id	sid	tid	token	lemma	pos
cord-312955-gs65c3fy	1	1	key	key	JJ
cord-312955-gs65c3fy	2	1	:	:	:
cord-312955-gs65c3fy	2	2	cord-312955-gs65c3fy	cord-312955-gs65c3fy	NNS
cord-312955-gs65c3fy	2	3	authors	author	NNS
cord-312955-gs65c3fy	2	4	:	:	:
cord-312955-gs65c3fy	2	5	Schreiber	Schreiber	NNP
cord-312955-gs65c3fy	2	6	,	,	,
cord-312955-gs65c3fy	2	7	Gideon	Gideon	NNP
cord-312955-gs65c3fy	2	8	title	title	NN
cord-312955-gs65c3fy	2	9	:	:	:
cord-312955-gs65c3fy	2	10	The	the	DT
cord-312955-gs65c3fy	2	11	Role	role	NN
cord-312955-gs65c3fy	2	12	of	of	IN
cord-312955-gs65c3fy	2	13	Type	type	NN
cord-312955-gs65c3fy	2	14	I	-PRON-	PRP
cord-312955-gs65c3fy	2	15	Interferons	Interferons	NNPS
cord-312955-gs65c3fy	2	16	in	in	IN
cord-312955-gs65c3fy	2	17	the	the	DT
cord-312955-gs65c3fy	2	18	Pathogenesis	Pathogenesis	NNP
cord-312955-gs65c3fy	2	19	and	and	CC
cord-312955-gs65c3fy	2	20	Treatment	Treatment	NNP
cord-312955-gs65c3fy	2	21	of	of	IN
cord-312955-gs65c3fy	2	22	COVID-19	covid-19	CD
cord-312955-gs65c3fy	2	23	date	date	NN
cord-312955-gs65c3fy	2	24	:	:	:
cord-312955-gs65c3fy	2	25	2020	2020	CD
cord-312955-gs65c3fy	2	26	-	-	HYPH
cord-312955-gs65c3fy	2	27	09	09	CD
cord-312955-gs65c3fy	2	28	-	-	SYM
cord-312955-gs65c3fy	2	29	30	30	CD
cord-312955-gs65c3fy	2	30	journal	journal	NN
cord-312955-gs65c3fy	2	31	:	:	:
cord-312955-gs65c3fy	3	1	Front	Front	NNP
cord-312955-gs65c3fy	3	2	Immunol	Immunol	NNP
cord-312955-gs65c3fy	3	3	DOI	doi	NN
cord-312955-gs65c3fy	3	4	:	:	:
cord-312955-gs65c3fy	4	1	10.3389	10.3389	CD
cord-312955-gs65c3fy	5	1	/fimmu.2020.595739	/fimmu.2020.595739	NFP
cord-312955-gs65c3fy	5	2	sha	sha	NNP
cord-312955-gs65c3fy	5	3	:	:	:
cord-312955-gs65c3fy	6	1	dd43ec3dc82c677156610509d0bc7a0ef954174b	dd43ec3dc82c677156610509d0bc7a0ef954174b	NNP
cord-312955-gs65c3fy	6	2	doc_id	doc_id	CD
cord-312955-gs65c3fy	6	3	:	:	:
cord-312955-gs65c3fy	6	4	312955	312955	CD
cord-312955-gs65c3fy	6	5	cord_uid	cord_uid	NNS
cord-312955-gs65c3fy	6	6	:	:	:
cord-312955-gs65c3fy	7	1	gs65c3fy	gs65c3fy	NNP
cord-312955-gs65c3fy	8	1	Type	type	NN
cord-312955-gs65c3fy	8	2	I	-PRON-	PRP
cord-312955-gs65c3fy	8	3	interferons	interferon	NNS
cord-312955-gs65c3fy	8	4	(	(	-LRB-
cord-312955-gs65c3fy	8	5	IFN	IFN	NNP
cord-312955-gs65c3fy	8	6	-	-	HYPH
cord-312955-gs65c3fy	8	7	I	I	NNP
cord-312955-gs65c3fy	8	8	)	)	-RRB-
cord-312955-gs65c3fy	8	9	were	be	VBD
cord-312955-gs65c3fy	8	10	first	first	RB
cord-312955-gs65c3fy	8	11	discovered	discover	VBN
cord-312955-gs65c3fy	8	12	over	over	IN
cord-312955-gs65c3fy	8	13	60	60	CD
cord-312955-gs65c3fy	8	14	years	year	NNS
cord-312955-gs65c3fy	8	15	ago	ago	RB
cord-312955-gs65c3fy	8	16	in	in	IN
cord-312955-gs65c3fy	8	17	a	a	DT
cord-312955-gs65c3fy	8	18	classical	classical	JJ
cord-312955-gs65c3fy	8	19	experiment	experiment	NN
cord-312955-gs65c3fy	8	20	by	by	IN
cord-312955-gs65c3fy	8	21	Isaacs	Isaacs	NNP
cord-312955-gs65c3fy	8	22	and	and	CC
cord-312955-gs65c3fy	8	23	Lindenman	Lindenman	NNP
cord-312955-gs65c3fy	8	24	,	,	,
cord-312955-gs65c3fy	8	25	who	who	WP
cord-312955-gs65c3fy	8	26	showed	show	VBD
cord-312955-gs65c3fy	8	27	that	that	IN
cord-312955-gs65c3fy	8	28	IFN	IFN	NNP
cord-312955-gs65c3fy	8	29	-	-	:
cord-312955-gs65c3fy	8	30	Is	be	VBZ
cord-312955-gs65c3fy	8	31	possess	possess	VB
cord-312955-gs65c3fy	8	32	antiviral	antiviral	JJ
cord-312955-gs65c3fy	8	33	activity	activity	NN
cord-312955-gs65c3fy	8	34	.	.	.
cord-312955-gs65c3fy	9	1	Later	later	RB
cord-312955-gs65c3fy	9	2	,	,	,
cord-312955-gs65c3fy	9	3	it	-PRON-	PRP
cord-312955-gs65c3fy	9	4	became	become	VBD
cord-312955-gs65c3fy	9	5	one	one	CD
cord-312955-gs65c3fy	9	6	of	of	IN
cord-312955-gs65c3fy	9	7	the	the	DT
cord-312955-gs65c3fy	9	8	first	first	JJ
cord-312955-gs65c3fy	9	9	approved	approve	VBN
cord-312955-gs65c3fy	9	10	protein	protein	NN
cord-312955-gs65c3fy	9	11	drugs	drug	NNS
cord-312955-gs65c3fy	9	12	using	use	VBG
cord-312955-gs65c3fy	9	13	heterologous	heterologous	JJ
cord-312955-gs65c3fy	9	14	protein	protein	NN
cord-312955-gs65c3fy	9	15	expression	expression	NN
cord-312955-gs65c3fy	9	16	systems	system	NNS
cord-312955-gs65c3fy	9	17	,	,	,
cord-312955-gs65c3fy	9	18	which	which	WDT
cord-312955-gs65c3fy	9	19	allowed	allow	VBD
cord-312955-gs65c3fy	9	20	its	-PRON-	PRP$
cord-312955-gs65c3fy	9	21	large	large	JJ
cord-312955-gs65c3fy	9	22	-	-	HYPH
cord-312955-gs65c3fy	9	23	scale	scale	NN
cord-312955-gs65c3fy	9	24	production	production	NN
cord-312955-gs65c3fy	9	25	.	.	.
cord-312955-gs65c3fy	10	1	It	-PRON-	PRP
cord-312955-gs65c3fy	10	2	has	have	VBZ
cord-312955-gs65c3fy	10	3	been	be	VBN
cord-312955-gs65c3fy	10	4	approved	approve	VBN
cord-312955-gs65c3fy	10	5	,	,	,
cord-312955-gs65c3fy	10	6	and	and	CC
cord-312955-gs65c3fy	10	7	widely	widely	RB
cord-312955-gs65c3fy	10	8	used	use	VBN
cord-312955-gs65c3fy	10	9	in	in	IN
cord-312955-gs65c3fy	10	10	a	a	DT
cord-312955-gs65c3fy	10	11	pleiotropy	pleiotropy	NN
cord-312955-gs65c3fy	10	12	of	of	IN
cord-312955-gs65c3fy	10	13	diseases	disease	NNS
cord-312955-gs65c3fy	10	14	,	,	,
cord-312955-gs65c3fy	10	15	including	include	VBG
cord-312955-gs65c3fy	10	16	multiple	multiple	JJ
cord-312955-gs65c3fy	10	17	-	-	HYPH
cord-312955-gs65c3fy	10	18	sclerosis	sclerosis	NN
cord-312955-gs65c3fy	10	19	,	,	,
cord-312955-gs65c3fy	10	20	hepatitis	hepatitis	NNP
cord-312955-gs65c3fy	10	21	B	B	NNP
cord-312955-gs65c3fy	10	22	and	and	CC
cord-312955-gs65c3fy	10	23	C	C	NNP
cord-312955-gs65c3fy	10	24	,	,	,
cord-312955-gs65c3fy	10	25	and	and	CC
cord-312955-gs65c3fy	10	26	some	some	DT
cord-312955-gs65c3fy	10	27	forms	form	NNS
cord-312955-gs65c3fy	10	28	of	of	IN
cord-312955-gs65c3fy	10	29	cancer	cancer	NN
cord-312955-gs65c3fy	10	30	.	.	.
cord-312955-gs65c3fy	11	1	Preliminary	preliminary	JJ
cord-312955-gs65c3fy	11	2	clinical	clinical	JJ
cord-312955-gs65c3fy	11	3	data	datum	NNS
cord-312955-gs65c3fy	11	4	has	have	VBZ
cord-312955-gs65c3fy	11	5	supported	support	VBN
cord-312955-gs65c3fy	11	6	its	-PRON-	PRP$
cord-312955-gs65c3fy	11	7	effectiveness	effectiveness	NN
cord-312955-gs65c3fy	11	8	against	against	IN
cord-312955-gs65c3fy	11	9	potential	potential	JJ
cord-312955-gs65c3fy	11	10	pandemic	pandemic	NN
cord-312955-gs65c3fy	11	11	pathogens	pathogen	NNS
cord-312955-gs65c3fy	11	12	such	such	JJ
cord-312955-gs65c3fy	11	13	as	as	IN
cord-312955-gs65c3fy	11	14	Ebola	Ebola	NNP
cord-312955-gs65c3fy	11	15	and	and	CC
cord-312955-gs65c3fy	11	16	SARS	SARS	NNP
cord-312955-gs65c3fy	11	17	.	.	.
cord-312955-gs65c3fy	12	1	Still	still	RB
cord-312955-gs65c3fy	12	2	,	,	,
cord-312955-gs65c3fy	12	3	more	more	RBR
cord-312955-gs65c3fy	12	4	efficient	efficient	JJ
cord-312955-gs65c3fy	12	5	and	and	CC
cord-312955-gs65c3fy	12	6	specific	specific	JJ
cord-312955-gs65c3fy	12	7	drugs	drug	NNS
cord-312955-gs65c3fy	12	8	have	have	VBP
cord-312955-gs65c3fy	12	9	taken	take	VBN
cord-312955-gs65c3fy	12	10	its	-PRON-	PRP$
cord-312955-gs65c3fy	12	11	place	place	NN
cord-312955-gs65c3fy	12	12	in	in	IN
cord-312955-gs65c3fy	12	13	treating	treat	VBG
cord-312955-gs65c3fy	12	14	such	such	JJ
cord-312955-gs65c3fy	12	15	diseases	disease	NNS
cord-312955-gs65c3fy	12	16	.	.	.
cord-312955-gs65c3fy	13	1	The	the	DT
cord-312955-gs65c3fy	13	2	COVID-19	covid-19	JJ
cord-312955-gs65c3fy	13	3	global	global	JJ
cord-312955-gs65c3fy	13	4	pandemic	pandemic	NN
cord-312955-gs65c3fy	13	5	has	have	VBZ
cord-312955-gs65c3fy	13	6	again	again	RB
cord-312955-gs65c3fy	13	7	lifted	lift	VBN
cord-312955-gs65c3fy	13	8	the	the	DT
cord-312955-gs65c3fy	13	9	status	status	NN
cord-312955-gs65c3fy	13	10	of	of	IN
cord-312955-gs65c3fy	13	11	IFN	IFN	NNP
cord-312955-gs65c3fy	13	12	-	-	,
cord-312955-gs65c3fy	13	13	Is	be	VBZ
cord-312955-gs65c3fy	13	14	to	to	TO
cord-312955-gs65c3fy	13	15	become	become	VB
cord-312955-gs65c3fy	13	16	one	one	CD
cord-312955-gs65c3fy	13	17	of	of	IN
cord-312955-gs65c3fy	13	18	the	the	DT
cord-312955-gs65c3fy	13	19	more	more	RBR
cord-312955-gs65c3fy	13	20	promising	promising	JJ
cord-312955-gs65c3fy	13	21	drug	drug	NN
cord-312955-gs65c3fy	13	22	candidates	candidate	NNS
cord-312955-gs65c3fy	13	23	,	,	,
cord-312955-gs65c3fy	13	24	with	with	IN
cord-312955-gs65c3fy	13	25	initial	initial	JJ
cord-312955-gs65c3fy	13	26	clinical	clinical	JJ
cord-312955-gs65c3fy	13	27	trials	trial	NNS
cord-312955-gs65c3fy	13	28	showing	show	VBG
cord-312955-gs65c3fy	13	29	promising	promising	JJ
cord-312955-gs65c3fy	13	30	results	result	NNS
cord-312955-gs65c3fy	13	31	in	in	IN
cord-312955-gs65c3fy	13	32	reducing	reduce	VBG
cord-312955-gs65c3fy	13	33	the	the	DT
cord-312955-gs65c3fy	13	34	severity	severity	NN
cord-312955-gs65c3fy	13	35	and	and	CC
cord-312955-gs65c3fy	13	36	duration	duration	NN
cord-312955-gs65c3fy	13	37	of	of	IN
cord-312955-gs65c3fy	13	38	the	the	DT
cord-312955-gs65c3fy	13	39	disease	disease	NN
cord-312955-gs65c3fy	13	40	.	.	.
cord-312955-gs65c3fy	14	1	Although	although	IN
cord-312955-gs65c3fy	14	2	SARS	SARS	NNP
cord-312955-gs65c3fy	14	3	-	-	HYPH
cord-312955-gs65c3fy	14	4	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	14	5	inhibits	inhibit	VBZ
cord-312955-gs65c3fy	14	6	the	the	DT
cord-312955-gs65c3fy	14	7	production	production	NN
cord-312955-gs65c3fy	14	8	of	of	IN
cord-312955-gs65c3fy	14	9	IFNβ	IFNβ	NNS
cord-312955-gs65c3fy	14	10	and	and	CC
cord-312955-gs65c3fy	14	11	thus	thus	RB
cord-312955-gs65c3fy	14	12	obstructs	obstruct	VBZ
cord-312955-gs65c3fy	14	13	the	the	DT
cord-312955-gs65c3fy	14	14	innate	innate	JJ
cord-312955-gs65c3fy	14	15	immune	immune	JJ
cord-312955-gs65c3fy	14	16	response	response	NN
cord-312955-gs65c3fy	14	17	to	to	IN
cord-312955-gs65c3fy	14	18	this	this	DT
cord-312955-gs65c3fy	14	19	virus	virus	NN
cord-312955-gs65c3fy	14	20	,	,	,
cord-312955-gs65c3fy	14	21	it	-PRON-	PRP
cord-312955-gs65c3fy	14	22	is	be	VBZ
cord-312955-gs65c3fy	14	23	sensitive	sensitive	JJ
cord-312955-gs65c3fy	14	24	to	to	IN
cord-312955-gs65c3fy	14	25	the	the	DT
cord-312955-gs65c3fy	14	26	antiviral	antiviral	JJ
cord-312955-gs65c3fy	14	27	activity	activity	NN
cord-312955-gs65c3fy	14	28	of	of	IN
cord-312955-gs65c3fy	14	29	externally	externally	RB
cord-312955-gs65c3fy	14	30	administrated	administrate	VBN
cord-312955-gs65c3fy	14	31	IFN	IFN	NNP
cord-312955-gs65c3fy	14	32	-	-	HYPH
cord-312955-gs65c3fy	14	33	Is	be	VBZ
cord-312955-gs65c3fy	14	34	.	.	.
cord-312955-gs65c3fy	15	1	In	in	IN
cord-312955-gs65c3fy	15	2	this	this	DT
cord-312955-gs65c3fy	15	3	review	review	NN
cord-312955-gs65c3fy	15	4	I	-PRON-	PRP
cord-312955-gs65c3fy	15	5	discuss	discuss	VBP
cord-312955-gs65c3fy	15	6	the	the	DT
cord-312955-gs65c3fy	15	7	diverse	diverse	JJ
cord-312955-gs65c3fy	15	8	modes	mode	NNS
cord-312955-gs65c3fy	15	9	of	of	IN
cord-312955-gs65c3fy	15	10	biological	biological	JJ
cord-312955-gs65c3fy	15	11	actions	action	NNS
cord-312955-gs65c3fy	15	12	of	of	IN
cord-312955-gs65c3fy	15	13	IFN	IFN	NNP
cord-312955-gs65c3fy	15	14	-	-	,
cord-312955-gs65c3fy	15	15	Is	be	VBZ
cord-312955-gs65c3fy	15	16	and	and	CC
cord-312955-gs65c3fy	15	17	how	how	WRB
cord-312955-gs65c3fy	15	18	these	these	DT
cord-312955-gs65c3fy	15	19	are	be	VBP
cord-312955-gs65c3fy	15	20	related	relate	VBN
cord-312955-gs65c3fy	15	21	to	to	IN
cord-312955-gs65c3fy	15	22	biophysical	biophysical	JJ
cord-312955-gs65c3fy	15	23	parameters	parameter	NNS
cord-312955-gs65c3fy	15	24	of	of	IN
cord-312955-gs65c3fy	15	25	IFN	IFN	NNP
cord-312955-gs65c3fy	15	26	-	-	HYPH
cord-312955-gs65c3fy	15	27	I	I	NNP
cord-312955-gs65c3fy	15	28	–	–	:
cord-312955-gs65c3fy	15	29	receptor	receptor	NN
cord-312955-gs65c3fy	15	30	interaction	interaction	NN
cord-312955-gs65c3fy	15	31	and	and	CC
cord-312955-gs65c3fy	15	32	cell	cell	NN
cord-312955-gs65c3fy	15	33	-	-	HYPH
cord-312955-gs65c3fy	15	34	type	type	NN
cord-312955-gs65c3fy	15	35	specificity	specificity	NN
cord-312955-gs65c3fy	15	36	in	in	IN
cord-312955-gs65c3fy	15	37	light	light	NN
cord-312955-gs65c3fy	15	38	of	of	IN
cord-312955-gs65c3fy	15	39	the	the	DT
cord-312955-gs65c3fy	15	40	large	large	JJ
cord-312955-gs65c3fy	15	41	variety	variety	NN
cord-312955-gs65c3fy	15	42	of	of	IN
cord-312955-gs65c3fy	15	43	binding	bind	VBG
cord-312955-gs65c3fy	15	44	affinities	affinity	NNS
cord-312955-gs65c3fy	15	45	of	of	IN
cord-312955-gs65c3fy	15	46	the	the	DT
cord-312955-gs65c3fy	15	47	different	different	JJ
cord-312955-gs65c3fy	15	48	IFN	IFN	NNP
cord-312955-gs65c3fy	15	49	-	-	HYPH
cord-312955-gs65c3fy	15	50	I	-PRON-	PRP
cord-312955-gs65c3fy	15	51	subtypes	subtype	NNS
cord-312955-gs65c3fy	15	52	towards	towards	IN
cord-312955-gs65c3fy	15	53	the	the	DT
cord-312955-gs65c3fy	15	54	common	common	JJ
cord-312955-gs65c3fy	15	55	interferon	interferon	NN
cord-312955-gs65c3fy	15	56	receptor	receptor	NN
cord-312955-gs65c3fy	15	57	.	.	.
cord-312955-gs65c3fy	16	1	Furthermore	furthermore	RB
cord-312955-gs65c3fy	16	2	,	,	,
cord-312955-gs65c3fy	16	3	I	-PRON-	PRP
cord-312955-gs65c3fy	16	4	discuss	discuss	VBP
cord-312955-gs65c3fy	16	5	how	how	WRB
cord-312955-gs65c3fy	16	6	these	these	DT
cord-312955-gs65c3fy	16	7	may	may	MD
cord-312955-gs65c3fy	16	8	guide	guide	VB
cord-312955-gs65c3fy	16	9	the	the	DT
cord-312955-gs65c3fy	16	10	optimized	optimize	VBN
cord-312955-gs65c3fy	16	11	use	use	NN
cord-312955-gs65c3fy	16	12	IFN	IFN	NNP
cord-312955-gs65c3fy	16	13	-	-	,
cord-312955-gs65c3fy	16	14	Is	be	VBZ
cord-312955-gs65c3fy	16	15	in	in	IN
cord-312955-gs65c3fy	16	16	combatting	combat	VBG
cord-312955-gs65c3fy	16	17	COVID-19	covid-19	NN
cord-312955-gs65c3fy	16	18	.	.	.
cord-312955-gs65c3fy	17	1	Type	type	NN
cord-312955-gs65c3fy	17	2	I	-PRON-	PRP
cord-312955-gs65c3fy	17	3	interferons	interferon	NNS
cord-312955-gs65c3fy	17	4	(	(	-LRB-
cord-312955-gs65c3fy	17	5	IFN	IFN	NNP
cord-312955-gs65c3fy	17	6	-	-	HYPH
cord-312955-gs65c3fy	17	7	I	I	NNP
cord-312955-gs65c3fy	17	8	)	)	-RRB-
cord-312955-gs65c3fy	17	9	are	be	VBP
cord-312955-gs65c3fy	17	10	a	a	DT
cord-312955-gs65c3fy	17	11	family	family	NN
cord-312955-gs65c3fy	17	12	of	of	IN
cord-312955-gs65c3fy	17	13	cytokines	cytokine	NNS
cord-312955-gs65c3fy	17	14	that	that	WDT
cord-312955-gs65c3fy	17	15	bind	bind	VBP
cord-312955-gs65c3fy	17	16	the	the	DT
cord-312955-gs65c3fy	17	17	type	type	NN
cord-312955-gs65c3fy	18	1	I	-PRON-	PRP
cord-312955-gs65c3fy	18	2	interferon	interferon	VBD
cord-312955-gs65c3fy	18	3	receptor	receptor	NN
cord-312955-gs65c3fy	18	4	,	,	,
cord-312955-gs65c3fy	18	5	constituted	constitute	VBN
cord-312955-gs65c3fy	18	6	of	of	IN
cord-312955-gs65c3fy	18	7	two	two	CD
cord-312955-gs65c3fy	18	8	transmembrane	transmembrane	NN
cord-312955-gs65c3fy	18	9	subunits	subunit	NNS
cord-312955-gs65c3fy	18	10	,	,	,
cord-312955-gs65c3fy	18	11	IFNAR1	ifnar1	NN
cord-312955-gs65c3fy	18	12	and	and	CC
cord-312955-gs65c3fy	18	13	IFNAR2	IFNAR2	NNP
cord-312955-gs65c3fy	19	1	(	(	-LRB-
cord-312955-gs65c3fy	19	2	Figure	figure	NN
cord-312955-gs65c3fy	19	3	1	1	CD
cord-312955-gs65c3fy	19	4	)	)	-RRB-
cord-312955-gs65c3fy	19	5	.	.	.
cord-312955-gs65c3fy	20	1	The	the	DT
cord-312955-gs65c3fy	20	2	two	two	CD
cord-312955-gs65c3fy	20	3	receptors	receptor	NNS
cord-312955-gs65c3fy	20	4	are	be	VBP
cord-312955-gs65c3fy	20	5	constituted	constitute	VBN
cord-312955-gs65c3fy	20	6	of	of	IN
cord-312955-gs65c3fy	20	7	an	an	DT
cord-312955-gs65c3fy	20	8	extracellular	extracellular	JJ
cord-312955-gs65c3fy	20	9	domain	domain	NN
cord-312955-gs65c3fy	20	10	,	,	,
cord-312955-gs65c3fy	20	11	which	which	WDT
cord-312955-gs65c3fy	20	12	binds	bind	VBZ
cord-312955-gs65c3fy	20	13	IFN	IFN	NNP
cord-312955-gs65c3fy	20	14	-	-	HYPH
cord-312955-gs65c3fy	20	15	I	I	NNP
cord-312955-gs65c3fy	20	16	,	,	,
cord-312955-gs65c3fy	20	17	a	a	DT
cord-312955-gs65c3fy	20	18	transmembrane	transmembrane	NN
cord-312955-gs65c3fy	20	19	helix	helix	NN
cord-312955-gs65c3fy	20	20	and	and	CC
cord-312955-gs65c3fy	20	21	an	an	DT
cord-312955-gs65c3fy	20	22	unstructured	unstructured	JJ
cord-312955-gs65c3fy	20	23	intracellular	intracellular	JJ
cord-312955-gs65c3fy	20	24	domain	domain	NN
cord-312955-gs65c3fy	20	25	(	(	-LRB-
cord-312955-gs65c3fy	20	26	ICD	ICD	NNP
cord-312955-gs65c3fy	20	27	)	)	-RRB-
cord-312955-gs65c3fy	20	28	that	that	WDT
cord-312955-gs65c3fy	20	29	binds	bind	VBZ
cord-312955-gs65c3fy	20	30	JAKs	jak	NNS
cord-312955-gs65c3fy	20	31	and	and	CC
cord-312955-gs65c3fy	20	32	STATs	stat	NNS
cord-312955-gs65c3fy	20	33	(	(	-LRB-
cord-312955-gs65c3fy	20	34	1	1	CD
cord-312955-gs65c3fy	20	35	,	,	,
cord-312955-gs65c3fy	20	36	2	2	CD
cord-312955-gs65c3fy	20	37	)	)	-RRB-
cord-312955-gs65c3fy	20	38	.	.	.
cord-312955-gs65c3fy	21	1	JAK1	JAK1	NNP
cord-312955-gs65c3fy	21	2	is	be	VBZ
cord-312955-gs65c3fy	21	3	associated	associate	VBN
cord-312955-gs65c3fy	21	4	with	with	IN
cord-312955-gs65c3fy	21	5	IFNAR2	IFNAR2	NNS
cord-312955-gs65c3fy	21	6	and	and	CC
cord-312955-gs65c3fy	21	7	TYK2	TYK2	NNP
cord-312955-gs65c3fy	21	8	with	with	IN
cord-312955-gs65c3fy	21	9	IFNAR1	ifnar1	NN
cord-312955-gs65c3fy	21	10	.	.	.
cord-312955-gs65c3fy	22	1	STAT1	stat1	XX
cord-312955-gs65c3fy	23	1	and	and	CC
cord-312955-gs65c3fy	23	2	STAT2	STAT2	NNS
cord-312955-gs65c3fy	24	1	(	(	-LRB-
cord-312955-gs65c3fy	24	2	and	and	CC
cord-312955-gs65c3fy	24	3	maybe	maybe	RB
cord-312955-gs65c3fy	24	4	also	also	RB
cord-312955-gs65c3fy	24	5	other	other	JJ
cord-312955-gs65c3fy	24	6	STATs	stat	NNS
cord-312955-gs65c3fy	24	7	)	)	-RRB-
cord-312955-gs65c3fy	24	8	were	be	VBD
cord-312955-gs65c3fy	24	9	found	find	VBN
cord-312955-gs65c3fy	24	10	to	to	TO
cord-312955-gs65c3fy	24	11	be	be	VB
cord-312955-gs65c3fy	24	12	constitutively	constitutively	RB
cord-312955-gs65c3fy	24	13	bound	bind	VBN
cord-312955-gs65c3fy	24	14	to	to	IN
cord-312955-gs65c3fy	24	15	the	the	DT
cord-312955-gs65c3fy	24	16	ICD	ICD	NNP
cord-312955-gs65c3fy	24	17	of	of	IN
cord-312955-gs65c3fy	24	18	IFNAR2	IFNAR2	NNP
cord-312955-gs65c3fy	25	1	(	(	-LRB-
cord-312955-gs65c3fy	25	2	3	3	LS
cord-312955-gs65c3fy	25	3	)	)	-RRB-
cord-312955-gs65c3fy	25	4	(	(	-LRB-
cord-312955-gs65c3fy	25	5	4	4	LS
cord-312955-gs65c3fy	25	6	)	)	-RRB-
cord-312955-gs65c3fy	25	7	(	(	-LRB-
cord-312955-gs65c3fy	25	8	5	5	CD
cord-312955-gs65c3fy	25	9	)	)	-RRB-
cord-312955-gs65c3fy	25	10	.	.	.
cord-312955-gs65c3fy	26	1	Binding	bind	VBG
cord-312955-gs65c3fy	26	2	results	result	NNS
cord-312955-gs65c3fy	26	3	in	in	IN
cord-312955-gs65c3fy	26	4	close	close	JJ
cord-312955-gs65c3fy	26	5	proximity	proximity	NN
cord-312955-gs65c3fy	26	6	of	of	IN
cord-312955-gs65c3fy	26	7	the	the	DT
cord-312955-gs65c3fy	26	8	intracellularly	intracellularly	NNP
cord-312955-gs65c3fy	26	9	associated	associate	VBN
cord-312955-gs65c3fy	26	10	JAKs	jak	NNS
cord-312955-gs65c3fy	26	11	,	,	,
cord-312955-gs65c3fy	26	12	JAK1	JAK1	NNP
cord-312955-gs65c3fy	26	13	and	and	CC
cord-312955-gs65c3fy	26	14	TYK2	TYK2	NNP
cord-312955-gs65c3fy	26	15	,	,	,
cord-312955-gs65c3fy	26	16	resulting	result	VBG
cord-312955-gs65c3fy	26	17	in	in	IN
cord-312955-gs65c3fy	26	18	their	-PRON-	PRP$
cord-312955-gs65c3fy	26	19	activation	activation	NN
cord-312955-gs65c3fy	26	20	through	through	IN
cord-312955-gs65c3fy	26	21	cross	cross	NN
cord-312955-gs65c3fy	26	22	phosphorylation	phosphorylation	NN
cord-312955-gs65c3fy	26	23	(	(	-LRB-
cord-312955-gs65c3fy	26	24	Figure	figure	NN
cord-312955-gs65c3fy	26	25	1	1	CD
cord-312955-gs65c3fy	26	26	)	)	-RRB-
cord-312955-gs65c3fy	26	27	(	(	-LRB-
cord-312955-gs65c3fy	26	28	6	6	CD
cord-312955-gs65c3fy	26	29	,	,	,
cord-312955-gs65c3fy	26	30	7	7	CD
cord-312955-gs65c3fy	26	31	)	)	-RRB-
cord-312955-gs65c3fy	26	32	.	.	.
cord-312955-gs65c3fy	27	1	This	this	DT
cord-312955-gs65c3fy	27	2	also	also	RB
cord-312955-gs65c3fy	27	3	results	result	VBZ
cord-312955-gs65c3fy	27	4	in	in	IN
cord-312955-gs65c3fy	27	5	receptor	receptor	NN
cord-312955-gs65c3fy	27	6	phosphorylation	phosphorylation	NN
cord-312955-gs65c3fy	27	7	,	,	,
cord-312955-gs65c3fy	27	8	which	which	WDT
cord-312955-gs65c3fy	27	9	role	role	NN
cord-312955-gs65c3fy	27	10	is	be	VBZ
cord-312955-gs65c3fy	27	11	still	still	RB
cord-312955-gs65c3fy	27	12	under	under	IN
cord-312955-gs65c3fy	27	13	debate	debate	NN
cord-312955-gs65c3fy	27	14	(	(	-LRB-
cord-312955-gs65c3fy	27	15	3	3	CD
cord-312955-gs65c3fy	27	16	,	,	,
cord-312955-gs65c3fy	27	17	(	(	-LRB-
cord-312955-gs65c3fy	27	18	8)	8)	NNP
cord-312955-gs65c3fy	27	19	(	(	-LRB-
cord-312955-gs65c3fy	27	20	9	9	CD
cord-312955-gs65c3fy	27	21	)	)	-RRB-
cord-312955-gs65c3fy	27	22	(	(	-LRB-
cord-312955-gs65c3fy	27	23	10	10	CD
cord-312955-gs65c3fy	27	24	)	)	-RRB-
cord-312955-gs65c3fy	27	25	.	.	.
