id sid tid token lemma pos cord-262892-n38r8n70 1 1 key key NN cord-262892-n38r8n70 1 2 : : : cord-262892-n38r8n70 1 3 cord-262892-n38r8n70 cord-262892-n38r8n70 JJ cord-262892-n38r8n70 1 4 authors author NNS cord-262892-n38r8n70 1 5 : : : cord-262892-n38r8n70 1 6 Sheikh Sheikh NNP cord-262892-n38r8n70 1 7 , , , cord-262892-n38r8n70 1 8 Jamila Jamila NNP cord-262892-n38r8n70 1 9 ; ; : cord-262892-n38r8n70 2 1 Wynn Wynn NNP cord-262892-n38r8n70 2 2 , , , cord-262892-n38r8n70 2 3 Bridget Bridget NNP cord-262892-n38r8n70 2 4 A. A. NNP cord-262892-n38r8n70 2 5 ; ; : cord-262892-n38r8n70 2 6 Chakraborty Chakraborty NNP cord-262892-n38r8n70 2 7 , , , cord-262892-n38r8n70 2 8 Rana Rana NNP cord-262892-n38r8n70 2 9 title title NN cord-262892-n38r8n70 2 10 : : : cord-262892-n38r8n70 2 11 Nutritional Nutritional NNP cord-262892-n38r8n70 2 12 Care Care NNP cord-262892-n38r8n70 2 13 of of IN cord-262892-n38r8n70 2 14 the the DT cord-262892-n38r8n70 2 15 Child child NN cord-262892-n38r8n70 2 16 with with IN cord-262892-n38r8n70 2 17 Human Human NNP cord-262892-n38r8n70 2 18 Immunodeficiency Immunodeficiency NNP cord-262892-n38r8n70 2 19 Virus Virus NNP cord-262892-n38r8n70 2 20 Infection Infection NNP cord-262892-n38r8n70 2 21 in in IN cord-262892-n38r8n70 2 22 the the DT cord-262892-n38r8n70 2 23 United United NNP cord-262892-n38r8n70 2 24 States States NNP cord-262892-n38r8n70 2 25 : : : cord-262892-n38r8n70 3 1 A a DT cord-262892-n38r8n70 3 2 Historical historical JJ cord-262892-n38r8n70 3 3 and and CC cord-262892-n38r8n70 3 4 Contemporary Contemporary NNP cord-262892-n38r8n70 3 5 Perspective Perspective NNP cord-262892-n38r8n70 3 6 date date NN cord-262892-n38r8n70 3 7 : : : cord-262892-n38r8n70 3 8 2015 2015 CD cord-262892-n38r8n70 3 9 - - HYPH cord-262892-n38r8n70 3 10 05 05 CD cord-262892-n38r8n70 3 11 - - HYPH cord-262892-n38r8n70 3 12 08 08 CD cord-262892-n38r8n70 3 13 journal journal NN cord-262892-n38r8n70 3 14 : : : cord-262892-n38r8n70 3 15 Health Health NNP cord-262892-n38r8n70 3 16 of of IN cord-262892-n38r8n70 3 17 HIV HIV NNP cord-262892-n38r8n70 3 18 Infected Infected NNP cord-262892-n38r8n70 3 19 People People NNPS cord-262892-n38r8n70 3 20 DOI DOI NNP cord-262892-n38r8n70 3 21 : : : cord-262892-n38r8n70 3 22 10.1016 10.1016 CD cord-262892-n38r8n70 3 23 / / SYM cord-262892-n38r8n70 3 24 b978 b978 NN cord-262892-n38r8n70 3 25 - - HYPH cord-262892-n38r8n70 3 26 0 0 CD cord-262892-n38r8n70 3 27 - - HYPH cord-262892-n38r8n70 3 28 12 12 CD cord-262892-n38r8n70 3 29 - - HYPH cord-262892-n38r8n70 3 30 800769 800769 CD cord-262892-n38r8n70 3 31 - - HYPH cord-262892-n38r8n70 3 32 3.00009 3.00009 CD cord-262892-n38r8n70 3 33 - - SYM cord-262892-n38r8n70 3 34 3 3 CD cord-262892-n38r8n70 3 35 sha sha NNP cord-262892-n38r8n70 3 36 : : : cord-262892-n38r8n70 3 37 10311f1cc4dcc7f690cb3b22560aae659ce1d436 10311f1cc4dcc7f690cb3b22560aae659ce1d436 CD cord-262892-n38r8n70 3 38 doc_id doc_id CD cord-262892-n38r8n70 3 39 : : : cord-262892-n38r8n70 3 40 262892 262892 CD cord-262892-n38r8n70 3 41 cord_uid cord_uid NNS cord-262892-n38r8n70 3 42 : : : cord-262892-n38r8n70 4 1 n38r8n70 n38r8n70 . cord-262892-n38r8n70 5 1 In in IN cord-262892-n38r8n70 5 2 well well RB cord-262892-n38r8n70 5 3 - - HYPH cord-262892-n38r8n70 5 4 resourced resource VBN cord-262892-n38r8n70 5 5 settings setting NNS cord-262892-n38r8n70 5 6 , , , cord-262892-n38r8n70 5 7 early early JJ cord-262892-n38r8n70 5 8 infant infant NN cord-262892-n38r8n70 5 9 diagnosis diagnosis NN cord-262892-n38r8n70 5 10 and and CC cord-262892-n38r8n70 5 11 administration administration NN cord-262892-n38r8n70 5 12 of of IN cord-262892-n38r8n70 5 13 life life NN cord-262892-n38r8n70 5 14 - - HYPH cord-262892-n38r8n70 5 15 saving save VBG cord-262892-n38r8n70 5 16 antiretrovirals antiretroviral NNS cord-262892-n38r8n70 5 17 ( ( -LRB- cord-262892-n38r8n70 5 18 ARVs arv NNS cord-262892-n38r8n70 5 19 ) ) -RRB- cord-262892-n38r8n70 5 20 have have VBP cord-262892-n38r8n70 5 21 significantly significantly RB cord-262892-n38r8n70 5 22 improved improve VBN cord-262892-n38r8n70 5 23 clinical clinical JJ cord-262892-n38r8n70 5 24 outcomes outcome NNS cord-262892-n38r8n70 5 25 in in IN cord-262892-n38r8n70 5 26 pediatric pediatric JJ cord-262892-n38r8n70 5 27 human human JJ cord-262892-n38r8n70 5 28 immunodeficiency immunodeficiency NN cord-262892-n38r8n70 5 29 virus virus NN cord-262892-n38r8n70 5 30 ( ( -LRB- cord-262892-n38r8n70 5 31 HIV HIV NNP cord-262892-n38r8n70 5 32 ) ) -RRB- cord-262892-n38r8n70 5 33 infection infection NN cord-262892-n38r8n70 5 34 . . . cord-262892-n38r8n70 6 1 The the DT cord-262892-n38r8n70 6 2 dramatic dramatic JJ cord-262892-n38r8n70 6 3 increase increase NN cord-262892-n38r8n70 6 4 in in IN cord-262892-n38r8n70 6 5 survival survival NN cord-262892-n38r8n70 6 6 rates rate NNS cord-262892-n38r8n70 6 7 is be VBZ cord-262892-n38r8n70 6 8 associated associate VBN cord-262892-n38r8n70 6 9 with with IN cord-262892-n38r8n70 6 10 enhancements enhancement NNS cord-262892-n38r8n70 6 11 in in IN cord-262892-n38r8n70 6 12 overall overall JJ cord-262892-n38r8n70 6 13 quality quality NN cord-262892-n38r8n70 6 14 of of IN cord-262892-n38r8n70 6 15 life life NN cord-262892-n38r8n70 6 16 , , , cord-262892-n38r8n70 6 17 which which WDT cord-262892-n38r8n70 6 18 reflect reflect VBP cord-262892-n38r8n70 6 19 a a DT cord-262892-n38r8n70 6 20 multidisciplinary multidisciplinary JJ cord-262892-n38r8n70 6 21 , , , cord-262892-n38r8n70 6 22 holistic holistic JJ cord-262892-n38r8n70 6 23 approach approach NN cord-262892-n38r8n70 6 24 to to TO cord-262892-n38r8n70 6 25 care care VB cord-262892-n38r8n70 6 26 . . . cord-262892-n38r8n70 7 1 Current current JJ cord-262892-n38r8n70 7 2 optimism optimism NN cord-262892-n38r8n70 7 3 starkly starkly RB cord-262892-n38r8n70 7 4 contrasts contrast VBZ cord-262892-n38r8n70 7 5 with with IN cord-262892-n38r8n70 7 6 the the DT cord-262892-n38r8n70 7 7 outlook outlook NN cord-262892-n38r8n70 7 8 and and CC cord-262892-n38r8n70 7 9 prognosis prognosis NN cord-262892-n38r8n70 7 10 two two CD cord-262892-n38r8n70 7 11 decades decade NNS cord-262892-n38r8n70 7 12 ago ago RB cord-262892-n38r8n70 7 13 , , , cord-262892-n38r8n70 7 14 when when WRB cord-262892-n38r8n70 7 15 failure failure NN cord-262892-n38r8n70 7 16 to to TO cord-262892-n38r8n70 7 17 thrive thrive VB cord-262892-n38r8n70 7 18 and and CC cord-262892-n38r8n70 7 19 wasting waste VBG cord-262892-n38r8n70 7 20 syndrome syndrome NN cord-262892-n38r8n70 7 21 from from IN cord-262892-n38r8n70 7 22 uncontrolled uncontrolled JJ cord-262892-n38r8n70 7 23 pediatric pediatric JJ cord-262892-n38r8n70 7 24 HIV HIV NNP cord-262892-n38r8n70 7 25 infection infection NN cord-262892-n38r8n70 7 26 resulted result VBD cord-262892-n38r8n70 7 27 from from IN cord-262892-n38r8n70 7 28 poor poor JJ cord-262892-n38r8n70 7 29 oral oral JJ cord-262892-n38r8n70 7 30 intake intake NN cord-262892-n38r8n70 7 31 , , , cord-262892-n38r8n70 7 32 malabsorption malabsorption NN cord-262892-n38r8n70 7 33 , , , cord-262892-n38r8n70 7 34 chronic chronic JJ cord-262892-n38r8n70 7 35 diarrhea diarrhea NN cord-262892-n38r8n70 7 36 , , , cord-262892-n38r8n70 7 37 and and CC cord-262892-n38r8n70 7 38 a a DT cord-262892-n38r8n70 7 39 persistently persistently RB cord-262892-n38r8n70 7 40 catabolic catabolic JJ cord-262892-n38r8n70 7 41 state state NN cord-262892-n38r8n70 7 42 . . . cord-262892-n38r8n70 8 1 The the DT cord-262892-n38r8n70 8 2 tenets tenet NNS cord-262892-n38r8n70 8 3 of of IN cord-262892-n38r8n70 8 4 care care NN cord-262892-n38r8n70 8 5 developed develop VBN cord-262892-n38r8n70 8 6 from from IN cord-262892-n38r8n70 8 7 that that DT cord-262892-n38r8n70 8 8 era era NN cord-262892-n38r8n70 8 9 still still RB cord-262892-n38r8n70 8 10 hold hold VBP cord-262892-n38r8n70 8 11 true true JJ cord-262892-n38r8n70 8 12 in in IN cord-262892-n38r8n70 8 13 that that IN cord-262892-n38r8n70 8 14 all all DT cord-262892-n38r8n70 8 15 infants infant NNS cord-262892-n38r8n70 8 16 , , , cord-262892-n38r8n70 8 17 children child NNS cord-262892-n38r8n70 8 18 , , , cord-262892-n38r8n70 8 19 and and CC cord-262892-n38r8n70 8 20 adolescents adolescent NNS cord-262892-n38r8n70 8 21 with with IN cord-262892-n38r8n70 8 22 HIV HIV NNP cord-262892-n38r8n70 8 23 require require VBP cord-262892-n38r8n70 8 24 comprehensive comprehensive JJ cord-262892-n38r8n70 8 25 nutritional nutritional JJ cord-262892-n38r8n70 8 26 services service NNS cord-262892-n38r8n70 8 27 in in IN cord-262892-n38r8n70 8 28 addition addition NN cord-262892-n38r8n70 8 29 to to IN cord-262892-n38r8n70 8 30 effective effective JJ cord-262892-n38r8n70 8 31 combination combination NN cord-262892-n38r8n70 8 32 antiretroviral antiretroviral JJ cord-262892-n38r8n70 8 33 therapy therapy NN cord-262892-n38r8n70 8 34 ( ( -LRB- cord-262892-n38r8n70 8 35 cART cART NNP cord-262892-n38r8n70 8 36 ) ) -RRB- cord-262892-n38r8n70 8 37 . . . cord-262892-n38r8n70 9 1 This this DT cord-262892-n38r8n70 9 2 chapter chapter NN cord-262892-n38r8n70 9 3 will will MD cord-262892-n38r8n70 9 4 review review VB cord-262892-n38r8n70 9 5 the the DT cord-262892-n38r8n70 9 6 principles principle NNS cord-262892-n38r8n70 9 7 of of IN cord-262892-n38r8n70 9 8 nutrition nutrition NN cord-262892-n38r8n70 9 9 in in IN cord-262892-n38r8n70 9 10 the the DT cord-262892-n38r8n70 9 11 pre- pre- JJ cord-262892-n38r8n70 9 12 and and CC cord-262892-n38r8n70 9 13 post post JJ cord-262892-n38r8n70 9 14 - - JJ cord-262892-n38r8n70 9 15 cART cart JJ cord-262892-n38r8n70 9 16 eras era NNS cord-262892-n38r8n70 9 17 and and CC cord-262892-n38r8n70 9 18 discuss discuss VB cord-262892-n38r8n70 9 19 the the DT cord-262892-n38r8n70 9 20 etiologic etiologic JJ cord-262892-n38r8n70 9 21 factors factor NNS cord-262892-n38r8n70 9 22 associated associate VBN cord-262892-n38r8n70 9 23 with with IN cord-262892-n38r8n70 9 24 malnutrition malnutrition NN cord-262892-n38r8n70 9 25 , , , cord-262892-n38r8n70 9 26 with with IN cord-262892-n38r8n70 9 27 an an DT cord-262892-n38r8n70 9 28 emphasis emphasis NN cord-262892-n38r8n70 9 29 on on IN cord-262892-n38r8n70 9 30 interventions intervention NNS cord-262892-n38r8n70 9 31 that that WDT cord-262892-n38r8n70 9 32 have have VBP cord-262892-n38r8n70 9 33 favorably favorably RB cord-262892-n38r8n70 9 34 impacted impact VBN cord-262892-n38r8n70 9 35 the the DT cord-262892-n38r8n70 9 36 growth growth NN cord-262892-n38r8n70 9 37 and and CC cord-262892-n38r8n70 9 38 body body NN cord-262892-n38r8n70 9 39 composition composition NN cord-262892-n38r8n70 9 40 of of IN cord-262892-n38r8n70 9 41 infants infant NNS cord-262892-n38r8n70 9 42 , , , cord-262892-n38r8n70 9 43 children child NNS cord-262892-n38r8n70 9 44 and and CC cord-262892-n38r8n70 9 45 adolescents adolescent NNS cord-262892-n38r8n70 9 46 with with IN cord-262892-n38r8n70 9 47 HIV HIV NNP cord-262892-n38r8n70 9 48 . . . cord-262892-n38r8n70 10 1 The the DT cord-262892-n38r8n70 10 2 global global JJ cord-262892-n38r8n70 10 3 pandemic pandemic NN cord-262892-n38r8n70 10 4 of of IN cord-262892-n38r8n70 10 5 human human JJ cord-262892-n38r8n70 10 6 immunodeficiency immunodeficiency NN cord-262892-n38r8n70 10 7 virus virus NN cord-262892-n38r8n70 10 8 ( ( -LRB- cord-262892-n38r8n70 10 9 HIV HIV NNP cord-262892-n38r8n70 10 10 ) ) -RRB- cord-262892-n38r8n70 10 11 infection infection NN cord-262892-n38r8n70 10 12 has have VBZ cord-262892-n38r8n70 10 13 had have VBN cord-262892-n38r8n70 10 14 grave grave JJ cord-262892-n38r8n70 10 15 consequences consequence NNS cord-262892-n38r8n70 10 16 in in IN cord-262892-n38r8n70 10 17 the the DT cord-262892-n38r8n70 10 18 lives life NNS cord-262892-n38r8n70 10 19 of of IN cord-262892-n38r8n70 10 20 affected affect VBN cord-262892-n38r8n70 10 21 infants infant NNS cord-262892-n38r8n70 10 22 , , , cord-262892-n38r8n70 10 23 children child NNS cord-262892-n38r8n70 10 24 , , , cord-262892-n38r8n70 10 25 and and CC cord-262892-n38r8n70 10 26 adolescents adolescent NNS cord-262892-n38r8n70 10 27 , , , cord-262892-n38r8n70 10 28 with with IN cord-262892-n38r8n70 10 29 more more JJR cord-262892-n38r8n70 10 30 than than IN cord-262892-n38r8n70 10 31 33 33 CD cord-262892-n38r8n70 10 32 % % NN cord-262892-n38r8n70 10 33 of of IN cord-262892-n38r8n70 10 34 infant infant NN cord-262892-n38r8n70 10 35 and and CC cord-262892-n38r8n70 10 36 child child NN cord-262892-n38r8n70 10 37 mortality mortality NN cord-262892-n38r8n70 10 38 attributed attribute VBN cord-262892-n38r8n70 10 39 to to IN cord-262892-n38r8n70 10 40 HIV HIV NNP cord-262892-n38r8n70 10 41 infection infection NN cord-262892-n38r8n70 10 42 in in IN cord-262892-n38r8n70 10 43 endemic endemic JJ cord-262892-n38r8n70 10 44 locations location NNS cord-262892-n38r8n70 10 45 [ [ -LRB- cord-262892-n38r8n70 10 46 1 1 CD cord-262892-n38r8n70 10 47 ] ] -RRB- cord-262892-n38r8n70 10 48 . . . cord-262892-n38r8n70 11 1 In in IN cord-262892-n38r8n70 11 2 settings setting NNS cord-262892-n38r8n70 11 3 where where WRB cord-262892-n38r8n70 11 4 voluntary voluntary JJ cord-262892-n38r8n70 11 5 and and CC cord-262892-n38r8n70 11 6 public public JJ cord-262892-n38r8n70 11 7 resources resource NNS cord-262892-n38r8n70 11 8 are be VBP cord-262892-n38r8n70 11 9 insufficient insufficient JJ cord-262892-n38r8n70 11 10 to to TO cord-262892-n38r8n70 11 11 provide provide VB cord-262892-n38r8n70 11 12 long long JJ cord-262892-n38r8n70 11 13 - - HYPH cord-262892-n38r8n70 11 14 term term NN cord-262892-n38r8n70 11 15 care care NN cord-262892-n38r8n70 11 16 , , , cord-262892-n38r8n70 11 17 millions million NNS cord-262892-n38r8n70 11 18 of of IN cord-262892-n38r8n70 11 19 children child NNS cord-262892-n38r8n70 11 20 initially initially RB cord-262892-n38r8n70 11 21 cared care VBD cord-262892-n38r8n70 11 22 for for IN cord-262892-n38r8n70 11 23 by by IN cord-262892-n38r8n70 11 24 relatives relative NNS cord-262892-n38r8n70 11 25 have have VBP cord-262892-n38r8n70 11 26 now now RB cord-262892-n38r8n70 11 27 been be VBN cord-262892-n38r8n70 11 28 orphaned orphan VBN cord-262892-n38r8n70 11 29 . . . cord-262892-n38r8n70 12 1 However however RB cord-262892-n38r8n70 12 2 , , , cord-262892-n38r8n70 12 3 many many JJ cord-262892-n38r8n70 12 4 guardians guardian NNS cord-262892-n38r8n70 12 5 themselves -PRON- PRP cord-262892-n38r8n70 12 6 get get VBP cord-262892-n38r8n70 12 7 sick sick JJ cord-262892-n38r8n70 12 8 or or CC cord-262892-n38r8n70 12 9 become become VBN cord-262892-n38r8n70 12 10 overwhelmed overwhelmed JJ cord-262892-n38r8n70 12 11 by by IN cord-262892-n38r8n70 12 12 the the DT cord-262892-n38r8n70 12 13 number number NN cord-262892-n38r8n70 12 14 of of IN cord-262892-n38r8n70 12 15 dependents dependent NNS cord-262892-n38r8n70 12 16 for for IN cord-262892-n38r8n70 12 17 whom whom WP cord-262892-n38r8n70 12 18 they -PRON- PRP cord-262892-n38r8n70 12 19 have have VBP cord-262892-n38r8n70 12 20 to to TO cord-262892-n38r8n70 12 21 provide provide VB cord-262892-n38r8n70 12 22 care care NN cord-262892-n38r8n70 12 23 . . . cord-262892-n38r8n70 13 1 The the DT cord-262892-n38r8n70 13 2 growing grow VBG cord-262892-n38r8n70 13 3 number number NN cord-262892-n38r8n70 13 4 of of IN cord-262892-n38r8n70 13 5 street street NN cord-262892-n38r8n70 13 6 children child NNS cord-262892-n38r8n70 13 7 and and CC cord-262892-n38r8n70 13 8 child child NN cord-262892-n38r8n70 13 9 - - HYPH cord-262892-n38r8n70 13 10 headed head VBN cord-262892-n38r8n70 13 11 households household NNS cord-262892-n38r8n70 13 12 are be VBP cord-262892-n38r8n70 13 13 often often RB cord-262892-n38r8n70 13 14 the the DT cord-262892-n38r8n70 13 15 outcomes outcome NNS cord-262892-n38r8n70 13 16 of of IN cord-262892-n38r8n70 13 17 a a DT cord-262892-n38r8n70 13 18 chain chain NN cord-262892-n38r8n70 13 19 of of IN cord-262892-n38r8n70 13 20 events event NNS cord-262892-n38r8n70 13 21 that that WDT cord-262892-n38r8n70 13 22 begin begin VBP cord-262892-n38r8n70 13 23 with with IN cord-262892-n38r8n70 13 24 the the DT cord-262892-n38r8n70 13 25 HIV HIV NNP cord-262892-n38r8n70 13 26 infection infection NN cord-262892-n38r8n70 13 27 of of IN cord-262892-n38r8n70 13 28 a a DT cord-262892-n38r8n70 13 29 mother mother NN cord-262892-n38r8n70 13 30 , , , cord-262892-n38r8n70 13 31 her -PRON- PRP$ cord-262892-n38r8n70 13 32 partner partner NN cord-262892-n38r8n70 13 33 , , , cord-262892-n38r8n70 13 34 or or CC cord-262892-n38r8n70 13 35 both both DT cord-262892-n38r8n70 13 36 . . . cord-262892-n38r8n70 14 1 In in IN cord-262892-n38r8n70 14 2 the the DT cord-262892-n38r8n70 14 3 United United NNP cord-262892-n38r8n70 14 4 States States NNP cord-262892-n38r8n70 14 5 , , , cord-262892-n38r8n70 14 6 perinatal perinatal JJ cord-262892-n38r8n70 14 7 transmission transmission NN cord-262892-n38r8n70 14 8 has have VBZ cord-262892-n38r8n70 14 9 decreased decrease VBN cord-262892-n38r8n70 14 10 to to IN cord-262892-n38r8n70 14 11 such such PDT cord-262892-n38r8n70 14 12 a a DT cord-262892-n38r8n70 14 13 significant significant JJ cord-262892-n38r8n70 14 14 extent extent NN cord-262892-n38r8n70 14 15 that that IN cord-262892-n38r8n70 14 16 current current JJ cord-262892-n38r8n70 14 17 estimates estimate NNS cord-262892-n38r8n70 14 18 indicate indicate VBP cord-262892-n38r8n70 14 19 less less JJR cord-262892-n38r8n70 14 20 than than IN cord-262892-n38r8n70 14 21 200 200 CD cord-262892-n38r8n70 14 22 infants infant NNS cord-262892-n38r8n70 14 23 born bear VBN cord-262892-n38r8n70 14 24 with with IN cord-262892-n38r8n70 14 25 HIV HIV NNP cord-262892-n38r8n70 14 26 annually annually RB cord-262892-n38r8n70 14 27 [ [ -LRB- cord-262892-n38r8n70 14 28 2 2 CD cord-262892-n38r8n70 14 29 , , , cord-262892-n38r8n70 14 30 3 3 CD cord-262892-n38r8n70 14 31 ] ] -RRB- cord-262892-n38r8n70 14 32 . . . cord-262892-n38r8n70 15 1 With with IN cord-262892-n38r8n70 15 2 the the DT cord-262892-n38r8n70 15 3 implementation implementation NN cord-262892-n38r8n70 15 4 of of IN cord-262892-n38r8n70 15 5 recommendations recommendation NNS cord-262892-n38r8n70 15 6 for for IN cord-262892-n38r8n70 15 7 universal universal JJ cord-262892-n38r8n70 15 8 prenatal prenatal JJ cord-262892-n38r8n70 15 9 HIV HIV NNP cord-262892-n38r8n70 15 10 counseling counseling NN cord-262892-n38r8n70 15 11 and and CC cord-262892-n38r8n70 15 12 testing testing NN cord-262892-n38r8n70 15 13 , , , cord-262892-n38r8n70 15 14 antiretroviral antiretroviral JJ cord-262892-n38r8n70 15 15 ( ( -LRB- cord-262892-n38r8n70 15 16 ARV ARV NNP cord-262892-n38r8n70 15 17 ) ) -RRB- cord-262892-n38r8n70 15 18 prophylaxis prophylaxis NN cord-262892-n38r8n70 15 19 , , , cord-262892-n38r8n70 15 20 scheduled schedule VBN cord-262892-n38r8n70 15 21 cesarean cesarean NN cord-262892-n38r8n70 15 22 section section NN cord-262892-n38r8n70 15 23 delivery delivery NN cord-262892-n38r8n70 15 24 , , , cord-262892-n38r8n70 15 25 and and CC cord-262892-n38r8n70 15 26 avoidance avoidance NN cord-262892-n38r8n70 15 27 of of IN cord-262892-n38r8n70 15 28 breastfeeding breastfeeding NN cord-262892-n38r8n70 15 29 , , , cord-262892-n38r8n70 15 30 the the DT cord-262892-n38r8n70 15 31 rate rate NN cord-262892-n38r8n70 15 32 of of IN cord-262892-n38r8n70 15 33 transmission transmission NN cord-262892-n38r8n70 15 34 events event NNS cord-262892-n38r8n70 15 35 has have VBZ cord-262892-n38r8n70 15 36 decreased decrease VBN cord-262892-n38r8n70 15 37 to to IN cord-262892-n38r8n70 15 38 less less JJR cord-262892-n38r8n70 15 39 than than IN cord-262892-n38r8n70 15 40 1 1 CD cord-262892-n38r8n70 15 41 % % NN cord-262892-n38r8n70 15 42 in in IN cord-262892-n38r8n70 15 43 the the DT cord-262892-n38r8n70 15 44 United United NNP cord-262892-n38r8n70 15 45 States States NNP cord-262892-n38r8n70 15 46 and and CC cord-262892-n38r8n70 15 47 Europe Europe NNP cord-262892-n38r8n70 15 48 [ [ -LRB- cord-262892-n38r8n70 15 49 4 4 CD cord-262892-n38r8n70 15 50 ] ] -RRB- cord-262892-n38r8n70 15 51 [ [ -LRB- cord-262892-n38r8n70 15 52 5 5 CD cord-262892-n38r8n70 15 53 ] ] -RRB- cord-262892-n38r8n70 15 54 [ [ -LRB- cord-262892-n38r8n70 15 55 6 6 CD cord-262892-n38r8n70 15 56 ] ] -RRB- cord-262892-n38r8n70 15 57 [ [ -LRB- cord-262892-n38r8n70 15 58 7 7 CD cord-262892-n38r8n70 15 59 ] ] -RRB- cord-262892-n38r8n70 15 60 [ [ -LRB- cord-262892-n38r8n70 15 61 8 8 CD cord-262892-n38r8n70 15 62 ] ] -RRB- cord-262892-n38r8n70 15 63 . . . cord-262892-n38r8n70 16 1 However however RB cord-262892-n38r8n70 16 2 , , , cord-262892-n38r8n70 16 3 there there EX cord-262892-n38r8n70 16 4 remains remain VBZ cord-262892-n38r8n70 16 5 an an DT cord-262892-n38r8n70 16 6 unacceptable unacceptable JJ cord-262892-n38r8n70 16 7 annual annual JJ cord-262892-n38r8n70 16 8 rate rate NN cord-262892-n38r8n70 16 9 of of IN cord-262892-n38r8n70 16 10 newly newly RB cord-262892-n38r8n70 16 11 diagnosed diagnose VBN cord-262892-n38r8n70 16 12 HIV-1 HIV-1 NNP cord-262892-n38r8n70 16 13 infections infection NNS cord-262892-n38r8n70 16 14 among among IN cord-262892-n38r8n70 16 15 infants infant NNS cord-262892-n38r8n70 16 16 in in IN cord-262892-n38r8n70 16 17 the the DT cord-262892-n38r8n70 16 18 United United NNP cord-262892-n38r8n70 16 19 States States NNP cord-262892-n38r8n70 16 20 , , , cord-262892-n38r8n70 16 21 with with IN cord-262892-n38r8n70 16 22 the the DT cord-262892-n38r8n70 16 23 persistence persistence NN cord-262892-n38r8n70 16 24 of of IN cord-262892-n38r8n70 16 25 marked marked JJ cord-262892-n38r8n70 16 26 racial racial JJ cord-262892-n38r8n70 16 27 and and CC cord-262892-n38r8n70 16 28 economic economic JJ cord-262892-n38r8n70 16 29 disparities disparity NNS cord-262892-n38r8n70 16 30 [ [ -LRB- cord-262892-n38r8n70 16 31 9 9 CD cord-262892-n38r8n70 16 32 ] ] -RRB- cord-262892-n38r8n70 16 33 . . . cord-262892-n38r8n70 17 1 Most Most JJS cord-262892-n38r8n70 17 2 pediatric pediatric JJ cord-262892-n38r8n70 17 3 HIV HIV NNP cord-262892-n38r8n70 17 4 infections infection NNS cord-262892-n38r8n70 17 5 ( ( -LRB- cord-262892-n38r8n70 17 6 > > NFP cord-262892-n38r8n70 17 7 90 90 CD cord-262892-n38r8n70 17 8 % % NN cord-262892-n38r8n70 17 9 ) ) -RRB- cord-262892-n38r8n70 17 10 are be VBP cord-262892-n38r8n70 17 11 caused cause VBN cord-262892-n38r8n70 17 12 by by IN cord-262892-n38r8n70 17 13 vertical vertical JJ cord-262892-n38r8n70 17 14 transmission transmission NN cord-262892-n38r8n70 17 15 , , , cord-262892-n38r8n70 17 16 with with IN cord-262892-n38r8n70 17 17 events event NNS cord-262892-n38r8n70 17 18 more more RBR cord-262892-n38r8n70 17 19 common common JJ cord-262892-n38r8n70 17 20 to to IN cord-262892-n38r8n70 17 21 areas area NNS cord-262892-n38r8n70 17 22 where where WRB cord-262892-n38r8n70 17 23 antenatal antenatal JJ cord-262892-n38r8n70 17 24 HIV HIV NNP cord-262892-n38r8n70 17 25 seroprevalence seroprevalence NN cord-262892-n38r8n70 17 26 is be VBZ cord-262892-n38r8n70 17 27 high high JJ cord-262892-n38r8n70 17 28 [ [ -LRB- cord-262892-n38r8n70 17 29 10 10 CD cord-262892-n38r8n70 17 30 ] ] -RRB- cord-262892-n38r8n70 17 31 ; ; : cord-262892-n38r8n70 17 32 21 21 CD cord-262892-n38r8n70 17 33 countries country NNS cord-262892-n38r8n70 17 34 in in IN cord-262892-n38r8n70 17 35 sub sub JJ cord-262892-n38r8n70 17 36 - - JJ cord-262892-n38r8n70 17 37 Saharan Saharan NNP cord-262892-n38r8n70 17 38 Africa Africa NNP cord-262892-n38r8n70 17 39 and and CC cord-262892-n38r8n70 17 40 in in IN cord-262892-n38r8n70 17 41 South South NNP cord-262892-n38r8n70 17 42 , , , cord-262892-n38r8n70 17 43 East East NNP cord-262892-n38r8n70 17 44 , , , cord-262892-n38r8n70 17 45 and and CC cord-262892-n38r8n70 17 46 Southeast Southeast NNP cord-262892-n38r8n70 17 47 Asia Asia NNP cord-262892-n38r8n70 17 48 account account VBP cord-262892-n38r8n70 17 49 for for IN cord-262892-n38r8n70 17 50 more more JJR cord-262892-n38r8n70 17 51 than than IN cord-262892-n38r8n70 17 52 90 90 CD cord-262892-n38r8n70 17 53 % % NN cord-262892-n38r8n70 17 54 of of IN cord-262892-n38r8n70 17 55 the the DT cord-262892-n38r8n70 17 56 pregnant pregnant JJ cord-262892-n38r8n70 17 57 women woman NNS cord-262892-n38r8n70 17 58 needing need VBG cord-262892-n38r8n70 17 59 ARVs arv NNS cord-262892-n38r8n70 17 60 to to TO cord-262892-n38r8n70 17 61 prevent prevent VB cord-262892-n38r8n70 17 62 vertical vertical JJ cord-262892-n38r8n70 17 63 transmission transmission NN cord-262892-n38r8n70 17 64 . . . cord-262892-n38r8n70 18 1 However however RB cord-262892-n38r8n70 18 2 , , , cord-262892-n38r8n70 18 3 global global JJ cord-262892-n38r8n70 18 4 rates rate NNS cord-262892-n38r8n70 18 5 of of IN cord-262892-n38r8n70 18 6 new new JJ cord-262892-n38r8n70 18 7 HIV HIV NNP cord-262892-n38r8n70 18 8 infections infection NNS cord-262892-n38r8n70 18 9 and and CC cord-262892-n38r8n70 18 10 prevalence prevalence NN cord-262892-n38r8n70 18 11 among among IN cord-262892-n38r8n70 18 12 young young JJ cord-262892-n38r8n70 18 13 people people NNS cord-262892-n38r8n70 18 14 have have VBP cord-262892-n38r8n70 18 15 fallen fall VBN cord-262892-n38r8n70 18 16 in in IN cord-262892-n38r8n70 18 17 many many JJ cord-262892-n38r8n70 18 18 countries country NNS cord-262892-n38r8n70 18 19 , , , cord-262892-n38r8n70 18 20 likely likely RB cord-262892-n38r8n70 18 21 due due IN cord-262892-n38r8n70 18 22 to to IN cord-262892-n38r8n70 18 23 reductions reduction NNS cord-262892-n38r8n70 18 24 in in IN cord-262892-n38r8n70 18 25 vertical vertical JJ cord-262892-n38r8n70 18 26 transmission transmission NN cord-262892-n38r8n70 18 27 rates rate NNS cord-262892-n38r8n70 18 28 and and CC cord-262892-n38r8n70 18 29 improvement improvement NN cord-262892-n38r8n70 18 30 in in IN cord-262892-n38r8n70 18 31 access access NN cord-262892-n38r8n70 18 32 to to IN cord-262892-n38r8n70 18 33 effective effective JJ cord-262892-n38r8n70 18 34 cART cART NNP cord-262892-n38r8n70 18 35 , , , cord-262892-n38r8n70 18 36 which which WDT cord-262892-n38r8n70 18 37 has have VBZ cord-262892-n38r8n70 18 38 decreased decrease VBN cord-262892-n38r8n70 18 39 secondary secondary JJ cord-262892-n38r8n70 18 40 transmission transmission NN cord-262892-n38r8n70 18 41 events event NNS cord-262892-n38r8n70 18 42 . . . cord-262892-n38r8n70 19 1 A a DT cord-262892-n38r8n70 19 2 CLINICAL clinical JJ cord-262892-n38r8n70 19 3 OVERVIEW overview NN cord-262892-n38r8n70 19 4 Perinatal perinatal JJ cord-262892-n38r8n70 19 5 infection infection NN cord-262892-n38r8n70 19 6 occurs occur VBZ cord-262892-n38r8n70 19 7 at at IN cord-262892-n38r8n70 19 8 a a DT cord-262892-n38r8n70 19 9 time time NN cord-262892-n38r8n70 19 10 of of IN cord-262892-n38r8n70 19 11 relative relative JJ cord-262892-n38r8n70 19 12 immunologic immunologic JJ cord-262892-n38r8n70 19 13 immaturity immaturity NN cord-262892-n38r8n70 19 14 . . . cord-262892-n38r8n70 20 1 The the DT cord-262892-n38r8n70 20 2 inability inability NN cord-262892-n38r8n70 20 3 to to TO cord-262892-n38r8n70 20 4 control control VB cord-262892-n38r8n70 20 5 viremia viremia NN cord-262892-n38r8n70 20 6 exposes expose VBZ cord-262892-n38r8n70 20 7 the the DT cord-262892-n38r8n70 20 8 thymus thymus NN cord-262892-n38r8n70 20 9 and and CC cord-262892-n38r8n70 20 10 other other JJ cord-262892-n38r8n70 20 11 lymphoid lymphoid JJ cord-262892-n38r8n70 20 12 tissue tissue NN cord-262892-n38r8n70 20 13 to to IN cord-262892-n38r8n70 20 14 HIV-1-mediated hiv-1-mediated JJ cord-262892-n38r8n70 20 15 destruction destruction NN cord-262892-n38r8n70 20 16 at at IN cord-262892-n38r8n70 20 17 a a DT cord-262892-n38r8n70 20 18 time time NN cord-262892-n38r8n70 20 19 of of IN cord-262892-n38r8n70 20 20 active active JJ cord-262892-n38r8n70 20 21 thymopoiesis thymopoiesis NNP cord-262892-n38r8n70 20 22 and and CC cord-262892-n38r8n70 20 23 lymphopoiesis lymphopoiesis NNP cord-262892-n38r8n70 20 24 [ [ -LRB- cord-262892-n38r8n70 20 25 11 11 CD cord-262892-n38r8n70 20 26 ] ] -RRB- cord-262892-n38r8n70 20 27 . . . cord-262892-n38r8n70 21 1 Given give VBN cord-262892-n38r8n70 21 2 that that IN cord-262892-n38r8n70 21 3 the the DT cord-262892-n38r8n70 21 4 virus virus NN cord-262892-n38r8n70 21 5 is be VBZ cord-262892-n38r8n70 21 6 transmitted transmit VBN cord-262892-n38r8n70 21 7 from from IN cord-262892-n38r8n70 21 8 the the DT cord-262892-n38r8n70 21 9 mother mother NN cord-262892-n38r8n70 21 10 and and CC cord-262892-n38r8n70 21 11 that that IN cord-262892-n38r8n70 21 12 the the DT cord-262892-n38r8n70 21 13 degree degree NN cord-262892-n38r8n70 21 14 of of IN cord-262892-n38r8n70 21 15 human human JJ cord-262892-n38r8n70 21 16 leukocyte leukocyte NN cord-262892-n38r8n70 21 17 antigen antigen NN cord-262892-n38r8n70 21 18 class class NN cord-262892-n38r8n70 21 19 I -PRON- PRP cord-262892-n38r8n70 21 20 sharing share VBG cord-262892-n38r8n70 21 21 between between IN cord-262892-n38r8n70 21 22 mother mother NN cord-262892-n38r8n70 21 23 and and CC cord-262892-n38r8n70 21 24 infant infant NN cord-262892-n38r8n70 21 25 is be VBZ cord-262892-n38r8n70 21 26 high high JJ cord-262892-n38r8n70 21 27 , , , cord-262892-n38r8n70 21 28 the the DT cord-262892-n38r8n70 21 29 virus virus NN cord-262892-n38r8n70 21 30 could could MD cord-262892-n38r8n70 21 31 evade evade VB cord-262892-n38r8n70 21 32 the the DT cord-262892-n38r8n70 21 33 protective protective JJ cord-262892-n38r8n70 21 34 immune immune JJ cord-262892-n38r8n70 21 35 response response NN cord-262892-n38r8n70 21 36 of of IN cord-262892-n38r8n70 21 37 the the DT cord-262892-n38r8n70 21 38 newborn newborn NN cord-262892-n38r8n70 21 39 , , , cord-262892-n38r8n70 21 40 which which WDT cord-262892-n38r8n70 21 41 results result VBZ cord-262892-n38r8n70 21 42 in in IN cord-262892-n38r8n70 21 43 accelerated accelerated JJ cord-262892-n38r8n70 21 44 disease disease NN cord-262892-n38r8n70 21 45 progression progression NN cord-262892-n38r8n70 21 46 [ [ -LRB- cord-262892-n38r8n70 21 47 12 12 CD cord-262892-n38r8n70 21 48 ] ] -RRB- cord-262892-n38r8n70 21 49 . . . cord-262892-n38r8n70 22 1 In in IN cord-262892-n38r8n70 22 2 contrast contrast NN cord-262892-n38r8n70 22 3 to to IN cord-262892-n38r8n70 22 4 adults adult NNS cord-262892-n38r8n70 22 5 , , , cord-262892-n38r8n70 22 6 HIV-1-related hiv-1-relate VBN cord-262892-n38r8n70 22 7 symptoms symptom NNS cord-262892-n38r8n70 22 8 , , , cord-262892-n38r8n70 22 9 CD4 CD4 NNP cord-262892-n38r8n70 22 10 + + CC cord-262892-n38r8n70 22 11 T t NN cord-262892-n38r8n70 22 12 cell cell NN cord-262892-n38r8n70 22 13 depletion depletion NN cord-262892-n38r8n70 22 14 , , , cord-262892-n38r8n70 22 15 or or CC cord-262892-n38r8n70 22 16 both both DT cord-262892-n38r8n70 22 17 develop develop VBP cord-262892-n38r8n70 22 18 in in IN cord-262892-n38r8n70 22 19 most most RBS cord-262892-n38r8n70 22 20 untreated untreated JJ cord-262892-n38r8n70 22 21 vertically vertically RB cord-262892-n38r8n70 22 22 infected infect VBN cord-262892-n38r8n70 22 23 children child NNS cord-262892-n38r8n70 22 24 within within IN cord-262892-n38r8n70 22 25 the the DT cord-262892-n38r8n70 22 26 first first JJ cord-262892-n38r8n70 22 27 few few JJ cord-262892-n38r8n70 22 28 years year NNS cord-262892-n38r8n70 22 29 of of IN cord-262892-n38r8n70 22 30 life life NN cord-262892-n38r8n70 22 31 [ [ -LRB- cord-262892-n38r8n70 22 32 13 13 CD cord-262892-n38r8n70 22 33 ] ] -RRB- cord-262892-n38r8n70 22 34 . . . cord-262892-n38r8n70 23 1 In in IN cord-262892-n38r8n70 23 2 addition addition NN cord-262892-n38r8n70 23 3 , , , cord-262892-n38r8n70 23 4 plasma plasma NN cord-262892-n38r8n70 23 5 HIV-1 HIV-1 NNP cord-262892-n38r8n70 23 6 ribonucleic ribonucleic NN cord-262892-n38r8n70 23 7 acid acid NN cord-262892-n38r8n70 23 8 ( ( -LRB- cord-262892-n38r8n70 23 9 RNA RNA NNP cord-262892-n38r8n70 23 10 ) ) -RRB- cord-262892-n38r8n70 23 11 levels level NNS cord-262892-n38r8n70 23 12 remained remain VBD cord-262892-n38r8n70 23 13 elevated elevated JJ cord-262892-n38r8n70 23 14 over over IN cord-262892-n38r8n70 23 15 the the DT cord-262892-n38r8n70 23 16 first first JJ cord-262892-n38r8n70 23 17 2 2 CD cord-262892-n38r8n70 23 18 years year NNS cord-262892-n38r8n70 23 19 among among IN cord-262892-n38r8n70 23 20 infants infant NNS cord-262892-n38r8n70 23 21 [ [ -LRB- cord-262892-n38r8n70 23 22 14 14 CD cord-262892-n38r8n70 23 23 ] ] -RRB- cord-262892-n38r8n70 23 24 and and CC cord-262892-n38r8n70 23 25 do do VBP cord-262892-n38r8n70 23 26 not not RB cord-262892-n38r8n70 23 27 decrease decrease VB cord-262892-n38r8n70 23 28 to to IN cord-262892-n38r8n70 23 29 less less JJR cord-262892-n38r8n70 23 30 than than IN cord-262892-n38r8n70 23 31 10 10 CD cord-262892-n38r8n70 23 32 5 5 CD cord-262892-n38r8n70 23 33 copies copy NNS cord-262892-n38r8n70 23 34 / / SYM cord-262892-n38r8n70 23 35 mL ml XX cord-262892-n38r8n70 23 36 through through RP cord-262892-n38r8n70 23 37 at at IN cord-262892-n38r8n70 23 38 least least JJS cord-262892-n38r8n70 23 39 the the DT cord-262892-n38r8n70 23 40 third third JJ cord-262892-n38r8n70 23 41 year year NN cord-262892-n38r8n70 23 42 of of IN cord-262892-n38r8n70 23 43 life life NN cord-262892-n38r8n70 23 44 [ [ -LRB- cord-262892-n38r8n70 23 45 15 15 CD cord-262892-n38r8n70 23 46 ] ] -RRB- cord-262892-n38r8n70 23 47 . . . cord-262892-n38r8n70 24 1 The the DT cord-262892-n38r8n70 24 2 prolonged prolonged JJ cord-262892-n38r8n70 24 3 elevation elevation NN cord-262892-n38r8n70 24 4 of of IN cord-262892-n38r8n70 24 5 plasma plasma NN cord-262892-n38r8n70 24 6 HIV-1 HIV-1 NNP cord-262892-n38r8n70 24 7 RNA RNA NNP cord-262892-n38r8n70 24 8 levels level NNS cord-262892-n38r8n70 24 9 may may MD cord-262892-n38r8n70 24 10 be be VB cord-262892-n38r8n70 24 11 related relate VBN cord-262892-n38r8n70 24 12 to to IN cord-262892-n38r8n70 24 13 the the DT cord-262892-n38r8n70 24 14 kinetics kinetic NNS cord-262892-n38r8n70 24 15 of of IN cord-262892-n38r8n70 24 16 viral viral JJ cord-262892-n38r8n70 24 17 replication replication NN cord-262892-n38r8n70 24 18 , , , cord-262892-n38r8n70 24 19 the the DT cord-262892-n38r8n70 24 20 size size NN cord-262892-n38r8n70 24 21 of of IN cord-262892-n38r8n70 24 22 the the DT cord-262892-n38r8n70 24 23 pool pool NN cord-262892-n38r8n70 24 24 of of IN cord-262892-n38r8n70 24 25 host host NN cord-262892-n38r8n70 24 26 cells cell NNS cord-262892-n38r8n70 24 27 that that WDT cord-262892-n38r8n70 24 28 are be VBP cord-262892-n38r8n70 24 29 permissive permissive JJ cord-262892-n38r8n70 24 30 to to IN cord-262892-n38r8n70 24 31 viral viral JJ cord-262892-n38r8n70 24 32 replication replication NN cord-262892-n38r8n70 24 33 , , , cord-262892-n38r8n70 24 34 and and CC cord-262892-n38r8n70 24 35 immature immature JJ cord-262892-n38r8n70 24 36 virus virus NN cord-262892-n38r8n70 24 37 - - HYPH cord-262892-n38r8n70 24 38 specific specific JJ cord-262892-n38r8n70 24 39 immune immune JJ cord-262892-n38r8n70 24 40 responses response NNS cord-262892-n38r8n70 24 41 . . . cord-262892-n38r8n70 25 1 II II NNP cord-262892-n38r8n70 25 2 . . . cord-262892-n38r8n70 26 1 NUTRITION NUTRITION NNP cord-262892-n38r8n70 26 2 AND and CC cord-262892-n38r8n70 26 3 LIFESTYLE lifestyle NN cord-262892-n38r8n70 27 1 The the DT cord-262892-n38r8n70 27 2 infection infection NN cord-262892-n38r8n70 27 3 in in IN cord-262892-n38r8n70 27 4 perinatally perinatally RB cord-262892-n38r8n70 27 5 infected infect VBN cord-262892-n38r8n70 27 6 infants infant NNS cord-262892-n38r8n70 27 7 and and CC cord-262892-n38r8n70 27 8 children child NNS cord-262892-n38r8n70 27 9 progresses progress VBZ cord-262892-n38r8n70 27 10 more more RBR cord-262892-n38r8n70 27 11 rapidly rapidly RB cord-262892-n38r8n70 27 12 than than IN cord-262892-n38r8n70 27 13 in in IN cord-262892-n38r8n70 27 14 adults adult NNS cord-262892-n38r8n70 27 15 . . . cord-262892-n38r8n70 28 1 Although although IN cord-262892-n38r8n70 28 2 4 4 CD cord-262892-n38r8n70 28 3 % % NN cord-262892-n38r8n70 28 4 of of IN cord-262892-n38r8n70 28 5 the the DT cord-262892-n38r8n70 28 6 world world NN cord-262892-n38r8n70 28 7 's 's POS cord-262892-n38r8n70 28 8 population population NN cord-262892-n38r8n70 28 9 with with IN cord-262892-n38r8n70 28 10 HIV-1 HIV-1 NNP cord-262892-n38r8n70 28 11 infection infection NN cord-262892-n38r8n70 28 12 comprises comprise VBZ cord-262892-n38r8n70 28 13 children child NNS cord-262892-n38r8n70 28 14 , , , cord-262892-n38r8n70 28 15 20 20 CD cord-262892-n38r8n70 28 16 % % NN cord-262892-n38r8n70 28 17 of of IN cord-262892-n38r8n70 28 18 all all DT cord-262892-n38r8n70 28 19 AIDS AIDS NNP cord-262892-n38r8n70 28 20 deaths death NNS cord-262892-n38r8n70 28 21 were be VBD cord-262892-n38r8n70 28 22 previously previously RB cord-262892-n38r8n70 28 23 in in IN cord-262892-n38r8n70 28 24 this this DT cord-262892-n38r8n70 28 25 group group NN cord-262892-n38r8n70 28 26 . . . cord-262892-n38r8n70 29 1 Early early JJ cord-262892-n38r8n70 29 2 studies study NNS cord-262892-n38r8n70 29 3 before before IN cord-262892-n38r8n70 29 4 the the DT cord-262892-n38r8n70 29 5 era era NN cord-262892-n38r8n70 29 6 of of IN cord-262892-n38r8n70 29 7 cART cART NNP cord-262892-n38r8n70 29 8 indicated indicate VBD cord-262892-n38r8n70 29 9 that that IN cord-262892-n38r8n70 29 10 a a DT cord-262892-n38r8n70 29 11 subset subset NN cord-262892-n38r8n70 29 12 of of IN cord-262892-n38r8n70 29 13 children child NNS cord-262892-n38r8n70 29 14 ( ( -LRB- cord-262892-n38r8n70 29 15 ~25 ~25 CD cord-262892-n38r8n70 29 16 % % NN cord-262892-n38r8n70 29 17 ) ) -RRB- cord-262892-n38r8n70 29 18 progressed progress VBD cord-262892-n38r8n70 29 19 very very RB cord-262892-n38r8n70 29 20 rapidly rapidly RB cord-262892-n38r8n70 29 21 to to IN cord-262892-n38r8n70 29 22 AIDS AIDS NNP cord-262892-n38r8n70 29 23 within within IN cord-262892-n38r8n70 29 24 1 1 CD cord-262892-n38r8n70 29 25 year year NN cord-262892-n38r8n70 29 26 . . . cord-262892-n38r8n70 30 1 The the DT cord-262892-n38r8n70 30 2 median median JJ cord-262892-n38r8n70 30 3 time time NN cord-262892-n38r8n70 30 4 to to IN cord-262892-n38r8n70 30 5 AIDS AIDS NNP cord-262892-n38r8n70 30 6 for for IN cord-262892-n38r8n70 30 7 the the DT cord-262892-n38r8n70 30 8 remaining remain VBG cord-262892-n38r8n70 30 9 75 75 CD cord-262892-n38r8n70 30 10 % % NN cord-262892-n38r8n70 30 11 was be VBD cord-262892-n38r8n70 30 12 7 7 CD cord-262892-n38r8n70 30 13 years year NNS cord-262892-n38r8n70 30 14 [ [ -LRB- cord-262892-n38r8n70 30 15 13 13 CD cord-262892-n38r8n70 30 16 ] ] -RRB- cord-262892-n38r8n70 30 17 . . . cord-262892-n38r8n70 31 1 In in IN cord-262892-n38r8n70 31 2 adults adult NNS cord-262892-n38r8n70 31 3 , , , cord-262892-n38r8n70 31 4 opportunistic opportunistic JJ cord-262892-n38r8n70 31 5 infections infection NNS cord-262892-n38r8n70 31 6 ( ( -LRB- cord-262892-n38r8n70 31 7 OIs OIs NNP cord-262892-n38r8n70 31 8 ) ) -RRB- cord-262892-n38r8n70 31 9 are be VBP cord-262892-n38r8n70 31 10 often often RB cord-262892-n38r8n70 31 11 secondary secondary JJ cord-262892-n38r8n70 31 12 to to IN cord-262892-n38r8n70 31 13 the the DT cord-262892-n38r8n70 31 14 reactivation reactivation NN cord-262892-n38r8n70 31 15 of of IN cord-262892-n38r8n70 31 16 pathogens pathogen NNS cord-262892-n38r8n70 31 17 acquired acquire VBN cord-262892-n38r8n70 31 18 before before IN cord-262892-n38r8n70 31 19 HIV HIV NNP cord-262892-n38r8n70 31 20 infection infection NN cord-262892-n38r8n70 31 21 . . . cord-262892-n38r8n70 32 1 In in IN cord-262892-n38r8n70 32 2 contrast contrast NN cord-262892-n38r8n70 32 3 , , , cord-262892-n38r8n70 32 4 in in IN cord-262892-n38r8n70 32 5 infants infant NNS cord-262892-n38r8n70 32 6 and and CC cord-262892-n38r8n70 32 7 children child NNS cord-262892-n38r8n70 32 8 with with IN cord-262892-n38r8n70 32 9 vertical vertical JJ cord-262892-n38r8n70 32 10 infection infection NN cord-262892-n38r8n70 32 11 , , , cord-262892-n38r8n70 32 12 OIs OIs NNP cord-262892-n38r8n70 32 13 often often RB cord-262892-n38r8n70 32 14 reflect reflect VBP cord-262892-n38r8n70 32 15 primary primary JJ cord-262892-n38r8n70 32 16 acquisition acquisition NN cord-262892-n38r8n70 32 17 of of IN cord-262892-n38r8n70 32 18 host host NN cord-262892-n38r8n70 32 19 pathogens pathogen NNS cord-262892-n38r8n70 32 20 during during IN cord-262892-n38r8n70 32 21 ongoing ongoing JJ cord-262892-n38r8n70 32 22 HIV HIV NNP cord-262892-n38r8n70 32 23 replication replication NN cord-262892-n38r8n70 32 24 and and CC cord-262892-n38r8n70 32 25 advancing advance VBG cord-262892-n38r8n70 32 26 immunosuppression immunosuppression NN cord-262892-n38r8n70 32 27 . . . cord-262892-n38r8n70 33 1 For for IN cord-262892-n38r8n70 33 2 example example NN cord-262892-n38r8n70 33 3 , , , cord-262892-n38r8n70 33 4 young young JJ cord-262892-n38r8n70 33 5 children child NNS cord-262892-n38r8n70 33 6 with with IN cord-262892-n38r8n70 33 7 active active JJ cord-262892-n38r8n70 33 8 tuberculosis tuberculosis NN cord-262892-n38r8n70 33 9 more more RBR cord-262892-n38r8n70 33 10 often often RB cord-262892-n38r8n70 33 11 present present JJ cord-262892-n38r8n70 33 12 with with IN cord-262892-n38r8n70 33 13 miliary miliary JJ cord-262892-n38r8n70 33 14 disease disease NN cord-262892-n38r8n70 33 15 . . . cord-262892-n38r8n70 34 1 Without without IN cord-262892-n38r8n70 34 2 effective effective JJ cord-262892-n38r8n70 