447-3a7jxl34 312 21 meningococcal meningococcal JJ cord-303447-3a7jxl34 312 22 disease disease NN cord-303447-3a7jxl34 312 23 in in IN cord-303447-3a7jxl34 312 24 the the DT cord-303447-3a7jxl34 312 25 US US NNP cord-303447-3a7jxl34 312 26 Prevention Prevention NNP cord-303447-3a7jxl34 312 27 and and CC cord-303447-3a7jxl34 312 28 control control NN cord-303447-3a7jxl34 312 29 of of IN cord-303447-3a7jxl34 312 30 meningococcal meningococcal JJ cord-303447-3a7jxl34 312 31 disease disease NN cord-303447-3a7jxl34 312 32 and and CC cord-303447-3a7jxl34 312 33 meningococcal meningococcal JJ cord-303447-3a7jxl34 312 34 disease disease NN cord-303447-3a7jxl34 312 35 and and CC cord-303447-3a7jxl34 312 36 college college NN cord-303447-3a7jxl34 312 37 students student NNS cord-303447-3a7jxl34 312 38 : : : cord-303447-3a7jxl34 312 39 recommendations recommendation NNS cord-303447-3a7jxl34 312 40 of of IN cord-303447-3a7jxl34 312 41 the the DT cord-303447-3a7jxl34 312 42 Advisory Advisory NNP cord-303447-3a7jxl34 312 43 Committee Committee NNP cord-303447-3a7jxl34 312 44 on on IN cord-303447-3a7jxl34 312 45 Immunization Immunization NNP cord-303447-3a7jxl34 312 46 Practices Practices NNPS cord-303447-3a7jxl34 312 47 ( ( -LRB- cord-303447-3a7jxl34 312 48 ACIP ACIP NNP cord-303447-3a7jxl34 312 49 ) ) -RRB- cord-303447-3a7jxl34 312 50 Active Active NNP cord-303447-3a7jxl34 312 51 Bacterial Bacterial NNP cord-303447-3a7jxl34 312 52 Core Core NNP cord-303447-3a7jxl34 312 53 Surveillance Surveillance NNP cord-303447-3a7jxl34 312 54 Report Report NNP cord-303447-3a7jxl34 312 55 , , , cord-303447-3a7jxl34 312 56 Emerging Emerging NNP cord-303447-3a7jxl34 312 57 Infections Infections NNPS cord-303447-3a7jxl34 312 58 Program Program NNP cord-303447-3a7jxl34 312 59 Network Network NNP cord-303447-3a7jxl34 312 60 Changing change VBG cord-303447-3a7jxl34 312 61 epidemiology epidemiology NN cord-303447-3a7jxl34 312 62 of of IN cord-303447-3a7jxl34 312 63 pertussis pertussis NN cord-303447-3a7jxl34 312 64 in in IN cord-303447-3a7jxl34 312 65 the the DT cord-303447-3a7jxl34 312 66 United United NNP cord-303447-3a7jxl34 312 67 States States NNP cord-303447-3a7jxl34 312 68 : : : cord-303447-3a7jxl34 312 69 increasing increase VBG cord-303447-3a7jxl34 312 70 reported report VBN cord-303447-3a7jxl34 312 71 incidence incidence NN cord-303447-3a7jxl34 312 72 among among IN cord-303447-3a7jxl34 312 73 adolescents adolescent NNS cord-303447-3a7jxl34 312 74 and and CC cord-303447-3a7jxl34 312 75 adults adult NNS cord-303447-3a7jxl34 313 1 Final final JJ cord-303447-3a7jxl34 313 2 : : : cord-303447-3a7jxl34 314 1 2003 2003 CD cord-303447-3a7jxl34 314 2 reports report NNS cord-303447-3a7jxl34 314 3 of of IN cord-303447-3a7jxl34 314 4 notifiable notifiable JJ cord-303447-3a7jxl34 314 5 diseases disease NNS cord-303447-3a7jxl34 314 6 Trends trend NNS cord-303447-3a7jxl34 314 7 in in IN cord-303447-3a7jxl34 314 8 pertussis pertussis NN cord-303447-3a7jxl34 314 9 among among IN cord-303447-3a7jxl34 314 10 infants infant NNS cord-303447-3a7jxl34 314 11 in in IN cord-303447-3a7jxl34 314 12 the the DT cord-303447-3a7jxl34 314 13 United United NNP