cord-312955-gs65c3fy	28	1	The	the	DT
cord-312955-gs65c3fy	28	2	phosphorylated	phosphorylated	JJ
cord-312955-gs65c3fy	28	3	STATs	stat	NNS
cord-312955-gs65c3fy	28	4	dissociate	dissociate	VBP
cord-312955-gs65c3fy	28	5	from	from	IN
cord-312955-gs65c3fy	28	6	the	the	DT
cord-312955-gs65c3fy	28	7	receptor	receptor	NN
cord-312955-gs65c3fy	28	8	and	and	CC
cord-312955-gs65c3fy	28	9	form	form	VB
cord-312955-gs65c3fy	28	10	homo	homo	NN
cord-312955-gs65c3fy	28	11	and	and	CC
cord-312955-gs65c3fy	28	12	hetero	hetero	JJ
cord-312955-gs65c3fy	28	13	dimers	dimer	NNS
cord-312955-gs65c3fy	28	14	,	,	,
cord-312955-gs65c3fy	28	15	which	which	WDT
cord-312955-gs65c3fy	28	16	are	be	VBP
cord-312955-gs65c3fy	28	17	transported	transport	VBN
cord-312955-gs65c3fy	28	18	to	to	IN
cord-312955-gs65c3fy	28	19	the	the	DT
cord-312955-gs65c3fy	28	20	nucleus	nucleus	NN
cord-312955-gs65c3fy	28	21	,	,	,
cord-312955-gs65c3fy	28	22	where	where	WRB
cord-312955-gs65c3fy	28	23	they	-PRON-	PRP
cord-312955-gs65c3fy	28	24	serve	serve	VBP
cord-312955-gs65c3fy	28	25	as	as	IN
cord-312955-gs65c3fy	28	26	transcription	transcription	NN
cord-312955-gs65c3fy	28	27	factors	factor	NNS
cord-312955-gs65c3fy	28	28	for	for	IN
cord-312955-gs65c3fy	28	29	a	a	DT
cord-312955-gs65c3fy	28	30	large	large	JJ
cord-312955-gs65c3fy	28	31	number	number	NN
cord-312955-gs65c3fy	28	32	of	of	IN
cord-312955-gs65c3fy	28	33	genes	gene	NNS
cord-312955-gs65c3fy	28	34	.	.	.
cord-312955-gs65c3fy	29	1	The	the	DT
cord-312955-gs65c3fy	29	2	most	most	RBS
cord-312955-gs65c3fy	29	3	prominent	prominent	JJ
cord-312955-gs65c3fy	29	4	effects	effect	NNS
cord-312955-gs65c3fy	29	5	are	be	VBP
cord-312955-gs65c3fy	29	6	associated	associate	VBN
cord-312955-gs65c3fy	29	7	with	with	IN
cord-312955-gs65c3fy	29	8	STAT1	stat1	NN
cord-312955-gs65c3fy	29	9	/	/	SYM
cord-312955-gs65c3fy	29	10	STAT2	STAT2	NNS
cord-312955-gs65c3fy	29	11	heterodimerization	heterodimerization	NN
cord-312955-gs65c3fy	29	12	,	,	,
cord-312955-gs65c3fy	29	13	which	which	WDT
cord-312955-gs65c3fy	29	14	together	together	RB
cord-312955-gs65c3fy	29	15	with	with	IN
cord-312955-gs65c3fy	29	16	IRF9	IRF9	NNP
cord-312955-gs65c3fy	29	17	form	form	NN
cord-312955-gs65c3fy	29	18	the	the	DT
cord-312955-gs65c3fy	29	19	interferon	interferon	NN
cord-312955-gs65c3fy	29	20	-	-	HYPH
cord-312955-gs65c3fy	29	21	stimulated	stimulate	VBN
cord-312955-gs65c3fy	29	22	gene	gene	NN
cord-312955-gs65c3fy	29	23	factor	factor	NN
cord-312955-gs65c3fy	29	24	3	3	CD
cord-312955-gs65c3fy	29	25	(	(	-LRB-
cord-312955-gs65c3fy	29	26	ISGF3	ISGF3	NNP
cord-312955-gs65c3fy	29	27	)	)	-RRB-
cord-312955-gs65c3fy	29	28	,	,	,
cord-312955-gs65c3fy	29	29	which	which	WDT
cord-312955-gs65c3fy	29	30	bind	bind	VBP
cord-312955-gs65c3fy	29	31	a	a	DT
cord-312955-gs65c3fy	29	32	distinct	distinct	JJ
cord-312955-gs65c3fy	29	33	group	group	NN
cord-312955-gs65c3fy	29	34	of	of	IN
cord-312955-gs65c3fy	29	35	target	target	NN
cord-312955-gs65c3fy	29	36	genes	gene	NNS
cord-312955-gs65c3fy	29	37	harboring	harbor	VBG
cord-312955-gs65c3fy	29	38	the	the	DT
cord-312955-gs65c3fy	29	39	interferonstimulated	interferonstimulate	VBN
cord-312955-gs65c3fy	29	40	response	response	NN
cord-312955-gs65c3fy	29	41	elements	element	NNS
cord-312955-gs65c3fy	29	42	(	(	-LRB-
cord-312955-gs65c3fy	29	43	ISRE	ISRE	NNP
cord-312955-gs65c3fy	29	44	)	)	-RRB-
cord-312955-gs65c3fy	29	45	.	.	.
cord-312955-gs65c3fy	30	1	In	in	IN
cord-312955-gs65c3fy	30	2	addition	addition	NN
cord-312955-gs65c3fy	30	3	to	to	IN
cord-312955-gs65c3fy	30	4	this	this	DT
cord-312955-gs65c3fy	30	5	,	,	,
cord-312955-gs65c3fy	30	6	IFN	IFN	NNP
cord-312955-gs65c3fy	30	7	-	-	HYPH
cord-312955-gs65c3fy	30	8	I	-PRON-	PRP
cord-312955-gs65c3fy	30	9	drives	drive	VBZ
cord-312955-gs65c3fy	30	10	STAT1	stat1	VB
cord-312955-gs65c3fy	30	11	/	/	SYM
cord-312955-gs65c3fy	30	12	STAT1	stat1	XX
cord-312955-gs65c3fy	30	13	and	and	CC
cord-312955-gs65c3fy	31	1	STAT3	STAT3	NNP
cord-312955-gs65c3fy	31	2	/	/	SYM
cord-312955-gs65c3fy	31	3	STAT3	STAT3	NNP
cord-312955-gs65c3fy	31	4	homodimerization	homodimerization	NN
cord-312955-gs65c3fy	31	5	,	,	,
cord-312955-gs65c3fy	31	6	the	the	DT
cord-312955-gs65c3fy	31	7	formation	formation	NN
cord-312955-gs65c3fy	31	8	of	of	IN
cord-312955-gs65c3fy	31	9	a	a	DT
cord-312955-gs65c3fy	31	10	STAT2	STAT2	NNS
cord-312955-gs65c3fy	31	11	/	/	SYM
cord-312955-gs65c3fy	31	12	IRF9	IRF9	NNP
cord-312955-gs65c3fy	31	13	binary	binary	JJ
cord-312955-gs65c3fy	31	14	complex	complex	NN
cord-312955-gs65c3fy	31	15	and	and	CC
cord-312955-gs65c3fy	31	16	more	more	JJR
cord-312955-gs65c3fy	31	17	(	(	-LRB-
cord-312955-gs65c3fy	31	18	6	6	CD
cord-312955-gs65c3fy	31	19	,	,	,
cord-312955-gs65c3fy	31	20	(	(	-LRB-
cord-312955-gs65c3fy	31	21	10	10	CD
cord-312955-gs65c3fy	31	22	)	)	-RRB-
cord-312955-gs65c3fy	31	23	(	(	-LRB-
cord-312955-gs65c3fy	31	24	11	11	CD
cord-312955-gs65c3fy	31	25	)	)	-RRB-
cord-312955-gs65c3fy	31	26	(	(	-LRB-
cord-312955-gs65c3fy	31	27	12	12	CD
cord-312955-gs65c3fy	31	28	)	)	-RRB-
cord-312955-gs65c3fy	32	1	(	(	-LRB-
cord-312955-gs65c3fy	32	2	Figure	figure	NN
cord-312955-gs65c3fy	32	3	2	2	CD
cord-312955-gs65c3fy	32	4	)	)	-RRB-
cord-312955-gs65c3fy	32	5	.	.	.
cord-312955-gs65c3fy	33	1	This	this	DT
cord-312955-gs65c3fy	33	2	leads	lead	VBZ
cord-312955-gs65c3fy	33	3	to	to	IN
cord-312955-gs65c3fy	33	4	the	the	DT
cord-312955-gs65c3fy	33	5	transcription	transcription	NN
cord-312955-gs65c3fy	33	6	activation	activation	NN
cord-312955-gs65c3fy	33	7	or	or	CC
cord-312955-gs65c3fy	33	8	suppression	suppression	NN
cord-312955-gs65c3fy	33	9	of	of	IN
cord-312955-gs65c3fy	33	10	over	over	IN
cord-312955-gs65c3fy	33	11	1,000	1,000	CD
cord-312955-gs65c3fy	33	12	genes	gene	NNS
cord-312955-gs65c3fy	33	13	,	,	,
cord-312955-gs65c3fy	33	14	which	which	WDT
cord-312955-gs65c3fy	33	15	drive	drive	VBP
cord-312955-gs65c3fy	33	16	a	a	DT
cord-312955-gs65c3fy	33	17	wide	wide	JJ
cord-312955-gs65c3fy	33	18	range	range	NN
cord-312955-gs65c3fy	33	19	of	of	IN
cord-312955-gs65c3fy	33	20	innate	innate	JJ
cord-312955-gs65c3fy	33	21	and	and	CC
cord-312955-gs65c3fy	33	22	adaptive	adaptive	JJ
cord-312955-gs65c3fy	33	23	immune	immune	JJ
cord-312955-gs65c3fy	33	24	functions	function	NNS
cord-312955-gs65c3fy	33	25	.	.	.
cord-312955-gs65c3fy	34	1	These	these	DT
cord-312955-gs65c3fy	34	2	,	,	,
cord-312955-gs65c3fy	34	3	in	in	IN
cord-312955-gs65c3fy	34	4	turn	turn	NN
cord-312955-gs65c3fy	34	5	respond	respond	VBP
cord-312955-gs65c3fy	34	6	against	against	IN
cord-312955-gs65c3fy	34	7	various	various	JJ
cord-312955-gs65c3fy	34	8	pathogens	pathogen	NNS
cord-312955-gs65c3fy	34	9	,	,	,
cord-312955-gs65c3fy	34	10	act	act	VB
cord-312955-gs65c3fy	34	11	as	as	IN
cord-312955-gs65c3fy	34	12	important	important	JJ
cord-312955-gs65c3fy	34	13	regulators	regulator	NNS
cord-312955-gs65c3fy	34	14	in	in	IN
cord-312955-gs65c3fy	34	15	tumor	tumor	NN
cord-312955-gs65c3fy	34	16	immunity	immunity	NN
cord-312955-gs65c3fy	34	17	and	and	CC
cord-312955-gs65c3fy	34	18	have	have	VB
cord-312955-gs65c3fy	34	19	a	a	DT
cord-312955-gs65c3fy	34	20	role	role	NN
cord-312955-gs65c3fy	34	21	in	in	IN
cord-312955-gs65c3fy	34	22	pathophysiology	pathophysiology	NN
cord-312955-gs65c3fy	34	23	and	and	CC
cord-312955-gs65c3fy	34	24	autoimmune	autoimmune	JJ
cord-312955-gs65c3fy	34	25	diseases	disease	NNS
cord-312955-gs65c3fy	34	26	(	(	-LRB-
cord-312955-gs65c3fy	34	27	10	10	CD
cord-312955-gs65c3fy	34	28	,	,	,
cord-312955-gs65c3fy	34	29	(	(	-LRB-
cord-312955-gs65c3fy	34	30	13	13	CD
cord-312955-gs65c3fy	34	31	)	)	-RRB-
cord-312955-gs65c3fy	35	1	(	(	-LRB-
cord-312955-gs65c3fy	35	2	14	14	CD
cord-312955-gs65c3fy	35	3	)	)	-RRB-
cord-312955-gs65c3fy	36	1	(	(	-LRB-
cord-312955-gs65c3fy	36	2	15	15	CD
cord-312955-gs65c3fy	36	3	)	)	-RRB-
cord-312955-gs65c3fy	36	4	(	(	-LRB-
cord-312955-gs65c3fy	36	5	16	16	CD
cord-312955-gs65c3fy	36	6	)	)	-RRB-
cord-312955-gs65c3fy	36	7	(	(	-LRB-
cord-312955-gs65c3fy	36	8	17	17	CD
cord-312955-gs65c3fy	36	9	)	)	-RRB-
cord-312955-gs65c3fy	36	10	(	(	-LRB-
cord-312955-gs65c3fy	36	11	18	18	CD
cord-312955-gs65c3fy	36	12	)	)	-RRB-
cord-312955-gs65c3fy	36	13	.	.	.
cord-312955-gs65c3fy	37	1	STAT2	STAT2	NNS
cord-312955-gs65c3fy	37	2	knockout	knockout	NN
cord-312955-gs65c3fy	37	3	cells	cell	NNS
cord-312955-gs65c3fy	37	4	still	still	RB
cord-312955-gs65c3fy	37	5	activate	activate	VBP
cord-312955-gs65c3fy	37	6	a	a	DT
cord-312955-gs65c3fy	37	7	STAT1	stat1	NN
cord-312955-gs65c3fy	37	8	/	/	SYM
cord-312955-gs65c3fy	37	9	STAT1	stat1	NN
cord-312955-gs65c3fy	37	10	response	response	NN
cord-312955-gs65c3fy	37	11	mediated	mediate	VBN
cord-312955-gs65c3fy	37	12	by	by	IN
cord-312955-gs65c3fy	37	13	IRF1	IRF1	NNP
cord-312955-gs65c3fy	37	14	,	,	,
cord-312955-gs65c3fy	37	15	while	while	IN
cord-312955-gs65c3fy	37	16	STAT1	stat1	NN
cord-312955-gs65c3fy	37	17	knockout	knockout	NN
cord-312955-gs65c3fy	37	18	cells	cell	NNS
cord-312955-gs65c3fy	37	19	activate	activate	VBP
cord-312955-gs65c3fy	37	20	a	a	DT
cord-312955-gs65c3fy	37	21	STAT2	STAT2	NNS
cord-312955-gs65c3fy	37	22	/	/	SYM
cord-312955-gs65c3fy	37	23	IRF9-induced	irf9-induced	JJ
cord-312955-gs65c3fy	37	24	response	response	NN
cord-312955-gs65c3fy	37	25	(	(	-LRB-
cord-312955-gs65c3fy	37	26	10	10	CD
cord-312955-gs65c3fy	37	27	)	)	-RRB-
cord-312955-gs65c3fy	37	28	.	.	.
cord-312955-gs65c3fy	38	1	Surprisingly	surprisingly	RB
cord-312955-gs65c3fy	38	2	,	,	,
cord-312955-gs65c3fy	38	3	no	no	DT
cord-312955-gs65c3fy	38	4	change	change	NN
cord-312955-gs65c3fy	38	5	in	in	IN
cord-312955-gs65c3fy	38	6	the	the	DT
cord-312955-gs65c3fy	38	7	gene	gene	NN
cord-312955-gs65c3fy	38	8	induction	induction	NN
cord-312955-gs65c3fy	38	9	relative	relative	NN
cord-312955-gs65c3fy	38	10	to	to	IN
cord-312955-gs65c3fy	38	11	wildtype	wildtype	NN
cord-312955-gs65c3fy	38	12	cells	cell	NNS
cord-312955-gs65c3fy	38	13	was	be	VBD
cord-312955-gs65c3fy	38	14	observed	observe	VBN
cord-312955-gs65c3fy	38	15	in	in	IN
cord-312955-gs65c3fy	38	16	STAT3	stat3	CD
cord-312955-gs65c3fy	38	17	knockout	knockout	NN
cord-312955-gs65c3fy	38	18	HeLa	HeLa	NNP
cord-312955-gs65c3fy	38	19	cells	cell	NNS
cord-312955-gs65c3fy	38	20	,	,	,
cord-312955-gs65c3fy	38	21	despite	despite	IN
cord-312955-gs65c3fy	38	22	the	the	DT
cord-312955-gs65c3fy	38	23	strong	strong	JJ
cord-312955-gs65c3fy	38	24	IFN	IFN	NNP
cord-312955-gs65c3fy	38	25	-	-	HYPH
cord-312955-gs65c3fy	38	26	I	I	NNP
cord-312955-gs65c3fy	38	27	-	-	HYPH
cord-312955-gs65c3fy	38	28	induced	induce	VBN
cord-312955-gs65c3fy	38	29	phosphorylation	phosphorylation	NN
cord-312955-gs65c3fy	38	30	of	of	IN
cord-312955-gs65c3fy	38	31	STAT3	STAT3	NNP
cord-312955-gs65c3fy	38	32	.	.	.
cord-312955-gs65c3fy	39	1	However	however	RB
cord-312955-gs65c3fy	39	2	,	,	,
cord-312955-gs65c3fy	39	3	as	as	IN
cord-312955-gs65c3fy	39	4	IFN	IFN	NNP
cord-312955-gs65c3fy	39	5	-	-	HYPH
cord-312955-gs65c3fy	39	6	I	-PRON-	PRP
cord-312955-gs65c3fy	39	7	responses	response	NNS
cord-312955-gs65c3fy	39	8	are	be	VBP
cord-312955-gs65c3fy	39	9	cell	cell	NN
cord-312955-gs65c3fy	39	10	-	-	HYPH
cord-312955-gs65c3fy	39	11	type	type	NN
cord-312955-gs65c3fy	39	12	specific	specific	NN
cord-312955-gs65c3fy	39	13	,	,	,
cord-312955-gs65c3fy	39	14	a	a	DT
cord-312955-gs65c3fy	39	15	STAT3	stat3	CD
cord-312955-gs65c3fy	39	16	/	/	SYM
cord-312955-gs65c3fy	39	17	STAT3induced	stat3induced	JJ
cord-312955-gs65c3fy	39	18	response	response	NN
cord-312955-gs65c3fy	39	19	may	may	MD
cord-312955-gs65c3fy	39	20	still	still	RB
cord-312955-gs65c3fy	39	21	be	be	VB
cord-312955-gs65c3fy	39	22	found	find	VBN
cord-312955-gs65c3fy	39	23	in	in	IN
cord-312955-gs65c3fy	39	24	other	other	JJ
cord-312955-gs65c3fy	39	25	cells	cell	NNS
cord-312955-gs65c3fy	39	26	than	than	IN
cord-312955-gs65c3fy	39	27	HeLa	HeLa	NNP
cord-312955-gs65c3fy	39	28	.	.	.
cord-312955-gs65c3fy	40	1	Due	due	IN
cord-312955-gs65c3fy	40	2	to	to	IN
cord-312955-gs65c3fy	40	3	this	this	DT
cord-312955-gs65c3fy	40	4	wide	wide	JJ
cord-312955-gs65c3fy	40	5	range	range	NN
cord-312955-gs65c3fy	40	6	of	of	IN
cord-312955-gs65c3fy	40	7	physiological	physiological	JJ
cord-312955-gs65c3fy	40	8	responses	response	NNS
cord-312955-gs65c3fy	40	9	,	,	,
cord-312955-gs65c3fy	40	10	IFN	IFN	NNP
cord-312955-gs65c3fy	40	11	-	-	HYPH
cord-312955-gs65c3fy	40	12	I	-PRON-	PRP
cord-312955-gs65c3fy	40	13	has	have	VBZ
cord-312955-gs65c3fy	40	14	provided	provide	VBN
cord-312955-gs65c3fy	40	15	therapeutic	therapeutic	JJ
cord-312955-gs65c3fy	40	16	benefits	benefit	NNS
cord-312955-gs65c3fy	40	17	for	for	IN
cord-312955-gs65c3fy	40	18	multiple	multiple	JJ
cord-312955-gs65c3fy	40	19	diseases	disease	NNS
cord-312955-gs65c3fy	40	20	,	,	,
cord-312955-gs65c3fy	40	21	including	include	VBG
cord-312955-gs65c3fy	40	22	multiple	multiple	JJ
cord-312955-gs65c3fy	40	23	sclerosis	sclerosis	NN
cord-312955-gs65c3fy	40	24	,	,	,
cord-312955-gs65c3fy	40	25	some	some	DT
cord-312955-gs65c3fy	40	26	cancers	cancer	NNS
cord-312955-gs65c3fy	40	27	and	and	CC
cord-312955-gs65c3fy	40	28	viral	viral	JJ
cord-312955-gs65c3fy	40	29	diseases	disease	NNS
cord-312955-gs65c3fy	40	30	(	(	-LRB-
cord-312955-gs65c3fy	40	31	hepatitis	hepatitis	NNP
cord-312955-gs65c3fy	40	32	B	B	NNP
cord-312955-gs65c3fy	40	33	and	and	CC
cord-312955-gs65c3fy	40	34	C	C	NNP
cord-312955-gs65c3fy	40	35	)	)	-RRB-
cord-312955-gs65c3fy	40	36	(	(	-LRB-
cord-312955-gs65c3fy	40	37	19	19	CD
cord-312955-gs65c3fy	40	38	)	)	-RRB-
cord-312955-gs65c3fy	40	39	(	(	-LRB-
cord-312955-gs65c3fy	40	40	20	20	CD
cord-312955-gs65c3fy	40	41	)	)	-RRB-
cord-312955-gs65c3fy	40	42	(	(	-LRB-
cord-312955-gs65c3fy	40	43	21	21	CD
cord-312955-gs65c3fy	40	44	)	)	-RRB-
cord-312955-gs65c3fy	40	45	.	.	.
cord-312955-gs65c3fy	41	1	Due	due	IN
cord-312955-gs65c3fy	41	2	to	to	IN
cord-312955-gs65c3fy	41	3	the	the	DT
cord-312955-gs65c3fy	41	4	efficient	efficient	JJ
cord-312955-gs65c3fy	41	5	activation	activation	NN
cord-312955-gs65c3fy	41	6	of	of	IN
cord-312955-gs65c3fy	41	7	antiviral	antiviral	JJ
cord-312955-gs65c3fy	41	8	activities	activity	NNS
cord-312955-gs65c3fy	41	9	by	by	IN
cord-312955-gs65c3fy	41	10	IFN	IFN	NNP
cord-312955-gs65c3fy	41	11	-	-	HYPH
cord-312955-gs65c3fy	41	12	Is	be	VBZ
cord-312955-gs65c3fy	41	13	,	,	,
cord-312955-gs65c3fy	41	14	most	most	JJS
cord-312955-gs65c3fy	41	15	viruses	virus	NNS
cord-312955-gs65c3fy	41	16	have	have	VBP
cord-312955-gs65c3fy	41	17	contemplated	contemplate	VBN
cord-312955-gs65c3fy	41	18	mechanisms	mechanism	NNS
cord-312955-gs65c3fy	41	19	to	to	TO
cord-312955-gs65c3fy	41	20	avoid	avoid	VB
cord-312955-gs65c3fy	41	21	its	-PRON-	PRP$
cord-312955-gs65c3fy	41	22	actions	action	NNS
cord-312955-gs65c3fy	41	23	(	(	-LRB-
cord-312955-gs65c3fy	41	24	22	22	CD
cord-312955-gs65c3fy	41	25	)	)	-RRB-
cord-312955-gs65c3fy	41	26	(	(	-LRB-
cord-312955-gs65c3fy	41	27	23	23	CD
cord-312955-gs65c3fy	41	28	)	)	-RRB-
cord-312955-gs65c3fy	41	29	(	(	-LRB-
cord-312955-gs65c3fy	41	30	24	24	CD
cord-312955-gs65c3fy	41	31	)	)	-RRB-
cord-312955-gs65c3fy	41	32	.	.	.
cord-312955-gs65c3fy	42	1	For	for	IN
cord-312955-gs65c3fy	42	2	example	example	NN
cord-312955-gs65c3fy	42	3	,	,	,
cord-312955-gs65c3fy	42	4	the	the	DT
cord-312955-gs65c3fy	42	5	Ebola	Ebola	NNP
cord-312955-gs65c3fy	42	6	virus	virus	NN
cord-312955-gs65c3fy	42	7	,	,	,
cord-312955-gs65c3fy	42	8	which	which	WDT
cord-312955-gs65c3fy	42	9	outbreak	outbreak	NN
cord-312955-gs65c3fy	42	10	in	in	IN
cord-312955-gs65c3fy	42	11	central	central	JJ
cord-312955-gs65c3fy	42	12	Africa	Africa	NNP
cord-312955-gs65c3fy	42	13	killed	kill	VBD
cord-312955-gs65c3fy	42	14	tens	ten	NNS
cord-312955-gs65c3fy	42	15	of	of	IN
cord-312955-gs65c3fy	42	16	thousands	thousand	NNS
cord-312955-gs65c3fy	42	17	of	of	IN
cord-312955-gs65c3fy	42	18	people	people	NNS
cord-312955-gs65c3fy	42	19	(	(	-LRB-
cord-312955-gs65c3fy	42	20	25	25	CD
cord-312955-gs65c3fy	42	21	,	,	,
cord-312955-gs65c3fy	42	22	26	26	CD
cord-312955-gs65c3fy	42	23	)	)	-RRB-
cord-312955-gs65c3fy	42	24	,	,	,
cord-312955-gs65c3fy	42	25	avoids	avoid	VBZ
cord-312955-gs65c3fy	42	26	IFN	IFN	NNP
cord-312955-gs65c3fy	42	27	-	-	HYPH
cord-312955-gs65c3fy	42	28	I	I	NNP
cord-312955-gs65c3fy	42	29	activity	activity	NN
cord-312955-gs65c3fy	42	30	by	by	IN
cord-312955-gs65c3fy	42	31	producing	produce	VBG
cord-312955-gs65c3fy	42	32	the	the	DT
cord-312955-gs65c3fy	42	33	VP24	VP24	NNP
cord-312955-gs65c3fy	42	34	protein	protein	NN
cord-312955-gs65c3fy	42	35	that	that	WDT
cord-312955-gs65c3fy	42	36	binds	bind	VBZ
cord-312955-gs65c3fy	42	37	the	the	DT
cord-312955-gs65c3fy	42	38	karyopherin	karyopherin	NNP
cord-312955-gs65c3fy	42	39	alpha	alpha	NNP
cord-312955-gs65c3fy	42	40	nuclear	nuclear	JJ
cord-312955-gs65c3fy	42	41	transporter	transporter	NN
cord-312955-gs65c3fy	42	42	.	.	.
cord-312955-gs65c3fy	43	1	Thereby	thereby	RB
cord-312955-gs65c3fy	43	2	,	,	,
cord-312955-gs65c3fy	43	3	it	-PRON-	PRP
cord-312955-gs65c3fy	43	4	inhibits	inhibit	VBZ
cord-312955-gs65c3fy	43	5	the	the	DT
cord-312955-gs65c3fy	43	6	nuclear	nuclear	JJ
cord-312955-gs65c3fy	43	7	transport	transport	NN
cord-312955-gs65c3fy	43	8	of	of	IN
cord-312955-gs65c3fy	43	9	phosphorylated	phosphorylated	JJ
cord-312955-gs65c3fy	43	10	STAT1	stat1	NN
cord-312955-gs65c3fy	43	11	,	,	,
cord-312955-gs65c3fy	43	12	rendering	render	VBG
cord-312955-gs65c3fy	43	13	cells	cell	NNS
cord-312955-gs65c3fy	43	14	refractory	refractory	JJ
cord-312955-gs65c3fy	43	15	to	to	IN
cord-312955-gs65c3fy	43	16	IFN	IFN	NNP
cord-312955-gs65c3fy	43	17	-	-	HYPH
cord-312955-gs65c3fy	43	18	Is	be	VBZ
cord-312955-gs65c3fy	43	19	.	.	.
cord-312955-gs65c3fy	44	1	Another	another	DT
cord-312955-gs65c3fy	44	2	example	example	NN
cord-312955-gs65c3fy	44	3	of	of	IN
cord-312955-gs65c3fy	44	4	viral	viral	JJ
cord-312955-gs65c3fy	44	5	mechanisms	mechanism	NNS
cord-312955-gs65c3fy	44	6	that	that	WDT
cord-312955-gs65c3fy	44	7	evolved	evolve	VBD
cord-312955-gs65c3fy	44	8	to	to	TO
cord-312955-gs65c3fy	44	9	eliminate	eliminate	VB
cord-312955-gs65c3fy	44	10	IFN	IFN	NNP
cord-312955-gs65c3fy	44	11	-	-	HYPH
cord-312955-gs65c3fy	44	12	I	-PRON-	PRP
cord-312955-gs65c3fy	44	13	functions	function	VBZ
cord-312955-gs65c3fy	44	14	in	in	IN
cord-312955-gs65c3fy	44	15	inducing	induce	VBG
cord-312955-gs65c3fy	44	16	innate	innate	JJ
cord-312955-gs65c3fy	44	17	immunity	immunity	NN
cord-312955-gs65c3fy	44	18	is	be	VBZ
cord-312955-gs65c3fy	44	19	given	give	VBN
cord-312955-gs65c3fy	44	20	by	by	IN
cord-312955-gs65c3fy	44	21	the	the	DT
cord-312955-gs65c3fy	44	22	SARS	SARS	NNP
cord-312955-gs65c3fy	44	23	corona	corona	NNP
cord-312955-gs65c3fy	44	24	virus	virus	NN
cord-312955-gs65c3fy	44	25	,	,	,
cord-312955-gs65c3fy	44	26	where	where	WRB
cord-312955-gs65c3fy	44	27	both	both	CC
cord-312955-gs65c3fy	44	28	the	the	DT
cord-312955-gs65c3fy	44	29	production	production	NN
cord-312955-gs65c3fy	44	30	of	of	IN
cord-312955-gs65c3fy	44	31	IFNb	IFNb	NNS
cord-312955-gs65c3fy	44	32	and	and	CC
cord-312955-gs65c3fy	44	33	the	the	DT
cord-312955-gs65c3fy	44	34	IFN	IFN	NNP
cord-312955-gs65c3fy	44	35	-	-	HYPH
cord-312955-gs65c3fy	44	36	I	I	NNP
cord-312955-gs65c3fy	44	37	induced	induce	VBD
cord-312955-gs65c3fy	44	38	signaling	signal	VBG
cord-312955-gs65c3fy	44	39	are	be	VBP
cord-312955-gs65c3fy	44	40	attenuated	attenuate	VBN
cord-312955-gs65c3fy	44	41	.	.	.
cord-312955-gs65c3fy	45	1	Recently	recently	RB
cord-312955-gs65c3fy	45	2	,	,	,
cord-312955-gs65c3fy	45	3	a	a	DT
cord-312955-gs65c3fy	45	4	more	more	RBR
cord-312955-gs65c3fy	45	5	infective	infective	JJ
cord-312955-gs65c3fy	45	6	version	version	NN
cord-312955-gs65c3fy	45	7	of	of	IN
cord-312955-gs65c3fy	45	8	SARS	SARS	NNP
cord-312955-gs65c3fy	45	9	has	have	VBZ
cord-312955-gs65c3fy	45	10	emerged	emerge	VBN
cord-312955-gs65c3fy	45	11	,	,	,
cord-312955-gs65c3fy	45	12	SARS	SARS	NNP
cord-312955-gs65c3fy	45	13	-	-	HYPH
cord-312955-gs65c3fy	45	14	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	45	15	(	(	-LRB-
cord-312955-gs65c3fy	45	16	which	which	WDT
cord-312955-gs65c3fy	45	17	causes	cause	VBZ
cord-312955-gs65c3fy	45	18	the	the	DT
cord-312955-gs65c3fy	45	19	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	45	20	disease	disease	NN
cord-312955-gs65c3fy	45	21	)	)	-RRB-
cord-312955-gs65c3fy	45	22	.	.	.
cord-312955-gs65c3fy	46	1	COVID-19	covid-19	JJ
cord-312955-gs65c3fy	46	2	cases	case	NNS
cord-312955-gs65c3fy	46	3	have	have	VBP
cord-312955-gs65c3fy	46	4	been	be	VBN
cord-312955-gs65c3fy	46	5	first	first	RB
cord-312955-gs65c3fy	46	6	reported	report	VBN
cord-312955-gs65c3fy	46	7	by	by	IN
cord-312955-gs65c3fy	46	8	the	the	DT
cord-312955-gs65c3fy	46	9	end	end	NN
cord-312955-gs65c3fy	46	10	of	of	IN
cord-312955-gs65c3fy	46	11	2019	2019	CD
cord-312955-gs65c3fy	46	12	in	in	IN
cord-312955-gs65c3fy	46	13	China	China	NNP
cord-312955-gs65c3fy	46	14	,	,	,
cord-312955-gs65c3fy	46	15	and	and	CC
cord-312955-gs65c3fy	46	16	rapidly	rapidly	RB
cord-312955-gs65c3fy	46	17	became	become	VBD
cord-312955-gs65c3fy	46	18	a	a	DT
cord-312955-gs65c3fy	46	19	world	world	NN
cord-312955-gs65c3fy	46	20	-	-	HYPH
cord-312955-gs65c3fy	46	21	wide	wide	JJ
cord-312955-gs65c3fy	46	22	epidemic	epidemic	NN
cord-312955-gs65c3fy	46	23	with	with	IN
cord-312955-gs65c3fy	46	24	unprecedented	unprecedented	JJ
cord-312955-gs65c3fy	46	25	consequences	consequence	NNS
cord-312955-gs65c3fy	46	26	(	(	-LRB-
cord-312955-gs65c3fy	46	27	27	27	CD
cord-312955-gs65c3fy	46	28	,	,	,
cord-312955-gs65c3fy	46	29	28	28	CD
cord-312955-gs65c3fy	46	30	)	)	-RRB-
cord-312955-gs65c3fy	46	31	.	.	.
cord-312955-gs65c3fy	47	1	SARS	SARS	NNP
cord-312955-gs65c3fy	47	2	-	-	HYPH
cord-312955-gs65c3fy	47	3	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	47	4	seems	seem	VBZ
cord-312955-gs65c3fy	47	5	to	to	TO
cord-312955-gs65c3fy	47	6	have	have	VB
cord-312955-gs65c3fy	47	7	originated	originate	VBN
cord-312955-gs65c3fy	47	8	from	from	IN
cord-312955-gs65c3fy	47	9	horseshoe	horseshoe	NN
cord-312955-gs65c3fy	47	10	bats	bat	NNS
cord-312955-gs65c3fy	47	11	.	.	.