34 3 cART cART NNP cord-262892-n38r8n70 34 4 , , , cord-262892-n38r8n70 34 5 the the DT cord-262892-n38r8n70 34 6 most most RBS cord-262892-n38r8n70 34 7 common common JJ cord-262892-n38r8n70 34 8 OIs ois NN cord-262892-n38r8n70 34 9 in in IN cord-262892-n38r8n70 34 10 children child NNS cord-262892-n38r8n70 34 11 include include VBP cord-262892-n38r8n70 34 12 serious serious JJ cord-262892-n38r8n70 34 13 bacterial bacterial JJ cord-262892-n38r8n70 34 14 infections infection NNS cord-262892-n38r8n70 34 15 such such JJ cord-262892-n38r8n70 34 16 as as IN cord-262892-n38r8n70 34 17 pneumonia pneumonia NN cord-262892-n38r8n70 34 18 and and CC cord-262892-n38r8n70 34 19 bacteremia bacteremia NN cord-262892-n38r8n70 34 20 . . . cord-262892-n38r8n70 35 1 Common common JJ cord-262892-n38r8n70 35 2 copathogens copathogen NNS cord-262892-n38r8n70 35 3 and and CC cord-262892-n38r8n70 35 4 OIs OIs NNP cord-262892-n38r8n70 35 5 that that WDT cord-262892-n38r8n70 35 6 are be VBP cord-262892-n38r8n70 35 7 difficult difficult JJ cord-262892-n38r8n70 35 8 to to TO cord-262892-n38r8n70 35 9 eradicate eradicate VB cord-262892-n38r8n70 35 10 without without IN cord-262892-n38r8n70 35 11 successful successful JJ cord-262892-n38r8n70 35 12 immune immune JJ cord-262892-n38r8n70 35 13 reconstitution reconstitution NN cord-262892-n38r8n70 35 14 include include VBP cord-262892-n38r8n70 35 15 chronic chronic JJ cord-262892-n38r8n70 35 16 mucosal mucosal NN cord-262892-n38r8n70 35 17 or or CC cord-262892-n38r8n70 35 18 disseminated disseminate VBN cord-262892-n38r8n70 35 19 infections infection NNS cord-262892-n38r8n70 35 20 with with IN cord-262892-n38r8n70 35 21 herpesviruses herpesviruse NNS cord-262892-n38r8n70 35 22 , , , cord-262892-n38r8n70 35 23 namely namely RB cord-262892-n38r8n70 35 24 , , , cord-262892-n38r8n70 35 25 cytomegalovirus cytomegalovirus NNP cord-262892-n38r8n70 35 26 ( ( -LRB- cord-262892-n38r8n70 35 27 CMV CMV NNP cord-262892-n38r8n70 35 28 ) ) -RRB- cord-262892-n38r8n70 35 29 , , , cord-262892-n38r8n70 35 30 herpes herpes NN cord-262892-n38r8n70 35 31 simplex simplex NNP cord-262892-n38r8n70 35 32 virus virus NN cord-262892-n38r8n70 35 33 ( ( -LRB- cord-262892-n38r8n70 35 34 HSV HSV NNP cord-262892-n38r8n70 35 35 ) ) -RRB- cord-262892-n38r8n70 35 36 , , , cord-262892-n38r8n70 35 37 human human JJ cord-262892-n38r8n70 35 38 herpes herpes NN cord-262892-n38r8n70 35 39 virus virus NN cord-262892-n38r8n70 35 40 8 8 CD cord-262892-n38r8n70 35 41 ( ( -LRB- cord-262892-n38r8n70 35 42 HHV8 HHV8 NNP cord-262892-n38r8n70 35 43 ) ) -RRB- cord-262892-n38r8n70 35 44 and and CC cord-262892-n38r8n70 35 45 varicella varicella NN cord-262892-n38r8n70 35 46 zoster zoster NNP cord-262892-n38r8n70 35 47 virus virus NN cord-262892-n38r8n70 35 48 ( ( -LRB- cord-262892-n38r8n70 35 49 VZV VZV NNP cord-262892-n38r8n70 35 50 ) ) -RRB- cord-262892-n38r8n70 35 51 . . . cord-262892-n38r8n70 36 1 Primary primary JJ cord-262892-n38r8n70 36 2 disseminated disseminate VBN cord-262892-n38r8n70 36 3 and and CC cord-262892-n38r8n70 36 4 reactivated reactivate VBN cord-262892-n38r8n70 36 5 tuberculosis tuberculosis NN cord-262892-n38r8n70 36 6 is be VBZ cord-262892-n38r8n70 36 7 a a DT cord-262892-n38r8n70 36 8 major major JJ cord-262892-n38r8n70 36 9 cause cause NN cord-262892-n38r8n70 36 10 of of IN cord-262892-n38r8n70 36 11 morbidity morbidity NN cord-262892-n38r8n70 36 12 and and CC cord-262892-n38r8n70 36 13 mortality mortality NN cord-262892-n38r8n70 36 14 among among IN cord-262892-n38r8n70 36 15 children child NNS cord-262892-n38r8n70 36 16 with with IN cord-262892-n38r8n70 36 17 HIV HIV NNP cord-262892-n38r8n70 36 18 in in IN cord-262892-n38r8n70 36 19 communities community NNS cord-262892-n38r8n70 36 20 where where WRB cord-262892-n38r8n70 36 21 infection infection NN cord-262892-n38r8n70 36 22 with with IN cord-262892-n38r8n70 36 23 the the DT cord-262892-n38r8n70 36 24 pathogen pathogen NN cord-262892-n38r8n70 36 25 is be VBZ cord-262892-n38r8n70 36 26 endemic endemic JJ cord-262892-n38r8n70 36 27 . . . cord-262892-n38r8n70 37 1 Disseminated disseminate VBN cord-262892-n38r8n70 37 2 disease disease NN cord-262892-n38r8n70 37 3 with with IN cord-262892-n38r8n70 37 4 Mycobacterium Mycobacterium NNP cord-262892-n38r8n70 37 5 avium avium NN cord-262892-n38r8n70 37 6 complex complex NN cord-262892-n38r8n70 37 7 may may MD cord-262892-n38r8n70 37 8 occur occur VB cord-262892-n38r8n70 37 9 in in IN cord-262892-n38r8n70 37 10 children child NNS cord-262892-n38r8n70 37 11 with with IN cord-262892-n38r8n70 37 12 HIV HIV NNP cord-262892-n38r8n70 37 13 and and CC cord-262892-n38r8n70 37 14 advanced advanced JJ cord-262892-n38r8n70 37 15 immunologic immunologic JJ cord-262892-n38r8n70 37 16 deterioration deterioration NN cord-262892-n38r8n70 37 17 . . . cord-262892-n38r8n70 38 1 Pneumocystis Pneumocystis NNP cord-262892-n38r8n70 38 2 jiroveci jiroveci NNP cord-262892-n38r8n70 38 3 ( ( -LRB- cord-262892-n38r8n70 38 4 formerly formerly RB cord-262892-n38r8n70 38 5 carinii carinii FW cord-262892-n38r8n70 38 6 ) ) -RRB- cord-262892-n38r8n70 38 7 pneumonia pneumonia NN cord-262892-n38r8n70 38 8 ( ( -LRB- cord-262892-n38r8n70 38 9 PCP PCP NNP cord-262892-n38r8n70 38 10 ) ) -RRB- cord-262892-n38r8n70 38 11 is be VBZ cord-262892-n38r8n70 38 12 a a DT cord-262892-n38r8n70 38 13 common common JJ cord-262892-n38r8n70 38 14 and and CC cord-262892-n38r8n70 38 15 serious serious JJ cord-262892-n38r8n70 38 16 OI oi NN cord-262892-n38r8n70 38 17 associated associate VBN cord-262892-n38r8n70 38 18 with with IN cord-262892-n38r8n70 38 19 a a DT cord-262892-n38r8n70 38 20 high high JJ cord-262892-n38r8n70 38 21 mortality mortality NN cord-262892-n38r8n70 38 22 rate rate NN cord-262892-n38r8n70 38 23 . . . cord-262892-n38r8n70 39 1 Pneumonia pneumonia NN cord-262892-n38r8n70 39 2 most most RBS cord-262892-n38r8n70 39 3 often often RB cord-262892-n38r8n70 39 4 manifests manifest VBZ cord-262892-n38r8n70 39 5 between between IN cord-262892-n38r8n70 39 6 3 3 CD cord-262892-n38r8n70 39 7 and and CC cord-262892-n38r8n70 39 8 6 6 CD cord-262892-n38r8n70 39 9 months month NNS cord-262892-n38r8n70 39 10 of of IN cord-262892-n38r8n70 39 11 age age NN cord-262892-n38r8n70 39 12 in in IN cord-262892-n38r8n70 39 13 infants infant NNS cord-262892-n38r8n70 39 14 with with IN cord-262892-n38r8n70 39 15 vertically vertically RB cord-262892-n38r8n70 39 16 acquired acquire VBN cord-262892-n38r8n70 39 17 HIV HIV NNP cord-262892-n38r8n70 39 18 infection infection NN cord-262892-n38r8n70 39 19 . . . cord-262892-n38r8n70 40 1 Candidiasis candidiasis NN cord-262892-n38r8n70 40 2 ( ( -LRB- cord-262892-n38r8n70 40 3 topical topical JJ cord-262892-n38r8n70 40 4 , , , cord-262892-n38r8n70 40 5 oral oral JJ cord-262892-n38r8n70 40 6 , , , cord-262892-n38r8n70 40 7 esophageal esophageal JJ cord-262892-n38r8n70 40 8 , , , cord-262892-n38r8n70 40 9 and and CC cord-262892-n38r8n70 40 10 tracheobronchial tracheobronchial NN cord-262892-n38r8n70 40 11 ) ) -RRB- cord-262892-n38r8n70 40 12 is be VBZ cord-262892-n38r8n70 40 13 the the DT cord-262892-n38r8n70 40 14 most most RBS cord-262892-n38r8n70 40 15 common common JJ cord-262892-n38r8n70 40 16 fungal fungal JJ cord-262892-n38r8n70 40 17 infection infection NN cord-262892-n38r8n70 40 18 in in IN cord-262892-n38r8n70 40 19 these these DT cord-262892-n38r8n70 40 20 children child NNS cord-262892-n38r8n70 40 21 . . . cord-262892-n38r8n70 41 1 Causes cause NNS cord-262892-n38r8n70 41 2 of of IN cord-262892-n38r8n70 41 3 acute acute JJ cord-262892-n38r8n70 41 4 and and CC cord-262892-n38r8n70 41 5 chronic chronic JJ cord-262892-n38r8n70 41 6 central central JJ cord-262892-n38r8n70 41 7 nervous nervous JJ cord-262892-n38r8n70 41 8 system system NN cord-262892-n38r8n70 41 9 ( ( -LRB- cord-262892-n38r8n70 41 10 CNS CNS NNP cord-262892-n38r8n70 41 11 ) ) -RRB- cord-262892-n38r8n70 41 12 infections infection NNS cord-262892-n38r8n70 41 13 include include VBP cord-262892-n38r8n70 41 14 those those DT cord-262892-n38r8n70 41 15 caused cause VBN cord-262892-n38r8n70 41 16 by by IN cord-262892-n38r8n70 41 17 Cryptococcus Cryptococcus NNP cord-262892-n38r8n70 41 18 neoformans neoforman NNS cord-262892-n38r8n70 41 19 , , , cord-262892-n38r8n70 41 20 and and CC cord-262892-n38r8n70 41 21 Toxoplasma toxoplasma NN cord-262892-n38r8n70 41 22 gondii gondii NN cord-262892-n38r8n70 41 23 . . . cord-262892-n38r8n70 42 1 Less less RBR cord-262892-n38r8n70 42 2 commonly commonly RB cord-262892-n38r8n70 42 3 observed observe VBN cord-262892-n38r8n70 42 4 OIs OIs NNP cord-262892-n38r8n70 42 5 include include VBP cord-262892-n38r8n70 42 6 cryptosporidiosis cryptosporidiosis NN cord-262892-n38r8n70 42 7 and and CC cord-262892-n38r8n70 42 8 systemic systemic JJ cord-262892-n38r8n70 42 9 fungal fungal JJ cord-262892-n38r8n70 42 10 infections infection NNS cord-262892-n38r8n70 42 11 . . . cord-262892-n38r8n70 43 1 Clinical clinical JJ cord-262892-n38r8n70 43 2 presentations presentation NNS cord-262892-n38r8n70 43 3 include include VBP cord-262892-n38r8n70 43 4 hepatosplenomegaly hepatosplenomegaly NNP cord-262892-n38r8n70 43 5 , , , cord-262892-n38r8n70 43 6 failure failure NN cord-262892-n38r8n70 43 7 to to TO cord-262892-n38r8n70 43 8 thrive thrive VB cord-262892-n38r8n70 43 9 , , , cord-262892-n38r8n70 43 10 oral oral JJ cord-262892-n38r8n70 43 11 candidiasis candidiasis NN cord-262892-n38r8n70 43 12 , , , cord-262892-n38r8n70 43 13 recurrent recurrent JJ cord-262892-n38r8n70 43 14 diarrhea diarrhea NN cord-262892-n38r8n70 43 15 , , , cord-262892-n38r8n70 43 16 parotitis parotitis NNP cord-262892-n38r8n70 43 17 , , , cord-262892-n38r8n70 43 18 cardiomyopathy cardiomyopathy NN cord-262892-n38r8n70 43 19 , , , cord-262892-n38r8n70 43 20 hepatitis hepatitis NN cord-262892-n38r8n70 43 21 , , , cord-262892-n38r8n70 43 22 nephropathy nephropathy NN cord-262892-n38r8n70 43 23 , , , cord-262892-n38r8n70 43 24 developmental developmental JJ cord-262892-n38r8n70 43 25 delay delay NN cord-262892-n38r8n70 43 26 , , , cord-262892-n38r8n70 43 27 encephalopathy encephalopathy NN cord-262892-n38r8n70 43 28 , , , cord-262892-n38r8n70 43 29 lymphoid lymphoid JJ cord-262892-n38r8n70 43 30 interstitial interstitial JJ cord-262892-n38r8n70 43 31 pneumonitis pneumonitis NN cord-262892-n38r8n70 43 32 , , , cord-262892-n38r8n70 43 33 recurrent recurrent JJ cord-262892-n38r8n70 43 34 bacterial bacterial JJ cord-262892-n38r8n70 43 35 infections infection NNS cord-262892-n38r8n70 43 36 , , , cord-262892-n38r8n70 43 37 and and CC cord-262892-n38r8n70 43 38 specific specific JJ cord-262892-n38r8n70 43 39 malignancies malignancy NNS cord-262892-n38r8n70 43 40 . . . cord-262892-n38r8n70 44 1 Malignancies malignancy NNS cord-262892-n38r8n70 44 2 include include VBP cord-262892-n38r8n70 44 3 non non JJ cord-262892-n38r8n70 44 4 - - JJ cord-262892-n38r8n70 44 5 Hodgkin Hodgkin NNP cord-262892-n38r8n70 44 6 B b NN cord-262892-n38r8n70 44 7 - - HYPH cord-262892-n38r8n70 44 8 cell cell NN cord-262892-n38r8n70 44 9 Burkitt Burkitt NNP cord-262892-n38r8n70 44 10 - - HYPH cord-262892-n38r8n70 44 11 type type NN cord-262892-n38r8n70 44 12 lymphomas lymphoma NNS cord-262892-n38r8n70 44 13 , , , cord-262892-n38r8n70 44 14 leiomyosarcomas leiomyosarcomas UH cord-262892-n38r8n70 44 15 , , , cord-262892-n38r8n70 44 16 and and CC cord-262892-n38r8n70 44 17 Kaposi Kaposi NNP cord-262892-n38r8n70 44 18 sarcoma sarcoma NN cord-262892-n38r8n70 44 19 , , , cord-262892-n38r8n70 44 20 which which WDT cord-262892-n38r8n70 44 21 are be VBP cord-262892-n38r8n70 44 22 commonly commonly RB cord-262892-n38r8n70 44 23 described describe VBN cord-262892-n38r8n70 44 24 in in IN cord-262892-n38r8n70 44 25 children child NNS cord-262892-n38r8n70 44 26 with with IN cord-262892-n38r8n70 44 27 HIV HIV NNP cord-262892-n38r8n70 44 28 who who WP cord-262892-n38r8n70 44 29 are be VBP cord-262892-n38r8n70 44 30 of of IN cord-262892-n38r8n70 44 31 sub sub JJ cord-262892-n38r8n70 44 32 - - JJ cord-262892-n38r8n70 44 33 Saharan saharan JJ cord-262892-n38r8n70 44 34 African african JJ cord-262892-n38r8n70 44 35 ethnicity ethnicity NN cord-262892-n38r8n70 44 36 . . . cord-262892-n38r8n70 45 1 In in IN cord-262892-n38r8n70 45 2 the the DT cord-262892-n38r8n70 45 3 United United NNP cord-262892-n38r8n70 45 4 States States NNP cord-262892-n38r8n70 45 5 , , , cord-262892-n38r8n70 45 6 in in IN cord-262892-n38r8n70 45 7 clinical clinical JJ cord-262892-n38r8n70 45 8 practice practice NN cord-262892-n38r8n70 45 9 , , , cord-262892-n38r8n70 45 10 the the DT cord-262892-n38r8n70 45 11 number number NN cord-262892-n38r8n70 45 12 of of IN cord-262892-n38r8n70 45 13 OIs OIs NNP cord-262892-n38r8n70 45 14 seen see VBN cord-262892-n38r8n70 45 15 in in IN cord-262892-n38r8n70 45 16 children child NNS cord-262892-n38r8n70 45 17 with with IN cord-262892-n38r8n70 45 18 HIV HIV NNP cord-262892-n38r8n70 45 19 has have VBZ cord-262892-n38r8n70 45 20 decreased decrease VBN cord-262892-n38r8n70 45 21 , , , cord-262892-n38r8n70 45 22 reflecting reflect VBG cord-262892-n38r8n70 45 23 the the DT cord-262892-n38r8n70 45 24 widespread widespread JJ cord-262892-n38r8n70 45 25 use use NN cord-262892-n38r8n70 45 26 and and CC cord-262892-n38r8n70 45 27 administration administration NN cord-262892-n38r8n70 45 28 of of IN cord-262892-n38r8n70 45 29 effective effective JJ cord-262892-n38r8n70 45 30 cART cART NNP cord-262892-n38r8n70 45 31 regimens regimen NNS cord-262892-n38r8n70 45 32 . . . cord-262892-n38r8n70 46 1 However however RB cord-262892-n38r8n70 46 2 , , , cord-262892-n38r8n70 46 3 OIs OIs NNP cord-262892-n38r8n70 46 4 continue continue VBP cord-262892-n38r8n70 46 5 to to TO cord-262892-n38r8n70 46 6 be be VB cord-262892-n38r8n70 46 7 the the DT cord-262892-n38r8n70 46 8 presenting present VBG cord-262892-n38r8n70 46 9 symptom symptom NN cord-262892-n38r8n70 46 10 of of IN cord-262892-n38r8n70 46 11 HIV HIV NNP cord-262892-n38r8n70 46 12 infection infection NN cord-262892-n38r8n70 46 13 in in IN cord-262892-n38r8n70 46 14 infants infant NNS cord-262892-n38r8n70 46 15 due due JJ cord-262892-n38r8n70 46 16 to to IN cord-262892-n38r8n70 46 17 lack lack NN cord-262892-n38r8n70 46 18 of of IN cord-262892-n38r8n70 46 19 antenatal antenatal JJ cord-262892-n38r8n70 46 20 testing testing NN cord-262892-n38r8n70 46 21 in in IN cord-262892-n38r8n70 46 22 mothers mother NNS cord-262892-n38r8n70 46 23 or or CC cord-262892-n38r8n70 46 24 in in IN cord-262892-n38r8n70 46 25 adolescents adolescent NNS cord-262892-n38r8n70 46 26 and and CC cord-262892-n38r8n70 46 27 young young JJ cord-262892-n38r8n70 46 28 adults adult NNS cord-262892-n38r8n70 46 29 who who WP cord-262892-n38r8n70 46 30 are be VBP cord-262892-n38r8n70 46 31 increasingly increasingly RB cord-262892-n38r8n70 46 32 infected infect VBN cord-262892-n38r8n70 46 33 through through IN cord-262892-n38r8n70 46 34 horizontal horizontal JJ cord-262892-n38r8n70 46 35 transmission transmission NN cord-262892-n38r8n70 46 36 . . . cord-262892-n38r8n70 47 1 The the DT cord-262892-n38r8n70 47 2 intestine intestine NN cord-262892-n38r8n70 47 3 is be VBZ cord-262892-n38r8n70 47 4 a a DT cord-262892-n38r8n70 47 5 primary primary JJ cord-262892-n38r8n70 47 6 target target NN cord-262892-n38r8n70 47 7 organ organ NN cord-262892-n38r8n70 47 8 for for IN cord-262892-n38r8n70 47 9 HIV HIV NNP cord-262892-n38r8n70 47 10 . . . cord-262892-n38r8n70 48 1 HIV HIV NNP cord-262892-n38r8n70 48 2 infection infection NN cord-262892-n38r8n70 48 3 causes cause VBZ cord-262892-n38r8n70 48 4 a a DT cord-262892-n38r8n70 48 5 depletion depletion NN cord-262892-n38r8n70 48 6 of of IN cord-262892-n38r8n70 48 7 CD4 CD4 NNP cord-262892-n38r8n70 48 8 + + CC cord-262892-n38r8n70 48 9 T t NN cord-262892-n38r8n70 48 10 lymphocytes lymphocyte NNS cord-262892-n38r8n70 48 11 in in IN cord-262892-n38r8n70 48 12 gut gut NN cord-262892-n38r8n70 48 13 - - HYPH cord-262892-n38r8n70 48 14 associated associate VBN cord-262892-n38r8n70 48 15 lymphoid lymphoid JJ cord-262892-n38r8n70 48 16 tissue tissue NN cord-262892-n38r8n70 48 17 , , , cord-262892-n38r8n70 48 18 including include VBG cord-262892-n38r8n70 48 19 selective selective JJ cord-262892-n38r8n70 48 20 loss loss NN cord-262892-n38r8n70 48 21 of of IN cord-262892-n38r8n70 48 22 a a DT cord-262892-n38r8n70 48 23 subset subset NN cord-262892-n38r8n70 48 24 of of IN cord-262892-n38r8n70 48 25 T T NNP cord-262892-n38r8n70 48 26 helper helper NN cord-262892-n38r8n70 48 27 cells cell NNS cord-262892-n38r8n70 48 28 called call VBN cord-262892-n38r8n70 48 29 Th17 Th17 NNP cord-262892-n38r8n70 48 30 lymphocytes lymphocyte NNS cord-262892-n38r8n70 48 31 , , , cord-262892-n38r8n70 48 32 which which WDT cord-262892-n38r8n70 48 33 are be VBP cord-262892-n38r8n70 48 34 important important JJ cord-262892-n38r8n70 48 35 in in IN cord-262892-n38r8n70 48 36 gut gut NN cord-262892-n38r8n70 48 37 mucosal mucosal JJ cord-262892-n38r8n70 48 38 containment containment NN cord-262892-n38r8n70 48 39 of of IN cord-262892-n38r8n70 48 40 extracellular extracellular JJ cord-262892-n38r8n70 48 41 pathogens pathogen NNS cord-262892-n38r8n70 48 42 such such JJ cord-262892-n38r8n70 48 43 as as IN cord-262892-n38r8n70 48 44 Salmonella Salmonella NNP cord-262892-n38r8n70 48 45 typhimurium typhimurium NN cord-262892-n38r8n70 48 46 . . . cord-262892-n38r8n70 49 1 Th17 Th17 NNP cord-262892-n38r8n70 50 1 cells cell NNS cord-262892-n38r8n70 50 2 are be VBP cord-262892-n38r8n70 50 3 lost lose VBN cord-262892-n38r8n70 50 4 early early RB cord-262892-n38r8n70 50 5 in in IN cord-262892-n38r8n70 50 6 retroviral retroviral JJ cord-262892-n38r8n70 50 7 infection infection NN cord-262892-n38r8n70 50 8 and and CC cord-262892-n38r8n70 50 9 are be VBP cord-262892-n38r8n70 50 10 not not RB cord-262892-n38r8n70 50 11 replenished replenish VBN cord-262892-n38r8n70 50 12 over over IN cord-262892-n38r8n70 50 13 time time NN cord-262892-n38r8n70 50 14 . . . cord-262892-n38r8n70 51 1 This this DT cord-262892-n38r8n70 51 2 depletion depletion NN cord-262892-n38r8n70 51 3 impairs impair VBZ cord-262892-n38r8n70 51 4 long long JJ cord-262892-n38r8n70 51 5 - - HYPH cord-262892-n38r8n70 51 6 term term NN cord-262892-n38r8n70 51 7 gastrointestinal gastrointestinal JJ cord-262892-n38r8n70 51 8 ( ( -LRB- cord-262892-n38r8n70 51 9 GI GI NNP cord-262892-n38r8n70 51 10 ) ) -RRB- cord-262892-n38r8n70 51 11 mucosal mucosal JJ cord-262892-n38r8n70 51 12 integrity integrity NN cord-262892-n38r8n70 51 13 and and CC cord-262892-n38r8n70 51 14 permeability permeability NN cord-262892-n38r8n70 51 15 , , , cord-262892-n38r8n70 51 16 causing cause VBG cord-262892-n38r8n70 51 17 increased increase VBN cord-262892-n38r8n70 51 18 bacterial bacterial JJ cord-262892-n38r8n70 51 19 translocation translocation NN cord-262892-n38r8n70 51 20 and and CC cord-262892-n38r8n70 51 21 immune immune JJ cord-262892-n38r8n70 51 22 activation activation NN cord-262892-n38r8n70 51 23 . . . cord-262892-n38r8n70 52 1 The the DT cord-262892-n38r8n70 52 2 intestinal intestinal JJ cord-262892-n38r8n70 52 3 mucosa mucosa NN cord-262892-n38r8n70 52 4 is be VBZ cord-262892-n38r8n70 52 5 also also RB cord-262892-n38r8n70 52 6 the the DT cord-262892-n38r8n70 52 7 main main JJ cord-262892-n38r8n70 52 8 reservoir reservoir NN cord-262892-n38r8n70 52 9 of of IN cord-262892-n38r8n70 52 10 HIV HIV NNP cord-262892-n38r8n70 52 11 in in IN cord-262892-n38r8n70 52 12 the the DT cord-262892-n38r8n70 52 13 body body NN cord-262892-n38r8n70 52 14 despite despite IN cord-262892-n38r8n70 52 15 effective effective JJ cord-262892-n38r8n70 52 16 virologic virologic JJ cord-262892-n38r8n70 52 17 suppression suppression NN cord-262892-n38r8n70 52 18 with with IN cord-262892-n38r8n70 52 19 cART cART NNP cord-262892-n38r8n70 52 20 . . . cord-262892-n38r8n70 53 1 Among among IN cord-262892-n38r8n70 53 2 untreated untreated JJ cord-262892-n38r8n70 53 3 children child NNS cord-262892-n38r8n70 53 4 with with IN cord-262892-n38r8n70 53 5 HIV HIV NNP cord-262892-n38r8n70 53 6 , , , cord-262892-n38r8n70 53 7 as as RB cord-262892-n38r8n70 53 8 many many JJ cord-262892-n38r8n70 53 9 as as IN cord-262892-n38r8n70 53 10 80 80 CD cord-262892-n38r8n70 53 11 % % NN cord-262892-n38r8n70 53 12 will will MD cord-262892-n38r8n70 53 13 have have VB cord-262892-n38r8n70 53 14 one one CD cord-262892-n38r8n70 53 15 or or CC cord-262892-n38r8n70 53 16 more more JJR cord-262892-n38r8n70 53 17 intestinal intestinal JJ cord-262892-n38r8n70 53 18 disorders disorder NNS cord-262892-n38r8n70 53 19 at at IN cord-262892-n38r8n70 53 20 a a DT cord-262892-n38r8n70 53 21 given give VBN cord-262892-n38r8n70 53 22 time time NN cord-262892-n38r8n70 53 23 , , , cord-262892-n38r8n70 53 24 with with IN cord-262892-n38r8n70 53 25 iron iron NN cord-262892-n38r8n70 53 26 malabsorption malabsorption NN cord-262892-n38r8n70 53 27 present present VBP cord-262892-n38r8n70 53 28 nearly nearly RB cord-262892-n38r8n70 53 29 50 50 CD cord-262892-n38r8n70 53 30 % % NN cord-262892-n38r8n70 53 31 of of IN cord-262892-n38r8n70 53 32 the the DT cord-262892-n38r8n70 53 33 time time NN cord-262892-n38r8n70 53 34 [ [ -LRB- cord-262892-n38r8n70 53 35 16 16 CD cord-262892-n38r8n70 53 36 ] ] -RRB- cord-262892-n38r8n70 53 37 . . . cord-262892-n38r8n70 54 1 HIV HIV NNP cord-262892-n38r8n70 54 2 enteropathy enteropathy NNP cord-262892-n38r8n70 54 3 is be VBZ cord-262892-n38r8n70 54 4 secondary secondary JJ cord-262892-n38r8n70 54 5 to to TO cord-262892-n38r8n70 54 6 direct direct VB cord-262892-n38r8n70 54 7 HIV HIV NNP cord-262892-n38r8n70 54 8 - - HYPH cord-262892-n38r8n70 54 9 mediated mediate VBN cord-262892-n38r8n70 54 10 injury injury NN cord-262892-n38r8n70 54 11 and and CC cord-262892-n38r8n70 54 12 indirect indirect JJ cord-262892-n38r8n70 54 13 immune immune NN cord-262892-n38r8n70 54 14 - - HYPH cord-262892-n38r8n70 54 15 mediated mediate VBN cord-262892-n38r8n70 54 16 injury injury NN cord-262892-n38r8n70 54 17 to to IN cord-262892-n38r8n70 54 18 the the DT cord-262892-n38r8n70 54 19 GI GI NNP cord-262892-n38r8n70 54 20 tract tract NN cord-262892-n38r8n70 54 21 mucosa mucosa NN cord-262892-n38r8n70 54 22 in in IN cord-262892-n38r8n70 54 23 the the DT cord-262892-n38r8n70 54 24 absence absence NN cord-262892-n38r8n70 54 25 of of IN cord-262892-n38r8n70 54 26 specific specific JJ cord-262892-n38r8n70 54 27 opportunistic opportunistic JJ cord-262892-n38r8n70 54 28 enteropathogens enteropathogen NNS cord-262892-n38r8n70 54 29 , , , cord-262892-n38r8n70 54 30 perhaps perhaps RB cord-262892-n38r8n70 54 31 reflecting reflect VBG cord-262892-n38r8n70 54 32 selective selective JJ cord-262892-n38r8n70 54 33 loss loss NN cord-262892-n38r8n70 54 34 of of IN cord-262892-n38r8n70 54 35 Th17 Th17 NNP cord-262892-n38r8n70 54 36 lymphocytes lymphocyte NNS cord-262892-n38r8n70 54 37 . . . cord-262892-n38r8n70 55 1 HIV HIV NNP cord-262892-n38r8n70 55 2 enteropathy enteropathy NNP cord-262892-n38r8n70 55 3 can can MD cord-262892-n38r8n70 55 4 occur occur VB cord-262892-n38r8n70 55 5 in in IN cord-262892-n38r8n70 55 6 children child NNS cord-262892-n38r8n70 55 7 and and CC cord-262892-n38r8n70 55 8 adolescents adolescent NNS cord-262892-n38r8n70 55 9 at at IN cord-262892-n38r8n70 55 10 all all DT cord-262892-n38r8n70 55 11 stages stage NNS cord-262892-n38r8n70 55 12 of of IN cord-262892-n38r8n70 55 13 HIV HIV NNP cord-262892-n38r8n70 55 14 infection infection NN cord-262892-n38r8n70 55 15 . . . cord-262892-n38r8n70 56 1 Clinical clinical JJ cord-262892-n38r8n70 56 2 manifestations manifestation NNS cord-262892-n38r8n70 56 3 include include VBP cord-262892-n38r8n70 56 4 chronic chronic JJ cord-262892-n38r8n70 56 5 diarrhea diarrhea NN cord-262892-n38r8n70 56 6 , , , cord-262892-n38r8n70 56 7 increased increase VBN cord-262892-n38r8n70 56 8 intestinal intestinal JJ cord-262892-n38r8n70 56 9 permeability permeability NN cord-262892-n38r8n70 56 10 , , , cord-262892-n38r8n70 56 11 malabsorption malabsorption NN cord-262892-n38r8n70 56 12 , , , cord-262892-n38r8n70 56 13 and and CC cord-262892-n38r8n70 56 14 malnutrition malnutrition NN cord-262892-n38r8n70 56 15 . . . cord-262892-n38r8n70 57 1 Histologic Histologic NNP cord-262892-n38r8n70 57 2 changes change NNS cord-262892-n38r8n70 57 3 include include VBP cord-262892-n38r8n70 57 4 lymphocytic lymphocytic JJ cord-262892-n38r8n70 57 5 infiltration infiltration NN cord-262892-n38r8n70 57 6 of of IN cord-262892-n38r8n70 57 7 the the DT cord-262892-n38r8n70 57 8 GI GI NNP cord-262892-n38r8n70 57 9 tract tract NN cord-262892-n38r8n70 57 10 mucosa mucosa NN cord-262892-n38r8n70 57 11 , , , cord-262892-n38r8n70 57 12 villous villous JJ cord-262892-n38r8n70 57 13 atrophy atrophy NN cord-262892-n38r8n70 57 14 and and CC cord-262892-n38r8n70 57 15 blunting blunting NN cord-262892-n38r8n70 57 16 , , , cord-262892-n38r8n70 57 17 and and CC cord-262892-n38r8n70 57 18 crypt crypt JJ cord-262892-n38r8n70 57 19 hyperplasia hyperplasia NN cord-262892-n38r8n70 57 20 [ [ -LRB- cord-262892-n38r8n70 57 21 17 17 CD cord-262892-n38r8n70 57 22 , , , cord-262892-n38r8n70 57 23 18 18 CD cord-262892-n38r8n70 57 24 ] ] -RRB- cord-262892-n38r8n70 57 25 . . . cord-262892-n38r8n70 58 1 A a DT cord-262892-n38r8n70 58 2 direct direct JJ cord-262892-n38r8n70 58 3 cytopathic cytopathic JJ cord-262892-n38r8n70 58 4 effect effect NN cord-262892-n38r8n70 58 5 of of IN cord-262892-n38r8n70 58 6 HIV HIV NNP cord-262892-n38r8n70 58 7 on on IN cord-262892-n38r8n70 58 8 the the DT cord-262892-n38r8n70 58 9 intestinal intestinal JJ cord-262892-n38r8n70 58 10 mucosa mucosa NN cord-262892-n38r8n70 58 11 is be VBZ cord-262892-n38r8n70 58 12 supported support VBN cord-262892-n38r8n70 58 13 by by IN cord-262892-n38r8n70 58 14 the the DT cord-262892-n38r8n70 58 15 observation observation NN cord-262892-n38r8n70 58 16 that that IN cord-262892-n38r8n70 58 17 clinical clinical JJ cord-262892-n38r8n70 58 18 signs sign NNS cord-262892-n38r8n70 58 19 and and CC cord-262892-n38r8n70 58 20 symptoms symptom NNS cord-262892-n38r8n70 58 21 improve improve VBP cord-262892-n38r8n70 58 22 after after IN cord-262892-n38r8n70 58 23 initiation initiation NN cord-262892-n38r8n70 58 24 of of IN cord-262892-n38r8n70 58 25 effective effective JJ cord-262892-n38r8n70 58 26 cART cART NNP cord-262892-n38r8n70 59 1 in in IN cord-262892-n38r8n70 59 2 association association NNP cord-262892-n38r8n70 59 3 with with IN cord-262892-n38r8n70 59 4 virologic virologic NNP cord-262892-n38r8n70 59 5 suppression suppression NN cord-262892-n38r8n70 59 6 and and CC cord-262892-n38r8n70 59 7 immune immune JJ cord-262892-n38r8n70 59 8 reconstitution reconstitution NN cord-262892-n38r8n70 59 9 of of IN cord-262892-n38r8n70 59 10 CD4 CD4 NNP cord-262892-n38r8n70 59 11 + + CC cord-262892-n38r8n70 59 12 T t NN cord-262892-n38r8n70 59 13 cells cell NNS cord-262892-n38r8n70 59 14 [ [ -LRB- cord-262892-n38r8n70 59 15 19 19 CD cord-262892-n38r8n70 59 16 ] ] -RRB- cord-262892-n38r8n70 59 17 . . . cord-262892-n38r8n70 60 1 Acute acute JJ cord-262892-n38r8n70 60 2 , , , cord-262892-n38r8n70 60 3 recurrent recurrent JJ cord-262892-n38r8n70 60 4 , , , cord-262892-n38r8n70 60 5 and and CC cord-262892-n38r8n70 60 6 chronic chronic JJ cord-262892-n38r8n70 60 7 diarrhea diarrhea NN cord-262892-n38r8n70 60 8 associated associate VBN cord-262892-n38r8n70 60 9 with with IN cord-262892-n38r8n70 60 10 malabsorption malabsorption NN cord-262892-n38r8n70 60 11 and and CC cord-262892-n38r8n70 60 12 growth growth NN cord-262892-n38r8n70 60 13 impairment impairment NN cord-262892-n38r8n70 60 14 frequently frequently RB cord-262892-n38r8n70 60 15 occur occur VBP cord-262892-n38r8n70 60 16 in in IN cord-262892-n38r8n70 60 17 children child NNS cord-262892-n38r8n70 60 18 with with IN cord-262892-n38r8n70 60 19 untreated untreated JJ cord-262892-n38r8n70 60 20 HIV HIV NNP cord-262892-n38r8n70 60 21 infection infection NN cord-262892-n38r8n70 60 22 and and CC cord-262892-n38r8n70 60 23 advancing advance VBG cord-262892-n38r8n70 60 24 immunosuppression immunosuppression NN cord-262892-n38r8n70 60 25 . . . cord-262892-n38r8n70 61 1 Commonly commonly RB cord-262892-n38r8n70 61 2 identified identify VBN cord-262892-n38r8n70 61 3 infective infective JJ cord-262892-n38r8n70 61 4 enteropathogens enteropathogen NNS cord-262892-n38r8n70 61 5 include include VBP cord-262892-n38r8n70 61 6 bacteria bacteria NNS cord-262892-n38r8n70 61 7 ( ( -LRB- cord-262892-n38r8n70 61 8 Salmonella Salmonella NNP cord-262892-n38r8n70 61 9 , , , cord-262892-n38r8n70 61 10 Shigella Shigella NNP cord-262892-n38r8n70 61 11 sp sp NN cord-262892-n38r8n70 61 12 . . NNP cord-262892-n38r8n70 61 13 ) ) -RRB- cord-262892-n38r8n70 61 14 , , , cord-262892-n38r8n70 61 15 viruses virus NNS cord-262892-n38r8n70 61 16 ( ( -LRB- cord-262892-n38r8n70 61 17 including include VBG cord-262892-n38r8n70 61 18 rotavirus rotavirus NN cord-262892-n38r8n70 61 19 , , , cord-262892-n38r8n70 61 20 adenovirus adenovirus NN cord-262892-n38r8n70 61 21 , , , cord-262892-n38r8n70 61 22 CMV CMV NNP cord-262892-n38r8n70 61 23 ) ) -RRB- cord-262892-n38r8n70 61 24 , , , cord-262892-n38r8n70 61 25 parasites parasite NNS cord-262892-n38r8n70 61 26 ( ( -LRB- cord-262892-n38r8n70 61 27 Entamoeba Entamoeba NNP cord-262892-n38r8n70 61 28 , , , cord-262892-n38r8n70 61 29 Giardia Giardia NNP cord-262892-n38r8n70 61 30 , , , cord-262892-n38r8n70 61 31 Cryptosporidia Cryptosporidia NNP cord-262892-n38r8n70 61 32 , , , cord-262892-n38r8n70 61 33 Microsporidia Microsporidia NNP cord-262892-n38r8n70 61 34 , , , cord-262892-n38r8n70 61 35 Isospora Isospora NNP cord-262892-n38r8n70 61 36 ) ) -RRB- cord-262892-n38r8n70 61 37 , , , cord-262892-n38r8n70 61 38 and and CC cord-262892-n38r8n70 61 39 opportunistic opportunistic JJ cord-262892-n38r8n70 61 40 fungi fungus NNS cord-262892-n38r8n70 61 41 [ [ -LRB- cord-262892-n38r8n70 61 42 20 20 CD cord-262892-n38r8n70 61 43 ] ] -RRB- cord-262892-n38r8n70 61 44 . . . cord-262892-n38r8n70 62 1 In in IN cord-262892-n38r8n70 62 2 children child NNS cord-262892-n38r8n70 62 3 with with IN cord-262892-n38r8n70 62 4 HIV HIV NNP cord-262892-n38r8n70 62 5 , , , cord-262892-n38r8n70 62 6 frequent frequent JJ cord-262892-n38r8n70 62 7 and and CC cord-262892-n38r8n70 62 8 persistent persistent JJ cord-262892-n38r8n70 62 9 watery watery JJ cord-262892-n38r8n70 62 10 diarrhea diarrhea NN cord-262892-n38r8n70 62 11 is be VBZ cord-262892-n38r8n70 62 12 the the DT cord-262892-n38r8n70 62 13 most most RBS cord-262892-n38r8n70 62 14 common common JJ cord-262892-n38r8n70 62 15 presentation presentation NN cord-262892-n38r8n70 62 16 of of IN cord-262892-n38r8n70 62 17 cryptosporidial cryptosporidial NNP cord-262892-n38r8n70 62 18 , , , cord-262892-n38r8n70 62 19 microsporidial microsporidial NNP cord-262892-n38r8n70 62 20 , , , cord-262892-n38r8n70 62 21 and and CC cord-262892-n38r8n70 62 22 isosporidial isosporidial JJ cord-262892-n38r8n70 62 23 infections infection NNS cord-262892-n38r8n70 62 24 , , , cord-262892-n38r8n70 62 25 associated associate VBN cord-262892-n38r8n70 62 26 with with IN cord-262892-n38r8n70 62 27 abdominal abdominal JJ cord-262892-n38r8n70 62 28 cramps cramp NNS cord-262892-n38r8n70 62 29 , , , cord-262892-n38r8n70 62 30 fever fever NN cord-262892-n38r8n70 62 31 , , , cord-262892-n38r8n70 62 32 vomiting vomiting NN cord-262892-n38r8n70 62 33 , , , cord-262892-n38r8n70 62 34 anorexia anorexia NN cord-262892-n38r8n70 62 35 , , , cord-262892-n38r8n70 62 36 weight weight NN cord-262892-n38r8n70 62 37 loss loss NN cord-262892-n38r8n70 62 38 , , , cord-262892-n38r8n70 62 39 and and CC cord-262892-n38r8n70 62 40 poor poor JJ cord-262892-n38r8n70 62 41 weight weight NN cord-262892-n38r8n70 62 42 gain gain NN cord-262892-n38r8n70 62 43 [ [ -LRB- cord-262892-n38r8n70 62 44 7 7 CD cord-262892-n38r8n70 62 45 ] ] -RRB- cord-262892-n38r8n70 62 46 . . . cord-262892-n38r8n70 63 1 Untreated untreated JJ cord-262892-n38r8n70 63 2 chronic chronic NN cord-262892-n38r8n70 63 3 severe severe JJ cord-262892-n38r8n70 63 4 diarrhea diarrhea NN cord-262892-n38r8n70 63 5 may may MD cord-262892-n38r8n70 63 6 cause cause VB cord-262892-n38r8n70 63 7 malnutrition malnutrition NN cord-262892-n38r8n70 63 8 , , , cord-262892-n38r8n70 63 9 failure failure NN cord-262892-n38r8n70 63 10 to to TO cord-262892-n38r8n70 63 11 thrive thrive VB cord-262892-n38r8n70 63 12 , , , cord-262892-n38r8n70 63 13 severe severe JJ cord-262892-n38r8n70 63 14 dehydration dehydration NN cord-262892-n38r8n70 63 15 , , , cord-262892-n38r8n70 63 16 or or CC cord-262892-n38r8n70 63 17 a a DT cord-262892-n38r8n70 63 18 combination combination NN cord-262892-n38r8n70 63 19 of of IN cord-262892-n38r8n70 63 20 all all PDT cord-262892-n38r8n70 63 21 these these DT cord-262892-n38r8n70 63 22 problems problem NNS cord-262892-n38r8n70 63 23 . . . cord-262892-n38r8n70 64 1 GI GI NNP cord-262892-n38r8n70 64 2 tract tract NN cord-262892-n38r8n70 64 3 disease disease NN cord-262892-n38r8n70 64 4 caused cause VBN cord-262892-n38r8n70 64 5 by by IN cord-262892-n38r8n70 64 6 CMV CMV NNP cord-262892-n38r8n70 64 7 may may MD cord-262892-n38r8n70 64 8 include include VB cord-262892-n38r8n70 64 9 esophagitis esophagitis NN cord-262892-n38r8n70 64 10 , , , cord-262892-n38r8n70 64 11 gastritis gastritis NN cord-262892-n38r8n70 64 12 , , , cord-262892-n38r8n70 64 13 pyloric pyloric JJ cord-262892-n38r8n70 64 14 obstruction obstruction NN cord-262892-n38r8n70 64 15 , , , cord-262892-n38r8n70 64 16 hepatitis hepatitis NN cord-262892-n38r8n70 64 17 , , , cord-262892-n38r8n70 64 18 pancreatitis pancreatitis NN cord-262892-n38r8n70 64 19 , , , cord-262892-n38r8n70 64 20 colitis colitis NN cord-262892-n38r8n70 64 21 , , , cord-262892-n38r8n70 64 22 ascending ascend VBG cord-262892-n38r8n70 64 23 cholangitis cholangitis NN cord-262892-n38r8n70 64 24 and and CC cord-262892-n38r8n70 64 25 cholecystitis cholecystitis NN cord-262892-n38r8n70 64 26 . . . cord-262892-n38r8n70 65 1 Signs sign NNS cord-262892-n38r8n70 65 2 and and CC cord-262892-n38r8n70 65 3 symptoms symptom NNS cord-262892-n38r8n70 65 4 may may MD cord-262892-n38r8n70 65 5 include include VB cord-262892-n38r8n70 65 6 nausea nausea NN cord-262892-n38r8n70 65 7 , , , cord-262892-n38r8n70 65 8 vomiting vomiting NN cord-262892-n38r8n70 65 9 , , , cord-262892-n38r8n70 65 10 dysphagia dysphagia NN cord-262892-n38r8n70 65 11 , , , cord-262892-n38r8n70 65 12 epigastric epigastric JJ cord-262892-n38r8n70 65 13 pain pain NN cord-262892-n38r8n70 65 14 , , , cord-262892-n38r8n70 65 15 icterus icterus NN cord-262892-n38r8n70 65 16 , , , cord-262892-n38r8n70 65 17 and and CC cord-262892-n38r8n70 65 18 watery watery JJ cord-262892-n38r8n70 65 19 diarrhea diarrhea NN cord-262892-n38r8n70 65 20 . . . cord-262892-n38r8n70 66 1 Stools stool NNS cord-262892-n38r8n70 66 2 may may MD cord-262892-n38r8n70 66 3 be be VB cord-262892-n38r8n70 66 4 bloody bloody JJ cord-262892-n38r8n70 66 5 . . . cord-262892-n38r8n70 67 1 Sigmoidoscopy Sigmoidoscopy NNP cord-262892-n38r8n70 67 2 in in IN cord-262892-n38r8n70 67 3 CMV CMV NNP cord-262892-n38r8n70 67 4 colitis colitis NN cord-262892-n38r8n70 67 5 provides provide VBZ cord-262892-n38r8n70 67 6 nonspecific nonspecific JJ cord-262892-n38r8n70 67 7 results result NNS cord-262892-n38r8n70 67 8 , , , cord-262892-n38r8n70 67 9 showing show VBG cord-262892-n38r8n70 67 10 diffuse diffuse JJ cord-262892-n38r8n70 67 11 erythema erythema NN cord-262892-n38r8n70 67 12 , , , cord-262892-n38r8n70 67 13 submucosal submucosal NN cord-262892-n38r8n70 67 14 hemorrhage hemorrhage NN cord-262892-n38r8n70 67 15 , , , cord-262892-n38r8n70 67 16 and and CC cord-262892-n38r8n70 67 17 diffuse diffuse VB cord-262892-n38r8n70 67 18 mucosal mucosal JJ cord-262892-n38r8n70 67 19 ulcerations ulceration NNS cord-262892-n38r8n70 67 20 . . . cord-262892-n38r8n70 68 1 Specific specific JJ cord-262892-n38r8n70 68 2 causes cause NNS cord-262892-n38r8n70 68 3 of of IN cord-262892-n38r8n70 68 4 diarrhea diarrhea NN cord-262892-n38r8n70 68 5 in in IN cord-262892-n38r8n70 68 6 representative representative JJ cord-262892-n38r8n70 68 7 adult adult NN cord-262892-n38r8n70 68 8 subjects subject NNS cord-262892-n38r8n70 68 9 with with IN cord-262892-n38r8n70 68 10 AIDS AIDS NNP cord-262892-n38r8n70 68 11 are be VBP cord-262892-n38r8n70 68 12 presented present VBN cord-262892-n38r8n70 68 13 in in IN cord-262892-n38r8n70 68 14 Table Table NNP cord-262892-n38r8n70 68 15 9 9 CD cord-262892-n38r8n70 68 16 .1 .1 . cord-262892-n38r8n70 69 1 [ [ -LRB- cord-262892-n38r8n70 69 2 21 21 CD cord-262892-n38r8n70 69 3 ] ] -RRB- cord-262892-n38r8n70 69 4 . . . cord-262892-n38r8n70 70 1 Data datum NNS cord-262892-n38r8n70 70 2 reflect reflect VBP cord-262892-n38r8n70 70 3 prospective prospective JJ cord-262892-n38r8n70 70 4 follow follow NN cord-262892-n38r8n70 70 5 - - HYPH cord-262892-n38r8n70 70 6 up up NN cord-262892-n38r8n70 70 7 of of IN cord-262892-n38r8n70 70 8 1,933 1,933 CD cord-262892-n38r8n70 70 9 participants participant NNS cord-262892-n38r8n70 70 10 in in IN cord-262892-n38r8n70 70 11 the the DT cord-262892-n38r8n70 70 12 Swiss swiss JJ cord-262892-n38r8n70 70 13 HIV HIV NNP cord-262892-n38r8n70 70 14 Cohort Cohort NNP cord-262892-n38r8n70 70 15 Study Study NNP cord-262892-n38r8n70 70 16 ; ; : cord-262892-n38r8n70 70 17 560 560 CD cord-262892-n38r8n70 70 18 diarrheal diarrheal JJ cord-262892-n38r8n70 70 19 episodes episode NNS cord-262892-n38r8n70 70 20 were be VBD cord-262892-n38r8n70 70 21 evaluated evaluate VBN cord-262892-n38r8n70 70 22 by by IN cord-262892-n38r8n70 70 23 standardized standardized JJ cord-262892-n38r8n70 70 24 stool stool NN cord-262892-n38r8n70 70 25 examination examination NN cord-262892-n38r8n70 70 26 , , , cord-262892-n38r8n70 70 27 with with IN cord-262892-n38r8n70 70 28 intestinal intestinal JJ cord-262892-n38r8n70 70 29 infections infection NNS cord-262892-n38r8n70 70 30 diagnosed diagnose VBN cord-262892-n38r8n70 70 31 in in IN cord-262892-n38r8n70 70 32 less less JJR cord-262892-n38r8n70 70 33 than than IN cord-262892-n38r8n70 70 34 50 50 CD cord-262892-n38r8n70 70 35 % % NN cord-262892-n38r8n70 70 36 of of IN cord-262892-n38r8n70 70 37 chronic chronic JJ cord-262892-n38r8n70 70 38 diarrheal diarrheal JJ cord-262892-n38r8n70 70 39 episodes episode NNS cord-262892-n38r8n70 70 40 [ [ -LRB- cord-262892-n38r8n70 70 41 22 22 CD cord-262892-n38r8n70 70 42 ] ] -RRB- cord-262892-n38r8n70 70 43 . . . cord-262892-n38r8n70 71 1 The the DT cord-262892-n38r8n70 71 2 site site NN cord-262892-n38r8n70 71 3 and and CC cord-262892-n38r8n70 71 4 severity severity NN cord-262892-n38r8n70 71 5 of of IN cord-262892-n38r8n70 71 6 infection infection NN cord-262892-n38r8n70 71 7 vary vary VBP cord-262892-n38r8n70 71 8 according accord VBG cord-262892-n38r8n70 71 9 to to IN cord-262892-n38r8n70 71 10 the the DT cord-262892-n38r8n70 71 11 infecting infect VBG cord-262892-n38r8n70 71 12 organism organism NN cord-262892-n38r8n70 71 13 . . . cord-262892-n38r8n70 72 1 Oral oral JJ cord-262892-n38r8n70 72 2 mucosal mucosal JJ cord-262892-n38r8n70 72 3 ulcerations ulceration NNS cord-262892-n38r8n70 72 4 secondary secondary JJ cord-262892-n38r8n70 72 5 to to IN cord-262892-n38r8n70 72 6 infectious infectious JJ cord-262892-n38r8n70 72 7 agents agent NNS cord-262892-n38r8n70 72 8 such such JJ cord-262892-n38r8n70 72 9 as as IN cord-262892-n38r8n70 72 10 Candida Candida NNP cord-262892-n38r8n70 72 11 albicans albican NNS cord-262892-n38r8n70 72 12 , , , cord-262892-n38r8n70 72 13 CMV CMV NNP cord-262892-n38r8n70 72 14 , , , cord-262892-n38r8n70 72 15 or or CC cord-262892-n38r8n70 72 16 HSV HSV NNP cord-262892-n38r8n70 72 17 cause cause VBP cord-262892-n38r8n70 72 18 inflammation inflammation NN cord-262892-n38r8n70 72 19 and and CC cord-262892-n38r8n70 72 20 pain pain NN cord-262892-n38r8n70 72 21 during during IN cord-262892-n38r8n70 72 22 swallowing swallowing NN cord-262892-n38r8n70 72 23 or or CC cord-262892-n38r8n70 72 24 after after IN cord-262892-n38r8n70 72 25 eating eat VBG cord-262892-n38r8n70 72 26 , , , cord-262892-n38r8n70 72 27 which which WDT cord-262892-n38r8n70 72 28 may may MD cord-262892-n38r8n70 72 29 lead lead VB cord-262892-n38r8n70 72 30 to to IN cord-262892-n38r8n70 72 31 reduced reduce VBN cord-262892-n38r8n70 72 32 oral oral JJ cord-262892-n38r8n70 72 33 intake intake NN cord-262892-n38r8n70 72 34 . . . cord-262892-n38r8n70 73 1 Opportunistic opportunistic JJ cord-262892-n38r8n70 73 2 enteropathogens enteropathogen NNS cord-262892-n38r8n70 73 3 such such JJ cord-262892-n38r8n70 73 4 as as IN cord-262892-n38r8n70 73 5 Cryptosporidium cryptosporidium NN cord-262892-n38r8n70 73 6 , , , cord-262892-n38r8n70 73 7 CMV CMV NNP cord-262892-n38r8n70 73 8 , , , cord-262892-n38r8n70 73 9 and and CC cord-262892-n38r8n70 73 10 microsporidia microsporidia NNP cord-262892-n38r8n70 73 11 [ [ -LRB- cord-262892-n38r8n70 73 12 23 23 CD cord-262892-n38r8n70 73 13 ] ] -RRB- cord-262892-n38r8n70 73 14 may may MD cord-262892-n38r8n70 73 15 affect affect VB cord-262892-n38r8n70 73 16 the the DT cord-262892-n38r8n70 73 17 hepatobiliary hepatobiliary JJ cord-262892-n38r8n70 73 18 system system NN cord-262892-n38r8n70 73 19 and and CC cord-262892-n38r8n70 73 20 pancreas