cord-303447-3a7jxl34 314 14 States States NNP cord-303447-3a7jxl34 314 15 Societal Societal NNP cord-303447-3a7jxl34 314 16 costs cost NNS cord-303447-3a7jxl34 314 17 and and CC cord-303447-3a7jxl34 314 18 morbidity morbidity NN cord-303447-3a7jxl34 314 19 of of IN cord-303447-3a7jxl34 314 20 pertussis pertussis NN cord-303447-3a7jxl34 314 21 in in IN cord-303447-3a7jxl34 314 22 adolescents adolescent NNS cord-303447-3a7jxl34 314 23 and and CC cord-303447-3a7jxl34 314 24 adults adult NNS cord-303447-3a7jxl34 314 25 Morbidity morbidity NN cord-303447-3a7jxl34 314 26 of of IN cord-303447-3a7jxl34 314 27 pertussis pertussis NN cord-303447-3a7jxl34 314 28 in in IN cord-303447-3a7jxl34 314 29 adolescents adolescent NNS cord-303447-3a7jxl34 314 30 and and CC cord-303447-3a7jxl34 314 31 adults adult NNS cord-303447-3a7jxl34 314 32 Evaluation Evaluation NNP cord-303447-3a7jxl34 314 33 of of IN cord-303447-3a7jxl34 314 34 strategies strategy NNS cord-303447-3a7jxl34 314 35 for for IN cord-303447-3a7jxl34 314 36 use use NN cord-303447-3a7jxl34 314 37 of of IN cord-303447-3a7jxl34 314 38 acellular acellular JJ cord-303447-3a7jxl34 314 39 pertussis pertussis NN cord-303447-3a7jxl34 314 40 vaccine vaccine NN cord-303447-3a7jxl34 314 41 in in IN cord-303447-3a7jxl34 314 42 adolescents adolescent NNS cord-303447-3a7jxl34 314 43 and and CC cord-303447-3a7jxl34 314 44 adults adult NNS cord-303447-3a7jxl34 314 45 : : : cord-303447-3a7jxl34 315 1 a a DT cord-303447-3a7jxl34 315 2 cost cost NN cord-303447-3a7jxl34 315 3 - - HYPH cord-303447-3a7jxl34 315 4 benefit benefit NN cord-303447-3a7jxl34 315 5 analysis analysis NN cord-303447-3a7jxl34 315 6 Infant infant NN cord-303447-3a7jxl34 315 7 pertussis pertussis NN cord-303447-3a7jxl34 315 8 : : : cord-303447-3a7jxl34 316 1 who who WP cord-303447-3a7jxl34 316 2 was be VBD cord-303447-3a7jxl34 316 3 the the DT cord-303447-3a7jxl34 316 4 source source NN cord-303447-3a7jxl34 316 5 ? ? . cord-303447-3a7jxl34 317 1 New new JJ cord-303447-3a7jxl34 317 2 pertussis pertussis NN cord-303447-3a7jxl34 317 3 vaccination vaccination NN cord-303447-3a7jxl34 317 4 strategies strategy NNS cord-303447-3a7jxl34 317 5 beyond beyond IN cord-303447-3a7jxl34 317 6 infancy infancy NN cord-303447-3a7jxl34 317 7 : : : cord-303447-3a7jxl34 317 8 recommendations recommendation NNS cord-303447-3a7jxl34 317 9 by by IN cord-303447-3a7jxl34 317 10 the the DT cord-303447-3a7jxl34 317 11 global global JJ cord-303447-3a7jxl34 317 12 pertussis pertussis NN cord-303447-3a7jxl34 317 13 initiative initiative NN cord-303447-3a7jxl34 317 14 Pertussis pertussis NN cord-303447-3a7jxl34 317 15 vaccination vaccination NN cord-303447-3a7jxl34 317 16 strategies strategy NNS cord-303447-3a7jxl34 317 17 for for IN cord-303447-3a7jxl34 317 18 neonates neonate NNS cord-303447-3a7jxl34 317 19 - - : cord-303447-3a7jxl34 317 20 an an DT cord-303447-3a7jxl34 317 21 exploratory exploratory JJ cord-303447-3a7jxl34 317 22 costeffectiveness costeffectiveness NN cord-303447-3a7jxl34 317 23 analysis analysis NN cord-303447-3a7jxl34 317 24 Human human JJ cord-303447-3a7jxl34 317 25 papillomavirus papillomavirus NN cord-303447-3a7jxl34 317 26 and