cord-312955-gs65c3fy	48	1	Similar	similar	JJ
cord-312955-gs65c3fy	48	2	virus	virus	NN
cord-312955-gs65c3fy	48	3	strains	strain	NNS
cord-312955-gs65c3fy	48	4	that	that	WDT
cord-312955-gs65c3fy	48	5	circulate	circulate	VBP
cord-312955-gs65c3fy	48	6	in	in	IN
cord-312955-gs65c3fy	48	7	bats	bat	NNS
cord-312955-gs65c3fy	48	8	in	in	IN
cord-312955-gs65c3fy	48	9	Hubei	Hubei	NNP
cord-312955-gs65c3fy	48	10	province	province	NN
cord-312955-gs65c3fy	48	11	in	in	IN
cord-312955-gs65c3fy	48	12	China	China	NNP
cord-312955-gs65c3fy	49	1	may	may	MD
cord-312955-gs65c3fy	49	2	in	in	IN
cord-312955-gs65c3fy	49	3	the	the	DT
cord-312955-gs65c3fy	49	4	future	future	NN
cord-312955-gs65c3fy	49	5	cause	cause	VB
cord-312955-gs65c3fy	49	6	further	further	JJ
cord-312955-gs65c3fy	49	7	new	new	JJ
cord-312955-gs65c3fy	49	8	zoonotic	zoonotic	JJ
cord-312955-gs65c3fy	49	9	outbreaks	outbreak	NNS
cord-312955-gs65c3fy	49	10	(	(	-LRB-
cord-312955-gs65c3fy	49	11	29	29	CD
cord-312955-gs65c3fy	49	12	)	)	-RRB-
cord-312955-gs65c3fy	49	13	.	.	.
cord-312955-gs65c3fy	50	1	SARS	SARS	NNP
cord-312955-gs65c3fy	50	2	-	-	HYPH
cord-312955-gs65c3fy	50	3	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	50	4	has	have	VBZ
cord-312955-gs65c3fy	50	5	83	83	CD
cord-312955-gs65c3fy	50	6	%	%	NN
cord-312955-gs65c3fy	50	7	homology	homology	NN
cord-312955-gs65c3fy	50	8	to	to	IN
cord-312955-gs65c3fy	50	9	the	the	DT
cord-312955-gs65c3fy	50	10	SARS	SARS	NNP
cord-312955-gs65c3fy	50	11	-	-	HYPH
cord-312955-gs65c3fy	50	12	CoV	CoV	NNP
cord-312955-gs65c3fy	50	13	virus	virus	NN
cord-312955-gs65c3fy	50	14	that	that	WDT
cord-312955-gs65c3fy	50	15	also	also	RB
cord-312955-gs65c3fy	50	16	spread	spread	VBD
cord-312955-gs65c3fy	50	17	from	from	IN
cord-312955-gs65c3fy	50	18	China	China	NNP
cord-312955-gs65c3fy	50	19	in	in	IN
cord-312955-gs65c3fy	50	20	2002	2002	CD
cord-312955-gs65c3fy	50	21	(	(	-LRB-
cord-312955-gs65c3fy	50	22	30	30	CD
cord-312955-gs65c3fy	50	23	)	)	-RRB-
cord-312955-gs65c3fy	50	24	.	.	.
cord-312955-gs65c3fy	51	1	SARS	SARS	NNP
cord-312955-gs65c3fy	51	2	-	-	HYPH
cord-312955-gs65c3fy	51	3	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	51	4	proved	prove	VBD
cord-312955-gs65c3fy	51	5	to	to	TO
cord-312955-gs65c3fy	51	6	be	be	VB
cord-312955-gs65c3fy	51	7	much	much	RB
cord-312955-gs65c3fy	51	8	more	more	RBR
cord-312955-gs65c3fy	51	9	infectious	infectious	JJ
cord-312955-gs65c3fy	51	10	compared	compare	VBN
cord-312955-gs65c3fy	51	11	to	to	IN
cord-312955-gs65c3fy	51	12	the	the	DT
cord-312955-gs65c3fy	51	13	original	original	JJ
cord-312955-gs65c3fy	51	14	SARS	SARS	NNP
cord-312955-gs65c3fy	51	15	virus	virus	NN
cord-312955-gs65c3fy	51	16	,	,	,
cord-312955-gs65c3fy	51	17	resulting	result	VBG
cord-312955-gs65c3fy	51	18	in	in	IN
cord-312955-gs65c3fy	51	19	a	a	DT
cord-312955-gs65c3fy	51	20	global	global	JJ
cord-312955-gs65c3fy	51	21	epidemic	epidemic	NN
cord-312955-gs65c3fy	51	22	.	.	.
cord-312955-gs65c3fy	52	1	As	as	IN
cord-312955-gs65c3fy	52	2	IFN	IFN	NNP
cord-312955-gs65c3fy	52	3	-	-	HYPH
cord-312955-gs65c3fy	52	4	I	-PRON-	PRP
cord-312955-gs65c3fy	52	5	drives	drive	VBZ
cord-312955-gs65c3fy	52	6	strong	strong	JJ
cord-312955-gs65c3fy	52	7	antiviral	antiviral	JJ
cord-312955-gs65c3fy	52	8	activities	activity	NNS
cord-312955-gs65c3fy	52	9	,	,	,
cord-312955-gs65c3fy	52	10	the	the	DT
cord-312955-gs65c3fy	52	11	mechanisms	mechanism	NNS
cord-312955-gs65c3fy	52	12	SARS	SARS	NNP
cord-312955-gs65c3fy	52	13	-	-	HYPH
cord-312955-gs65c3fy	52	14	CoV	CoV	NNP
cord-312955-gs65c3fy	52	15	and	and	CC
cord-312955-gs65c3fy	52	16	SARS	SARS	NNP
cord-312955-gs65c3fy	52	17	-	-	HYPH
cord-312955-gs65c3fy	52	18	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	52	19	combat	combat	NN
cord-312955-gs65c3fy	52	20	IFN	IFN	NNP
cord-312955-gs65c3fy	52	21	-	-	HYPH
cord-312955-gs65c3fy	52	22	I	I	NNP
cord-312955-gs65c3fy	53	1	activities	activity	NNS
cord-312955-gs65c3fy	53	2	has	have	VBZ
cord-312955-gs65c3fy	53	3	been	be	VBN
cord-312955-gs65c3fy	53	4	a	a	DT
cord-312955-gs65c3fy	53	5	matter	matter	NN
cord-312955-gs65c3fy	53	6	of	of	IN
cord-312955-gs65c3fy	53	7	intense	intense	JJ
cord-312955-gs65c3fy	53	8	research	research	NN
cord-312955-gs65c3fy	53	9	,	,	,
cord-312955-gs65c3fy	53	10	with	with	IN
cord-312955-gs65c3fy	53	11	at	at	RB
cord-312955-gs65c3fy	53	12	least	least	JJS
cord-312955-gs65c3fy	53	13	6	6	CD
cord-312955-gs65c3fy	53	14	proteins	protein	NNS
cord-312955-gs65c3fy	53	15	being	be	VBG
cord-312955-gs65c3fy	53	16	identified	identify	VBN
cord-312955-gs65c3fy	53	17	to	to	TO
cord-312955-gs65c3fy	53	18	counteract	counteract	VB
cord-312955-gs65c3fy	53	19	IFN	IFN	NNP
cord-312955-gs65c3fy	53	20	-	-	HYPH
cord-312955-gs65c3fy	53	21	I	-PRON-	PRP
cord-312955-gs65c3fy	53	22	functions	function	VBZ
cord-312955-gs65c3fy	53	23	in	in	IN
cord-312955-gs65c3fy	53	24	the	the	DT
cord-312955-gs65c3fy	53	25	SARS	SARS	NNP
cord-312955-gs65c3fy	53	26	-	-	HYPH
cord-312955-gs65c3fy	53	27	CoV	CoV	NNP
cord-312955-gs65c3fy	53	28	virus	virus	NN
cord-312955-gs65c3fy	53	29	(	(	-LRB-
cord-312955-gs65c3fy	53	30	31	31	CD
cord-312955-gs65c3fy	53	31	)	)	-RRB-
cord-312955-gs65c3fy	53	32	.	.	.
cord-312955-gs65c3fy	54	1	In	in	IN
cord-312955-gs65c3fy	54	2	addition	addition	NN
cord-312955-gs65c3fy	54	3	,	,	,
cord-312955-gs65c3fy	54	4	IFN	IFN	NNP
cord-312955-gs65c3fy	54	5	-	-	:
cord-312955-gs65c3fy	54	6	Is	be	VBZ
cord-312955-gs65c3fy	54	7	were	be	VBD
cord-312955-gs65c3fy	54	8	implicated	implicate	VBN
cord-312955-gs65c3fy	54	9	in	in	IN
cord-312955-gs65c3fy	54	10	contributing	contribute	VBG
cord-312955-gs65c3fy	54	11	to	to	IN
cord-312955-gs65c3fy	54	12	the	the	DT
cord-312955-gs65c3fy	54	13	severity	severity	NN
cord-312955-gs65c3fy	54	14	of	of	IN
cord-312955-gs65c3fy	54	15	the	the	DT
cord-312955-gs65c3fy	54	16	cytokine	cytokine	NN
cord-312955-gs65c3fy	54	17	storm	storm	NN
cord-312955-gs65c3fy	54	18	,	,	,
cord-312955-gs65c3fy	54	19	which	which	WDT
cord-312955-gs65c3fy	54	20	is	be	VBZ
cord-312955-gs65c3fy	54	21	a	a	DT
cord-312955-gs65c3fy	54	22	major	major	JJ
cord-312955-gs65c3fy	54	23	complication	complication	NN
cord-312955-gs65c3fy	54	24	of	of	IN
cord-312955-gs65c3fy	54	25	SARS	SARS	NNP
cord-312955-gs65c3fy	54	26	-	-	HYPH
cord-312955-gs65c3fy	54	27	CoV	CoV	NNP
cord-312955-gs65c3fy	54	28	and	and	CC
cord-312955-gs65c3fy	54	29	SARS	SARS	NNP
cord-312955-gs65c3fy	54	30	-	-	HYPH
cord-312955-gs65c3fy	54	31	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	54	32	and	and	CC
cord-312955-gs65c3fy	54	33	can	can	MD
cord-312955-gs65c3fy	54	34	lead	lead	VB
cord-312955-gs65c3fy	54	35	to	to	IN
cord-312955-gs65c3fy	54	36	respiratory	respiratory	JJ
cord-312955-gs65c3fy	54	37	distress	distress	NN
cord-312955-gs65c3fy	54	38	syndrome	syndrome	NN
cord-312955-gs65c3fy	54	39	(	(	-LRB-
cord-312955-gs65c3fy	54	40	ARDS	ARDS	NNP
cord-312955-gs65c3fy	54	41	)	)	-RRB-
cord-312955-gs65c3fy	54	42	and	and	CC
cord-312955-gs65c3fy	54	43	death	death	NN
cord-312955-gs65c3fy	54	44	(	(	-LRB-
cord-312955-gs65c3fy	54	45	31	31	CD
cord-312955-gs65c3fy	54	46	,	,	,
cord-312955-gs65c3fy	54	47	32	32	CD
cord-312955-gs65c3fy	54	48	)	)	-RRB-
cord-312955-gs65c3fy	54	49	.	.	.
cord-312955-gs65c3fy	55	1	In	in	IN
cord-312955-gs65c3fy	55	2	this	this	DT
cord-312955-gs65c3fy	55	3	review	review	NN
cord-312955-gs65c3fy	55	4	I	-PRON-	PRP
cord-312955-gs65c3fy	55	5	will	will	MD
cord-312955-gs65c3fy	55	6	describe	describe	VB
cord-312955-gs65c3fy	55	7	our	-PRON-	PRP$
cord-312955-gs65c3fy	55	8	current	current	JJ
cord-312955-gs65c3fy	55	9	knowledge	knowledge	NN
cord-312955-gs65c3fy	55	10	on	on	IN
cord-312955-gs65c3fy	55	11	the	the	DT
cord-312955-gs65c3fy	55	12	involvement	involvement	NN
cord-312955-gs65c3fy	55	13	of	of	IN
cord-312955-gs65c3fy	55	14	IFN	IFN	NNP
cord-312955-gs65c3fy	55	15	-	-	,
cord-312955-gs65c3fy	55	16	Is	be	VBZ
cord-312955-gs65c3fy	55	17	in	in	IN
cord-312955-gs65c3fy	55	18	the	the	DT
cord-312955-gs65c3fy	55	19	development	development	NN
cord-312955-gs65c3fy	55	20	of	of	IN
cord-312955-gs65c3fy	55	21	the	the	DT
cord-312955-gs65c3fy	55	22	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	55	23	disease	disease	NN
cord-312955-gs65c3fy	55	24	,	,	,
cord-312955-gs65c3fy	55	25	and	and	CC
cord-312955-gs65c3fy	55	26	how	how	WRB
cord-312955-gs65c3fy	55	27	this	this	DT
cord-312955-gs65c3fy	55	28	relates	relate	VBZ
cord-312955-gs65c3fy	55	29	to	to	IN
cord-312955-gs65c3fy	55	30	the	the	DT
cord-312955-gs65c3fy	55	31	different	different	JJ
cord-312955-gs65c3fy	55	32	activities	activity	NNS
cord-312955-gs65c3fy	55	33	associated	associate	VBN
cord-312955-gs65c3fy	55	34	with	with	IN
cord-312955-gs65c3fy	55	35	type	type	NN
cord-312955-gs65c3fy	55	36	I	-PRON-	PRP
cord-312955-gs65c3fy	55	37	interferons	interferon	NNS
cord-312955-gs65c3fy	55	38	.	.	.
cord-312955-gs65c3fy	56	1	Type	type	NN
cord-312955-gs65c3fy	56	2	I	-PRON-	PRP
cord-312955-gs65c3fy	56	3	interferon	interferon	NN
cord-312955-gs65c3fy	56	4	receptors	receptor	NNS
cord-312955-gs65c3fy	56	5	are	be	VBP
cord-312955-gs65c3fy	56	6	found	find	VBN
cord-312955-gs65c3fy	56	7	on	on	IN
cord-312955-gs65c3fy	56	8	all	all	DT
cord-312955-gs65c3fy	56	9	cell	cell	NN
cord-312955-gs65c3fy	56	10	types	type	NNS
cord-312955-gs65c3fy	56	11	,	,	,
cord-312955-gs65c3fy	56	12	and	and	CC
cord-312955-gs65c3fy	56	13	are	be	VBP
cord-312955-gs65c3fy	56	14	a	a	DT
cord-312955-gs65c3fy	56	15	major	major	JJ
cord-312955-gs65c3fy	56	16	component	component	NN
cord-312955-gs65c3fy	56	17	of	of	IN
cord-312955-gs65c3fy	56	18	the	the	DT
cord-312955-gs65c3fy	56	19	innate	innate	JJ
cord-312955-gs65c3fy	56	20	immune	immune	JJ
cord-312955-gs65c3fy	56	21	system	system	NN
cord-312955-gs65c3fy	56	22	.	.	.
cord-312955-gs65c3fy	57	1	Human	human	JJ
cord-312955-gs65c3fy	57	2	type	type	NN
cord-312955-gs65c3fy	57	3	I	-PRON-	PRP
cord-312955-gs65c3fy	57	4	interferons	interferon	NNS
cord-312955-gs65c3fy	57	5	include	include	VBP
cord-312955-gs65c3fy	57	6	13	13	CD
cord-312955-gs65c3fy	57	7	similar	similar	JJ
cord-312955-gs65c3fy	57	8	IFNas	IFNas	NNP
cord-312955-gs65c3fy	57	9	with	with	IN
cord-312955-gs65c3fy	57	10	80	80	CD
cord-312955-gs65c3fy	57	11	%	%	NN
cord-312955-gs65c3fy	57	12	homology	homology	NN
cord-312955-gs65c3fy	57	13	between	between	IN
cord-312955-gs65c3fy	57	14	them	-PRON-	PRP
cord-312955-gs65c3fy	57	15	and	and	CC
cord-312955-gs65c3fy	57	16	single	single	JJ
cord-312955-gs65c3fy	57	17	IFNw	IFNw	NNS
cord-312955-gs65c3fy	57	18	,	,	,
cord-312955-gs65c3fy	57	19	k	k	NNP
cord-312955-gs65c3fy	57	20	,	,	,
cord-312955-gs65c3fy	57	21	ϵ	ϵ	NN
cord-312955-gs65c3fy	57	22	and	and	CC
cord-312955-gs65c3fy	57	23	b	b	NN
cord-312955-gs65c3fy	57	24	,	,	,
cord-312955-gs65c3fy	57	25	with	with	IN
cord-312955-gs65c3fy	57	26	lower	low	JJR
cord-312955-gs65c3fy	57	27	homology	homology	NN
cord-312955-gs65c3fy	57	28	(	(	-LRB-
cord-312955-gs65c3fy	57	29	30	30	CD
cord-312955-gs65c3fy	57	30	-	-	SYM
cord-312955-gs65c3fy	57	31	50	50	CD
cord-312955-gs65c3fy	57	32	%	%	NN
cord-312955-gs65c3fy	57	33	)	)	-RRB-
cord-312955-gs65c3fy	57	34	.	.	.
cord-312955-gs65c3fy	58	1	All	all	DT
cord-312955-gs65c3fy	58	2	of	of	IN
cord-312955-gs65c3fy	58	3	them	-PRON-	PRP
cord-312955-gs65c3fy	58	4	bind	bind	VBP
cord-312955-gs65c3fy	58	5	the	the	DT
cord-312955-gs65c3fy	58	6	receptor	receptor	NN
cord-312955-gs65c3fy	58	7	complex	complex	NN
cord-312955-gs65c3fy	58	8	,	,	,
cord-312955-gs65c3fy	58	9	composed	compose	VBN
cord-312955-gs65c3fy	58	10	of	of	IN
cord-312955-gs65c3fy	58	11	IFNAR1	ifnar1	NN
cord-312955-gs65c3fy	59	1	and	and	CC
cord-312955-gs65c3fy	59	2	IFNAR2	ifnar2	NN
cord-312955-gs65c3fy	59	3	at	at	IN
cord-312955-gs65c3fy	59	4	the	the	DT
cord-312955-gs65c3fy	59	5	same	same	JJ
cord-312955-gs65c3fy	59	6	proximal	proximal	JJ
cord-312955-gs65c3fy	59	7	location	location	NN
cord-312955-gs65c3fy	59	8	(	(	-LRB-
cord-312955-gs65c3fy	59	9	1	1	CD
cord-312955-gs65c3fy	59	10	,	,	,
cord-312955-gs65c3fy	59	11	2	2	CD
cord-312955-gs65c3fy	59	12	,	,	,
cord-312955-gs65c3fy	59	13	33	33	CD
cord-312955-gs65c3fy	59	14	)	)	-RRB-
cord-312955-gs65c3fy	59	15	.	.	.
cord-312955-gs65c3fy	60	1	Despite	despite	IN
cord-312955-gs65c3fy	60	2	structural	structural	JJ
cord-312955-gs65c3fy	60	3	similarities	similarity	NNS
cord-312955-gs65c3fy	60	4	among	among	IN
cord-312955-gs65c3fy	60	5	the	the	DT
cord-312955-gs65c3fy	60	6	ternary	ternary	JJ
cord-312955-gs65c3fy	60	7	IFN	IFN	NNP
cord-312955-gs65c3fy	60	8	-	-	HYPH
cord-312955-gs65c3fy	60	9	I	I	NNP
cord-312955-gs65c3fy	60	10	-	-	HYPH
cord-312955-gs65c3fy	60	11	IFNAR1-IFNAR2	IFNAR1-IFNAR2	NNP
cord-312955-gs65c3fy	60	12	complexes	complex	NNS
cord-312955-gs65c3fy	60	13	,	,	,
cord-312955-gs65c3fy	60	14	IFN	IFN	NNP
cord-312955-gs65c3fy	60	15	-	-	:
cord-312955-gs65c3fy	60	16	Is	be	VBZ
cord-312955-gs65c3fy	60	17	drive	drive	VB
cord-312955-gs65c3fy	60	18	a	a	DT
cord-312955-gs65c3fy	60	19	range	range	NN
cord-312955-gs65c3fy	60	20	of	of	IN
cord-312955-gs65c3fy	60	21	different	different	JJ
cord-312955-gs65c3fy	60	22	activities	activity	NNS
cord-312955-gs65c3fy	60	23	,	,	,
cord-312955-gs65c3fy	60	24	dependent	dependent	JJ
cord-312955-gs65c3fy	60	25	on	on	IN
cord-312955-gs65c3fy	60	26	the	the	DT
cord-312955-gs65c3fy	60	27	cell	cell	NN
cord-312955-gs65c3fy	60	28	type	type	NN
cord-312955-gs65c3fy	60	29	and	and	CC
cord-312955-gs65c3fy	60	30	the	the	DT
cord-312955-gs65c3fy	60	31	interferon	interferon	NN
cord-312955-gs65c3fy	60	32	subtype	subtype	NN
cord-312955-gs65c3fy	60	33	(	(	-LRB-
cord-312955-gs65c3fy	60	34	34	34	CD
cord-312955-gs65c3fy	60	35	)	)	-RRB-
cord-312955-gs65c3fy	60	36	.	.	.
cord-312955-gs65c3fy	61	1	This	this	DT
cord-312955-gs65c3fy	61	2	apparent	apparent	JJ
cord-312955-gs65c3fy	61	3	paradox	paradox	NN
cord-312955-gs65c3fy	61	4	has	have	VBZ
cord-312955-gs65c3fy	61	5	major	major	JJ
cord-312955-gs65c3fy	61	6	implications	implication	NNS
cord-312955-gs65c3fy	61	7	for	for	IN
cord-312955-gs65c3fy	61	8	understanding	understand	VBG
cord-312955-gs65c3fy	61	9	the	the	DT
cord-312955-gs65c3fy	61	10	role	role	NN
cord-312955-gs65c3fy	61	11	of	of	IN
cord-312955-gs65c3fy	61	12	IFN	IFN	NNP
cord-312955-gs65c3fy	61	13	-	-	HYPH
cord-312955-gs65c3fy	61	14	I	I	NNP
cord-312955-gs65c3fy	61	15	in	in	IN
cord-312955-gs65c3fy	61	16	health	health	NN
cord-312955-gs65c3fy	61	17	and	and	CC
cord-312955-gs65c3fy	61	18	disease	disease	NN
cord-312955-gs65c3fy	61	19	and	and	CC
cord-312955-gs65c3fy	61	20	its	-PRON-	PRP$
cord-312955-gs65c3fy	61	21	varied	varied	JJ
cord-312955-gs65c3fy	61	22	applications	application	NNS
cord-312955-gs65c3fy	61	23	as	as	IN
cord-312955-gs65c3fy	61	24	a	a	DT
cord-312955-gs65c3fy	61	25	drug	drug	NN
cord-312955-gs65c3fy	61	26	against	against	IN
cord-312955-gs65c3fy	61	27	a	a	DT
cord-312955-gs65c3fy	61	28	pleiotropy	pleiotropy	NN
cord-312955-gs65c3fy	61	29	of	of	IN
cord-312955-gs65c3fy	61	30	diseases	disease	NNS
cord-312955-gs65c3fy	61	31	.	.	.
cord-312955-gs65c3fy	62	1	IFN	IFN	NNP
cord-312955-gs65c3fy	62	2	-	-	HYPH
cord-312955-gs65c3fy	62	3	I	I	NNP
cord-312955-gs65c3fy	62	4	signaling	signaling	NN
cord-312955-gs65c3fy	62	5	is	be	VBZ
cord-312955-gs65c3fy	62	6	initiated	initiate	VBN
cord-312955-gs65c3fy	62	7	by	by	IN
cord-312955-gs65c3fy	62	8	binding	bind	VBG
cord-312955-gs65c3fy	62	9	of	of	IN
cord-312955-gs65c3fy	62	10	IFN	IFN	NNP
cord-312955-gs65c3fy	62	11	-	-	HYPH
cord-312955-gs65c3fy	62	12	I	I	NNP
cord-312955-gs65c3fy	62	13	to	to	IN
cord-312955-gs65c3fy	62	14	its	-PRON-	PRP$
cord-312955-gs65c3fy	62	15	receptor	receptor	NN
cord-312955-gs65c3fy	62	16	.	.	.
cord-312955-gs65c3fy	63	1	It	-PRON-	PRP
cord-312955-gs65c3fy	63	2	has	have	VBZ
cord-312955-gs65c3fy	63	3	been	be	VBN
cord-312955-gs65c3fy	63	4	suggested	suggest	VBN
cord-312955-gs65c3fy	63	5	that	that	IN
cord-312955-gs65c3fy	63	6	cytokine	cytokine	NN
cord-312955-gs65c3fy	63	7	receptors	receptor	NNS
cord-312955-gs65c3fy	63	8	are	be	VBP
cord-312955-gs65c3fy	63	9	pre	pre	JJ
cord-312955-gs65c3fy	63	10	-	-	JJ
cord-312955-gs65c3fy	63	11	associated	associated	JJ
cord-312955-gs65c3fy	63	12	,	,	,
cord-312955-gs65c3fy	63	13	with	with	IN
cord-312955-gs65c3fy	63	14	ligand	ligand	NN
cord-312955-gs65c3fy	63	15	binding	binding	NN
cord-312955-gs65c3fy	63	16	activating	activate	VBG
cord-312955-gs65c3fy	63	17	signaling	signal	VBG
cord-312955-gs65c3fy	63	18	through	through	IN
cord-312955-gs65c3fy	63	19	the	the	DT
cord-312955-gs65c3fy	63	20	induction	induction	NN
cord-312955-gs65c3fy	63	21	of	of	IN
cord-312955-gs65c3fy	63	22	conformational	conformational	JJ
cord-312955-gs65c3fy	63	23	changes	change	NNS
cord-312955-gs65c3fy	63	24	(	(	-LRB-
cord-312955-gs65c3fy	63	25	35	35	CD
cord-312955-gs65c3fy	63	26	)	)	-RRB-
cord-312955-gs65c3fy	63	27	.	.	.
cord-312955-gs65c3fy	64	1	However	however	RB
cord-312955-gs65c3fy	64	2	,	,	,
cord-312955-gs65c3fy	64	3	more	more	RBR
cord-312955-gs65c3fy	64	4	recent	recent	JJ
cord-312955-gs65c3fy	64	5	singlemolecule	singlemolecule	JJ
cord-312955-gs65c3fy	64	6	receptor	receptor	NN
cord-312955-gs65c3fy	64	7	tracking	tracking	NN
cord-312955-gs65c3fy	64	8	on	on	IN
cord-312955-gs65c3fy	64	9	life	life	NN
cord-312955-gs65c3fy	64	10	cells	cell	NNS
cord-312955-gs65c3fy	64	11	has	have	VBZ
cord-312955-gs65c3fy	64	12	clearly	clearly	RB
cord-312955-gs65c3fy	64	13	shown	show	VBN
cord-312955-gs65c3fy	64	14	that	that	IN
cord-312955-gs65c3fy	64	15	for	for	IN
cord-312955-gs65c3fy	64	16	many	many	JJ
cord-312955-gs65c3fy	64	17	of	of	IN
cord-312955-gs65c3fy	64	18	the	the	DT
cord-312955-gs65c3fy	64	19	cytokines	cytokine	NNS
cord-312955-gs65c3fy	64	20	,	,	,
cord-312955-gs65c3fy	64	21	its	-PRON-	PRP$
cord-312955-gs65c3fy	64	22	role	role	NN
cord-312955-gs65c3fy	64	23	is	be	VBZ
cord-312955-gs65c3fy	64	24	to	to	TO
cord-312955-gs65c3fy	64	25	bring	bring	VB
cord-312955-gs65c3fy	64	26	the	the	DT
cord-312955-gs65c3fy	64	27	receptors	receptor	NNS
cord-312955-gs65c3fy	64	28	into	into	IN
cord-312955-gs65c3fy	64	29	close	close	JJ
cord-312955-gs65c3fy	64	30	proximity	proximity	NN
cord-312955-gs65c3fy	64	31	,	,	,
cord-312955-gs65c3fy	64	32	which	which	WDT
cord-312955-gs65c3fy	64	33	drives	drive	VBZ
cord-312955-gs65c3fy	64	34	signaling	signal	VBG
cord-312955-gs65c3fy	64	35	(	(	-LRB-
cord-312955-gs65c3fy	64	36	36	36	CD
cord-312955-gs65c3fy	64	37	)	)	-RRB-
cord-312955-gs65c3fy	64	38	.	.	.
cord-312955-gs65c3fy	65	1	This	this	DT
cord-312955-gs65c3fy	65	2	seems	seem	VBZ
cord-312955-gs65c3fy	65	3	to	to	TO
cord-312955-gs65c3fy	65	4	be	be	VB
cord-312955-gs65c3fy	65	5	the	the	DT
cord-312955-gs65c3fy	65	6	case	case	NN
cord-312955-gs65c3fy	65	7	also	also	RB
cord-312955-gs65c3fy	65	8	for	for	IN
cord-312955-gs65c3fy	65	9	IFN	IFN	NNP
cord-312955-gs65c3fy	65	10	-	-	HYPH
cord-312955-gs65c3fy	65	11	I	I	NNP
cord-312955-gs65c3fy	65	12	induction	induction	NN
cord-312955-gs65c3fy	65	13	,	,	,
cord-312955-gs65c3fy	65	14	as	as	IN
cord-312955-gs65c3fy	65	15	shown	show	VBN
cord-312955-gs65c3fy	65	16	both	both	CC
cord-312955-gs65c3fy	65	17	using	use	VBG
cord-312955-gs65c3fy	65	18	single	single	JJ
cord-312955-gs65c3fy	65	19	receptor	receptor	NN
cord-312955-gs65c3fy	65	20	tracking	tracking	NN
cord-312955-gs65c3fy	65	21	and	and	CC
cord-312955-gs65c3fy	65	22	mutational	mutational	JJ
cord-312955-gs65c3fy	65	23	analysis	analysis	NN
cord-312955-gs65c3fy	65	24	(	(	-LRB-
cord-312955-gs65c3fy	65	25	Figure	figure	NN
cord-312955-gs65c3fy	65	26	1	1	CD
cord-312955-gs65c3fy	65	27	)	)	-RRB-
cord-312955-gs65c3fy	65	28	(	(	-LRB-
cord-312955-gs65c3fy	65	29	37	37	CD
cord-312955-gs65c3fy	65	30	,	,	,
cord-312955-gs65c3fy	65	31	38	38	CD
cord-312955-gs65c3fy	65	32	)	)	-RRB-
cord-312955-gs65c3fy	65	33	.	.	.
cord-312955-gs65c3fy	66	1	While	while	IN
cord-312955-gs65c3fy	66	2	structurally	structurally	RB
cord-312955-gs65c3fy	66	3	,	,	,
cord-312955-gs65c3fy	66	4	the	the	DT
cord-312955-gs65c3fy	66	5	ternary	ternary	JJ
cord-312955-gs65c3fy	66	6	ligand	ligand	NN
cord-312955-gs65c3fy	66	7	-	-	HYPH
cord-312955-gs65c3fy	66	8	receptor	receptor	NN
cord-312955-gs65c3fy	66	9	complex	complex	NN
cord-312955-gs65c3fy	66	10	seems	seem	VBZ
cord-312955-gs65c3fy	66	11	to	to	TO
cord-312955-gs65c3fy	66	12	be	be	VB
cord-312955-gs65c3fy	66	13	the	the	DT
cord-312955-gs65c3fy	66	14	same	same	JJ
cord-312955-gs65c3fy	66	15	for	for	IN
cord-312955-gs65c3fy	66	16	all	all	DT
cord-312955-gs65c3fy	66	17	IFN	IFN	NNP
cord-312955-gs65c3fy	66	18	-	-	HYPH
cord-312955-gs65c3fy	66	19	Is	be	VBZ
cord-312955-gs65c3fy	66	20	,	,	,
cord-312955-gs65c3fy	66	21	the	the	DT
cord-312955-gs65c3fy	66	22	binding	bind	VBG
cord-312955-gs65c3fy	66	23	affinity	affinity	NN
cord-312955-gs65c3fy	66	24	differs	differ	VBZ
cord-312955-gs65c3fy	66	25	by	by	IN
cord-312955-gs65c3fy	66	26	many	many	JJ
cord-312955-gs65c3fy	66	27	orders	order	NNS
cord-312955-gs65c3fy	66	28	of	of	IN
cord-312955-gs65c3fy	66	29	magnitude	magnitude	NN
cord-312955-gs65c3fy	66	30	.	.	.