pancreas NN cord-262892-n38r8n70 73 21 in in IN cord-262892-n38r8n70 73 22 addition addition NN cord-262892-n38r8n70 73 23 to to IN cord-262892-n38r8n70 73 24 the the DT cord-262892-n38r8n70 73 25 GI GI NNP cord-262892-n38r8n70 73 26 tract tract NN cord-262892-n38r8n70 73 27 , , , cord-262892-n38r8n70 73 28 resulting result VBG cord-262892-n38r8n70 73 29 in in IN cord-262892-n38r8n70 73 30 vomiting vomiting NN cord-262892-n38r8n70 73 31 , , , cord-262892-n38r8n70 73 32 abdominal abdominal JJ cord-262892-n38r8n70 73 33 pain pain NN cord-262892-n38r8n70 73 34 , , , cord-262892-n38r8n70 73 35 and and CC cord-262892-n38r8n70 73 36 malabsorption malabsorption NN cord-262892-n38r8n70 73 37 . . . cord-262892-n38r8n70 74 1 In in IN cord-262892-n38r8n70 74 2 resource resource NN cord-262892-n38r8n70 74 3 - - HYPH cord-262892-n38r8n70 74 4 limited limit VBN cord-262892-n38r8n70 74 5 settings setting NNS cord-262892-n38r8n70 74 6 , , , cord-262892-n38r8n70 74 7 disease disease NN cord-262892-n38r8n70 74 8 with with IN cord-262892-n38r8n70 74 9 Mycobacterium Mycobacterium NNP cord-262892-n38r8n70 74 10 tuberculosis tuberculosis NN cord-262892-n38r8n70 74 11 is be VBZ cord-262892-n38r8n70 74 12 the the DT cord-262892-n38r8n70 74 13 most most RBS cord-262892-n38r8n70 74 14 common common JJ cord-262892-n38r8n70 74 15 cause cause NN cord-262892-n38r8n70 74 16 of of IN cord-262892-n38r8n70 74 17 death death NN cord-262892-n38r8n70 74 18 in in IN cord-262892-n38r8n70 74 19 subjects subject NNS cord-262892-n38r8n70 74 20 with with IN cord-262892-n38r8n70 74 21 HIV HIV NNP cord-262892-n38r8n70 74 22 . . . cord-262892-n38r8n70 75 1 HIV HIV NNP cord-262892-n38r8n70 75 2 and and CC cord-262892-n38r8n70 75 3 tuberculosis tuberculosis NN cord-262892-n38r8n70 75 4 ( ( -LRB- cord-262892-n38r8n70 75 5 TB TB NNP cord-262892-n38r8n70 75 6 ) ) -RRB- cord-262892-n38r8n70 75 7 accelerate accelerate VB cord-262892-n38r8n70 75 8 disease disease NN cord-262892-n38r8n70 75 9 progression progression NN cord-262892-n38r8n70 75 10 and and CC cord-262892-n38r8n70 75 11 mortality mortality NN cord-262892-n38r8n70 75 12 and and CC cord-262892-n38r8n70 75 13 are be VBP cord-262892-n38r8n70 75 14 associated associate VBN cord-262892-n38r8n70 75 15 with with IN cord-262892-n38r8n70 75 16 marked marked JJ cord-262892-n38r8n70 75 17 clinical clinical JJ cord-262892-n38r8n70 75 18 wasting wasting NN cord-262892-n38r8n70 75 19 ; ; : cord-262892-n38r8n70 75 20 the the DT cord-262892-n38r8n70 75 21 extent extent NN cord-262892-n38r8n70 75 22 of of IN cord-262892-n38r8n70 75 23 wasting waste VBG cord-262892-n38r8n70 75 24 is be VBZ cord-262892-n38r8n70 75 25 related relate VBN cord-262892-n38r8n70 75 26 to to IN cord-262892-n38r8n70 75 27 the the DT cord-262892-n38r8n70 75 28 severity severity NN cord-262892-n38r8n70 75 29 of of IN cord-262892-n38r8n70 75 30 TB TB NNP cord-262892-n38r8n70 75 31 [ [ -LRB- cord-262892-n38r8n70 75 32 24 24 CD cord-262892-n38r8n70 75 33 ] ] -RRB- cord-262892-n38r8n70 75 34 . . . cord-262892-n38r8n70 76 1 The the DT cord-262892-n38r8n70 76 2 largest large JJS cord-262892-n38r8n70 76 3 proportion proportion NN cord-262892-n38r8n70 76 4 of of IN cord-262892-n38r8n70 76 5 newly newly RB cord-262892-n38r8n70 76 6 diagnosed diagnose VBN cord-262892-n38r8n70 76 7 children child NNS cord-262892-n38r8n70 76 8 with with IN cord-262892-n38r8n70 76 9 HIV HIV NNP cord-262892-n38r8n70 76 10 in in IN cord-262892-n38r8n70 76 11 many many JJ cord-262892-n38r8n70 76 12 US US NNP cord-262892-n38r8n70 76 13 centers center NNS cord-262892-n38r8n70 76 14 are be VBP cord-262892-n38r8n70 76 15 foreign foreign JJ cord-262892-n38r8n70 76 16 born bear VBN cord-262892-n38r8n70 76 17 and and CC cord-262892-n38r8n70 76 18 at at IN cord-262892-n38r8n70 76 19 higher high JJR cord-262892-n38r8n70 76 20 risk risk NN cord-262892-n38r8n70 76 21 of of IN cord-262892-n38r8n70 76 22 prior prior RB cord-262892-n38r8n70 76 23 and and CC cord-262892-n38r8n70 76 24 potentially potentially RB cord-262892-n38r8n70 76 25 ongoing ongoing JJ cord-262892-n38r8n70 76 26 exposure exposure NN cord-262892-n38r8n70 76 27 to to IN cord-262892-n38r8n70 76 28 TB TB NNP cord-262892-n38r8n70 76 29 . . . cord-262892-n38r8n70 77 1 TB TB NNP cord-262892-n38r8n70 77 2 is be VBZ cord-262892-n38r8n70 77 3 almost almost RB cord-262892-n38r8n70 77 4 always always RB cord-262892-n38r8n70 77 5 transmitted transmit VBN cord-262892-n38r8n70 77 6 to to IN cord-262892-n38r8n70 77 7 children child NNS cord-262892-n38r8n70 77 8 by by IN cord-262892-n38r8n70 77 9 an an DT cord-262892-n38r8n70 77 10 adult adult NN cord-262892-n38r8n70 77 11 , , , cord-262892-n38r8n70 77 12 most most RBS cord-262892-n38r8n70 77 13 commonly commonly RB cord-262892-n38r8n70 77 14 a a DT cord-262892-n38r8n70 77 15 household household NN cord-262892-n38r8n70 77 16 contact contact NN cord-262892-n38r8n70 77 17 , , , cord-262892-n38r8n70 77 18 and and CC cord-262892-n38r8n70 77 19 the the DT cord-262892-n38r8n70 77 20 infection infection NN cord-262892-n38r8n70 77 21 in in IN cord-262892-n38r8n70 77 22 children child NNS cord-262892-n38r8n70 77 23 is be VBZ cord-262892-n38r8n70 77 24 primary primary JJ cord-262892-n38r8n70 77 25 infection infection NN cord-262892-n38r8n70 77 26 rather rather RB cord-262892-n38r8n70 77 27 than than IN cord-262892-n38r8n70 77 28 reactivated reactivate VBN cord-262892-n38r8n70 77 29 disease disease NN cord-262892-n38r8n70 77 30 as as IN cord-262892-n38r8n70 77 31 in in IN cord-262892-n38r8n70 77 32 adults adult NNS cord-262892-n38r8n70 77 33 . . . cord-262892-n38r8n70 78 1 There there EX cord-262892-n38r8n70 78 2 should should MD cord-262892-n38r8n70 78 3 be be VB cord-262892-n38r8n70 78 4 an an DT cord-262892-n38r8n70 78 5 increased increase VBN cord-262892-n38r8n70 78 6 index index NN cord-262892-n38r8n70 78 7 of of IN cord-262892-n38r8n70 78 8 suspicion suspicion NN cord-262892-n38r8n70 78 9 of of IN cord-262892-n38r8n70 78 10 TB TB NNP cord-262892-n38r8n70 78 11 infection infection NN cord-262892-n38r8n70 78 12 and and CC cord-262892-n38r8n70 78 13 disease disease NN cord-262892-n38r8n70 78 14 in in IN cord-262892-n38r8n70 78 15 children child NNS cord-262892-n38r8n70 78 16 with with IN cord-262892-n38r8n70 78 17 HIV HIV NNP cord-262892-n38r8n70 78 18 , , , cord-262892-n38r8n70 78 19 particularly particularly RB cord-262892-n38r8n70 78 20 in in IN cord-262892-n38r8n70 78 21 the the DT cord-262892-n38r8n70 78 22 context context NN cord-262892-n38r8n70 78 23 of of IN cord-262892-n38r8n70 78 24 clinical clinical JJ cord-262892-n38r8n70 78 25 wasting wasting NN cord-262892-n38r8n70 78 26 and and CC cord-262892-n38r8n70 78 27 a a DT cord-262892-n38r8n70 78 28 low low JJ cord-262892-n38r8n70 78 29 threshold threshold NN cord-262892-n38r8n70 78 30 for for IN cord-262892-n38r8n70 78 31 empiric empiric JJ cord-262892-n38r8n70 78 32 antituberculosis antituberculosis NN cord-262892-n38r8n70 78 33 therapy therapy NN cord-262892-n38r8n70 78 34 , , , cord-262892-n38r8n70 78 35 even even RB cord-262892-n38r8n70 78 36 when when WRB cord-262892-n38r8n70 78 37 diagnostic diagnostic JJ cord-262892-n38r8n70 78 38 investigations investigation NNS cord-262892-n38r8n70 78 39 fail fail VBP cord-262892-n38r8n70 78 40 to to TO cord-262892-n38r8n70 78 41 identify identify VB cord-262892-n38r8n70 78 42 a a DT cord-262892-n38r8n70 78 43 TB TB NNP cord-262892-n38r8n70 78 44 - - HYPH cord-262892-n38r8n70 78 45 causing cause VBG cord-262892-n38r8n70 78 46 organism organism NN cord-262892-n38r8n70 78 47 . . . cord-262892-n38r8n70 79 1 The the DT cord-262892-n38r8n70 79 2 combination combination NN cord-262892-n38r8n70 79 3 of of IN cord-262892-n38r8n70 79 4 underlying underlie VBG cord-262892-n38r8n70 79 5 HIV HIV NNP cord-262892-n38r8n70 79 6 infection infection NN cord-262892-n38r8n70 79 7 , , , cord-262892-n38r8n70 79 8 nutritional nutritional JJ cord-262892-n38r8n70 79 9 status status NN cord-262892-n38r8n70 79 10 ( ( -LRB- cord-262892-n38r8n70 79 11 particularly particularly RB cord-262892-n38r8n70 79 12 protein protein NN cord-262892-n38r8n70 79 13 - - HYPH cord-262892-n38r8n70 79 14 energy energy NN cord-262892-n38r8n70 79 15 malnutrition malnutrition NN cord-262892-n38r8n70 79 16 ) ) -RRB- cord-262892-n38r8n70 79 17 , , , cord-262892-n38r8n70 79 18 and and CC cord-262892-n38r8n70 79 19 host host NN cord-262892-n38r8n70 79 20 immunity immunity NN cord-262892-n38r8n70 79 21 are be VBP cord-262892-n38r8n70 79 22 inextricably inextricably RB cord-262892-n38r8n70 79 23 interdependent interdependent JJ cord-262892-n38r8n70 79 24 . . . cord-262892-n38r8n70 80 1 In in IN cord-262892-n38r8n70 80 2 the the DT cord-262892-n38r8n70 80 3 United United NNP cord-262892-n38r8n70 80 4 States States NNP cord-262892-n38r8n70 80 5 , , , cord-262892-n38r8n70 80 6 prior prior RB cord-262892-n38r8n70 80 7 to to IN cord-262892-n38r8n70 80 8 the the DT cord-262892-n38r8n70 80 9 widespread widespread JJ cord-262892-n38r8n70 80 10 administration administration NN cord-262892-n38r8n70 80 11 of of IN cord-262892-n38r8n70 80 12 effective effective JJ cord-262892-n38r8n70 80 13 cART cART NNP cord-262892-n38r8n70 80 14 , , , cord-262892-n38r8n70 80 15 the the DT cord-262892-n38r8n70 80 16 predominant predominant JJ cord-262892-n38r8n70 80 17 effect effect NN cord-262892-n38r8n70 80 18 of of IN cord-262892-n38r8n70 80 19 advancing advance VBG cord-262892-n38r8n70 80 20 immunosuppression immunosuppression NN cord-262892-n38r8n70 80 21 on on IN cord-262892-n38r8n70 80 22 nutritional nutritional JJ cord-262892-n38r8n70 80 23 status status NN cord-262892-n38r8n70 80 24 in in IN cord-262892-n38r8n70 80 25 children child NNS cord-262892-n38r8n70 80 26 with with IN cord-262892-n38r8n70 80 27 HIV HIV NNP cord-262892-n38r8n70 80 28 was be VBD cord-262892-n38r8n70 80 29 wasting waste VBG cord-262892-n38r8n70 80 30 and and CC cord-262892-n38r8n70 80 31 negative negative JJ cord-262892-n38r8n70 80 32 energy energy NN cord-262892-n38r8n70 80 33 balance balance NN cord-262892-n38r8n70 80 34 , , , cord-262892-n38r8n70 80 35 which which WDT cord-262892-n38r8n70 80 36 predicted predict VBD cord-262892-n38r8n70 80 37 both both CC cord-262892-n38r8n70 80 38 morbidity morbidity NN cord-262892-n38r8n70 80 39 and and CC cord-262892-n38r8n70 80 40 mortality mortality NN cord-262892-n38r8n70 80 41 [ [ -LRB- cord-262892-n38r8n70 80 42 25 25 CD cord-262892-n38r8n70 80 43 ] ] -RRB- cord-262892-n38r8n70 80 44 . . . cord-262892-n38r8n70 81 1 In in IN cord-262892-n38r8n70 81 2 the the DT cord-262892-n38r8n70 81 3 pre pre JJ cord-262892-n38r8n70 81 4 - - JJ cord-262892-n38r8n70 81 5 cART cart JJ cord-262892-n38r8n70 81 6 era era NN cord-262892-n38r8n70 81 7 , , , cord-262892-n38r8n70 81 8 OIs OIs NNP cord-262892-n38r8n70 81 9 were be VBD cord-262892-n38r8n70 81 10 major major JJ cord-262892-n38r8n70 81 11 precipitants precipitant NNS cord-262892-n38r8n70 81 12 of of IN cord-262892-n38r8n70 81 13 weight weight NN cord-262892-n38r8n70 81 14 loss loss NN cord-262892-n38r8n70 81 15 , , , cord-262892-n38r8n70 81 16 necessitating necessitate VBG cord-262892-n38r8n70 81 17 prevention prevention NN cord-262892-n38r8n70 81 18 or or CC cord-262892-n38r8n70 81 19 prompt prompt JJ cord-262892-n38r8n70 81 20 diagnosis diagnosis NN cord-262892-n38r8n70 81 21 and and CC cord-262892-n38r8n70 81 22 treatment treatment NN cord-262892-n38r8n70 81 23 to to TO cord-262892-n38r8n70 81 24 prevent prevent VB cord-262892-n38r8n70 81 25 wasting wasting NN cord-262892-n38r8n70 81 26 and and CC cord-262892-n38r8n70 81 27 to to TO cord-262892-n38r8n70 81 28 promote promote VB cord-262892-n38r8n70 81 29 weight weight NN cord-262892-n38r8n70 81 30 recovery recovery NN cord-262892-n38r8n70 81 31 [ [ -LRB- cord-262892-n38r8n70 81 32 26 26 CD cord-262892-n38r8n70 81 33 ] ] -RRB- cord-262892-n38r8n70 81 34 . . . cord-262892-n38r8n70 82 1 Growth growth NN cord-262892-n38r8n70 82 2 in in IN cord-262892-n38r8n70 82 3 children child NNS cord-262892-n38r8n70 82 4 with with IN cord-262892-n38r8n70 82 5 HIV HIV NNP cord-262892-n38r8n70 82 6 was be VBD cord-262892-n38r8n70 82 7 persistently persistently RB cord-262892-n38r8n70 82 8 below below IN cord-262892-n38r8n70 82 9 normal normal JJ cord-262892-n38r8n70 82 10 standards standard NNS cord-262892-n38r8n70 82 11 , , , cord-262892-n38r8n70 82 12 with with IN cord-262892-n38r8n70 82 13 reduced reduce VBN cord-262892-n38r8n70 82 14 height height NN cord-262892-n38r8n70 82 15 and and CC cord-262892-n38r8n70 82 16 weight weight NN cord-262892-n38r8n70 82 17 velocities velocity NNS cord-262892-n38r8n70 82 18 , , , cord-262892-n38r8n70 82 19 compared compare VBN cord-262892-n38r8n70 82 20 with with IN cord-262892-n38r8n70 82 21 HIV HIV NNP cord-262892-n38r8n70 82 22 - - HYPH cord-262892-n38r8n70 82 23 exposed expose VBN cord-262892-n38r8n70 82 24 but but CC cord-262892-n38r8n70 82 25 uninfected uninfected JJ cord-262892-n38r8n70 82 26 children child NNS cord-262892-n38r8n70 82 27 . . . cord-262892-n38r8n70 83 1 In in IN cord-262892-n38r8n70 83 2 1994 1994 CD cord-262892-n38r8n70 83 3 , , , cord-262892-n38r8n70 83 4 the the DT cord-262892-n38r8n70 83 5 Centers Centers NNPS cord-262892-n38r8n70 83 6 for for IN cord-262892-n38r8n70 83 7 Disease Disease NNP cord-262892-n38r8n70 83 8 Control Control NNP cord-262892-n38r8n70 83 9 and and CC cord-262892-n38r8n70 83 10 Prevention Prevention NNP cord-262892-n38r8n70 83 11 ( ( -LRB- cord-262892-n38r8n70 83 12 CDC CDC NNP cord-262892-n38r8n70 83 13 ) ) -RRB- cord-262892-n38r8n70 83 14 defined define VBD cord-262892-n38r8n70 83 15 wasting wasting NN cord-262892-n38r8n70 83 16 in in IN cord-262892-n38r8n70 83 17 children child NNS cord-262892-n38r8n70 83 18 younger young JJR cord-262892-n38r8n70 83 19 than than IN cord-262892-n38r8n70 83 20 age age NN cord-262892-n38r8n70 83 21 13 13 CD cord-262892-n38r8n70 83 22 years year NNS cord-262892-n38r8n70 83 23 as as IN cord-262892-n38r8n70 83 24 ( ( -LRB- cord-262892-n38r8n70 83 25 1 1 CD cord-262892-n38r8n70 83 26 ) ) -RRB- cord-262892-n38r8n70 83 27 persistent persistent JJ cord-262892-n38r8n70 83 28 weight weight NN cord-262892-n38r8n70 83 29 loss loss NN cord-262892-n38r8n70 83 30 of of IN cord-262892-n38r8n70 83 31 more more JJR cord-262892-n38r8n70 83 32 than than IN cord-262892-n38r8n70 83 33 10 10 CD cord-262892-n38r8n70 83 34 % % NN cord-262892-n38r8n70 83 35 of of IN cord-262892-n38r8n70 83 36 baseline baseline NN cord-262892-n38r8n70 83 37 ; ; : cord-262892-n38r8n70 83 38 ( ( -LRB- cord-262892-n38r8n70 83 39 2 2 LS cord-262892-n38r8n70 83 40 ) ) -RRB- cord-262892-n38r8n70 83 41 downward downward JJ cord-262892-n38r8n70 83 42 crossing crossing NN cord-262892-n38r8n70 83 43 of of IN cord-262892-n38r8n70 83 44 at at RB cord-262892-n38r8n70 83 45 least least RBS cord-262892-n38r8n70 83 46 two two CD cord-262892-n38r8n70 83 47 percentile percentile JJ cord-262892-n38r8n70 83 48 lines line NNS cord-262892-n38r8n70 83 49 on on IN cord-262892-n38r8n70 83 50 the the DT cord-262892-n38r8n70 83 51 weight weight NN cord-262892-n38r8n70 83 52 - - HYPH cord-262892-n38r8n70 83 53 for for IN cord-262892-n38r8n70 83 54 - - HYPH cord-262892-n38r8n70 83 55 age age NN cord-262892-n38r8n70 83 56 chart chart NN cord-262892-n38r8n70 83 57 in in IN cord-262892-n38r8n70 83 58 a a DT cord-262892-n38r8n70 83 59 child child NN cord-262892-n38r8n70 83 60 aged age VBN cord-262892-n38r8n70 83 61 1 1 CD cord-262892-n38r8n70 83 62 year year NN cord-262892-n38r8n70 83 63 or or CC cord-262892-n38r8n70 83 64 older old JJR cord-262892-n38r8n70 83 65 ; ; : cord-262892-n38r8n70 83 66 or or CC cord-262892-n38r8n70 83 67 ( ( -LRB- cord-262892-n38r8n70 83 68 3 3 LS cord-262892-n38r8n70 83 69 ) ) -RRB- cord-262892-n38r8n70 83 70 less less JJR cord-262892-n38r8n70 83 71 than than IN cord-262892-n38r8n70 83 72 the the DT cord-262892-n38r8n70 83 73 5th 5th JJ cord-262892-n38r8n70 83 74 percentile percentile NN cord-262892-n38r8n70 83 75 on on IN cord-262892-n38r8n70 83 76 the the DT cord-262892-n38r8n70 83 77 weight weight NN cord-262892-n38r8n70 83 78 - - HYPH cord-262892-n38r8n70 83 79 for for IN cord-262892-n38r8n70 83 80 - - HYPH cord-262892-n38r8n70 83 81 height height NN cord-262892-n38r8n70 83 82 chart chart NN cord-262892-n38r8n70 83 83 on on IN cord-262892-n38r8n70 83 84 two two CD cord-262892-n38r8n70 83 85 consecutive consecutive JJ cord-262892-n38r8n70 83 86 measurements measurement NNS cord-262892-n38r8n70 83 87 at at IN cord-262892-n38r8n70 83 88 least least JJS cord-262892-n38r8n70 83 89 30 30 CD cord-262892-n38r8n70 83 90 days day NNS cord-262892-n38r8n70 83 91 apart apart RB cord-262892-n38r8n70 83 92 , , , cord-262892-n38r8n70 83 93 plus plus CC cord-262892-n38r8n70 83 94 chronic chronic JJ cord-262892-n38r8n70 83 95 diarrhea diarrhea NN cord-262892-n38r8n70 83 96 or or CC cord-262892-n38r8n70 83 97 documented document VBN cord-262892-n38r8n70 83 98 fever fever NN cord-262892-n38r8n70 83 99 for for IN cord-262892-n38r8n70 83 100 at at RB cord-262892-n38r8n70 83 101 least least RBS cord-262892-n38r8n70 83 102 30 30 CD cord-262892-n38r8n70 83 103 days day NNS cord-262892-n38r8n70 83 104 , , , cord-262892-n38r8n70 83 105 whether whether IN cord-262892-n38r8n70 83 106 intermittent intermittent JJ cord-262892-n38r8n70 83 107 or or CC cord-262892-n38r8n70 83 108 constant constant JJ cord-262892-n38r8n70 83 109 [ [ -LRB- cord-262892-n38r8n70 83 110 27 27 CD cord-262892-n38r8n70 83 111 ] ] -RRB- cord-262892-n38r8n70 83 112 . . . cord-262892-n38r8n70 84 1 In in IN cord-262892-n38r8n70 84 2 addition addition NN cord-262892-n38r8n70 84 3 to to IN cord-262892-n38r8n70 84 4 OIs OIs NNP cord-262892-n38r8n70 84 5 , , , cord-262892-n38r8n70 84 6 other other JJ cord-262892-n38r8n70 84 7 etiologies etiology NNS cord-262892-n38r8n70 84 8 that that WDT cord-262892-n38r8n70 84 9 contribute contribute VBP cord-262892-n38r8n70 84 10 to to IN cord-262892-n38r8n70 84 11 abnormal abnormal JJ cord-262892-n38r8n70 84 12 growth growth NN cord-262892-n38r8n70 84 13 in in IN cord-262892-n38r8n70 84 14 untreated untreated JJ cord-262892-n38r8n70 84 15 HIV HIV NNP cord-262892-n38r8n70 84 16 infection infection NN cord-262892-n38r8n70 84 17 in in IN cord-262892-n38r8n70 84 18 children child NNS cord-262892-n38r8n70 84 19 include include VBP cord-262892-n38r8n70 84 20 a a DT cord-262892-n38r8n70 84 21 synergistic synergistic JJ cord-262892-n38r8n70 84 22 combination combination NN cord-262892-n38r8n70 84 23 of of IN cord-262892-n38r8n70 84 24 inadequate inadequate JJ cord-262892-n38r8n70 84 25 dietary dietary JJ cord-262892-n38r8n70 84 26 intake intake NN cord-262892-n38r8n70 84 27 , , , cord-262892-n38r8n70 84 28 GI GI NNP cord-262892-n38r8n70 84 29 malabsorption malabsorption NN cord-262892-n38r8n70 84 30 , , , cord-262892-n38r8n70 84 31 increased increase VBN cord-262892-n38r8n70 84 32 energy energy NN cord-262892-n38r8n70 84 33 utilization utilization NN cord-262892-n38r8n70 84 34 , , , cord-262892-n38r8n70 84 35 and and CC cord-262892-n38r8n70 84 36 socioeconomic socioeconomic JJ cord-262892-n38r8n70 84 37 adversity adversity NN cord-262892-n38r8n70 84 38 . . . cord-262892-n38r8n70 85 1 The the DT cord-262892-n38r8n70 85 2 prevalence prevalence NN cord-262892-n38r8n70 85 3 of of IN cord-262892-n38r8n70 85 4 malnutrition malnutrition NN cord-262892-n38r8n70 85 5 in in IN cord-262892-n38r8n70 85 6 children child NNS cord-262892-n38r8n70 85 7 with with IN cord-262892-n38r8n70 85 8 HIV HIV NNP cord-262892-n38r8n70 85 9 varied varied JJ cord-262892-n38r8n70 85 10 among among IN cord-262892-n38r8n70 85 11 centers center NNS cord-262892-n38r8n70 85 12 in in IN cord-262892-n38r8n70 85 13 the the DT cord-262892-n38r8n70 85 14 United United NNP cord-262892-n38r8n70 85 15 States States NNP cord-262892-n38r8n70 85 16 with with IN cord-262892-n38r8n70 85 17 up up IN cord-262892-n38r8n70 85 18 to to TO cord-262892-n38r8n70 85 19 30 30 CD cord-262892-n38r8n70 85 20 - - SYM cord-262892-n38r8n70 85 21 50 50 CD cord-262892-n38r8n70 85 22 % % NN cord-262892-n38r8n70 85 23 of of IN cord-262892-n38r8n70 85 24 children child NNS cord-262892-n38r8n70 85 25 followed follow VBD cord-262892-n38r8n70 85 26 up up RP cord-262892-n38r8n70 85 27 in in IN cord-262892-n38r8n70 85 28 pediatric pediatric JJ cord-262892-n38r8n70 85 29 HIV HIV NNP cord-262892-n38r8n70 85 30 programs program NNS cord-262892-n38r8n70 85 31 having have VBG cord-262892-n38r8n70 85 32 demonstrable demonstrable JJ cord-262892-n38r8n70 85 33 evidence evidence NN cord-262892-n38r8n70 85 34 of of IN cord-262892-n38r8n70 85 35 protein protein NN cord-262892-n38r8n70 85 36 - - HYPH cord-262892-n38r8n70 85 37 energy energy NN cord-262892-n38r8n70 85 38 malnutrition malnutrition NN cord-262892-n38r8n70 85 39 , , , cord-262892-n38r8n70 85 40 which which WDT cord-262892-n38r8n70 85 41 , , , cord-262892-n38r8n70 85 42 in in IN cord-262892-n38r8n70 85 43 turn turn NN cord-262892-n38r8n70 85 44 , , , cord-262892-n38r8n70 85 45 exacerbated exacerbate VBD cord-262892-n38r8n70 85 46 the the DT cord-262892-n38r8n70 85 47 immunosuppressive immunosuppressive JJ cord-262892-n38r8n70 85 48 effects effect NNS cord-262892-n38r8n70 85 49 of of IN cord-262892-n38r8n70 85 50 HIV HIV NNP cord-262892-n38r8n70 85 51 [ [ -LRB- cord-262892-n38r8n70 85 52 28 28 CD cord-262892-n38r8n70 85 53 ] ] -RRB- cord-262892-n38r8n70 85 54 . . . cord-262892-n38r8n70 86 1 Common common JJ cord-262892-n38r8n70 86 2 patterns pattern NNS cord-262892-n38r8n70 86 3 of of IN cord-262892-n38r8n70 86 4 wasting waste VBG cord-262892-n38r8n70 86 5 included include VBD cord-262892-n38r8n70 86 6 an an DT cord-262892-n38r8n70 86 7 early early JJ cord-262892-n38r8n70 86 8 decline decline NN cord-262892-n38r8n70 86 9 in in IN cord-262892-n38r8n70 86 10 weight weight NN cord-262892-n38r8n70 86 11 and and CC cord-262892-n38r8n70 86 12 height height NN cord-262892-n38r8n70 86 13 in in IN cord-262892-n38r8n70 86 14 the the DT cord-262892-n38r8n70 86 15 first first JJ cord-262892-n38r8n70 86 16 3 3 CD cord-262892-n38r8n70 86 17 months month NNS cord-262892-n38r8n70 86 18 of of IN cord-262892-n38r8n70 86 19 life life NN cord-262892-n38r8n70 86 20 or or CC cord-262892-n38r8n70 86 21 early early JJ cord-262892-n38r8n70 86 22 linear linear JJ cord-262892-n38r8n70 86 23 stunting stunting NN cord-262892-n38r8n70 86 24 with with IN cord-262892-n38r8n70 86 25 a a DT cord-262892-n38r8n70 86 26 normal normal JJ cord-262892-n38r8n70 86 27 weight weight NN cord-262892-n38r8n70 86 28 - - HYPH cord-262892-n38r8n70 86 29 to to IN cord-262892-n38r8n70 86 30 - - HYPH cord-262892-n38r8n70 86 31 height height NN cord-262892-n38r8n70 86 32 ratio ratio NN cord-262892-n38r8n70 86 33 . . . cord-262892-n38r8n70 87 1 Progressive progressive JJ cord-262892-n38r8n70 87 2 wasting waste VBG cord-262892-n38r8n70 87 3 with with IN cord-262892-n38r8n70 87 4 low low JJ cord-262892-n38r8n70 87 5 weights weight NNS cord-262892-n38r8n70 87 6 and and CC cord-262892-n38r8n70 87 7 heights height NNS cord-262892-n38r8n70 87 8 were be VBD cord-262892-n38r8n70 87 9 also also RB cord-262892-n38r8n70 87 10 well well RB cord-262892-n38r8n70 87 11 recognized recognize VBN cord-262892-n38r8n70 87 12 and and CC cord-262892-n38r8n70 87 13 more more RBR cord-262892-n38r8n70 87 14 commonly commonly RB cord-262892-n38r8n70 87 15 associated associate VBN cord-262892-n38r8n70 87 16 with with IN cord-262892-n38r8n70 87 17 infectious infectious JJ cord-262892-n38r8n70 87 18 enteropathogens enteropathogen NNS cord-262892-n38r8n70 87 19 . . . cord-262892-n38r8n70 88 1 Sequential sequential JJ cord-262892-n38r8n70 88 2 follow follow NN cord-262892-n38r8n70 88 3 - - HYPH cord-262892-n38r8n70 88 4 up up NN cord-262892-n38r8n70 88 5 demonstrated demonstrate VBD cord-262892-n38r8n70 88 6 that that IN cord-262892-n38r8n70 88 7 growth growth NN cord-262892-n38r8n70 88 8 in in IN cord-262892-n38r8n70 88 9 children child NNS cord-262892-n38r8n70 88 10 with with IN cord-262892-n38r8n70 88 11 untreated untreated JJ cord-262892-n38r8n70 88 12 HIV HIV NNP cord-262892-n38r8n70 88 13 infection infection NN cord-262892-n38r8n70 88 14 remained remain VBD cord-262892-n38r8n70 88 15 below below IN cord-262892-n38r8n70 88 16 growth growth NN cord-262892-n38r8n70 88 17 in in IN cord-262892-n38r8n70 88 18 age age NN cord-262892-n38r8n70 88 19 - - HYPH cord-262892-n38r8n70 88 20 matched match VBN cord-262892-n38r8n70 88 21 and and CC cord-262892-n38r8n70 88 22 gender gender NN cord-262892-n38r8n70 88 23 - - HYPH cord-262892-n38r8n70 88 24 matched match VBN cord-262892-n38r8n70 88 25 uninfected uninfected JJ cord-262892-n38r8n70 88 26 controls control NNS cord-262892-n38r8n70 88 27 . . . cord-262892-n38r8n70 89 1 Malabsorption malabsorption NN cord-262892-n38r8n70 89 2 also also RB cord-262892-n38r8n70 89 3 results result VBZ cord-262892-n38r8n70 89 4 in in IN cord-262892-n38r8n70 89 5 macronutrient macronutrient NN cord-262892-n38r8n70 89 6 and and CC cord-262892-n38r8n70 89 7 micronutrient micronutrient NN cord-262892-n38r8n70 89 8 deficiencies deficiency NNS cord-262892-n38r8n70 89 9 . . . cord-262892-n38r8n70 90 1 Micronutrient Micronutrient NNP cord-262892-n38r8n70 90 2 deficiencies deficiency NNS cord-262892-n38r8n70 90 3 are be VBP cord-262892-n38r8n70 90 4 widespread widespread JJ cord-262892-n38r8n70 90 5 and and CC cord-262892-n38r8n70 90 6 compound compound VB cord-262892-n38r8n70 90 7 the the DT cord-262892-n38r8n70 90 8 effects effect NNS cord-262892-n38r8n70 90 9 of of IN cord-262892-n38r8n70 90 10 HIV HIV NNP cord-262892-n38r8n70 90 11 infection infection NN cord-262892-n38r8n70 90 12 in in IN cord-262892-n38r8n70 90 13 children child NNS cord-262892-n38r8n70 90 14 . . . cord-262892-n38r8n70 91 1 Deficiency deficiency NN cord-262892-n38r8n70 91 2 can can MD cord-262892-n38r8n70 91 3 manifest manifest VB cord-262892-n38r8n70 91 4 in in IN cord-262892-n38r8n70 91 5 conditions condition NNS cord-262892-n38r8n70 91 6 such such JJ cord-262892-n38r8n70 91 7 as as IN cord-262892-n38r8n70 91 8 fatigue fatigue NN cord-262892-n38r8n70 91 9 , , , cord-262892-n38r8n70 91 10 reduced reduce VBN cord-262892-n38r8n70 91 11 learning learning NN cord-262892-n38r8n70 91 12 ability ability NN cord-262892-n38r8n70 91 13 due due IN cord-262892-n38r8n70 91 14 to to IN cord-262892-n38r8n70 91 15 anemia anemia NN cord-262892-n38r8n70 91 16 ( ( -LRB- cord-262892-n38r8n70 91 17 iron iron NN cord-262892-n38r8n70 91 18 deficiency deficiency NN cord-262892-n38r8n70 91 19 ) ) -RRB- cord-262892-n38r8n70 91 20 , , , cord-262892-n38r8n70 91 21 and and CC cord-262892-n38r8n70 91 22 impaired impaired JJ cord-262892-n38r8n70 91 23 immunity immunity NN cord-262892-n38r8n70 91 24 [ [ -LRB- cord-262892-n38r8n70 91 25 29 29 CD cord-262892-n38r8n70 91 26 ] ] -RRB- cord-262892-n38r8n70 91 27 . . . cord-262892-n38r8n70 92 1 Such such JJ cord-262892-n38r8n70 92 2 deficiencies deficiency NNS cord-262892-n38r8n70 92 3 reflect reflect VBP cord-262892-n38r8n70 92 4 inadequate inadequate JJ cord-262892-n38r8n70 92 5 nutrient nutrient NN cord-262892-n38r8n70 92 6 intake intake NN cord-262892-n38r8n70 92 7 and and CC cord-262892-n38r8n70 92 8 the the DT cord-262892-n38r8n70 92 9 consequences consequence NNS cord-262892-n38r8n70 92 10 of of IN cord-262892-n38r8n70 92 11 excessive excessive JJ cord-262892-n38r8n70 92 12 losses loss NNS cord-262892-n38r8n70 92 13 due due JJ cord-262892-n38r8n70 92 14 to to IN cord-262892-n38r8n70 92 15 OIs OIs NNP cord-262892-n38r8n70 92 16 , , , cord-262892-n38r8n70 92 17 diarrhea diarrhea NN cord-262892-n38r8n70 92 18 , , , cord-262892-n38r8n70 92 19 and and CC cord-262892-n38r8n70 92 20 malabsorption malabsorption NN cord-262892-n38r8n70 92 21 , , , cord-262892-n38r8n70 92 22 as as IN cord-262892-n38r8n70 92 23 previously previously RB cord-262892-n38r8n70 92 24 described describe VBN cord-262892-n38r8n70 92 25 . . . cord-262892-n38r8n70 93 1 Other other JJ cord-262892-n38r8n70 93 2 micronutrients micronutrient NNS cord-262892-n38r8n70 93 3 that that WDT cord-262892-n38r8n70 93 4 can can MD cord-262892-n38r8n70 93 5 also also RB cord-262892-n38r8n70 93 6 be be VB cord-262892-n38r8n70 93 7 malabsorbed malabsorbed JJ cord-262892-n38r8n70 93 8 resulting result VBG cord-262892-n38r8n70 93 9 in in IN cord-262892-n38r8n70 93 10 deficiency deficiency NN cord-262892-n38r8n70 93 11 include include VBP cord-262892-n38r8n70 93 12 vitamin vitamin NN cord-262892-n38r8n70 93 13 B12 b12 NN cord-262892-n38r8n70 93 14 , , , cord-262892-n38r8n70 93 15 folic folic JJ cord-262892-n38r8n70 93 16 acid acid NN cord-262892-n38r8n70 93 17 , , , cord-262892-n38r8n70 93 18 thiamine thiamine NN cord-262892-n38r8n70 93 19 , , , cord-262892-n38r8n70 93 20 zinc zinc NN cord-262892-n38r8n70 93 21 , , , cord-262892-n38r8n70 93 22 selenium selenium NN cord-262892-n38r8n70 93 23 , , , cord-262892-n38r8n70 93 24 calcium calcium NN cord-262892-n38r8n70 93 25 , , , cord-262892-n38r8n70 93 26 and and CC cord-262892-n38r8n70 93 27 magnesium magnesium NN cord-262892-n38r8n70 93 28 , , , cord-262892-n38r8n70 93 29 and and CC cord-262892-n38r8n70 93 30 fat fat JJ cord-262892-n38r8n70 93 31 - - HYPH cord-262892-n38r8n70 93 32 soluble soluble JJ cord-262892-n38r8n70 93 33 vitamins vitamin NNS cord-262892-n38r8n70 93 34 A a VBP cord-262892-n38r8n70 93 35 and and CC cord-262892-n38r8n70 93 36 D d JJ cord-262892-n38r8n70 93 37 [ [ -LRB- cord-262892-n38r8n70 93 38 21 21 CD cord-262892-n38r8n70 93 39 ] ] -RRB- cord-262892-n38r8n70 93 40 . . . cord-262892-n38r8n70 94 1 The the DT cord-262892-n38r8n70 94 2 evidence evidence NN cord-262892-n38r8n70 94 3 base base NN cord-262892-n38r8n70 94 4 for for IN cord-262892-n38r8n70 94 5 the the DT cord-262892-n38r8n70 94 6 specific specific JJ cord-262892-n38r8n70 94 7 effect effect NN cord-262892-n38r8n70 94 8 of of IN cord-262892-n38r8n70 94 9 micronutrient micronutrient JJ cord-262892-n38r8n70 94 10 supplementation supplementation NN cord-262892-n38r8n70 94 11 in in IN cord-262892-n38r8n70 94 12 children child NNS cord-262892-n38r8n70 94 13 with with IN cord-262892-n38r8n70 94 14 HIV HIV NNP cord-262892-n38r8n70 94 15 is be VBZ cord-262892-n38r8n70 94 16 limited limit VBN cord-262892-n38r8n70 94 17 , , , cord-262892-n38r8n70 94 18 but but CC cord-262892-n38r8n70 94 19 a a DT cord-262892-n38r8n70 94 20 recent recent JJ cord-262892-n38r8n70 94 21 Cochrane Cochrane NNP cord-262892-n38r8n70 94 22 review review NN cord-262892-n38r8n70 94 23 of of IN cord-262892-n38r8n70 94 24 11 11 CD cord-262892-n38r8n70 94 25 studies study NNS cord-262892-n38r8n70 94 26 with with IN cord-262892-n38r8n70 94 27 2,412 2,412 CD cord-262892-n38r8n70 94 28 participants participant NNS cord-262892-n38r8n70 94 29 made make VBD cord-262892-n38r8n70 94 30 the the DT cord-262892-n38r8n70 94 31 following follow VBG cord-262892-n38r8n70 94 32 key key JJ cord-262892-n38r8n70 94 33 recommendations recommendation NNS cord-262892-n38r8n70 94 34 for for IN cord-262892-n38r8n70 94 35 practice practice NN cord-262892-n38r8n70 94 36 . . . cord-262892-n38r8n70 95 1 Benefits benefit NNS cord-262892-n38r8n70 95 2 of of IN cord-262892-n38r8n70 95 3 periodic periodic JJ cord-262892-n38r8n70 95 4 vitamin vitamin NN cord-262892-n38r8n70 95 5 A a DT cord-262892-n38r8n70 95 6 supplementation supplementation NN cord-262892-n38r8n70 95 7 in in IN cord-262892-n38r8n70 95 8 children child NNS cord-262892-n38r8n70 95 9 over over IN cord-262892-n38r8n70 95 10 6 6 CD cord-262892-n38r8n70 95 11 months month NNS cord-262892-n38r8n70 95 12 of of IN cord-262892-n38r8n70 95 13 age age NN cord-262892-n38r8n70 95 14 with with IN cord-262892-n38r8n70 95 15 HIV HIV NNP cord-262892-n38r8n70 95 16 infection infection NN cord-262892-n38r8n70 95 17 in in IN cord-262892-n38r8n70 95 18 resource resource NN cord-262892-n38r8n70 95 19 - - HYPH cord-262892-n38r8n70 95 20 limited limit VBN cord-262892-n38r8n70 95 21 settings setting NNS cord-262892-n38r8n70 95 22 were be VBD cord-262892-n38r8n70 95 23 supported support VBN cord-262892-n38r8n70 95 24 by by IN cord-262892-n38r8n70 95 25 data datum NNS cord-262892-n38r8n70 95 26 from from IN cord-262892-n38r8n70 95 27 three three CD cord-262892-n38r8n70 95 28 African african JJ cord-262892-n38r8n70 95 29 trials trial NNS cord-262892-n38r8n70 95 30 and and CC cord-262892-n38r8n70 95 31 were be VBD cord-262892-n38r8n70 95 32 consistent consistent JJ cord-262892-n38r8n70 95 33 with with IN cord-262892-n38r8n70 95 34 evidence evidence NN cord-262892-n38r8n70 95 35 of of IN cord-262892-n38r8n70 95 36 benefits benefit NNS cord-262892-n38r8n70 95 37 of of IN cord-262892-n38r8n70 95 38 supplementation supplementation NN cord-262892-n38r8n70 95 39 in in IN cord-262892-n38r8n70 95 40 uninfected uninfected JJ cord-262892-n38r8n70 95 41 children child NNS cord-262892-n38r8n70 95 42 . . . cord-262892-n38r8n70 96 1 Zinc zinc NN cord-262892-n38r8n70 96 2 supplements supplement NNS cord-262892-n38r8n70 96 3 reduced reduce VBD cord-262892-n38r8n70 96 4 diarrheal diarrheal JJ cord-262892-n38r8n70 96 5 morbidity morbidity NN cord-262892-n38r8n70 96 6 and and CC cord-262892-n38r8n70 96 7 had have VBD cord-262892-n38r8n70 96 8 no no DT cord-262892-n38r8n70 96 9 adverse adverse JJ cord-262892-n38r8n70 96 10 effects effect NNS cord-262892-n38r8n70 96 11 on on IN cord-262892-n38r8n70 96 12 disease disease NN cord-262892-n38r8n70 96 13 II II NNP cord-262892-n38r8n70 96 14 . . . cord-262892-n38r8n70 97 1 NUTRITION nutrition NN cord-262892-n38r8n70 97 2 AND and CC cord-262892-n38r8n70 97 3 LIFESTYLE lifestyle NN cord-262892-n38r8n70 97 4 progression progression NN cord-262892-n38r8n70 97 5 in in IN cord-262892-n38r8n70 97 6 a a DT cord-262892-n38r8n70 97 7 single single JJ cord-262892-n38r8n70 97 8 safety safety NN cord-262892-n38r8n70 97 9 trial trial NN cord-262892-n38r8n70 97 10 in in IN cord-262892-n38r8n70 97 11 South south JJ cord-262892-n38r8n70 97 12 African african JJ cord-262892-n38r8n70 97 13 children child NNS cord-262892-n38r8n70 97 14 . . . cord-262892-n38r8n70 98 1 Children child NNS cord-262892-n38r8n70 98 2 with with IN cord-262892-n38r8n70 98 3 HIV HIV NNP cord-262892-n38r8n70 98 4 should should MD cord-262892-n38r8n70 98 5 therefore therefore RB cord-262892-n38r8n70 98 6 receive receive VB cord-262892-n38r8n70 98 7 zinc zinc NN cord-262892-n38r8n70 98 8 supplements supplement NNS cord-262892-n38r8n70 98 9 in in IN cord-262892-n38r8n70 98 10 the the DT cord-262892-n38r8n70 98 11 management management NN cord-262892-n38r8n70 98 12 of of IN cord-262892-n38r8n70 98 13 diarrhea diarrhea NN cord-262892-n38r8n70 98 14 and and CC cord-262892-n38r8n70 98 15 severe severe JJ cord-262892-n38r8n70 98 16 acute acute JJ cord-262892-n38r8n70 98 17 malnutrition malnutrition NN cord-262892-n38r8n70 98 18 in in IN cord-262892-n38r8n70 98 19 the the DT cord-262892-n38r8n70 98 20 same same JJ cord-262892-n38r8n70 98 21 way way NN cord-262892-n38r8n70 98 22 as as IN cord-262892-n38r8n70 98 23 uninfected uninfected JJ cord-262892-n38r8n70 98 24 children child NNS cord-262892-n38r8n70 98 25 with with IN cord-262892-n38r8n70 98 26 the the DT cord-262892-n38r8n70 98 27 same same JJ cord-262892-n38r8n70 98 28 conditions condition NNS cord-262892-n38r8n70 98 29 . . . cord-262892-n38r8n70 99 1 The the DT cord-262892-n38r8n70 99 2 review review NN cord-262892-n38r8n70 99 3 emphasized emphasize VBD cord-262892-n38r8n70 99 4 that that IN cord-262892-n38r8n70 99 5 micronutrient micronutrient NN cord-262892-n38r8n70 99 6 deficiencies deficiency NNS cord-262892-n38r8n70 99 7 and and CC cord-262892-n38r8n70 99 8 immune immune JJ cord-262892-n38r8n70 99 9 dysfunction dysfunction NN cord-262892-n38r8n70 99 10 in in IN cord-262892-n38r8n70 99 11 children child NNS cord-262892-n38r8n70 99 12 with with IN cord-262892-n38r8n70 99 13 HIV HIV NNP cord-262892-n38r8n70 99 14 would would MD cord-262892-n38r8n70 99 15 only only RB cord-262892-n38r8n70 99 16 be be VB cord-262892-n38r8n70 99 17 restored restore VBN cord-262892-n38r8n70 99 18 with with IN cord-262892-n38r8n70 99 19 effective effective JJ cord-262892-n38r8n70 99 20 suppression suppression NN cord-262892-n38r8n70 99 21 of of IN cord-262892-n38r8n70 99 22 HIV HIV NNP cord-262892-n38r8n70 99 23 replication replication NN cord-262892-n38r8n70 99 24 [ [ -LRB- cord-262892-n38r8n70 99 25 30 30 CD cord-262892-n38r8n70 99 26 ] ] -RRB- cord-262892-n38r8n70 99 27 . . . cord-262892-n38r8n70 100 1 cART cART NNP cord-262892-n38r8n70 100 2 consists consist VBZ cord-262892-n38r8n70 100 3 of of IN cord-262892-n38r8n70 100 4 drugs drug NNS cord-262892-n38r8n70 100 5 that that WDT cord-262892-n38r8n70 100 6 target target VBP cord-262892-n38r8n70 100 7 the the DT cord-262892-n38r8n70 100 8 life life NN cord-262892-n38r8n70 100 9 cycle cycle NN cord-262892-n38r8n70 100 10 of of IN cord-262892-n38r8n70 100 11 HIV HIV NNP cord-262892-n38r8n70 100 12 at at IN cord-262892-n38r8n70 100 13 specific specific JJ cord-262892-n38r8n70 100 14 enzymes enzyme NNS cord-262892-n38r8n70 100 15 or or CC cord-262892-n38r8n70 100 16 receptors receptor NNS cord-262892-n38r8n70 100 17 to to TO cord-262892-n38r8n70 100 18 inhibit inhibit VB cord-262892-n38r8n70 100 19 replication replication NN cord-262892-n38r8n70 100 20 thereby thereby RB cord-262892-n38r8n70 100 21 preserving preserve VBG cord-262892-n38r8n70 100 22 or or CC cord-262892-n38r8n70 100 23 restoring restore VBG cord-262892-n38r8n70 100 24 immune immune JJ cord-262892-n38r8n70 100 25 function function NN cord-262892-n38r8n70 100 26 . . . cord-262892-n38r8n70 101 1 Specific specific JJ cord-262892-n38r8n70 101 2 goals goal NNS cord-262892-n38r8n70 101 3 of of IN cord-262892-n38r8n70 101 4 administration administration NN cord-262892-n38r8n70 101 5 of of IN cord-262892-n38r8n70 101 6 cART cART NNP cord-262892-n38r8n70 101 7 include include VBP cord-262892-n38r8n70 101 8 maximally maximally RB cord-262892-n38r8n70 101 9 reduction reduction NN cord-262892-n38r8n70 101 10 of of IN cord-262892-n38r8n70 101 11 the the DT cord-262892-n38r8n70 101 12 plasma plasma NN cord-262892-n38r8n70 101 13 viral viral JJ cord-262892-n38r8n70 101 14 load load NN cord-262892-n38r8n70 101 15 below below IN cord-262892-n38r8n70 101 16 the the DT cord-262892-n38r8n70 101 17 limit limit NN cord-262892-n38r8n70 101 18 of of IN cord-262892-n38r8n70 101 19 detection detection NN cord-262892-n38r8n70 101 20 ( ( -LRB- cord-262892-n38r8n70 101 21 < < NNP cord-262892-n38r8n70 101 22 50 50 CD cord-262892-n38r8n70 101 23 copies copy NNS cord-262892-n38r8n70 101 24 / / SYM cord-262892-n38r8n70 101 25 mL ml NN cord-262892-n38r8n70 101 26 ) ) -RRB- cord-262892-n38r8n70 101 27 , , , cord-262892-n38r8n70 101 28 prevention prevention NN cord-262892-n38r8n70 101 29 of of IN cord-262892-n38r8n70 101 30 a a DT cord-262892-n38r8n70 101 31 selection selection NN cord-262892-n38r8n70 101 32 of of IN cord-262892-n38r8n70 101 33 drug drug NN cord-262892-n38r8n70 101 34 - - HYPH cord-262892-n38r8n70 101 35 resistant resistant JJ cord-262892-n38r8n70 101 36 strains strain NNS cord-262892-n38r8n70 101 37 and and CC cord-262892-n38r8n70 101 38 maintenance maintenance NN cord-262892-n38r8n70 101 39 of of IN cord-262892-n38r8n70 101 40 good good JJ cord-262892-n38r8n70 101 41 immunologic immunologic JJ cord-262892-n38r8n70 101 42 status status NN cord-262892-n38r8n70 101 43 ( ( -LRB- cord-262892-n38r8n70 101 44 repopulation repopulation NN cord-262892-n38r8n70 101 45 with with IN cord-262892-n38r8n70 101 46 CD4 CD4 NNP cord-262892-n38r8n70 101 47 + + CC cord-262892-n38r8n70 101 48 -naïve -naïve NNP cord-262892-n38r8n70 101 49 T T NNP cord-262892-n38r8n70 101 50 cells cell NNS cord-262892-n38r8n70 101 51 ) ) -RRB- cord-262892-n38r8n70 101 52 , , , cord-262892-n38r8n70 101 53 and and CC cord-262892-n38r8n70 101 54 prevention prevention NN cord-262892-n38r8n70 101 55 of of IN cord-262892-n38r8n70 101 56 clinical clinical JJ cord-262892-n38r8n70 101 57 disease disease NN cord-262892-n38r8n70 101 58 progression progression NN cord-262892-n38r8n70 101 59 and and CC cord-262892-n38r8n70 101 60 OIs ois NN cord-262892-n38r8n70 101 61 . . . cord-262892-n38r8n70 102 1 Clinical clinical JJ cord-262892-n38r8n70 102 2 trials trial NNS cord-262892-n38r8n70 102 3 of of IN cord-262892-n38r8n70 102 4 cART cART VBN cord-262892-n38r8n70 102 5 in in IN cord-262892-n38r8n70 102 6 infants infant NNS cord-262892-n38r8n70 102 7 and and CC cord-262892-n38r8n70 102 8 children child NNS cord-262892-n38r8n70 102 9 with with IN cord-262892-n38r8n70 102 10 HIV HIV NNP cord-262892-n38r8n70 102 11 have have VBP cord-262892-n38r8n70 102 12 demonstrated demonstrate VBN cord-262892-n38r8n70 102 13 dramatic dramatic JJ cord-262892-n38r8n70 102 14 reductions reduction NNS cord-262892-n38r8n70 102 15 in in IN cord-262892-n38r8n70 102 16 morbidity morbidity NN cord-262892-n38r8n70 102 17 and and CC cord-262892-n38r8n70 102 18 mortality mortality NN cord-262892-n38r8n70 102 19 ( ( -LRB- cord-262892-n38r8n70 102 20 > > NFP cord-262892-n38r8n70 102 21 80 80 CD cord-262892-n38r8n70 102 22 - - SYM cord-262892-n38r8n70 102 23 90 90 CD cord-262892-n38r8n70 102 24 % % NN cord-262892-n38r8n70 102 25 ) ) -RRB- cord-262892-n38r8n70 102 26 in in IN cord-262892-n38r8n70 102 27 the the DT cord-262892-n38r8n70 102 28 United United NNP cord-262892-n38r8n70 