and CC cord-303447-3a7jxl34 317 27 cervical cervical JJ cord-303447-3a7jxl34 317 28 cancer cancer NN cord-303447-3a7jxl34 317 29 Safety safety NN cord-303447-3a7jxl34 317 30 and and CC cord-303447-3a7jxl34 317 31 immunogenicity immunogenicity NN cord-303447-3a7jxl34 317 32 trial trial NN cord-303447-3a7jxl34 317 33 in in IN cord-303447-3a7jxl34 317 34 adult adult NN cord-303447-3a7jxl34 317 35 volunteers volunteer NNS cord-303447-3a7jxl34 317 36 of of IN cord-303447-3a7jxl34 317 37 a a DT cord-303447-3a7jxl34 317 38 human human JJ cord-303447-3a7jxl34 317 39 papillomavirus papillomavirus NN cord-303447-3a7jxl34 317 40 16 16 CD cord-303447-3a7jxl34 317 41 L1 L1 NNP cord-303447-3a7jxl34 317 42 virus virus NN cord-303447-3a7jxl34 317 43 - - HYPH cord-303447-3a7jxl34 317 44 like like JJ cord-303447-3a7jxl34 317 45 particle particle NN cord-303447-3a7jxl34 317 46 vaccine vaccine NN cord-303447-3a7jxl34 317 47 A a DT cord-303447-3a7jxl34 317 48 controlled control VBN cord-303447-3a7jxl34 317 49 trial trial NN cord-303447-3a7jxl34 317 50 of of IN cord-303447-3a7jxl34 317 51 a a DT cord-303447-3a7jxl34 317 52 human human JJ cord-303447-3a7jxl34 317 53 papillomavirus papillomavirus NN cord-303447-3a7jxl34 317 54 type type NN cord-303447-3a7jxl34 317 55 16 16 CD cord-303447-3a7jxl34 317 56 vaccine vaccine NN cord-303447-3a7jxl34 317 57 Efficacy Efficacy NNP cord-303447-3a7jxl34 317 58 of of IN cord-303447-3a7jxl34 317 59 a a DT cord-303447-3a7jxl34 317 60 bivalent bivalent JJ cord-303447-3a7jxl34 317 61 L1 L1 NNP cord-303447-3a7jxl34 317 62 virus virus NN cord-303447-3a7jxl34 317 63 - - : cord-303447-3a7jxl34 317 64 like like JJ cord-303447-3a7jxl34 317 65 particle particle NN cord-303447-3a7jxl34 317 66 vaccine vaccine NN cord-303447-3a7jxl34 317 67 in in IN cord-303447-3a7jxl34 317 68 prevention prevention NN cord-303447-3a7jxl34 317 69 of of IN cord-303447-3a7jxl34 317 70 infection infection NN cord-303447-3a7jxl34 317 71 with with IN cord-303447-3a7jxl34 317 72 human human JJ cord-303447-3a7jxl34 317 73 papillomavirus papillomavirus NN cord-303447-3a7jxl34 317 74 types type NNS cord-303447-3a7jxl34 317 75 16 16 CD cord-303447-3a7jxl34 317 76 and and CC cord-303447-3a7jxl34 317 77 18 18 CD cord-303447-3a7jxl34 317 78 in in IN cord-303447-3a7jxl34 317 79 young young JJ cord-303447-3a7jxl34 317 80 women woman NNS cord-303447-3a7jxl34 317 81 : : : cord-303447-3a7jxl34 317 82 a a DT cord-303447-3a7jxl34 317 83 randomised randomised JJ cord-303447-3a7jxl34 317 84 controlled control VBN cord-303447-3a7jxl34 317 85 trial trial NN cord-303447-3a7jxl34 317 86 Intussusception Intussusception NNP cord-303447-3a7jxl34 317 87 among among IN cord-303447-3a7jxl34 317 88 recipients recipient NNS cord-303447-3a7jxl34 317 89 of of IN cord-303447-3a7jxl34 317 90 rotavirus rotavirus JJ cord-303447-3a7jxl34 317 91 vaccine vaccine NN cord-303447-3a7jxl34 317 92 : : : cord-303447-3a7jxl34 317 93 reports report NNS cord-303447-3a7jxl34 317 94 to to IN cord-303447-3a7jxl34 317 95 the the DT cord-303447-3a7jxl34 317 96 Vaccine Vaccine NNP cord-303447-3a7jxl34 317 97 Adverse Adverse NNP cord-303447-3a7jxl34 317 98 Event Event NNP cord-303447-3a7jxl34 