cord-312955-gs65c3fy	67	1	The	the	DT
cord-312955-gs65c3fy	67	2	tightest	tight	JJS
cord-312955-gs65c3fy	67	3	binding	bind	VBG
cord-312955-gs65c3fy	67	4	IFN	IFN	NNP
cord-312955-gs65c3fy	67	5	-	-	HYPH
cord-312955-gs65c3fy	67	6	I	-PRON-	PRP
cord-312955-gs65c3fy	67	7	is	be	VBZ
cord-312955-gs65c3fy	67	8	IFNb	IFNb	NNS
cord-312955-gs65c3fy	67	9	,	,	,
cord-312955-gs65c3fy	67	10	which	which	WDT
cord-312955-gs65c3fy	67	11	binds	bind	VBZ
cord-312955-gs65c3fy	67	12	IFNAR1	IFNAR1	NNP
cord-312955-gs65c3fy	67	13	with	with	IN
cord-312955-gs65c3fy	67	14	100	100	CD
cord-312955-gs65c3fy	67	15	nM	nm	CD
cord-312955-gs65c3fy	67	16	affinity	affinity	NN
cord-312955-gs65c3fy	67	17	and	and	CC
cord-312955-gs65c3fy	67	18	IFNAR2	ifnar2	NN
cord-312955-gs65c3fy	67	19	with	with	IN
cord-312955-gs65c3fy	67	20	subnanomolar	subnanomolar	NNP
cord-312955-gs65c3fy	67	21	affinity	affinity	NNP
cord-312955-gs65c3fy	67	22	.	.	.
cord-312955-gs65c3fy	68	1	The	the	DT
cord-312955-gs65c3fy	68	2	different	different	JJ
cord-312955-gs65c3fy	68	3	IFNa	IFNa	NNS
cord-312955-gs65c3fy	68	4	subtypes	subtype	NNS
cord-312955-gs65c3fy	68	5	bind	bind	VBP
cord-312955-gs65c3fy	68	6	IFNAR1	ifnar1	PRP
cord-312955-gs65c3fy	68	7	with	with	IN
cord-312955-gs65c3fy	68	8	0.5	0.5	CD
cord-312955-gs65c3fy	68	9	to	to	TO
cord-312955-gs65c3fy	68	10	5	5	CD
cord-312955-gs65c3fy	68	11	µM	µm	CD
cord-312955-gs65c3fy	68	12	affinity	affinity	NN
cord-312955-gs65c3fy	68	13	and	and	CC
cord-312955-gs65c3fy	68	14	IFNAR2	ifnar2	NN
cord-312955-gs65c3fy	68	15	with	with	IN
cord-312955-gs65c3fy	68	16	1	1	CD
cord-312955-gs65c3fy	68	17	to	to	IN
cord-312955-gs65c3fy	68	18	100	100	CD
cord-312955-gs65c3fy	68	19	nM	nm	NN
cord-312955-gs65c3fy	68	20	affinity	affinity	NN
cord-312955-gs65c3fy	68	21	,	,	,
cord-312955-gs65c3fy	68	22	with	with	IN
cord-312955-gs65c3fy	68	23	IFNa1	ifna1	IN
cord-312955-gs65c3fy	68	24	being	be	VBG
cord-312955-gs65c3fy	68	25	the	the	DT
cord-312955-gs65c3fy	68	26	weakest	weak	JJS
cord-312955-gs65c3fy	68	27	binding	bind	VBG
cord-312955-gs65c3fy	68	28	IFNa	IFNa	NNS
cord-312955-gs65c3fy	68	29	(	(	-LRB-
cord-312955-gs65c3fy	68	30	39	39	CD
cord-312955-gs65c3fy	68	31	,	,	,
cord-312955-gs65c3fy	68	32	40	40	CD
cord-312955-gs65c3fy	68	33	)	)	-RRB-
cord-312955-gs65c3fy	68	34	.	.	.
cord-312955-gs65c3fy	69	1	Even	even	RB
cord-312955-gs65c3fy	69	2	weaker	weak	JJR
cord-312955-gs65c3fy	69	3	binding	binding	NN
cord-312955-gs65c3fy	69	4	was	be	VBD
cord-312955-gs65c3fy	69	5	measured	measure	VBN
cord-312955-gs65c3fy	69	6	for	for	IN
cord-312955-gs65c3fy	69	7	IFNϵ	IFNϵ	NNS
cord-312955-gs65c3fy	69	8	,	,	,
cord-312955-gs65c3fy	69	9	with~100-fold	with~100-fold	NNP
cord-312955-gs65c3fy	69	10	reduced	reduce	VBN
cord-312955-gs65c3fy	69	11	affinity	affinity	NN
cord-312955-gs65c3fy	69	12	relative	relative	NN
cord-312955-gs65c3fy	69	13	to	to	IN
cord-312955-gs65c3fy	69	14	IFNa	ifna	NN
cord-312955-gs65c3fy	69	15	proteins	protein	NNS
cord-312955-gs65c3fy	69	16	(	(	-LRB-
cord-312955-gs65c3fy	69	17	15	15	CD
cord-312955-gs65c3fy	69	18	)	)	-RRB-
cord-312955-gs65c3fy	69	19	.	.	.
cord-312955-gs65c3fy	70	1	Interestingly	interestingly	RB
cord-312955-gs65c3fy	70	2	,	,	,
cord-312955-gs65c3fy	70	3	IFNϵ	IFNϵ	NNS
cord-312955-gs65c3fy	70	4	is	be	VBZ
cord-312955-gs65c3fy	70	5	constitutively	constitutively	RB
cord-312955-gs65c3fy	70	6	expressed	express	VBN
cord-312955-gs65c3fy	70	7	by	by	IN
cord-312955-gs65c3fy	70	8	the	the	DT
cord-312955-gs65c3fy	70	9	reproductive	reproductive	JJ
cord-312955-gs65c3fy	70	10	tract	tract	NN
cord-312955-gs65c3fy	70	11	epithelium	epithelium	NN
cord-312955-gs65c3fy	70	12	and	and	CC
cord-312955-gs65c3fy	70	13	is	be	VBZ
cord-312955-gs65c3fy	70	14	regulated	regulate	VBN
cord-312955-gs65c3fy	70	15	by	by	IN
cord-312955-gs65c3fy	70	16	hormones	hormone	NNS
cord-312955-gs65c3fy	70	17	during	during	IN
cord-312955-gs65c3fy	70	18	the	the	DT
cord-312955-gs65c3fy	70	19	estrus	estrus	NN
cord-312955-gs65c3fy	70	20	cycle	cycle	NN
cord-312955-gs65c3fy	70	21	,	,	,
cord-312955-gs65c3fy	70	22	reproduction	reproduction	NN
cord-312955-gs65c3fy	70	23	,	,	,
cord-312955-gs65c3fy	70	24	menopause	menopause	NN
cord-312955-gs65c3fy	70	25	and	and	CC
cord-312955-gs65c3fy	70	26	by	by	IN
cord-312955-gs65c3fy	70	27	exogenous	exogenous	JJ
cord-312955-gs65c3fy	70	28	hormones	hormone	NNS
cord-312955-gs65c3fy	70	29	.	.	.
cord-312955-gs65c3fy	71	1	Thus	thus	RB
cord-312955-gs65c3fy	71	2	,	,	,
cord-312955-gs65c3fy	71	3	its	-PRON-	PRP$
cord-312955-gs65c3fy	71	4	mode	mode	NN
cord-312955-gs65c3fy	71	5	of	of	IN
cord-312955-gs65c3fy	71	6	action	action	NN
cord-312955-gs65c3fy	71	7	is	be	VBZ
cord-312955-gs65c3fy	71	8	different	different	JJ
cord-312955-gs65c3fy	71	9	from	from	IN
cord-312955-gs65c3fy	71	10	other	other	JJ
cord-312955-gs65c3fy	71	11	IFN	IFN	NNP
cord-312955-gs65c3fy	71	12	-	-	:
cord-312955-gs65c3fy	71	13	Is	be	VBZ
cord-312955-gs65c3fy	71	14	(	(	-LRB-
cord-312955-gs65c3fy	71	15	41	41	CD
cord-312955-gs65c3fy	71	16	)	)	-RRB-
cord-312955-gs65c3fy	71	17	.	.	.
cord-312955-gs65c3fy	72	1	These	these	DT
cord-312955-gs65c3fy	72	2	large	large	JJ
cord-312955-gs65c3fy	72	3	differences	difference	NNS
cord-312955-gs65c3fy	72	4	in	in	IN
cord-312955-gs65c3fy	72	5	binding	bind	VBG
cord-312955-gs65c3fy	72	6	affinity	affinity	NN
cord-312955-gs65c3fy	72	7	between	between	IN
cord-312955-gs65c3fy	72	8	IFN	IFN	NNP
cord-312955-gs65c3fy	72	9	-	-	HYPH
cord-312955-gs65c3fy	72	10	I	-PRON-	PRP
cord-312955-gs65c3fy	72	11	subtypes	subtype	NNS
cord-312955-gs65c3fy	72	12	were	be	VBD
cord-312955-gs65c3fy	72	13	suggested	suggest	VBN
cord-312955-gs65c3fy	72	14	to	to	TO
cord-312955-gs65c3fy	72	15	result	result	VB
cord-312955-gs65c3fy	72	16	in	in	IN
cord-312955-gs65c3fy	72	17	major	major	JJ
cord-312955-gs65c3fy	72	18	differences	difference	NNS
cord-312955-gs65c3fy	72	19	in	in	IN
cord-312955-gs65c3fy	72	20	biological	biological	JJ
cord-312955-gs65c3fy	72	21	activity	activity	NN
cord-312955-gs65c3fy	72	22	.	.	.
cord-312955-gs65c3fy	73	1	To	to	TO
cord-312955-gs65c3fy	73	2	obtain	obtain	VB
cord-312955-gs65c3fy	73	3	a	a	DT
cord-312955-gs65c3fy	73	4	better	well	JJR
cord-312955-gs65c3fy	73	5	insight	insight	NN
cord-312955-gs65c3fy	73	6	into	into	IN
cord-312955-gs65c3fy	73	7	the	the	DT
cord-312955-gs65c3fy	73	8	molecular	molecular	JJ
cord-312955-gs65c3fy	73	9	mechanisms	mechanism	NNS
cord-312955-gs65c3fy	73	10	of	of	IN
cord-312955-gs65c3fy	73	11	their	-PRON-	PRP$
cord-312955-gs65c3fy	73	12	actions	action	NNS
cord-312955-gs65c3fy	73	13	,	,	,
cord-312955-gs65c3fy	73	14	IFNa2	IFNa2	NNP
cord-312955-gs65c3fy	73	15	was	be	VBD
cord-312955-gs65c3fy	73	16	engineered	engineer	VBN
cord-312955-gs65c3fy	73	17	to	to	TO
cord-312955-gs65c3fy	73	18	cover	cover	VB
cord-312955-gs65c3fy	73	19	the	the	DT
cord-312955-gs65c3fy	73	20	whole	whole	JJ
cord-312955-gs65c3fy	73	21	range	range	NN
cord-312955-gs65c3fy	73	22	of	of	IN
cord-312955-gs65c3fy	73	23	binding	bind	VBG
cord-312955-gs65c3fy	73	24	affinities	affinity	NNS
cord-312955-gs65c3fy	73	25	of	of	IN
cord-312955-gs65c3fy	73	26	natural	natural	JJ
cord-312955-gs65c3fy	73	27	IFN	IFN	NNP
cord-312955-gs65c3fy	73	28	-	-	,
cord-312955-gs65c3fy	73	29	Is	be	VBZ
cord-312955-gs65c3fy	73	30	to	to	IN
cord-312955-gs65c3fy	73	31	both	both	CC
cord-312955-gs65c3fy	73	32	the	the	DT
cord-312955-gs65c3fy	73	33	high	high	JJ
cord-312955-gs65c3fy	73	34	affinity	affinity	NN
cord-312955-gs65c3fy	73	35	(	(	-LRB-
cord-312955-gs65c3fy	73	36	IFNAR2	ifnar2	NN
cord-312955-gs65c3fy	73	37	)	)	-RRB-
cord-312955-gs65c3fy	73	38	and	and	CC
cord-312955-gs65c3fy	73	39	low	low	JJ
cord-312955-gs65c3fy	73	40	affinity	affinity	NN
cord-312955-gs65c3fy	73	41	(	(	-LRB-
cord-312955-gs65c3fy	73	42	IFNAR1	ifnar1	NN
cord-312955-gs65c3fy	73	43	)	)	-RRB-
cord-312955-gs65c3fy	73	44	receptor	receptor	NN
cord-312955-gs65c3fy	73	45	chains	chain	NNS
cord-312955-gs65c3fy	73	46	(	(	-LRB-
cord-312955-gs65c3fy	73	47	1	1	CD
cord-312955-gs65c3fy	73	48	)	)	-RRB-
cord-312955-gs65c3fy	73	49	.	.	.
cord-312955-gs65c3fy	74	1	These	these	DT
cord-312955-gs65c3fy	74	2	studies	study	NNS
cord-312955-gs65c3fy	74	3	have	have	VBP
cord-312955-gs65c3fy	74	4	shown	show	VBN
cord-312955-gs65c3fy	74	5	that	that	IN
cord-312955-gs65c3fy	74	6	indeed	indeed	RB
cord-312955-gs65c3fy	74	7	,	,	,
cord-312955-gs65c3fy	74	8	the	the	DT
cord-312955-gs65c3fy	74	9	binding	bind	VBG
cord-312955-gs65c3fy	74	10	affinity	affinity	NN
cord-312955-gs65c3fy	74	11	to	to	IN
cord-312955-gs65c3fy	74	12	both	both	DT
cord-312955-gs65c3fy	74	13	receptors	receptor	NNS
cord-312955-gs65c3fy	74	14	is	be	VBZ
cord-312955-gs65c3fy	74	15	a	a	DT
cord-312955-gs65c3fy	74	16	major	major	JJ
cord-312955-gs65c3fy	74	17	determinant	determinant	NN
cord-312955-gs65c3fy	74	18	of	of	IN
cord-312955-gs65c3fy	74	19	IFN	IFN	NNP
cord-312955-gs65c3fy	74	20	-	-	HYPH
cord-312955-gs65c3fy	74	21	I	I	NNP
cord-312955-gs65c3fy	74	22	activity	activity	NN
cord-312955-gs65c3fy	74	23	(	(	-LRB-
cord-312955-gs65c3fy	74	24	42	42	CD
cord-312955-gs65c3fy	74	25	)	)	-RRB-
cord-312955-gs65c3fy	74	26	.	.	.
cord-312955-gs65c3fy	75	1	Using	use	VBG
cord-312955-gs65c3fy	75	2	both	both	DT
cord-312955-gs65c3fy	75	3	natural	natural	JJ
cord-312955-gs65c3fy	75	4	and	and	CC
cord-312955-gs65c3fy	75	5	engineered	engineer	VBD
cord-312955-gs65c3fy	75	6	IFN	IFN	NNP
cord-312955-gs65c3fy	75	7	-	-	HYPH
cord-312955-gs65c3fy	75	8	Is	be	VBZ
cord-312955-gs65c3fy	75	9	has	have	VBZ
cord-312955-gs65c3fy	75	10	shown	show	VBN
cord-312955-gs65c3fy	75	11	that	that	IN
cord-312955-gs65c3fy	75	12	even	even	RB
cord-312955-gs65c3fy	75	13	weak	weak	JJ
cord-312955-gs65c3fy	75	14	binding	bind	VBG
cord-312955-gs65c3fy	75	15	IFN	IFN	NNP
cord-312955-gs65c3fy	75	16	-	-	:
cord-312955-gs65c3fy	75	17	Is	be	VBZ
cord-312955-gs65c3fy	75	18	activate	activate	VB
cord-312955-gs65c3fy	75	19	the	the	DT
cord-312955-gs65c3fy	75	20	cellular	cellular	JJ
cord-312955-gs65c3fy	75	21	antiviral	antiviral	JJ
cord-312955-gs65c3fy	75	22	program	program	NN
cord-312955-gs65c3fy	75	23	at	at	IN
cord-312955-gs65c3fy	75	24	very	very	RB
cord-312955-gs65c3fy	75	25	low	low	JJ
cord-312955-gs65c3fy	75	26	(	(	-LRB-
cord-312955-gs65c3fy	75	27	pM	pm	NN
cord-312955-gs65c3fy	75	28	)	)	-RRB-
cord-312955-gs65c3fy	75	29	concentrations	concentration	NNS
cord-312955-gs65c3fy	75	30	(	(	-LRB-
cord-312955-gs65c3fy	75	31	39	39	CD
cord-312955-gs65c3fy	75	32	)	)	-RRB-
cord-312955-gs65c3fy	75	33	.	.	.
cord-312955-gs65c3fy	76	1	Moreover	moreover	RB
cord-312955-gs65c3fy	76	2	,	,	,
cord-312955-gs65c3fy	76	3	the	the	DT
cord-312955-gs65c3fy	76	4	antiviral	antiviral	JJ
cord-312955-gs65c3fy	76	5	program	program	NN
cord-312955-gs65c3fy	76	6	was	be	VBD
cord-312955-gs65c3fy	76	7	activated	activate	VBN
cord-312955-gs65c3fy	76	8	in	in	IN
cord-312955-gs65c3fy	76	9	all	all	DT
cord-312955-gs65c3fy	76	10	cell	cell	NN
cord-312955-gs65c3fy	76	11	-	-	HYPH
cord-312955-gs65c3fy	76	12	lines	line	NNS
cord-312955-gs65c3fy	76	13	tested	test	VBN
cord-312955-gs65c3fy	76	14	.	.	.
cord-312955-gs65c3fy	77	1	Despite	despite	IN
cord-312955-gs65c3fy	77	2	the	the	DT
cord-312955-gs65c3fy	77	3	50-fold	50-fold	CD
cord-312955-gs65c3fy	77	4	higher	high	JJR
cord-312955-gs65c3fy	77	5	affinity	affinity	NN
cord-312955-gs65c3fy	77	6	of	of	IN
cord-312955-gs65c3fy	77	7	IFNb	IFNb	NNS
cord-312955-gs65c3fy	77	8	over	over	IN
cord-312955-gs65c3fy	77	9	IFNa2	IFNa2	NNP
cord-312955-gs65c3fy	77	10	towards	towards	IN
cord-312955-gs65c3fy	77	11	binding	bind	VBG
cord-312955-gs65c3fy	77	12	IFNAR	IFNAR	NNP
cord-312955-gs65c3fy	77	13	receptors	receptor	NNS
cord-312955-gs65c3fy	77	14	,	,	,
cord-312955-gs65c3fy	77	15	its	-PRON-	PRP$
cord-312955-gs65c3fy	77	16	potency	potency	NN
cord-312955-gs65c3fy	77	17	to	to	TO
cord-312955-gs65c3fy	77	18	elicit	elicit	VB
cord-312955-gs65c3fy	77	19	an	an	DT
cord-312955-gs65c3fy	77	20	antiviral	antiviral	JJ
cord-312955-gs65c3fy	77	21	response	response	NN
cord-312955-gs65c3fy	77	22	is	be	VBZ
cord-312955-gs65c3fy	77	23	similar	similar	JJ
cord-312955-gs65c3fy	77	24	.	.	.
cord-312955-gs65c3fy	78	1	For	for	IN
cord-312955-gs65c3fy	78	2	example	example	NN
cord-312955-gs65c3fy	78	3	,	,	,
cord-312955-gs65c3fy	78	4	in	in	IN
cord-312955-gs65c3fy	78	5	WISH	wish	NN
cord-312955-gs65c3fy	78	6	cells	cell	NNS
cord-312955-gs65c3fy	78	7	(	(	-LRB-
cord-312955-gs65c3fy	78	8	originally	originally	RB
cord-312955-gs65c3fy	78	9	thought	think	VBN
cord-312955-gs65c3fy	78	10	to	to	TO
cord-312955-gs65c3fy	78	11	be	be	VB
cord-312955-gs65c3fy	78	12	of	of	IN
cord-312955-gs65c3fy	78	13	amniotic	amniotic	JJ
cord-312955-gs65c3fy	78	14	origin	origin	NN
cord-312955-gs65c3fy	78	15	,	,	,
cord-312955-gs65c3fy	78	16	but	but	CC
cord-312955-gs65c3fy	78	17	later	later	RB
cord-312955-gs65c3fy	78	18	found	find	VBD
cord-312955-gs65c3fy	78	19	to	to	TO
cord-312955-gs65c3fy	78	20	be	be	VB
cord-312955-gs65c3fy	78	21	a	a	DT
cord-312955-gs65c3fy	78	22	HeLa	HeLa	NNP
cord-312955-gs65c3fy	78	23	(	(	-LRB-
cord-312955-gs65c3fy	78	24	cervix	cervix	NN
cord-312955-gs65c3fy	78	25	cancer	cancer	NN
cord-312955-gs65c3fy	78	26	)	)	-RRB-
cord-312955-gs65c3fy	78	27	contaminant	contaminant	NN
cord-312955-gs65c3fy	78	28	)	)	-RRB-
cord-312955-gs65c3fy	79	1	the	the	DT
cord-312955-gs65c3fy	79	2	EC	EC	NNP
cord-312955-gs65c3fy	79	3	50	50	CD
cord-312955-gs65c3fy	79	4	for	for	IN
cord-312955-gs65c3fy	79	5	antiviral	antiviral	JJ
cord-312955-gs65c3fy	79	6	activity	activity	NN
cord-312955-gs65c3fy	79	7	of	of	IN
cord-312955-gs65c3fy	79	8	IFNa2	IFNa2	NNP
cord-312955-gs65c3fy	79	9	is	be	VBZ
cord-312955-gs65c3fy	79	10	0.3	0.3	CD
cord-312955-gs65c3fy	79	11	pM	pm	NN
cord-312955-gs65c3fy	79	12	,	,	,
cord-312955-gs65c3fy	79	13	while	while	IN
cord-312955-gs65c3fy	79	14	the	the	DT
cord-312955-gs65c3fy	79	15	EC	EC	NNP
cord-312955-gs65c3fy	79	16	50	50	CD
cord-312955-gs65c3fy	79	17	for	for	IN
cord-312955-gs65c3fy	79	18	IFNb	IFNb	NNS
cord-312955-gs65c3fy	79	19	is	be	VBZ
cord-312955-gs65c3fy	79	20	0.15	0.15	CD
cord-312955-gs65c3fy	79	21	pM	pm	NN
cord-312955-gs65c3fy	80	1	(	(	-LRB-
cord-312955-gs65c3fy	80	2	43	43	CD
cord-312955-gs65c3fy	80	3	)	)	-RRB-
cord-312955-gs65c3fy	80	4	.	.	.
cord-312955-gs65c3fy	81	1	WISH	wish	VBP
cord-312955-gs65c3fy	81	2	cells	cell	NNS
cord-312955-gs65c3fy	81	3	have	have	VBP
cord-312955-gs65c3fy	81	4	been	be	VBN
cord-312955-gs65c3fy	81	5	extensively	extensively	RB
cord-312955-gs65c3fy	81	6	used	use	VBN
cord-312955-gs65c3fy	81	7	to	to	TO
cord-312955-gs65c3fy	81	8	characterize	characterize	VB
cord-312955-gs65c3fy	81	9	IFN	IFN	NNP
cord-312955-gs65c3fy	81	10	-	-	HYPH
cord-312955-gs65c3fy	81	11	I	I	NNP
cord-312955-gs65c3fy	81	12	activity	activity	NN
cord-312955-gs65c3fy	81	13	,	,	,
cord-312955-gs65c3fy	81	14	including	include	VBG
cord-312955-gs65c3fy	81	15	for	for	IN
cord-312955-gs65c3fy	81	16	definition	definition	NN
cord-312955-gs65c3fy	81	17	of	of	IN
cord-312955-gs65c3fy	81	18	IFN	IFN	NNP
cord-312955-gs65c3fy	81	19	-	-	HYPH
cord-312955-gs65c3fy	81	20	I	-PRON-	PRP
cord-312955-gs65c3fy	81	21	unit	unit	NN
cord-312955-gs65c3fy	81	22	activity	activity	NN
cord-312955-gs65c3fy	81	23	.	.	.
cord-312955-gs65c3fy	82	1	An	an	DT
cord-312955-gs65c3fy	82	2	upper	upper	JJ
cord-312955-gs65c3fy	82	3	limit	limit	NN
cord-312955-gs65c3fy	82	4	for	for	IN
cord-312955-gs65c3fy	82	5	antiviral	antiviral	JJ
cord-312955-gs65c3fy	82	6	potency	potency	NN
cord-312955-gs65c3fy	82	7	was	be	VBD
cord-312955-gs65c3fy	82	8	further	further	RB
cord-312955-gs65c3fy	82	9	verified	verify	VBN
cord-312955-gs65c3fy	82	10	by	by	IN
cord-312955-gs65c3fy	82	11	engineering	engineer	VBG
cord-312955-gs65c3fy	82	12	an	an	DT
cord-312955-gs65c3fy	82	13	IFNa2	ifna2	NN
cord-312955-gs65c3fy	82	14	variant	variant	NN
cord-312955-gs65c3fy	82	15	,	,	,
cord-312955-gs65c3fy	82	16	YNS	YNS	NNP
cord-312955-gs65c3fy	82	17	-	-	HYPH
cord-312955-gs65c3fy	82	18	a8-tail	a8-tail	NNP
cord-312955-gs65c3fy	82	19	,	,	,
cord-312955-gs65c3fy	82	20	with	with	IN
cord-312955-gs65c3fy	82	21	50fold	50fold	RB
cord-312955-gs65c3fy	82	22	tighter	tight	JJR
cord-312955-gs65c3fy	82	23	binding	binding	NN
cord-312955-gs65c3fy	82	24	to	to	IN
cord-312955-gs65c3fy	82	25	IFNAR1	ifnar1	NN
cord-312955-gs65c3fy	82	26	and	and	CC
cord-312955-gs65c3fy	82	27	15-fold	15-fold	VBD
cord-312955-gs65c3fy	82	28	tighter	tight	JJR
cord-312955-gs65c3fy	82	29	binding	binding	NN
cord-312955-gs65c3fy	82	30	to	to	IN
cord-312955-gs65c3fy	82	31	IFNAR2	ifnar2	NN
cord-312955-gs65c3fy	82	32	in	in	IN
cord-312955-gs65c3fy	82	33	comparison	comparison	NN
cord-312955-gs65c3fy	82	34	to	to	IN
cord-312955-gs65c3fy	82	35	IFNa2	IFNa2	NNP
cord-312955-gs65c3fy	82	36	(	(	-LRB-
cord-312955-gs65c3fy	82	37	thereby	thereby	RB
cord-312955-gs65c3fy	82	38	surpassing	surpass	VBG
cord-312955-gs65c3fy	82	39	the	the	DT
cord-312955-gs65c3fy	82	40	receptor	receptor	NN
cord-312955-gs65c3fy	82	41	binding	bind	VBG
cord-312955-gs65c3fy	82	42	affinity	affinity	NN
cord-312955-gs65c3fy	82	43	of	of	IN
cord-312955-gs65c3fy	82	44	natural	natural	JJ
cord-312955-gs65c3fy	82	45	IFNb	IFNb	NNS
cord-312955-gs65c3fy	82	46	)	)	-RRB-
cord-312955-gs65c3fy	82	47	.	.	.
cord-312955-gs65c3fy	83	1	Still	still	RB
cord-312955-gs65c3fy	83	2	,	,	,
cord-312955-gs65c3fy	83	3	the	the	DT
cord-312955-gs65c3fy	83	4	EC	EC	NNP
cord-312955-gs65c3fy	83	5	50	50	CD
cord-312955-gs65c3fy	83	6	for	for	IN
cord-312955-gs65c3fy	83	7	antiviral	antiviral	JJ
cord-312955-gs65c3fy	83	8	activity	activity	NN
cord-312955-gs65c3fy	83	9	is	be	VBZ
cord-312955-gs65c3fy	83	10	only	only	RB
cord-312955-gs65c3fy	83	11	3-fold	3-fold	CD
cord-312955-gs65c3fy	83	12	lower	low	JJR
cord-312955-gs65c3fy	83	13	in	in	IN
cord-312955-gs65c3fy	83	14	comparison	comparison	NN
cord-312955-gs65c3fy	83	15	to	to	IN
cord-312955-gs65c3fy	83	16	IFNa2	IFNa2	NNP
cord-312955-gs65c3fy	83	17	(	(	-LRB-
cord-312955-gs65c3fy	83	18	44	44	CD
cord-312955-gs65c3fy	83	19	,	,	,
cord-312955-gs65c3fy	83	20	45	45	CD
cord-312955-gs65c3fy	83	21	)	)	-RRB-
cord-312955-gs65c3fy	83	22	.	.	.
cord-312955-gs65c3fy	84	1	Conversely	conversely	RB
cord-312955-gs65c3fy	84	2	to	to	IN
cord-312955-gs65c3fy	84	3	antiviral	antiviral	JJ
cord-312955-gs65c3fy	84	4	activity	activity	NN
cord-312955-gs65c3fy	84	5	,	,	,
cord-312955-gs65c3fy	84	6	IFNb	IFNb	NNS
cord-312955-gs65c3fy	84	7	is	be	VBZ
cord-312955-gs65c3fy	84	8	much	much	RB
cord-312955-gs65c3fy	84	9	more	more	RBR
cord-312955-gs65c3fy	84	10	potent	potent	JJ
cord-312955-gs65c3fy	84	11	in	in	IN
cord-312955-gs65c3fy	84	12	activating	activate	VBG
cord-312955-gs65c3fy	84	13	the	the	DT
cord-312955-gs65c3fy	84	14	antiproliferative	antiproliferative	NNP
cord-312955-gs65c3fy	84	15	program	program	NN
cord-312955-gs65c3fy	84	16	relative	relative	JJ
cord-312955-gs65c3fy	84	17	to	to	IN
cord-312955-gs65c3fy	84	18	IFNa2	IFNa2	NNP
cord-312955-gs65c3fy	84	19	,	,	,
cord-312955-gs65c3fy	84	20	a	a	DT
cord-312955-gs65c3fy	84	21	result	result	NN
cord-312955-gs65c3fy	84	22	that	that	WDT
cord-312955-gs65c3fy	84	23	was	be	VBD
cord-312955-gs65c3fy	84	24	also	also	RB
cord-312955-gs65c3fy	84	25	verified	verify	VBN
cord-312955-gs65c3fy	84	26	using	use	VBG
cord-312955-gs65c3fy	84	27	the	the	DT
cord-312955-gs65c3fy	84	28	IFNa2	ifna2	NN
cord-312955-gs65c3fy	84	29	variant	variant	NN
cord-312955-gs65c3fy	84	30	,	,	,
cord-312955-gs65c3fy	84	31	YNS	YNS	NNP
cord-312955-gs65c3fy	84	32	-	-	HYPH
cord-312955-gs65c3fy	84	33	a8tail	a8tail	NNP
cord-312955-gs65c3fy	84	34	(	(	-LRB-
cord-312955-gs65c3fy	84	35	45	45	CD
cord-312955-gs65c3fy	84	36	)	)	-RRB-
cord-312955-gs65c3fy	84	37	.	.	.
cord-312955-gs65c3fy	85	1	The	the	DT
cord-312955-gs65c3fy	85	2	EC	EC	NNP
cord-312955-gs65c3fy	85	3	50	50	CD
cord-312955-gs65c3fy	85	4	for	for	IN
cord-312955-gs65c3fy	85	5	antiproliferative	antiproliferative	JJ
cord-312955-gs65c3fy	85	6	activity	activity	NN
cord-312955-gs65c3fy	85	7	on	on	IN
cord-312955-gs65c3fy	85	8	WISH	wish	NN
cord-312955-gs65c3fy	85	9	cells	cell	NNS
cord-312955-gs65c3fy	85	10	is	be	VBZ
cord-312955-gs65c3fy	85	11	2	2	CD
cord-312955-gs65c3fy	85	12	nM	nm	NN
cord-312955-gs65c3fy	85	13	for	for	IN
cord-312955-gs65c3fy	85	14	IFNa2	IFNa2	NNP
cord-312955-gs65c3fy	85	15	,	,	,
cord-312955-gs65c3fy	85	16	50	50	CD
cord-312955-gs65c3fy	85	17	pM	pm	NN
cord-312955-gs65c3fy	85	18	for	for	IN
cord-312955-gs65c3fy	85	19	IFNb	IFNb	NNS
cord-312955-gs65c3fy	85	20	and	and	CC
cord-312955-gs65c3fy	85	21	20	20	CD
cord-312955-gs65c3fy	85	22	pM	pm	NN
cord-312955-gs65c3fy	85	23	for	for	IN
cord-312955-gs65c3fy	85	24	YNS	YNS	NNP
cord-312955-gs65c3fy	85	25	-	-	HYPH
cord-312955-gs65c3fy	85	26	a8-tail	a8-tail	NNP
cord-312955-gs65c3fy	85	27	.	.	.
cord-312955-gs65c3fy	86	1	A	a	DT
cord-312955-gs65c3fy	86	2	similar	similar	JJ
cord-312955-gs65c3fy	86	3	increase	increase	NN
cord-312955-gs65c3fy	86	4	in	in	IN
cord-312955-gs65c3fy	86	5	antiproliferative	antiproliferative	JJ
cord-312955-gs65c3fy	86	6	potency	potency	NN
cord-312955-gs65c3fy	86	7	was	be	VBD
cord-312955-gs65c3fy	86	8	observed	observe	VBN
cord-312955-gs65c3fy	86	9	also	also	RB
cord-312955-gs65c3fy	86	10	for	for	IN
cord-312955-gs65c3fy	86	11	OVCAR3	OVCAR3	NNP
cord-312955-gs65c3fy	86	12	and	and	CC
cord-312955-gs65c3fy	86	13	HeLa	HeLa	NNP
cord-312955-gs65c3fy	86	14	cells	cell	NNS
cord-312955-gs65c3fy	86	15	.	.	.