102 29 States States NNP cord-262892-n38r8n70 102 30 since since IN cord-262892-n38r8n70 102 31 widespread widespread JJ cord-262892-n38r8n70 102 32 implementation implementation NN cord-262892-n38r8n70 102 33 from from IN cord-262892-n38r8n70 102 34 1996 1996 CD cord-262892-n38r8n70 102 35 onward onward RB cord-262892-n38r8n70 102 36 , , , cord-262892-n38r8n70 102 37 so so CC cord-262892-n38r8n70 102 38 the the DT cord-262892-n38r8n70 102 39 vast vast JJ cord-262892-n38r8n70 102 40 majority majority NN cord-262892-n38r8n70 102 41 of of IN cord-262892-n38r8n70 102 42 infants infant NNS cord-262892-n38r8n70 102 43 and and CC cord-262892-n38r8n70 102 44 children child NNS cord-262892-n38r8n70 102 45 with with IN cord-262892-n38r8n70 102 46 HIV-1 HIV-1 NNP cord-262892-n38r8n70 102 47 can can MD cord-262892-n38r8n70 102 48 now now RB cord-262892-n38r8n70 102 49 be be VB cord-262892-n38r8n70 102 50 expected expect VBN cord-262892-n38r8n70 102 51 to to TO cord-262892-n38r8n70 102 52 survive survive VB cord-262892-n38r8n70 102 53 to to IN cord-262892-n38r8n70 102 54 adulthood adulthood NN cord-262892-n38r8n70 102 55 [ [ -LRB- cord-262892-n38r8n70 102 56 31 31 CD cord-262892-n38r8n70 102 57 , , , cord-262892-n38r8n70 102 58 32 32 CD cord-262892-n38r8n70 102 59 ] ] -RRB- cord-262892-n38r8n70 102 60 . . . cord-262892-n38r8n70 103 1 Five five CD cord-262892-n38r8n70 103 2 classes class NNS cord-262892-n38r8n70 103 3 of of IN cord-262892-n38r8n70 103 4 ARV ARV NNP cord-262892-n38r8n70 103 5 drugs drug NNS cord-262892-n38r8n70 103 6 are be VBP cord-262892-n38r8n70 103 7 commonly commonly RB cord-262892-n38r8n70 103 8 available available JJ cord-262892-n38r8n70 103 9 for for IN cord-262892-n38r8n70 103 10 HIV HIV NNP cord-262892-n38r8n70 103 11 therapy therapy NN cord-262892-n38r8n70 103 12 . . . cord-262892-n38r8n70 104 1 Two two CD cord-262892-n38r8n70 104 2 classes class NNS cord-262892-n38r8n70 104 3 target target VBP cord-262892-n38r8n70 104 4 the the DT cord-262892-n38r8n70 104 5 enzyme enzyme NN cord-262892-n38r8n70 104 6 reverse reverse NN cord-262892-n38r8n70 105 1 transcriptase transcriptase JJ cord-262892-n38r8n70 105 2 - - HYPH cord-262892-n38r8n70 105 3 non non JJ cord-262892-n38r8n70 105 4 - - JJ cord-262892-n38r8n70 105 5 nucleoside nucleoside JJ cord-262892-n38r8n70 105 6 reverse reverse JJ cord-262892-n38r8n70 105 7 transcriptase transcriptase NN cord-262892-n38r8n70 105 8 inhibitors inhibitor NNS cord-262892-n38r8n70 105 9 ( ( -LRB- cord-262892-n38r8n70 105 10 NRTIs NRTIs NNP cord-262892-n38r8n70 105 11 ) ) -RRB- cord-262892-n38r8n70 105 12 and and CC cord-262892-n38r8n70 105 13 the the DT cord-262892-n38r8n70 105 14 non non NNS cord-262892-n38r8n70 105 15 - - NN cord-262892-n38r8n70 105 16 NRTIs NRTIs NNPS cord-262892-n38r8n70 105 17 . . . cord-262892-n38r8n70 106 1 A a DT cord-262892-n38r8n70 106 2 third third JJ cord-262892-n38r8n70 106 3 class class NN cord-262892-n38r8n70 106 4 - - HYPH cord-262892-n38r8n70 106 5 protease protease NN cord-262892-n38r8n70 106 6 inhibitors inhibitor NNS cord-262892-n38r8n70 106 7 ( ( -LRB- cord-262892-n38r8n70 106 8 PIs)-target pis)-target VB cord-262892-n38r8n70 106 9 viral viral JJ cord-262892-n38r8n70 106 10 protease protease NN cord-262892-n38r8n70 106 11 , , , cord-262892-n38r8n70 106 12 whereas whereas IN cord-262892-n38r8n70 106 13 integrase integrase NNP cord-262892-n38r8n70 106 14 inhibitors inhibitor NNS cord-262892-n38r8n70 106 15 target target VBP cord-262892-n38r8n70 106 16 that that IN cord-262892-n38r8n70 106 17 corresponding corresponding JJ cord-262892-n38r8n70 106 18 enzyme enzyme NN cord-262892-n38r8n70 106 19 . . . cord-262892-n38r8n70 107 1 In in IN cord-262892-n38r8n70 107 2 addition addition NN cord-262892-n38r8n70 107 3 , , , cord-262892-n38r8n70 107 4 CCR5 CCR5 NNP cord-262892-n38r8n70 107 5 inhibitors inhibitor NNS cord-262892-n38r8n70 107 6 target target VBP cord-262892-n38r8n70 107 7 the the DT cord-262892-n38r8n70 107 8 viral viral JJ cord-262892-n38r8n70 107 9 co co NN cord-262892-n38r8n70 107 10 - - NN cord-262892-n38r8n70 107 11 receptor receptor NN cord-262892-n38r8n70 107 12 CCR5 CCR5 NNP cord-262892-n38r8n70 107 13 on on IN cord-262892-n38r8n70 107 14 permissive permissive JJ cord-262892-n38r8n70 107 15 target target NN cord-262892-n38r8n70 107 16 cells cell NNS cord-262892-n38r8n70 107 17 . . . cord-262892-n38r8n70 108 1 HIV-1 HIV-1 NNP cord-262892-n38r8n70 108 2 mutability mutability NN cord-262892-n38r8n70 108 3 is be VBZ cord-262892-n38r8n70 108 4 largely largely RB cord-262892-n38r8n70 108 5 the the DT cord-262892-n38r8n70 108 6 result result NN cord-262892-n38r8n70 108 7 of of IN cord-262892-n38r8n70 108 8 errors error NNS cord-262892-n38r8n70 108 9 introduced introduce VBN cord-262892-n38r8n70 108 10 into into IN cord-262892-n38r8n70 108 11 the the DT cord-262892-n38r8n70 108 12 viral viral JJ cord-262892-n38r8n70 108 13 genome genome NN cord-262892-n38r8n70 108 14 during during IN cord-262892-n38r8n70 108 15 replication replication NN cord-262892-n38r8n70 108 16 . . . cord-262892-n38r8n70 109 1 The the DT cord-262892-n38r8n70 109 2 HIV HIV NNP cord-262892-n38r8n70 109 3 genome genome NN cord-262892-n38r8n70 109 4 is be VBZ cord-262892-n38r8n70 109 5 approximately approximately RB cord-262892-n38r8n70 109 6 10,000 10,000 CD cord-262892-n38r8n70 109 7 nucleotides nucleotide NNS cord-262892-n38r8n70 109 8 long long JJ cord-262892-n38r8n70 109 9 , , , cord-262892-n38r8n70 109 10 and and CC cord-262892-n38r8n70 109 11 each each DT cord-262892-n38r8n70 109 12 new new JJ cord-262892-n38r8n70 109 13 virion virion NN cord-262892-n38r8n70 109 14 has have VBZ cord-262892-n38r8n70 109 15 an an DT cord-262892-n38r8n70 109 16 average average NN cord-262892-n38r8n70 109 17 of of IN cord-262892-n38r8n70 109 18 one one CD cord-262892-n38r8n70 109 19 mutation mutation NN cord-262892-n38r8n70 109 20 . . . cord-262892-n38r8n70 110 1 This this DT cord-262892-n38r8n70 110 2 results result VBZ cord-262892-n38r8n70 110 3 in in IN cord-262892-n38r8n70 110 4 a a DT cord-262892-n38r8n70 110 5 large large JJ cord-262892-n38r8n70 110 6 pool pool NN cord-262892-n38r8n70 110 7 of of IN cord-262892-n38r8n70 110 8 quasi quasi JJ cord-262892-n38r8n70 110 9 - - NNS cord-262892-n38r8n70 110 10 species specie NNS cord-262892-n38r8n70 110 11 of of IN cord-262892-n38r8n70 110 12 viral viral JJ cord-262892-n38r8n70 110 13 variants variant NNS cord-262892-n38r8n70 110 14 that that WDT cord-262892-n38r8n70 110 15 are be VBP cord-262892-n38r8n70 110 16 incapable incapable JJ cord-262892-n38r8n70 110 17 of of IN cord-262892-n38r8n70 110 18 productive productive JJ cord-262892-n38r8n70 110 19 infection infection NN cord-262892-n38r8n70 110 20 but but CC cord-262892-n38r8n70 110 21 some some DT cord-262892-n38r8n70 110 22 of of IN cord-262892-n38r8n70 110 23 which which WDT cord-262892-n38r8n70 110 24 may may MD cord-262892-n38r8n70 110 25 provide provide VB cord-262892-n38r8n70 110 26 an an DT cord-262892-n38r8n70 110 27 adaptive adaptive JJ cord-262892-n38r8n70 110 28 benefit benefit NN cord-262892-n38r8n70 110 29 , , , cord-262892-n38r8n70 110 30 for for IN cord-262892-n38r8n70 110 31 example example NN cord-262892-n38r8n70 110 32 , , , cord-262892-n38r8n70 110 33 the the DT cord-262892-n38r8n70 110 34 development development NN cord-262892-n38r8n70 110 35 of of IN cord-262892-n38r8n70 110 36 ART art NN cord-262892-n38r8n70 110 37 resistance resistance NN cord-262892-n38r8n70 110 38 , , , cord-262892-n38r8n70 110 39 to to IN cord-262892-n38r8n70 110 40 the the DT cord-262892-n38r8n70 110 41 virion virion NN cord-262892-n38r8n70 110 42 . . . cord-262892-n38r8n70 111 1 Drug drug NN cord-262892-n38r8n70 111 2 - - HYPH cord-262892-n38r8n70 111 3 resistance resistance NN cord-262892-n38r8n70 111 4 of of IN cord-262892-n38r8n70 111 5 the the DT cord-262892-n38r8n70 111 6 virus virus NN cord-262892-n38r8n70 111 7 can can MD cord-262892-n38r8n70 111 8 develop develop VB cord-262892-n38r8n70 111 9 during during IN cord-262892-n38r8n70 111 10 cART cART NNP cord-262892-n38r8n70 111 11 administration administration NN cord-262892-n38r8n70 111 12 because because IN cord-262892-n38r8n70 111 13 of of IN cord-262892-n38r8n70 111 14 poor poor JJ cord-262892-n38r8n70 111 15 adherence adherence NN cord-262892-n38r8n70 111 16 , , , cord-262892-n38r8n70 111 17 a a DT cord-262892-n38r8n70 111 18 regimen regimen NN cord-262892-n38r8n70 111 19 that that WDT cord-262892-n38r8n70 111 20 is be VBZ cord-262892-n38r8n70 111 21 not not RB cord-262892-n38r8n70 111 22 potent potent JJ cord-262892-n38r8n70 111 23 , , , cord-262892-n38r8n70 111 24 or or CC cord-262892-n38r8n70 111 25 a a DT cord-262892-n38r8n70 111 26 combination combination NN cord-262892-n38r8n70 111 27 II ii NN cord-262892-n38r8n70 111 28 . . . cord-262892-n38r8n70 112 1 NUTRITION nutrition NN cord-262892-n38r8n70 112 2 AND and CC cord-262892-n38r8n70 112 3 LIFESTYLE lifestyle NN cord-262892-n38r8n70 112 4 of of IN cord-262892-n38r8n70 112 5 these these DT cord-262892-n38r8n70 112 6 factors factor NNS cord-262892-n38r8n70 112 7 resulting result VBG cord-262892-n38r8n70 112 8 in in IN cord-262892-n38r8n70 112 9 incomplete incomplete JJ cord-262892-n38r8n70 112 10 virologic virologic JJ cord-262892-n38r8n70 112 11 suppression suppression NN cord-262892-n38r8n70 112 12 . . . cord-262892-n38r8n70 113 1 In in IN cord-262892-n38r8n70 113 2 addition addition NN cord-262892-n38r8n70 113 3 , , , cord-262892-n38r8n70 113 4 primary primary JJ cord-262892-n38r8n70 113 5 drug drug NN cord-262892-n38r8n70 113 6 resistance resistance NN cord-262892-n38r8n70 113 7 may may MD cord-262892-n38r8n70 113 8 occur occur VB cord-262892-n38r8n70 113 9 in in IN cord-262892-n38r8n70 113 10 ARV ARV NNP cord-262892-n38r8n70 113 11 - - HYPH cord-262892-n38r8n70 113 12 naive naive JJ cord-262892-n38r8n70 113 13 infants infant NNS cord-262892-n38r8n70 113 14 and and CC cord-262892-n38r8n70 113 15 children child NNS cord-262892-n38r8n70 113 16 who who WP cord-262892-n38r8n70 113 17 can can MD cord-262892-n38r8n70 113 18 become become VB cord-262892-n38r8n70 113 19 infected infect VBN cord-262892-n38r8n70 113 20 with with IN cord-262892-n38r8n70 113 21 the the DT cord-262892-n38r8n70 113 22 resistant resistant JJ cord-262892-n38r8n70 113 23 virus virus NN cord-262892-n38r8n70 113 24 . . . cord-262892-n38r8n70 114 1 Aggressive aggressive JJ cord-262892-n38r8n70 114 2 , , , cord-262892-n38r8n70 114 3 multidrug multidrug NN cord-262892-n38r8n70 114 4 cART cART VBN cord-262892-n38r8n70 114 5 as as RB cord-262892-n38r8n70 114 6 early early RB cord-262892-n38r8n70 114 7 in in IN cord-262892-n38r8n70 114 8 infection infection NN cord-262892-n38r8n70 114 9 as as IN cord-262892-n38r8n70 114 10 possible possible JJ cord-262892-n38r8n70 114 11 , , , cord-262892-n38r8n70 114 12 with with IN cord-262892-n38r8n70 114 13 daily daily JJ cord-262892-n38r8n70 114 14 adherence adherence NN cord-262892-n38r8n70 114 15 for for IN cord-262892-n38r8n70 114 16 an an DT cord-262892-n38r8n70 114 17 indefinite indefinite JJ cord-262892-n38r8n70 114 18 period period NN cord-262892-n38r8n70 114 19 , , , cord-262892-n38r8n70 114 20 is be VBZ cord-262892-n38r8n70 114 21 advocated advocate VBN cord-262892-n38r8n70 114 22 to to TO cord-262892-n38r8n70 114 23 fully fully RB cord-262892-n38r8n70 114 24 suppress suppress VB cord-262892-n38r8n70 114 25 viral viral JJ cord-262892-n38r8n70 114 26 replication replication NN cord-262892-n38r8n70 114 27 and and CC cord-262892-n38r8n70 114 28 to to TO cord-262892-n38r8n70 114 29 preclude preclude VB cord-262892-n38r8n70 114 30 the the DT cord-262892-n38r8n70 114 31 selection selection NN cord-262892-n38r8n70 114 32 or or CC cord-262892-n38r8n70 114 33 emergence emergence NN cord-262892-n38r8n70 114 34 of of IN cord-262892-n38r8n70 114 35 resistant resistant JJ cord-262892-n38r8n70 114 36 viral viral JJ cord-262892-n38r8n70 114 37 variants variant NNS cord-262892-n38r8n70 114 38 . . . cord-262892-n38r8n70 115 1 Resistance resistance NN cord-262892-n38r8n70 115 2 testing testing NN cord-262892-n38r8n70 115 3 has have VBZ cord-262892-n38r8n70 115 4 enhanced enhance VBN cord-262892-n38r8n70 115 5 the the DT cord-262892-n38r8n70 115 6 ability ability NN cord-262892-n38r8n70 115 7 to to TO cord-262892-n38r8n70 115 8 choose choose VB cord-262892-n38r8n70 115 9 effective effective JJ cord-262892-n38r8n70 115 10 initial initial JJ cord-262892-n38r8n70 115 11 regimens regimen NNS cord-262892-n38r8n70 115 12 as as RB cord-262892-n38r8n70 115 13 well well RB cord-262892-n38r8n70 115 14 as as IN cord-262892-n38r8n70 115 15 second second JJ cord-262892-n38r8n70 115 16 - - HYPH cord-262892-n38r8n70 115 17 or or CC cord-262892-n38r8n70 115 18 third third JJ cord-262892-n38r8n70 115 19 - - HYPH cord-262892-n38r8n70 115 20 line line NN cord-262892-n38r8n70 115 21 regimens regimen NNS cord-262892-n38r8n70 115 22 . . . cord-262892-n38r8n70 116 1 Therapeutic therapeutic JJ cord-262892-n38r8n70 116 2 strategies strategy NNS cord-262892-n38r8n70 116 3 continue continue VBP cord-262892-n38r8n70 116 4 to to TO cord-262892-n38r8n70 116 5 focus focus VB cord-262892-n38r8n70 116 6 on on IN cord-262892-n38r8n70 116 7 timely timely JJ cord-262892-n38r8n70 116 8 initiation initiation NN cord-262892-n38r8n70 116 9 of of IN cord-262892-n38r8n70 116 10 ARV ARV NNP cord-262892-n38r8n70 116 11 regimens regimen NNS cord-262892-n38r8n70 116 12 that that WDT cord-262892-n38r8n70 116 13 are be VBP cord-262892-n38r8n70 116 14 capable capable JJ cord-262892-n38r8n70 116 15 of of IN cord-262892-n38r8n70 116 16 maximally maximally RB cord-262892-n38r8n70 116 17 suppressing suppress VBG cord-262892-n38r8n70 116 18 viral viral JJ cord-262892-n38r8n70 116 19 replication replication NN cord-262892-n38r8n70 116 20 in in IN cord-262892-n38r8n70 116 21 order order NN cord-262892-n38r8n70 116 22 to to TO cord-262892-n38r8n70 116 23 prevent prevent VB cord-262892-n38r8n70 116 24 disease disease NN cord-262892-n38r8n70 116 25 progression progression NN cord-262892-n38r8n70 116 26 , , , cord-262892-n38r8n70 116 27 preserve preserve VB cord-262892-n38r8n70 116 28 or or CC cord-262892-n38r8n70 116 29 restore restore VB cord-262892-n38r8n70 116 30 quantitative quantitative JJ cord-262892-n38r8n70 116 31 and and CC cord-262892-n38r8n70 116 32 qualitative qualitative JJ cord-262892-n38r8n70 116 33 immunologic immunologic JJ cord-262892-n38r8n70 116 34 function function NN cord-262892-n38r8n70 116 35 , , , cord-262892-n38r8n70 116 36 and and CC cord-262892-n38r8n70 116 37 reduce reduce VB cord-262892-n38r8n70 116 38 the the DT cord-262892-n38r8n70 116 39 development development NN cord-262892-n38r8n70 116 40 of of IN cord-262892-n38r8n70 116 41 drug drug NN cord-262892-n38r8n70 116 42 resistance resistance NN cord-262892-n38r8n70 116 43 [ [ -LRB- cord-262892-n38r8n70 116 44 33 33 CD cord-262892-n38r8n70 116 45 ] ] -RRB- cord-262892-n38r8n70 116 46 . . . cord-262892-n38r8n70 117 1 Difficulties difficulty NNS cord-262892-n38r8n70 117 2 with with IN cord-262892-n38r8n70 117 3 long long JJ cord-262892-n38r8n70 117 4 - - HYPH cord-262892-n38r8n70 117 5 term term NN cord-262892-n38r8n70 117 6 adherence adherence NN cord-262892-n38r8n70 117 7 to to IN cord-262892-n38r8n70 117 8 cART cART VBN cord-262892-n38r8n70 117 9 - - : cord-262892-n38r8n70 117 10 particularly particularly RB cord-262892-n38r8n70 117 11 in in IN cord-262892-n38r8n70 117 12 infants infant NNS cord-262892-n38r8n70 117 13 and and CC cord-262892-n38r8n70 117 14 children child NNS cord-262892-n38r8n70 117 15 because because IN cord-262892-n38r8n70 117 16 of of IN cord-262892-n38r8n70 117 17 variable variable JJ cord-262892-n38r8n70 117 18 drug drug NN cord-262892-n38r8n70 117 19 administration administration NN cord-262892-n38r8n70 117 20 , , , cord-262892-n38r8n70 117 21 absorption absorption NN cord-262892-n38r8n70 117 22 , , , cord-262892-n38r8n70 117 23 and and CC cord-262892-n38r8n70 117 24 metabolism metabolism NN cord-262892-n38r8n70 117 25 ; ; : cord-262892-n38r8n70 117 26 pretreatment pretreatment NN cord-262892-n38r8n70 117 27 with with IN cord-262892-n38r8n70 117 28 maternal maternal JJ cord-262892-n38r8n70 117 29 cART cart JJ cord-262892-n38r8n70 117 30 and and CC cord-262892-n38r8n70 117 31 vertical vertical JJ cord-262892-n38r8n70 117 32 transmission transmission NN cord-262892-n38r8n70 117 33 of of IN cord-262892-n38r8n70 117 34 drug drug NN cord-262892-n38r8n70 117 35 - - HYPH cord-262892-n38r8n70 117 36 resistant resistant JJ cord-262892-n38r8n70 117 37 virus virus NN cord-262892-n38r8n70 117 38 ; ; : cord-262892-n38r8n70 117 39 acceptability acceptability NN cord-262892-n38r8n70 117 40 and and CC cord-262892-n38r8n70 117 41 palatability palatability NN cord-262892-n38r8n70 117 42 of of IN cord-262892-n38r8n70 117 43 medications medication NNS cord-262892-n38r8n70 117 44 ; ; : cord-262892-n38r8n70 117 45 and and CC cord-262892-n38r8n70 117 46 refrigeration refrigeration NN cord-262892-n38r8n70 117 47 of of IN cord-262892-n38r8n70 117 48 syrup syrup NN cord-262892-n38r8n70 117 49 formulations formulation NNS cord-262892-n38r8n70 117 50 in in IN cord-262892-n38r8n70 117 51 warm warm JJ cord-262892-n38r8n70 117 52 climates climate NNS cord-262892-n38r8n70 117 53 - - , cord-262892-n38r8n70 117 54 are be VBP cord-262892-n38r8n70 117 55 all all RB cord-262892-n38r8n70 117 56 well well RB cord-262892-n38r8n70 117 57 documented document VBN cord-262892-n38r8n70 117 58 . . . cord-262892-n38r8n70 118 1 Long long JJ cord-262892-n38r8n70 118 2 - - HYPH cord-262892-n38r8n70 118 3 term term NN cord-262892-n38r8n70 118 4 follow follow NN cord-262892-n38r8n70 118 5 - - HYPH cord-262892-n38r8n70 118 6 up up NN cord-262892-n38r8n70 118 7 of of IN cord-262892-n38r8n70 118 8 infected infected JJ cord-262892-n38r8n70 118 9 infants infant NNS cord-262892-n38r8n70 118 10 and and CC cord-262892-n38r8n70 118 11 children child NNS cord-262892-n38r8n70 118 12 involves involve VBZ cord-262892-n38r8n70 118 13 longitudinal longitudinal JJ cord-262892-n38r8n70 118 14 determinations determination NNS cord-262892-n38r8n70 118 15 of of IN cord-262892-n38r8n70 118 16 prognostic prognostic JJ cord-262892-n38r8n70 118 17 markers marker NNS cord-262892-n38r8n70 118 18 , , , cord-262892-n38r8n70 118 19 including include VBG cord-262892-n38r8n70 118 20 number number NN cord-262892-n38r8n70 118 21 and and CC cord-262892-n38r8n70 118 22 percentage percentage NN cord-262892-n38r8n70 118 23 of of IN cord-262892-n38r8n70 118 24 CD4 CD4 NNP cord-262892-n38r8n70 118 25 T T NNP cord-262892-n38r8n70 118 26 cells cell NNS cord-262892-n38r8n70 118 27 , , , cord-262892-n38r8n70 118 28 and and CC cord-262892-n38r8n70 118 29 viral viral JJ cord-262892-n38r8n70 118 30 load load NN cord-262892-n38r8n70 118 31 [ [ -LRB- cord-262892-n38r8n70 118 32 34 34 CD cord-262892-n38r8n70 118 33 ] ] -RRB- cord-262892-n38r8n70 118 34 . . . cord-262892-n38r8n70 119 1 Such such JJ cord-262892-n38r8n70 119 2 parameters parameter NNS cord-262892-n38r8n70 119 3 provide provide VBP cord-262892-n38r8n70 119 4 a a DT cord-262892-n38r8n70 119 5 useful useful JJ cord-262892-n38r8n70 119 6 framework framework NN cord-262892-n38r8n70 119 7 for for IN cord-262892-n38r8n70 119 8 the the DT cord-262892-n38r8n70 119 9 time time NN cord-262892-n38r8n70 119 10 to to TO cord-262892-n38r8n70 119 11 initiate initiate VB cord-262892-n38r8n70 119 12 and and CC cord-262892-n38r8n70 119 13 change change VB cord-262892-n38r8n70 119 14 therapy therapy NN cord-262892-n38r8n70 119 15 but but CC cord-262892-n38r8n70 119 16 involve involve VBP cord-262892-n38r8n70 119 17 frequent frequent JJ cord-262892-n38r8n70 119 18 venipuncture venipuncture NN cord-262892-n38r8n70 119 19 in in IN cord-262892-n38r8n70 119 20 minors minor NNS cord-262892-n38r8n70 119 21 . . . cord-262892-n38r8n70 120 1 Long long JJ cord-262892-n38r8n70 120 2 - - HYPH cord-262892-n38r8n70 120 3 term term NN cord-262892-n38r8n70 120 4 toxicities toxicity NNS cord-262892-n38r8n70 120 5 include include VBP cord-262892-n38r8n70 120 6 lipodystrophy lipodystrophy NN cord-262892-n38r8n70 120 7 syndrome syndrome NN cord-262892-n38r8n70 120 8 [ [ -LRB- cord-262892-n38r8n70 120 9 35 35 CD cord-262892-n38r8n70 120 10 ] ] -RRB- cord-262892-n38r8n70 120 11 and and CC cord-262892-n38r8n70 120 12 lipid lipid NN cord-262892-n38r8n70 120 13 abnormalities abnormality NNS cord-262892-n38r8n70 120 14 , , , cord-262892-n38r8n70 120 15 cardiomyopathy cardiomyopathy NN cord-262892-n38r8n70 120 16 , , , cord-262892-n38r8n70 120 17 mitochondrial mitochondrial JJ cord-262892-n38r8n70 120 18 toxicity toxicity NN cord-262892-n38r8n70 120 19 and and CC cord-262892-n38r8n70 120 20 lactic lactic JJ cord-262892-n38r8n70 120 21 acidosis acidosis NN cord-262892-n38r8n70 120 22 , , , cord-262892-n38r8n70 120 23 renal renal JJ cord-262892-n38r8n70 120 24 tubular tubular JJ cord-262892-n38r8n70 120 25 acidosis acidosis NN cord-262892-n38r8n70 120 26 [ [ -LRB- cord-262892-n38r8n70 120 27 36 36 CD cord-262892-n38r8n70 120 28 ] ] -RRB- cord-262892-n38r8n70 120 29 , , , cord-262892-n38r8n70 120 30 hypersensitivity hypersensitivity NN cord-262892-n38r8n70 120 31 reactions reaction NNS cord-262892-n38r8n70 120 32 , , , cord-262892-n38r8n70 120 33 and and CC cord-262892-n38r8n70 120 34 CNS CNS NNP cord-262892-n38r8n70 120 35 toxicity toxicity NN cord-262892-n38r8n70 120 36 . . . cord-262892-n38r8n70 121 1 Fortunately fortunately RB cord-262892-n38r8n70 121 2 , , , cord-262892-n38r8n70 121 3 the the DT cord-262892-n38r8n70 121 4 availability availability NN cord-262892-n38r8n70 121 5 of of IN cord-262892-n38r8n70 121 6 new new JJ cord-262892-n38r8n70 121 7 drugs drug NNS cord-262892-n38r8n70 121 8 and and CC cord-262892-n38r8n70 121 9 drug drug NN cord-262892-n38r8n70 121 10 formulations formulation NNS cord-262892-n38r8n70 121 11 has have VBZ cord-262892-n38r8n70 121 12 led lead VBN cord-262892-n38r8n70 121 13 to to IN cord-262892-n38r8n70 121 14 the the DT cord-262892-n38r8n70 121 15 use use NN cord-262892-n38r8n70 121 16 of of IN cord-262892-n38r8n70 121 17 more more RBR cord-262892-n38r8n70 121 18 potent potent JJ cord-262892-n38r8n70 121 19 regimens regimen NNS cord-262892-n38r8n70 121 20 with with IN cord-262892-n38r8n70 121 21 reduced reduce VBN cord-262892-n38r8n70 121 22 short short JJ cord-262892-n38r8n70 121 23 - - HYPH cord-262892-n38r8n70 121 24 term term NN cord-262892-n38r8n70 121 25 toxicity toxicity NN cord-262892-n38r8n70 121 26 , , , cord-262892-n38r8n70 121 27 lower low JJR cord-262892-n38r8n70 121 28 pill pill NN cord-262892-n38r8n70 121 29 burden burden NN cord-262892-n38r8n70 121 30 , , , cord-262892-n38r8n70 121 31 and and CC cord-262892-n38r8n70 121 32 less less RBR cord-262892-n38r8n70 121 33 frequent frequent JJ cord-262892-n38r8n70 121 34 medication medication NN cord-262892-n38r8n70 121 35 administration administration NN cord-262892-n38r8n70 121 36 , , , cord-262892-n38r8n70 121 37 all all DT cord-262892-n38r8n70 121 38 factors factor NNS cord-262892-n38r8n70 121 39 that that WDT cord-262892-n38r8n70 121 40 are be VBP cord-262892-n38r8n70 121 41 associated associate VBN cord-262892-n38r8n70 121 42 with with IN cord-262892-n38r8n70 121 43 better well JJR cord-262892-n38r8n70 121 44 adherence adherence NN cord-262892-n38r8n70 121 45 and and CC cord-262892-n38r8n70 121 46 outcomes outcome NNS cord-262892-n38r8n70 121 47 . . . cord-262892-n38r8n70 122 1 Enteral enteral NN cord-262892-n38r8n70 122 2 [ [ -LRB- cord-262892-n38r8n70 122 3 37 37 CD cord-262892-n38r8n70 122 4 , , , cord-262892-n38r8n70 122 5 38 38 CD cord-262892-n38r8n70 122 6 ] ] -RRB- cord-262892-n38r8n70 122 7 or or CC cord-262892-n38r8n70 122 8 parenteral parenteral JJ cord-262892-n38r8n70 122 9 supplementation supplementation NN cord-262892-n38r8n70 122 10 and and CC cord-262892-n38r8n70 122 11 appetite appetite NN cord-262892-n38r8n70 122 12 stimulants stimulant NNS cord-262892-n38r8n70 122 13 [ [ -LRB- cord-262892-n38r8n70 122 14 39 39 CD cord-262892-n38r8n70 122 15 ] ] -RRB- cord-262892-n38r8n70 122 16 can can MD cord-262892-n38r8n70 122 17 improve improve VB cord-262892-n38r8n70 122 18 the the DT cord-262892-n38r8n70 122 19 nutritional nutritional JJ cord-262892-n38r8n70 122 20 status status NN cord-262892-n38r8n70 122 21 and and CC cord-262892-n38r8n70 122 22 weight weight NN cord-262892-n38r8n70 122 23 in in IN cord-262892-n38r8n70 122 24 children child NNS cord-262892-n38r8n70 122 25 with with IN cord-262892-n38r8n70 122 26 untreated untreated JJ cord-262892-n38r8n70 122 27 HIV HIV NNP cord-262892-n38r8n70 122 28 infection infection NN cord-262892-n38r8n70 122 29 but but CC cord-262892-n38r8n70 122 30 have have VBP cord-262892-n38r8n70 122 31 little little JJ cord-262892-n38r8n70 122 32 effect effect NN cord-262892-n38r8n70 122 33 on on IN cord-262892-n38r8n70 122 34 the the DT cord-262892-n38r8n70 122 35 growth growth NN cord-262892-n38r8n70 122 36 velocity velocity NN cord-262892-n38r8n70 122 37 of of IN cord-262892-n38r8n70 122 38 height height NN cord-262892-n38r8n70 122 39 . . . cord-262892-n38r8n70 123 1 However however RB cord-262892-n38r8n70 123 2 , , , cord-262892-n38r8n70 123 3 effective effective JJ cord-262892-n38r8n70 123 4 virologic virologic JJ cord-262892-n38r8n70 123 5 suppression suppression NN cord-262892-n38r8n70 123 6 with with IN cord-262892-n38r8n70 123 7 cART cART NNP cord-262892-n38r8n70 123 8 was be VBD cord-262892-n38r8n70 123 9 shown show VBN cord-262892-n38r8n70 123 10 to to TO cord-262892-n38r8n70 123 11 improve improve VB cord-262892-n38r8n70 123 12 mean mean JJ cord-262892-n38r8n70 123 13 weight weight NN cord-262892-n38r8n70 123 14 , , , cord-262892-n38r8n70 123 15 weight weight NN cord-262892-n38r8n70 123 16 for for IN cord-262892-n38r8n70 123 17 height height NN cord-262892-n38r8n70 123 18 , , , cord-262892-n38r8n70 123 19 and and CC cord-262892-n38r8n70 123 20 muscle muscle NN cord-262892-n38r8n70 123 21 mass mass NN cord-262892-n38r8n70 123 22 in in IN cord-262892-n38r8n70 123 23 67 67 CD cord-262892-n38r8n70 123 24 children child NNS cord-262892-n38r8n70 123 25 with with IN cord-262892-n38r8n70 123 26 HIV HIV NNP cord-262892-n38r8n70 123 27 , , , cord-262892-n38r8n70 123 28 in in IN cord-262892-n38r8n70 123 29 whom whom WP cord-262892-n38r8n70 123 30 PI pi NN cord-262892-n38r8n70 123 31 - - HYPH cord-262892-n38r8n70 123 32 based base VBN cord-262892-n38r8n70 123 33 therapy therapy NN cord-262892-n38r8n70 123 34 was be VBD cord-262892-n38r8n70 123 35 initiated initiate VBN cord-262892-n38r8n70 123 36 and and CC cord-262892-n38r8n70 123 37 maintained maintain VBN cord-262892-n38r8n70 123 38 for for IN cord-262892-n38r8n70 123 39 a a DT cord-262892-n38r8n70 123 40 median median NN cord-262892-n38r8n70 123 41 of of IN cord-262892-n38r8n70 123 42 5 5 CD cord-262892-n38r8n70 123 43 months month NNS cord-262892-n38r8n70 123 44 . . . cord-262892-n38r8n70 124 1 These these DT cord-262892-n38r8n70 124 2 effects effect NNS cord-262892-n38r8n70 124 3 were be VBD cord-262892-n38r8n70 124 4 independent independent JJ cord-262892-n38r8n70 124 5 of of IN cord-262892-n38r8n70 124 6 virologic virologic NNP cord-262892-n38r8n70 124 7 suppression suppression NN cord-262892-n38r8n70 124 8 and and CC cord-262892-n38r8n70 124 9 improved improve VBD cord-262892-n38r8n70 124 10 CD4 CD4 NNP cord-262892-n38r8n70 124 11 T T NNP cord-262892-n38r8n70 124 12 - - HYPH cord-262892-n38r8n70 124 13 lymphocyte lymphocyte NN cord-262892-n38r8n70 124 14 counts count NNS cord-262892-n38r8n70 124 15 [ [ -LRB- cord-262892-n38r8n70 124 16 40 40 CD cord-262892-n38r8n70 124 17 ] ] -RRB- cord-262892-n38r8n70 124 18 . . . cord-262892-n38r8n70 125 1 These these DT cord-262892-n38r8n70 125 2 findings finding NNS cord-262892-n38r8n70 125 3 were be VBD cord-262892-n38r8n70 125 4 also also RB cord-262892-n38r8n70 125 5 noted note VBN cord-262892-n38r8n70 125 6 in in IN cord-262892-n38r8n70 125 7 the the DT cord-262892-n38r8n70 125 8 Pediatric Pediatric NNP cord-262892-n38r8n70 125 9 AIDS AIDS NNP cord-262892-n38r8n70 125 10 Clinical Clinical NNP cord-262892-n38r8n70 125 11 Trial Trial NNP cord-262892-n38r8n70 125 12 Group Group NNP cord-262892-n38r8n70 125 13 219 219 CD cord-262892-n38r8n70 125 14 study study NN cord-262892-n38r8n70 125 15 , , , cord-262892-n38r8n70 125 16 which which WDT cord-262892-n38r8n70 125 17 II II NNP cord-262892-n38r8n70 125 18 . . . cord-262892-n38r8n70 126 1 NUTRITION NUTRITION NNP cord-262892-n38r8n70 126 2 AND and CC cord-262892-n38r8n70 126 3 LIFESTYLE lifestyle NN cord-262892-n38r8n70 126 4 found find VBD cord-262892-n38r8n70 126 5 that that IN cord-262892-n38r8n70 126 6 PI pi NN cord-262892-n38r8n70 126 7 therapy therapy NN cord-262892-n38r8n70 126 8 improved improve VBD cord-262892-n38r8n70 126 9 both both CC cord-262892-n38r8n70 126 10 weight weight NN cord-262892-n38r8n70 126 11 and and CC cord-262892-n38r8n70 126 12 height height NN cord-262892-n38r8n70 126 13 Z z NN cord-262892-n38r8n70 126 14 - - HYPH cord-262892-n38r8n70 126 15 score score NN cord-262892-n38r8n70 126 16 annually annually RB cord-262892-n38r8n70 126 17 , , , cord-262892-n38r8n70 126 18 after after IN cord-262892-n38r8n70 126 19 adjusting adjust VBG cord-262892-n38r8n70 126 20 for for IN cord-262892-n38r8n70 126 21 CD4 CD4 NNP cord-262892-n38r8n70 126 22 cell cell NN cord-262892-n38r8n70 126 23 count count NN cord-262892-n38r8n70 126 24 , , , cord-262892-n38r8n70 126 25 age age NN cord-262892-n38r8n70 126 26 , , , cord-262892-n38r8n70 126 27 gender gender NN cord-262892-n38r8n70 126 28 , , , cord-262892-n38r8n70 126 29 and and CC cord-262892-n38r8n70 126 30 race race NN cord-262892-n38r8n70 126 31 [ [ -LRB- cord-262892-n38r8n70 126 32 41 41 CD cord-262892-n38r8n70 126 33 ] ] -RRB- cord-262892-n38r8n70 126 34 . . . cord-262892-n38r8n70 127 1 In in IN cord-262892-n38r8n70 127 2 the the DT cord-262892-n38r8n70 127 3 era era NN cord-262892-n38r8n70 127 4 of of IN cord-262892-n38r8n70 127 5 cART cART NNP cord-262892-n38r8n70 127 6 , , , cord-262892-n38r8n70 127 7 following follow VBG cord-262892-n38r8n70 127 8 the the DT cord-262892-n38r8n70 127 9 introduction introduction NN cord-262892-n38r8n70 127 10 of of IN cord-262892-n38r8n70 127 11 PI pi NN cord-262892-n38r8n70 127 12 - - HYPH cord-262892-n38r8n70 127 13 containing contain VBG cord-262892-n38r8n70 127 14 regimens regimen NNS cord-262892-n38r8n70 127 15 , , , cord-262892-n38r8n70 127 16 HIV HIV NNP cord-262892-n38r8n70 127 17 - - HYPH cord-262892-n38r8n70 127 18 associated associate VBN cord-262892-n38r8n70 127 19 mortality mortality NN cord-262892-n38r8n70 127 20 decreased decrease VBD cord-262892-n38r8n70 127 21 by by IN cord-262892-n38r8n70 127 22 greater great JJR cord-262892-n38r8n70 127 23 than than IN cord-262892-n38r8n70 127 24 80 80 CD cord-262892-n38r8n70 127 25 - - SYM cord-262892-n38r8n70 127 26 90 90 CD cord-262892-n38r8n70 127 27 % % NN cord-262892-n38r8n70 127 28 , , , cord-262892-n38r8n70 127 29 with with IN cord-262892-n38r8n70 127 30 significant significant JJ cord-262892-n38r8n70 127 31 declines decline NNS cord-262892-n38r8n70 127 32 in in IN cord-262892-n38r8n70 127 33 opportunistic opportunistic JJ cord-262892-n38r8n70 127 34 and and CC cord-262892-n38r8n70 127 35 related related JJ cord-262892-n38r8n70 127 36 infections infection NNS cord-262892-n38r8n70 127 37 [ [ -LRB- cord-262892-n38r8n70 127 38 31 31 CD cord-262892-n38r8n70 127 39 , , , cord-262892-n38r8n70 127 40 32 32 CD cord-262892-n38r8n70 127 41 ] ] -RRB- cord-262892-n38r8n70 127 42 . . . cord-262892-n38r8n70 128 1 These these DT cord-262892-n38r8n70 128 2 encouraging encouraging JJ cord-262892-n38r8n70 128 3 outcomes outcome NNS cord-262892-n38r8n70 128 4 have have VBP cord-262892-n38r8n70 128 5 been be VBN cord-262892-n38r8n70 128 6 tempered temper VBN cord-262892-n38r8n70 128 7 by by IN cord-262892-n38r8n70 128 8 the the DT cord-262892-n38r8n70 128 9 side side NN cord-262892-n38r8n70 128 10 effects effect NNS cord-262892-n38r8n70 128 11 associated associate VBN cord-262892-n38r8n70 128 12 with with IN cord-262892-n38r8n70 128 13 ARVs arv NNS cord-262892-n38r8n70 128 14 . . . cord-262892-n38r8n70 129 1 Altered altered JJ cord-262892-n38r8n70 129 2 body body NN cord-262892-n38r8n70 129 3 composition composition NN cord-262892-n38r8n70 129 4 , , , cord-262892-n38r8n70 129 5 lipid lipid NN cord-262892-n38r8n70 129 6 abnormalities abnormality NNS cord-262892-n38r8n70 129 7 , , , cord-262892-n38r8n70 129 8 and and CC cord-262892-n38r8n70 129 9 abnormal abnormal JJ cord-262892-n38r8n70 129 10 regulation regulation NN cord-262892-n38r8n70 129 11 of of IN cord-262892-n38r8n70 129 12 glucose glucose NN cord-262892-n38r8n70 129 13 metabolism metabolism NN cord-262892-n38r8n70 129 14 are be VBP cord-262892-n38r8n70 129 15 consequences consequence NNS cord-262892-n38r8n70 129 16 that that WDT cord-262892-n38r8n70 129 17 result result VBP cord-262892-n38r8n70 129 18 in in IN cord-262892-n38r8n70 129 19 an an DT cord-262892-n38r8n70 129 20 increased increase VBN cord-262892-n38r8n70 129 21 risk risk NN cord-262892-n38r8n70 129 22 of of IN cord-262892-n38r8n70 129 23 cardiovascular cardiovascular JJ cord-262892-n38r8n70 129 24 disease disease NN cord-262892-n38r8n70 129 25 , , , cord-262892-n38r8n70 129 26 reflecting reflect VBG cord-262892-n38r8n70 129 27 complications complication NNS cord-262892-n38r8n70 129 28 of of IN cord-262892-n38r8n70 129 29 inflammation inflammation NN cord-262892-n38r8n70 129 30 with with IN cord-262892-n38r8n70 129 31 uncontrolled uncontrolled JJ cord-262892-n38r8n70 129 32 HIV HIV NNP cord-262892-n38r8n70 129 33 infection infection NN cord-262892-n38r8n70 129 34 and and CC cord-262892-n38r8n70 129 35 the the DT cord-262892-n38r8n70 129 36 specific specific JJ cord-262892-n38r8n70 129 37 ARV ARV NNP cord-262892-n38r8n70 129 38 drugs drug NNS cord-262892-n38r8n70 129 39 as as IN cord-262892-n38r8n70 129 40 outlined outline VBN cord-262892-n38r8n70 129 41 . . . cord-262892-n38r8n70 130 1 In in IN cord-262892-n38r8n70 130 2 children child NNS cord-262892-n38r8n70 130 3 , , , cord-262892-n38r8n70 130 4 adolescents adolescent NNS cord-262892-n38r8n70 130 5 , , , cord-262892-n38r8n70 130 6 and and CC cord-262892-n38r8n70 130 7 adults adult NNS cord-262892-n38r8n70 130 8 , , , cord-262892-n38r8n70 130 9 a a DT cord-262892-n38r8n70 130 10 clear clear JJ cord-262892-n38r8n70 130 11 syndrome syndrome NN cord-262892-n38r8n70 130 12 of of IN cord-262892-n38r8n70 130 13 abnormal abnormal JJ cord-262892-n38r8n70 130 14 fat fat JJ cord-262892-n38r8n70 130 15 redistribution redistribution NN cord-262892-n38r8n70 130 16 or or CC cord-262892-n38r8n70 130 17 lipodystrophy lipodystrophy NN cord-262892-n38r8n70 130 18 and and CC cord-262892-n38r8n70 130 19 metabolic metabolic JJ cord-262892-n38r8n70 130 20 changes change NNS cord-262892-n38r8n70 130 21 associated associate VBN cord-262892-n38r8n70 130 22 with with IN cord-262892-n38r8n70 130 23 administration administration NN cord-262892-n38r8n70 130 24 of of IN cord-262892-n38r8n70 130 25 cART cART NNP cord-262892-n38r8n70 130 26 is be VBZ cord-262892-n38r8n70 130 27 well well RB cord-262892-n38r8n70 130 28 described describe VBN cord-262892-n38r8n70 130 29 . . . cord-262892-n38r8n70 131 1 Patterns pattern NNS cord-262892-n38r8n70 131 2 of of IN cord-262892-n38r8n70 131 3 lipodystrophy lipodystrophy NN cord-262892-n38r8n70 131 4 vary vary VBP cord-262892-n38r8n70 131 5 from from IN cord-262892-n38r8n70 131 6 peripheral peripheral JJ cord-262892-n38r8n70 131 7 fat fat NN cord-262892-n38r8n70 131 8 wasting wasting NN cord-262892-n38r8n70 131 9 , , , cord-262892-n38r8n70 131 10 or or CC cord-262892-n38r8n70 131 11 lipoatrophy lipoatrophy NN cord-262892-n38r8n70 131 12 , , , cord-262892-n38r8n70 131 13 in in IN cord-262892-n38r8n70 131 14 the the DT cord-262892-n38r8n70 131 15 face face NN cord-262892-n38r8n70 131 16 , , , cord-262892-n38r8n70 131 17 extremities extremity NNS cord-262892-n38r8n70 131 18 , , , cord-262892-n38r8n70 131 19 and and CC cord-262892-n38r8n70 131 20 buttocks buttock NNS cord-262892-n38r8n70 131 21 to to IN cord-262892-n38r8n70 131 22 central central JJ cord-262892-n38r8n70 131 23 fat fat JJ cord-262892-n38r8n70 131 24 accumulation accumulation NN cord-262892-n38r8n70 131 25 , , , cord-262892-n38r8n70 131 26 or or CC cord-262892-n38r8n70 131 27 lipohypertrophy lipohypertrophy NN cord-262892-n38r8n70 131 28 , , , cord-262892-n38r8n70 131 29 in in IN cord-262892-n38r8n70 131 30 the the DT cord-262892-n38r8n70 131 31 abdomen abdomen NN cord-262892-n38r8n70 131 32 , , , cord-262892-n38r8n70 131 33 dorsocervical dorsocervical JJ cord-262892-n38r8n70 131 34 spine spine NN cord-262892-n38r8n70 131 35 regions region NNS cord-262892-n38r8n70 131 36 ( ( -LRB- cord-262892-n38r8n70 131 37 buffalo buffalo NNP cord-262892-n38r8n70 131 38 hump hump NNP cord-262892-n38r8n70 131 39 ) ) -RRB- cord-262892-n38r8n70 131 40 , , , cord-262892-n38r8n70 131 41 and and CC cord-262892-n38r8n70 131 42 breasts breast NNS cord-262892-n38r8n70 131 43 . . . cord-262892-n38r8n70 132 1 Both both DT cord-262892-n38r8n70 132 2 conditions condition NNS cord-262892-n38r8n70 132 3 may may MD cord-262892-n38r8n70 132 4 occur occur VB cord-262892-n38r8n70 132 5 alone alone JJ cord-262892-n38r8n70 132 6 or or CC cord-262892-n38r8n70 132 7 in in IN cord-262892-n38r8n70 132 8 combination combination NN cord-262892-n38r8n70 132 9 [ [ -LRB- cord-262892-n38r8n70 132 10 42 42 CD cord-262892-n38r8n70 132 11 , , , cord-262892-n38r8n70 132 12 43 43 CD cord-262892-n38r8n70 132 13 ] ] -RRB- cord-262892-n38r8n70 132 14 and and CC cord-262892-n38r8n70 132 15 can can MD cord-262892-n38r8n70 132 16 be be VB cord-262892-n38r8n70 132 17 difficult difficult JJ cord-262892-n38r8n70 132 18 to to TO cord-262892-n38r8n70 132 19 assess assess VB cord-262892-n38r8n70 132 20 in in IN cord-262892-n38r8n70 132 21 a a DT cord-262892-n38r8n70 132 22 growing grow VBG cord-262892-n38r8n70 132 23 child child NN cord-262892-n38r8n70 132 24 or or CC cord-262892-n38r8n70 132 25 adolescent adolescent JJ cord-262892-n38r8n70 132 26 , , , cord-262892-n38r8n70 132 27 since since IN cord-262892-n38r8n70 132 28 changes change NNS cord-262892-n38r8n70 132 29 in in IN cord-262892-n38r8n70 132 30 body body NN cord-262892-n38r8n70 132 31 fat fat NN cord-262892-n38r8n70 132 32 occur occur VBP cord-262892-n38r8n70 132 33 normally normally RB cord-262892-n38r8n70 132 34 during during IN cord-262892-n38r8n70 132 35 childhood childhood NN cord-262892-n38r8n70 132 36 and and CC cord-262892-n38r8n70 132 37 puberty puberty NN cord-262892-n38r8n70 132 38 [ [ -LRB- cord-262892-n38r8n70 132 39 44 44 CD cord-262892-n38r8n70 132 40 ] ] -RRB- cord-262892-n38r8n70 132 41 . . . cord-262892-n38r8n70 133 1 Lipodystrophy Lipodystrophy NNP cord-262892-n38r8n70 133 2 in in IN cord-262892-n38r8n70 133 3 children child NNS cord-262892-n38r8n70 133 4 with with IN cord-262892-n38r8n70 133 5 HIV HIV NNP cord-262892-n38r8n70 133 6 is be VBZ cord-262892-n38r8n70 133 7 clinically clinically RB cord-262892-n38r8n70 133 8 evaluated evaluate VBN cord-262892-n38r8n70 133 9 by by IN cord-262892-n38r8n70 133 10 examination examination NN cord-262892-n38r8n70 133 11 or or CC cord-262892-n38r8n70 133 12 self self NN cord-262892-n38r8n70 133 13 - - HYPH cord-262892-n38r8n70 133 14 report report NN cord-262892-n38r8n70 133 15 and and CC cord-262892-n38r8n70 133 16 has have VBZ cord-262892-n38r8n70 133 17 been be VBN cord-262892-n38r8n70 133 18 documented document VBN cord-262892-n38r8n70 133 19 to to TO cord-262892-n38r8n70 133 20 be be VB cord-262892-n38r8n70 133 21 as as RB cord-262892-n38r8n70 133 22 high high JJ cord-262892-n38r8n70 133 23 as as IN cord-262892-n38r8n70 133 24 32 32 CD cord-262892-n38r8n70 133 25 % % NN cord-262892-n38r8n70 133 26 [ [ -LRB- cord-262892-n38r8n70 133 27 45 45 CD cord-262892-n38r8n70 133 28 ] ] -RRB- cord-262892-n38r8n70 133 29 . . . cord-262892-n38r8n70 134 1 Dual dual JJ cord-262892-n38r8n70 134 2 - - HYPH cord-262892-n38r8n70 134 3 energy energy NN cord-262892-n38r8n70 134 4 X x NN cord-262892-n38r8n70 134 5 - - NN cord-262892-n38r8n70 134 6 ray ray NN cord-262892-n38r8n70 134 7 absorptiometry absorptiometry NN cord-262892-n38r8n70 134 8 ( ( -LRB- cord-262892-n38r8n70 134 9 DEXA DEXA NNP cord-262892-n38r8n70 134 10 ) ) -RRB- cord-262892-n38r8n70 134 11 quantifies quantify VBZ cord-262892-n38r8n70 134 12 total total JJ cord-262892-n38r8n70 134 13 , , , cord-262892-n38r8n70 134 14 trunk trunk NN cord-262892-n38r8n70 134 15 , , , cord-262892-n38r8n70 134 16 and and CC cord-262892-n38r8n70 134 17 limb limb NN cord-262892-n38r8n70 134 18 fat fat NN cord-262892-n38r8n70 134 19 . . . cord-262892-n38r8n70 135 1 Observational observational JJ cord-262892-n38r8n70 135 2 studies study NNS cord-262892-n38r8n70 135 3 in in IN cord-262892-n38r8n70 135 4 children child NNS cord-262892-n38r8n70 135 5 with with IN cord-262892-n38r8n70 135 6 lipodystrophy lipodystrophy NNP cord-262892-n38r8n70 135 7 show show NN cord-262892-n38r8n70 135 8 decreased decrease VBD cord-262892-n38r8n70 135 9 total total JJ cord-262892-n38r8n70 135 10 and and CC cord-262892-n38r8n70 135 11 extremity extremity NN cord-262892-n38r8n70 135 