317 99 Reporting Reporting NNP cord-303447-3a7jxl34 317 100 System System NNP cord-303447-3a7jxl34 317 101 Intussusception Intussusception NNP cord-303447-3a7jxl34 317 102 among among IN cord-303447-3a7jxl34 317 103 infants infant NNS cord-303447-3a7jxl34 317 104 given give VBN cord-303447-3a7jxl34 317 105 an an DT cord-303447-3a7jxl34 317 106 oral oral JJ cord-303447-3a7jxl34 317 107 rotavirus rotavirus JJ cord-303447-3a7jxl34 317 108 vaccine vaccine NN cord-303447-3a7jxl34 317 109 Available available JJ cord-303447-3a7jxl34 317 110 at at IN cord-303447-3a7jxl34 317 111 : : : cord-303447-3a7jxl34 317 112 www.pediatrics www.pediatrics NNP cord-303447-3a7jxl34 317 113 . . . cord-303447-3a7jxl34 318 1 aappublications.org/cgi/reprint/112/1/e6?maxtoshow=&HITS=10&hits=10&RESULTFORMAT= aappublications.org/cgi/reprint/112/1/e6?maxtoshow=&HITS=10&hits=10&RESULTFORMAT= NNP cord-303447-3a7jxl34 318 2 & & CC cord-303447-3a7jxl34 318 3 author1= author1= NNP cord-303447-3a7jxl34 319 1 Iwamoto&searchid=1107975380001_13871&stored_search=&FIRSTINDEX=0&sortspec= Iwamoto&searchid=1107975380001_13871&stored_search=&FIRSTINDEX=0&sortspec= NNS cord-303447-3a7jxl34 320 1 relevance&journalcode= relevance&journalcode= NNP cord-303447-3a7jxl34 321 1 pediatrics pediatrics NNP cord-303447-3a7jxl34 321 2 Varicella Varicella NNP cord-303447-3a7jxl34 321 3 disease disease NN cord-303447-3a7jxl34 321 4 after after IN cord-303447-3a7jxl34 321 5 introduction introduction NN cord-303447-3a7jxl34 321 6 of of IN cord-303447-3a7jxl34 321 7 varicella varicella NN cord-303447-3a7jxl34 321 8 vaccine vaccine NN cord-303447-3a7jxl34 321 9 in in IN cord-303447-3a7jxl34 321 10 the the DT cord-303447-3a7jxl34 321 11 United United NNP cord-303447-3a7jxl34 321 12 States States NNP cord-303447-3a7jxl34 321 13 Contagiousness Contagiousness NNP cord-303447-3a7jxl34 321 14 of of IN cord-303447-3a7jxl34 321 15 varicella varicella NN cord-303447-3a7jxl34 321 16 in in IN cord-303447-3a7jxl34 321 17 vaccinated vaccinated JJ cord-303447-3a7jxl34 321 18 cases case NNS cord-303447-3a7jxl34 321 19 : : : cord-303447-3a7jxl34 321 20 a a DT cord-303447-3a7jxl34 321 21 household household NN cord-303447-3a7jxl34 321 22 contact contact NN cord-303447-3a7jxl34 321 23 study study NN cord-303447-3a7jxl34 321 24 Contacts contact NNS cord-303447-3a7jxl34 321 25 with with IN cord-303447-3a7jxl34 321 26 varicella varicella NN cord-303447-3a7jxl34 321 27 or or CC cord-303447-3a7jxl34 321 28 with with IN cord-303447-3a7jxl34 321 29 children child NNS cord-303447-3a7jxl34 321 30 and and CC cord-303447-3a7jxl34 321 31 protection protection NN cord-303447-3a7jxl34 321 32 against against IN cord-303447-3a7jxl34 321 33 herpes herpes NNP cord-303447-3a7jxl34 321 34 zoster zoster NN cord-303447-3a7jxl34 321 35 in in IN cord-303447-3a7jxl34 321 36 adults adult NNS cord-303447-3a7jxl34 321 37 : : : cord-303447-3a7jxl34 321 38 a a DT cord-303447-3a7jxl34 321 39 case case NN cord-303447-3a7jxl34 321 40 - - HYPH cord-303447-3a7jxl34 321 41 control control NN cord-303447-3a7jxl34 321 42 study study NN cord-303447-3a7jxl34 321 43 Influenza Influenza NNP cord-303447-3a7jxl34 321 44 - - HYPH