cord-312955-gs65c3fy	87	1	Interestingly	interestingly	RB
cord-312955-gs65c3fy	87	2	,	,	,
cord-312955-gs65c3fy	87	3	while	while	IN
cord-312955-gs65c3fy	87	4	antiviral	antiviral	JJ
cord-312955-gs65c3fy	87	5	activity	activity	NN
cord-312955-gs65c3fy	87	6	was	be	VBD
cord-312955-gs65c3fy	87	7	observed	observe	VBN
cord-312955-gs65c3fy	87	8	in	in	IN
cord-312955-gs65c3fy	87	9	all	all	DT
cord-312955-gs65c3fy	87	10	cell	cell	NN
cord-312955-gs65c3fy	87	11	lines	line	NNS
cord-312955-gs65c3fy	87	12	tested	test	VBN
cord-312955-gs65c3fy	87	13	,	,	,
cord-312955-gs65c3fy	87	14	some	some	DT
cord-312955-gs65c3fy	87	15	cell	cell	NN
cord-312955-gs65c3fy	87	16	lines	line	NNS
cord-312955-gs65c3fy	87	17	were	be	VBD
cord-312955-gs65c3fy	87	18	not	not	RB
cord-312955-gs65c3fy	87	19	susceptible	susceptible	JJ
cord-312955-gs65c3fy	87	20	to	to	IN
cord-312955-gs65c3fy	87	21	IFN-	IFN-	NNP
cord-312955-gs65c3fy	88	1	I	-PRON-	PRP
cord-312955-gs65c3fy	88	2	induced	induce	VBD
cord-312955-gs65c3fy	88	3	antiproliferative	antiproliferative	JJ
cord-312955-gs65c3fy	88	4	activity	activity	NN
cord-312955-gs65c3fy	88	5	(	(	-LRB-
cord-312955-gs65c3fy	88	6	for	for	IN
cord-312955-gs65c3fy	88	7	example	example	NN
cord-312955-gs65c3fy	89	1	T47D	T47D	NNP
cord-312955-gs65c3fy	89	2	and	and	CC
cord-312955-gs65c3fy	89	3	K562	k562	CD
cord-312955-gs65c3fy	89	4	)	)	-RRB-
cord-312955-gs65c3fy	89	5	,	,	,
cord-312955-gs65c3fy	89	6	independent	independent	JJ
cord-312955-gs65c3fy	89	7	on	on	IN
cord-312955-gs65c3fy	89	8	the	the	DT
cord-312955-gs65c3fy	89	9	concentration	concentration	NN
cord-312955-gs65c3fy	89	10	and	and	CC
cord-312955-gs65c3fy	89	11	subtype	subtype	NN
cord-312955-gs65c3fy	89	12	of	of	IN
cord-312955-gs65c3fy	89	13	IFN	IFN	NNP
cord-312955-gs65c3fy	89	14	-	-	HYPH
cord-312955-gs65c3fy	89	15	I	I	NNP
cord-312955-gs65c3fy	89	16	(	(	-LRB-
cord-312955-gs65c3fy	89	17	45	45	CD
cord-312955-gs65c3fy	89	18	)	)	-RRB-
cord-312955-gs65c3fy	89	19	.	.	.
cord-312955-gs65c3fy	90	1	To	to	TO
cord-312955-gs65c3fy	90	2	better	well	RBR
cord-312955-gs65c3fy	90	3	understand	understand	VB
cord-312955-gs65c3fy	90	4	the	the	DT
cord-312955-gs65c3fy	90	5	molecular	molecular	JJ
cord-312955-gs65c3fy	90	6	basis	basis	NN
cord-312955-gs65c3fy	90	7	for	for	IN
cord-312955-gs65c3fy	90	8	this	this	DT
cord-312955-gs65c3fy	90	9	finding	finding	NN
cord-312955-gs65c3fy	90	10	,	,	,
cord-312955-gs65c3fy	90	11	IFN	IFN	NNP
cord-312955-gs65c3fy	90	12	-	-	HYPH
cord-312955-gs65c3fy	90	13	I	I	NNP
cord-312955-gs65c3fy	90	14	induced	induce	VBD
cord-312955-gs65c3fy	90	15	gene	gene	NN
cord-312955-gs65c3fy	90	16	expression	expression	NN
cord-312955-gs65c3fy	90	17	was	be	VBD
cord-312955-gs65c3fy	90	18	monitored	monitor	VBN
cord-312955-gs65c3fy	90	19	using	use	VBG
cord-312955-gs65c3fy	90	20	various	various	JJ
cord-312955-gs65c3fy	90	21	IFN	IFN	NNP
cord-312955-gs65c3fy	90	22	-	-	HYPH
cord-312955-gs65c3fy	90	23	I	-PRON-	PRP
cord-312955-gs65c3fy	90	24	subtypes	subtype	NNS
cord-312955-gs65c3fy	90	25	or	or	CC
cord-312955-gs65c3fy	90	26	engineered	engineer	VBN
cord-312955-gs65c3fy	90	27	mutants	mutant	NNS
cord-312955-gs65c3fy	90	28	on	on	IN
cord-312955-gs65c3fy	90	29	the	the	DT
cord-312955-gs65c3fy	90	30	background	background	NN
cord-312955-gs65c3fy	90	31	of	of	IN
cord-312955-gs65c3fy	90	32	different	different	JJ
cord-312955-gs65c3fy	90	33	cell	cell	NN
cord-312955-gs65c3fy	90	34	-	-	HYPH
cord-312955-gs65c3fy	90	35	lines	line	NNS
cord-312955-gs65c3fy	90	36	.	.	.
cord-312955-gs65c3fy	91	1	These	these	DT
cord-312955-gs65c3fy	91	2	experiments	experiment	NNS
cord-312955-gs65c3fy	91	3	showed	show	VBD
cord-312955-gs65c3fy	91	4	that	that	IN
cord-312955-gs65c3fy	91	5	low	low	JJ
cord-312955-gs65c3fy	91	6	concentrations	concentration	NNS
cord-312955-gs65c3fy	91	7	of	of	IN
cord-312955-gs65c3fy	91	8	weaker	weak	JJR
cord-312955-gs65c3fy	91	9	binding	binding	NN
cord-312955-gs65c3fy	91	10	interferons	interferon	NNS
cord-312955-gs65c3fy	91	11	activate	activate	VBP
cord-312955-gs65c3fy	91	12	the	the	DT
cord-312955-gs65c3fy	91	13	expression	expression	NN
cord-312955-gs65c3fy	91	14	of	of	IN
cord-312955-gs65c3fy	91	15	mostly	mostly	RB
cord-312955-gs65c3fy	91	16	antiviral	antiviral	JJ
cord-312955-gs65c3fy	91	17	genes	gene	NNS
cord-312955-gs65c3fy	91	18	.	.	.
cord-312955-gs65c3fy	92	1	Higher	high	JJR
cord-312955-gs65c3fy	92	2	concentrations	concentration	NNS
cord-312955-gs65c3fy	92	3	of	of	IN
cord-312955-gs65c3fy	92	4	interferons	interferon	NNS
cord-312955-gs65c3fy	92	5	activate	activate	VBP
cord-312955-gs65c3fy	92	6	also	also	RB
cord-312955-gs65c3fy	92	7	other	other	JJ
cord-312955-gs65c3fy	92	8	genes	gene	NNS
cord-312955-gs65c3fy	92	9	,	,	,
cord-312955-gs65c3fy	92	10	many	many	JJ
cord-312955-gs65c3fy	92	11	of	of	IN
cord-312955-gs65c3fy	92	12	them	-PRON-	PRP
cord-312955-gs65c3fy	92	13	related	relate	VBN
cord-312955-gs65c3fy	92	14	to	to	IN
cord-312955-gs65c3fy	92	15	immune	immune	JJ
cord-312955-gs65c3fy	92	16	-	-	HYPH
cord-312955-gs65c3fy	92	17	modulation	modulation	NN
cord-312955-gs65c3fy	92	18	(	(	-LRB-
cord-312955-gs65c3fy	92	19	45	45	CD
cord-312955-gs65c3fy	92	20	)	)	-RRB-
cord-312955-gs65c3fy	92	21	.	.	.
cord-312955-gs65c3fy	93	1	Examples	example	NNS
cord-312955-gs65c3fy	93	2	for	for	IN
cord-312955-gs65c3fy	93	3	such	such	JJ
cord-312955-gs65c3fy	93	4	genes	gene	NNS
cord-312955-gs65c3fy	93	5	are	be	VBP
cord-312955-gs65c3fy	93	6	chemokines	chemokine	NNS
cord-312955-gs65c3fy	93	7	such	such	JJ
cord-312955-gs65c3fy	93	8	as	as	IN
cord-312955-gs65c3fy	93	9	CXCL10	CXCL10	NNP
cord-312955-gs65c3fy	93	10	and	and	CC
cord-312955-gs65c3fy	93	11	11	11	CD
cord-312955-gs65c3fy	93	12	,	,	,
cord-312955-gs65c3fy	93	13	which	which	WDT
cord-312955-gs65c3fy	93	14	are	be	VBP
cord-312955-gs65c3fy	93	15	involved	involve	VBN
cord-312955-gs65c3fy	93	16	in	in	IN
cord-312955-gs65c3fy	93	17	chemotaxis	chemotaxis	NN
cord-312955-gs65c3fy	93	18	of	of	IN
cord-312955-gs65c3fy	93	19	T	t	NN
cord-312955-gs65c3fy	93	20	cells	cell	NNS
cord-312955-gs65c3fy	93	21	and	and	CC
cord-312955-gs65c3fy	93	22	natural	natural	JJ
cord-312955-gs65c3fy	93	23	killer	killer	NN
cord-312955-gs65c3fy	93	24	cells	cell	NNS
cord-312955-gs65c3fy	93	25	,	,	,
cord-312955-gs65c3fy	93	26	induction	induction	NN
cord-312955-gs65c3fy	93	27	of	of	IN
cord-312955-gs65c3fy	93	28	apoptosis	apoptosis	NN
cord-312955-gs65c3fy	93	29	,	,	,
cord-312955-gs65c3fy	93	30	regulation	regulation	NN
cord-312955-gs65c3fy	93	31	of	of	IN
cord-312955-gs65c3fy	93	32	cell	cell	NN
cord-312955-gs65c3fy	93	33	growth	growth	NN
cord-312955-gs65c3fy	93	34	and	and	CC
cord-312955-gs65c3fy	93	35	more	more	JJR
cord-312955-gs65c3fy	93	36	.	.	.
cord-312955-gs65c3fy	94	1	We	-PRON-	PRP
cord-312955-gs65c3fy	94	2	gave	give	VBD
cord-312955-gs65c3fy	94	3	the	the	DT
cord-312955-gs65c3fy	94	4	term	term	NN
cord-312955-gs65c3fy	94	5	of	of	IN
cord-312955-gs65c3fy	94	6	"	"	``
cord-312955-gs65c3fy	94	7	robust	robust	JJ
cord-312955-gs65c3fy	94	8	"	"	''
cord-312955-gs65c3fy	94	9	for	for	IN
cord-312955-gs65c3fy	94	10	the	the	DT
cord-312955-gs65c3fy	94	11	common	common	JJ
cord-312955-gs65c3fy	94	12	IFN-	IFN-	NNP
cord-312955-gs65c3fy	95	1	I	-PRON-	PRP
cord-312955-gs65c3fy	95	2	induced	induce	VBD
cord-312955-gs65c3fy	95	3	program	program	NN
cord-312955-gs65c3fy	95	4	(	(	-LRB-
cord-312955-gs65c3fy	95	5	including	include	VBG
cord-312955-gs65c3fy	95	6	its	-PRON-	PRP$
cord-312955-gs65c3fy	95	7	antiviral	antiviral	JJ
cord-312955-gs65c3fy	95	8	activity	activity	NN
cord-312955-gs65c3fy	95	9	)	)	-RRB-
cord-312955-gs65c3fy	95	10	and	and	CC
cord-312955-gs65c3fy	95	11	"	"	``
cord-312955-gs65c3fy	95	12	tunable	tunable	JJ
cord-312955-gs65c3fy	95	13	"	"	''
cord-312955-gs65c3fy	95	14	for	for	IN
cord-312955-gs65c3fy	95	15	the	the	DT
cord-312955-gs65c3fy	95	16	other	other	JJ
cord-312955-gs65c3fy	95	17	programs	program	NNS
cord-312955-gs65c3fy	95	18	induced	induce	VBN
cord-312955-gs65c3fy	95	19	by	by	IN
cord-312955-gs65c3fy	95	20	IFN	IFN	NNP
cord-312955-gs65c3fy	95	21	-	-	HYPH
cord-312955-gs65c3fy	95	22	Is	Is	NNP
cord-312955-gs65c3fy	95	23	,	,	,
cord-312955-gs65c3fy	95	24	which	which	WDT
cord-312955-gs65c3fy	95	25	include	include	VBP
cord-312955-gs65c3fy	95	26	between	between	IN
cord-312955-gs65c3fy	95	27	others	other	NNS
cord-312955-gs65c3fy	95	28	antiproliferative	antiproliferative	JJ
cord-312955-gs65c3fy	95	29	and	and	CC
cord-312955-gs65c3fy	95	30	immunomodulatory	immunomodulatory	JJ
cord-312955-gs65c3fy	95	31	activities	activity	NNS
cord-312955-gs65c3fy	95	32	(	(	-LRB-
cord-312955-gs65c3fy	95	33	34	34	CD
cord-312955-gs65c3fy	95	34	)	)	-RRB-
cord-312955-gs65c3fy	95	35	.	.	.
cord-312955-gs65c3fy	96	1	Further	further	JJ
cord-312955-gs65c3fy	96	2	investigations	investigation	NNS
cord-312955-gs65c3fy	96	3	into	into	IN
cord-312955-gs65c3fy	96	4	these	these	DT
cord-312955-gs65c3fy	96	5	two	two	CD
cord-312955-gs65c3fy	96	6	programs	program	NNS
cord-312955-gs65c3fy	96	7	has	have	VBZ
cord-312955-gs65c3fy	96	8	shown	show	VBN
cord-312955-gs65c3fy	96	9	that	that	IN
cord-312955-gs65c3fy	96	10	cells	cell	NNS
cord-312955-gs65c3fy	96	11	with	with	IN
cord-312955-gs65c3fy	96	12	low	low	JJ
cord-312955-gs65c3fy	96	13	receptor	receptor	NN
cord-312955-gs65c3fy	96	14	numbers	number	NNS
cord-312955-gs65c3fy	96	15	activate	activate	VBP
cord-312955-gs65c3fy	96	16	only	only	RB
cord-312955-gs65c3fy	96	17	the	the	DT
cord-312955-gs65c3fy	96	18	robust	robust	JJ
cord-312955-gs65c3fy	96	19	program	program	NN
cord-312955-gs65c3fy	96	20	,	,	,
cord-312955-gs65c3fy	96	21	and	and	CC
cord-312955-gs65c3fy	96	22	that	that	IN
cord-312955-gs65c3fy	96	23	not	not	RB
cord-312955-gs65c3fy	96	24	all	all	DT
cord-312955-gs65c3fy	96	25	cell	cell	NN
cord-312955-gs65c3fy	96	26	types	type	NNS
cord-312955-gs65c3fy	96	27	execute	execute	VBP
cord-312955-gs65c3fy	96	28	the	the	DT
cord-312955-gs65c3fy	96	29	tunable	tunable	JJ
cord-312955-gs65c3fy	96	30	program	program	NN
cord-312955-gs65c3fy	96	31	,	,	,
cord-312955-gs65c3fy	96	32	conversely	conversely	RB
cord-312955-gs65c3fy	96	33	to	to	IN
cord-312955-gs65c3fy	96	34	the	the	DT
cord-312955-gs65c3fy	96	35	robust	robust	JJ
cord-312955-gs65c3fy	96	36	program	program	NN
cord-312955-gs65c3fy	96	37	that	that	WDT
cord-312955-gs65c3fy	96	38	is	be	VBZ
cord-312955-gs65c3fy	96	39	common	common	JJ
cord-312955-gs65c3fy	96	40	to	to	IN
cord-312955-gs65c3fy	96	41	all	all	DT
cord-312955-gs65c3fy	96	42	cells	cell	NNS
cord-312955-gs65c3fy	96	43	(	(	-LRB-
cord-312955-gs65c3fy	96	44	46	46	CD
cord-312955-gs65c3fy	96	45	)	)	-RRB-
cord-312955-gs65c3fy	96	46	.	.	.
cord-312955-gs65c3fy	97	1	Tighter	tight	JJR
cord-312955-gs65c3fy	97	2	binding	bind	VBG
cord-312955-gs65c3fy	97	3	IFN	IFN	NNP
cord-312955-gs65c3fy	97	4	-	-	,
cord-312955-gs65c3fy	97	5	Is	be	VBZ
cord-312955-gs65c3fy	97	6	at	at	IN
cord-312955-gs65c3fy	97	7	higher	high	JJR
cord-312955-gs65c3fy	97	8	concentrations	concentration	NNS
cord-312955-gs65c3fy	97	9	are	be	VBP
cord-312955-gs65c3fy	97	10	essential	essential	JJ
cord-312955-gs65c3fy	97	11	for	for	IN
cord-312955-gs65c3fy	97	12	the	the	DT
cord-312955-gs65c3fy	97	13	activation	activation	NN
cord-312955-gs65c3fy	97	14	of	of	IN
cord-312955-gs65c3fy	97	15	the	the	DT
cord-312955-gs65c3fy	97	16	tunable	tunable	JJ
cord-312955-gs65c3fy	97	17	program	program	NN
cord-312955-gs65c3fy	97	18	.	.	.
cord-312955-gs65c3fy	98	1	Genes	gene	NNS
cord-312955-gs65c3fy	98	2	upregulated	upregulate	VBN
cord-312955-gs65c3fy	98	3	by	by	IN
cord-312955-gs65c3fy	98	4	the	the	DT
cord-312955-gs65c3fy	98	5	robust	robust	JJ
cord-312955-gs65c3fy	98	6	program	program	NN
cord-312955-gs65c3fy	98	7	are	be	VBP
cord-312955-gs65c3fy	98	8	mostly	mostly	RB
cord-312955-gs65c3fy	98	9	classical	classical	JJ
cord-312955-gs65c3fy	98	10	antiviral	antiviral	JJ
cord-312955-gs65c3fy	98	11	genes	gene	NNS
cord-312955-gs65c3fy	98	12	,	,	,
cord-312955-gs65c3fy	98	13	such	such	JJ
cord-312955-gs65c3fy	98	14	as	as	IN
cord-312955-gs65c3fy	98	15	MX1	MX1	NNP
cord-312955-gs65c3fy	98	16	and	and	CC
cord-312955-gs65c3fy	98	17	MX2	MX2	NNP
cord-312955-gs65c3fy	98	18	,	,	,
cord-312955-gs65c3fy	98	19	OAS1	OAS1	NNP
cord-312955-gs65c3fy	98	20	and	and	CC
cord-312955-gs65c3fy	98	21	2	2	CD
cord-312955-gs65c3fy	98	22	,	,	,
cord-312955-gs65c3fy	98	23	PKR	PKR	NNP
cord-312955-gs65c3fy	98	24	,	,	,
cord-312955-gs65c3fy	98	25	IFIT1	IFIT1	NNP
cord-312955-gs65c3fy	98	26	,	,	,
cord-312955-gs65c3fy	98	27	2	2	CD
cord-312955-gs65c3fy	98	28	and	and	CC
cord-312955-gs65c3fy	98	29	3	3	CD
cord-312955-gs65c3fy	98	30	,	,	,
cord-312955-gs65c3fy	98	31	ISG15	isg15	NN
cord-312955-gs65c3fy	98	32	,	,	,
cord-312955-gs65c3fy	98	33	and	and	CC
cord-312955-gs65c3fy	98	34	many	many	JJ
cord-312955-gs65c3fy	98	35	more	more	JJR
cord-312955-gs65c3fy	98	36	.	.	.
cord-312955-gs65c3fy	99	1	Figure	figure	NN
cord-312955-gs65c3fy	99	2	3A	3a	CD
cord-312955-gs65c3fy	100	1	According	accord	VBG
cord-312955-gs65c3fy	100	2	to	to	IN
cord-312955-gs65c3fy	100	3	STRING	string	NN
cord-312955-gs65c3fy	100	4	and	and	CC
cord-312955-gs65c3fy	100	5	GO	GO	NNP
cord-312955-gs65c3fy	100	6	analysis	analysis	NN
cord-312955-gs65c3fy	100	7	,	,	,
cord-312955-gs65c3fy	100	8	the	the	DT
cord-312955-gs65c3fy	100	9	commonly	commonly	RB
cord-312955-gs65c3fy	100	10	upregulated	upregulate	VBN
cord-312955-gs65c3fy	100	11	genes	gene	NNS
cord-312955-gs65c3fy	100	12	have	have	VBP
cord-312955-gs65c3fy	100	13	a	a	DT
cord-312955-gs65c3fy	100	14	strong	strong	JJ
cord-312955-gs65c3fy	100	15	antiviral	antiviral	JJ
cord-312955-gs65c3fy	100	16	signature	signature	NN
cord-312955-gs65c3fy	100	17	.	.	.
cord-312955-gs65c3fy	101	1	The	the	DT
cord-312955-gs65c3fy	101	2	top	top	JJ
cord-312955-gs65c3fy	101	3	GO	GO	NNP
cord-312955-gs65c3fy	101	4	terms	term	NNS
cord-312955-gs65c3fy	101	5	(	(	-LRB-
cord-312955-gs65c3fy	101	6	FDR	FDR	NNP
cord-312955-gs65c3fy	101	7	<	<	XX
cord-312955-gs65c3fy	101	8	10	10	CD
cord-312955-gs65c3fy	101	9	−25	−25	NNP
cord-312955-gs65c3fy	101	10	)	)	-RRB-
cord-312955-gs65c3fy	101	11	are	be	VBP
cord-312955-gs65c3fy	101	12	response	response	NN
cord-312955-gs65c3fy	101	13	to	to	TO
cord-312955-gs65c3fy	101	14	type	type	NN
cord-312955-gs65c3fy	101	15	I	-PRON-	PRP
cord-312955-gs65c3fy	101	16	interferon	interferon	NN
cord-312955-gs65c3fy	101	17	,	,	,
cord-312955-gs65c3fy	101	18	innate	innate	JJ
cord-312955-gs65c3fy	101	19	immune	immune	JJ
cord-312955-gs65c3fy	101	20	response	response	NN
cord-312955-gs65c3fy	101	21	,	,	,
cord-312955-gs65c3fy	101	22	response	response	NN
cord-312955-gs65c3fy	101	23	to	to	IN
cord-312955-gs65c3fy	101	24	virus	virus	NN
cord-312955-gs65c3fy	101	25	,	,	,
cord-312955-gs65c3fy	101	26	defense	defense	NN
cord-312955-gs65c3fy	101	27	response	response	NN
cord-312955-gs65c3fy	101	28	and	and	CC
cord-312955-gs65c3fy	101	29	immune	immune	JJ
cord-312955-gs65c3fy	101	30	system	system	NN
cord-312955-gs65c3fy	101	31	process	process	NN
cord-312955-gs65c3fy	101	32	.	.	.
cord-312955-gs65c3fy	102	1	It	-PRON-	PRP
cord-312955-gs65c3fy	102	2	is	be	VBZ
cord-312955-gs65c3fy	102	3	interesting	interesting	JJ
cord-312955-gs65c3fy	102	4	to	to	TO
cord-312955-gs65c3fy	102	5	note	note	VB
cord-312955-gs65c3fy	102	6	that	that	IN
cord-312955-gs65c3fy	102	7	antiviral	antiviral	JJ
cord-312955-gs65c3fy	102	8	genes	gene	NNS
cord-312955-gs65c3fy	102	9	constitute	constitute	VBP
cord-312955-gs65c3fy	102	10	most	most	JJS
cord-312955-gs65c3fy	102	11	of	of	IN
cord-312955-gs65c3fy	102	12	the	the	DT
cord-312955-gs65c3fy	102	13	upregulated	upregulate	VBN
cord-312955-gs65c3fy	102	14	genes	gene	NNS
cord-312955-gs65c3fy	102	15	common	common	JJ
cord-312955-gs65c3fy	102	16	to	to	IN
cord-312955-gs65c3fy	102	17	all	all	DT
cord-312955-gs65c3fy	102	18	4	4	CD
cord-312955-gs65c3fy	102	19	cell	cell	NN
cord-312955-gs65c3fy	102	20	lines	line	NNS
cord-312955-gs65c3fy	102	21	.	.	.
cord-312955-gs65c3fy	103	1	Antiviral	antiviral	JJ
cord-312955-gs65c3fy	103	2	genes	gene	NNS
cord-312955-gs65c3fy	103	3	are	be	VBP
cord-312955-gs65c3fy	103	4	also	also	RB
cord-312955-gs65c3fy	103	5	the	the	DT
cord-312955-gs65c3fy	103	6	majority	majority	NN
cord-312955-gs65c3fy	103	7	of	of	IN
cord-312955-gs65c3fy	103	8	upregulated	upregulated	JJ
cord-312955-gs65c3fy	103	9	genes	gene	NNS
cord-312955-gs65c3fy	103	10	in	in	IN
cord-312955-gs65c3fy	103	11	K562	k562	CD
cord-312955-gs65c3fy	103	12	and	and	CC
cord-312955-gs65c3fy	103	13	T47D	T47D	NNP
cord-312955-gs65c3fy	103	14	cells	cell	NNS
cord-312955-gs65c3fy	103	15	.	.	.
cord-312955-gs65c3fy	104	1	Conversely	conversely	RB
cord-312955-gs65c3fy	104	2	,	,	,
cord-312955-gs65c3fy	104	3	OVCAR3	OVCAR3	NNP
cord-312955-gs65c3fy	104	4	and	and	CC
cord-312955-gs65c3fy	104	5	HeLa	HeLa	NNP
cord-312955-gs65c3fy	104	6	cells	cell	NNS
cord-312955-gs65c3fy	104	7	have	have	VBP
cord-312955-gs65c3fy	104	8	many	many	JJ
cord-312955-gs65c3fy	104	9	unique	unique	JJ
cord-312955-gs65c3fy	104	10	upregulated	upregulate	VBN
cord-312955-gs65c3fy	104	11	genes	gene	NNS
cord-312955-gs65c3fy	104	12	,	,	,
cord-312955-gs65c3fy	104	13	many	many	JJ
cord-312955-gs65c3fy	104	14	of	of	IN
cord-312955-gs65c3fy	104	15	them	-PRON-	PRP
cord-312955-gs65c3fy	104	16	related	relate	VBN
cord-312955-gs65c3fy	104	17	to	to	IN
cord-312955-gs65c3fy	104	18	immunomodulatory	immunomodulatory	JJ
cord-312955-gs65c3fy	104	19	functions	function	NNS
cord-312955-gs65c3fy	104	20	,	,	,
cord-312955-gs65c3fy	104	21	cell	cell	NN
cord-312955-gs65c3fy	104	22	cycle	cycle	NN
cord-312955-gs65c3fy	104	23	,	,	,
cord-312955-gs65c3fy	104	24	apoptosys	apoptosys	NN
cord-312955-gs65c3fy	104	25	and	and	CC
cord-312955-gs65c3fy	104	26	more	more	JJR
cord-312955-gs65c3fy	104	27	.	.	.
cord-312955-gs65c3fy	105	1	IFN	IFN	NNP
cord-312955-gs65c3fy	105	2	-	-	HYPH
cord-312955-gs65c3fy	105	3	I.	I.	NNP
cord-312955-gs65c3fy	106	1	The	the	DT
cord-312955-gs65c3fy	106	2	diagram	diagram	NN
cord-312955-gs65c3fy	106	3	shows	show	VBZ
cord-312955-gs65c3fy	106	4	that	that	IN
cord-312955-gs65c3fy	106	5	53	53	CD
cord-312955-gs65c3fy	106	6	genes	gene	NNS
cord-312955-gs65c3fy	106	7	are	be	VBP
cord-312955-gs65c3fy	106	8	commonly	commonly	RB
cord-312955-gs65c3fy	106	9	upregulated	upregulate	VBN
cord-312955-gs65c3fy	106	10	by	by	IN
cord-312955-gs65c3fy	106	11	all	all	DT
cord-312955-gs65c3fy	106	12	4	4	CD
cord-312955-gs65c3fy	106	13	cell	cell	NN
cord-312955-gs65c3fy	106	14	-	-	HYPH
cord-312955-gs65c3fy	106	15	lines	line	NNS
cord-312955-gs65c3fy	106	16	.	.	.
cord-312955-gs65c3fy	107	1	Figure	figure	NN
cord-312955-gs65c3fy	107	2	3B	3b	CD
cord-312955-gs65c3fy	107	3	shows	show	VBZ
cord-312955-gs65c3fy	107	4	STRING	string	NN
cord-312955-gs65c3fy	107	5	protein	protein	NN
cord-312955-gs65c3fy	107	6	interaction	interaction	NN
cord-312955-gs65c3fy	107	7	analysis	analysis	NN
cord-312955-gs65c3fy	107	8	of	of	IN
cord-312955-gs65c3fy	107	9	these	these	DT
cord-312955-gs65c3fy	107	10	common	common	JJ
cord-312955-gs65c3fy	107	11	genes	gene	NNS
cord-312955-gs65c3fy	107	12	.	.	.
cord-312955-gs65c3fy	108	1	Clearly	clearly	RB
cord-312955-gs65c3fy	108	2	,	,	,
cord-312955-gs65c3fy	108	3	these	these	DT
cord-312955-gs65c3fy	108	4	form	form	VBP
cord-312955-gs65c3fy	108	5	a	a	DT
cord-312955-gs65c3fy	108	6	tightly	tightly	RB
cord-312955-gs65c3fy	108	7	interacting	interact	VBG
cord-312955-gs65c3fy	108	8	mesh	mesh	NN
cord-312955-gs65c3fy	108	9	of	of	IN
cord-312955-gs65c3fy	108	10	gene	gene	NN
cord-312955-gs65c3fy	108	11	products	product	NNS
cord-312955-gs65c3fy	108	12	.	.	.
cord-312955-gs65c3fy	109	1	Gene	Gene	NNP
cord-312955-gs65c3fy	109	2	Ontology	Ontology	NNP
cord-312955-gs65c3fy	109	3	analysis	analysis	NN
cord-312955-gs65c3fy	109	4	shows	show	VBZ
cord-312955-gs65c3fy	109	5	these	these	DT
cord-312955-gs65c3fy	109	6	genes	gene	NNS
cord-312955-gs65c3fy	109	7	to	to	TO
cord-312955-gs65c3fy	109	8	have	have	VB
cord-312955-gs65c3fy	109	9	an	an	DT
cord-312955-gs65c3fy	109	10	extremely	extremely	RB
cord-312955-gs65c3fy	109	11	high	high	JJ
cord-312955-gs65c3fy	109	12	signature	signature	NN
cord-312955-gs65c3fy	109	13	for	for	IN
cord-312955-gs65c3fy	109	14	antiviral	antiviral	JJ
cord-312955-gs65c3fy	109	15	activity	activity	NN
cord-312955-gs65c3fy	109	16	and	and	CC
cord-312955-gs65c3fy	109	17	IFN	IFN	NNP
cord-312955-gs65c3fy	109	18	-	-	HYPH
cord-312955-gs65c3fy	109	19	I	-PRON-	PRP
cord-312955-gs65c3fy	109	20	activation	activation	NN
cord-312955-gs65c3fy	109	21	.	.	.
cord-312955-gs65c3fy	110	1	Promoter	promoter	NN
cord-312955-gs65c3fy	110	2	analysis	analysis	NN
cord-312955-gs65c3fy	110	3	of	of	IN
cord-312955-gs65c3fy	110	4	common	common	JJ
cord-312955-gs65c3fy	110	5	ISGs	ISGs	NNPS
cord-312955-gs65c3fy	110	6	has	have	VBZ
cord-312955-gs65c3fy	110	7	shown	show	VBN
cord-312955-gs65c3fy	110	8	them	-PRON-	PRP
cord-312955-gs65c3fy	110	9	to	to	TO
cord-312955-gs65c3fy	110	10	be	be	VB
cord-312955-gs65c3fy	110	11	driven	drive	VBN
cord-312955-gs65c3fy	110	12	by	by	IN
cord-312955-gs65c3fy	110	13	the	the	DT
cord-312955-gs65c3fy	110	14	classical	classical	JJ
cord-312955-gs65c3fy	110	15	ISRE	ISRE	NNP
cord-312955-gs65c3fy	110	16	promoter	promoter	NN
cord-312955-gs65c3fy	110	17	sequence	sequence	NN
cord-312955-gs65c3fy	110	18	(	(	-LRB-
cord-312955-gs65c3fy	110	19	45	45	CD
cord-312955-gs65c3fy	110	20	)	)	-RRB-
cord-312955-gs65c3fy	110	21	.	.	.
cord-312955-gs65c3fy	111	1	Conversely	conversely	RB
cord-312955-gs65c3fy	111	2	,	,	,
cord-312955-gs65c3fy	111	3	for	for	IN
cord-312955-gs65c3fy	111	4	tunable	tunable	JJ
cord-312955-gs65c3fy	111	5	genes	gene	NNS
cord-312955-gs65c3fy	111	6	no	no	DT
cord-312955-gs65c3fy	111	7	clear	clear	JJ
cord-312955-gs65c3fy	111	8	promoter	promoter	NN
cord-312955-gs65c3fy	111	9	sequence	sequence	NN
cord-312955-gs65c3fy	111	10	was	be	VBD
cord-312955-gs65c3fy	111	11	identified	identify	VBN
cord-312955-gs65c3fy	111	12	.	.	.