12 fat fat NN cord-262892-n38r8n70 135 13 and and CC cord-262892-n38r8n70 135 14 a a DT cord-262892-n38r8n70 135 15 greater great JJR cord-262892-n38r8n70 135 16 trunk trunk NN cord-262892-n38r8n70 135 17 - - HYPH cord-262892-n38r8n70 135 18 to to IN cord-262892-n38r8n70 135 19 - - HYPH cord-262892-n38r8n70 135 20 extremity extremity NN cord-262892-n38r8n70 135 21 fat fat JJ cord-262892-n38r8n70 135 22 ratio ratio NN cord-262892-n38r8n70 135 23 in in IN cord-262892-n38r8n70 135 24 children child NNS cord-262892-n38r8n70 135 25 with with IN cord-262892-n38r8n70 135 26 HIV HIV NNP cord-262892-n38r8n70 135 27 compared compare VBN cord-262892-n38r8n70 135 28 with with IN cord-262892-n38r8n70 135 29 uninfected uninfected JJ cord-262892-n38r8n70 135 30 children child NNS cord-262892-n38r8n70 135 31 [ [ -LRB- cord-262892-n38r8n70 135 32 46 46 CD cord-262892-n38r8n70 135 33 , , , cord-262892-n38r8n70 135 34 47 47 CD cord-262892-n38r8n70 135 35 ] ] -RRB- cord-262892-n38r8n70 136 1 These these DT cord-262892-n38r8n70 136 2 changes change NNS cord-262892-n38r8n70 136 3 are be VBP cord-262892-n38r8n70 136 4 drug drug NN cord-262892-n38r8n70 136 5 specific specific JJ cord-262892-n38r8n70 136 6 and and CC cord-262892-n38r8n70 136 7 associated associate VBN cord-262892-n38r8n70 136 8 with with IN cord-262892-n38r8n70 136 9 duration duration NN cord-262892-n38r8n70 136 10 of of IN cord-262892-n38r8n70 136 11 therapy therapy NN cord-262892-n38r8n70 136 12 , , , cord-262892-n38r8n70 136 13 with with IN cord-262892-n38r8n70 136 14 prolonged prolong VBN cord-262892-n38r8n70 136 15 treatment treatment NN cord-262892-n38r8n70 136 16 and and CC cord-262892-n38r8n70 136 17 older old JJR cord-262892-n38r8n70 136 18 age age NN cord-262892-n38r8n70 136 19 more more RBR cord-262892-n38r8n70 136 20 likely likely JJ cord-262892-n38r8n70 136 21 to to TO cord-262892-n38r8n70 136 22 result result VB cord-262892-n38r8n70 136 23 in in IN cord-262892-n38r8n70 136 24 lipodystrophy lipodystrophy NN cord-262892-n38r8n70 136 25 . . . cord-262892-n38r8n70 137 1 Treatment treatment NN cord-262892-n38r8n70 137 2 with with IN cord-262892-n38r8n70 137 3 NRTIs nrti NNS cord-262892-n38r8n70 137 4 , , , cord-262892-n38r8n70 137 5 including include VBG cord-262892-n38r8n70 137 6 stavudine stavudine NN cord-262892-n38r8n70 137 7 ( ( -LRB- cord-262892-n38r8n70 137 8 d4 d4 NNP cord-262892-n38r8n70 137 9 T T NNP cord-262892-n38r8n70 137 10 ) ) -RRB- cord-262892-n38r8n70 137 11 , , , cord-262892-n38r8n70 137 12 zidovudine zidovudine FW cord-262892-n38r8n70 137 13 ( ( -LRB- cord-262892-n38r8n70 137 14 AZT AZT NNP cord-262892-n38r8n70 137 15 ) ) -RRB- cord-262892-n38r8n70 137 16 , , , cord-262892-n38r8n70 137 17 and and CC cord-262892-n38r8n70 137 18 didanosine didanosine NNP cord-262892-n38r8n70 137 19 ( ( -LRB- cord-262892-n38r8n70 137 20 ddI ddI NNP cord-262892-n38r8n70 137 21 ) ) -RRB- cord-262892-n38r8n70 137 22 , , , cord-262892-n38r8n70 137 23 is be VBZ cord-262892-n38r8n70 137 24 associated associate VBN cord-262892-n38r8n70 137 25 with with IN cord-262892-n38r8n70 137 26 a a DT cord-262892-n38r8n70 137 27 lower low JJR cord-262892-n38r8n70 137 28 percentage percentage NN cord-262892-n38r8n70 137 29 of of IN cord-262892-n38r8n70 137 30 extremity extremity NN cord-262892-n38r8n70 137 31 fat fat NN cord-262892-n38r8n70 137 32 and and CC cord-262892-n38r8n70 137 33 higher high JJR cord-262892-n38r8n70 137 34 percentage percentage NN cord-262892-n38r8n70 137 35 of of IN cord-262892-n38r8n70 137 36 trunk trunk NN cord-262892-n38r8n70 137 37 fat fat NN cord-262892-n38r8n70 137 38 and and CC cord-262892-n38r8n70 137 39 trunk trunk NN cord-262892-n38r8n70 137 40 - - HYPH cord-262892-n38r8n70 137 41 to to IN cord-262892-n38r8n70 137 42 - - HYPH cord-262892-n38r8n70 137 43 extremity extremity NN cord-262892-n38r8n70 137 44 fat fat JJ cord-262892-n38r8n70 137 45 ratio ratio NN cord-262892-n38r8n70 137 46 even even RB cord-262892-n38r8n70 137 47 after after IN cord-262892-n38r8n70 137 48 adjustment adjustment NN cord-262892-n38r8n70 137 49 for for IN cord-262892-n38r8n70 137 50 wasting waste VBG cord-262892-n38r8n70 137 51 and and CC cord-262892-n38r8n70 137 52 stunting stunt VBG cord-262892-n38r8n70 137 53 [ [ -LRB- cord-262892-n38r8n70 137 54 21 21 CD cord-262892-n38r8n70 137 55 , , , cord-262892-n38r8n70 137 56 43 43 CD cord-262892-n38r8n70 137 57 ] ] -RRB- cord-262892-n38r8n70 137 58 . . . cord-262892-n38r8n70 138 1 These these DT cord-262892-n38r8n70 138 2 changes change NNS cord-262892-n38r8n70 138 3 in in IN cord-262892-n38r8n70 138 4 body body NN cord-262892-n38r8n70 138 5 fat fat NN cord-262892-n38r8n70 138 6 distribution distribution NN cord-262892-n38r8n70 138 7 often often RB cord-262892-n38r8n70 138 8 can can MD cord-262892-n38r8n70 138 9 not not RB cord-262892-n38r8n70 138 10 be be VB cord-262892-n38r8n70 138 11 reversed reverse VBN cord-262892-n38r8n70 138 12 even even RB cord-262892-n38r8n70 138 13 after after IN cord-262892-n38r8n70 138 14 switching switch VBG cord-262892-n38r8n70 138 15 to to IN cord-262892-n38r8n70 138 16 less less JJR cord-262892-n38r8n70 138 17 lipodystrophic lipodystrophic JJ cord-262892-n38r8n70 138 18 ARV ARV NNP cord-262892-n38r8n70 138 19 regimens regimen NNS cord-262892-n38r8n70 138 20 . . . cord-262892-n38r8n70 139 1 In in IN cord-262892-n38r8n70 139 2 cohorts cohort NNS cord-262892-n38r8n70 139 3 of of IN cord-262892-n38r8n70 139 4 children child NNS cord-262892-n38r8n70 139 5 receiving receive VBG cord-262892-n38r8n70 139 6 a a DT cord-262892-n38r8n70 139 7 PI pi NN cord-262892-n38r8n70 139 8 regimen regimen NN cord-262892-n38r8n70 139 9 , , , cord-262892-n38r8n70 139 10 higher high JJR cord-262892-n38r8n70 139 11 rates rate NNS cord-262892-n38r8n70 139 12 of of IN cord-262892-n38r8n70 139 13 dyslipidemia dyslipidemia NN cord-262892-n38r8n70 139 14 have have VBP cord-262892-n38r8n70 139 15 been be VBN cord-262892-n38r8n70 139 16 documented document VBN cord-262892-n38r8n70 139 17 , , , cord-262892-n38r8n70 139 18 with with IN cord-262892-n38r8n70 139 19 higher high JJR cord-262892-n38r8n70 139 20 fasting fast VBG cord-262892-n38r8n70 139 21 lipids lipid NNS cord-262892-n38r8n70 139 22 , , , cord-262892-n38r8n70 139 23 cholesterol cholesterol NN cord-262892-n38r8n70 139 24 , , , cord-262892-n38r8n70 139 25 and and CC cord-262892-n38r8n70 139 26 triglycerides triglyceride NNS cord-262892-n38r8n70 139 27 . . . cord-262892-n38r8n70 140 1 Lipodystrophy Lipodystrophy NNP cord-262892-n38r8n70 140 2 in in IN cord-262892-n38r8n70 140 3 patients patient NNS cord-262892-n38r8n70 140 4 results result NNS cord-262892-n38r8n70 140 5 in in IN cord-262892-n38r8n70 140 6 much much RB cord-262892-n38r8n70 140 7 higher high JJR cord-262892-n38r8n70 140 8 waist waist NN cord-262892-n38r8n70 140 9 - - HYPH cord-262892-n38r8n70 140 10 tohip tohip NN cord-262892-n38r8n70 140 11 ratios ratio NNS cord-262892-n38r8n70 140 12 and and CC cord-262892-n38r8n70 140 13 elevated elevate VBN cord-262892-n38r8n70 140 14 fasting fast VBG cord-262892-n38r8n70 140 15 insulin insulin NN cord-262892-n38r8n70 140 16 levels level NNS cord-262892-n38r8n70 140 17 and and CC cord-262892-n38r8n70 140 18 blood blood NN cord-262892-n38r8n70 140 19 pressure pressure NN cord-262892-n38r8n70 140 20 , , , cord-262892-n38r8n70 140 21 which which WDT cord-262892-n38r8n70 140 22 II II NNP cord-262892-n38r8n70 140 23 . . . cord-262892-n38r8n70 141 1 NUTRITION NUTRITION NNP cord-262892-n38r8n70 141 2 AND and CC cord-262892-n38r8n70 141 3 LIFESTYLE lifestyle NN cord-262892-n38r8n70 141 4 are be VBP cord-262892-n38r8n70 141 5 all all DT cord-262892-n38r8n70 141 6 significant significant JJ cord-262892-n38r8n70 141 7 risk risk NN cord-262892-n38r8n70 141 8 factors factor NNS cord-262892-n38r8n70 141 9 for for IN cord-262892-n38r8n70 141 10 cardiovascular cardiovascular JJ cord-262892-n38r8n70 141 11 disease disease NN cord-262892-n38r8n70 141 12 [ [ -LRB- cord-262892-n38r8n70 141 13 21 21 CD cord-262892-n38r8n70 141 14 ] ] -RRB- cord-262892-n38r8n70 141 15 . . . cord-262892-n38r8n70 142 1 For for IN cord-262892-n38r8n70 142 2 children child NNS cord-262892-n38r8n70 142 3 without without IN cord-262892-n38r8n70 142 4 lipodystrophy lipodystrophy NNP cord-262892-n38r8n70 142 5 , , , cord-262892-n38r8n70 142 6 up up IN cord-262892-n38r8n70 142 7 to to IN cord-262892-n38r8n70 142 8 one one CD cord-262892-n38r8n70 142 9 fifth fifth JJ cord-262892-n38r8n70 142 10 show show NN cord-262892-n38r8n70 142 11 symptoms symptom NNS cord-262892-n38r8n70 142 12 of of IN cord-262892-n38r8n70 142 13 dyslipidemia dyslipidemia NN cord-262892-n38r8n70 142 14 . . . cord-262892-n38r8n70 143 1 In in IN cord-262892-n38r8n70 143 2 summary summary NN cord-262892-n38r8n70 143 3 , , , cord-262892-n38r8n70 143 4 when when WRB cord-262892-n38r8n70 143 5 selecting select VBG cord-262892-n38r8n70 143 6 ARV ARV NNP cord-262892-n38r8n70 143 7 regimens regimen NNS cord-262892-n38r8n70 143 8 , , , cord-262892-n38r8n70 143 9 care care NN cord-262892-n38r8n70 143 10 must must MD cord-262892-n38r8n70 143 11 be be VB cord-262892-n38r8n70 143 12 taken take VBN cord-262892-n38r8n70 143 13 to to TO cord-262892-n38r8n70 143 14 consider consider VB cord-262892-n38r8n70 143 15 the the DT cord-262892-n38r8n70 143 16 above above JJ cord-262892-n38r8n70 143 17 life life NN cord-262892-n38r8n70 143 18 - - HYPH cord-262892-n38r8n70 143 19 long long JJ cord-262892-n38r8n70 143 20 side side NN cord-262892-n38r8n70 143 21 effects effect NNS cord-262892-n38r8n70 143 22 and and CC cord-262892-n38r8n70 143 23 their -PRON- PRP$ cord-262892-n38r8n70 143 24 consequences consequence NNS cord-262892-n38r8n70 143 25 . . . cord-262892-n38r8n70 144 1 At at IN cord-262892-n38r8n70 144 2 a a DT cord-262892-n38r8n70 144 3 time time NN cord-262892-n38r8n70 144 4 when when WRB cord-262892-n38r8n70 144 5 newer new JJR cord-262892-n38r8n70 144 6 less less JJR cord-262892-n38r8n70 144 7 lipodystrophic lipodystrophic JJ cord-262892-n38r8n70 144 8 first first JJ cord-262892-n38r8n70 144 9 - - HYPH cord-262892-n38r8n70 144 10 line line NN cord-262892-n38r8n70 144 11 regimens regimen NNS cord-262892-n38r8n70 144 12 , , , cord-262892-n38r8n70 144 13 including include VBG cord-262892-n38r8n70 144 14 tenofovir tenofovir NNP cord-262892-n38r8n70 144 15 , , , cord-262892-n38r8n70 144 16 abacavir abacavir NNP cord-262892-n38r8n70 144 17 , , , cord-262892-n38r8n70 144 18 ritonavir ritonavir NNP cord-262892-n38r8n70 144 19 - - HYPH cord-262892-n38r8n70 144 20 boosted boost VBN cord-262892-n38r8n70 144 21 PIs pi NNS cord-262892-n38r8n70 144 22 ( ( -LRB- cord-262892-n38r8n70 144 23 atazanavir atazanavir NNP cord-262892-n38r8n70 144 24 and and CC cord-262892-n38r8n70 144 25 darunavir darunavir NNP cord-262892-n38r8n70 144 26 ) ) -RRB- cord-262892-n38r8n70 144 27 , , , cord-262892-n38r8n70 144 28 and and CC cord-262892-n38r8n70 144 29 the the DT cord-262892-n38r8n70 144 30 integrase integrase NN cord-262892-n38r8n70 144 31 inhibitors inhibitor NNS cord-262892-n38r8n70 144 32 , , , cord-262892-n38r8n70 144 33 most most JJS cord-262892-n38r8n70 144 34 with with IN cord-262892-n38r8n70 144 35 the the DT cord-262892-n38r8n70 144 36 added add VBN cord-262892-n38r8n70 144 37 advantage advantage NN cord-262892-n38r8n70 144 38 of of IN cord-262892-n38r8n70 144 39 once once RB cord-262892-n38r8n70 144 40 daily daily JJ cord-262892-n38r8n70 144 41 administration administration NN cord-262892-n38r8n70 144 42 , , , cord-262892-n38r8n70 144 43 are be VBP cord-262892-n38r8n70 144 44 available available JJ cord-262892-n38r8n70 144 45 in in IN cord-262892-n38r8n70 144 46 the the DT cord-262892-n38r8n70 144 47 United United NNP cord-262892-n38r8n70 144 48 States States NNP cord-262892-n38r8n70 144 49 , , , cord-262892-n38r8n70 144 50 regimens regimen NNS cord-262892-n38r8n70 144 51 that that WDT cord-262892-n38r8n70 144 52 include include VBP cord-262892-n38r8n70 144 53 zidovudine zidovudine NN cord-262892-n38r8n70 144 54 , , , cord-262892-n38r8n70 144 55 didanosine didanosine NNP cord-262892-n38r8n70 144 56 , , , cord-262892-n38r8n70 144 57 and and CC cord-262892-n38r8n70 144 58 stavudine stavudine NNP cord-262892-n38r8n70 144 59 should should MD cord-262892-n38r8n70 144 60 be be VB cord-262892-n38r8n70 144 61 prescribed prescribe VBN cord-262892-n38r8n70 144 62 less less RBR cord-262892-n38r8n70 144 63 often often RB cord-262892-n38r8n70 144 64 to to IN cord-262892-n38r8n70 144 65 children child NNS cord-262892-n38r8n70 144 66 with with IN cord-262892-n38r8n70 144 67 HIV HIV NNP cord-262892-n38r8n70 144 68 to to TO cord-262892-n38r8n70 144 69 reduce reduce VB cord-262892-n38r8n70 144 70 these these DT cord-262892-n38r8n70 144 71 potential potential JJ cord-262892-n38r8n70 144 72 long long JJ cord-262892-n38r8n70 144 73 - - HYPH cord-262892-n38r8n70 144 74 term term NN cord-262892-n38r8n70 144 75 toxicities toxicity NNS cord-262892-n38r8n70 144 76 . . . cord-262892-n38r8n70 145 1 Metabolic metabolic JJ cord-262892-n38r8n70 145 2 syndrome syndrome NN cord-262892-n38r8n70 145 3 reflects reflect VBZ cord-262892-n38r8n70 145 4 a a DT cord-262892-n38r8n70 145 5 series series NN cord-262892-n38r8n70 145 6 of of IN cord-262892-n38r8n70 145 7 clinical clinical JJ cord-262892-n38r8n70 145 8 conditions condition NNS cord-262892-n38r8n70 145 9 , , , cord-262892-n38r8n70 145 10 including include VBG cord-262892-n38r8n70 145 11 elevated elevated JJ cord-262892-n38r8n70 145 12 triglyceride triglyceride NN cord-262892-n38r8n70 145 13 , , , cord-262892-n38r8n70 145 14 low low JJ cord-262892-n38r8n70 145 15 levels level NNS cord-262892-n38r8n70 145 16 of of IN cord-262892-n38r8n70 145 17 high high JJ cord-262892-n38r8n70 145 18 - - HYPH cord-262892-n38r8n70 145 19 density density NN cord-262892-n38r8n70 145 20 lipoprotein lipoprotein NN cord-262892-n38r8n70 145 21 ( ( -LRB- cord-262892-n38r8n70 145 22 HDL HDL NNP cord-262892-n38r8n70 145 23 ) ) -RRB- cord-262892-n38r8n70 145 24 cholesterol cholesterol NN cord-262892-n38r8n70 145 25 , , , cord-262892-n38r8n70 145 26 hyperglycemia hyperglycemia NN cord-262892-n38r8n70 145 27 and and CC cord-262892-n38r8n70 145 28 insulin insulin NN cord-262892-n38r8n70 145 29 resistance resistance NN cord-262892-n38r8n70 145 30 , , , cord-262892-n38r8n70 145 31 increased increase VBN cord-262892-n38r8n70 145 32 body body NN cord-262892-n38r8n70 145 33 fat fat NN cord-262892-n38r8n70 145 34 distribution distribution NN cord-262892-n38r8n70 145 35 around around IN cord-262892-n38r8n70 145 36 the the DT cord-262892-n38r8n70 145 37 waist waist NN cord-262892-n38r8n70 145 38 , , , cord-262892-n38r8n70 145 39 and and CC cord-262892-n38r8n70 145 40 high high JJ cord-262892-n38r8n70 145 41 blood blood NN cord-262892-n38r8n70 145 42 pressure pressure NN cord-262892-n38r8n70 145 43 , , , cord-262892-n38r8n70 145 44 all all DT cord-262892-n38r8n70 145 45 of of IN cord-262892-n38r8n70 145 46 which which WDT cord-262892-n38r8n70 145 47 collectively collectively RB cord-262892-n38r8n70 145 48 increase increase VBP cord-262892-n38r8n70 145 49 the the DT cord-262892-n38r8n70 145 50 risk risk NN cord-262892-n38r8n70 145 51 of of IN cord-262892-n38r8n70 145 52 cardiovascular cardiovascular JJ cord-262892-n38r8n70 145 53 disease disease NN cord-262892-n38r8n70 145 54 . . . cord-262892-n38r8n70 146 1 In in IN cord-262892-n38r8n70 146 2 individuals individual NNS cord-262892-n38r8n70 146 3 with with IN cord-262892-n38r8n70 146 4 HIV HIV NNP cord-262892-n38r8n70 146 5 , , , cord-262892-n38r8n70 146 6 the the DT cord-262892-n38r8n70 146 7 prevalence prevalence NN cord-262892-n38r8n70 146 8 of of IN cord-262892-n38r8n70 146 9 metabolic metabolic JJ cord-262892-n38r8n70 146 10 syndrome syndrome NN cord-262892-n38r8n70 146 11 is be VBZ cord-262892-n38r8n70 146 12 higher high JJR cord-262892-n38r8n70 146 13 than than IN cord-262892-n38r8n70 146 14 in in IN cord-262892-n38r8n70 146 15 the the DT cord-262892-n38r8n70 146 16 general general JJ cord-262892-n38r8n70 146 17 population population NN cord-262892-n38r8n70 146 18 and and CC cord-262892-n38r8n70 146 19 estimated estimate VBN cord-262892-n38r8n70 146 20 to to TO cord-262892-n38r8n70 146 21 be be VB cord-262892-n38r8n70 146 22 7 7 CD cord-262892-n38r8n70 146 23 - - SYM cord-262892-n38r8n70 146 24 45 45 CD cord-262892-n38r8n70 146 25 % % NN cord-262892-n38r8n70 146 26 [ [ -LRB- cord-262892-n38r8n70 146 27 21 21 CD cord-262892-n38r8n70 146 28 , , , cord-262892-n38r8n70 146 29 48 48 CD cord-262892-n38r8n70 146 30 ] ] -RRB- cord-262892-n38r8n70 146 31 . . . cord-262892-n38r8n70 147 1 Although although IN cord-262892-n38r8n70 147 2 uncontrolled uncontrolled JJ cord-262892-n38r8n70 147 3 HIV HIV NNP cord-262892-n38r8n70 147 4 in in IN cord-262892-n38r8n70 147 5 the the DT cord-262892-n38r8n70 147 6 absence absence NN cord-262892-n38r8n70 147 7 of of IN cord-262892-n38r8n70 147 8 cART cART NNP cord-262892-n38r8n70 147 9 can can MD cord-262892-n38r8n70 147 10 cause cause VB cord-262892-n38r8n70 147 11 low low JJ cord-262892-n38r8n70 147 12 HDL HDL NNP cord-262892-n38r8n70 147 13 cholesterol cholesterol NN cord-262892-n38r8n70 147 14 and and CC cord-262892-n38r8n70 147 15 high high JJ cord-262892-n38r8n70 147 16 triglycerides triglyceride NNS cord-262892-n38r8n70 147 17 , , , cord-262892-n38r8n70 147 18 as as IN cord-262892-n38r8n70 147 19 discussed discuss VBN cord-262892-n38r8n70 147 20 previously previously RB cord-262892-n38r8n70 147 21 , , , cord-262892-n38r8n70 147 22 ARVs arv NNS cord-262892-n38r8n70 147 23 also also RB cord-262892-n38r8n70 147 24 induce induce VBP cord-262892-n38r8n70 147 25 body body NN cord-262892-n38r8n70 147 26 fat fat JJ cord-262892-n38r8n70 147 27 redistribution redistribution NN cord-262892-n38r8n70 147 28 in in IN cord-262892-n38r8n70 147 29 conjunction conjunction NN cord-262892-n38r8n70 147 30 with with IN cord-262892-n38r8n70 147 31 metabolic metabolic JJ cord-262892-n38r8n70 147 32 changes change NNS cord-262892-n38r8n70 147 33 . . . cord-262892-n38r8n70 148 1 Earlier early JJR cord-262892-n38r8n70 148 2 PIs pi NNS cord-262892-n38r8n70 148 3 , , , cord-262892-n38r8n70 148 4 including include VBG cord-262892-n38r8n70 148 5 treatment treatment NN cord-262892-n38r8n70 148 6 doses dose NNS cord-262892-n38r8n70 148 7 of of IN cord-262892-n38r8n70 148 8 ritonavir ritonavir NNS cord-262892-n38r8n70 148 9 ( ( -LRB- cord-262892-n38r8n70 148 10 without without IN cord-262892-n38r8n70 148 11 boosting boost VBG cord-262892-n38r8n70 148 12 other other JJ cord-262892-n38r8n70 148 13 PIs pi NNS cord-262892-n38r8n70 148 14 ) ) -RRB- cord-262892-n38r8n70 148 15 , , , cord-262892-n38r8n70 148 16 nelfinavir nelfinavir NNP cord-262892-n38r8n70 148 17 , , , cord-262892-n38r8n70 148 18 and and CC cord-262892-n38r8n70 148 19 ritonavir ritonavir NNS cord-262892-n38r8n70 148 20 - - HYPH cord-262892-n38r8n70 148 21 boosted boost VBN cord-262892-n38r8n70 148 22 lopinavir lopinavir NNS cord-262892-n38r8n70 148 23 ( ( -LRB- cord-262892-n38r8n70 148 24 kaletra kaletra NNP cord-262892-n38r8n70 148 25 ) ) -RRB- cord-262892-n38r8n70 148 26 were be VBD cord-262892-n38r8n70 148 27 documented document VBN cord-262892-n38r8n70 148 28 to to TO cord-262892-n38r8n70 148 29 increase increase VB cord-262892-n38r8n70 148 30 lipid lipid NN cord-262892-n38r8n70 148 31 plasma plasma NN cord-262892-n38r8n70 148 32 concentrations concentration NNS cord-262892-n38r8n70 148 33 , , , cord-262892-n38r8n70 148 34 including include VBG cord-262892-n38r8n70 148 35 serum serum NN cord-262892-n38r8n70 148 36 triglycerides triglyceride NNS cord-262892-n38r8n70 148 37 , , , cord-262892-n38r8n70 148 38 cholesterol cholesterol NN cord-262892-n38r8n70 148 39 , , , cord-262892-n38r8n70 148 40 low low JJ cord-262892-n38r8n70 148 41 - - HYPH cord-262892-n38r8n70 148 42 density density NN cord-262892-n38r8n70 148 43 lipoprotein lipoprotein NN cord-262892-n38r8n70 148 44 ( ( -LRB- cord-262892-n38r8n70 148 45 LDL LDL NNP cord-262892-n38r8n70 148 46 ) ) -RRB- cord-262892-n38r8n70 148 47 cholesterol cholesterol NN cord-262892-n38r8n70 148 48 , , , cord-262892-n38r8n70 148 49 and and CC cord-262892-n38r8n70 148 50 apolipoprotein apolipoprotein NN cord-262892-n38r8n70 148 51 E e NN cord-262892-n38r8n70 148 52 and and CC cord-262892-n38r8n70 148 53 to to TO cord-262892-n38r8n70 148 54 lower lower VB cord-262892-n38r8n70 148 55 HDL HDL NNP cord-262892-n38r8n70 148 56 . . . cord-262892-n38r8n70 149 1 Virologic Virologic NNP cord-262892-n38r8n70 149 2 control control NN cord-262892-n38r8n70 149 3 with with IN cord-262892-n38r8n70 149 4 the the DT cord-262892-n38r8n70 149 5 newer new JJR cord-262892-n38r8n70 149 6 PIs pi NNS cord-262892-n38r8n70 149 7 , , , cord-262892-n38r8n70 150 1 integrase integrase NNP cord-262892-n38r8n70 150 2 inhibitors inhibitor NNS cord-262892-n38r8n70 150 3 , , , cord-262892-n38r8n70 150 4 tenofovir tenofovir NNP cord-262892-n38r8n70 150 5 , , , cord-262892-n38r8n70 150 6 and and CC cord-262892-n38r8n70 150 7 abacavir abacavir NNP cord-262892-n38r8n70 150 8 may may MD cord-262892-n38r8n70 150 9 be be VB cord-262892-n38r8n70 150 10 associated associate VBN cord-262892-n38r8n70 150 11 with with IN cord-262892-n38r8n70 150 12 increases increase NNS cord-262892-n38r8n70 150 13 in in IN cord-262892-n38r8n70 150 14 serum serum NN cord-262892-n38r8n70 150 15 HDL hdl NN cord-262892-n38r8n70 150 16 , , , cord-262892-n38r8n70 150 17 in in IN cord-262892-n38r8n70 150 18 the the DT cord-262892-n38r8n70 150 19 absence absence NN cord-262892-n38r8n70 150 20 of of IN cord-262892-n38r8n70 150 21 these these DT cord-262892-n38r8n70 150 22 metabolic metabolic JJ cord-262892-n38r8n70 150 23 complications complication NNS cord-262892-n38r8n70 150 24 . . . cord-262892-n38r8n70 151 1 When when WRB cord-262892-n38r8n70 151 2 compared compare VBN cord-262892-n38r8n70 151 3 with with IN cord-262892-n38r8n70 151 4 population population NN cord-262892-n38r8n70 151 5 norms norm NNS cord-262892-n38r8n70 151 6 , , , cord-262892-n38r8n70 151 7 children child NNS cord-262892-n38r8n70 151 8 with with IN cord-262892-n38r8n70 151 9 HIV HIV NNP cord-262892-n38r8n70 151 10 were be VBD cord-262892-n38r8n70 151 11 noted note VBN cord-262892-n38r8n70 151 12 to to TO cord-262892-n38r8n70 151 13 have have VB cord-262892-n38r8n70 151 14 lower low JJR cord-262892-n38r8n70 151 15 - - HYPH cord-262892-n38r8n70 151 16 than than IN cord-262892-n38r8n70 151 17 - - HYPH cord-262892-n38r8n70 151 18 expected expect VBN cord-262892-n38r8n70 151 19 bone bone NN cord-262892-n38r8n70 151 20 mineral mineral NN cord-262892-n38r8n70 151 21 density density NN cord-262892-n38r8n70 151 22 ( ( -LRB- cord-262892-n38r8n70 151 23 BMD BMD NNP cord-262892-n38r8n70 151 24 ) ) -RRB- cord-262892-n38r8n70 151 25 for for IN cord-262892-n38r8n70 151 26 their -PRON- PRP$ cord-262892-n38r8n70 151 27 age age NN cord-262892-n38r8n70 151 28 and and CC cord-262892-n38r8n70 151 29 gender gender NN cord-262892-n38r8n70 151 30 that that WDT cord-262892-n38r8n70 151 31 may may MD cord-262892-n38r8n70 151 32 have have VB cord-262892-n38r8n70 151 33 been be VBN cord-262892-n38r8n70 151 34 associated associate VBN cord-262892-n38r8n70 151 35 with with IN cord-262892-n38r8n70 151 36 delays delay NNS cord-262892-n38r8n70 151 37 in in IN cord-262892-n38r8n70 151 38 growth growth NN cord-262892-n38r8n70 151 39 , , , cord-262892-n38r8n70 151 40 sexual sexual JJ cord-262892-n38r8n70 151 41 maturity maturity NN cord-262892-n38r8n70 151 42 , , , cord-262892-n38r8n70 151 43 duration duration NN cord-262892-n38r8n70 151 44 of of IN cord-262892-n38r8n70 151 45 HIV HIV NNP cord-262892-n38r8n70 151 46 infection infection NN cord-262892-n38r8n70 151 47 , , , cord-262892-n38r8n70 151 48 ethnicity ethnicity NN cord-262892-n38r8n70 151 49 , , , cord-262892-n38r8n70 151 50 and and CC cord-262892-n38r8n70 151 51 disease disease NN cord-262892-n38r8n70 151 52 severity severity NN cord-262892-n38r8n70 151 53 [ [ -LRB- cord-262892-n38r8n70 151 54 49 49 CD cord-262892-n38r8n70 151 55 ] ] -RRB- cord-262892-n38r8n70 151 56 . . . cord-262892-n38r8n70 152 1 A a DT cord-262892-n38r8n70 152 2 more more RBR cord-262892-n38r8n70 152 3 recent recent JJ cord-262892-n38r8n70 152 4 large large JJ cord-262892-n38r8n70 152 5 study study NN cord-262892-n38r8n70 152 6 of of IN cord-262892-n38r8n70 152 7 236 236 CD cord-262892-n38r8n70 152 8 American american JJ cord-262892-n38r8n70 152 9 children child NNS cord-262892-n38r8n70 152 10 and and CC cord-262892-n38r8n70 152 11 adolescents adolescent NNS cord-262892-n38r8n70 152 12 with with IN cord-262892-n38r8n70 152 13 HIV HIV NNP cord-262892-n38r8n70 152 14 , , , cord-262892-n38r8n70 152 15 aged aged JJ cord-262892-n38r8n70 152 16 7 7 CD cord-262892-n38r8n70 152 17 - - SYM cord-262892-n38r8n70 152 18 24 24 CD cord-262892-n38r8n70 152 19 years year NNS cord-262892-n38r8n70 152 20 , , , cord-262892-n38r8n70 152 21 showed show VBD cord-262892-n38r8n70 152 22 that that IN cord-262892-n38r8n70 152 23 males male NNS cord-262892-n38r8n70 152 24 with with IN cord-262892-n38r8n70 152 25 HIV HIV NNP cord-262892-n38r8n70 152 26 had have VBD cord-262892-n38r8n70 152 27 significantly significantly RB cord-262892-n38r8n70 152 28 lower low JJR cord-262892-n38r8n70 152 29 BMD bmd NN cord-262892-n38r8n70 152 30 at at IN cord-262892-n38r8n70 152 31 Tanner Tanner NNP cord-262892-n38r8n70 152 32 stage stage NN cord-262892-n38r8n70 152 33 5 5 CD cord-262892-n38r8n70 152 34 compared compare VBN cord-262892-n38r8n70 152 35 with with IN cord-262892-n38r8n70 152 36 uninfected uninfected JJ cord-262892-n38r8n70 152 37 males male NNS cord-262892-n38r8n70 152 38 [ [ -LRB- cord-262892-n38r8n70 152 39 50 50 CD cord-262892-n38r8n70 152 40 ] ] -RRB- cord-262892-n38r8n70 152 41 . . . cord-262892-n38r8n70 153 1 Reduced reduce VBN cord-262892-n38r8n70 153 2 BMD bmd NN cord-262892-n38r8n70 153 3 secondary secondary JJ cord-262892-n38r8n70 153 4 to to IN cord-262892-n38r8n70 153 5 cART cART NNP cord-262892-n38r8n70 153 6 administration administration NNP cord-262892-n38r8n70 153 7 was be VBD cord-262892-n38r8n70 153 8 first first RB cord-262892-n38r8n70 153 9 described describe VBN cord-262892-n38r8n70 153 10 in in IN cord-262892-n38r8n70 153 11 2001 2001 CD cord-262892-n38r8n70 153 12 from from IN cord-262892-n38r8n70 153 13 DEXA DEXA NNP cord-262892-n38r8n70 153 14 scans scan NNS cord-262892-n38r8n70 153 15 in in IN cord-262892-n38r8n70 153 16 vertically vertically RB cord-262892-n38r8n70 153 17 infected infect VBN cord-262892-n38r8n70 153 18 children child NNS cord-262892-n38r8n70 153 19 , , , cord-262892-n38r8n70 153 20 with with IN cord-262892-n38r8n70 153 21 the the DT cord-262892-n38r8n70 153 22 severity severity NN cord-262892-n38r8n70 153 23 of of IN cord-262892-n38r8n70 153 24 osteopenia osteopenia NN cord-262892-n38r8n70 153 25 directly directly RB cord-262892-n38r8n70 153 26 related relate VBN cord-262892-n38r8n70 153 27 to to IN cord-262892-n38r8n70 153 28 lipodystrophy lipodystrophy NNP cord-262892-n38r8n70 153 29 [ [ -LRB- cord-262892-n38r8n70 153 30 51 51 CD cord-262892-n38r8n70 153 31 ] ] -RRB- cord-262892-n38r8n70 153 32 . . . cord-262892-n38r8n70 154 1 However however RB cord-262892-n38r8n70 154 2 , , , cord-262892-n38r8n70 154 3 a a DT cord-262892-n38r8n70 154 4 longitudinal longitudinal JJ cord-262892-n38r8n70 154 5 study study NN cord-262892-n38r8n70 154 6 from from IN cord-262892-n38r8n70 154 7 2013 2013 CD cord-262892-n38r8n70 154 8 in in IN cord-262892-n38r8n70 154 9 66 66 CD cord-262892-n38r8n70 154 10 Dutch dutch JJ cord-262892-n38r8n70 154 11 children child NNS cord-262892-n38r8n70 154 12 showed show VBD cord-262892-n38r8n70 154 13 an an DT cord-262892-n38r8n70 154 14 association association NN cord-262892-n38r8n70 154 15 between between IN cord-262892-n38r8n70 154 16 longer long RBR cord-262892-n38r8n70 154 17 cART cART VBN cord-262892-n38r8n70 154 18 duration duration NN cord-262892-n38r8n70 154 19 and and CC cord-262892-n38r8n70 154 20 increases increase NNS cord-262892-n38r8n70 154 21 in in IN cord-262892-n38r8n70 154 22 spinal spinal JJ cord-262892-n38r8n70 154 23 BMD bmd NN cord-262892-n38r8n70 154 24 Z Z NNP cord-262892-n38r8n70 154 25 - - HYPH cord-262892-n38r8n70 154 26 scores score NNS cord-262892-n38r8n70 154 27 [ [ -LRB- cord-262892-n38r8n70 154 28 52 52 CD cord-262892-n38r8n70 154 29 ] ] -RRB- cord-262892-n38r8n70 154 30 . . . cord-262892-n38r8n70 155 1 Lopinavir Lopinavir NNP cord-262892-n38r8n70 155 2 - - HYPH cord-262892-n38r8n70 155 3 ritonavir ritonavir NNP cord-262892-n38r8n70 155 4 II II NNP cord-262892-n38r8n70 155 5 . . . cord-262892-n38r8n70 156 1 NUTRITION NUTRITION NNP cord-262892-n38r8n70 156 2 AND and CC cord-262892-n38r8n70 156 3 LIFESTYLE lifestyle NN cord-262892-n38r8n70 156 4 [ [ -LRB- cord-262892-n38r8n70 156 5 50 50 CD cord-262892-n38r8n70 156 6 ] ] -RRB- cord-262892-n38r8n70 156 7 , , , cord-262892-n38r8n70 156 8 full full JJ cord-262892-n38r8n70 156 9 - - HYPH cord-262892-n38r8n70 156 10 dose dose NN cord-262892-n38r8n70 156 11 ritonavir ritonavir NNS cord-262892-n38r8n70 156 12 [ [ -LRB- cord-262892-n38r8n70 156 13 53 53 CD cord-262892-n38r8n70 156 14 ] ] -RRB- cord-262892-n38r8n70 156 15 , , , cord-262892-n38r8n70 156 16 and and CC cord-262892-n38r8n70 156 17 tenofovir tenofovir NNPS cord-262892-n38r8n70 156 18 [ [ -LRB- cord-262892-n38r8n70 156 19 54 54 CD cord-262892-n38r8n70 156 20 ] ] -RRB- cord-262892-n38r8n70 156 21 are be VBP cord-262892-n38r8n70 156 22 associated associate VBN cord-262892-n38r8n70 156 23 with with IN cord-262892-n38r8n70 156 24 lower low JJR cord-262892-n38r8n70 156 25 BMD bmd NN cord-262892-n38r8n70 156 26 in in IN cord-262892-n38r8n70 156 27 children child NNS cord-262892-n38r8n70 156 28 . . . cord-262892-n38r8n70 157 1 The the DT cord-262892-n38r8n70 157 2 principles principle NNS cord-262892-n38r8n70 157 3 of of IN cord-262892-n38r8n70 157 4 maintaining maintain VBG cord-262892-n38r8n70 157 5 good good JJ cord-262892-n38r8n70 157 6 bone bone NN cord-262892-n38r8n70 157 7 health health NN cord-262892-n38r8n70 157 8 in in IN cord-262892-n38r8n70 157 9 youth youth NN cord-262892-n38r8n70 157 10 with with IN cord-262892-n38r8n70 157 11 perinatal perinatal JJ cord-262892-n38r8n70 157 12 HIV HIV NNP cord-262892-n38r8n70 157 13 infection infection NN cord-262892-n38r8n70 157 14 is be VBZ cord-262892-n38r8n70 157 15 the the DT cord-262892-n38r8n70 157 16 same same JJ cord-262892-n38r8n70 157 17 as as IN cord-262892-n38r8n70 157 18 those those DT cord-262892-n38r8n70 157 19 recommended recommend VBN cord-262892-n38r8n70 157 20 for for IN cord-262892-n38r8n70 157 21 all all DT cord-262892-n38r8n70 157 22 youth youth NN cord-262892-n38r8n70 157 23 in in IN cord-262892-n38r8n70 157 24 general general JJ cord-262892-n38r8n70 157 25 . . . cord-262892-n38r8n70 158 1 Adolescents adolescent NNS cord-262892-n38r8n70 158 2 should should MD cord-262892-n38r8n70 158 3 therefore therefore RB cord-262892-n38r8n70 158 4 receive receive VB cord-262892-n38r8n70 158 5 at at IN cord-262892-n38r8n70 158 6 least least JJS cord-262892-n38r8n70 158 7 1,300 1,300 CD cord-262892-n38r8n70 158 8 mg mg NNP cord-262892-n38r8n70 158 9 calcium calcium NN cord-262892-n38r8n70 158 10 per per IN cord-262892-n38r8n70 158 11 day day NN cord-262892-n38r8n70 158 12 and and CC cord-262892-n38r8n70 158 13 at at RB cord-262892-n38r8n70 158 14 least least JJS cord-262892-n38r8n70 158 15 600 600 CD cord-262892-n38r8n70 158 16 IU IU NNP cord-262892-n38r8n70 158 17 vitamin vitamin NN cord-262892-n38r8n70 158 18 D d NN cord-262892-n38r8n70 158 19 per per IN cord-262892-n38r8n70 158 20 day day NN cord-262892-n38r8n70 158 21 through through IN cord-262892-n38r8n70 158 22 their -PRON- PRP$ cord-262892-n38r8n70 158 23 diet diet NN cord-262892-n38r8n70 158 24 , , , cord-262892-n38r8n70 158 25 by by IN cord-262892-n38r8n70 158 26 supplementation supplementation NN cord-262892-n38r8n70 158 27 , , , cord-262892-n38r8n70 158 28 or or CC cord-262892-n38r8n70 158 29 both both DT cord-262892-n38r8n70 158 30 [ [ -LRB- cord-262892-n38r8n70 158 31 55 55 CD cord-262892-n38r8n70 158 32 ] ] -RRB- cord-262892-n38r8n70 158 33 . . . cord-262892-n38r8n70 159 1 Immune immune JJ cord-262892-n38r8n70 159 2 reconstitution reconstitution NN cord-262892-n38r8n70 159 3 inflammatory inflammatory JJ cord-262892-n38r8n70 159 4 syndrome syndrome NN cord-262892-n38r8n70 159 5 ( ( -LRB- cord-262892-n38r8n70 159 6 IRIS IRIS NNP cord-262892-n38r8n70 159 7 ) ) -RRB- cord-262892-n38r8n70 159 8 is be VBZ cord-262892-n38r8n70 159 9 a a DT cord-262892-n38r8n70 159 10 diseasespecific diseasespecific JJ cord-262892-n38r8n70 159 11 inflammatory inflammatory JJ cord-262892-n38r8n70 159 12 response response NN cord-262892-n38r8n70 159 13 that that WDT cord-262892-n38r8n70 159 14 can can MD cord-262892-n38r8n70 159 15 occur occur VB cord-262892-n38r8n70 159 16 after after IN cord-262892-n38r8n70 159 17 treatment treatment NN cord-262892-n38r8n70 159 18 with with IN cord-262892-n38r8n70 159 19 ARVs arv NNS cord-262892-n38r8n70 159 20 is be VBZ cord-262892-n38r8n70 159 21 initiated initiate VBN cord-262892-n38r8n70 159 22 , , , cord-262892-n38r8n70 159 23 reinitiated reinitiate VBN cord-262892-n38r8n70 159 24 , , , cord-262892-n38r8n70 159 25 or or CC cord-262892-n38r8n70 159 26 changed change VBN cord-262892-n38r8n70 159 27 , , , cord-262892-n38r8n70 159 28 resulting result VBG cord-262892-n38r8n70 159 29 in in IN cord-262892-n38r8n70 159 30 effective effective JJ cord-262892-n38r8n70 159 31 virologic virologic JJ cord-262892-n38r8n70 159 32 suppression suppression NN cord-262892-n38r8n70 159 33 and and CC cord-262892-n38r8n70 159 34 immune immune JJ cord-262892-n38r8n70 159 35 reconstitution reconstitution NN cord-262892-n38r8n70 159 36 of of IN cord-262892-n38r8n70 159 37 naïve naïve JJ cord-262892-n38r8n70 159 38 and and CC cord-262892-n38r8n70 159 39 memory memory NN cord-262892-n38r8n70 159 40 CD4 CD4 NNP cord-262892-n38r8n70 159 41 + + CC cord-262892-n38r8n70 159 42 T t NN cord-262892-n38r8n70 159 43 cells cell NNS cord-262892-n38r8n70 159 44 . . . cord-262892-n38r8n70 160 1 IRIS IRIS NNP cord-262892-n38r8n70 160 2 has have VBZ cord-262892-n38r8n70 160 3 been be VBN cord-262892-n38r8n70 160 4 noted note VBN cord-262892-n38r8n70 160 5 to to TO cord-262892-n38r8n70 160 6 occur occur VB cord-262892-n38r8n70 160 7 in in IN cord-262892-n38r8n70 160 8 children child NNS cord-262892-n38r8n70 160 9 who who WP cord-262892-n38r8n70 160 10 begin begin VBP cord-262892-n38r8n70 160 11 ART art NN cord-262892-n38r8n70 160 12 while while IN cord-262892-n38r8n70 160 13 they -PRON- PRP cord-262892-n38r8n70 160 14 have have VBP cord-262892-n38r8n70 160 15 severe severe JJ cord-262892-n38r8n70 160 16 malnutrition malnutrition NN cord-262892-n38r8n70 160 17 , , , cord-262892-n38r8n70 160 18 are be VBP cord-262892-n38r8n70 160 19 severely severely RB cord-262892-n38r8n70 160 20 immunosuppressed immunosuppressed JJ cord-262892-n38r8n70 160 21 [ [ -LRB- cord-262892-n38r8n70 160 22 56 56 CD cord-262892-n38r8n70 160 23 ] ] -RRB- cord-262892-n38r8n70 160 24 , , , cord-262892-n38r8n70 160 25 or or CC cord-262892-n38r8n70 160 26 both both DT cord-262892-n38r8n70 160 27 . . . cord-262892-n38r8n70 161 1 Risk risk NN cord-262892-n38r8n70 161 2 factors factor NNS cord-262892-n38r8n70 161 3 therefore therefore RB cord-262892-n38r8n70 161 4 include include VBP cord-262892-n38r8n70 161 5 a a DT cord-262892-n38r8n70 161 6 low low JJ cord-262892-n38r8n70 161 7 CD4 CD4 NNP cord-262892-n38r8n70 161 8 nadir nadir NN cord-262892-n38r8n70 161 9 and and CC cord-262892-n38r8n70 161 10 high high JJ cord-262892-n38r8n70 161 11 viral viral JJ cord-262892-n38r8n70 161 12 load load NN cord-262892-n38r8n70 161 13 levels level NNS cord-262892-n38r8n70 161 14 prior prior RB cord-262892-n38r8n70 161 15 to to IN cord-262892-n38r8n70 161 16 the the DT cord-262892-n38r8n70 161 17 initiation initiation NN cord-262892-n38r8n70 161 18 of of IN cord-262892-n38r8n70 161 19 cART cART NNP cord-262892-n38r8n70 161 20 . . . cord-262892-n38r8n70 162 1 These these DT cord-262892-n38r8n70 162 2 children child NNS cord-262892-n38r8n70 162 3 and and CC cord-262892-n38r8n70 162 4 adolescents adolescent NNS cord-262892-n38r8n70 162 5 often often RB cord-262892-n38r8n70 162 6 have have VBP cord-262892-n38r8n70 162 7 numerous numerous JJ cord-262892-n38r8n70 162 8 documented document VBN cord-262892-n38r8n70 162 9 OIs ois NN cord-262892-n38r8n70 162 10 before before RB cord-262892-n38r8n70 162 11 , , , cord-262892-n38r8n70 162 12 during during IN cord-262892-n38r8n70 162 13 , , , cord-262892-n38r8n70 162 14 and and CC cord-262892-n38r8n70 162 15 after after IN cord-262892-n38r8n70 162 16 cART cART NNP cord-262892-n38r8n70 162 17 initiation initiation NNP cord-262892-n38r8n70 162 18 [ [ -LRB- cord-262892-n38r8n70 162 19 56 56 CD cord-262892-n38r8n70 162 20 ] ] -RRB- cord-262892-n38r8n70 162 21 . . . cord-262892-n38r8n70 163 1 Further further JJ cord-262892-n38r8n70 163 2 research research NN cord-262892-n38r8n70 163 3 is be VBZ cord-262892-n38r8n70 163 4 needed need VBN cord-262892-n38r8n70 163 5 to to TO cord-262892-n38r8n70 163 6 reduce reduce VB cord-262892-n38r8n70 163 7 complications complication NNS cord-262892-n38r8n70 163 8 and and CC cord-262892-n38r8n70 163 9 to to TO cord-262892-n38r8n70 163 10 optimize optimize VB cord-262892-n38r8n70 163 11 clinical clinical JJ cord-262892-n38r8n70 163 12 management management NN cord-262892-n38r8n70 163 13 when when WRB cord-262892-n38r8n70 163 14 they -PRON- PRP cord-262892-n38r8n70 163 15 do do VBP cord-262892-n38r8n70 163 16 occur occur VB cord-262892-n38r8n70 163 17 . . . cord-262892-n38r8n70 164 1 The the DT cord-262892-n38r8n70 164 2 interaction interaction NN cord-262892-n38r8n70 164 3 between between IN cord-262892-n38r8n70 164 4 HIV HIV NNP cord-262892-n38r8n70 164 5 infection infection NN cord-262892-n38r8n70 164 6 and and CC cord-262892-n38r8n70 164 7 nutrition nutrition NN cord-262892-n38r8n70 164 8 is be VBZ cord-262892-n38r8n70 164 9 of of IN cord-262892-n38r8n70 164 10 great great JJ cord-262892-n38r8n70 164 11 importance importance NN cord-262892-n38r8n70 164 12 , , , cord-262892-n38r8n70 164 13 and and CC cord-262892-n38r8n70 164 14 these these DT cord-262892-n38r8n70 164 15 two two CD cord-262892-n38r8n70 164 16 factors factor NNS cord-262892-n38r8n70 164 17 are be VBP cord-262892-n38r8n70 164 18 interdependent interdependent JJ cord-262892-n38r8n70 164 19 , , , cord-262892-n38r8n70 164 20 since since IN cord-262892-n38r8n70 164 21 strategies strategy NNS cord-262892-n38r8n70 164 22 to to TO cord-262892-n38r8n70 164 23 improve improve VB cord-262892-n38r8n70 164 24 nutritional nutritional JJ cord-262892-n38r8n70 164 25 status status NN cord-262892-n38r8n70 164 26 both both CC cord-262892-n38r8n70 164 27 quantitatively quantitatively RB cord-262892-n38r8n70 164 28 and and CC cord-262892-n38r8n70 164 29 qualitatively qualitatively RB cord-262892-n38r8n70 164 30 have have VBP cord-262892-n38r8n70 164 31 been be VBN cord-262892-n38r8n70 164 32 demonstrated demonstrate VBN cord-262892-n38r8n70 164 33 to to TO cord-262892-n38r8n70 164 34 have have VB cord-262892-n38r8n70 164 35 a a DT cord-262892-n38r8n70 164 36 beneficial beneficial JJ cord-262892-n38r8n70 164 37 effect effect NN cord-262892-n38r8n70 164 38 on on IN cord-262892-n38r8n70 164 39 clinical clinical JJ cord-262892-n38r8n70 164 40 outcome outcome NN cord-262892-n38r8n70 164 41 and and CC cord-262892-n38r8n70 164 42 the the DT cord-262892-n38r8n70 164 43 immunologic immunologic JJ cord-262892-n38r8n70 164 44 course course NN cord-262892-n38r8n70 164 45 of of IN cord-262892-n38r8n70 164 46 the the DT cord-262892-n38r8n70 164 47 HIV HIV NNP cord-262892-n38r8n70 164 48 infection infection NN cord-262892-n38r8n70 164 49 . . . cord-262892-n38r8n70 165 1 Through through IN cord-262892-n38r8n70 165 2 the the DT cord-262892-n38r8n70 165 3 course course NN cord-262892-n38r8n70 165 4 of of IN cord-262892-n38r8n70 165 5 their -PRON- PRP$ cord-262892-n38r8n70 165 6 disease disease NN cord-262892-n38r8n70 165 7 , , , cord-262892-n38r8n70 165 8 infants infant NNS cord-262892-n38r8n70 165 9 and and CC cord-262892-n38r8n70 165 10 children child NNS cord-262892-n38r8n70 165 11 with with IN cord-262892-n38r8n70 165 12 HIV HIV NNP cord-262892-n38r8n70 165 13 have have VBP cord-262892-n38r8n70 165 14 numerous numerous JJ cord-262892-n38r8n70 165 15 nutritional nutritional JJ cord-262892-n38r8n70 165 16 needs need NNS cord-262892-n38r8n70 165 17 , , , cord-262892-n38r8n70 165 18 which which WDT cord-262892-n38r8n70 165 19 reflects reflect VBZ cord-262892-n38r8n70 165 20 , , , cord-262892-n38r8n70 165 21 as as IN cord-262892-n38r8n70 165 22 previously previously RB cord-262892-n38r8n70 165 23 described describe VBN cord-262892-n38r8n70 165 24 , , , cord-262892-n38r8n70 165 25 impaired impaired JJ cord-262892-n38r8n70 165 26 absorption absorption NN cord-262892-n38r8n70 165 27 , , , cord-262892-n38r8n70 165 28 decreased decrease VBD cord-262892-n38r8n70 165 29 oral oral JJ cord-262892-n38r8n70 165 30 intake intake NN cord-262892-n38r8n70 165 31 , , , cord-262892-n38r8n70 165 32 and and CC cord-262892-n38r8n70 165 33 increased increase VBN