cord-303447-3a7jxl34 321 45 associated associate VBN cord-303447-3a7jxl34 321 46 hospitalizations hospitalization NNS cord-303447-3a7jxl34 321 47 in in IN cord-303447-3a7jxl34 321 48 the the DT cord-303447-3a7jxl34 321 49 United United NNP cord-303447-3a7jxl34 321 50 States States NNP cord-303447-3a7jxl34 321 51 Enhanced Enhanced NNP cord-303447-3a7jxl34 321 52 virulence virulence NN cord-303447-3a7jxl34 321 53 of of IN cord-303447-3a7jxl34 321 54 influenza influenza NN cord-303447-3a7jxl34 321 55 A a DT cord-303447-3a7jxl34 321 56 viruses virus NNS cord-303447-3a7jxl34 321 57 with with IN cord-303447-3a7jxl34 321 58 the the DT cord-303447-3a7jxl34 321 59 haemagglutinin haemagglutinin NNP cord-303447-3a7jxl34 321 60 of of IN cord-303447-3a7jxl34 321 61 the the DT cord-303447-3a7jxl34 321 62 1918 1918 CD cord-303447-3a7jxl34 321 63 pandemic pandemic NN cord-303447-3a7jxl34 321 64 virus virus NN cord-303447-3a7jxl34 321 65 Risk risk NN cord-303447-3a7jxl34 321 66 factors factor NNS cord-303447-3a7jxl34 321 67 associated associate VBN cord-303447-3a7jxl34 321 68 with with IN cord-303447-3a7jxl34 321 69 severe severe JJ cord-303447-3a7jxl34 321 70 influenza influenza NN cord-303447-3a7jxl34 321 71 infections infection NNS cord-303447-3a7jxl34 321 72 in in IN cord-303447-3a7jxl34 321 73 childhood childhood NN cord-303447-3a7jxl34 321 74 : : : cord-303447-3a7jxl34 321 75 implication implication NN cord-303447-3a7jxl34 321 76 for for IN cord-303447-3a7jxl34 321 77 vaccine vaccine NN cord-303447-3a7jxl34 321 78 strategy strategy NN cord-303447-3a7jxl34 321 79 Burden Burden NNP cord-303447-3a7jxl34 321 80 of of IN cord-303447-3a7jxl34 321 81 interpandemic interpandemic JJ cord-303447-3a7jxl34 321 82 influenza influenza NN cord-303447-3a7jxl34 321 83 in in IN cord-303447-3a7jxl34 321 84 children child NNS cord-303447-3a7jxl34 321 85 younger young JJR cord-303447-3a7jxl34 321 86 than than IN cord-303447-3a7jxl34 321 87 5 5 CD cord-303447-3a7jxl34 321 88 years year NNS cord-303447-3a7jxl34 321 89 : : : cord-303447-3a7jxl34 321 90 a a DT cord-303447-3a7jxl34 321 91 25-year 25-year JJ cord-303447-3a7jxl34 321 92 prospective prospective JJ cord-303447-3a7jxl34 321 93 prospective prospective JJ cord-303447-3a7jxl34 321 94 study study NN cord-303447-3a7jxl34 321 95 Influenza Influenza NNP cord-303447-3a7jxl34 321 96 and and CC cord-303447-3a7jxl34 321 97 the the DT cord-303447-3a7jxl34 321 98 rates rate NNS cord-303447-3a7jxl34 321 99 of of IN cord-303447-3a7jxl34 321 100 hospitalization hospitalization NN cord-303447-3a7jxl34 321 101 for for IN cord-303447-3a7jxl34 321 102 respiratory respiratory JJ cord-303447-3a7jxl34 321 103 disease disease NN cord-303447-3a7jxl34 321 104 among among IN cord-303447-3a7jxl34 321 105 infants infant NNS cord-303447-3a7jxl34 321 106 and and CC cord-303447-3a7jxl34 321 107 young young JJ cord-303447-3a7jxl34 321 108 children child NNS cord-303447-3a7jxl34 321 109 Centers Centers NNPS cord-303447-3a7jxl34 321 110 for for IN cord-303447-3a7jxl34 321 111 Disease Disease NNP cord-303447-3a7jxl34 321 112 Control Control NNP cord-303447-3a7jxl34 321 113 and and CC cord-303447-3a7jxl34 321 114 Prevention