cord-312955-gs65c3fy	112	1	The	the	DT
cord-312955-gs65c3fy	112	2	exact	exact	JJ
cord-312955-gs65c3fy	112	3	mechanism	mechanism	NN
cord-312955-gs65c3fy	112	4	of	of	IN
cord-312955-gs65c3fy	112	5	how	how	WRB
cord-312955-gs65c3fy	112	6	tunable	tunable	JJ
cord-312955-gs65c3fy	112	7	genes	gene	NNS
cord-312955-gs65c3fy	112	8	are	be	VBP
cord-312955-gs65c3fy	112	9	upregulated	upregulate	VBN
cord-312955-gs65c3fy	112	10	by	by	IN
cord-312955-gs65c3fy	112	11	IFN	IFN	NNP
cord-312955-gs65c3fy	112	12	-	-	HYPH
cord-312955-gs65c3fy	112	13	I	-PRON-	PRP
cord-312955-gs65c3fy	112	14	is	be	VBZ
cord-312955-gs65c3fy	112	15	thus	thus	RB
cord-312955-gs65c3fy	112	16	not	not	RB
cord-312955-gs65c3fy	112	17	yet	yet	RB
cord-312955-gs65c3fy	112	18	fully	fully	RB
cord-312955-gs65c3fy	112	19	understood	understand	VBN
cord-312955-gs65c3fy	112	20	.	.	.
cord-312955-gs65c3fy	113	1	From	from	IN
cord-312955-gs65c3fy	113	2	an	an	DT
cord-312955-gs65c3fy	113	3	immunological	immunological	JJ
cord-312955-gs65c3fy	113	4	point	point	NN
cord-312955-gs65c3fy	113	5	of	of	IN
cord-312955-gs65c3fy	113	6	view	view	NN
cord-312955-gs65c3fy	113	7	,	,	,
cord-312955-gs65c3fy	113	8	IFN	IFN	NNP
cord-312955-gs65c3fy	113	9	-	-	:
cord-312955-gs65c3fy	113	10	Is	be	VBZ
cord-312955-gs65c3fy	113	11	have	have	VB
cord-312955-gs65c3fy	113	12	three	three	CD
cord-312955-gs65c3fy	113	13	major	major	JJ
cord-312955-gs65c3fy	113	14	functions	function	NNS
cord-312955-gs65c3fy	113	15	:	:	:
cord-312955-gs65c3fy	113	16	1	1	CD
cord-312955-gs65c3fy	113	17	.	.	.
cord-312955-gs65c3fy	114	1	To	to	TO
cord-312955-gs65c3fy	114	2	activate	activate	VB
cord-312955-gs65c3fy	114	3	an	an	DT
cord-312955-gs65c3fy	114	4	antiviral	antiviral	JJ
cord-312955-gs65c3fy	114	5	state	state	NN
cord-312955-gs65c3fy	114	6	in	in	IN
cord-312955-gs65c3fy	114	7	infected	infected	JJ
cord-312955-gs65c3fy	114	8	and	and	CC
cord-312955-gs65c3fy	114	9	neighboring	neighboring	NN
cord-312955-gs65c3fy	114	10	cells	cell	NNS
cord-312955-gs65c3fy	114	11	that	that	WDT
cord-312955-gs65c3fy	114	12	limits	limit	VBZ
cord-312955-gs65c3fy	114	13	spread	spread	NN
cord-312955-gs65c3fy	114	14	of	of	IN
cord-312955-gs65c3fy	114	15	infection	infection	NN
cord-312955-gs65c3fy	114	16	.	.	.
cord-312955-gs65c3fy	115	1	2	2	LS
cord-312955-gs65c3fy	115	2	.	.	.
cord-312955-gs65c3fy	116	1	Modulate	modulate	VB
cord-312955-gs65c3fy	116	2	innate	innate	JJ
cord-312955-gs65c3fy	116	3	immune	immune	JJ
cord-312955-gs65c3fy	116	4	responses	response	NNS
cord-312955-gs65c3fy	116	5	,	,	,
cord-312955-gs65c3fy	116	6	including	include	VBG
cord-312955-gs65c3fy	116	7	antigen	antigen	NN
cord-312955-gs65c3fy	116	8	presentation	presentation	NN
cord-312955-gs65c3fy	116	9	and	and	CC
cord-312955-gs65c3fy	116	10	natural	natural	JJ
cord-312955-gs65c3fy	116	11	killer	killer	NN
cord-312955-gs65c3fy	116	12	cell	cell	NN
cord-312955-gs65c3fy	116	13	functions	function	NNS
cord-312955-gs65c3fy	116	14	while	while	IN
cord-312955-gs65c3fy	116	15	restraining	restrain	VBG
cord-312955-gs65c3fy	116	16	pro	pro	JJ
cord-312955-gs65c3fy	116	17	-	-	JJ
cord-312955-gs65c3fy	116	18	inflammatory	inflammatory	JJ
cord-312955-gs65c3fy	116	19	pathways	pathway	NNS
cord-312955-gs65c3fy	116	20	.	.	.
cord-312955-gs65c3fy	117	1	3	3	LS
cord-312955-gs65c3fy	117	2	.	.	.
cord-312955-gs65c3fy	118	1	activating	activate	VBG
cord-312955-gs65c3fy	118	2	the	the	DT
cord-312955-gs65c3fy	118	3	adaptive	adaptive	JJ
cord-312955-gs65c3fy	118	4	immune	immune	JJ
cord-312955-gs65c3fy	118	5	system	system	NN
cord-312955-gs65c3fy	118	6	for	for	IN
cord-312955-gs65c3fy	118	7	the	the	DT
cord-312955-gs65c3fy	118	8	development	development	NN
cord-312955-gs65c3fy	118	9	of	of	IN
cord-312955-gs65c3fy	118	10	high	high	JJ
cord-312955-gs65c3fy	118	11	-	-	HYPH
cord-312955-gs65c3fy	118	12	affinity	affinity	NN
cord-312955-gs65c3fy	118	13	antigen	antigen	NN
cord-312955-gs65c3fy	118	14	-	-	HYPH
cord-312955-gs65c3fy	118	15	specific	specific	JJ
cord-312955-gs65c3fy	118	16	T	t	NN
cord-312955-gs65c3fy	118	17	and	and	CC
cord-312955-gs65c3fy	118	18	B	b	NN
cord-312955-gs65c3fy	118	19	cell	cell	NN
cord-312955-gs65c3fy	118	20	responses	response	NNS
cord-312955-gs65c3fy	118	21	(	(	-LRB-
cord-312955-gs65c3fy	118	22	47	47	CD
cord-312955-gs65c3fy	118	23	)	)	-RRB-
cord-312955-gs65c3fy	118	24	.	.	.
cord-312955-gs65c3fy	119	1	As	as	IN
cord-312955-gs65c3fy	119	2	IFN	IFN	NNP
cord-312955-gs65c3fy	119	3	-	-	:
cord-312955-gs65c3fy	119	4	Is	be	VBZ
cord-312955-gs65c3fy	119	5	are	be	VBP
cord-312955-gs65c3fy	119	6	highly	highly	RB
cord-312955-gs65c3fy	119	7	active	active	JJ
cord-312955-gs65c3fy	119	8	molecules	molecule	NNS
cord-312955-gs65c3fy	119	9	,	,	,
cord-312955-gs65c3fy	119	10	their	-PRON-	PRP$
cord-312955-gs65c3fy	119	11	expression	expression	NN
cord-312955-gs65c3fy	119	12	and	and	CC
cord-312955-gs65c3fy	119	13	signaling	signal	VBG
cord-312955-gs65c3fy	119	14	potency	potency	NN
cord-312955-gs65c3fy	119	15	is	be	VBZ
cord-312955-gs65c3fy	119	16	highly	highly	RB
cord-312955-gs65c3fy	119	17	regulated	regulate	VBN
cord-312955-gs65c3fy	119	18	.	.	.
cord-312955-gs65c3fy	120	1	Opposing	oppose	VBG
cord-312955-gs65c3fy	120	2	augmenting	augment	VBG
cord-312955-gs65c3fy	120	3	and	and	CC
cord-312955-gs65c3fy	120	4	suppressive	suppressive	JJ
cord-312955-gs65c3fy	120	5	signals	signal	NNS
cord-312955-gs65c3fy	120	6	are	be	VBP
cord-312955-gs65c3fy	120	7	induced	induce	VBN
cord-312955-gs65c3fy	120	8	by	by	IN
cord-312955-gs65c3fy	120	9	host	host	NN
cord-312955-gs65c3fy	120	10	factors	factor	NNS
cord-312955-gs65c3fy	120	11	.	.	.
cord-312955-gs65c3fy	121	1	Suppressive	suppressive	JJ
cord-312955-gs65c3fy	121	2	pathways	pathway	NNS
cord-312955-gs65c3fy	121	3	include	include	VBP
cord-312955-gs65c3fy	121	4	IFN	IFN	NNP
cord-312955-gs65c3fy	121	5	-	-	HYPH
cord-312955-gs65c3fy	121	6	I	I	NNP
cord-312955-gs65c3fy	121	7	activation	activation	NN
cord-312955-gs65c3fy	121	8	of	of	IN
cord-312955-gs65c3fy	121	9	USP18	USP18	NNP
cord-312955-gs65c3fy	121	10	,	,	,
cord-312955-gs65c3fy	121	11	an	an	DT
cord-312955-gs65c3fy	121	12	ISG	ISG	NNP
cord-312955-gs65c3fy	121	13	that	that	WDT
cord-312955-gs65c3fy	121	14	suppresses	suppress	VBZ
cord-312955-gs65c3fy	121	15	signal	signal	NN
cord-312955-gs65c3fy	121	16	transduction	transduction	NN
cord-312955-gs65c3fy	121	17	by	by	IN
cord-312955-gs65c3fy	121	18	reducing	reduce	VBG
cord-312955-gs65c3fy	121	19	the	the	DT
cord-312955-gs65c3fy	121	20	ability	ability	NN
cord-312955-gs65c3fy	121	21	of	of	IN
cord-312955-gs65c3fy	121	22	IFN	IFN	NNP
cord-312955-gs65c3fy	121	23	-	-	,
cord-312955-gs65c3fy	121	24	Is	be	VBZ
cord-312955-gs65c3fy	121	25	to	to	TO
cord-312955-gs65c3fy	121	26	form	form	VB
cord-312955-gs65c3fy	121	27	an	an	DT
cord-312955-gs65c3fy	121	28	active	active	JJ
cord-312955-gs65c3fy	121	29	receptor	receptor	NN
cord-312955-gs65c3fy	121	30	complex	complex	NN
cord-312955-gs65c3fy	121	31	(	(	-LRB-
cord-312955-gs65c3fy	121	32	38	38	CD
cord-312955-gs65c3fy	121	33	,	,	,
cord-312955-gs65c3fy	121	34	48	48	CD
cord-312955-gs65c3fy	121	35	)	)	-RRB-
cord-312955-gs65c3fy	121	36	.	.	.
cord-312955-gs65c3fy	122	1	A	a	DT
cord-312955-gs65c3fy	122	2	second	second	JJ
cord-312955-gs65c3fy	122	3	inhibitory	inhibitory	JJ
cord-312955-gs65c3fy	122	4	mechanism	mechanism	NN
cord-312955-gs65c3fy	122	5	is	be	VBZ
cord-312955-gs65c3fy	122	6	the	the	DT
cord-312955-gs65c3fy	122	7	induction	induction	NN
cord-312955-gs65c3fy	122	8	of	of	IN
cord-312955-gs65c3fy	122	9	SOCS1	SOCS1	NNP
cord-312955-gs65c3fy	122	10	and	and	CC
cord-312955-gs65c3fy	122	11	SOCS3	SOCS3	NNP
cord-312955-gs65c3fy	122	12	,	,	,
cord-312955-gs65c3fy	122	13	which	which	WDT
cord-312955-gs65c3fy	122	14	KIR	KIR	NNP
cord-312955-gs65c3fy	122	15	domain	domain	NN
cord-312955-gs65c3fy	122	16	block	block	VB
cord-312955-gs65c3fy	122	17	the	the	DT
cord-312955-gs65c3fy	122	18	substrate	substrate	NN
cord-312955-gs65c3fy	122	19	binding	bind	VBG
cord-312955-gs65c3fy	122	20	groove	groove	NN
cord-312955-gs65c3fy	122	21	on	on	IN
cord-312955-gs65c3fy	122	22	JAK	JAK	NNP
cord-312955-gs65c3fy	122	23	,	,	,
cord-312955-gs65c3fy	122	24	thereby	thereby	RB
cord-312955-gs65c3fy	122	25	inhibiting	inhibit	VBG
cord-312955-gs65c3fy	122	26	STAT	stat	NN
cord-312955-gs65c3fy	122	27	phosphorylation	phosphorylation	NN
cord-312955-gs65c3fy	122	28	(	(	-LRB-
cord-312955-gs65c3fy	122	29	49	49	CD
cord-312955-gs65c3fy	122	30	)	)	-RRB-
cord-312955-gs65c3fy	122	31	.	.	.
cord-312955-gs65c3fy	123	1	A	a	DT
cord-312955-gs65c3fy	123	2	third	third	JJ
cord-312955-gs65c3fy	123	3	mechanism	mechanism	NN
cord-312955-gs65c3fy	123	4	is	be	VBZ
cord-312955-gs65c3fy	123	5	by	by	IN
cord-312955-gs65c3fy	123	6	rapid	rapid	JJ
cord-312955-gs65c3fy	123	7	endocytosis	endocytosis	NN
cord-312955-gs65c3fy	123	8	and	and	CC
cord-312955-gs65c3fy	123	9	subsequent	subsequent	JJ
cord-312955-gs65c3fy	123	10	lysosomal	lysosomal	JJ
cord-312955-gs65c3fy	123	11	degradation	degradation	NN
cord-312955-gs65c3fy	123	12	of	of	IN
cord-312955-gs65c3fy	123	13	activated	activate	VBN
cord-312955-gs65c3fy	123	14	IFNAR	IFNAR	NNP
cord-312955-gs65c3fy	123	15	complexes	complex	NNS
cord-312955-gs65c3fy	123	16	(	(	-LRB-
cord-312955-gs65c3fy	123	17	50	50	CD
cord-312955-gs65c3fy	123	18	,	,	,
cord-312955-gs65c3fy	123	19	51	51	CD
cord-312955-gs65c3fy	123	20	)	)	-RRB-
cord-312955-gs65c3fy	123	21	resulting	result	VBG
cord-312955-gs65c3fy	123	22	in	in	IN
cord-312955-gs65c3fy	123	23	reduced	reduce	VBN
cord-312955-gs65c3fy	123	24	receptor	receptor	NN
cord-312955-gs65c3fy	123	25	numbers	number	NNS
cord-312955-gs65c3fy	123	26	(	(	-LRB-
cord-312955-gs65c3fy	123	27	Figure	figure	NN
cord-312955-gs65c3fy	123	28	1	1	CD
cord-312955-gs65c3fy	123	29	)	)	-RRB-
cord-312955-gs65c3fy	123	30	.	.	.
cord-312955-gs65c3fy	124	1	It	-PRON-	PRP
cord-312955-gs65c3fy	124	2	has	have	VBZ
cord-312955-gs65c3fy	124	3	been	be	VBN
cord-312955-gs65c3fy	124	4	demonstrated	demonstrate	VBN
cord-312955-gs65c3fy	124	5	that	that	IN
cord-312955-gs65c3fy	124	6	a	a	DT
cord-312955-gs65c3fy	124	7	mutant	mutant	NN
cord-312955-gs65c3fy	124	8	in	in	IN
cord-312955-gs65c3fy	124	9	IFNAR1	ifnar1	NN
cord-312955-gs65c3fy	125	1	(	(	-LRB-
cord-312955-gs65c3fy	125	2	S535A	s535a	NN
cord-312955-gs65c3fy	125	3	and	and	CC
cord-312955-gs65c3fy	125	4	S526A	S526A	NNPS
cord-312955-gs65c3fy	125	5	in	in	IN
cord-312955-gs65c3fy	125	6	human	human	NN
cord-312955-gs65c3fy	125	7	and	and	CC
cord-312955-gs65c3fy	125	8	mouse	mouse	NN
cord-312955-gs65c3fy	125	9	respectively	respectively	RB
cord-312955-gs65c3fy	125	10	)	)	-RRB-
cord-312955-gs65c3fy	125	11	,	,	,
cord-312955-gs65c3fy	125	12	which	which	WDT
cord-312955-gs65c3fy	125	13	fails	fail	VBZ
cord-312955-gs65c3fy	125	14	in	in	IN
cord-312955-gs65c3fy	125	15	IFNAR1	ifnar1	NN
cord-312955-gs65c3fy	125	16	endocytosis	endocytosis	NN
cord-312955-gs65c3fy	125	17	through	through	IN
cord-312955-gs65c3fy	125	18	blocking	block	VBG
cord-312955-gs65c3fy	125	19	its	-PRON-	PRP$
cord-312955-gs65c3fy	125	20	ubiquitination	ubiquitination	NN
cord-312955-gs65c3fy	125	21	result	result	NN
cord-312955-gs65c3fy	125	22	in	in	IN
cord-312955-gs65c3fy	125	23	high	high	JJ
cord-312955-gs65c3fy	125	24	incidence	incidence	NN
cord-312955-gs65c3fy	125	25	of	of	IN
cord-312955-gs65c3fy	125	26	inflammation	inflammation	NN
cord-312955-gs65c3fy	125	27	(	(	-LRB-
cord-312955-gs65c3fy	125	28	51	51	CD
cord-312955-gs65c3fy	125	29	,	,	,
cord-312955-gs65c3fy	125	30	52	52	CD
cord-312955-gs65c3fy	125	31	)	)	-RRB-
cord-312955-gs65c3fy	125	32	.	.	.
cord-312955-gs65c3fy	126	1	At	at	IN
cord-312955-gs65c3fy	126	2	the	the	DT
cord-312955-gs65c3fy	126	3	transcriptional	transcriptional	JJ
cord-312955-gs65c3fy	126	4	level	level	NN
cord-312955-gs65c3fy	126	5	,	,	,
cord-312955-gs65c3fy	126	6	IFN	IFN	NNP
cord-312955-gs65c3fy	126	7	-	-	HYPH
cord-312955-gs65c3fy	126	8	I	-PRON-	PRP
cord-312955-gs65c3fy	126	9	response	response	NN
cord-312955-gs65c3fy	126	10	can	can	MD
cord-312955-gs65c3fy	126	11	also	also	RB
cord-312955-gs65c3fy	126	12	be	be	VB
cord-312955-gs65c3fy	126	13	regulated	regulate	VBN
cord-312955-gs65c3fy	126	14	by	by	IN
cord-312955-gs65c3fy	126	15	miR-155	miR-155	NNP
cord-312955-gs65c3fy	126	16	,	,	,
cord-312955-gs65c3fy	126	17	which	which	WDT
cord-312955-gs65c3fy	126	18	is	be	VBZ
cord-312955-gs65c3fy	126	19	highly	highly	RB
cord-312955-gs65c3fy	126	20	induced	induce	VBN
cord-312955-gs65c3fy	126	21	by	by	IN
cord-312955-gs65c3fy	126	22	pattern	pattern	NN
cord-312955-gs65c3fy	126	23	recognition	recognition	NN
cord-312955-gs65c3fy	126	24	receptors	receptor	NNS
cord-312955-gs65c3fy	126	25	and	and	CC
cord-312955-gs65c3fy	126	26	inflammatory	inflammatory	JJ
cord-312955-gs65c3fy	126	27	signaling	signaling	NN
cord-312955-gs65c3fy	126	28	,	,	,
cord-312955-gs65c3fy	126	29	and	and	CC
cord-312955-gs65c3fy	126	30	suppresses	suppress	VBZ
cord-312955-gs65c3fy	126	31	the	the	DT
cord-312955-gs65c3fy	126	32	expression	expression	NN
cord-312955-gs65c3fy	126	33	of	of	IN
cord-312955-gs65c3fy	126	34	over	over	IN
cord-312955-gs65c3fy	126	35	100	100	CD
cord-312955-gs65c3fy	126	36	genes	gene	NNS
cord-312955-gs65c3fy	126	37	.	.	.
cord-312955-gs65c3fy	127	1	Between	between	IN
cord-312955-gs65c3fy	127	2	them	-PRON-	PRP
cord-312955-gs65c3fy	127	3	genes	gene	NNS
cord-312955-gs65c3fy	127	4	related	relate	VBN
cord-312955-gs65c3fy	127	5	to	to	IN
cord-312955-gs65c3fy	127	6	the	the	DT
cord-312955-gs65c3fy	127	7	interferon	interferon	NN
cord-312955-gs65c3fy	127	8	pathway	pathway	NN
cord-312955-gs65c3fy	127	9	.	.	.
cord-312955-gs65c3fy	128	1	It	-PRON-	PRP
cord-312955-gs65c3fy	128	2	was	be	VBD
cord-312955-gs65c3fy	128	3	shown	show	VBN
cord-312955-gs65c3fy	128	4	that	that	IN
cord-312955-gs65c3fy	128	5	miR-155-deficient	mir-155-deficient	JJ
cord-312955-gs65c3fy	128	6	CD8(+	cd8(+	CD
cord-312955-gs65c3fy	128	7	)	)	-RRB-
cord-312955-gs65c3fy	129	1	T	t	NN
cord-312955-gs65c3fy	129	2	cells	cell	NNS
cord-312955-gs65c3fy	129	3	had	have	VBD
cord-312955-gs65c3fy	129	4	enhanced	enhance	VBN
cord-312955-gs65c3fy	129	5	type	type	NN
cord-312955-gs65c3fy	129	6	I	-PRON-	PRP
cord-312955-gs65c3fy	129	7	interferon	interferon	NN
cord-312955-gs65c3fy	129	8	signaling	signal	VBG
cord-312955-gs65c3fy	129	9	and	and	CC
cord-312955-gs65c3fy	129	10	were	be	VBD
cord-312955-gs65c3fy	129	11	more	more	RBR
cord-312955-gs65c3fy	129	12	susceptible	susceptible	JJ
cord-312955-gs65c3fy	129	13	to	to	IN
cord-312955-gs65c3fy	129	14	interferon	interferon	NN
cord-312955-gs65c3fy	129	15	's	's	POS
cord-312955-gs65c3fy	129	16	antiproliferative	antiproliferative	JJ
cord-312955-gs65c3fy	129	17	effect	effect	NN
cord-312955-gs65c3fy	129	18	(	(	-LRB-
cord-312955-gs65c3fy	129	19	53	53	CD
cord-312955-gs65c3fy	129	20	)	)	-RRB-
cord-312955-gs65c3fy	129	21	.	.	.
cord-312955-gs65c3fy	130	1	High	high	JJ
cord-312955-gs65c3fy	130	2	basal	basal	NN
cord-312955-gs65c3fy	130	3	IFN	IFN	NNP
cord-312955-gs65c3fy	130	4	-	-	HYPH
cord-312955-gs65c3fy	130	5	I	-PRON-	PRP
cord-312955-gs65c3fy	130	6	levels	level	NNS
cord-312955-gs65c3fy	130	7	are	be	VBP
cord-312955-gs65c3fy	130	8	implicated	implicate	VBN
cord-312955-gs65c3fy	130	9	in	in	IN
cord-312955-gs65c3fy	130	10	various	various	JJ
cord-312955-gs65c3fy	130	11	immunological	immunological	JJ
cord-312955-gs65c3fy	130	12	diseases	disease	NNS
cord-312955-gs65c3fy	130	13	,	,	,
cord-312955-gs65c3fy	130	14	such	such	JJ
cord-312955-gs65c3fy	130	15	as	as	IN
cord-312955-gs65c3fy	130	16	systemic	systemic	JJ
cord-312955-gs65c3fy	130	17	lupus	lupus	NN
cord-312955-gs65c3fy	130	18	erythematosus	erythematosus	NN
cord-312955-gs65c3fy	130	19	and	and	CC
cord-312955-gs65c3fy	130	20	more	more	JJR
cord-312955-gs65c3fy	130	21	(	(	-LRB-
cord-312955-gs65c3fy	130	22	18	18	CD
cord-312955-gs65c3fy	130	23	,	,	,
cord-312955-gs65c3fy	130	24	54	54	CD
cord-312955-gs65c3fy	130	25	,	,	,
cord-312955-gs65c3fy	130	26	55	55	CD
cord-312955-gs65c3fy	130	27	)	)	-RRB-
cord-312955-gs65c3fy	130	28	.	.	.
cord-312955-gs65c3fy	131	1	However	however	RB
cord-312955-gs65c3fy	131	2	,	,	,
cord-312955-gs65c3fy	131	3	IFN	IFN	NNP
cord-312955-gs65c3fy	131	4	-	-	HYPH
cord-312955-gs65c3fy	131	5	I	-PRON-	PRP
cord-312955-gs65c3fy	131	6	has	have	VBZ
cord-312955-gs65c3fy	131	7	also	also	RB
cord-312955-gs65c3fy	131	8	anti	anti	JJ
cord-312955-gs65c3fy	131	9	-	-	JJ
cord-312955-gs65c3fy	131	10	inflammatory	inflammatory	JJ
cord-312955-gs65c3fy	131	11	effects	effect	NNS
cord-312955-gs65c3fy	131	12	,	,	,
cord-312955-gs65c3fy	131	13	as	as	IN
cord-312955-gs65c3fy	131	14	best	well	RBS
cord-312955-gs65c3fy	131	15	demonstrated	demonstrate	VBN
cord-312955-gs65c3fy	131	16	by	by	IN
cord-312955-gs65c3fy	131	17	their	-PRON-	PRP$
cord-312955-gs65c3fy	131	18	ability	ability	NN
cord-312955-gs65c3fy	131	19	to	to	TO
cord-312955-gs65c3fy	131	20	suppress	suppress	VB
cord-312955-gs65c3fy	131	21	multiple	multiple	JJ
cord-312955-gs65c3fy	131	22	-	-	HYPH
cord-312955-gs65c3fy	131	23	sclerosis	sclerosis	NN
cord-312955-gs65c3fy	131	24	(	(	-LRB-
cord-312955-gs65c3fy	131	25	56	56	CD
cord-312955-gs65c3fy	131	26	)	)	-RRB-
cord-312955-gs65c3fy	131	27	.	.	.
cord-312955-gs65c3fy	132	1	It	-PRON-	PRP
cord-312955-gs65c3fy	132	2	is	be	VBZ
cord-312955-gs65c3fy	132	3	important	important	JJ
cord-312955-gs65c3fy	132	4	to	to	TO
cord-312955-gs65c3fy	132	5	note	note	VB
cord-312955-gs65c3fy	132	6	that	that	IN
cord-312955-gs65c3fy	132	7	beneficial	beneficial	JJ
cord-312955-gs65c3fy	132	8	results	result	NNS
cord-312955-gs65c3fy	132	9	in	in	IN
cord-312955-gs65c3fy	132	10	treating	treat	VBG
cord-312955-gs65c3fy	132	11	multiplesclerosis	multiplesclerosis	NN
cord-312955-gs65c3fy	132	12	were	be	VBD
cord-312955-gs65c3fy	132	13	observed	observe	VBN
cord-312955-gs65c3fy	132	14	only	only	RB
cord-312955-gs65c3fy	132	15	for	for	IN
cord-312955-gs65c3fy	132	16	IFNb	IFNb	NNS
cord-312955-gs65c3fy	132	17	but	but	CC
cord-312955-gs65c3fy	132	18	not	not	RB
cord-312955-gs65c3fy	132	19	for	for	IN
cord-312955-gs65c3fy	132	20	IFNa	IFNa	NNS
cord-312955-gs65c3fy	132	21	treatment	treatment	NN
cord-312955-gs65c3fy	132	22	(	(	-LRB-
cord-312955-gs65c3fy	132	23	56	56	CD
cord-312955-gs65c3fy	132	24	)	)	-RRB-
cord-312955-gs65c3fy	132	25	.	.	.
cord-312955-gs65c3fy	133	1	To	to	TO
cord-312955-gs65c3fy	133	2	see	see	VB
cord-312955-gs65c3fy	133	3	whether	whether	IN
cord-312955-gs65c3fy	133	4	this	this	DT
cord-312955-gs65c3fy	133	5	relates	relate	VBZ
cord-312955-gs65c3fy	133	6	to	to	IN
cord-312955-gs65c3fy	133	7	the	the	DT
cord-312955-gs65c3fy	133	8	higher	high	JJR
cord-312955-gs65c3fy	133	9	receptor	receptor	NN
cord-312955-gs65c3fy	133	10	binding	bind	VBG
cord-312955-gs65c3fy	133	11	affinity	affinity	NN
cord-312955-gs65c3fy	133	12	of	of	IN
cord-312955-gs65c3fy	133	13	IFNb	IFNb	NNS
cord-312955-gs65c3fy	133	14	,	,	,
cord-312955-gs65c3fy	133	15	we	-PRON-	PRP
cord-312955-gs65c3fy	133	16	established	establish	VBD
cord-312955-gs65c3fy	133	17	a	a	DT
cord-312955-gs65c3fy	133	18	transgenic	transgenic	JJ
cord-312955-gs65c3fy	133	19	mouse	mouse	NN
cord-312955-gs65c3fy	133	20	harboring	harbor	VBG
cord-312955-gs65c3fy	133	21	the	the	DT
cord-312955-gs65c3fy	133	22	human	human	JJ
cord-312955-gs65c3fy	133	23	interferon	interferon	NN
cord-312955-gs65c3fy	133	24	-	-	HYPH
cord-312955-gs65c3fy	133	25	receptors	receptor	NNS
cord-312955-gs65c3fy	133	26	extracellular	extracellular	JJ
cord-312955-gs65c3fy	133	27	domains	domain	NNS
cord-312955-gs65c3fy	133	28	fussed	fuss	VBD
cord-312955-gs65c3fy	133	29	to	to	IN
cord-312955-gs65c3fy	133	30	the	the	DT
cord-312955-gs65c3fy	133	31	mouse	mouse	NN
cord-312955-gs65c3fy	133	32	intracellular	intracellular	JJ
cord-312955-gs65c3fy	133	33	domains	domain	NNS
cord-312955-gs65c3fy	133	34	and	and	CC
cord-312955-gs65c3fy	133	35	compared	compare	VBD
cord-312955-gs65c3fy	133	36	the	the	DT
cord-312955-gs65c3fy	133	37	severity	severity	NN
cord-312955-gs65c3fy	133	38	of	of	IN
cord-312955-gs65c3fy	133	39	EAE	EAE	NNP
cord-312955-gs65c3fy	133	40	in	in	IN
cord-312955-gs65c3fy	133	41	a	a	DT
cord-312955-gs65c3fy	133	42	mice	mice	NN
cord-312955-gs65c3fy	133	43	model	model	NN
cord-312955-gs65c3fy	133	44	upon	upon	IN
cord-312955-gs65c3fy	133	45	treatment	treatment	NN
cord-312955-gs65c3fy	133	46	with	with	IN
cord-312955-gs65c3fy	133	47	IFNa2	IFNa2	NNP
cord-312955-gs65c3fy	133	48	,	,	,
cord-312955-gs65c3fy	133	49	IFNb	IFNb	NNS
cord-312955-gs65c3fy	133	50	and	and	CC
cord-312955-gs65c3fy	133	51	the	the	DT
cord-312955-gs65c3fy	133	52	high	high	JJ
cord-312955-gs65c3fy	133	53	-	-	HYPH
cord-312955-gs65c3fy	133	54	affinity	affinity	NN
cord-312955-gs65c3fy	133	55	engineered	engineer	VBN
cord-312955-gs65c3fy	133	56	IFN	IFN	NNP
cord-312955-gs65c3fy	133	57	-	-	HYPH
cord-312955-gs65c3fy	133	58	YNS	YNS	NNP
cord-312955-gs65c3fy	133	59	-	-	HYPH
cord-312955-gs65c3fy	133	60	a8-tail	a8-tail	NNP
cord-312955-gs65c3fy	133	61	.	.	.
cord-312955-gs65c3fy	134	1	We	-PRON-	PRP
cord-312955-gs65c3fy	134	2	found	find	VBD
cord-312955-gs65c3fy	134	3	that	that	IN
cord-312955-gs65c3fy	134	4	the	the	DT
cord-312955-gs65c3fy	134	5	IFN	IFN	NNP
cord-312955-gs65c3fy	134	6	-	-	HYPH
cord-312955-gs65c3fy	134	7	YNS	YNS	NNP
cord-312955-gs65c3fy	134	8	-	-	HYPH
cord-312955-gs65c3fy	134	9	a8-tail	a8-tail	NNP
cord-312955-gs65c3fy	134	10	had	have	VBD
cord-312955-gs65c3fy	134	11	the	the	DT
cord-312955-gs65c3fy	134	12	strongest	strong	JJS
cord-312955-gs65c3fy	134	13	suppressive	suppressive	JJ
cord-312955-gs65c3fy	134	14	effect	effect	NN
cord-312955-gs65c3fy	134	15	on	on	IN
cord-312955-gs65c3fy	134	16	the	the	DT
cord-312955-gs65c3fy	134	17	development	development	NN
cord-312955-gs65c3fy	134	18	of	of	IN
cord-312955-gs65c3fy	134	19	EAE	EAE	NNP
cord-312955-gs65c3fy	134	20	(	(	-LRB-
cord-312955-gs65c3fy	134	21	57	57	CD
cord-312955-gs65c3fy	134	22	)	)	-RRB-
cord-312955-gs65c3fy	134	23	.	.	.