cord-262892-n38r8n70 165 34 nutrient nutrient NN cord-262892-n38r8n70 165 35 requirements requirement NNS cord-262892-n38r8n70 165 36 . . . cord-262892-n38r8n70 166 1 Specific specific JJ cord-262892-n38r8n70 166 2 adverse adverse JJ cord-262892-n38r8n70 166 3 outcomes outcome NNS cord-262892-n38r8n70 166 4 secondary secondary JJ cord-262892-n38r8n70 166 5 to to IN cord-262892-n38r8n70 166 6 specific specific JJ cord-262892-n38r8n70 166 7 nutritional nutritional JJ cord-262892-n38r8n70 166 8 deficiencies deficiency NNS cord-262892-n38r8n70 166 9 include include VBP cord-262892-n38r8n70 166 10 the the DT cord-262892-n38r8n70 166 11 inability inability NN cord-262892-n38r8n70 166 12 to to TO cord-262892-n38r8n70 166 13 achieve achieve VB cord-262892-n38r8n70 166 14 normal normal JJ cord-262892-n38r8n70 166 15 weight weight NN cord-262892-n38r8n70 166 16 for for IN cord-262892-n38r8n70 166 17 height height NN cord-262892-n38r8n70 166 18 ; ; : cord-262892-n38r8n70 166 19 malnutrition malnutrition NN cord-262892-n38r8n70 166 20 and and CC cord-262892-n38r8n70 166 21 wasting wasting NN cord-262892-n38r8n70 166 22 ; ; : cord-262892-n38r8n70 166 23 growth growth NN cord-262892-n38r8n70 166 24 failure failure NN cord-262892-n38r8n70 166 25 and and CC cord-262892-n38r8n70 166 26 stunting stunting NN cord-262892-n38r8n70 166 27 ; ; : cord-262892-n38r8n70 166 28 and and CC cord-262892-n38r8n70 166 29 neurocognitive neurocognitive NNS cord-262892-n38r8n70 166 30 , , , cord-262892-n38r8n70 166 31 neurodevelopmental neurodevelopmental JJ cord-262892-n38r8n70 166 32 , , , cord-262892-n38r8n70 166 33 and and CC cord-262892-n38r8n70 166 34 oral oral JJ cord-262892-n38r8n70 166 35 motor motor NN cord-262892-n38r8n70 166 36 delay delay NN cord-262892-n38r8n70 166 37 often often RB cord-262892-n38r8n70 166 38 from from IN cord-262892-n38r8n70 166 39 HIV HIV NNP cord-262892-n38r8n70 166 40 encephalopathy encephalopathy NN cord-262892-n38r8n70 166 41 . . . cord-262892-n38r8n70 167 1 Early early JJ cord-262892-n38r8n70 167 2 nutrition nutrition NN cord-262892-n38r8n70 167 3 intervention intervention NN cord-262892-n38r8n70 167 4 is be VBZ cord-262892-n38r8n70 167 5 , , , cord-262892-n38r8n70 167 6 therefore therefore RB cord-262892-n38r8n70 167 7 , , , cord-262892-n38r8n70 167 8 essential essential JJ cord-262892-n38r8n70 167 9 and and CC cord-262892-n38r8n70 167 10 must must MD cord-262892-n38r8n70 167 11 be be VB cord-262892-n38r8n70 167 12 addressed address VBN cord-262892-n38r8n70 167 13 simultaneously simultaneously RB cord-262892-n38r8n70 167 14 with with IN cord-262892-n38r8n70 167 15 the the DT cord-262892-n38r8n70 167 16 administration administration NN cord-262892-n38r8n70 167 17 of of IN cord-262892-n38r8n70 167 18 cART cART NNP cord-262892-n38r8n70 167 19 , , , cord-262892-n38r8n70 167 20 antimicrobial antimicrobial JJ cord-262892-n38r8n70 167 21 prophylaxis prophylaxis NN cord-262892-n38r8n70 167 22 , , , cord-262892-n38r8n70 167 23 and and CC cord-262892-n38r8n70 167 24 neurodevelopmental neurodevelopmental JJ cord-262892-n38r8n70 167 25 interventions intervention NNS cord-262892-n38r8n70 167 26 . . . cord-262892-n38r8n70 168 1 Collectively collectively RB cord-262892-n38r8n70 168 2 , , , cord-262892-n38r8n70 168 3 a a DT cord-262892-n38r8n70 168 4 II ii NN cord-262892-n38r8n70 168 5 . . . cord-262892-n38r8n70 169 1 NUTRITION NUTRITION NNP cord-262892-n38r8n70 169 2 AND and CC cord-262892-n38r8n70 169 3 LIFESTYLE lifestyle NN cord-262892-n38r8n70 169 4 multidisciplinary multidisciplinary JJ cord-262892-n38r8n70 169 5 approach approach NN cord-262892-n38r8n70 169 6 is be VBZ cord-262892-n38r8n70 169 7 most most RBS cord-262892-n38r8n70 169 8 effective effective JJ cord-262892-n38r8n70 169 9 in in IN cord-262892-n38r8n70 169 10 improving improve VBG cord-262892-n38r8n70 169 11 health health NN cord-262892-n38r8n70 169 12 outcomes outcome NNS cord-262892-n38r8n70 169 13 and and CC cord-262892-n38r8n70 169 14 overall overall JJ cord-262892-n38r8n70 169 15 quality quality NN cord-262892-n38r8n70 169 16 of of IN cord-262892-n38r8n70 169 17 life life NN cord-262892-n38r8n70 169 18 . . . cord-262892-n38r8n70 170 1 In in IN cord-262892-n38r8n70 170 2 the the DT cord-262892-n38r8n70 170 3 pre pre JJ cord-262892-n38r8n70 170 4 - - JJ cord-262892-n38r8n70 170 5 cART cart JJ cord-262892-n38r8n70 170 6 era era NN cord-262892-n38r8n70 170 7 , , , cord-262892-n38r8n70 170 8 the the DT cord-262892-n38r8n70 170 9 nutritional nutritional JJ cord-262892-n38r8n70 170 10 causes cause NNS cord-262892-n38r8n70 170 11 of of IN cord-262892-n38r8n70 170 12 malnutrition malnutrition NN cord-262892-n38r8n70 170 13 reflected reflect VBN cord-262892-n38r8n70 170 14 ( ( -LRB- cord-262892-n38r8n70 170 15 1 1 CD cord-262892-n38r8n70 170 16 ) ) -RRB- cord-262892-n38r8n70 170 17 decreased decrease VBD cord-262892-n38r8n70 170 18 oral oral JJ cord-262892-n38r8n70 170 19 intake intake NN cord-262892-n38r8n70 170 20 caused cause VBN cord-262892-n38r8n70 170 21 by by IN cord-262892-n38r8n70 170 22 anorexia anorexia NN cord-262892-n38r8n70 170 23 and and CC cord-262892-n38r8n70 170 24 by by IN cord-262892-n38r8n70 170 25 oral oral JJ cord-262892-n38r8n70 170 26 and and CC cord-262892-n38r8n70 170 27 esophageal esophageal JJ cord-262892-n38r8n70 170 28 lesions lesion NNS cord-262892-n38r8n70 170 29 often often RB cord-262892-n38r8n70 170 30 from from IN cord-262892-n38r8n70 170 31 opportunistic opportunistic JJ cord-262892-n38r8n70 170 32 pathogens pathogen NNS cord-262892-n38r8n70 170 33 , , , cord-262892-n38r8n70 170 34 ( ( -LRB- cord-262892-n38r8n70 170 35 2 2 LS cord-262892-n38r8n70 170 36 ) ) -RRB- cord-262892-n38r8n70 170 37 gastroesophageal gastroesophageal JJ cord-262892-n38r8n70 170 38 reflux reflux NN cord-262892-n38r8n70 170 39 and and CC cord-262892-n38r8n70 170 40 aspiration aspiration NN cord-262892-n38r8n70 170 41 , , , cord-262892-n38r8n70 170 42 ( ( -LRB- cord-262892-n38r8n70 170 43 3 3 LS cord-262892-n38r8n70 170 44 ) ) -RRB- cord-262892-n38r8n70 170 45 regression regression NN cord-262892-n38r8n70 170 46 or or CC cord-262892-n38r8n70 170 47 nonattainment nonattainment NN cord-262892-n38r8n70 170 48 of of IN cord-262892-n38r8n70 170 49 key key JJ cord-262892-n38r8n70 170 50 developmental developmental JJ cord-262892-n38r8n70 170 51 milestones milestone NNS cord-262892-n38r8n70 170 52 associated associate VBN cord-262892-n38r8n70 170 53 with with IN cord-262892-n38r8n70 170 54 oromotor oromotor NN cord-262892-n38r8n70 170 55 dysfunction dysfunction NN cord-262892-n38r8n70 170 56 and and CC cord-262892-n38r8n70 170 57 impaired impair VBN cord-262892-n38r8n70 170 58 mastication mastication NN cord-262892-n38r8n70 170 59 , , , cord-262892-n38r8n70 171 1 ( ( -LRB- cord-262892-n38r8n70 171 2 4 4 LS cord-262892-n38r8n70 171 3 ) ) -RRB- cord-262892-n38r8n70 171 4 malabsorption malabsorption NN cord-262892-n38r8n70 171 5 , , , cord-262892-n38r8n70 171 6 ( ( -LRB- cord-262892-n38r8n70 171 7 5 5 LS cord-262892-n38r8n70 171 8 ) ) -RRB- cord-262892-n38r8n70 171 9 increased increase VBN cord-262892-n38r8n70 171 10 energy energy NN cord-262892-n38r8n70 171 11 requirements requirement NNS cord-262892-n38r8n70 171 12 and and CC cord-262892-n38r8n70 171 13 metabolism metabolism NN cord-262892-n38r8n70 171 14 from from IN cord-262892-n38r8n70 171 15 OIs OIs NNP cord-262892-n38r8n70 171 16 with with IN cord-262892-n38r8n70 171 17 associated associated JJ cord-262892-n38r8n70 171 18 negative negative JJ cord-262892-n38r8n70 171 19 energy energy NN cord-262892-n38r8n70 171 20 balance balance NN cord-262892-n38r8n70 171 21 , , , cord-262892-n38r8n70 171 22 ( ( -LRB- cord-262892-n38r8n70 171 23 6 6 LS cord-262892-n38r8n70 171 24 ) ) -RRB- cord-262892-n38r8n70 171 25 vomiting vomiting NN cord-262892-n38r8n70 171 26 and and CC cord-262892-n38r8n70 171 27 diarrhea diarrhea NN cord-262892-n38r8n70 171 28 from from IN cord-262892-n38r8n70 171 29 gastrointestinal gastrointestinal JJ cord-262892-n38r8n70 171 30 ( ( -LRB- cord-262892-n38r8n70 171 31 opportunistic opportunistic JJ cord-262892-n38r8n70 171 32 ) ) -RRB- cord-262892-n38r8n70 171 33 enteropathogens enteropathogen NNS cord-262892-n38r8n70 171 34 , , , cord-262892-n38r8n70 171 35 and and CC cord-262892-n38r8n70 171 36 ( ( -LRB- cord-262892-n38r8n70 171 37 7 7 CD cord-262892-n38r8n70 171 38 ) ) -RRB- cord-262892-n38r8n70 171 39 indirect indirect JJ cord-262892-n38r8n70 171 40 immune immune NN cord-262892-n38r8n70 171 41 - - HYPH cord-262892-n38r8n70 171 42 mediated mediate VBN cord-262892-n38r8n70 171 43 enteropathy enteropathy NN cord-262892-n38r8n70 171 44 . . . cord-262892-n38r8n70 172 1 At at IN cord-262892-n38r8n70 172 2 a a DT cord-262892-n38r8n70 172 3 time time NN cord-262892-n38r8n70 172 4 when when WRB cord-262892-n38r8n70 172 5 effective effective JJ cord-262892-n38r8n70 172 6 cART cART NNP cord-262892-n38r8n70 172 7 was be VBD cord-262892-n38r8n70 172 8 unavailable unavailable JJ cord-262892-n38r8n70 172 9 and and CC cord-262892-n38r8n70 172 10 faced face VBN cord-262892-n38r8n70 172 11 with with IN cord-262892-n38r8n70 172 12 a a DT cord-262892-n38r8n70 172 13 debilitating debilitating JJ cord-262892-n38r8n70 172 14 catabolic catabolic JJ cord-262892-n38r8n70 172 15 disease disease NN cord-262892-n38r8n70 172 16 and and CC cord-262892-n38r8n70 172 17 rapid rapid JJ cord-262892-n38r8n70 172 18 disease disease NN cord-262892-n38r8n70 172 19 progression progression NN cord-262892-n38r8n70 172 20 in in IN cord-262892-n38r8n70 172 21 infants infant NNS cord-262892-n38r8n70 172 22 and and CC cord-262892-n38r8n70 172 23 children child NNS cord-262892-n38r8n70 172 24 with with IN cord-262892-n38r8n70 172 25 HIV HIV NNP cord-262892-n38r8n70 172 26 , , , cord-262892-n38r8n70 172 27 nutritional nutritional JJ cord-262892-n38r8n70 172 28 interventions intervention NNS cord-262892-n38r8n70 172 29 that that WDT cord-262892-n38r8n70 172 30 were be VBD cord-262892-n38r8n70 172 31 developed develop VBN cord-262892-n38r8n70 172 32 in in IN cord-262892-n38r8n70 172 33 the the DT cord-262892-n38r8n70 172 34 early early JJ cord-262892-n38r8n70 172 35 1990s 1990 NNS cord-262892-n38r8n70 172 36 by by IN cord-262892-n38r8n70 172 37 pediatric pediatric JJ cord-262892-n38r8n70 172 38 providers provider NNS cord-262892-n38r8n70 172 39 targeted target VBD cord-262892-n38r8n70 172 40 four four CD cord-262892-n38r8n70 172 41 key key JJ cord-262892-n38r8n70 172 42 areas area NNS cord-262892-n38r8n70 172 43 : : : cord-262892-n38r8n70 173 1 1 1 LS cord-262892-n38r8n70 173 2 . . . cord-262892-n38r8n70 174 1 Prompt prompt JJ cord-262892-n38r8n70 174 2 management management NN cord-262892-n38r8n70 174 3 of of IN cord-262892-n38r8n70 174 4 diarrhea diarrhea NN cord-262892-n38r8n70 174 5 . . . cord-262892-n38r8n70 175 1 In in IN cord-262892-n38r8n70 175 2 addition addition NN cord-262892-n38r8n70 175 3 to to IN cord-262892-n38r8n70 175 4 isolation isolation NN cord-262892-n38r8n70 175 5 of of IN cord-262892-n38r8n70 175 6 opportunistic opportunistic JJ cord-262892-n38r8n70 175 7 enteropathogens enteropathogen NNS cord-262892-n38r8n70 175 8 and and CC cord-262892-n38r8n70 175 9 prescribing prescribe VBG cord-262892-n38r8n70 175 10 appropriate appropriate JJ cord-262892-n38r8n70 175 11 antimicrobials antimicrobial NNS cord-262892-n38r8n70 175 12 for for IN cord-262892-n38r8n70 175 13 infectious infectious JJ cord-262892-n38r8n70 175 14 etiologies etiology NNS cord-262892-n38r8n70 175 15 , , , cord-262892-n38r8n70 175 16 management management NN cord-262892-n38r8n70 175 17 of of IN cord-262892-n38r8n70 175 18 diarrhea diarrhea NN cord-262892-n38r8n70 175 19 mandates mandate NNS cord-262892-n38r8n70 175 20 assessment assessment NN cord-262892-n38r8n70 175 21 of of IN cord-262892-n38r8n70 175 22 hydration hydration NN cord-262892-n38r8n70 175 23 status status NN cord-262892-n38r8n70 175 24 and and CC cord-262892-n38r8n70 175 25 rehydration rehydration NN cord-262892-n38r8n70 175 26 by by IN cord-262892-n38r8n70 175 27 the the DT cord-262892-n38r8n70 175 28 oral oral JJ cord-262892-n38r8n70 175 29 or or CC cord-262892-n38r8n70 175 30 intravenous intravenous JJ cord-262892-n38r8n70 175 31 route route NN cord-262892-n38r8n70 175 32 . . . cord-262892-n38r8n70 176 1 Modification modification NN cord-262892-n38r8n70 176 2 of of IN cord-262892-n38r8n70 176 3 diet diet NN cord-262892-n38r8n70 176 4 in in IN cord-262892-n38r8n70 176 5 the the DT cord-262892-n38r8n70 176 6 setting setting NN cord-262892-n38r8n70 176 7 of of IN cord-262892-n38r8n70 176 8 underlying underlie VBG cord-262892-n38r8n70 176 9 food food NN cord-262892-n38r8n70 176 10 intolerance intolerance NN cord-262892-n38r8n70 176 11 such such JJ cord-262892-n38r8n70 176 12 as as IN cord-262892-n38r8n70 176 13 lactose lactose NN cord-262892-n38r8n70 176 14 or or CC cord-262892-n38r8n70 176 15 fat fat JJ cord-262892-n38r8n70 176 16 malabsorption malabsorption NN cord-262892-n38r8n70 176 17 , , , cord-262892-n38r8n70 176 18 including include VBG cord-262892-n38r8n70 176 19 pancreatic pancreatic JJ cord-262892-n38r8n70 176 20 enzyme enzyme NN cord-262892-n38r8n70 176 21 supplementation supplementation NN cord-262892-n38r8n70 176 22 ; ; , cord-262892-n38r8n70 176 23 and and CC cord-262892-n38r8n70 176 24 vitamin vitamin NN cord-262892-n38r8n70 176 25 and and CC cord-262892-n38r8n70 176 26 mineral mineral NN cord-262892-n38r8n70 176 27 supplementation supplementation NN cord-262892-n38r8n70 176 28 . . . cord-262892-n38r8n70 177 1 other other JJ cord-262892-n38r8n70 177 2 recommendations recommendation NNS cord-262892-n38r8n70 177 3 included include VBD cord-262892-n38r8n70 177 4 introduction introduction NN cord-262892-n38r8n70 177 5 of of IN cord-262892-n38r8n70 177 6 a a DT cord-262892-n38r8n70 177 7 mechanical mechanical JJ cord-262892-n38r8n70 177 8 soft soft JJ cord-262892-n38r8n70 177 9 diet diet NN cord-262892-n38r8n70 177 10 and and CC cord-262892-n38r8n70 177 11 nutritional nutritional JJ cord-262892-n38r8n70 177 12 supplementation supplementation NN cord-262892-n38r8n70 177 13 . . . cord-262892-n38r8n70 178 1 4 4 LS cord-262892-n38r8n70 178 2 . . . cord-262892-n38r8n70 179 1 Management management NN cord-262892-n38r8n70 179 2 of of IN cord-262892-n38r8n70 179 3 nausea nausea NN cord-262892-n38r8n70 179 4 and and CC cord-262892-n38r8n70 179 5 vomiting vomiting NN cord-262892-n38r8n70 179 6 . . . cord-262892-n38r8n70 180 1 In in IN cord-262892-n38r8n70 180 2 addition addition NN cord-262892-n38r8n70 180 3 to to IN cord-262892-n38r8n70 180 4 appropriate appropriate JJ cord-262892-n38r8n70 180 5 antiemetic antiemetic JJ cord-262892-n38r8n70 180 6 agents agent NNS cord-262892-n38r8n70 180 7 , , , cord-262892-n38r8n70 180 8 treatment treatment NN cord-262892-n38r8n70 180 9 also also RB cord-262892-n38r8n70 180 10 included include VBD cord-262892-n38r8n70 180 11 recommendation recommendation NN cord-262892-n38r8n70 180 12 of of IN cord-262892-n38r8n70 180 13 small small JJ cord-262892-n38r8n70 180 14 frequent frequent JJ cord-262892-n38r8n70 180 15 meals meal NNS cord-262892-n38r8n70 180 16 , , , cord-262892-n38r8n70 180 17 liquid liquid JJ cord-262892-n38r8n70 180 18 intakes intake NNS cord-262892-n38r8n70 180 19 between between IN cord-262892-n38r8n70 180 20 meals meal NNS cord-262892-n38r8n70 180 21 , , , cord-262892-n38r8n70 180 22 and and CC cord-262892-n38r8n70 180 23 nutritional nutritional JJ cord-262892-n38r8n70 180 24 supplementation supplementation NN cord-262892-n38r8n70 180 25 . . . cord-262892-n38r8n70 181 1 5 5 LS cord-262892-n38r8n70 181 2 . . . cord-262892-n38r8n70 182 1 Management management NN cord-262892-n38r8n70 182 2 of of IN cord-262892-n38r8n70 182 3 anorexia anorexia NN cord-262892-n38r8n70 182 4 included include VBD cord-262892-n38r8n70 182 5 small small JJ cord-262892-n38r8n70 182 6 nutrient nutrient NN cord-262892-n38r8n70 182 7 dense dense JJ cord-262892-n38r8n70 182 8 foods food NNS cord-262892-n38r8n70 182 9 , , , cord-262892-n38r8n70 182 10 nutritional nutritional JJ cord-262892-n38r8n70 182 11 supplementation supplementation NN cord-262892-n38r8n70 182 12 , , , cord-262892-n38r8n70 182 13 and and CC cord-262892-n38r8n70 182 14 appetite appetite NN cord-262892-n38r8n70 182 15 stimulants stimulant NNS cord-262892-n38r8n70 182 16 such such JJ cord-262892-n38r8n70 182 17 as as IN cord-262892-n38r8n70 182 18 megestrol megestrol NN cord-262892-n38r8n70 182 19 acetate acetate NN cord-262892-n38r8n70 182 20 . . . cord-262892-n38r8n70 183 1 These these DT cord-262892-n38r8n70 183 2 early early JJ cord-262892-n38r8n70 183 3 nutrition nutrition NN cord-262892-n38r8n70 183 4 needs need VBZ cord-262892-n38r8n70 183 5 related relate VBN cord-262892-n38r8n70 183 6 to to IN cord-262892-n38r8n70 183 7 the the DT cord-262892-n38r8n70 183 8 unique unique JJ cord-262892-n38r8n70 183 9 physiologic physiologic JJ cord-262892-n38r8n70 183 10 demands demand NNS cord-262892-n38r8n70 183 11 for for IN cord-262892-n38r8n70 183 12 growth growth NN cord-262892-n38r8n70 183 13 and and CC cord-262892-n38r8n70 183 14 development development NN cord-262892-n38r8n70 183 15 , , , cord-262892-n38r8n70 183 16 so so RB cord-262892-n38r8n70 183 17 even even RB cord-262892-n38r8n70 183 18 today today NN cord-262892-n38r8n70 183 19 , , , cord-262892-n38r8n70 183 20 interventions intervention NNS cord-262892-n38r8n70 183 21 should should MD cord-262892-n38r8n70 183 22 be be VB cord-262892-n38r8n70 183 23 individualized individualize VBN cord-262892-n38r8n70 183 24 according accord VBG cord-262892-n38r8n70 183 25 to to IN cord-262892-n38r8n70 183 26 the the DT cord-262892-n38r8n70 183 27 child child NN cord-262892-n38r8n70 183 28 's 's POS cord-262892-n38r8n70 183 29 specific specific JJ cord-262892-n38r8n70 183 30 needs need NNS cord-262892-n38r8n70 183 31 and and CC cord-262892-n38r8n70 183 32 relate relate VBP cord-262892-n38r8n70 183 33 to to IN cord-262892-n38r8n70 183 34 disease disease NN cord-262892-n38r8n70 183 35 stage stage NN cord-262892-n38r8n70 183 36 , , , cord-262892-n38r8n70 183 37 gastrointestinal gastrointestinal JJ cord-262892-n38r8n70 183 38 function function NN cord-262892-n38r8n70 183 39 , , , cord-262892-n38r8n70 183 40 and and CC cord-262892-n38r8n70 183 41 growth growth NN cord-262892-n38r8n70 183 42 [ [ -LRB- cord-262892-n38r8n70 183 43 57 57 CD cord-262892-n38r8n70 183 44 ] ] -RRB- cord-262892-n38r8n70 183 45 . . . cord-262892-n38r8n70 184 1 As as IN cord-262892-n38r8n70 184 2 a a DT cord-262892-n38r8n70 184 3 corollary corollary NN cord-262892-n38r8n70 184 4 , , , cord-262892-n38r8n70 184 5 the the DT cord-262892-n38r8n70 184 6 energy energy NN cord-262892-n38r8n70 184 7 and and CC cord-262892-n38r8n70 184 8 protein protein NN cord-262892-n38r8n70 184 9 requirements requirement NNS cord-262892-n38r8n70 184 10 for for IN cord-262892-n38r8n70 184 11 infants infant NNS cord-262892-n38r8n70 184 12 and and CC cord-262892-n38r8n70 184 13 children child NNS cord-262892-n38r8n70 184 14 with with IN cord-262892-n38r8n70 184 15 HIV HIV NNP cord-262892-n38r8n70 184 16 have have VBP cord-262892-n38r8n70 184 17 not not RB cord-262892-n38r8n70 184 18 yet yet RB cord-262892-n38r8n70 184 19 been be VBN cord-262892-n38r8n70 184 20 established establish VBN cord-262892-n38r8n70 184 21 because because IN cord-262892-n38r8n70 184 22 individual individual JJ cord-262892-n38r8n70 184 23 needs need NNS cord-262892-n38r8n70 184 24 vary vary VBP cord-262892-n38r8n70 184 25 , , , cord-262892-n38r8n70 184 26 depending depend VBG cord-262892-n38r8n70 184 27 on on IN cord-262892-n38r8n70 184 28 age age NN cord-262892-n38r8n70 184 29 , , , cord-262892-n38r8n70 184 30 growth growth NN cord-262892-n38r8n70 184 31 , , , cord-262892-n38r8n70 184 32 and and CC cord-262892-n38r8n70 184 33 the the DT cord-262892-n38r8n70 184 34 clinical clinical JJ cord-262892-n38r8n70 184 35 and and CC cord-262892-n38r8n70 184 36 immunologic immunologic JJ cord-262892-n38r8n70 184 37 status status NN cord-262892-n38r8n70 184 38 that that WDT cord-262892-n38r8n70 184 39 may may MD cord-262892-n38r8n70 184 40 increase increase VB cord-262892-n38r8n70 184 41 energy energy NN cord-262892-n38r8n70 184 42 and and CC cord-262892-n38r8n70 184 43 protein protein NN cord-262892-n38r8n70 184 44 needs need NNS cord-262892-n38r8n70 184 45 . . . cord-262892-n38r8n70 185 1 Infants infant NNS cord-262892-n38r8n70 185 2 and and CC cord-262892-n38r8n70 185 3 children child NNS cord-262892-n38r8n70 185 4 with with IN cord-262892-n38r8n70 185 5 HIV HIV NNP cord-262892-n38r8n70 185 6 who who WP cord-262892-n38r8n70 185 7 have have VBP cord-262892-n38r8n70 185 8 slow slow JJ cord-262892-n38r8n70 185 9 weight weight NN cord-262892-n38r8n70 185 10 gain gain NN cord-262892-n38r8n70 185 11 are be VBP cord-262892-n38r8n70 185 12 often often RB cord-262892-n38r8n70 185 13 prescribed prescribe VBN cord-262892-n38r8n70 185 14 high high JJ cord-262892-n38r8n70 185 15 - - HYPH cord-262892-n38r8n70 185 16 protein protein NN cord-262892-n38r8n70 185 17 , , , cord-262892-n38r8n70 185 18 high high JJ cord-262892-n38r8n70 185 19 - - HYPH cord-262892-n38r8n70 185 20 calorie calorie NN cord-262892-n38r8n70 185 21 diets diet NNS cord-262892-n38r8n70 185 22 . . . cord-262892-n38r8n70 186 1 If if IN cord-262892-n38r8n70 186 2 nutritional nutritional JJ cord-262892-n38r8n70 186 3 needs need NNS cord-262892-n38r8n70 186 4 are be VBP cord-262892-n38r8n70 186 5 not not RB cord-262892-n38r8n70 186 6 met meet VBN cord-262892-n38r8n70 186 7 through through IN cord-262892-n38r8n70 186 8 a a DT cord-262892-n38r8n70 186 9 typical typical JJ cord-262892-n38r8n70 186 10 high high JJ cord-262892-n38r8n70 186 11 - - HYPH cord-262892-n38r8n70 186 12 calorie calorie NN cord-262892-n38r8n70 186 13 , , , cord-262892-n38r8n70 186 14 high high JJ cord-262892-n38r8n70 186 15 - - HYPH cord-262892-n38r8n70 186 16 protein protein NN cord-262892-n38r8n70 186 17 diet diet NN cord-262892-n38r8n70 186 18 , , , cord-262892-n38r8n70 186 19 then then RB cord-262892-n38r8n70 186 20 additional additional JJ cord-262892-n38r8n70 186 21 support support NN cord-262892-n38r8n70 186 22 may may MD cord-262892-n38r8n70 186 23 include include VB cord-262892-n38r8n70 186 24 oral oral JJ cord-262892-n38r8n70 186 25 nutritional nutritional JJ cord-262892-n38r8n70 186 26 supplements supplement NNS cord-262892-n38r8n70 186 27 and and CC cord-262892-n38r8n70 186 28 overnight overnight JJ cord-262892-n38r8n70 186 29 feeding feed VBG cord-262892-n38r8n70 186 30 through through IN cord-262892-n38r8n70 186 31 nasogastric nasogastric NN cord-262892-n38r8n70 186 32 or or CC cord-262892-n38r8n70 186 33 gastrostomy gastrostomy NN cord-262892-n38r8n70 186 34 - - HYPH cord-262892-n38r8n70 186 35 tube tube NN cord-262892-n38r8n70 186 36 feedings feeding NNS cord-262892-n38r8n70 186 37 . . . cord-262892-n38r8n70 187 1 A a DT cord-262892-n38r8n70 187 2 commercial commercial JJ cord-262892-n38r8n70 187 3 formula formula NN cord-262892-n38r8n70 187 4 with with IN cord-262892-n38r8n70 187 5 intact intact JJ cord-262892-n38r8n70 187 6 protein protein NN cord-262892-n38r8n70 187 7 may may MD cord-262892-n38r8n70 187 8 be be VB cord-262892-n38r8n70 187 9 appropriate appropriate JJ cord-262892-n38r8n70 187 10 for for IN cord-262892-n38r8n70 187 11 children child NNS cord-262892-n38r8n70 187 12 without without IN cord-262892-n38r8n70 187 13 underlying underlie VBG cord-262892-n38r8n70 187 14 gastrointestinal gastrointestinal JJ cord-262892-n38r8n70 187 15 pathology pathology NN cord-262892-n38r8n70 187 16 . . . cord-262892-n38r8n70 188 1 Infants infant NNS cord-262892-n38r8n70 188 2 and and CC cord-262892-n38r8n70 188 3 children child NNS cord-262892-n38r8n70 188 4 with with IN cord-262892-n38r8n70 188 5 HIV HIV NNP cord-262892-n38r8n70 188 6 who who WP cord-262892-n38r8n70 188 7 have have VBP cord-262892-n38r8n70 188 8 gastrointestinal gastrointestinal JJ cord-262892-n38r8n70 188 9 malabsorption malabsorption NN cord-262892-n38r8n70 188 10 should should MD cord-262892-n38r8n70 188 11 receive receive VB cord-262892-n38r8n70 188 12 a a DT cord-262892-n38r8n70 188 13 semi semi JJ cord-262892-n38r8n70 188 14 - - JJ cord-262892-n38r8n70 188 15 elemental elemental JJ cord-262892-n38r8n70 188 16 formula formula NN cord-262892-n38r8n70 188 17 to to TO cord-262892-n38r8n70 188 18 maximize maximize VB cord-262892-n38r8n70 188 19 absorption absorption NN cord-262892-n38r8n70 188 20 . . . cord-262892-n38r8n70 189 1 Elemental elemental JJ cord-262892-n38r8n70 189 2 formulas formula NNS cord-262892-n38r8n70 189 3 are be VBP cord-262892-n38r8n70 189 4 typically typically RB cord-262892-n38r8n70 189 5 prescribed prescribe VBN cord-262892-n38r8n70 189 6 when when WRB cord-262892-n38r8n70 189 7 semi semi JJ cord-262892-n38r8n70 189 8 - - JJ cord-262892-n38r8n70 189 9 elemental elemental JJ cord-262892-n38r8n70 189 10 formulas formula NNS cord-262892-n38r8n70 189 11 are be VBP cord-262892-n38r8n70 189 12 not not RB cord-262892-n38r8n70 189 13 tolerated tolerate VBN cord-262892-n38r8n70 189 14 . . . cord-262892-n38r8n70 190 1 Infants infant NNS cord-262892-n38r8n70 190 2 and and CC cord-262892-n38r8n70 190 3 children child NNS cord-262892-n38r8n70 190 4 with with IN cord-262892-n38r8n70 190 5 HIV HIV NNP cord-262892-n38r8n70 190 6 who who WP cord-262892-n38r8n70 190 7 are be VBP cord-262892-n38r8n70 190 8 unable unable JJ cord-262892-n38r8n70 190 9 to to TO cord-262892-n38r8n70 190 10 consume consume VB cord-262892-n38r8n70 190 11 adequate adequate JJ cord-262892-n38r8n70 190 12 calories calorie NNS cord-262892-n38r8n70 190 13 orally orally RB cord-262892-n38r8n70 190 14 often often RB cord-262892-n38r8n70 190 15 benefit benefit VBP cord-262892-n38r8n70 190 16 from from IN cord-262892-n38r8n70 190 17 supplemental supplemental JJ cord-262892-n38r8n70 190 18 tube tube NN cord-262892-n38r8n70 190 19 feeding feeding NN cord-262892-n38r8n70 190 20 . . . cord-262892-n38r8n70 191 1 Enteral enteral NN cord-262892-n38r8n70 191 2 tube tube NN cord-262892-n38r8n70 191 3 feeding feeding NN cord-262892-n38r8n70 191 4 supplementation supplementation NN cord-262892-n38r8n70 191 5 improves improve VBZ cord-262892-n38r8n70 191 6 weight weight NN cord-262892-n38r8n70 191 7 gain gain NN cord-262892-n38r8n70 191 8 in in IN cord-262892-n38r8n70 191 9 children child NNS cord-262892-n38r8n70 191 10 with with IN cord-262892-n38r8n70 191 11 HIV HIV NNP cord-262892-n38r8n70 191 12 who who WP cord-262892-n38r8n70 191 13 have have VBP cord-262892-n38r8n70 191 14 growth growth NN cord-262892-n38r8n70 191 15 failure failure NN cord-262892-n38r8n70 191 16 [ [ -LRB- cord-262892-n38r8n70 191 17 37 37 CD cord-262892-n38r8n70 191 18 , , , cord-262892-n38r8n70 191 19 38 38 CD cord-262892-n38r8n70 191 20 ] ] -RRB- cord-262892-n38r8n70 191 21 . . . cord-262892-n38r8n70 192 1 Nasogastric nasogastric NN cord-262892-n38r8n70 192 2 tube tube NN cord-262892-n38r8n70 192 3 feedings feeding NNS cord-262892-n38r8n70 192 4 should should MD cord-262892-n38r8n70 192 5 be be VB cord-262892-n38r8n70 192 6 initially initially RB cord-262892-n38r8n70 192 7 attempted attempt VBN cord-262892-n38r8n70 192 8 and and CC cord-262892-n38r8n70 192 9 include include VBP cord-262892-n38r8n70 192 10 night night NN cord-262892-n38r8n70 192 11 - - HYPH cord-262892-n38r8n70 192 12 time time NN cord-262892-n38r8n70 192 13 feedings feeding NNS cord-262892-n38r8n70 192 14 , , , cord-262892-n38r8n70 192 15 which which WDT cord-262892-n38r8n70 192 16 allow allow VBP cord-262892-n38r8n70 192 17 the the DT cord-262892-n38r8n70 192 18 child child NN cord-262892-n38r8n70 192 19 to to TO cord-262892-n38r8n70 192 20 eat eat VB cord-262892-n38r8n70 192 21 normally normally RB cord-262892-n38r8n70 192 22 throughout throughout IN cord-262892-n38r8n70 192 23 the the DT cord-262892-n38r8n70 192 24 day day NN cord-262892-n38r8n70 192 25 . . . cord-262892-n38r8n70 193 1 Complications complication NNS cord-262892-n38r8n70 193 2 relating relate VBG cord-262892-n38r8n70 193 3 to to IN cord-262892-n38r8n70 193 4 nasogastric nasogastric NN cord-262892-n38r8n70 193 5 tube tube NN cord-262892-n38r8n70 193 6 feedings feeding NNS cord-262892-n38r8n70 193 7 include include VBP cord-262892-n38r8n70 193 8 sinusitis sinusitis NN cord-262892-n38r8n70 193 9 and and CC cord-262892-n38r8n70 193 10 the the DT cord-262892-n38r8n70 193 11 technical technical JJ cord-262892-n38r8n70 193 12 inability inability NN cord-262892-n38r8n70 193 13 of of IN cord-262892-n38r8n70 193 14 the the DT cord-262892-n38r8n70 193 15 caregiver caregiver NN cord-262892-n38r8n70 193 16 to to TO cord-262892-n38r8n70 193 17 place place VB cord-262892-n38r8n70 193 18 the the DT cord-262892-n38r8n70 193 19 tube tube NN cord-262892-n38r8n70 193 20 or or CC cord-262892-n38r8n70 193 21 administer administer VB cord-262892-n38r8n70 193 22 the the DT cord-262892-n38r8n70 193 23 feedings feeding NNS cord-262892-n38r8n70 193 24 [ [ -LRB- cord-262892-n38r8n70 193 25 21 21 CD cord-262892-n38r8n70 193 26 ] ] -RRB- cord-262892-n38r8n70 193 27 . . . cord-262892-n38r8n70 194 1 If if IN cord-262892-n38r8n70 194 2 delivery delivery NN cord-262892-n38r8n70 194 3 of of IN cord-262892-n38r8n70 194 4 feedings feeding NNS cord-262892-n38r8n70 194 5 through through IN cord-262892-n38r8n70 194 6 a a DT cord-262892-n38r8n70 194 7 nasogastric nasogastric NN cord-262892-n38r8n70 194 8 tube tube NN cord-262892-n38r8n70 194 9 improves improve VBZ cord-262892-n38r8n70 194 10 growth growth NN cord-262892-n38r8n70 194 11 , , , cord-262892-n38r8n70 194 12 then then RB cord-262892-n38r8n70 194 13 placement placement NN cord-262892-n38r8n70 194 14 of of IN cord-262892-n38r8n70 194 15 a a DT cord-262892-n38r8n70 194 16 more more RBR cord-262892-n38r8n70 194 17 permanent permanent JJ cord-262892-n38r8n70 194 18 device device NN cord-262892-n38r8n70 194 19 such such JJ cord-262892-n38r8n70 194 20 as as IN cord-262892-n38r8n70 194 21 a a DT cord-262892-n38r8n70 194 22 gastrostomy gastrostomy NN cord-262892-n38r8n70 194 23 tube tube NN cord-262892-n38r8n70 194 24 should should MD cord-262892-n38r8n70 194 25 be be VB cord-262892-n38r8n70 194 26 considered consider VBN cord-262892-n38r8n70 194 27 . . . cord-262892-n38r8n70 195 1 Enteral enteral JJ cord-262892-n38r8n70 195 2 supplementation supplementation NN cord-262892-n38r8n70 195 3 with with IN cord-262892-n38r8n70 195 4 gastrostomy gastrostomy NN cord-262892-n38r8n70 195 5 feeding feeding NN cord-262892-n38r8n70 195 6 has have VBZ cord-262892-n38r8n70 195 7 improved improve VBN cord-262892-n38r8n70 195 8 nutrition nutrition NN cord-262892-n38r8n70 195 9 in in IN cord-262892-n38r8n70 195 10 a a DT cord-262892-n38r8n70 195 11 number number NN cord-262892-n38r8n70 195 12 of of IN cord-262892-n38r8n70 195 13 chronic chronic JJ cord-262892-n38r8n70 195 14 childhood childhood NN cord-262892-n38r8n70 195 15 illnesses illness NNS cord-262892-n38r8n70 195 16 by by IN cord-262892-n38r8n70 195 17 providing provide VBG cord-262892-n38r8n70 195 18 adequate adequate JJ cord-262892-n38r8n70 195 19 energy energy NN cord-262892-n38r8n70 195 20 intake intake NN cord-262892-n38r8n70 195 21 to to TO cord-262892-n38r8n70 195 22 promote promote VB cord-262892-n38r8n70 195 23 weight weight NN cord-262892-n38r8n70 195 24 gain gain NN cord-262892-n38r8n70 195 25 when when WRB cord-262892-n38r8n70 195 26 oral oral JJ cord-262892-n38r8n70 195 27 intake intake NN cord-262892-n38r8n70 195 28 is be VBZ cord-262892-n38r8n70 195 29 poor poor JJ cord-262892-n38r8n70 195 30 . . . cord-262892-n38r8n70 196 1 Miller Miller NNP cord-262892-n38r8n70 196 2 et et NNP cord-262892-n38r8n70 196 3 al al NNP cord-262892-n38r8n70 196 4 . . . cord-262892-n38r8n70 197 1 [ [ -LRB- cord-262892-n38r8n70 197 2 37 37 CD cord-262892-n38r8n70 197 3 ] ] -RRB- cord-262892-n38r8n70 197 4 first first RB cord-262892-n38r8n70 197 5 investigated investigate VBD cord-262892-n38r8n70 197 6 the the DT cord-262892-n38r8n70 197 7 effects effect NNS cord-262892-n38r8n70 197 8 of of IN cord-262892-n38r8n70 197 9 gastrostomy gastrostomy NN cord-262892-n38r8n70 197 10 tube tube NN cord-262892-n38r8n70 197 11 feeding feed VBG cord-262892-n38r8n70 197 12 on on IN cord-262892-n38r8n70 197 13 weight weight NN cord-262892-n38r8n70 197 14 gain gain NN cord-262892-n38r8n70 197 15 , , , cord-262892-n38r8n70 197 16 height height NN cord-262892-n38r8n70 197 17 , , , cord-262892-n38r8n70 197 18 body body NN cord-262892-n38r8n70 197 19 composition composition NN cord-262892-n38r8n70 197 20 , , , cord-262892-n38r8n70 197 21 immune immune JJ cord-262892-n38r8n70 197 22 parameters parameter NNS cord-262892-n38r8n70 197 23 , , , cord-262892-n38r8n70 197 24 morbidity morbidity NN cord-262892-n38r8n70 197 25 , , , cord-262892-n38r8n70 197 26 and and CC cord-262892-n38r8n70 197 27 mortality mortality NN cord-262892-n38r8n70 197 28 in in IN cord-262892-n38r8n70 197 29 1995 1995 CD cord-262892-n38r8n70 197 30 on on IN cord-262892-n38r8n70 197 31 26 26 CD cord-262892-n38r8n70 197 32 children child NNS cord-262892-n38r8n70 197 33 with with IN cord-262892-n38r8n70 197 34 HIV HIV NNP cord-262892-n38r8n70 197 35 . . . cord-262892-n38r8n70 198 1 Weight Weight NNP cord-262892-n38r8n70 198 2 Z z NN cord-262892-n38r8n70 198 3 - - HYPH cord-262892-n38r8n70 198 4 scores score NNS cord-262892-n38r8n70 198 5 before before IN cord-262892-n38r8n70 198 6 therapy therapy NN cord-262892-n38r8n70 198 7 were be VBD cord-262892-n38r8n70 198 8 -1.6 -1.6 NNPS cord-262892-n38r8n70 198 9 and and CC cord-262892-n38r8n70 198 10 had have VBD cord-262892-n38r8n70 198 11 decreased decrease VBN cord-262892-n38r8n70 198 12 to to IN cord-262892-n38r8n70 198 13 -2.2 -2.2 CD cord-262892-n38r8n70 198 14 on on IN cord-262892-n38r8n70 198 15 initiation initiation NN cord-262892-n38r8n70 198 16 of of IN cord-262892-n38r8n70 198 17 nasogastric nasogastric NN cord-262892-n38r8n70 198 18 feedings feeding NNS cord-262892-n38r8n70 198 19 . . . cord-262892-n38r8n70 199 1 Gastrostomy Gastrostomy NNP cord-262892-n38r8n70 199 2 tube tube NN cord-262892-n38r8n70 199 3 feedings feeding NNS cord-262892-n38r8n70 199 4 significantly significantly RB cord-262892-n38r8n70 199 5 improved improve VBD cord-262892-n38r8n70 199 6 weight weight NN cord-262892-n38r8n70 199 7 Z z NN cord-262892-n38r8n70 199 8 - - HYPH cord-262892-n38r8n70 199 9 scores score NNS cord-262892-n38r8n70 199 10 to to TO cord-262892-n38r8n70 199 11 get get VB cord-262892-n38r8n70 199 12 back back RB cord-262892-n38r8n70 199 13 to to IN cord-262892-n38r8n70 199 14 baseline baseline NN cord-262892-n38r8n70 199 15 approximately approximately RB cord-262892-n38r8n70 199 16 5 5 CD cord-262892-n38r8n70 199 17 months month NNS cord-262892-n38r8n70 199 18 after after IN cord-262892-n38r8n70 199 19 initiation initiation NN cord-262892-n38r8n70 199 20 of of IN cord-262892-n38r8n70 199 21 feeding feeding NN cord-262892-n38r8n70 199 22 . . . cord-262892-n38r8n70 200 1 Significant significant JJ cord-262892-n38r8n70 200 2 predictors predictor NNS cord-262892-n38r8n70 200 3 of of IN cord-262892-n38r8n70 200 4 response response NN cord-262892-n38r8n70 200 5 to to IN cord-262892-n38r8n70 200 6 gastrostomy gastrostomy NN cord-262892-n38r8n70 200 7 tube tube NN cord-262892-n38r8n70 200 8 feedings feeding NNS cord-262892-n38r8n70 200 9 included include VBD cord-262892-n38r8n70 200 10 higher high JJR cord-262892-n38r8n70 200 11 CD4 CD4 NNP cord-262892-n38r8n70 200 12 counts count VBZ cord-262892-n38r8n70 200 13 at at IN cord-262892-n38r8n70 200 14 initiation initiation NN cord-262892-n38r8n70 200 15 and and CC cord-262892-n38r8n70 200 16 lower low JJR cord-262892-n38r8n70 200 17 weight weight NN cord-262892-n38r8n70 200 18 - - HYPH cord-262892-n38r8n70 200 19 for for IN cord-262892-n38r8n70 200 20 - - HYPH cord-262892-n38r8n70 200 21 height height NN cord-262892-n38r8n70 200 22 Z z NN cord-262892-n38r8n70 200 23 - - HYPH cord-262892-n38r8n70 200 24 scores score NNS cord-262892-n38r8n70 200 25 at at IN cord-262892-n38r8n70 200 26 baseline baseline NN cord-262892-n38r8n70 200 27 . . . cord-262892-n38r8n70 201 1 These these DT cord-262892-n38r8n70 201 2 findings finding NNS cord-262892-n38r8n70 201 3 suggested suggest VBD cord-262892-n38r8n70 201 4 that that IN cord-262892-n38r8n70 201 5 early early JJ cord-262892-n38r8n70 201 6 intervention intervention NN cord-262892-n38r8n70 201 7 during during IN cord-262892-n38r8n70 201 8 acute acute JJ cord-262892-n38r8n70 201 9 weight weight NN cord-262892-n38r8n70 201 10 loss loss NN cord-262892-n38r8n70 201 11 offers offer VBZ cord-262892-n38r8n70 201 12 the the DT cord-262892-n38r8n70 201 13 best good JJS cord-262892-n38r8n70 201 14 chances chance NNS cord-262892-n38r8n70 201 15 of of IN cord-262892-n38r8n70 201 16 improving improve VBG cord-262892-n38r8n70 201 17 weight weight NN cord-262892-n38r8n70 201 18 in in IN cord-262892-n38r8n70 201 19 children child NNS cord-262892-n38r8n70 201 20 with with IN cord-262892-n38r8n70 201 21 HIV HIV NNP cord-262892-n38r8n70 201 22 . . . cord-262892-n38r8n70 202 1 Children child NNS cord-262892-n38r8n70 202 2 with with IN cord-262892-n38r8n70 202 3 the the DT cord-262892-n38r8n70 202 4 greatest great JJS cord-262892-n38r8n70 202 5 improvement improvement NN cord-262892-n38r8n70 202 6 in in IN cord-262892-n38r8n70 202 7 weight weight NN cord-262892-n38r8n70 202 8 after after IN cord-262892-n38r8n70 202 9 gastrostomy gastrostomy NN cord-262892-n38r8n70 202 10 tube tube NN cord-262892-n38r8n70 202 11 placement placement NN cord-262892-n38r8n70 202 12 spent spend VBN cord-262892-n38r8n70 202 13 less less JJR cord-262892-n38r8n70 202 14 time time NN cord-262892-n38r8n70 202 15 in in IN cord-262892-n38r8n70 202 16 hospital hospital NN cord-262892-n38r8n70 202 17 and and CC cord-262892-n38r8n70 202 18 had have VBD cord-262892-n38r8n70 202 19 a a DT cord-262892-n38r8n70 202 20 greater great JJR cord-262892-n38r8n70 202 21 likelihood likelihood NN cord-262892-n38r8n70 202 22 of of IN cord-262892-n38r8n70 202 23 survival survival NN cord-262892-n38r8n70 202 24 compared compare VBN cord-262892-n38r8n70 202 25 with with IN cord-262892-n38r8n70 202 26 children child NNS cord-262892-n38r8n70 202 27 who who WP cord-262892-n38r8n70 202 28 did do VBD cord-262892-n38r8n70 202 29 not not RB cord-262892-n38r8n70 202 30 gain gain VB cord-262892-n38r8n70 202 31 weight weight NN cord-262892-n38r8n70 202 32 [ [ -LRB- cord-262892-n38r8n70 202 33 37 37 CD cord-262892-n38r8n70 202 34 ] ] -RRB- cord-262892-n38r8n70 202 35 . . . cord-262892-n38r8n70 203 1 This this DT cord-262892-n38r8n70 203 2 small small JJ cord-262892-n38r8n70 203 3 but but CC cord-262892-n38r8n70 203 4 important important JJ cord-262892-n38r8n70 203 5 study study NN cord-262892-n38r8n70 203 6 demonstrated demonstrate VBD cord-262892-n38r8n70 203 7 that that IN cord-262892-n38r8n70 203 8 early early JJ cord-262892-n38r8n70 203 9 nutritional nutritional JJ cord-262892-n38r8n70 203 10 intervention intervention NN cord-262892-n38r8n70 203 11 improved improve VBD cord-262892-n38r8n70 203 12 quality quality NN cord-262892-n38r8n70 203 13 of of IN cord-262892-n38r8n70 203 14 life life NN cord-262892-n38r8n70 203 15 and and CC cord-262892-n38r8n70 203 16 reduced reduce VBN cord-262892-n38r8n70 203 17 morbidity morbidity NN cord-262892-n38r8n70 203 18 in in IN cord-262892-n38r8n70 203 19 children child NNS cord-262892-n38r8n70 203 20 with with IN cord-262892-n38r8n70 203 21 HIV HIV NNP cord-262892-n38r8n70 203 22 at at IN cord-262892-n38r8n70 203 23 a a DT cord-262892-n38r8n70 203 24 time time NN cord-262892-n38r8n70 203 25 when when WRB cord-262892-n38r8n70 203 26 effective effective JJ cord-262892-n38r8n70 203 27 cART cART NNP cord-262892-n38r8n70 203 28 was be VBD cord-262892-n38r8n70 203 29 unavailable unavailable JJ cord-262892-n38r8n70 203 30 . . . cord-262892-n38r8n70 204 1 In in IN cord-262892-n38r8n70 204 2 the the DT cord-262892-n38r8n70 204 3 cART cart JJ cord-262892-n38r8n70 204 4 era era NN cord-262892-n38r8n70 204 5 , , , cord-262892-n38r8n70 204 6 compliance compliance NN cord-262892-n38r8n70 204 7 with with IN cord-262892-n38r8n70 204 8 medical medical JJ cord-262892-n38r8n70 204 9 therapy therapy NN cord-262892-n38r8n70 204 10 is be VBZ cord-262892-n38r8n70 204 11 often often RB cord-262892-n38r8n70 204 12 improved improve VBN cord-262892-n38r8n70 204 13 with with IN cord-262892-n38r8n70 204 14 more more RBR cord-262892-n38r8n70 204 15 reliable reliable JJ cord-262892-n38r8n70 204 16 delivery delivery NN cord-262892-n38r8n70 204 17 of of IN cord-262892-n38r8n70 204 18 ARVs arv NNS cord-262892-n38r8n70 204 19 through through IN cord-262892-n38r8n70 204 20 the the DT cord-262892-n38r8n70 204 21 gastrostomy gastrostomy NN cord-262892-n38r8n70 204 22 tube tube NN cord-262892-n38r8n70 204 23 and and CC cord-262892-n38r8n70 204 24 is be VBZ cord-262892-n38r8n70 204 25 associated associate VBN cord-262892-n38r8n70 204 26 with with IN cord-262892-n38r8n70 204 27 improved improved JJ cord-262892-n38r8n70 204 28 CD4 CD4 NNP cord-262892-n38r8n70 204 29 T T NNP cord-262892-n38r8n70 204 30 - - HYPH cord-262892-n38r8n70 204 31 lymphocyte lymphocyte NN cord-262892-n38r8n70 204 32 counts count NNS cord-262892-n38r8n70 204 33 , , , cord-262892-n38r8n70 204 34 virologic virologic NNP cord-262892-n38r8n70 204 35 suppression suppression NN cord-262892-n38r8n70 204 36 , , , cord-262892-n38r8n70 204 37 and and CC cord-262892-n38r8n70 204 38 improved improve VBN cord-262892-n38r8n70 204 39 longitudinal longitudinal JJ cord-262892-n38r8n70 204 40 growth growth NN cord-262892-n38r8n70 204 41 . . . cord-262892-n38r8n70 205 1 Guarino Guarino NNP cord-262892-n38r8n70 205 2 et et NNP cord-262892-n38r8n70 205 3 al al NNP cord-262892-n38r8n70 205 4 . . . cord-262892-n38r8n70 206 1 tested test VBD cord-262892-n38r8n70 206 2 the the DT cord-262892-n38r8n70 206 3 hypothesis hypothesis NN cord-262892-n38r8n70 206 4 that that IN cord-262892-n38r8n70 206 5 nutritional nutritional JJ cord-262892-n38r8n70 206 6 support support NN cord-262892-n38r8n70 206 7 improves improve VBZ cord-262892-n38r8n70 206 8 intestinal intestinal JJ cord-262892-n38r8n70 206 9 and and CC cord-262892-n38r8n70 206 10 immune immune JJ cord-262892-n38r8n70 206 11 functions function NNS cord-262892-n38r8n70 206 12 in in IN cord-262892-n38r8n70 206 13 62 62 CD cord-262892-n38r8n70 206 14 Italian italian JJ cord-262892-n38r8n70 206 15 children child NNS cord-262892-n38r8n70 206 16 with with IN cord-262892-n38r8n70 206 17 HIV HIV NNP cord-262892-n38r8n70 206 18 ; ; : cord-262892-n38r8n70 206 19 16 16 CD cord-262892-n38r8n70 206 20 received receive VBD cord-262892-n38r8n70 206 21 enteral enteral JJ cord-262892-n38r8n70 206 22 nutrition nutrition NN cord-262892-n38r8n70 206 23 through through IN cord-262892-n38r8n70 206 24 continuous continuous JJ cord-262892-n38r8n70 206 25 feeding feeding NN cord-262892-n38r8n70 206 26 , , , cord-262892-n38r8n70 206 27 and and CC cord-262892-n38r8n70 206 28 46 46 CD cord-262892-n38r8n70 206 29 received receive VBD cord-262892-n38r8n70 206 30 total total JJ cord-262892-n38r8n70 206 31 parenteral parenteral JJ cord-262892-n38r8n70 206 32 nutrition nutrition NN cord-262892-n38r8n70 206 33 . . . cord-262892-n38r8n70 207 1 The the DT cord-262892-n38r8n70 207 2 authors author NNS cord-262892-n38r8n70 207 3 documented document VBD cord-262892-n38r8n70 207 4 a a DT cord-262892-n38r8n70 207 5 significant significant JJ cord-262892-n38r8n70 207 6 increase increase NN cord-262892-n38r8n70 207 7 in in IN cord-262892-n38r8n70 207 8 CD4 CD4 NNP cord-262892-n38r8n70 207 9 cell cell NN cord-262892-n38r8n70 207 10 count count NN cord-262892-n38r8n70 207 11 , , , cord-262892-n38r8n70 207 12 xylose xylose NN cord-262892-n38r8n70 207 13 levels level NNS cord-262892-n38r8n70 207 14 , , , cord-262892-n38r8n70 207 15 and and CC cord-262892-n38r8n70 207 16 body body NN cord-262892-n38r8n70 207 17 weight weight NN cord-262892-n38r8n70 207 18 in in IN cord-262892-n38r8n70 207 19 those those DT cord-262892-n38r8n70 207 20 receiving receive VBG cord-262892-n38r8n70 207 21 enteral enteral JJ cord-262892-n38r8n70 207 22 nutrition nutrition NN cord-262892-n38r8n70 207 23 , , , cord-262892-n38r8n70 207 24 suggesting suggest VBG cord-262892-n38r8n70 207 25 that that IN cord-262892-n38r8n70 207 26 nutritional nutritional JJ cord-262892-n38r8n70 207 27 intervention intervention NN cord-262892-n38r8n70 207 28 may may MD cord-262892-n38r8n70 207 29 restore restore VB cord-262892-n38r8n70 207 30 intestinal intestinal JJ cord-262892-n38r8n70 207 31 absorption absorption NN cord-262892-n38r8n70 207 32 and and CC cord-262892-n38r8n70 207 33 increase increase VB cord-262892-n38r8n70 207 34 CD4 CD4 NNP cord-262892-n38r8n70 207 35 cell cell NN cord-262892-n38r8n70 207 36 numbers number NNS cord-262892-n38r8n70 207 37 if if IN cord-262892-n38r8n70 207 38 initiated initiate VBN cord-262892-n38r8n70 207 39 early early RB cord-262892-n38r8n70 207 40 in in IN cord-262892-n38r8n70 207 41 the the DT cord-262892-n38r8n70 207 42 course course NN cord-262892-n38r8n70 207 43 of of IN cord-262892-n38r8n70 207 44 pediatric pediatric JJ cord-262892-n38r8n70 207 45 HIV HIV NNP cord-262892-n38r8n70 207 46 infection infection NN cord-262892-n38r8n70 207 47 [ [ -LRB- cord-262892-n38r8n70 207 48 58 58 CD cord-262892-n38r8n70 207 49 ] ] -RRB- cord-262892-n38r8n70 207 50 . . . cord-262892-n38r8n70 208 1 Enteral enteral JJ cord-262892-n38r8n70 208 2 feeding feeding NN cord-262892-n38r8n70 208 3 is be VBZ cord-262892-n38r8n70 208 4 preferred prefer VBN cord-262892-n38r8n70 208 5 over over IN cord-262892-n38r8n70 208 6 parenteral parenteral JJ cord-262892-n38r8n70 208 7 nutrition nutrition NN cord-262892-n38r8n70 208 8 to to TO cord-262892-n38r8n70 208 9 preserve preserve VB cord-262892-n38r8n70 208 10 the the DT cord-262892-n38r8n70 208 11 gut gut NN cord-262892-n38r8n70 208 12 structure structure NN cord-262892-n38r8n70 208 13 . . . cord-262892-n38r8n70 209 1 Parenteral parenteral JJ cord-262892-n38r8n70 209 2 nutrition nutrition NN cord-262892-n38r8n70 209 3 should should MD cord-262892-n38r8n70 209 4 be be VB cord-262892-n38r8n70 209 5 used use VBN cord-262892-n38r8n70 209 6 only only RB cord-262892-n38r8n70 209 7 in in IN cord-262892-n38r8n70 209 8 those those DT cord-262892-n38r8n70 209 9 children child NNS cord-262892-n38r8n70 209 10 unable unable JJ cord-262892-n38r8n70 209 11 to to TO cord-262892-n38r8n70 209 12 tolerate tolerate VB cord-262892-n38r8n70 209 13 or or CC cord-262892-n38r8n70 209 14 gain gain VB cord-262892-n38r8n70 209 15 weight weight NN cord-262892-n38r8n70 209 16 on on IN cord-262892-n38r8n70 209 17 enteral enteral JJ cord-262892-n38r8n70 209 18 supplementation supplementation NN cord-262892-n38r8n70 209 19 , , , cord-262892-n38r8n70 209 20 those those DT cord-262892-n38r8n70 209 21 who who WP cord-262892-n38r8n70 209 22 have have VBP cord-262892-n38r8n70 209 23 recurrent recurrent JJ cord-262892-n38r8n70 209 24 or or CC cord-262892-n38r8n70 209 25 chronic chronic JJ cord-262892-n38r8n70 209 26 biliary biliary JJ cord-262892-n38r8n70 209 27 tract tract NN cord-262892-n38r8n70 209 28 or or CC cord-262892-n38r8n70 209 29 pancreatic pancreatic JJ cord-262892-n38r8n70 209 30 disease disease NN cord-262892-n38r8n70 209 31 , , , cord-262892-n38r8n70 209 32 and and CC cord-262892-n38r8n70 209 33 those those DT cord-262892-n38r8n70 209 34 who who WP cord-262892-n38r8n70 209 35 have have VBP cord-262892-n38r8n70 209 36 intractable intractable JJ cord-262892-n38r8n70 209 37 diarrhea diarrhea NN cord-262892-n38r8n70 209 38 with with IN cord-262892-n38r8n70 209 39 weight weight NN cord-262892-n38r8n70 209 40 loss loss NN cord-262892-n38r8n70 209 41 [ [ -LRB- cord-262892-n38r8n70 209 42 21 21 CD cord-262892-n38r8n70 209 43 ] ] -RRB- cord-262892-n38r8n70 209 44 . . . cord-262892-n38r8n70 210 1 Megestrol megestrol IN cord-262892-n38r8n70 210 2 acetate acetate NN cord-262892-n38r8n70 210 3 is be VBZ cord-262892-n38r8n70 210 4 an an DT cord-262892-n38r8n70 210 5 oral oral JJ cord-262892-n38r8n70 210 6 synthetic synthetic JJ cord-262892-n38r8n70 210 7 progesterone progesterone NN cord-262892-n38r8n70 210 8 used use VBN cord-262892-n38r8n70 210 9 since since IN cord-262892-n38r8n70 210 10 the the DT cord-262892-n38r8n70 210 11 early early JJ cord-262892-n38r8n70 210 12 1990s 1990 NNS cord-262892-n38r8n70 210 13 as as IN cord-262892-n38r8n70 210 14 an an DT cord-262892-n38r8n70 210 15 appetite appetite NN cord-262892-n38r8n70 210 16 stimulant stimulant NN cord-262892-n38r8n70 210 17 . . . cord-262892-n38r8n70 211 1 Weight weight NN cord-262892-n38r8n70 211 2 gain gain NN cord-262892-n38r8n70 211 3 tends tend VBZ cord-262892-n38r8n70 211 4 to to TO cord-262892-n38r8n70 211 5 be be VB cord-262892-n38r8n70 211 6 associated associate VBN cord-262892-n38r8n70 211 7 with with IN cord-262892-n38r8n70 211 8 increase increase NN cord-262892-n38r8n70 211 9 in in IN cord-262892-n38r8n70 211 10 body body NN cord-262892-n38r8n70 211 11 fat fat NN cord-262892-n38r8n70 211 12 rather rather RB cord-262892-n38r8n70 211 13 than than IN cord-262892-n38r8n70 211 14 muscle muscle NN cord-262892-n38r8n70 211 15 . . . cord-262892-n38r8n70 212 1 Clarick Clarick NNP cord-262892-n38r8n70 212 2 et et NNP cord-262892-n38r8n70 212 3 al al NNP cord-262892-n38r8n70 212 4 . . NNP cord-262892-n38r8n70 212 5 investigated investigate VBD cord-262892-n38r8n70 212 6 the the DT cord-262892-n38r8n70 212 7 effects effect NNS cord-262892-n38r8n70 212 8 of of IN cord-262892-n38r8n70 212 9 megestrol megestrol NN cord-262892-n38r8n70 212 10 acetate acetate NN cord-262892-n38r8n70 212 11 treatment treatment NN cord-262892-n38r8n70 212 12 on on IN cord-262892-n38r8n70 212 13 weight weight NN cord-262892-n38r8n70 212 14 gain gain NN cord-262892-n38r8n70 212 15 and and CC cord-262892-n38r8n70 212 16 linear linear JJ cord-262892-n38r8n70 212 17 growth growth NN cord-262892-n38r8n70 212 18 in in IN cord-262892-n38r8n70 212 19 19 19 CD cord-262892-n38r8n70 212 20 children child NNS cord-262892-n38r8n70 212 21 with with IN cord-262892-n38r8n70 212 22 HIV HIV NNP cord-262892-n38r8n70 212 23 who who WP cord-262892-n38r8n70 212 24 had have VBD cord-262892-n38r8n70 212 25 growth growth NN cord-262892-n38r8n70 212 26 failure failure NN cord-262892-n38r8n70 212 27 . . . cord-262892-n38r8n70 213 1 The the DT cord-262892-n38r8n70 213 2 average average JJ cord-262892-n38r8n70 213 3 duration duration NN cord-262892-n38r8n70 213 4 of of IN cord-262892-n38r8n70 213 5 the the DT cord-262892-n38r8n70 213 6 study study NN cord-262892-n38r8n70 213 7 was be VBD cord-262892-n38r8n70 213 8 7 7 CD cord-262892-n38r8n70 213 9 months month NNS cord-262892-n38r8n70 213 10 . . . cord-262892-n38r8n70 214 1 The the DT cord-262892-n38r8n70 214 2 study study NN cord-262892-n38r8n70 214 3 concluded conclude VBD cord-262892-n38r8n70 214 4 that that IN cord-262892-n38r8n70 214 5 megestrol megestrol NN cord-262892-n38r8n70 214 6 acetate acetate NN cord-262892-n38r8n70 214 7 was be VBD cord-262892-n38r8n70 214 8 associated associate VBN cord-262892-n38r8n70 214 9 with with IN cord-262892-n38r8n70 214 10 weight weight NN cord-262892-n38r8n70 214 11 gain gain NN cord-262892-n38r8n70 214 12 but but CC cord-262892-n38r8n70 214 13 not not RB cord-262892-n38r8n70 214 14 linear linear JJ cord-262892-n38r8n70 214 15 growth growth NN cord-262892-n38r8n70 214 16 during during IN cord-262892-n38r8n70 214 17 the the DT cord-262892-n38r8n70 214 18 treatment treatment NN cord-262892-n38r8n70 214 19 period period NN cord-262892-n38r8n70 214 20 . . . cord-262892-n38r8n70 215 1 After after IN cord-262892-n38r8n70 215 2 the the DT cord-262892-n38r8n70 215 3 megestrol megestrol NN cord-262892-n38r8n70 215 4 acetate acetate NN cord-262892-n38r8n70 215 5 treatment treatment NN cord-262892-n38r8n70 215 6 was be VBD cord-262892-n38r8n70 215 7 discontinued discontinue VBN cord-262892-n38r8n70 215 8 , , , cord-262892-n38r8n70 215 9 poor poor JJ cord-262892-n38r8n70 215 10 weight weight NN cord-262892-n38r8n70 215 11 gain gain NN cord-262892-n38r8n70 215 12 and and CC cord-262892-n38r8n70 215 13 weight weight NN cord-262892-n38r8n70 215 14 loss loss NN cord-262892-n38r8n70 215 15 were be VBD cord-262892-n38r8n70 215 16 again again RB cord-262892-n38r8n70 215 17 noted note VBN cord-262892-n38r8n70 215 18 [ [ -LRB- cord-262892-n38r8n70 215 19 39 39 CD cord-262892-n38r8n70 215 20 ] ] -RRB- cord-262892-n38r8n70 215 21 . . . cord-262892-n38r8n70 216 1 Given give VBN cord-262892-n38r8n70 216 2 the the DT cord-262892-n38r8n70 216 3 dramatic dramatic JJ cord-262892-n38r8n70 216 4 reductions reduction NNS cord-262892-n38r8n70 216 5 in in IN cord-262892-n38r8n70 216 6 morbidity morbidity NN cord-262892-n38r8n70 216 7 and and CC cord-262892-n38r8n70 216 8 mortality mortality NN cord-262892-n38r8n70 216 9 and and CC cord-262892-n38r8n70 216 10 the the DT cord-262892-n38r8n70 216 11 improved improved JJ cord-262892-n38r8n70 216 12 longitudinal longitudinal JJ cord-262892-n38r8n70 216 13 growth growth NN cord-262892-n38r8n70 216 14 in in IN cord-262892-n38r8n70 216 15 children child NNS cord-262892-n38r8n70 216 16 with with IN cord-262892-n38r8n70 216 17 HIV HIV NNP cord-262892-n38r8n70 216 18 in in IN cord-262892-n38r8n70 216 19 the the DT cord-262892-n38r8n70 216 20 United United NNP cord-262892-n38r8n70 216 21 States States NNP cord-262892-n38r8n70 216 22 since since IN cord-262892-n38r8n70 216 23 the the DT cord-262892-n38r8n70 216 24 widespread widespread JJ cord-262892-n38r8n70 216 25 implementation implementation NN cord-262892-n38r8n70 216 26 of of IN cord-262892-n38r8n70 216 27 effective effective JJ cord-262892-n38r8n70 216 28 cART cART NNP cord-262892-n38r8n70 216 29 , , , cord-262892-n38r8n70 216 30 megestrol megestrol NN cord-262892-n38r8n70 216 31 acetate acetate NN cord-262892-n38r8n70 216 32 and and CC cord-262892-n38r8n70 216 33 other other JJ cord-262892-n38r8n70 216 34 therapeutic therapeutic JJ cord-262892-n38r8n70 216 35 agents agent NNS cord-262892-n38r8n70 216 36 ( ( -LRB- cord-262892-n38r8n70 216 37 including include VBG cord-262892-n38r8n70 216 38 growth growth NN cord-262892-n38r8n70 216 39 hormone hormone NN cord-262892-n38r8n70 216 40 and and CC cord-262892-n38r8n70 216 41 the the DT cord-262892-n38r8n70 216 42 anabolic anabolic JJ cord-262892-n38r8n70 216 43 steroid steroid NN cord-262892-n38r8n70 216 44 oxandrolone oxandrolone NN cord-262892-n38r8n70 216 45 ) ) -RRB- cord-262892-n38r8n70 216 46 are be VBP cord-262892-n38r8n70 216 47 prescribed prescribe VBN cord-262892-n38r8n70 216 48 very very RB cord-262892-n38r8n70 216 49 rarely rarely RB cord-262892-n38r8n70 216 50 , , , cord-262892-n38r8n70 216 51 if if IN cord-262892-n38r8n70 216 52 at at RB cord-262892-n38r8n70 216 53 all all RB cord-262892-n38r8n70 216 54 , , , cord-262892-n38r8n70 216 55 to to IN cord-262892-n38r8n70 216 56 subjects subject NNS cord-262892-n38r8n70 216 57 with with IN cord-262892-n38r8n70 216 58 HIV HIV NNP cord-262892-n38r8n70 216 59 . . . cord-262892-n38r8n70 217 1 In in IN cord-262892-n38r8n70 217 2 the the DT cord-262892-n38r8n70 217 3 1980s 1980 NNS cord-262892-n38r8n70 217 4 and and CC cord-262892-n38r8n70 217 5 early early JJ cord-262892-n38r8n70 217 6 1990s 1990 NNS cord-262892-n38r8n70 217 7 , , , cord-262892-n38r8n70 217 8 the the DT cord-262892-n38r8n70 217 9 devastating devastating JJ cord-262892-n38r8n70 217 10 effects effect NNS cord-262892-n38r8n70 217 11 of of IN cord-262892-n38r8n70 217 12 HIV HIV NNP cord-262892-n38r8n70 217 13 infection infection NN cord-262892-n38r8n70 217 14 on on IN cord-262892-n38r8n70 217 15 the the DT cord-262892-n38r8n70 217 16 health health NN cord-262892-n38r8n70 217 17 of of IN cord-262892-n38r8n70 217 18 infants infant NNS cord-262892-n38r8n70 217 19 , , , cord-262892-n38r8n70 217 20 children child NNS cord-262892-n38r8n70 217 21 , , , cord-262892-n38r8n70 217 22 and and CC cord-262892-n38r8n70 217 23 adolescents adolescent NNS cord-262892-n38r8n70 217 24 became become VBD cord-262892-n38r8n70 217 25 apparent apparent JJ cord-262892-n38r8n70 217 26 and and CC cord-262892-n38r8n70 217 27 required require VBD cord-262892-n38r8n70 217 28 a a DT cord-262892-n38r8n70 217 29 rapid rapid JJ cord-262892-n38r8n70 217 30 and and CC cord-262892-n38r8n70 217 31 effective effective JJ cord-262892-n38r8n70 217 32 response response NN cord-262892-n38r8n70 217 33 globally globally RB cord-262892-n38r8n70 217 34 . . . cord-262892-n38r8n70 218 1 Over over IN cord-262892-n38r8n70 218 2 time time NN cord-262892-n38r8n70 218 3 , , , cord-262892-n38r8n70 218 4 in in IN cord-262892-n38r8n70 218 5 the the DT cord-262892-n38r8n70 218 6 United United NNP cord-262892-n38r8n70 218 7 States States NNP cord-262892-n38r8n70 218 8 , , , cord-262892-n38r8n70 218 9 with with IN cord-262892-n38r8n70 218 10 the the DT cord-262892-n38r8n70 218 11 introduction introduction NN cord-262892-n38r8n70 218 12 of of IN cord-262892-n38r8n70 218 13 ARVs arv NNS cord-262892-n38r8n70 218 14 , , , cord-262892-n38r8n70 218 15 the the DT cord-262892-n38r8n70 218 16 clinical clinical JJ cord-262892-n38r8n70 218 17 manifestations manifestation NNS cord-262892-n38r8n70 218 18 associated associate VBN cord-262892-n38r8n70 218 19 with with IN cord-262892-n38r8n70 218 20 HIV HIV NNP cord-262892-n38r8n70 218 21 infection infection NN cord-262892-n38r8n70 218 22 as as RB cord-262892-n38r8n70 218 23 well well RB cord-262892-n38r8n70 218 24 as as IN cord-262892-n38r8n70 218 25 its -PRON- PRP$ cord-262892-n38r8n70 218 26 treatment treatment NN cord-262892-n38r8n70 218 27 were be VBD cord-262892-n38r8n70 218 28 seen see VBN cord-262892-n38r8n70 218 29 to to TO cord-262892-n38r8n70 218 30 increase increase VB cord-262892-n38r8n70 218 31 , , , cord-262892-n38r8n70 218 32 driven drive VBN cord-262892-n38r8n70 218 33 by by IN cord-262892-n38r8n70 218 34 the the DT cord-262892-n38r8n70 218 35 short short JJ cord-262892-n38r8n70 218 36 - - HYPH cord-262892-n38r8n70 218 37 and and CC cord-262892-n38r8n70 218 38 long long JJ cord-262892-n38r8n70 218 39 - - HYPH cord-262892-n38r8n70 218 40 term term NN cord-262892-n38r8n70 218 41 toxicities toxicity NNS cord-262892-n38r8n70 218 42 of of IN cord-262892-n38r8n70 218 43 these these DT cord-262892-n38r8n70 218 44 new new JJ cord-262892-n38r8n70 218 45 formulations formulation NNS cord-262892-n38r8n70 218 46 in in IN cord-262892-n38r8n70 218 47 combination combination NN cord-262892-n38r8n70 218 48 . . . cord-262892-n38r8n70 219 1 In in IN cord-262892-n38r8n70 219 2 children child NNS cord-262892-n38r8n70 219 3 with with IN cord-262892-n38r8n70 219 4 HIV HIV NNP cord-262892-n38r8n70 219 5 , , , cord-262892-n38r8n70 219 6 these these DT cord-262892-n38r8n70 219 7 manifestations manifestation NNS cord-262892-n38r8n70 219 8 reflected reflect VBD cord-262892-n38r8n70 219 9 metabolic metabolic JJ cord-262892-n38r8n70 219 10 changes change NNS cord-262892-n38r8n70 219 11 ; ; , cord-262892-n38r8n70 219 12 wasting waste VBG cord-262892-n38r8n70 219 13 and and CC cord-262892-n38r8n70 219 14 stunting stunt VBG cord-262892-n38r8n70 219 15 from from IN cord-262892-n38r8n70 219 16 gastrointestinal gastrointestinal JJ cord-262892-n38r8n70 219 17 dysfunction dysfunction NN cord-262892-n38r8n70 219 18 were be VBD cord-262892-n38r8n70 219 19 most most RBS cord-262892-n38r8n70 219 20 often often RB cord-262892-n38r8n70 219 21 described describe VBN cord-262892-n38r8n70 219 22 in in IN cord-262892-n38r8n70 219 23 the the DT cord-262892-n38r8n70 219 24 1980s 1980 NNS cord-262892-n38r8n70 219 25 , , , cord-262892-n38r8n70 219 26 but but CC cord-262892-n38r8n70 219 27 new new JJ cord-262892-n38r8n70 219 28 clinical clinical JJ cord-262892-n38r8n70 219 29 concerns concern NNS cord-262892-n38r8n70 219 30 in in IN cord-262892-n38r8n70 219 31 the the DT cord-262892-n38r8n70 219 32 early early JJ cord-262892-n38r8n70 219 33 2000s 2000 NNS cord-262892-n38r8n70 219 34 were be VBD cord-262892-n38r8n70 219 35 related relate VBN cord-262892-n38r8n70 219 36 to to IN cord-262892-n38r8n70 219 37 altered alter VBN cord-262892-n38r8n70 219 38 body body NN cord-262892-n38r8n70 219 39 composition composition NN cord-262892-n38r8n70 219 40 , , , cord-262892-n38r8n70 219 41 lipid lipid NN cord-262892-n38r8n70 219 42 abnormalities abnormality NNS cord-262892-n38r8n70 219 43 , , , cord-262892-n38r8n70 219 44 and and CC cord-262892-n38r8n70 219 45 abnormal abnormal JJ cord-262892-n38r8n70 219 46 regulation regulation NN cord-262892-n38r8n70 219 47 of of IN cord-262892-n38r8n70 219 48 glucose glucose NN cord-262892-n38r8n70 219 49 metabolism metabolism NN cord-262892-n38r8n70 219 50 . . . cord-262892-n38r8n70 220 1 These these DT cord-262892-n38r8n70 220 2 complications complication NNS cord-262892-n38r8n70 220 3 were be VBD cord-262892-n38r8n70 220 4 often often RB cord-262892-n38r8n70 220 5 attributed attribute VBN cord-262892-n38r8n70 220 6 to to IN cord-262892-n38r8n70 220 7 the the DT cord-262892-n38r8n70 220 8 first first JJ cord-262892-n38r8n70 220 9 - - HYPH cord-262892-n38r8n70 220 10 generation generation NN cord-262892-n38r8n70 220 11 NRTIs nrti NNS cord-262892-n38r8n70 220 12 and and CC cord-262892-n38r8n70 220 13 PIs pi NNS cord-262892-n38r8n70 220 14 . . . cord-262892-n38r8n70 221 1 The the DT cord-262892-n38r8n70 221 2 longterm longterm JJ cord-262892-n38r8n70 221 3 cardiovascular cardiovascular JJ cord-262892-n38r8n70 221 4 risks risk NNS cord-262892-n38r8n70 221 5 of of IN cord-262892-n38r8n70 221 6 these these DT cord-262892-n38r8n70 221 7 ARVs arv NNS cord-262892-n38r8n70 221 8 on on IN cord-262892-n38r8n70 221 9 subjects subject NNS cord-262892-n38r8n70 221 10 with with IN cord-262892-n38r8n70 221 11 HIV HIV NNP cord-262892-n38r8n70 221 12 are be VBP cord-262892-n38r8n70 221 13 still still RB cord-262892-n38r8n70 221 14 unknown unknown JJ cord-262892-n38r8n70 221 15 . . . cord-262892-n38r8n70 222 1 After after IN cord-262892-n38r8n70 222 2 2007 2007 CD cord-262892-n38r8n70 222 3 , , , cord-262892-n38r8n70 222 4 newer new JJR cord-262892-n38r8n70 222 5 PIs pi NNS cord-262892-n38r8n70 222 6 and and CC cord-262892-n38r8n70 222 7 integrase integrase NN cord-262892-n38r8n70 222 8 inhibitors inhibitor NNS cord-262892-n38r8n70 222 9 became become VBD cord-262892-n38r8n70 222 10 more more RBR cord-262892-n38r8n70 222 11 widely widely RB cord-262892-n38r8n70 222 12 available available JJ cord-262892-n38r8n70 222 13 and and CC cord-262892-n38r8n70 222 14 appear appear VBP cord-262892-n38r8n70 222 15 to to TO cord-262892-n38r8n70 222 16 have have VB cord-262892-n38r8n70 222 17 fewer few JJR cord-262892-n38r8n70 222 18 metabolic metabolic JJ cord-262892-n38r8n70 222 19 adverse adverse JJ cord-262892-n38r8n70 222 20 effects effect NNS cord-262892-n38r8n70 222 21 , , , cord-262892-n38r8n70 222 22 although although IN cord-262892-n38r8n70 222 23 ongoing ongoing JJ cord-262892-n38r8n70 222 24 surveillance surveillance NN cord-262892-n38r8n70 222 25 of of IN cord-262892-n38r8n70 222 26 these these DT cord-262892-n38r8n70 222 27 ARVs arv NNS cord-262892-n38r8n70 222 28 and and CC cord-262892-n38r8n70 222 29 tenofovir tenofovir NNP cord-262892-n38r8n70 222 30 will will MD cord-262892-n38r8n70 222 31 be be VB cord-262892-n38r8n70 222 32 important important JJ cord-262892-n38r8n70 222 33 to to TO cord-262892-n38r8n70 222 34 evaluate evaluate VB cord-262892-n38r8n70 222 35 incidences incidence NNS cord-262892-n38r8n70 222 36 of of IN cord-262892-n38r8n70 222 37 renal renal JJ cord-262892-n38r8n70 222 38 tubular tubular JJ cord-262892-n38r8n70 222 39 dysfunction dysfunction NN cord-262892-n38r8n70 222 40 and and CC cord-262892-n38r8n70 222 41 BMD bmd NN cord-262892-n38r8n70 222 42 . . . cord-262892-n38r8n70 223 1 In in IN cord-262892-n38r8n70 223 2 the the DT cord-262892-n38r8n70 223 3 course course NN cord-262892-n38r8n70 223 4 of of IN cord-262892-n38r8n70 223 5 the the DT cord-262892-n38r8n70 223 6 changes change NNS cord-262892-n38r8n70 223 7 in in IN cord-262892-n38r8n70 223 8 ART art NN cord-262892-n38r8n70 223 9 over over IN cord-262892-n38r8n70 223 10 the the DT cord-262892-n38r8n70 223 11 previous previous JJ cord-262892-n38r8n70 223 12 two two CD cord-262892-n38r8n70 223 13 decades decade NNS cord-262892-n38r8n70 223 14 , , , cord-262892-n38r8n70 223 15 optimal optimal JJ cord-262892-n38r8n70 223 16 nutritional nutritional JJ cord-262892-n38r8n70 223 17 support support NN cord-262892-n38r8n70 223 18 has have VBZ cord-262892-n38r8n70 223 19 continued continue VBN cord-262892-n38r8n70 223 20 to to TO cord-262892-n38r8n70 223 21 be be VB cord-262892-n38r8n70 223 22 a a DT cord-262892-n38r8n70 223 23 cornerstone cornerstone NN cord-262892-n38r8n70 223 24 of of IN cord-262892-n38r8n70 223 25 pediatric pediatric JJ cord-262892-n38r8n70 223 26 and and CC cord-262892-n38r8n70 223 27 adolescent adolescent JJ cord-262892-n38r8n70 223 28 HIV HIV NNP cord-262892-n38r8n70 223 29 care care NN cord-262892-n38r8n70 223 30 , , , cord-262892-n38r8n70 223 31 applying apply VBG cord-262892-n38r8n70 223 32 the the DT cord-262892-n38r8n70 223 33 same same JJ cord-262892-n38r8n70 223 34 principles principle NNS cord-262892-n38r8n70 223 35 developed develop VBN cord-262892-n38r8n70 223 36 from from IN cord-262892-n38r8n70 223 37 the the DT cord-262892-n38r8n70 223 38 early early JJ cord-262892-n38r8n70 223 39 1990s 1990 NNS cord-262892-n38r8n70 223 40 to to TO cord-262892-n38r8n70 223 41 effectively effectively RB cord-262892-n38r8n70 223 42 support support VB cord-262892-n38r8n70 223 43 infants infant NNS cord-262892-n38r8n70 223 44 , , , cord-262892-n38r8n70 223 45 children child NNS cord-262892-n38r8n70 223 46 , , , cord-262892-n38r8n70 223 47 and and CC cord-262892-n38r8n70 223 48 adolescents adolescent NNS cord-262892-n38r8n70 223 49 with with IN cord-262892-n38r8n70 223 50 HIV HIV NNP cord-262892-n38r8n70 223 51 . . . cord-262892-n38r8n70 224 1 These these DT cord-262892-n38r8n70 224 2 principles principle NNS cord-262892-n38r8n70 224 3 include include VBP cord-262892-n38r8n70 224 4 ongoing ongoe VBG cord-262892-n38r8n70 224 5 comprehensive comprehensive JJ cord-262892-n38r8n70 224 6 nutritional nutritional JJ cord-262892-n38r8n70 224 7 assessments assessment NNS cord-262892-n38r8n70 224 8 and and CC cord-262892-n38r8n70 224 9 follow follow NN cord-262892-n38r8n70 224 10 - - HYPH cord-262892-n38r8n70 224 11 up up NN cord-262892-n38r8n70 224 12 . . . cord-262892-n38r8n70 225 1 When when WRB cord-262892-n38r8n70 225 2 cART cART NNP cord-262892-n38r8n70 225 3 providing provide VBG cord-262892-n38r8n70 225 4 effective effective JJ cord-262892-n38r8n70 225 5 viral viral JJ cord-262892-n38r8n70 225 6 suppression suppression NN cord-262892-n38r8n70 225 7 was be VBD cord-262892-n38r8n70 225 8 unavailable unavailable JJ cord-262892-n38r8n70 225 9 , , , cord-262892-n38r8n70 225 10 enteral enteral JJ cord-262892-n38r8n70 225 11 and and CC cord-262892-n38r8n70 225 12 parenteral parenteral JJ cord-262892-n38r8n70 225 13 support support NN cord-262892-n38r8n70 225 14 was be VBD cord-262892-n38r8n70 225 15 associated associate VBN cord-262892-n38r8n70 225 16 with with IN cord-262892-n38r8n70 225 17 improved improved JJ cord-262892-n38r8n70 225 18 weight weight NN cord-262892-n38r8n70 225 19 and and CC cord-262892-n38r8n70 225 20 body body NN cord-262892-n38r8n70 225 21 composition composition NN cord-262892-n38r8n70 225 22 and and CC cord-262892-n38r8n70 225 23 overall overall JJ cord-262892-n38r8n70 225 24 survival survival NN cord-262892-n38r8n70 225 25 and and CC cord-262892-n38r8n70 225 26 is be VBZ cord-262892-n38r8n70 225 27 still still RB cord-262892-n38r8n70 225 28 a a DT cord-262892-n38r8n70 225 29 key key JJ cord-262892-n38r8n70 225 30 part part NN cord-262892-n38r8n70 225 31 of of IN cord-262892-n38r8n70 225 32 care care NN cord-262892-n38r8n70 225 33 for for IN cord-262892-n38r8n70 225 34 children child NNS cord-262892-n38r8n70 225 35 and and CC cord-262892-n38r8n70 225 36 adolescents adolescent NNS cord-262892-n38r8n70 225 37 who who WP cord-262892-n38r8n70 225 38 present present VBP cord-262892-n38r8n70 225 39 with with IN cord-262892-n38r8n70 225 40 advanced advanced JJ cord-262892-n38r8n70 225 41 HIV HIV NNP cord-262892-n38r8n70 225 42 disease disease NN cord-262892-n38r8n70 225 43 . . . cord-262892-n38r8n70 226 1 In in IN cord-262892-n38r8n70 226 2 addition addition NN cord-262892-n38r8n70 226 3 , , , cord-262892-n38r8n70 226 4 periodic periodic JJ cord-262892-n38r8n70 226 5 vitamin vitamin NN cord-262892-n38r8n70 226 6 A a DT cord-262892-n38r8n70 226 7 supplementation supplementation NN cord-262892-n38r8n70 226 8 in in IN cord-262892-n38r8n70 226 9 children child NNS cord-262892-n38r8n70 226 10 with with IN cord-262892-n38r8n70 226 11 HIV HIV NNP cord-262892-n38r8n70 226 12 who who WP cord-262892-n38r8n70 226 13 are be VBP cord-262892-n38r8n70 226 14 older old JJR cord-262892-n38r8n70 226 15 than than IN cord-262892-n38r8n70 226 16 6 6 CD cord-262892-n38r8n70 226 17 months month NNS cord-262892-n38r8n70 226 18 of of IN cord-262892-n38r8n70 226 19 age age NN cord-262892-n38r8n70 226 20 is be VBZ cord-262892-n38r8n70 226 21 supported support VBN cord-262892-n38r8n70 226 22 by by IN cord-262892-n38r8n70 226 23 clinical clinical JJ cord-262892-n38r8n70 226 24 trials trial NNS cord-262892-n38r8n70 226 25 in in IN cord-262892-n38r8n70 226 26 Africa Africa NNP cord-262892-n38r8n70 226 27 . . . cord-262892-n38r8n70 227 1 Children child NNS cord-262892-n38r8n70 227 2 with with IN cord-262892-n38r8n70 227 3 HIV HIV NNP cord-262892-n38r8n70 227 4 should should MD cord-262892-n38r8n70 227 5 also also RB cord-262892-n38r8n70 227 6 receive receive VB cord-262892-n38r8n70 227 7 zinc zinc NN cord-262892-n38r8n70 227 8 supplements supplement NNS cord-262892-n38r8n70 227 9 in in IN cord-262892-n38r8n70 227 10 the the DT cord-262892-n38r8n70 227 11 management management NN cord-262892-n38r8n70 227 12 of of IN cord-262892-n38r8n70 227 13 diarrhea diarrhea NN cord-262892-n38r8n70 227 14 and and CC cord-262892-n38r8n70 227 15 severe severe JJ cord-262892-n38r8n70 227 16 acute acute JJ cord-262892-n38r8n70 227 17 malnutrition malnutrition NN cord-262892-n38r8n70 227 18 in in IN cord-262892-n38r8n70 227 19 the the DT cord-262892-n38r8n70 227 20 same same JJ cord-262892-n38r8n70 227 21 way way NN cord-262892-n38r8n70 227 22 as as IN cord-262892-n38r8n70 227 23 uninfected uninfected JJ cord-262892-n38r8n70 227 24 children child NNS cord-262892-n38r8n70 227 25 with with IN cord-262892-n38r8n70 227 26 the the DT cord-262892-n38r8n70 227 27 same same JJ cord-262892-n38r8n70 227 28 conditions condition NNS cord-262892-n38r8n70 227 29 . . . cord-262892-n38r8n70 228 1 Investigators investigator NNS cord-262892-n38r8n70 228 2 should should MD cord-262892-n38r8n70 228 3 continue continue VB cord-262892-n38r8n70 228 4 to to TO cord-262892-n38r8n70 228 5 study study VB cord-262892-n38r8n70 228 6 the the DT cord-262892-n38r8n70 228 7 effects effect NNS cord-262892-n38r8n70 228 8 of of IN cord-262892-n38r8n70 228 9 oral oral JJ cord-262892-n38r8n70 228 10 hypoglycemic hypoglycemic JJ cord-262892-n38r8n70 228 11 agents agent NNS cord-262892-n38r8n70 228 12 , , , cord-262892-n38r8n70 228 13 lipidlowering lipidlowere VBG cord-262892-n38r8n70 228 14 medications medication NNS cord-262892-n38r8n70 228 15 , , , cord-262892-n38r8n70 228 16 and and CC cord-262892-n38r8n70 228 17 lifestyle lifestyle NN cord-262892-n38r8n70 228 18 changes change NNS cord-262892-n38r8n70 228 19 on on IN cord-262892-n38r8n70 228 20 cardiovascular cardiovascular JJ cord-262892-n38r8n70 228 21 risk risk NN cord-262892-n38r8n70 228 22 factors factor NNS cord-262892-n38r8n70 228 23 in in IN cord-262892-n38r8n70 228 24 patients patient NNS cord-262892-n38r8n70 228 25 with with IN cord-262892-n38r8n70 228 26 lipodystrophy lipodystrophy NN cord-262892-n38r8n70 228 27 and and CC cord-262892-n38r8n70 228 28 hyperlipidemia hyperlipidemia NN cord-262892-n38r8n70 228 29 at at IN cord-262892-n38r8n70 228 30 this this DT cord-262892-n38r8n70 228 31 time time NN cord-262892-n38r8n70 228 32 when when WRB cord-262892-n38r8n70 228 33 obesity obesity NN cord-262892-n38r8n70 228 34 has have VBZ cord-262892-n38r8n70 228 35 become become VBN cord-262892-n38r8n70 228 36 endemic endemic JJ cord-262892-n38r8n70 228 37 in in IN cord-262892-n38r8n70 228 38 many many JJ cord-262892-n38r8n70 228 39 communities community NNS cord-262892-n38r8n70 228 40 in in IN cord-262892-n38r8n70 228 41 the the DT cord-262892-n38r8n70 228 42 United United NNP cord-262892-n38r8n70 228 43 States States NNP cord-262892-n38r8n70 228 44 . . . cord-262892-n38r8n70 229 1 This this DT cord-262892-n38r8n70 229 2 unfortunate unfortunate JJ cord-262892-n38r8n70 229 3 development development NN cord-262892-n38r8n70 229 4 on on IN cord-262892-n38r8n70 229 5 long long JJ cord-262892-n38r8n70 229 6 - - HYPH cord-262892-n38r8n70 229 7 term term NN cord-262892-n38r8n70 229 8 health health NN cord-262892-n38r8n70 229 9 also also RB cord-262892-n38r8n70 229 10 has have VBZ cord-262892-n38r8n70 229 11 implications implication NNS cord-262892-n38r8n70 229 12 for for IN cord-262892-n38r8n70 229 13 children child NNS cord-262892-n38r8n70 229 14 and and CC cord-262892-n38r8n70 229 15 adolescents adolescent NNS cord-262892-n38r8n70 229 16 with with IN cord-262892-n38r8n70 229 17 HIV HIV NNP cord-262892-n38r8n70 229 18 across across IN cord-262892-n38r8n70 229 19 the the DT cord-262892-n38r8n70 229 20 United United NNP cord-262892-n38r8n70 229 21 States States NNP cord-262892-n38r8n70 229 22 . . . cord-262892-n38r8n70 230 1 Nevertheless nevertheless RB cord-262892-n38r8n70 230 2 , , , cord-262892-n38r8n70 230 3 the the DT cord-262892-n38r8n70 230 4 overall overall JJ cord-262892-n38r8n70 230 5 outlook outlook NN cord-262892-n38r8n70 230 6 for for IN cord-262892-n38r8n70 230 7 children child NNS cord-262892-n38r8n70 230 8 with with IN cord-262892-n38r8n70 230 9 HIV HIV NNP cord-262892-n38r8n70 230 10 has have VBZ cord-262892-n38r8n70 230 11 improved improve VBN cord-262892-n38r8n70 230 12 significantly significantly RB cord-262892-n38r8n70 230 13 since since IN cord-262892-n38r8n70 230 14 the the DT cord-262892-n38r8n70 230 15 1990s 1990 NNS cord-262892-n38r8n70 230 16 , , , cord-262892-n38r8n70 230 17 as as IN cord-262892-n38r8n70 230 18 reflected reflect VBN cord-262892-n38r8n70 230 19 in in IN cord-262892-n38r8n70 230 20 the the DT cord-262892-n38r8n70 230 21 reduced reduce VBN cord-262892-n38r8n70 230 22 rates rate NNS cord-262892-n38r8n70 230 23 of of IN cord-262892-n38r8n70 230 24 morbidity morbidity NN cord-262892-n38r8n70 230 25 and and CC cord-262892-n38r8n70 230 26 mortality mortality NN cord-262892-n38r8n70 230 27 and and CC cord-262892-n38r8n70 230 28 improved improved JJ cord-262892-n38r8n70 230 29 quality quality NN cord-262892-n38r8n70 230 30 of of IN cord-262892-n38r8n70 230 31 life life NN cord-262892-n38r8n70 230 32 . . . cord-262892-n38r8n70 231 1 Perhaps perhaps RB cord-262892-n38r8n70 231 2 a a DT cord-262892-n38r8n70 231 3 measure measure NN cord-262892-n38r8n70 231 4 of of IN cord-262892-n38r8n70 231 5 the the DT cord-262892-n38r8n70 231 6 latter latter JJ cord-262892-n38r8n70 231 7 is be VBZ cord-262892-n38r8n70 231 8 the the DT cord-262892-n38r8n70 231 9 overall overall JJ cord-262892-n38r8n70 231 10 medication medication NN cord-262892-n38r8n70 231 11 burden burden NN cord-262892-n38r8n70 231 12 . . . cord-262892-n38r8n70 232 1 Figure figure NN cord-262892-n38r8n70 232 2 9 9 CD cord-262892-n38r8n70 232 3 . . . cord-262892-n38r8n70 233 1 1 1 CD cord-262892-n38r8n70 233 2 is be VBZ cord-262892-n38r8n70 233 3 a a DT cord-262892-n38r8n70 233 4 child child NN cord-262892-n38r8n70 233 5 's 's POS cord-262892-n38r8n70 233 6 medications medication NNS cord-262892-n38r8n70 233 7 , , , cord-262892-n38r8n70 233 8 as as IN cord-262892-n38r8n70 233 9 shown show VBN cord-262892-n38r8n70 233 10 by by IN cord-262892-n38r8n70 233 11 Oleske Oleske NNP cord-262892-n38r8n70 233 12 et et NNP cord-262892-n38r8n70 233 13 al al NNP cord-262892-n38r8n70 233 14 . . . cord-262892-n38r8n70 234 1 [ [ -LRB- cord-262892-n38r8n70 234 2 57 57 CD cord-262892-n38r8n70 234 3 ] ] -RRB- cord-262892-n38r8n70 234 4 . . . cord-262892-n38r8n70 235 1 Figure figure NN cord-262892-n38r8n70 235 2 9 9 CD cord-262892-n38r8n70 235 3 .2 .2 CD cord-262892-n38r8n70 235 4 shows show VBZ cord-262892-n38r8n70 235 5 the the DT cord-262892-n38r8n70 235 6 pill pill NN cord-262892-n38r8n70 235 7 burden burden NN cord-262892-n38r8n70 235 8 for for IN cord-262892-n38r8n70 235 9 a a DT cord-262892-n38r8n70 235 10 number number NN cord-262892-n38r8n70 235 11 of of IN cord-262892-n38r8n70 235 12 adolescent adolescent JJ cord-262892-n38r8n70 235 13 patients patient NNS cord-262892-n38r8n70 235 14 in in IN cord-262892-n38r8n70 235 15 the the DT cord-262892-n38r8n70 235 16 United United NNP cord-262892-n38r8n70 235 17 States States NNP cord-262892-n38r8n70 235 18 in in IN cord-262892-n38r8n70 235 19 2014 2014 CD cord-262892-n38r8n70 235 20 . . . cord-262892-n38r8n70 236 1 The the DT cord-262892-n38r8n70 236 2 last last JJ cord-262892-n38r8n70 236 3 paragraph paragraph NN cord-262892-n38r8n70 236 4 of of IN cord-262892-n38r8n70 236 5 Dr. Dr. NNP cord-262892-n38r8n70 236 6 Oleske Oleske NNP cord-262892-n38r8n70 236 7 's 's POS cord-262892-n38r8n70 236 8 article article NN cord-262892-n38r8n70 236 9 still still RB cord-262892-n38r8n70 236 10 relevant relevant JJ cord-262892-n38r8n70 236 11 for for IN cord-262892-n38r8n70 236 12 2014 2014 CD cord-262892-n38r8n70 236 13 . . . cord-262892-n38r8n70 237 1 To to TO cord-262892-n38r8n70 237 2 quote quote VB cord-262892-n38r8n70 237 3 directly directly RB cord-262892-n38r8n70 237 4 , , , cord-262892-n38r8n70 237 5 " " `` cord-262892-n38r8n70 237 6 Compassionate compassionate JJ cord-262892-n38r8n70 237 7 , , , cord-262892-n38r8n70 237 8 comprehensive comprehensive JJ cord-262892-n38r8n70 237 9 , , , cord-262892-n38r8n70 237 10 and and CC cord-262892-n38r8n70 237 11 coordinated coordinate VBN cord-262892-n38r8n70 237 12 clinical clinical JJ cord-262892-n38r8n70 237 13 care care NN cord-262892-n38r8n70 237 14 services service NNS cord-262892-n38r8n70 237 15 are be VBP cord-262892-n38r8n70 237 16 required require VBN cord-262892-n38r8n70 237 17 for for IN cord-262892-n38r8n70 237 18 all all DT cord-262892-n38r8n70 237 19 HIV HIV NNP cord-262892-n38r8n70 237 20 - - HYPH cord-262892-n38r8n70 237 21 infected infect VBN cord-262892-n38r8n70 237 22 infants infant NNS cord-262892-n38r8n70 237 23 and and CC cord-262892-n38r8n70 237 24 children child NNS cord-262892-n38r8n70 237 25 through through IN cord-262892-n38r8n70 237 26 adolescence adolescence NN cord-262892-n38r8n70 237 27 . . . cord-262892-n38r8n70 238 1 We -PRON- PRP cord-262892-n38r8n70 238 2 must must MD cord-262892-n38r8n70 238 3 not not RB cord-262892-n38r8n70 238 4 underestimate underestimate VB cord-262892-n38r8n70 238 5 their -PRON- PRP$ cord-262892-n38r8n70 238 6 needs need NNS cord-262892-n38r8n70 238 7 . . . cord-262892-n38r8n70 239 1 As as IN cord-262892-n38r8n70 239 2 we -PRON- PRP cord-262892-n38r8n70 239 3 improve improve VBP cord-262892-n38r8n70 239 4 their -PRON- PRP$ cord-262892-n38r8n70 239 5 longevity longevity NN cord-262892-n38r8n70 239 6 with with IN cord-262892-n38r8n70 239 7 advances advance NNS cord-262892-n38r8n70 239 8 in in IN cord-262892-n38r8n70 239 9 primary primary JJ cord-262892-n38r8n70 239 10 HIV HIV NNP cord-262892-n38r8n70 239 11 therapies therapy NNS cord-262892-n38r8n70 239 12 , , , cord-262892-n38r8n70 239 13 we -PRON- PRP cord-262892-n38r8n70 239 14 must must MD cord-262892-n38r8n70 239 15 not not RB cord-262892-n38r8n70 239 16 let let VB cord-262892-n38r8n70 239 17 quality quality NN cord-262892-n38r8n70 239 18 of of IN cord-262892-n38r8n70 239 19 life life NN cord-262892-n38r8n70 239 20 suffer suffer VBP cord-262892-n38r8n70 239 21 due due IN cord-262892-n38r8n70 239 22 to to IN cord-262892-n38r8n70 239 23 a a DT cord-262892-n38r8n70 239 24 lack lack NN cord-262892-n38r8n70 239 25 of of IN cord-262892-n38r8n70 239 26 nutritional nutritional JJ cord-262892-n38r8n70 239 27 intervention intervention NN cord-262892-n38r8n70 239 28 . . . cord-262892-n38r8n70 240 1 " " `` cord-262892-n38r8n70 240 2 Global global JJ cord-262892-n38r8n70 240 3 , , , cord-262892-n38r8n70 240 4 regional regional JJ cord-262892-n38r8n70 240 5 , , , cord-262892-n38r8n70 240 6 and and CC cord-262892-n38r8n70 240 7 national national JJ cord-262892-n38r8n70 240 8 causes cause NNS cord-262892-n38r8n70 240 9 of of IN cord-262892-n38r8n70 240 10 child child NN cord-262892-n38r8n70 240 11 mortality mortality NN cord-262892-n38r8n70 240 12 in in IN cord-262892-n38r8n70 240 13 2008 2008 CD cord-262892-n38r8n70 240 14 : : : cord-262892-n38r8n70 240 15 a a DT cord-262892-n38r8n70 240 16 systematic systematic JJ cord-262892-n38r8n70 240 17 analysis analysis NN cord-262892-n38r8n70 240 18 Achievements achievement NNS cord-262892-n38r8n70 240 19 in in IN cord-262892-n38r8n70 240 20 Public Public NNP cord-262892-n38r8n70 240 21 Health Health NNP cord-262892-n38r8n70 240 22 Reduction Reduction NNP cord-262892-n38r8n70 240 23 in in IN cord-262892-n38r8n70 240 24 perinatal perinatal JJ cord-262892-n38r8n70 240 25 transmission transmission NN cord-262892-n38r8n70 240 26 of of IN cord-262892-n38r8n70 240 27 HIV HIV NNP cord-262892-n38r8n70 240 28 infection infection NN cord-262892-n38r8n70 240 29 - - : cord-262892-n38r8n70 240 30 United United NNP cord-262892-n38r8n70 240 31 States States NNP cord-262892-n38r8n70 241 1 Recent recent JJ cord-262892-n38r8n70 241 2 trends trend NNS cord-262892-n38r8n70 241 3 in in IN cord-262892-n38r8n70 241 4 the the DT cord-262892-n38r8n70 241 5 incidence incidence NN cord-262892-n38r8n70 241 6 and and CC cord-262892-n38r8n70 241 7 morbidity morbidity NN cord-262892-n38r8n70 241 8 that that WDT cord-262892-n38r8n70 241 9 are be VBP cord-262892-n38r8n70 241 10 associated associate VBN cord-262892-n38r8n70 241 11 with with IN cord-262892-n38r8n70 241 12 perinatal perinatal JJ cord-262892-n38r8n70 241 13 human human JJ cord-262892-n38r8n70 241 14 immunodeficiency immunodeficiency NN cord-262892-n38r8n70 241 15 virus virus NN cord-262892-n38r8n70 241 16 infection infection NN cord-262892-n38r8n70 241 17 in in IN cord-262892-n38r8n70 241 18 the the DT cord-262892-n38r8n70 241 19 United United NNP cord-262892-n38r8n70 241 