Prevention NNP cord-303447-3a7jxl34 321 115 . . . cord-303447-3a7jxl34 322 1 Prevention prevention NN cord-303447-3a7jxl34 322 2 and and CC cord-303447-3a7jxl34 322 3 control control NN cord-303447-3a7jxl34 322 4 of of IN cord-303447-3a7jxl34 322 5 influenza influenza NN cord-303447-3a7jxl34 322 6 : : : cord-303447-3a7jxl34 322 7 recommendations recommendation NNS cord-303447-3a7jxl34 322 8 of of IN cord-303447-3a7jxl34 322 9 the the DT cord-303447-3a7jxl34 322 10 Advisory Advisory NNP cord-303447-3a7jxl34 322 11 Committee Committee NNP cord-303447-3a7jxl34 322 12 on on IN cord-303447-3a7jxl34 322 13 Immunization Immunization NNP cord-303447-3a7jxl34 322 14 Practices Practices NNPS cord-303447-3a7jxl34 323 1 ( ( -LRB- cord-303447-3a7jxl34 323 2 ACIP ACIP NNP cord-303447-3a7jxl34 323 3 ) ) -RRB- cord-303447-3a7jxl34 323 4 Update update NN cord-303447-3a7jxl34 323 5 : : : cord-303447-3a7jxl34 324 1 influenza influenza NN cord-303447-3a7jxl34 324 2 - - HYPH cord-303447-3a7jxl34 324 3 associated associate VBN cord-303447-3a7jxl34 324 4 deaths death NNS cord-303447-3a7jxl34 324 5 reported report VBN cord-303447-3a7jxl34 324 6 among among IN cord-303447-3a7jxl34 324 7 children child NNS cord-303447-3a7jxl34 324 8 aged age VBN cord-303447-3a7jxl34 324 9 b b NN cord-303447-3a7jxl34 324 10 18 18 CD cord-303447-3a7jxl34 324 11 years year NNS cord-303447-3a7jxl34 324 12 - - : cord-303447-3a7jxl34 324 13 United United NNP cord-303447-3a7jxl34 324 14 States States NNP cord-303447-3a7jxl34 324 15 , , , cord-303447-3a7jxl34 324 16 2003 2003 CD cord-303447-3a7jxl34 324 17 - - SYM cord-303447-3a7jxl34 324 18 04 04 CD cord-303447-3a7jxl34 325 1 influenza influenza NN cord-303447-3a7jxl34 325 2 season season NNP cord-303447-3a7jxl34 325 3 Vaccine Vaccine NNP cord-303447-3a7jxl34 325 4 technologies technology NNS cord-303447-3a7jxl34 325 5 Progress Progress NNP cord-303447-3a7jxl34 325 6 in in IN cord-303447-3a7jxl34 325 7 immunologic immunologic JJ cord-303447-3a7jxl34 325 8 adjuvant adjuvant NN cord-303447-3a7jxl34 325 9 development development NN cord-303447-3a7jxl34 325 10 Financing financing NN cord-303447-3a7jxl34 325 11 vaccines vaccine NNS cord-303447-3a7jxl34 325 12 in in IN cord-303447-3a7jxl34 325 13 the the DT cord-303447-3a7jxl34 325 14 21st 21st JJ cord-303447-3a7jxl34 325 15 century century NN cord-303447-3a7jxl34 325 16 : : : cord-303447-3a7jxl34 326 1 assuring assure VBG cord-303447-3a7jxl34 326 2 access access NN cord-303447-3a7jxl34 326 3 and and CC cord-303447-3a7jxl34 326 4 availability availability NN cord-303447-3a7jxl34 326 5 Genesis Genesis NNP cord-303447-3a7jxl34 326 6 of of IN cord-303447-3a7jxl34 326 7 a a DT cord-303447-3a7jxl34 326 8 highly highly RB cord-303447-3a7jxl34 326 9 pathogenic pathogenic JJ cord-303447-3a7jxl34 326 10 and and CC cord-303447-3a7jxl34 326 11 potentially potentially RB cord-303447-3a7jxl34 326 12 pandemic pandemic JJ cord-303447-3a7jxl34 326 13 H5N1 H5N1 NNP cord-303447-3a7jxl34 326 14 influenza influenza NN cord-303447-3a7jxl34 326 15 virus virus NN cord-303447-3a7jxl34 326 16 in in IN cord-303447-3a7jxl34 326 17 eastern eastern JJ cord-303447-3a7jxl34 326 18 Asia Asia NNP