cord-312955-gs65c3fy	135	1	The	the	DT
cord-312955-gs65c3fy	135	2	effect	effect	NN
cord-312955-gs65c3fy	135	3	was	be	VBD
cord-312955-gs65c3fy	135	4	further	further	RB
cord-312955-gs65c3fy	135	5	enhanced	enhance	VBN
cord-312955-gs65c3fy	135	6	by	by	IN
cord-312955-gs65c3fy	135	7	PASylation	pasylation	NN
cord-312955-gs65c3fy	135	8	of	of	IN
cord-312955-gs65c3fy	135	9	IFN	IFN	NNP
cord-312955-gs65c3fy	135	10	-	-	HYPH
cord-312955-gs65c3fy	135	11	YNS	YNS	NNP
cord-312955-gs65c3fy	135	12	-	-	HYPH
cord-312955-gs65c3fy	135	13	a8-tail	a8-tail	NNP
cord-312955-gs65c3fy	135	14	,	,	,
cord-312955-gs65c3fy	135	15	which	which	WDT
cord-312955-gs65c3fy	135	16	extends	extend	VBZ
cord-312955-gs65c3fy	135	17	it	-PRON-	PRP
cord-312955-gs65c3fy	135	18	plasma	plasma	VBD
cord-312955-gs65c3fy	135	19	half	half	JJ
cord-312955-gs65c3fy	135	20	-	-	HYPH
cord-312955-gs65c3fy	135	21	life	life	NN
cord-312955-gs65c3fy	135	22	by	by	IN
cord-312955-gs65c3fy	135	23	10-fold	10-fold	CD
cord-312955-gs65c3fy	135	24	.	.	.
cord-312955-gs65c3fy	136	1	Interestingly	interestingly	RB
cord-312955-gs65c3fy	136	2	,	,	,
cord-312955-gs65c3fy	136	3	we	-PRON-	PRP
cord-312955-gs65c3fy	136	4	found	find	VBD
cord-312955-gs65c3fy	136	5	a	a	DT
cord-312955-gs65c3fy	136	6	tight	tight	JJ
cord-312955-gs65c3fy	136	7	relation	relation	NN
cord-312955-gs65c3fy	136	8	between	between	IN
cord-312955-gs65c3fy	136	9	the	the	DT
cord-312955-gs65c3fy	136	10	increased	increase	VBN
cord-312955-gs65c3fy	136	11	levels	level	NNS
cord-312955-gs65c3fy	136	12	of	of	IN
cord-312955-gs65c3fy	136	13	expression	expression	NN
cord-312955-gs65c3fy	136	14	of	of	IN
cord-312955-gs65c3fy	136	15	PD	PD	NNP
cord-312955-gs65c3fy	136	16	-	-	HYPH
cord-312955-gs65c3fy	136	17	L1	L1	NNP
cord-312955-gs65c3fy	136	18	in	in	IN
cord-312955-gs65c3fy	136	19	mice	mouse	NNS
cord-312955-gs65c3fy	136	20	and	and	CC
cord-312955-gs65c3fy	136	21	the	the	DT
cord-312955-gs65c3fy	136	22	severity	severity	NN
cord-312955-gs65c3fy	136	23	of	of	IN
cord-312955-gs65c3fy	136	24	the	the	DT
cord-312955-gs65c3fy	136	25	disease	disease	NN
cord-312955-gs65c3fy	136	26	.	.	.
cord-312955-gs65c3fy	137	1	These	these	DT
cord-312955-gs65c3fy	137	2	data	datum	NNS
cord-312955-gs65c3fy	137	3	show	show	VBP
cord-312955-gs65c3fy	137	4	that	that	IN
cord-312955-gs65c3fy	137	5	tight	tight	JJ
cord-312955-gs65c3fy	137	6	binding	bind	VBG
cord-312955-gs65c3fy	137	7	IFN	IFN	NNP
cord-312955-gs65c3fy	137	8	-	-	:
cord-312955-gs65c3fy	137	9	Is	be	VBZ
cord-312955-gs65c3fy	137	10	induce	induce	VB
cord-312955-gs65c3fy	137	11	preferential	preferential	JJ
cord-312955-gs65c3fy	137	12	anti	anti	JJ
cord-312955-gs65c3fy	137	13	-	-	JJ
cord-312955-gs65c3fy	137	14	inflammatory	inflammatory	JJ
cord-312955-gs65c3fy	137	15	responses	response	NNS
cord-312955-gs65c3fy	137	16	,	,	,
cord-312955-gs65c3fy	137	17	at	at	IN
cord-312955-gs65c3fy	137	18	least	least	JJS
cord-312955-gs65c3fy	137	19	in	in	IN
cord-312955-gs65c3fy	137	20	this	this	DT
cord-312955-gs65c3fy	137	21	MS	MS	NNP
cord-312955-gs65c3fy	137	22	mouse	mouse	NN
cord-312955-gs65c3fy	137	23	model	model	NN
cord-312955-gs65c3fy	137	24	.	.	.
cord-312955-gs65c3fy	138	1	Another	another	DT
cord-312955-gs65c3fy	138	2	example	example	NN
cord-312955-gs65c3fy	138	3	for	for	IN
cord-312955-gs65c3fy	138	4	the	the	DT
cord-312955-gs65c3fy	138	5	immunosuppressive	immunosuppressive	JJ
cord-312955-gs65c3fy	138	6	activity	activity	NN
cord-312955-gs65c3fy	138	7	of	of	IN
cord-312955-gs65c3fy	138	8	IFN	IFN	NNP
cord-312955-gs65c3fy	138	9	-	-	HYPH
cord-312955-gs65c3fy	138	10	I	-PRON-	PRP
cord-312955-gs65c3fy	138	11	was	be	VBD
cord-312955-gs65c3fy	138	12	shown	show	VBN
cord-312955-gs65c3fy	138	13	for	for	IN
cord-312955-gs65c3fy	138	14	LCMV	LCMV	NNP
cord-312955-gs65c3fy	138	15	infection	infection	NN
cord-312955-gs65c3fy	138	16	,	,	,
cord-312955-gs65c3fy	138	17	which	which	WDT
cord-312955-gs65c3fy	138	18	induces	induce	VBZ
cord-312955-gs65c3fy	138	19	consistent	consistent	JJ
cord-312955-gs65c3fy	138	20	IFN	IFN	NNP
cord-312955-gs65c3fy	138	21	-	-	HYPH
cord-312955-gs65c3fy	138	22	I	-PRON-	PRP
cord-312955-gs65c3fy	138	23	production	production	NN
cord-312955-gs65c3fy	138	24	including	include	VBG
cord-312955-gs65c3fy	138	25	the	the	DT
cord-312955-gs65c3fy	138	26	immunosuppressive	immunosuppressive	JJ
cord-312955-gs65c3fy	138	27	factors	factor	NNS
cord-312955-gs65c3fy	138	28	IL-10	IL-10	NNP
cord-312955-gs65c3fy	138	29	and	and	CC
cord-312955-gs65c3fy	138	30	PD	PD	NNP
cord-312955-gs65c3fy	138	31	-	-	HYPH
cord-312955-gs65c3fy	138	32	L1	L1	NNP
cord-312955-gs65c3fy	138	33	(	(	-LRB-
cord-312955-gs65c3fy	138	34	58	58	CD
cord-312955-gs65c3fy	138	35	)	)	-RRB-
cord-312955-gs65c3fy	138	36	.	.	.
cord-312955-gs65c3fy	139	1	In	in	IN
cord-312955-gs65c3fy	139	2	addition	addition	NN
cord-312955-gs65c3fy	139	3	to	to	IN
cord-312955-gs65c3fy	139	4	the	the	DT
cord-312955-gs65c3fy	139	5	above	above	JJ
cord-312955-gs65c3fy	139	6	,	,	,
cord-312955-gs65c3fy	139	7	Interferons	interferon	NNS
cord-312955-gs65c3fy	139	8	contribute	contribute	VBP
cord-312955-gs65c3fy	139	9	to	to	IN
cord-312955-gs65c3fy	139	10	inflammasome	inflammasome	NN
cord-312955-gs65c3fy	139	11	activation	activation	NN
cord-312955-gs65c3fy	139	12	through	through	IN
cord-312955-gs65c3fy	139	13	several	several	JJ
cord-312955-gs65c3fy	139	14	different	different	JJ
cord-312955-gs65c3fy	139	15	mechanisms	mechanism	NNS
cord-312955-gs65c3fy	139	16	,	,	,
cord-312955-gs65c3fy	139	17	including	include	VBG
cord-312955-gs65c3fy	139	18	caspase-11	caspase-11	JJ
cord-312955-gs65c3fy	139	19	expression	expression	NN
cord-312955-gs65c3fy	139	20	and	and	CC
cord-312955-gs65c3fy	139	21	the	the	DT
cord-312955-gs65c3fy	139	22	IFN	IFN	NNP
cord-312955-gs65c3fy	139	23	-	-	HYPH
cord-312955-gs65c3fy	139	24	I	I	NNP
cord-312955-gs65c3fy	139	25	inducible	inducible	JJ
cord-312955-gs65c3fy	139	26	GBP	GBP	NNP
cord-312955-gs65c3fy	139	27	protein	protein	NN
cord-312955-gs65c3fy	139	28	expression	expression	NN
cord-312955-gs65c3fy	139	29	,	,	,
cord-312955-gs65c3fy	139	30	which	which	WDT
cord-312955-gs65c3fy	139	31	was	be	VBD
cord-312955-gs65c3fy	139	32	reported	report	VBN
cord-312955-gs65c3fy	139	33	to	to	TO
cord-312955-gs65c3fy	139	34	have	have	VB
cord-312955-gs65c3fy	139	35	an	an	DT
cord-312955-gs65c3fy	139	36	important	important	JJ
cord-312955-gs65c3fy	139	37	role	role	NN
cord-312955-gs65c3fy	139	38	in	in	IN
cord-312955-gs65c3fy	139	39	caspase-11	caspase-11	CD
cord-312955-gs65c3fy	139	40	activation	activation	NN
cord-312955-gs65c3fy	139	41	and	and	CC
cord-312955-gs65c3fy	139	42	pyroptotic	pyroptotic	JJ
cord-312955-gs65c3fy	139	43	cell	cell	NN
cord-312955-gs65c3fy	139	44	death	death	NN
cord-312955-gs65c3fy	139	45	(	(	-LRB-
cord-312955-gs65c3fy	139	46	59	59	CD
cord-312955-gs65c3fy	139	47	)	)	-RRB-
cord-312955-gs65c3fy	139	48	.	.	.
cord-312955-gs65c3fy	140	1	IFN	IFN	NNP
cord-312955-gs65c3fy	140	2	-	-	:
cord-312955-gs65c3fy	140	3	Is	be	VBZ
cord-312955-gs65c3fy	140	4	have	have	VB
cord-312955-gs65c3fy	140	5	important	important	JJ
cord-312955-gs65c3fy	140	6	roles	role	NNS
cord-312955-gs65c3fy	140	7	in	in	IN
cord-312955-gs65c3fy	140	8	protecting	protect	VBG
cord-312955-gs65c3fy	140	9	the	the	DT
cord-312955-gs65c3fy	140	10	lung	lung	NN
cord-312955-gs65c3fy	140	11	from	from	IN
cord-312955-gs65c3fy	140	12	spread	spread	NN
cord-312955-gs65c3fy	140	13	of	of	IN
cord-312955-gs65c3fy	140	14	respiratory	respiratory	JJ
cord-312955-gs65c3fy	140	15	viruses	virus	NNS
cord-312955-gs65c3fy	140	16	.	.	.
cord-312955-gs65c3fy	141	1	In	in	IN
cord-312955-gs65c3fy	141	2	addition	addition	NN
cord-312955-gs65c3fy	141	3	to	to	IN
cord-312955-gs65c3fy	141	4	their	-PRON-	PRP$
cord-312955-gs65c3fy	141	5	direct	direct	JJ
cord-312955-gs65c3fy	141	6	role	role	NN
cord-312955-gs65c3fy	141	7	,	,	,
cord-312955-gs65c3fy	141	8	IFN	IFN	NNP
cord-312955-gs65c3fy	141	9	-	-	:
cord-312955-gs65c3fy	141	10	Is	be	VBZ
cord-312955-gs65c3fy	141	11	have	have	VBP
cord-312955-gs65c3fy	141	12	also	also	RB
cord-312955-gs65c3fy	141	13	been	be	VBN
cord-312955-gs65c3fy	141	14	found	find	VBN
cord-312955-gs65c3fy	141	15	to	to	TO
cord-312955-gs65c3fy	141	16	be	be	VB
cord-312955-gs65c3fy	141	17	critical	critical	JJ
cord-312955-gs65c3fy	141	18	in	in	IN
cord-312955-gs65c3fy	141	19	initiating	initiate	VBG
cord-312955-gs65c3fy	141	20	lung	lung	NN
cord-312955-gs65c3fy	141	21	inflammatory	inflammatory	JJ
cord-312955-gs65c3fy	141	22	responses	response	NNS
cord-312955-gs65c3fy	141	23	,	,	,
cord-312955-gs65c3fy	141	24	by	by	IN
cord-312955-gs65c3fy	141	25	inducing	induce	VBG
cord-312955-gs65c3fy	141	26	recruitment	recruitment	NN
cord-312955-gs65c3fy	141	27	and	and	CC
cord-312955-gs65c3fy	141	28	activation	activation	NN
cord-312955-gs65c3fy	141	29	of	of	IN
cord-312955-gs65c3fy	141	30	immune	immune	JJ
cord-312955-gs65c3fy	141	31	responses	response	NNS
cord-312955-gs65c3fy	141	32	,	,	,
cord-312955-gs65c3fy	141	33	which	which	WDT
cord-312955-gs65c3fy	141	34	have	have	VBP
cord-312955-gs65c3fy	141	35	to	to	TO
cord-312955-gs65c3fy	141	36	be	be	VB
cord-312955-gs65c3fy	141	37	kept	keep	VBN
cord-312955-gs65c3fy	141	38	under	under	IN
cord-312955-gs65c3fy	141	39	control	control	NN
cord-312955-gs65c3fy	141	40	.	.	.
cord-312955-gs65c3fy	142	1	IFN	IFN	NNP
cord-312955-gs65c3fy	142	2	-	-	:
cord-312955-gs65c3fy	142	3	Is	be	VBZ
cord-312955-gs65c3fy	142	4	have	have	VBP
cord-312955-gs65c3fy	142	5	been	be	VBN
cord-312955-gs65c3fy	142	6	shown	show	VBN
cord-312955-gs65c3fy	142	7	to	to	TO
cord-312955-gs65c3fy	142	8	result	result	VB
cord-312955-gs65c3fy	142	9	in	in	IN
cord-312955-gs65c3fy	142	10	the	the	DT
cord-312955-gs65c3fy	142	11	production	production	NN
cord-312955-gs65c3fy	142	12	of	of	IN
cord-312955-gs65c3fy	142	13	chemokines	chemokine	NNS
cord-312955-gs65c3fy	142	14	such	such	JJ
cord-312955-gs65c3fy	142	15	as	as	IN
cord-312955-gs65c3fy	142	16	CCL2	CCL2	NNP
cord-312955-gs65c3fy	142	17	and	and	CC
cord-312955-gs65c3fy	142	18	CXCL10	CXCL10	NNP
cord-312955-gs65c3fy	142	19	,	,	,
cord-312955-gs65c3fy	142	20	which	which	WDT
cord-312955-gs65c3fy	142	21	play	play	VBP
cord-312955-gs65c3fy	142	22	important	important	JJ
cord-312955-gs65c3fy	142	23	roles	role	NNS
cord-312955-gs65c3fy	142	24	in	in	IN
cord-312955-gs65c3fy	142	25	the	the	DT
cord-312955-gs65c3fy	142	26	recruitment	recruitment	NN
cord-312955-gs65c3fy	142	27	of	of	IN
cord-312955-gs65c3fy	142	28	monocytes	monocyte	NNS
cord-312955-gs65c3fy	142	29	/	/	SYM
cord-312955-gs65c3fy	142	30	macrophages	macrophage	NNS
cord-312955-gs65c3fy	142	31	,	,	,
cord-312955-gs65c3fy	142	32	T	t	NN
cord-312955-gs65c3fy	142	33	cells	cell	NNS
cord-312955-gs65c3fy	142	34	,	,	,
cord-312955-gs65c3fy	142	35	NK	NK	NNP
cord-312955-gs65c3fy	142	36	cells	cell	NNS
cord-312955-gs65c3fy	142	37	,	,	,
cord-312955-gs65c3fy	142	38	and	and	CC
cord-312955-gs65c3fy	142	39	DCs	DCs	NNP
cord-312955-gs65c3fy	142	40	,	,	,
cord-312955-gs65c3fy	142	41	therefore	therefore	RB
cord-312955-gs65c3fy	142	42	directly	directly	RB
cord-312955-gs65c3fy	142	43	influencing	influence	VBG
cord-312955-gs65c3fy	142	44	inflammation	inflammation	NN
cord-312955-gs65c3fy	142	45	in	in	IN
cord-312955-gs65c3fy	142	46	the	the	DT
cord-312955-gs65c3fy	142	47	lung	lung	NN
cord-312955-gs65c3fy	142	48	(	(	-LRB-
cord-312955-gs65c3fy	142	49	60	60	CD
cord-312955-gs65c3fy	142	50	)	)	-RRB-
cord-312955-gs65c3fy	142	51	.	.	.
cord-312955-gs65c3fy	143	1	This	this	DT
cord-312955-gs65c3fy	143	2	varied	varied	JJ
cord-312955-gs65c3fy	143	3	effect	effect	NN
cord-312955-gs65c3fy	143	4	of	of	IN
cord-312955-gs65c3fy	143	5	type	type	NN
cord-312955-gs65c3fy	144	1	I	-PRON-	PRP
cord-312955-gs65c3fy	144	2	IFNs	ifns	VBP
cord-312955-gs65c3fy	144	3	on	on	IN
cord-312955-gs65c3fy	144	4	T	t	NN
cord-312955-gs65c3fy	144	5	cells	cell	NNS
cord-312955-gs65c3fy	144	6	is	be	VBZ
cord-312955-gs65c3fy	144	7	partly	partly	RB
cord-312955-gs65c3fy	144	8	dependent	dependent	JJ
cord-312955-gs65c3fy	144	9	on	on	IN
cord-312955-gs65c3fy	144	10	the	the	DT
cord-312955-gs65c3fy	144	11	different	different	JJ
cord-312955-gs65c3fy	144	12	STATs	stat	NNS
cord-312955-gs65c3fy	144	13	induced	induce	VBN
cord-312955-gs65c3fy	144	14	by	by	IN
cord-312955-gs65c3fy	144	15	type	type	NN
cord-312955-gs65c3fy	144	16	I	-PRON-	PRP
cord-312955-gs65c3fy	144	17	IFNs	ifns	VBP
cord-312955-gs65c3fy	144	18	.	.	.
cord-312955-gs65c3fy	145	1	In	in	IN
cord-312955-gs65c3fy	145	2	the	the	DT
cord-312955-gs65c3fy	145	3	absence	absence	NN
cord-312955-gs65c3fy	145	4	of	of	IN
cord-312955-gs65c3fy	145	5	IFN	IFN	NNP
cord-312955-gs65c3fy	145	6	-	-	HYPH
cord-312955-gs65c3fy	145	7	Is	be	VBZ
cord-312955-gs65c3fy	145	8	,	,	,
cord-312955-gs65c3fy	145	9	the	the	DT
cord-312955-gs65c3fy	145	10	detection	detection	NN
cord-312955-gs65c3fy	145	11	of	of	IN
cord-312955-gs65c3fy	145	12	accumulating	accumulate	VBG
cord-312955-gs65c3fy	145	13	viral	viral	JJ
cord-312955-gs65c3fy	145	14	RNA	RNA	NNP
cord-312955-gs65c3fy	145	15	and	and	CC
cord-312955-gs65c3fy	145	16	downstream	downstream	JJ
cord-312955-gs65c3fy	145	17	processing	processing	NN
cord-312955-gs65c3fy	145	18	of	of	IN
cord-312955-gs65c3fy	145	19	the	the	DT
cord-312955-gs65c3fy	145	20	signal	signal	NN
cord-312955-gs65c3fy	145	21	is	be	VBZ
cord-312955-gs65c3fy	145	22	compromised	compromise	VBN
cord-312955-gs65c3fy	145	23	,	,	,
cord-312955-gs65c3fy	145	24	leading	lead	VBG
cord-312955-gs65c3fy	145	25	to	to	IN
cord-312955-gs65c3fy	145	26	viral	viral	JJ
cord-312955-gs65c3fy	145	27	spread	spread	NN
cord-312955-gs65c3fy	145	28	and	and	CC
cord-312955-gs65c3fy	145	29	also	also	RB
cord-312955-gs65c3fy	145	30	to	to	IN
cord-312955-gs65c3fy	145	31	reduced	reduce	VBN
cord-312955-gs65c3fy	145	32	inflammation	inflammation	NN
cord-312955-gs65c3fy	145	33	in	in	IN
cord-312955-gs65c3fy	145	34	the	the	DT
cord-312955-gs65c3fy	145	35	lung	lung	NN
cord-312955-gs65c3fy	145	36	.	.	.
cord-312955-gs65c3fy	146	1	Interestingly	interestingly	RB
cord-312955-gs65c3fy	146	2	,	,	,
cord-312955-gs65c3fy	146	3	there	there	EX
cord-312955-gs65c3fy	146	4	is	be	VBZ
cord-312955-gs65c3fy	146	5	an	an	DT
cord-312955-gs65c3fy	146	6	age	age	NN
cord-312955-gs65c3fy	146	7	-	-	HYPH
cord-312955-gs65c3fy	146	8	related	relate	VBN
cord-312955-gs65c3fy	146	9	reduction	reduction	NN
cord-312955-gs65c3fy	146	10	of	of	IN
cord-312955-gs65c3fy	146	11	IFN	IFN	NNP
cord-312955-gs65c3fy	146	12	-	-	HYPH
cord-312955-gs65c3fy	146	13	I	-PRON-	PRP
cord-312955-gs65c3fy	146	14	production	production	NN
cord-312955-gs65c3fy	146	15	and	and	CC
cord-312955-gs65c3fy	146	16	ISG	ISG	NNP
cord-312955-gs65c3fy	146	17	induction	induction	NN
cord-312955-gs65c3fy	146	18	after	after	IN
cord-312955-gs65c3fy	146	19	viral	viral	JJ
cord-312955-gs65c3fy	146	20	infection	infection	NN
cord-312955-gs65c3fy	146	21	,	,	,
cord-312955-gs65c3fy	146	22	which	which	WDT
cord-312955-gs65c3fy	146	23	may	may	MD
cord-312955-gs65c3fy	146	24	be	be	VB
cord-312955-gs65c3fy	146	25	related	relate	VBN
cord-312955-gs65c3fy	146	26	to	to	IN
cord-312955-gs65c3fy	146	27	the	the	DT
cord-312955-gs65c3fy	146	28	higher	high	JJR
cord-312955-gs65c3fy	146	29	susceptibility	susceptibility	NN
cord-312955-gs65c3fy	146	30	of	of	IN
cord-312955-gs65c3fy	146	31	elderly	elderly	JJ
cord-312955-gs65c3fy	146	32	population	population	NN
cord-312955-gs65c3fy	146	33	to	to	IN
cord-312955-gs65c3fy	146	34	lung	lung	NN
cord-312955-gs65c3fy	146	35	infections	infection	NNS
cord-312955-gs65c3fy	146	36	(	(	-LRB-
cord-312955-gs65c3fy	146	37	61	61	CD
cord-312955-gs65c3fy	146	38	)	)	-RRB-
cord-312955-gs65c3fy	146	39	.	.	.
cord-312955-gs65c3fy	147	1	Viruses	virus	NNS
cord-312955-gs65c3fy	147	2	have	have	VBP
cord-312955-gs65c3fy	147	3	developed	develop	VBN
cord-312955-gs65c3fy	147	4	many	many	JJ
cord-312955-gs65c3fy	147	5	strategies	strategy	NNS
cord-312955-gs65c3fy	147	6	to	to	TO
cord-312955-gs65c3fy	147	7	interfere	interfere	VB
cord-312955-gs65c3fy	147	8	with	with	IN
cord-312955-gs65c3fy	147	9	the	the	DT
cord-312955-gs65c3fy	147	10	synthesis	synthesis	NN
cord-312955-gs65c3fy	147	11	of	of	IN
cord-312955-gs65c3fy	148	1	IFN	IFN	NNP
cord-312955-gs65c3fy	148	2	-	-	HYPH
cord-312955-gs65c3fy	148	3	Is	be	VBZ
cord-312955-gs65c3fy	148	4	or	or	CC
cord-312955-gs65c3fy	148	5	the	the	DT
cord-312955-gs65c3fy	148	6	IFN	IFN	NNP
cord-312955-gs65c3fy	148	7	-	-	HYPH
cord-312955-gs65c3fy	148	8	I	I	NNP
cord-312955-gs65c3fy	148	9	induced	induce	VBD
cord-312955-gs65c3fy	148	10	responses	response	NNS
cord-312955-gs65c3fy	148	11	.	.	.
cord-312955-gs65c3fy	149	1	One	one	CD
cord-312955-gs65c3fy	149	2	of	of	IN
cord-312955-gs65c3fy	149	3	them	-PRON-	PRP
cord-312955-gs65c3fy	149	4	,	,	,
cord-312955-gs65c3fy	149	5	is	be	VBZ
cord-312955-gs65c3fy	149	6	the	the	DT
cord-312955-gs65c3fy	149	7	stimulation	stimulation	NN
cord-312955-gs65c3fy	149	8	of	of	IN
cord-312955-gs65c3fy	149	9	turnover	turnover	NN
cord-312955-gs65c3fy	149	10	of	of	IN
cord-312955-gs65c3fy	149	11	the	the	DT
cord-312955-gs65c3fy	149	12	interferon	interferon	NN
cord-312955-gs65c3fy	149	13	receptors	receptor	NNS
cord-312955-gs65c3fy	149	14	.	.	.
cord-312955-gs65c3fy	150	1	Among	among	IN
cord-312955-gs65c3fy	150	2	other	other	JJ
cord-312955-gs65c3fy	150	3	viruses	virus	NNS
cord-312955-gs65c3fy	150	4	implicated	implicate	VBN
cord-312955-gs65c3fy	150	5	in	in	IN
cord-312955-gs65c3fy	150	6	accelerating	accelerate	VBG
cord-312955-gs65c3fy	150	7	the	the	DT
cord-312955-gs65c3fy	150	8	turnover	turnover	NN
cord-312955-gs65c3fy	150	9	of	of	IN
cord-312955-gs65c3fy	150	10	IFNAR1	ifnar1	NN
cord-312955-gs65c3fy	150	11	are	be	VBP
cord-312955-gs65c3fy	150	12	EBV	EBV	NNP
cord-312955-gs65c3fy	150	13	,	,	,
cord-312955-gs65c3fy	150	14	herpes	herpes	NN
cord-312955-gs65c3fy	150	15	simplex	simplex	NNP
cord-312955-gs65c3fy	150	16	virus	virus	NN
cord-312955-gs65c3fy	150	17	,	,	,
cord-312955-gs65c3fy	150	18	hepatitis	hepatitis	NN
cord-312955-gs65c3fy	150	19	C	C	NNP
cord-312955-gs65c3fy	150	20	and	and	CC
cord-312955-gs65c3fy	150	21	B	b	NN
cord-312955-gs65c3fy	150	22	viruses	virus	NNS
cord-312955-gs65c3fy	150	23	,	,	,
cord-312955-gs65c3fy	150	24	vesicular	vesicular	JJ
cord-312955-gs65c3fy	150	25	stomatitis	stomatitis	NN
cord-312955-gs65c3fy	150	26	virus	virus	NN
cord-312955-gs65c3fy	150	27	and	and	CC
cord-312955-gs65c3fy	150	28	the	the	DT
cord-312955-gs65c3fy	150	29	SARS	SARS	NNP
cord-312955-gs65c3fy	150	30	coronavirus	coronavirus	NN
cord-312955-gs65c3fy	150	31	(	(	-LRB-
cord-312955-gs65c3fy	150	32	62	62	CD
cord-312955-gs65c3fy	150	33	,	,	,
cord-312955-gs65c3fy	150	34	63	63	CD
cord-312955-gs65c3fy	150	35	)	)	-RRB-
cord-312955-gs65c3fy	150	36	.	.	.
cord-312955-gs65c3fy	151	1	SARS	SARS	NNP
cord-312955-gs65c3fy	151	2	-	-	HYPH
cord-312955-gs65c3fy	151	3	CoV	CoV	NNP
cord-312955-gs65c3fy	151	4	has	have	VBZ
cord-312955-gs65c3fy	151	5	been	be	VBN
cord-312955-gs65c3fy	151	6	shown	show	VBN
cord-312955-gs65c3fy	151	7	to	to	TO
cord-312955-gs65c3fy	151	8	suppress	suppress	VB
cord-312955-gs65c3fy	151	9	IFN	IFN	NNP
cord-312955-gs65c3fy	151	10	-	-	HYPH
cord-312955-gs65c3fy	151	11	I	-PRON-	PRP
cord-312955-gs65c3fy	151	12	responses	response	NNS
cord-312955-gs65c3fy	151	13	in	in	IN
cord-312955-gs65c3fy	151	14	the	the	DT
cord-312955-gs65c3fy	151	15	host	host	NN
cord-312955-gs65c3fy	151	16	through	through	IN
cord-312955-gs65c3fy	151	17	multiple	multiple	JJ
cord-312955-gs65c3fy	151	18	mechanisms	mechanism	NNS
cord-312955-gs65c3fy	151	19	.	.	.
cord-312955-gs65c3fy	152	1	A	a	DT
cord-312955-gs65c3fy	152	2	subdued	subdue	VBN
cord-312955-gs65c3fy	152	3	IFN	IFN	NNP
cord-312955-gs65c3fy	152	4	-	-	HYPH
cord-312955-gs65c3fy	152	5	I	-PRON-	PRP
cord-312955-gs65c3fy	152	6	response	response	NN
cord-312955-gs65c3fy	152	7	diminishes	diminish	VBZ
cord-312955-gs65c3fy	152	8	antigen	antigen	NN
cord-312955-gs65c3fy	152	9	presentation	presentation	NN
cord-312955-gs65c3fy	152	10	and	and	CC
cord-312955-gs65c3fy	152	11	reduces	reduce	VBZ
cord-312955-gs65c3fy	152	12	the	the	DT
cord-312955-gs65c3fy	152	13	antiviral	antiviral	JJ
cord-312955-gs65c3fy	152	14	adaptive	adaptive	JJ
cord-312955-gs65c3fy	152	15	Th-1	Th-1	NNP
cord-312955-gs65c3fy	152	16	immune	immune	JJ
cord-312955-gs65c3fy	152	17	response	response	NN
cord-312955-gs65c3fy	152	18	.	.	.
cord-312955-gs65c3fy	153	1	IFN	IFN	NNP
cord-312955-gs65c3fy	153	2	-	-	:
cord-312955-gs65c3fy	153	3	Is	be	VBZ
cord-312955-gs65c3fy	153	4	communicate	communicate	VB
cord-312955-gs65c3fy	153	5	between	between	IN
cord-312955-gs65c3fy	153	6	cells	cell	NNS
cord-312955-gs65c3fy	153	7	against	against	IN
cord-312955-gs65c3fy	153	8	pathogens	pathogen	NNS
cord-312955-gs65c3fy	153	9	and	and	CC
cord-312955-gs65c3fy	153	10	have	have	VBP
cord-312955-gs65c3fy	153	11	a	a	DT
cord-312955-gs65c3fy	153	12	critical	critical	JJ
cord-312955-gs65c3fy	153	13	role	role	NN
cord-312955-gs65c3fy	153	14	in	in	IN
cord-312955-gs65c3fy	153	15	the	the	DT
cord-312955-gs65c3fy	153	16	immune	immune	JJ
cord-312955-gs65c3fy	153	17	system	system	NN
cord-312955-gs65c3fy	153	18	,	,	,
cord-312955-gs65c3fy	153	19	such	such	JJ
cord-312955-gs65c3fy	153	20	as	as	IN
cord-312955-gs65c3fy	153	21	activating	activate	VBG
cord-312955-gs65c3fy	153	22	natural	natural	JJ
cord-312955-gs65c3fy	153	23	killer	killer	NN
cord-312955-gs65c3fy	153	24	(	(	-LRB-
cord-312955-gs65c3fy	153	25	NK	NK	NNP
cord-312955-gs65c3fy	153	26	)	)	-RRB-
cord-312955-gs65c3fy	153	27	cells	cell	NNS
cord-312955-gs65c3fy	153	28	and	and	CC
cord-312955-gs65c3fy	153	29	macrophages	macrophage	NNS
cord-312955-gs65c3fy	153	30	.	.	.