20 States States NNP cord-262892-n38r8n70 241 21 Combination Combination NNP cord-262892-n38r8n70 241 22 antiretroviral antiretroviral JJ cord-262892-n38r8n70 241 23 strategies strategy NNS cord-262892-n38r8n70 241 24 for for IN cord-262892-n38r8n70 241 25 the the DT cord-262892-n38r8n70 241 26 treatment treatment NN cord-262892-n38r8n70 241 27 of of IN cord-262892-n38r8n70 241 28 pregnant pregnant JJ cord-262892-n38r8n70 241 29 HIV-1-infected hiv-1-infecte VBN cord-262892-n38r8n70 241 30 women woman NNS cord-262892-n38r8n70 241 31 and and CC cord-262892-n38r8n70 241 32 prevention prevention NN cord-262892-n38r8n70 241 33 of of IN cord-262892-n38r8n70 241 34 perinatal perinatal JJ cord-262892-n38r8n70 241 35 HIV-1 HIV-1 NNP cord-262892-n38r8n70 241 36 transmission transmission NN cord-262892-n38r8n70 241 37 European European NNP cord-262892-n38r8n70 241 38 Collaborative Collaborative NNP cord-262892-n38r8n70 241 39 Study Study NNP cord-262892-n38r8n70 241 40 Mother Mother NNP cord-262892-n38r8n70 241 41 - - HYPH cord-262892-n38r8n70 241 42 to to IN cord-262892-n38r8n70 241 43 - - HYPH cord-262892-n38r8n70 241 44 Child child NN cord-262892-n38r8n70 241 45 transmission transmission NN cord-262892-n38r8n70 241 46 of of IN cord-262892-n38r8n70 241 47 HIV HIV NNP cord-262892-n38r8n70 241 48 infection infection NN cord-262892-n38r8n70 241 49 in in IN cord-262892-n38r8n70 241 50 the the DT cord-262892-n38r8n70 241 51 era era NN cord-262892-n38r8n70 241 52 of of IN cord-262892-n38r8n70 241 53 highly highly RB cord-262892-n38r8n70 241 54 active active JJ cord-262892-n38r8n70 241 55 antiretroviral antiretroviral JJ cord-262892-n38r8n70 241 56 therapy therapy NN cord-262892-n38r8n70 241 57 2 2 CD cord-262892-n38r8n70 242 1 The the DT cord-262892-n38r8n70 242 2 high high JJ cord-262892-n38r8n70 242 3 number number NN cord-262892-n38r8n70 242 4 of of IN cord-262892-n38r8n70 242 5 medications medication NNS cord-262892-n38r8n70 242 6 for for IN cord-262892-n38r8n70 242 7 an an DT cord-262892-n38r8n70 242 8 adolescent adolescent NN cord-262892-n38r8n70 242 9 with with IN cord-262892-n38r8n70 242 10 HIV HIV NNP cord-262892-n38r8n70 242 11 in in IN cord-262892-n38r8n70 242 12 1 1 CD cord-262892-n38r8n70 243 1 The the DT cord-262892-n38r8n70 243 2 slew slew NN cord-262892-n38r8n70 243 3 of of IN cord-262892-n38r8n70 243 4 daily daily JJ cord-262892-n38r8n70 243 5 medications medication NNS cord-262892-n38r8n70 243 6 for for IN cord-262892-n38r8n70 243 7 a a DT cord-262892-n38r8n70 243 8 13-year 13-year JJ cord-262892-n38r8n70 243 9 - - HYPH cord-262892-n38r8n70 243 10 old old JJ cord-262892-n38r8n70 243 11 long long JJ cord-262892-n38r8n70 243 12 - - HYPH cord-262892-n38r8n70 243 13 term term NN cord-262892-n38r8n70 243 14 surviving survive VBG cord-262892-n38r8n70 243 15 patient patient NN cord-262892-n38r8n70 243 16 with with IN cord-262892-n38r8n70 243 17 perinatally perinatally RB cord-262892-n38r8n70 243 18 acquired acquire VBD cord-262892-n38r8n70 243 19 HIV HIV NNP cord-262892-n38r8n70 243 20 in in IN cord-262892-n38r8n70 243 21 1996 1996 CD cord-262892-n38r8n70 243 22 included include VBD cord-262892-n38r8n70 243 23 : : : cord-262892-n38r8n70 243 24 zidovudine zidovudine JJ cord-262892-n38r8n70 243 25 ( ( -LRB- cord-262892-n38r8n70 243 26 AZT AZT NNP cord-262892-n38r8n70 243 27 ) ) -RRB- cord-262892-n38r8n70 243 28 , , , cord-262892-n38r8n70 243 29 didanosine didanosine NNP cord-262892-n38r8n70 243 30 ( ( -LRB- cord-262892-n38r8n70 243 31 ddI ddI NNP cord-262892-n38r8n70 243 32 ) ) -RRB- cord-262892-n38r8n70 243 33 , , , cord-262892-n38r8n70 243 34 trimethoprim trimethoprim NNP cord-262892-n38r8n70 243 35 / / SYM cord-262892-n38r8n70 243 36 sulfamethoxazole sulfamethoxazole NNP cord-262892-n38r8n70 243 37 ( ( -LRB- cord-262892-n38r8n70 243 38 Tmp Tmp NNP cord-262892-n38r8n70 243 39 / / SYM cord-262892-n38r8n70 243 40 Smx Smx NNP cord-262892-n38r8n70 243 41 ) ) -RRB- cord-262892-n38r8n70 243 42 , , , cord-262892-n38r8n70 243 43 fluconzol fluconzol NNP cord-262892-n38r8n70 243 44 , , , cord-262892-n38r8n70 243 45 megase megase NNP cord-262892-n38r8n70 243 46 , , , cord-262892-n38r8n70 243 47 prednisone prednisone NNP cord-262892-n38r8n70 243 48 , , , cord-262892-n38r8n70 243 49 acyclovir acyclovir NNP cord-262892-n38r8n70 243 50 , , , cord-262892-n38r8n70 243 51 dapsone dapsone NN cord-262892-n38r8n70 243 52 , , , cord-262892-n38r8n70 243 53 biaxin biaxin NNP cord-262892-n38r8n70 243 54 , , , cord-262892-n38r8n70 243 55 zalcitabine zalcitabine NNP cord-262892-n38r8n70 243 56 ( ( -LRB- cord-262892-n38r8n70 243 57 ddC ddC NNP cord-262892-n38r8n70 243 58 ) ) -RRB- cord-262892-n38r8n70 243 59 , , , cord-262892-n38r8n70 243 60 albuterol albuterol NNP cord-262892-n38r8n70 243 61 , , , cord-262892-n38r8n70 243 62 isonicotinylhydrazine isonicotinylhydrazine NNP cord-262892-n38r8n70 243 63 ( ( -LRB- cord-262892-n38r8n70 243 64 INH INH NNP cord-262892-n38r8n70 243 65 ) ) -RRB- cord-262892-n38r8n70 243 66 , , , cord-262892-n38r8n70 243 67 rifampin rifampin NN cord-262892-n38r8n70 243 68 , , , cord-262892-n38r8n70 243 69 ranitidine ranitidine NN cord-262892-n38r8n70 243 70 ( ( -LRB- cord-262892-n38r8n70 243 71 Zantac Zantac NNP cord-262892-n38r8n70 243 72 ) ) -RRB- cord-262892-n38r8n70 243 73 Two two CD cord-262892-n38r8n70 243 74 - - HYPH cord-262892-n38r8n70 243 75 dose dose NN cord-262892-n38r8n70 243 76 intrapartum intrapartum NNP cord-262892-n38r8n70 243 77 / / SYM cord-262892-n38r8n70 243 78 newborn newborn JJ cord-262892-n38r8n70 243 79 nevirapine nevirapine NNP cord-262892-n38r8n70 243 80 and and CC cord-262892-n38r8n70 243 81 standard standard JJ cord-262892-n38r8n70 243 82 antiretroviral antiretroviral JJ cord-262892-n38r8n70 243 83 therapy therapy NN cord-262892-n38r8n70 243 84 to to TO cord-262892-n38r8n70 243 85 reduce reduce VB cord-262892-n38r8n70 243 86 perinatal perinatal JJ cord-262892-n38r8n70 243 87 HIV HIV NNP cord-262892-n38r8n70 243 88 transmission transmission NN cord-262892-n38r8n70 243 89 : : : cord-262892-n38r8n70 243 90 a a DT cord-262892-n38r8n70 243 91 randomized randomized JJ cord-262892-n38r8n70 243 92 trial trial NN cord-262892-n38r8n70 243 93 Low low JJ cord-262892-n38r8n70 243 94 rates rate NNS cord-262892-n38r8n70 243 95 of of IN cord-262892-n38r8n70 243 96 mother mother NN cord-262892-n38r8n70 243 97 - - HYPH cord-262892-n38r8n70 243 98 to to IN cord-262892-n38r8n70 243 99 - - HYPH cord-262892-n38r8n70 243 100 child child NN cord-262892-n38r8n70 243 101 transmission transmission NN cord-262892-n38r8n70 243 102 of of IN cord-262892-n38r8n70 243 103 HIV HIV NNP cord-262892-n38r8n70 243 104 following follow VBG cord-262892-n38r8n70 243 105 effective effective JJ cord-262892-n38r8n70 243 106 pregnancy pregnancy NN cord-262892-n38r8n70 243 107 interventions intervention NNS cord-262892-n38r8n70 243 108 in in IN cord-262892-n38r8n70 243 109 the the DT cord-262892-n38r8n70 243 110 United United NNP cord-262892-n38r8n70 243 111 Kingdom Kingdom NNP cord-262892-n38r8n70 243 112 and and CC cord-262892-n38r8n70 243 113 Ireland Ireland NNP cord-262892-n38r8n70 244 1 Earlier early JJR cord-262892-n38r8n70 244 2 initiation initiation NN cord-262892-n38r8n70 244 3 of of IN cord-262892-n38r8n70 244 4 ART art NN cord-262892-n38r8n70 244 5 and and CC cord-262892-n38r8n70 244 6 further further JJ cord-262892-n38r8n70 244 7 decline decline NN cord-262892-n38r8n70 244 8 in in IN cord-262892-n38r8n70 244 9 mother mother NN cord-262892-n38r8n70 244 10 - - HYPH cord-262892-n38r8n70 244 11 to to IN cord-262892-n38r8n70 244 12 - - HYPH cord-262892-n38r8n70 244 13 child child NN cord-262892-n38r8n70 244 14 HIV HIV NNP cord-262892-n38r8n70 244 15 transmission transmission NN cord-262892-n38r8n70 244 16 rates rate NNS cord-262892-n38r8n70 244 17 Racial racial JJ cord-262892-n38r8n70 244 18 / / SYM cord-262892-n38r8n70 244 19 ethnic ethnic JJ cord-262892-n38r8n70 244 20 disparities disparity NNS cord-262892-n38r8n70 244 21 among among IN cord-262892-n38r8n70 244 22 children child NNS cord-262892-n38r8n70 244 23 with with IN cord-262892-n38r8n70 244 24 diagnoses diagnosis NNS cord-262892-n38r8n70 244 25 of of IN cord-262892-n38r8n70 244 26 perinatal perinatal JJ cord-262892-n38r8n70 244 27 HIV HIV NNP cord-262892-n38r8n70 244 28 infection infection NN cord-262892-n38r8n70 244 29 -34 -34 CD cord-262892-n38r8n70 244 30 states state NNS cord-262892-n38r8n70 244 31 Towards towards IN cord-262892-n38r8n70 244 32 universal universal JJ cord-262892-n38r8n70 244 33 access access NN cord-262892-n38r8n70 244 34 : : : cord-262892-n38r8n70 244 35 scaling scale VBG cord-262892-n38r8n70 244 36 - - HYPH cord-262892-n38r8n70 244 37 up up RP cord-262892-n38r8n70 244 38 priority priority NN cord-262892-n38r8n70 244 39 HIV/ HIV/ NNP cord-262892-n38r8n70 244 40 AIDS AIDS NNP cord-262892-n38r8n70 244 41 interventions intervention NNS cord-262892-n38r8n70 244 42 in in IN cord-262892-n38r8n70 244 43 the the DT cord-262892-n38r8n70 244 44 health health NN cord-262892-n38r8n70 244 45 sector sector NN cord-262892-n38r8n70 244 46 HIV-1 HIV-1 NNP cord-262892-n38r8n70 244 47 infection infection NN cord-262892-n38r8n70 244 48 in in IN cord-262892-n38r8n70 244 49 children child NNS cord-262892-n38r8n70 244 50 : : : cord-262892-n38r8n70 244 51 a a DT cord-262892-n38r8n70 244 52 clinical clinical JJ cord-262892-n38r8n70 244 53 and and CC cord-262892-n38r8n70 244 54 immunologic immunologic JJ cord-262892-n38r8n70 244 55 overview overview NN cord-262892-n38r8n70 244 56 Evolution evolution NN cord-262892-n38r8n70 244 57 and and CC cord-262892-n38r8n70 244 58 transmission transmission NN cord-262892-n38r8n70 244 59 of of IN cord-262892-n38r8n70 244 60 stable stable JJ cord-262892-n38r8n70 244 61 CTL CTL NNP cord-262892-n38r8n70 244 62 escape escape NN cord-262892-n38r8n70 244 63 mutations mutation NNS cord-262892-n38r8n70 244 64 in in IN cord-262892-n38r8n70 244 65 HIV HIV NNP cord-262892-n38r8n70 244 66 infection infection NN cord-262892-n38r8n70 245 1 The the DT cord-262892-n38r8n70 245 2 European European NNP cord-262892-n38r8n70 245 3 collaborative collaborative NN cord-262892-n38r8n70 245 4 study study NN cord-262892-n38r8n70 245 5 Association Association NNP cord-262892-n38r8n70 245 6 of of IN cord-262892-n38r8n70 245 7 human human JJ cord-262892-n38r8n70 245 8 immunodeficiency immunodeficiency NN cord-262892-n38r8n70 245 9 virus virus NN cord-262892-n38r8n70 245 10 ( ( -LRB- cord-262892-n38r8n70 245 11 HIV HIV NNP cord-262892-n38r8n70 245 12 ) ) -RRB- cord-262892-n38r8n70 245 13 load load VBP cord-262892-n38r8n70 245 14 early early RB cord-262892-n38r8n70 245 15 in in IN cord-262892-n38r8n70 245 16 life life NN cord-262892-n38r8n70 245 17 with with IN cord-262892-n38r8n70 245 18 disease disease NN cord-262892-n38r8n70 245 19 progression progression NN cord-262892-n38r8n70 245 20 among among IN cord-262892-n38r8n70 245 21 HIV HIV NNP cord-262892-n38r8n70 245 22 - - HYPH cord-262892-n38r8n70 245 23 infected infect VBN cord-262892-n38r8n70 245 24 infants infant NNS cord-262892-n38r8n70 246 1 The the DT cord-262892-n38r8n70 246 2 relationship relationship NN cord-262892-n38r8n70 246 3 between between IN cord-262892-n38r8n70 246 4 serum serum NN cord-262892-n38r8n70 246 5 human human JJ cord-262892-n38r8n70 246 6 immunodeficiency immunodeficiency NN cord-262892-n38r8n70 246 7 virus virus NN cord-262892-n38r8n70 246 8 type type NN cord-262892-n38r8n70 246 9 1 1 CD cord-262892-n38r8n70 246 10 ( ( -LRB- cord-262892-n38r8n70 246 11 HIV-1 HIV-1 NNP cord-262892-n38r8n70 246 12 ) ) -RRB- cord-262892-n38r8n70 246 13 RNA RNA NNP cord-262892-n38r8n70 246 14 level level NN cord-262892-n38r8n70 246 15 , , , cord-262892-n38r8n70 246 16 CD4 CD4 NNP cord-262892-n38r8n70 246 17 lymphocyte lymphocyte NN cord-262892-n38r8n70 246 18 percent percent NN cord-262892-n38r8n70 246 19 , , , cord-262892-n38r8n70 246 20 and and CC cord-262892-n38r8n70 246 21 long long JJ cord-262892-n38r8n70 246 22 - - HYPH cord-262892-n38r8n70 246 23 term term NN cord-262892-n38r8n70 246 24 mortality mortality NN cord-262892-n38r8n70 246 25 risk risk NN cord-262892-n38r8n70 246 26 in in IN cord-262892-n38r8n70 246 27 HIV-1-infected hiv-1-infecte VBN cord-262892-n38r8n70 246 28 children child NNS cord-262892-n38r8n70 246 29 Management Management NNP cord-262892-n38r8n70 246 30 of of IN cord-262892-n38r8n70 246 31 gastrointestinal gastrointestinal JJ cord-262892-n38r8n70 246 32 disorders disorder NNS cord-262892-n38r8n70 246 33 in in IN cord-262892-n38r8n70 246 34 children child NNS cord-262892-n38r8n70 246 35 with with IN cord-262892-n38r8n70 246 36 HIV HIV NNP cord-262892-n38r8n70 246 37 infection infection NN cord-262892-n38r8n70 247 1 HIV HIV NNP cord-262892-n38r8n70 247 2 enteropathy enteropathy NNP cord-262892-n38r8n70 247 3 : : : cord-262892-n38r8n70 248 1 crypt crypt JJ cord-262892-n38r8n70 248 2 stem stem NN cord-262892-n38r8n70 248 3 and and CC cord-262892-n38r8n70 248 4 transit transit NN cord-262892-n38r8n70 248 5 cell cell NN cord-262892-n38r8n70 248 6 hyperproliferation hyperproliferation NNP cord-262892-n38r8n70 248 7 induces induce VBZ cord-262892-n38r8n70 248 8 villous villous NNP cord-262892-n38r8n70 248 9 atrophy atrophy NN cord-262892-n38r8n70 248 10 in in IN cord-262892-n38r8n70 248 11 HIV HIV NNP cord-262892-n38r8n70 248 12 / / SYM cord-262892-n38r8n70 248 13 microsporidia microsporidia NNP cord-262892-n38r8n70 248 14 - - HYPH cord-262892-n38r8n70 248 15 infected infect VBN cord-262892-n38r8n70 248 16 jejunal jejunal JJ cord-262892-n38r8n70 248 17 mucosa mucosa NN cord-262892-n38r8n70 248 18 Enteropathies Enteropathies NNPS cord-262892-n38r8n70 248 19 in in IN cord-262892-n38r8n70 248 20 the the DT cord-262892-n38r8n70 248 21 developing develop VBG cord-262892-n38r8n70 248 22 world world NN cord-262892-n38r8n70 248 23 : : : cord-262892-n38r8n70 248 24 neglected neglect VBN cord-262892-n38r8n70 248 25 effects effect NNS cord-262892-n38r8n70 248 26 on on IN cord-262892-n38r8n70 248 27 global global JJ cord-262892-n38r8n70 248 28 health health NN cord-262892-n38r8n70 248 29 Ritonavir Ritonavir NNP cord-262892-n38r8n70 248 30 combination combination NN cord-262892-n38r8n70 248 31 therapy therapy NN cord-262892-n38r8n70 248 32 restores restore VBZ cord-262892-n38r8n70 248 33 intestinal intestinal JJ cord-262892-n38r8n70 248 34 function function NN cord-262892-n38r8n70 248 35 in in IN cord-262892-n38r8n70 248 36 children child NNS cord-262892-n38r8n70 248 37 with with IN cord-262892-n38r8n70 248 38 advanced advanced JJ cord-262892-n38r8n70 248 39 HIV HIV NNP cord-262892-n38r8n70 248 40 disease disease NN cord-262892-n38r8n70 248 41 Aetiology Aetiology NNP cord-262892-n38r8n70 248 42 and and CC cord-262892-n38r8n70 248 43 management management NN cord-262892-n38r8n70 248 44 of of IN cord-262892-n38r8n70 248 45 malnutrition malnutrition NN cord-262892-n38r8n70 248 46 in in IN cord-262892-n38r8n70 248 47 HIV HIV NNP cord-262892-n38r8n70 248 48 - - HYPH cord-262892-n38r8n70 248 49 positive positive JJ cord-262892-n38r8n70 248 50 children child NNS cord-262892-n38r8n70 248 51 Nutritional nutritional JJ cord-262892-n38r8n70 248 52 aspects aspect NNS cord-262892-n38r8n70 248 53 of of IN cord-262892-n38r8n70 248 54 HIV HIV NNP cord-262892-n38r8n70 248 55 - - HYPH cord-262892-n38r8n70 248 56 infected infect VBN cord-262892-n38r8n70 248 57 children child NNS cord-262892-n38r8n70 248 58 receiving receive VBG cord-262892-n38r8n70 248 59 highly highly RB cord-262892-n38r8n70 248 60 active active JJ cord-262892-n38r8n70 248 61 antiretroviral antiretroviral JJ cord-262892-n38r8n70 248 62 therapy therapy NN cord-262892-n38r8n70 248 63 Enteric enteric JJ cord-262892-n38r8n70 248 64 infections infection NNS cord-262892-n38r8n70 248 65 and and CC cord-262892-n38r8n70 248 66 diarrhea diarrhea NN cord-262892-n38r8n70 248 67 in in IN cord-262892-n38r8n70 248 68 human human JJ cord-262892-n38r8n70 248 69 immunodeficiency immunodeficiency NN cord-262892-n38r8n70 248 70 virus virus NN cord-262892-n38r8n70 248 71 - - HYPH cord-262892-n38r8n70 248 72 infected infect VBN cord-262892-n38r8n70 248 73 persons person NNS cord-262892-n38r8n70 248 74 Microsporidia Microsporidia NNP cord-262892-n38r8n70 248 75 infection infection NN cord-262892-n38r8n70 248 76 in in IN cord-262892-n38r8n70 248 77 patients patient NNS cord-262892-n38r8n70 248 78 with with IN cord-262892-n38r8n70 248 79 human human JJ cord-262892-n38r8n70 248 80 immunodeficiency immunodeficiency NN cord-262892-n38r8n70 248 81 virus virus NN cord-262892-n38r8n70 248 82 and and CC cord-262892-n38r8n70 248 83 unexplained unexplained JJ cord-262892-n38r8n70 248 84 cholangitis cholangitis NN cord-262892-n38r8n70 248 85 Nutritional nutritional JJ cord-262892-n38r8n70 248 86 status status NN cord-262892-n38r8n70 248 87 in in IN cord-262892-n38r8n70 248 88 Malawian malawian JJ cord-262892-n38r8n70 248 89 patients patient NNS cord-262892-n38r8n70 248 90 with with IN cord-262892-n38r8n70 248 91 pulmonary pulmonary JJ cord-262892-n38r8n70 248 92 tuberculosis tuberculosis NN cord-262892-n38r8n70 248 93 and and CC cord-262892-n38r8n70 248 94 response response NN cord-262892-n38r8n70 248 95 to to IN cord-262892-n38r8n70 248 96 chemotherapy chemotherapy NN cord-262892-n38r8n70 248 97 Prospective prospective JJ cord-262892-n38r8n70 248 98 analysis analysis NN cord-262892-n38r8n70 248 99 of of IN cord-262892-n38r8n70 248 100 patterns pattern NNS cord-262892-n38r8n70 248 101 of of IN cord-262892-n38r8n70 248 102 weight weight NN cord-262892-n38r8n70 248 103 change change NN cord-262892-n38r8n70 248 104 in in IN cord-262892-n38r8n70 248 105 stage stage NN cord-262892-n38r8n70 249 1 IV IV NNP cord-262892-n38r8n70 249 2 human human JJ cord-262892-n38r8n70 249 3 immunodeficiency immunodeficiency NN cord-262892-n38r8n70 249 4 virus virus NN cord-262892-n38r8n70 249 5 infection infection NN cord-262892-n38r8n70 249 6 Nutrition Nutrition NNP cord-262892-n38r8n70 249 7 in in IN cord-262892-n38r8n70 249 8 paediatric paediatric JJ cord-262892-n38r8n70 249 9 HIV HIV NNP cord-262892-n38r8n70 249 10 infection infection NN cord-262892-n38r8n70 249 11 Magnitude magnitude NN cord-262892-n38r8n70 249 12 of of IN cord-262892-n38r8n70 249 13 body body NN cord-262892-n38r8n70 249 14 - - HYPH cord-262892-n38r8n70 249 15 cell cell NN cord-262892-n38r8n70 249 16 - - HYPH cord-262892-n38r8n70 249 17 mass mass NN cord-262892-n38r8n70 249 18 depletion depletion NN cord-262892-n38r8n70 249 19 and and CC cord-262892-n38r8n70 249 20 the the DT cord-262892-n38r8n70 249 21 timing timing NN cord-262892-n38r8n70 249 22 of of IN cord-262892-n38r8n70 249 23 death death NN cord-262892-n38r8n70 249 24 from from IN cord-262892-n38r8n70 249 25 wasting waste VBG cord-262892-n38r8n70 249 26 in in IN cord-262892-n38r8n70 249 27 AIDS AIDS NNP cord-262892-n38r8n70 249 28 Centers Centers NNPS cord-262892-n38r8n70 249 29 for for IN cord-262892-n38r8n70 249 30 Disease Disease NNP cord-262892-n38r8n70 249 31 Control Control NNP cord-262892-n38r8n70 249 32 and and CC cord-262892-n38r8n70 249 33 Prevention Prevention NNP cord-262892-n38r8n70 249 34 1994 1994 CD cord-262892-n38r8n70 249 35 revised revise VBD cord-262892-n38r8n70 249 36 classification classification NN cord-262892-n38r8n70 249 37 system system NN cord-262892-n38r8n70 249 38 for for IN cord-262892-n38r8n70 249 39 human human JJ cord-262892-n38r8n70 249 40 immunodeficiency immunodeficiency NN cord-262892-n38r8n70 249 41 virus virus NN cord-262892-n38r8n70 249 42 infection infection NN cord-262892-n38r8n70 249 43 in in IN cord-262892-n38r8n70 249 44 children child NNS cord-262892-n38r8n70 249 45 less less JJR cord-262892-n38r8n70 249 46 than than IN cord-262892-n38r8n70 249 47 13 13 CD cord-262892-n38r8n70 249 48 years year NNS cord-262892-n38r8n70 249 49 of of IN cord-262892-n38r8n70 249 50 age age NN cord-262892-n38r8n70 249 51 UNICEF UNICEF NNP cord-262892-n38r8n70 249 52 Tracking tracking NN cord-262892-n38r8n70 249 53 progress progress NN cord-262892-n38r8n70 249 54 on on IN cord-262892-n38r8n70 249 55 child child NN cord-262892-n38r8n70 249 56 and and CC cord-262892-n38r8n70 249 57 maternal maternal JJ cord-262892-n38r8n70 249 58 nutrition nutrition NN cord-262892-n38r8n70 249 59 : : : cord-262892-n38r8n70 249 60 a a DT cord-262892-n38r8n70 249 61 survival survival NN cord-262892-n38r8n70 249 62 and and CC cord-262892-n38r8n70 249 63 development development NN cord-262892-n38r8n70 249 64 priority priority NN cord-262892-n38r8n70 249 65 Micronutrient Micronutrient NNP cord-262892-n38r8n70 249 66 supplementation supplementation NN cord-262892-n38r8n70 249 67 for for IN cord-262892-n38r8n70 249 68 children child NNS cord-262892-n38r8n70 249 69 with with IN cord-262892-n38r8n70 249 70 HIV HIV NNP cord-262892-n38r8n70 249 71 infection infection NN cord-262892-n38r8n70 249 72 Incidence incidence NN cord-262892-n38r8n70 249 73 of of IN cord-262892-n38r8n70 249 74 opportunistic opportunistic JJ cord-262892-n38r8n70 249 75 and and CC cord-262892-n38r8n70 249 76 other other JJ cord-262892-n38r8n70 249 77 infections infection NNS cord-262892-n38r8n70 249 78 in in IN cord-262892-n38r8n70 249 79 HIV HIV NNP cord-262892-n38r8n70 249 80 - - HYPH cord-262892-n38r8n70 249 81 infected infect VBN cord-262892-n38r8n70 249 82 children child NNS cord-262892-n38r8n70 249 83 in in IN cord-262892-n38r8n70 249 84 the the DT cord-262892-n38r8n70 249 85 HAART HAART NNP cord-262892-n38r8n70 249 86 era era NN cord-262892-n38r8n70 249 87 Declines decline VBZ cord-262892-n38r8n70 249 88 in in IN cord-262892-n38r8n70 249 89 mortality mortality NN cord-262892-n38r8n70 249 90 rates rate NNS cord-262892-n38r8n70 249 91 and and CC cord-262892-n38r8n70 249 92 changes change NNS cord-262892-n38r8n70 249 93 in in IN cord-262892-n38r8n70 249 94 causes cause NNS cord-262892-n38r8n70 249 95 of of IN cord-262892-n38r8n70 249 96 death death NN cord-262892-n38r8n70 249 97 in in IN cord-262892-n38r8n70 249 98 HIV-1-infected hiv-1-infecte VBN cord-262892-n38r8n70 249 99 children child NNS cord-262892-n38r8n70 249 100 during during IN cord-262892-n38r8n70 249 101 the the DT cord-262892-n38r8n70 249 102 HAART HAART NNP cord-262892-n38r8n70 249 103 era era NN cord-262892-n38r8n70 249 104 HIV-1 HIV-1 NNP cord-262892-n38r8n70 249 105 drug drug NN cord-262892-n38r8n70 249 106 resistance resistance NN cord-262892-n38r8n70 249 107 in in IN cord-262892-n38r8n70 249 108 HIV-1-infected hiv-1-infecte VBN cord-262892-n38r8n70 249 109 children child NNS cord-262892-n38r8n70 249 110 in in IN cord-262892-n38r8n70 249 111 the the DT cord-262892-n38r8n70 249 112 United United NNP cord-262892-n38r8n70 249 113 Kingdom Kingdom NNP cord-262892-n38r8n70 249 114 from from IN cord-262892-n38r8n70 249 115 National National NNP cord-262892-n38r8n70 249 116 study study NN cord-262892-n38r8n70 249 117 of of IN cord-262892-n38r8n70 249 118 HIV HIV NNP cord-262892-n38r8n70 249 119 in in IN cord-262892-n38r8n70 249 120 pregnancy pregnancy NN cord-262892-n38r8n70 249 121 and and CC cord-262892-n38r8n70 249 122 childhood childhood NN cord-262892-n38r8n70 249 123 collaborative collaborative NN cord-262892-n38r8n70 249 124 HIV HIV NNP cord-262892-n38r8n70 249 125 paediatric paediatric JJ cord-262892-n38r8n70 249 126 study study NN cord-262892-n38r8n70 250 1 Increased increase VBN cord-262892-n38r8n70 250 2 lipodystrophy lipodystrophy NN cord-262892-n38r8n70 250 3 is be VBZ cord-262892-n38r8n70 250 4 associated associate VBN cord-262892-n38r8n70 250 5 with with IN cord-262892-n38r8n70 250 6 increased increase VBN cord-262892-n38r8n70 250 7 exposure exposure NN cord-262892-n38r8n70 250 8 to to IN cord-262892-n38r8n70 250 9 highly highly RB cord-262892-n38r8n70 250 10 active active JJ cord-262892-n38r8n70 250 11 antiretroviral antiretroviral JJ cord-262892-n38r8n70 250 12 therapy therapy NN cord-262892-n38r8n70 250 13 in in IN cord-262892-n38r8n70 250 14 HIV HIV NNP cord-262892-n38r8n70 250 15 - - HYPH cord-262892-n38r8n70 250 16 infected infect VBN cord-262892-n38r8n70 250 17 children child NNS cord-262892-n38r8n70 250 18 Persistent persistent JJ cord-262892-n38r8n70 250 19 non non JJ cord-262892-n38r8n70 250 20 - - JJ cord-262892-n38r8n70 250 21 gastrointestinal gastrointestinal JJ cord-262892-n38r8n70 250 22 metabolic metabolic JJ cord-262892-n38r8n70 250 23 acidosis acidosis NN cord-262892-n38r8n70 250 24 in in IN cord-262892-n38r8n70 250 25 pediatric pediatric JJ cord-262892-n38r8n70 250 26 HIV-1 HIV-1 NNP cord-262892-n38r8n70 250 27 infection infection NN cord-262892-n38r8n70 250 28 Gastrostomy Gastrostomy NNP cord-262892-n38r8n70 250 29 tube tube NN cord-262892-n38r8n70 250 30 supplementation supplementation NN cord-262892-n38r8n70 250 31 for for IN cord-262892-n38r8n70 250 32 HIV HIV NNP cord-262892-n38r8n70 250 33 - - HYPH cord-262892-n38r8n70 250 34 infected infect VBN cord-262892-n38r8n70 250 35 children child NNS cord-262892-n38r8n70 250 36 Effect effect NN cord-262892-n38r8n70 250 37 of of IN cord-262892-n38r8n70 250 38 enteral enteral NN cord-262892-n38r8n70 250 39 tube tube NN cord-262892-n38r8n70 250 40 feeding feeding NN cord-262892-n38r8n70 250 41 on on IN cord-262892-n38r8n70 250 42 growth growth NN cord-262892-n38r8n70 250 43 of of IN cord-262892-n38r8n70 250 44 children child NNS cord-262892-n38r8n70 250 45 with with IN cord-262892-n38r8n70 250 46 symptomatic symptomatic JJ cord-262892-n38r8n70 250 47 human human JJ cord-262892-n38r8n70 250 48 immunodefi- immunodefi- NN cord-262892-n38r8n70 250 49 � � NNP cord-262892-n38r8n70 250 50 ciency ciency NNP cord-262892-n38r8n70 250 51 virus virus NN cord-262892-n38r8n70 250 52 infection infection NN cord-262892-n38r8n70 251 1 Megestrol megestrol IN cord-262892-n38r8n70 251 2 acetate acetate NN cord-262892-n38r8n70 251 3 treatment treatment NN cord-262892-n38r8n70 251 4 of of IN cord-262892-n38r8n70 251 5 growth growth NN cord-262892-n38r8n70 251 6 failure failure NN cord-262892-n38r8n70 251 7 in in IN cord-262892-n38r8n70 251 8 children child NNS cord-262892-n38r8n70 251 9 infected infect VBN cord-262892-n38r8n70 251 10 with with IN cord-262892-n38r8n70 251 11 human human JJ cord-262892-n38r8n70 251 12 immunodeficiency immunodeficiency NN cord-262892-n38r8n70 251 13 virus virus NN cord-262892-n38r8n70 252 1 The the DT cord-262892-n38r8n70 252 2 effect effect NN cord-262892-n38r8n70 252 3 of of IN cord-262892-n38r8n70 252 4 protease protease NN cord-262892-n38r8n70 252 5 inhibitors inhibitor NNS cord-262892-n38r8n70 252 6 on on IN cord-262892-n38r8n70 252 7 growth growth NN cord-262892-n38r8n70 252 8 and and CC cord-262892-n38r8n70 252 9 body body NN cord-262892-n38r8n70 252 10 composition composition NN cord-262892-n38r8n70 252 11 in in IN cord-262892-n38r8n70 252 12 HIV HIV NNP cord-262892-n38r8n70 252 13 - - HYPH cord-262892-n38r8n70 252 14 infected infect VBN cord-262892-n38r8n70 252 15 children child NNS cord-262892-n38r8n70 252 16 Impact Impact NNP cord-262892-n38r8n70 252 17 of of IN cord-262892-n38r8n70 252 18 protease protease JJ cord-262892-n38r8n70 252 19 inhibitor inhibitor NN cord-262892-n38r8n70 252 20 - - HYPH cord-262892-n38r8n70 252 21 containing contain VBG cord-262892-n38r8n70 252 22 combination combination NN cord-262892-n38r8n70 252 23 antiretroviral antiretroviral JJ cord-262892-n38r8n70 252 24 therapies therapy NNS cord-262892-n38r8n70 252 25 on on IN cord-262892-n38r8n70 252 26 height height NN cord-262892-n38r8n70 252 27 and and CC cord-262892-n38r8n70 252 28 weight weight NN cord-262892-n38r8n70 252 29 growth growth NN cord-262892-n38r8n70 252 30 in in IN cord-262892-n38r8n70 252 31 HIV-1-infected hiv-1-infecte VBN cord-262892-n38r8n70 252 32 children child NNS cord-262892-n38r8n70 252 33 Prevalence prevalence NN cord-262892-n38r8n70 252 34 , , , cord-262892-n38r8n70 252 35 evolution evolution NN cord-262892-n38r8n70 252 36 and and CC cord-262892-n38r8n70 252 37 risk risk NN cord-262892-n38r8n70 252 38 factors factor NNS cord-262892-n38r8n70 252 39 for for IN cord-262892-n38r8n70 252 40 fat fat JJ cord-262892-n38r8n70 252 41 atrophy atrophy NN cord-262892-n38r8n70 252 42 and and CC cord-262892-n38r8n70 252 43 fat fat JJ cord-262892-n38r8n70 252 44 deposition deposition NN cord-262892-n38r8n70 252 45 in in IN cord-262892-n38r8n70 252 46 a a DT cord-262892-n38r8n70 252 47 cohort cohort NN cord-262892-n38r8n70 252 48 of of IN cord-262892-n38r8n70 252 49 HIV HIV NNP cord-262892-n38r8n70 252 50 - - HYPH cord-262892-n38r8n70 252 51 infected infect VBN cord-262892-n38r8n70 252 52 men man NNS cord-262892-n38r8n70 252 53 and and CC cord-262892-n38r8n70 252 54 women woman NNS cord-262892-n38r8n70 252 55 Pediatric Pediatric NNP cord-262892-n38r8n70 252 56 HIV HIV NNP cord-262892-n38r8n70 252 57 / / SYM cord-262892-n38r8n70 252 58 AIDS AIDS NNP cord-262892-n38r8n70 252 59 Cohort Cohort NNP cord-262892-n38r8n70 252 60 Study Study NNP cord-262892-n38r8n70 252 61 . . . cord-262892-n38r8n70 253 1 Body body NN cord-262892-n38r8n70 253 2 fat fat JJ cord-262892-n38r8n70 253 3 distribution distribution NN cord-262892-n38r8n70 253 4 in in IN cord-262892-n38r8n70 253 5 perinatally perinatally RB cord-262892-n38r8n70 253 6 HIV HIV NNP cord-262892-n38r8n70 253 7 infected infect VBD cord-262892-n38r8n70 253 8 and and CC cord-262892-n38r8n70 253 9 HIV HIV NNP cord-262892-n38r8n70 253 10 - - HYPH cord-262892-n38r8n70 253 11 exposed expose VBN cord-262892-n38r8n70 253 12 but but CC cord-262892-n38r8n70 253 13 uninfected uninfected JJ cord-262892-n38r8n70 253 14 children child NNS cord-262892-n38r8n70 253 15 in in IN cord-262892-n38r8n70 253 16 the the DT cord-262892-n38r8n70 253 17 era era NN cord-262892-n38r8n70 253 18 of of IN cord-262892-n38r8n70 253 19 highly highly RB cord-262892-n38r8n70 253 20 active active JJ cord-262892-n38r8n70 253 21 antiretroviral antiretroviral JJ cord-262892-n38r8n70 253 22 therapy therapy NN cord-262892-n38r8n70 253 23 : : : cord-262892-n38r8n70 253 24 outcomes outcome NNS cord-262892-n38r8n70 253 25 from from IN cord-262892-n38r8n70 253 26 the the DT cord-262892-n38r8n70 253 27 Pediatric Pediatric NNP cord-262892-n38r8n70 253 28 HIV HIV NNP cord-262892-n38r8n70 253 29 / / SYM cord-262892-n38r8n70 253 30 AIDS AIDS NNP cord-262892-n38r8n70 253 31 Cohort Cohort NNP cord-262892-n38r8n70 253 32 Study Study NNP cord-262892-n38r8n70 253 33 Regional regional JJ cord-262892-n38r8n70 253 34 body body NN cord-262892-n38r8n70 253 35 fat fat NN cord-262892-n38r8n70 253 36 distribution distribution NN cord-262892-n38r8n70 253 37 in in IN cord-262892-n38r8n70 253 38 relation relation NN cord-262892-n38r8n70 253 39 to to IN cord-262892-n38r8n70 253 40 pubertal pubertal JJ cord-262892-n38r8n70 253 41 stage stage NN cord-262892-n38r8n70 253 42 : : : cord-262892-n38r8n70 253 43 a a DT cord-262892-n38r8n70 253 44 dual dual JJ cord-262892-n38r8n70 253 45 - - HYPH cord-262892-n38r8n70 253 46 energy energy NN cord-262892-n38r8n70 253 47 X x NN cord-262892-n38r8n70 253 48 - - NN cord-262892-n38r8n70 253 49 ray ray NNP cord-262892-n38r8n70 253 50 absorptiometry absorptiometry NN cord-262892-n38r8n70 253 51 study study NN cord-262892-n38r8n70 253 52 of of IN cord-262892-n38r8n70 253 53 New New NNP cord-262892-n38r8n70 253 54 Zealand Zealand NNP cord-262892-n38r8n70 253 55 girls girl NNS cord-262892-n38r8n70 253 56 and and CC cord-262892-n38r8n70 253 57 young young JJ cord-262892-n38r8n70 253 58 women woman NNS cord-262892-n38r8n70 253 59 European European NNP cord-262892-n38r8n70 253 60 Paediatric Paediatric NNP cord-262892-n38r8n70 253 61 Lipodystrophy Lipodystrophy NNP cord-262892-n38r8n70 253 62 Group Group NNP cord-262892-n38r8n70 253 63 Antiretroviral Antiretroviral NNP cord-262892-n38r8n70 253 64 therapy therapy NN cord-262892-n38r8n70 253 65 , , , cord-262892-n38r8n70 253 66 fat fat JJ cord-262892-n38r8n70 253 67 redistribution redistribution NN cord-262892-n38r8n70 253 68 and and CC cord-262892-n38r8n70 253 69 hyperlipidaemia hyperlipidaemia NN cord-262892-n38r8n70 253 70 in in IN cord-262892-n38r8n70 253 71 HIV HIV NNP cord-262892-n38r8n70 253 72 - - HYPH cord-262892-n38r8n70 253 73 infected infect VBN cord-262892-n38r8n70 253 74 children child NNS cord-262892-n38r8n70 253 75 in in IN cord-262892-n38r8n70 253 76 Europe Europe NNP cord-262892-n38r8n70 253 77 Morphologic Morphologic NNP cord-262892-n38r8n70 253 78 and and CC cord-262892-n38r8n70 253 79 metabolic metabolic JJ cord-262892-n38r8n70 253 80 abnormalities abnormality NNS cord-262892-n38r8n70 253 81 in in IN cord-262892-n38r8n70 253 82 vertically vertically RB cord-262892-n38r8n70 253 83 HIV HIV NNP cord-262892-n38r8n70 253 84 - - HYPH cord-262892-n38r8n70 253 85 infected infect VBN cord-262892-n38r8n70 253 86 children child NNS cord-262892-n38r8n70 253 87 and and CC cord-262892-n38r8n70 253 88 youth youth NN cord-262892-n38r8n70 253 89 Longitudinal longitudinal JJ cord-262892-n38r8n70 253 90 changes change NNS cord-262892-n38r8n70 253 91 in in IN cord-262892-n38r8n70 253 92 regional regional JJ cord-262892-n38r8n70 253 93 fat fat NN cord-262892-n38r8n70 253 94 content content NN cord-262892-n38r8n70 253 95 in in IN cord-262892-n38r8n70 253 96 HIV HIV NNP cord-262892-n38r8n70 253 97 - - HYPH cord-262892-n38r8n70 253 98 infected infect VBN cord-262892-n38r8n70 253 99 children child NNS cord-262892-n38r8n70 253 100 and and CC cord-262892-n38r8n70 253 101 adolescents adolescent NNS cord-262892-n38r8n70 254 1 The the DT cord-262892-n38r8n70 254 2 metabolic metabolic JJ cord-262892-n38r8n70 254 3 syndrome syndrome NN cord-262892-n38r8n70 254 4 in in IN cord-262892-n38r8n70 254 5 HIV HIV NNP cord-262892-n38r8n70 254 6 Predictors Predictors NNP cord-262892-n38r8n70 254 7 of of IN cord-262892-n38r8n70 254 8 bone bone NN cord-262892-n38r8n70 254 9 mineral mineral NN cord-262892-n38r8n70 254 10 density density NN cord-262892-n38r8n70 254 11 in in IN cord-262892-n38r8n70 254 12 human human JJ cord-262892-n38r8n70 254 13 immunodeficiency immunodeficiency NN cord-262892-n38r8n70 254 14 virus-1 virus-1 NN cord-262892-n38r8n70 254 15 infected infect VBN cord-262892-n38r8n70 254 16 children child NNS cord-262892-n38r8n70 255 1 Total total JJ cord-262892-n38r8n70 255 2 body body NN cord-262892-n38r8n70 255 3 and and CC cord-262892-n38r8n70 255 4 spinal spinal JJ cord-262892-n38r8n70 255 5 bone bone NN cord-262892-n38r8n70 255 6 mineral mineral NN cord-262892-n38r8n70 255 7 density density NN cord-262892-n38r8n70 255 8 across across IN cord-262892-n38r8n70 255 9 Tanner Tanner NNP cord-262892-n38r8n70 255 10 stage stage NN cord-262892-n38r8n70 255 11 in in IN cord-262892-n38r8n70 255 12 perinatally perinatally RB cord-262892-n38r8n70 255 13 HIV HIV NNP cord-262892-n38r8n70 255 14 - - HYPH cord-262892-n38r8n70 255 15 infected infect VBN cord-262892-n38r8n70 255 16 and and CC cord-262892-n38r8n70 255 17 uninfected uninfected JJ cord-262892-n38r8n70 255 18 children child NNS cord-262892-n38r8n70 255 19 and and CC cord-262892-n38r8n70 255 20 youth youth NN cord-262892-n38r8n70 255 21 in in IN cord-262892-n38r8n70 255 22 PACTG PACTG NNP cord-262892-n38r8n70 255 23 1045 1045 CD cord-262892-n38r8n70 255 24 Bone Bone NNP cord-262892-n38r8n70 255 25 mineral mineral NN cord-262892-n38r8n70 255 26 loss loss NN cord-262892-n38r8n70 255 27 through through IN cord-262892-n38r8n70 255 28 increased increase VBN cord-262892-n38r8n70 255 29 bone bone NN cord-262892-n38r8n70 255 30 turnover turnover NN cord-262892-n38r8n70 255 31 in in IN cord-262892-n38r8n70 255 32 HIV HIV NNP cord-262892-n38r8n70 255 33 - - HYPH cord-262892-n38r8n70 255 34 infected infect VBN cord-262892-n38r8n70 255 35 children child NNS cord-262892-n38r8n70 255 36 treated treat VBN cord-262892-n38r8n70 255 37 with with IN cord-262892-n38r8n70 255 38 highly highly RB cord-262892-n38r8n70 255 39 active active JJ cord-262892-n38r8n70 255 40 antiretroviral antiretroviral JJ cord-262892-n38r8n70 255 41 therapy therapy NN cord-262892-n38r8n70 255 42 Bone Bone NNP cord-262892-n38r8n70 255 43 mineral mineral NN cord-262892-n38r8n70 255 44 density density NN cord-262892-n38r8n70 255 45 increases increase NNS cord-262892-n38r8n70 255 46 in in IN cord-262892-n38r8n70 255 47 HIV HIV NNP cord-262892-n38r8n70 255 48 - - HYPH cord-262892-n38r8n70 255 49 infected infect VBN cord-262892-n38r8n70 255 50 children child NNS cord-262892-n38r8n70 255 51 treated treat VBN cord-262892-n38r8n70 255 52 with with IN cord-262892-n38r8n70 255 53 longterm longterm JJ cord-262892-n38r8n70 255 54 combination combination NN cord-262892-n38r8n70 255 55 antiretroviral antiretroviral JJ cord-262892-n38r8n70 255 56 therapy therapy NN cord-262892-n38r8n70 255 57 Antiviral antiviral JJ cord-262892-n38r8n70 255 58 therapy therapy NN cord-262892-n38r8n70 255 59 and and CC cord-262892-n38r8n70 255 60 bone bone NN cord-262892-n38r8n70 255 61 mineral mineral NN cord-262892-n38r8n70 255 62 measurements measurement NNS cord-262892-n38r8n70 255 63 in in IN cord-262892-n38r8n70 255 64 HIV HIV NNP cord-262892-n38r8n70 255 65 - - HYPH cord-262892-n38r8n70 255 66 infected infect VBN cord-262892-n38r8n70 255 67 youths youth NNS cord-262892-n38r8n70 255 68 Comparison comparison NN cord-262892-n38r8n70 255 69 of of IN cord-262892-n38r8n70 255 70 changes change NNS cord-262892-n38r8n70 255 71 in in IN cord-262892-n38r8n70 255 72 bone bone NN cord-262892-n38r8n70 255 73 density density NN cord-262892-n38r8n70 255 74 and and CC cord-262892-n38r8n70 255 75 turnover turnover NN cord-262892-n38r8n70 255 76 with with IN cord-262892-n38r8n70 255 77 abacavir abacavir NNP cord-262892-n38r8n70 255 78 - - HYPH cord-262892-n38r8n70 255 79 lamivudine lamivudine NNP cord-262892-n38r8n70 255 80 versus versus IN cord-262892-n38r8n70 255 81 tenofovir tenofovir NNP cord-262892-n38r8n70 255 82 - - HYPH cord-262892-n38r8n70 255 83 emtricitabine emtricitabine NNP cord-262892-n38r8n70 255 84 in in IN cord-262892-n38r8n70 255 85 HIV HIV NNP cord-262892-n38r8n70 255 86 - - HYPH cord-262892-n38r8n70 255 87 infected infect VBN cord-262892-n38r8n70 255 88 adults adult NNS cord-262892-n38r8n70 255 89 : : : cord-262892-n38r8n70 256 1 48-week 48-week CD cord-262892-n38r8n70 256 2 results result NNS cord-262892-n38r8n70 256 3 from from IN cord-262892-n38r8n70 256 4 the the DT cord-262892-n38r8n70 256 5 ASSERT assert NN cord-262892-n38r8n70 256 6 study study NN cord-262892-n38r8n70 256 7 Vitamin vitamin NN cord-262892-n38r8n70 256 8 D d NN cord-262892-n38r8n70 256 9 status status NN cord-262892-n38r8n70 256 10 in in IN cord-262892-n38r8n70 256 11 children child NNS cord-262892-n38r8n70 256 12 and and CC cord-262892-n38r8n70 256 13 young young JJ cord-262892-n38r8n70 256 14 adults adult NNS cord-262892-n38r8n70 256 15 with with IN cord-262892-n38r8n70 256 16 perinatally perinatally RB cord-262892-n38r8n70 256 17 acquired acquire VBD cord-262892-n38r8n70 256 18 HIV HIV NNP cord-262892-n38r8n70 256 19 infection infection NN cord-262892-n38r8n70 256 20 Severe severe JJ cord-262892-n38r8n70 256 21 malnutrition malnutrition NN cord-262892-n38r8n70 256 22 and and CC cord-262892-n38r8n70 256 23 metabolic metabolic JJ cord-262892-n38r8n70 256 24 complications complication NNS cord-262892-n38r8n70 256 25 of of IN cord-262892-n38r8n70 256 26 HIVinfected hivinfecte VBN cord-262892-n38r8n70 256 27 children child NNS cord-262892-n38r8n70 256 28 in in IN cord-262892-n38r8n70 256 29 the the DT cord-262892-n38r8n70 256 30 antiretroviral antiretroviral JJ cord-262892-n38r8n70 256 31 era era NN cord-262892-n38r8n70 256 32 : : : cord-262892-n38r8n70 256 33 clinical clinical JJ cord-262892-n38r8n70 256 34 care care NN cord-262892-n38r8n70 256 35 and and CC cord-262892-n38r8n70 256 36 management management NN cord-262892-n38r8n70 256 37 in in IN cord-262892-n38r8n70 256 38 resourcelimited resourcelimited JJ cord-262892-n38r8n70 256 39 settings setting NNS cord-262892-n38r8n70 256 40 Historical historical JJ cord-262892-n38r8n70 256 41 perspectives perspective NNS cord-262892-n38r8n70 256 42 on on IN cord-262892-n38r8n70 256 43 the the DT cord-262892-n38r8n70 256 44 evolution evolution NN cord-262892-n38r8n70 256 45 in in IN cord-262892-n38r8n70 256 46 understanding understand VBG cord-262892-n38r8n70 256 47 the the DT cord-262892-n38r8n70 256 48 importance importance NN cord-262892-n38r8n70 256 49 of of IN cord-262892-n38r8n70 256 50 nutritional nutritional JJ cord-262892-n38r8n70 256 51 care care NN cord-262892-n38r8n70 256 52 in in IN cord-262892-n38r8n70 256 53 pediatric pediatric JJ cord-262892-n38r8n70 256 54 HIV HIV NNP cord-262892-n38r8n70 256 55 infection infection NN cord-262892-n38r8n70 256 56 Effects effect NNS cord-262892-n38r8n70 256 57 of of IN cord-262892-n38r8n70 256 58 nutritional nutritional JJ cord-262892-n38r8n70 256 59 rehabilitation rehabilitation NN cord-262892-n38r8n70 256 60 on on IN cord-262892-n38r8n70 256 61 intestinal intestinal JJ cord-262892-n38r8n70 256 62 function function NN cord-262892-n38r8n70 256 63 and and CC cord-262892-n38r8n70 256 64 on on IN cord-262892-n38r8n70 256 65 CD4 CD4 NNP cord-262892-n38r8n70 256 66 cell cell NN cord-262892-n38r8n70 256 67 number number NN cord-262892-n38r8n70 256 68 in in IN cord-262892-n38r8n70 256 69 children child NNS cord-262892-n38r8n70 256 70 with with IN cord-262892-n38r8n70 256 71 HIV HIV NNP