cord-312955-gs65c3fy	154	1	In	in	IN
cord-312955-gs65c3fy	154	2	addition	addition	NN
cord-312955-gs65c3fy	154	3	,	,	,
cord-312955-gs65c3fy	154	4	IFN	IFN	NNP
cord-312955-gs65c3fy	154	5	-	-	:
cord-312955-gs65c3fy	154	6	Is	be	VBZ
cord-312955-gs65c3fy	154	7	cause	cause	VB
cord-312955-gs65c3fy	154	8	flu	flu	NN
cord-312955-gs65c3fy	154	9	-	-	HYPH
cord-312955-gs65c3fy	154	10	like	like	JJ
cord-312955-gs65c3fy	154	11	symptoms	symptom	NNS
cord-312955-gs65c3fy	154	12	,	,	,
cord-312955-gs65c3fy	154	13	which	which	WDT
cord-312955-gs65c3fy	154	14	are	be	VBP
cord-312955-gs65c3fy	154	15	observed	observe	VBN
cord-312955-gs65c3fy	154	16	in	in	IN
cord-312955-gs65c3fy	154	17	various	various	JJ
cord-312955-gs65c3fy	154	18	diseases	disease	NNS
cord-312955-gs65c3fy	154	19	.	.	.
cord-312955-gs65c3fy	155	1	These	these	DT
cord-312955-gs65c3fy	155	2	symptoms	symptom	NNS
cord-312955-gs65c3fy	155	3	may	may	MD
cord-312955-gs65c3fy	155	4	have	have	VB
cord-312955-gs65c3fy	155	5	a	a	DT
cord-312955-gs65c3fy	155	6	role	role	NN
cord-312955-gs65c3fy	155	7	in	in	IN
cord-312955-gs65c3fy	155	8	alerting	alert	VBG
cord-312955-gs65c3fy	155	9	a	a	DT
cord-312955-gs65c3fy	155	10	person	person	NN
cord-312955-gs65c3fy	155	11	of	of	IN
cord-312955-gs65c3fy	155	12	his	-PRON-	PRP$
cord-312955-gs65c3fy	155	13	/	/	SYM
cord-312955-gs65c3fy	155	14	her	-PRON-	PRP$
cord-312955-gs65c3fy	155	15	sickness	sickness	NN
cord-312955-gs65c3fy	155	16	,	,	,
cord-312955-gs65c3fy	155	17	in	in	IN
cord-312955-gs65c3fy	155	18	order	order	NN
cord-312955-gs65c3fy	155	19	to	to	TO
cord-312955-gs65c3fy	155	20	limit	limit	VB
cord-312955-gs65c3fy	155	21	disease	disease	NN
cord-312955-gs65c3fy	155	22	-	-	HYPH
cord-312955-gs65c3fy	155	23	spread	spread	VBN
cord-312955-gs65c3fy	155	24	to	to	IN
cord-312955-gs65c3fy	155	25	other	other	JJ
cord-312955-gs65c3fy	155	26	individuals	individual	NNS
cord-312955-gs65c3fy	155	27	.	.	.
cord-312955-gs65c3fy	156	1	In	in	IN
cord-312955-gs65c3fy	156	2	SARS	SARS	NNP
cord-312955-gs65c3fy	156	3	-	-	HYPH
cord-312955-gs65c3fy	156	4	CoV	CoV	NNP
cord-312955-gs65c3fy	156	5	and	and	CC
cord-312955-gs65c3fy	156	6	MERS	MERS	NNP
cord-312955-gs65c3fy	156	7	-	-	HYPH
cord-312955-gs65c3fy	156	8	CoV	CoV	NNP
cord-312955-gs65c3fy	156	9	,	,	,
cord-312955-gs65c3fy	156	10	the	the	DT
cord-312955-gs65c3fy	156	11	induction	induction	NN
cord-312955-gs65c3fy	156	12	of	of	IN
cord-312955-gs65c3fy	156	13	IFNb	IFNb	NNPS
cord-312955-gs65c3fy	156	14	is	be	VBZ
cord-312955-gs65c3fy	156	15	suppressed	suppress	VBN
cord-312955-gs65c3fy	156	16	altogether	altogether	RB
cord-312955-gs65c3fy	156	17	.	.	.
cord-312955-gs65c3fy	157	1	This	this	DT
cord-312955-gs65c3fy	157	2	dampening	dampen	VBG
cord-312955-gs65c3fy	157	3	approach	approach	NN
cord-312955-gs65c3fy	157	4	is	be	VBZ
cord-312955-gs65c3fy	157	5	highly	highly	RB
cord-312955-gs65c3fy	157	6	associated	associate	VBN
cord-312955-gs65c3fy	157	7	with	with	IN
cord-312955-gs65c3fy	157	8	the	the	DT
cord-312955-gs65c3fy	157	9	disease	disease	NN
cord-312955-gs65c3fy	157	10	severity	severity	NN
cord-312955-gs65c3fy	157	11	and	and	CC
cord-312955-gs65c3fy	157	12	increased	increase	VBN
cord-312955-gs65c3fy	157	13	mortality	mortality	NN
cord-312955-gs65c3fy	157	14	(	(	-LRB-
cord-312955-gs65c3fy	157	15	64	64	CD
cord-312955-gs65c3fy	157	16	)	)	-RRB-
cord-312955-gs65c3fy	157	17	.	.	.
cord-312955-gs65c3fy	158	1	In	in	IN
cord-312955-gs65c3fy	158	2	the	the	DT
cord-312955-gs65c3fy	158	3	lethal	lethal	JJ
cord-312955-gs65c3fy	158	4	cases	case	NNS
cord-312955-gs65c3fy	158	5	of	of	IN
cord-312955-gs65c3fy	158	6	SARS	SARS	NNP
cord-312955-gs65c3fy	158	7	-	-	HYPH
cord-312955-gs65c3fy	158	8	CoV	CoV	NNP
cord-312955-gs65c3fy	158	9	or	or	CC
cord-312955-gs65c3fy	158	10	MERS	MERS	NNP
cord-312955-gs65c3fy	158	11	-	-	HYPH
cord-312955-gs65c3fy	158	12	CoV	cov	NN
cord-312955-gs65c3fy	158	13	infections	infection	NNS
cord-312955-gs65c3fy	158	14	,	,	,
cord-312955-gs65c3fy	158	15	the	the	DT
cord-312955-gs65c3fy	158	16	increased	increase	VBN
cord-312955-gs65c3fy	158	17	influx	influx	NN
cord-312955-gs65c3fy	158	18	of	of	IN
cord-312955-gs65c3fy	158	19	inflammatory	inflammatory	JJ
cord-312955-gs65c3fy	158	20	cells	cell	NNS
cord-312955-gs65c3fy	158	21	is	be	VBZ
cord-312955-gs65c3fy	158	22	always	always	RB
cord-312955-gs65c3fy	158	23	observed	observe	VBN
cord-312955-gs65c3fy	158	24	.	.	.
cord-312955-gs65c3fy	159	1	In	in	IN
cord-312955-gs65c3fy	159	2	a	a	DT
cord-312955-gs65c3fy	159	3	mouse	mouse	NN
cord-312955-gs65c3fy	159	4	model	model	NN
cord-312955-gs65c3fy	159	5	of	of	IN
cord-312955-gs65c3fy	159	6	SARS	SARS	NNP
cord-312955-gs65c3fy	159	7	-	-	HYPH
cord-312955-gs65c3fy	159	8	CoV	CoV	NNP
cord-312955-gs65c3fy	159	9	infection	infection	NN
cord-312955-gs65c3fy	159	10	,	,	,
cord-312955-gs65c3fy	159	11	imbalance	imbalance	NN
cord-312955-gs65c3fy	159	12	in	in	IN
cord-312955-gs65c3fy	159	13	IFN	IFN	NNP
cord-312955-gs65c3fy	159	14	-	-	HYPH
cord-312955-gs65c3fy	159	15	I	i	NN
cord-312955-gs65c3fy	159	16	and	and	CC
cord-312955-gs65c3fy	159	17	inflammatory	inflammatory	JJ
cord-312955-gs65c3fy	159	18	cells	cell	NNS
cord-312955-gs65c3fy	159	19	were	be	VBD
cord-312955-gs65c3fy	159	20	shown	show	VBN
cord-312955-gs65c3fy	159	21	as	as	IN
cord-312955-gs65c3fy	159	22	the	the	DT
cord-312955-gs65c3fy	159	23	main	main	JJ
cord-312955-gs65c3fy	159	24	cause	cause	NN
cord-312955-gs65c3fy	159	25	of	of	IN
cord-312955-gs65c3fy	159	26	fatal	fatal	JJ
cord-312955-gs65c3fy	159	27	pneumonia	pneumonia	NN
cord-312955-gs65c3fy	159	28	(	(	-LRB-
cord-312955-gs65c3fy	159	29	65	65	CD
cord-312955-gs65c3fy	159	30	)	)	-RRB-
cord-312955-gs65c3fy	159	31	.	.	.
cord-312955-gs65c3fy	160	1	In	in	IN
cord-312955-gs65c3fy	160	2	addition	addition	NN
cord-312955-gs65c3fy	160	3	to	to	IN
cord-312955-gs65c3fy	160	4	these	these	DT
cord-312955-gs65c3fy	160	5	,	,	,
cord-312955-gs65c3fy	160	6	SARS	SARS	NNP
cord-312955-gs65c3fy	160	7	-	-	HYPH
cord-312955-gs65c3fy	160	8	CoV	CoV	NNP
cord-312955-gs65c3fy	160	9	implements	implement	VBZ
cord-312955-gs65c3fy	160	10	strategies	strategy	NNS
cord-312955-gs65c3fy	160	11	to	to	TO
cord-312955-gs65c3fy	160	12	evade	evade	VB
cord-312955-gs65c3fy	160	13	the	the	DT
cord-312955-gs65c3fy	160	14	immune	immune	JJ
cord-312955-gs65c3fy	160	15	response	response	NN
cord-312955-gs65c3fy	160	16	by	by	IN
cord-312955-gs65c3fy	160	17	antagonizing	antagonize	VBG
cord-312955-gs65c3fy	160	18	IFN	IFN	NNP
cord-312955-gs65c3fy	160	19	-	-	HYPH
cord-312955-gs65c3fy	160	20	I	-PRON-	PRP
cord-312955-gs65c3fy	160	21	induced	induce	VBD
cord-312955-gs65c3fy	160	22	signaling	signal	VBG
cord-312955-gs65c3fy	160	23	pathways	pathway	NNS
cord-312955-gs65c3fy	160	24	.	.	.
cord-312955-gs65c3fy	161	1	The	the	DT
cord-312955-gs65c3fy	161	2	ORF6	ORF6	NNP
cord-312955-gs65c3fy	161	3	protein	protein	NN
cord-312955-gs65c3fy	161	4	blocks	block	VBZ
cord-312955-gs65c3fy	161	5	the	the	DT
cord-312955-gs65c3fy	161	6	expression	expression	NN
cord-312955-gs65c3fy	161	7	of	of	IN
cord-312955-gs65c3fy	161	8	STAT1activated	stat1activated	JJ
cord-312955-gs65c3fy	161	9	genes	gene	NNS
cord-312955-gs65c3fy	161	10	(	(	-LRB-
cord-312955-gs65c3fy	161	11	66	66	CD
cord-312955-gs65c3fy	161	12	)	)	-RRB-
cord-312955-gs65c3fy	161	13	.	.	.
cord-312955-gs65c3fy	162	1	SARS	SARS	NNP
cord-312955-gs65c3fy	162	2	-	-	HYPH
cord-312955-gs65c3fy	162	3	CoV	CoV	NNP
cord-312955-gs65c3fy	162	4	and	and	CC
cord-312955-gs65c3fy	162	5	MERS	MERS	NNP
cord-312955-gs65c3fy	162	6	-	-	HYPH
cord-312955-gs65c3fy	162	7	CoV	CoV	NNP
cord-312955-gs65c3fy	162	8	encode	encode	VBP
cord-312955-gs65c3fy	162	9	papainlike	papainlike	JJ
cord-312955-gs65c3fy	162	10	protease	protease	NN
cord-312955-gs65c3fy	162	11	(	(	-LRB-
cord-312955-gs65c3fy	162	12	PLP	PLP	NNP
cord-312955-gs65c3fy	162	13	)	)	-RRB-
cord-312955-gs65c3fy	162	14	that	that	WDT
cord-312955-gs65c3fy	162	15	is	be	VBZ
cord-312955-gs65c3fy	162	16	able	able	JJ
cord-312955-gs65c3fy	162	17	to	to	TO
cord-312955-gs65c3fy	162	18	impede	impede	VB
cord-312955-gs65c3fy	162	19	the	the	DT
cord-312955-gs65c3fy	162	20	immune	immune	JJ
cord-312955-gs65c3fy	162	21	response	response	NN
cord-312955-gs65c3fy	162	22	function	function	NN
cord-312955-gs65c3fy	162	23	(	(	-LRB-
cord-312955-gs65c3fy	162	24	67	67	CD
cord-312955-gs65c3fy	162	25	)	)	-RRB-
cord-312955-gs65c3fy	162	26	.	.	.
cord-312955-gs65c3fy	163	1	In	in	IN
cord-312955-gs65c3fy	163	2	addition	addition	NN
cord-312955-gs65c3fy	163	3	,	,	,
cord-312955-gs65c3fy	163	4	SARS	SARS	NNP
cord-312955-gs65c3fy	163	5	-	-	HYPH
cord-312955-gs65c3fy	163	6	CoV	CoV	NNP
cord-312955-gs65c3fy	163	7	interacts	interact	VBZ
cord-312955-gs65c3fy	163	8	with	with	IN
cord-312955-gs65c3fy	163	9	ISG15	ISG15	NNP
cord-312955-gs65c3fy	163	10	and	and	CC
cord-312955-gs65c3fy	163	11	antagonizes	antagonize	VBZ
cord-312955-gs65c3fy	163	12	the	the	DT
cord-312955-gs65c3fy	163	13	IFN	IFN	NNP
cord-312955-gs65c3fy	163	14	-	-	HYPH
cord-312955-gs65c3fy	163	15	I	I	NNP
cord-312955-gs65c3fy	163	16	-	-	HYPH
cord-312955-gs65c3fy	163	17	mediated	mediate	VBN
cord-312955-gs65c3fy	163	18	antiviral	antiviral	JJ
cord-312955-gs65c3fy	163	19	response	response	NN
cord-312955-gs65c3fy	163	20	(	(	-LRB-
cord-312955-gs65c3fy	163	21	68	68	CD
cord-312955-gs65c3fy	163	22	)	)	-RRB-
cord-312955-gs65c3fy	163	23	.	.	.
cord-312955-gs65c3fy	164	1	The	the	DT
cord-312955-gs65c3fy	164	2	MERS	MERS	NNP
cord-312955-gs65c3fy	164	3	-	-	HYPH
cord-312955-gs65c3fy	164	4	CoV	CoV	NNP
cord-312955-gs65c3fy	164	5	ORF4b	orf4b	NN
cord-312955-gs65c3fy	164	6	antagonizes	antagonize	VBZ
cord-312955-gs65c3fy	164	7	the	the	DT
cord-312955-gs65c3fy	164	8	antiviral	antiviral	JJ
cord-312955-gs65c3fy	164	9	IFNb	IFNb	NNS
cord-312955-gs65c3fy	164	10	production	production	NN
cord-312955-gs65c3fy	164	11	by	by	IN
cord-312955-gs65c3fy	164	12	inhibiting	inhibit	VBG
cord-312955-gs65c3fy	164	13	IRF3	IRF3	NNP
cord-312955-gs65c3fy	164	14	and	and	CC
cord-312955-gs65c3fy	164	15	IRF7	IRF7	NNP
cord-312955-gs65c3fy	164	16	(	(	-LRB-
cord-312955-gs65c3fy	164	17	69	69	CD
cord-312955-gs65c3fy	164	18	)	)	-RRB-
cord-312955-gs65c3fy	164	19	.	.	.
cord-312955-gs65c3fy	165	1	Also	also	RB
cord-312955-gs65c3fy	165	2	SARS	SARS	NNP
cord-312955-gs65c3fy	165	3	-	-	HYPH
cord-312955-gs65c3fy	165	4	CoV	CoV	NNP
cord-312955-gs65c3fy	165	5	inhibits	inhibit	VBZ
cord-312955-gs65c3fy	165	6	activation	activation	NN
cord-312955-gs65c3fy	165	7	of	of	IN
cord-312955-gs65c3fy	165	8	IRF3/7	IRF3/7	NNP
cord-312955-gs65c3fy	165	9	,	,	,
cord-312955-gs65c3fy	165	10	slowing	slow	VBG
cord-312955-gs65c3fy	165	11	IFNb	IFNb	NNS
cord-312955-gs65c3fy	165	12	production	production	NN
cord-312955-gs65c3fy	165	13	upon	upon	IN
cord-312955-gs65c3fy	165	14	infection	infection	NN
cord-312955-gs65c3fy	165	15	(	(	-LRB-
cord-312955-gs65c3fy	165	16	70	70	CD
cord-312955-gs65c3fy	165	17	)	)	-RRB-
cord-312955-gs65c3fy	165	18	.	.	.
cord-312955-gs65c3fy	166	1	While	while	IN
cord-312955-gs65c3fy	166	2	IRF3	IRF3	NNP
cord-312955-gs65c3fy	166	3	is	be	VBZ
cord-312955-gs65c3fy	166	4	expressed	express	VBN
cord-312955-gs65c3fy	166	5	in	in	IN
cord-312955-gs65c3fy	166	6	many	many	JJ
cord-312955-gs65c3fy	166	7	different	different	JJ
cord-312955-gs65c3fy	166	8	cell	cell	NN
cord-312955-gs65c3fy	166	9	types	type	NNS
cord-312955-gs65c3fy	166	10	,	,	,
cord-312955-gs65c3fy	166	11	plasmacytoid	plasmacytoid	NNP
cord-312955-gs65c3fy	166	12	dendritic	dendritic	JJ
cord-312955-gs65c3fy	166	13	cells	cell	NNS
cord-312955-gs65c3fy	166	14	are	be	VBP
cord-312955-gs65c3fy	166	15	the	the	DT
cord-312955-gs65c3fy	166	16	only	only	JJ
cord-312955-gs65c3fy	166	17	cells	cell	NNS
cord-312955-gs65c3fy	166	18	constitutively	constitutively	RB
cord-312955-gs65c3fy	166	19	expressing	express	VBG
cord-312955-gs65c3fy	166	20	IRF7	IRF7	NNP
cord-312955-gs65c3fy	166	21	(	(	-LRB-
cord-312955-gs65c3fy	166	22	47	47	CD
cord-312955-gs65c3fy	166	23	)	)	-RRB-
cord-312955-gs65c3fy	166	24	.	.	.
cord-312955-gs65c3fy	167	1	IFN	IFN	NNP
cord-312955-gs65c3fy	167	2	-	-	HYPH
cord-312955-gs65c3fy	167	3	I	I	NNP
cord-312955-gs65c3fy	167	4	treatment	treatment	NN
cord-312955-gs65c3fy	167	5	has	have	VBZ
cord-312955-gs65c3fy	167	6	been	be	VBN
cord-312955-gs65c3fy	167	7	studied	study	VBN
cord-312955-gs65c3fy	167	8	against	against	IN
cord-312955-gs65c3fy	167	9	MERS	MERS	NNP
cord-312955-gs65c3fy	167	10	-	-	HYPH
cord-312955-gs65c3fy	167	11	CoV	CoV	NNP
cord-312955-gs65c3fy	167	12	and	and	CC
cord-312955-gs65c3fy	167	13	SARS	SARS	NNP
cord-312955-gs65c3fy	167	14	-	-	HYPH
cord-312955-gs65c3fy	167	15	CoV	CoV	NNP
cord-312955-gs65c3fy	167	16	in	in	IN
cord-312955-gs65c3fy	167	17	numerous	numerous	JJ
cord-312955-gs65c3fy	167	18	experiments	experiment	NNS
cord-312955-gs65c3fy	167	19	,	,	,
cord-312955-gs65c3fy	167	20	both	both	CC
cord-312955-gs65c3fy	167	21	in	in	IN
cord-312955-gs65c3fy	167	22	vitro	vitro	FW
cord-312955-gs65c3fy	167	23	and	and	CC
cord-312955-gs65c3fy	167	24	in	in	IN
cord-312955-gs65c3fy	167	25	vivo	vivo	NN
cord-312955-gs65c3fy	167	26	,	,	,
cord-312955-gs65c3fy	167	27	and	and	CC
cord-312955-gs65c3fy	167	28	in	in	IN
cord-312955-gs65c3fy	167	29	combination	combination	NN
cord-312955-gs65c3fy	167	30	or	or	CC
cord-312955-gs65c3fy	167	31	not	not	RB
cord-312955-gs65c3fy	167	32	with	with	IN
cord-312955-gs65c3fy	167	33	lopinavir	lopinavir	NNS
cord-312955-gs65c3fy	167	34	/	/	SYM
cord-312955-gs65c3fy	167	35	ritonavir	ritonavir	NNS
cord-312955-gs65c3fy	167	36	,	,	,
cord-312955-gs65c3fy	167	37	ribavirin	ribavirin	NNS
cord-312955-gs65c3fy	167	38	,	,	,
cord-312955-gs65c3fy	167	39	remdesivir	remdesivir	NNP
cord-312955-gs65c3fy	167	40	,	,	,
cord-312955-gs65c3fy	167	41	corticosteroids	corticosteroid	NNS
cord-312955-gs65c3fy	167	42	,	,	,
cord-312955-gs65c3fy	167	43	or	or	CC
cord-312955-gs65c3fy	167	44	IFNg	IFNg	NNS
cord-312955-gs65c3fy	167	45	.	.	.
cord-312955-gs65c3fy	168	1	While	while	IN
cord-312955-gs65c3fy	168	2	IFNa	IFNa	NNS
cord-312955-gs65c3fy	168	3	and	and	CC
cord-312955-gs65c3fy	168	4	b	b	NNP
cord-312955-gs65c3fy	168	5	were	be	VBD
cord-312955-gs65c3fy	168	6	efficient	efficient	JJ
cord-312955-gs65c3fy	168	7	in	in	IN
cord-312955-gs65c3fy	168	8	vitro	vitro	FW
cord-312955-gs65c3fy	168	9	and	and	CC
cord-312955-gs65c3fy	168	10	in	in	IN
cord-312955-gs65c3fy	168	11	certain	certain	JJ
cord-312955-gs65c3fy	168	12	animal	animal	NN
cord-312955-gs65c3fy	168	13	models	model	NNS
cord-312955-gs65c3fy	168	14	,	,	,
cord-312955-gs65c3fy	168	15	their	-PRON-	PRP$
cord-312955-gs65c3fy	168	16	success	success	NN
cord-312955-gs65c3fy	168	17	in	in	IN
cord-312955-gs65c3fy	168	18	humans	human	NNS
cord-312955-gs65c3fy	168	19	was	be	VBD
cord-312955-gs65c3fy	168	20	less	less	RBR
cord-312955-gs65c3fy	168	21	convincing	convincing	JJ
cord-312955-gs65c3fy	168	22	[	[	-LRB-
cord-312955-gs65c3fy	168	23	for	for	IN
cord-312955-gs65c3fy	168	24	review	review	NN
cord-312955-gs65c3fy	168	25	see	see	VB
cord-312955-gs65c3fy	168	26	,	,	,
cord-312955-gs65c3fy	168	27	(	(	-LRB-
cord-312955-gs65c3fy	168	28	71	71	CD
cord-312955-gs65c3fy	168	29	,	,	,
cord-312955-gs65c3fy	168	30	72	72	CD
cord-312955-gs65c3fy	168	31	)	)	-RRB-
cord-312955-gs65c3fy	168	32	]	]	-RRB-
cord-312955-gs65c3fy	168	33	.	.	.
cord-312955-gs65c3fy	169	1	It	-PRON-	PRP
cord-312955-gs65c3fy	169	2	should	should	MD
cord-312955-gs65c3fy	169	3	be	be	VB
cord-312955-gs65c3fy	169	4	noted	note	VBN
cord-312955-gs65c3fy	169	5	that	that	IN
cord-312955-gs65c3fy	169	6	reduction	reduction	NN
cord-312955-gs65c3fy	169	7	in	in	IN
cord-312955-gs65c3fy	169	8	ARDS	ARDS	NNP
cord-312955-gs65c3fy	169	9	mortality	mortality	NN
cord-312955-gs65c3fy	169	10	(	(	-LRB-
cord-312955-gs65c3fy	169	11	not	not	RB
cord-312955-gs65c3fy	169	12	related	relate	VBN
cord-312955-gs65c3fy	169	13	to	to	IN
cord-312955-gs65c3fy	169	14	SARS	SARS	NNP
cord-312955-gs65c3fy	169	15	)	)	-RRB-
cord-312955-gs65c3fy	169	16	was	be	VBD
cord-312955-gs65c3fy	169	17	also	also	RB
cord-312955-gs65c3fy	169	18	found	find	VBN
cord-312955-gs65c3fy	169	19	to	to	TO
cord-312955-gs65c3fy	169	20	be	be	VB
cord-312955-gs65c3fy	169	21	at	at	IN
cord-312955-gs65c3fy	169	22	best	good	JJS
cord-312955-gs65c3fy	169	23	marginal	marginal	JJ
cord-312955-gs65c3fy	169	24	upon	upon	IN
cord-312955-gs65c3fy	169	25	treatment	treatment	NN
cord-312955-gs65c3fy	169	26	with	with	IN
cord-312955-gs65c3fy	169	27	IFN	IFN	NNP
cord-312955-gs65c3fy	170	1	-I	-I	NFP
cord-312955-gs65c3fy	170	2	(	(	-LRB-
cord-312955-gs65c3fy	170	3	73	73	CD
cord-312955-gs65c3fy	170	4	)	)	-RRB-
cord-312955-gs65c3fy	170	5	.	.	.
cord-312955-gs65c3fy	171	1	Still	still	RB
cord-312955-gs65c3fy	171	2	,	,	,
cord-312955-gs65c3fy	171	3	one	one	PRP
cord-312955-gs65c3fy	171	4	has	have	VBZ
cord-312955-gs65c3fy	171	5	to	to	TO
cord-312955-gs65c3fy	171	6	consider	consider	VB
cord-312955-gs65c3fy	171	7	that	that	IN
cord-312955-gs65c3fy	171	8	mice	mouse	NNS
cord-312955-gs65c3fy	171	9	studies	study	NNS
cord-312955-gs65c3fy	171	10	have	have	VBP
cord-312955-gs65c3fy	171	11	shown	show	VBN
cord-312955-gs65c3fy	171	12	the	the	DT
cord-312955-gs65c3fy	171	13	timing	timing	NN
cord-312955-gs65c3fy	171	14	of	of	IN
cord-312955-gs65c3fy	171	15	IFN	IFN	NNP
cord-312955-gs65c3fy	171	16	-	-	HYPH
cord-312955-gs65c3fy	171	17	I	I	NNP
cord-312955-gs65c3fy	171	18	administration	administration	NN
cord-312955-gs65c3fy	171	19	to	to	TO
cord-312955-gs65c3fy	171	20	be	be	VB
cord-312955-gs65c3fy	171	21	critical	critical	JJ
cord-312955-gs65c3fy	171	22	,	,	,
cord-312955-gs65c3fy	171	23	with	with	IN
cord-312955-gs65c3fy	171	24	positive	positive	JJ
cord-312955-gs65c3fy	171	25	effects	effect	NNS
cord-312955-gs65c3fy	171	26	being	be	VBG
cord-312955-gs65c3fy	171	27	observed	observe	VBN
cord-312955-gs65c3fy	171	28	if	if	IN
cord-312955-gs65c3fy	171	29	IFN	IFN	NNP
cord-312955-gs65c3fy	171	30	-	-	HYPH
cord-312955-gs65c3fy	171	31	I	-PRON-	PRP
cord-312955-gs65c3fy	171	32	was	be	VBD
cord-312955-gs65c3fy	171	33	administered	administer	VBN
cord-312955-gs65c3fy	171	34	shortly	shortly	RB
cord-312955-gs65c3fy	171	35	after	after	IN
cord-312955-gs65c3fy	171	36	infection	infection	NN
cord-312955-gs65c3fy	171	37	.	.	.
cord-312955-gs65c3fy	172	1	Conversely	conversely	RB
cord-312955-gs65c3fy	172	2	,	,	,
cord-312955-gs65c3fy	172	3	IFN	IFN	NNP
cord-312955-gs65c3fy	172	4	-	-	HYPH
cord-312955-gs65c3fy	172	5	I	-PRON-	PRP
cord-312955-gs65c3fy	172	6	failed	fail	VBD
cord-312955-gs65c3fy	172	7	to	to	TO
cord-312955-gs65c3fy	172	8	inhibit	inhibit	VB
cord-312955-gs65c3fy	172	9	viral	viral	JJ
cord-312955-gs65c3fy	172	10	replication	replication	NN
cord-312955-gs65c3fy	172	11	and	and	CC
cord-312955-gs65c3fy	172	12	resulted	result	VBD
cord-312955-gs65c3fy	172	13	in	in	IN
cord-312955-gs65c3fy	172	14	unwanted	unwanted	JJ
cord-312955-gs65c3fy	172	15	side	side	NN
cord-312955-gs65c3fy	172	16	-	-	HYPH
cord-312955-gs65c3fy	172	17	effects	effect	NNS
cord-312955-gs65c3fy	172	18	when	when	WRB
cord-312955-gs65c3fy	172	19	administered	administer	VBN
cord-312955-gs65c3fy	172	20	later	later	RB
cord-312955-gs65c3fy	172	21	in	in	IN
cord-312955-gs65c3fy	172	22	the	the	DT
cord-312955-gs65c3fy	172	23	disease	disease	NN
cord-312955-gs65c3fy	172	24	circle	circle	NN
cord-312955-gs65c3fy	172	25	(	(	-LRB-
cord-312955-gs65c3fy	172	26	74	74	CD
cord-312955-gs65c3fy	172	27	,	,	,
cord-312955-gs65c3fy	172	28	75	75	CD
cord-312955-gs65c3fy	172	29	)	)	-RRB-
cord-312955-gs65c3fy	172	30	.	.	.
cord-312955-gs65c3fy	173	1	These	these	DT
cord-312955-gs65c3fy	173	2	include	include	VBP
cord-312955-gs65c3fy	173	3	elevated	elevated	JJ
cord-312955-gs65c3fy	173	4	lung	lung	NN
cord-312955-gs65c3fy	173	5	cytokine	cytokine	NN
cord-312955-gs65c3fy	173	6	/	/	SYM
cord-312955-gs65c3fy	173	7	chemokine	chemokine	NN
cord-312955-gs65c3fy	173	8	levels	level	NNS
cord-312955-gs65c3fy	173	9	,	,	,
cord-312955-gs65c3fy	173	10	vascular	vascular	JJ
cord-312955-gs65c3fy	173	11	leakage	leakage	NN
cord-312955-gs65c3fy	173	12	,	,	,
cord-312955-gs65c3fy	173	13	and	and	CC
cord-312955-gs65c3fy	173	14	impaired	impaired	JJ
cord-312955-gs65c3fy	173	15	virus	virus	NN
cord-312955-gs65c3fy	173	16	-	-	HYPH
cord-312955-gs65c3fy	173	17	specific	specific	JJ
cord-312955-gs65c3fy	173	18	T	t	NN
cord-312955-gs65c3fy	173	19	cell	cell	NN
cord-312955-gs65c3fy	173	20	responses	response	NNS
cord-312955-gs65c3fy	173	21	.	.	.
cord-312955-gs65c3fy	174	1	It	-PRON-	PRP
cord-312955-gs65c3fy	174	2	is	be	VBZ
cord-312955-gs65c3fy	174	3	interesting	interesting	JJ
cord-312955-gs65c3fy	174	4	to	to	TO
cord-312955-gs65c3fy	174	5	note	note	VB
cord-312955-gs65c3fy	174	6	that	that	IN
cord-312955-gs65c3fy	174	7	a	a	DT
cord-312955-gs65c3fy	174	8	knockout	knockout	NN
cord-312955-gs65c3fy	174	9	of	of	IN
cord-312955-gs65c3fy	174	10	the	the	DT
cord-312955-gs65c3fy	174	11	IFN	IFN	NNP
cord-312955-gs65c3fy	174	12	-	-	HYPH
cord-312955-gs65c3fy	174	13	I	I	NNP
cord-312955-gs65c3fy	174	14	receptor	receptor	NN
cord-312955-gs65c3fy	174	15	in	in	IN
cord-312955-gs65c3fy	174	16	mice	mouse	NNS
cord-312955-gs65c3fy	174	17	resulted	result	VBD
cord-312955-gs65c3fy	174	18	in	in	IN
cord-312955-gs65c3fy	174	19	its	-PRON-	PRP$
cord-312955-gs65c3fy	174	20	protection	protection	NN
cord-312955-gs65c3fy	174	21	from	from	IN
cord-312955-gs65c3fy	174	22	lethal	lethal	JJ
cord-312955-gs65c3fy	174	23	SARS	SARS	NNP
cord-312955-gs65c3fy	174	24	-	-	HYPH
cord-312955-gs65c3fy	174	25	CoV	CoV	NNP
cord-312955-gs65c3fy	174	26	infection	infection	NN
cord-312955-gs65c3fy	174	27	.	.	.
cord-312955-gs65c3fy	175	1	These	these	DT
cord-312955-gs65c3fy	175	2	findings	finding	NNS
cord-312955-gs65c3fy	175	3	have	have	VBP
cord-312955-gs65c3fy	175	4	major	major	JJ
cord-312955-gs65c3fy	175	5	implications	implication	NNS
cord-312955-gs65c3fy	175	6	on	on	IN
cord-312955-gs65c3fy	175	7	how	how	WRB
cord-312955-gs65c3fy	175	8	to	to	TO
cord-312955-gs65c3fy	175	9	treat	treat	VB
cord-312955-gs65c3fy	175	10	humans	human	NNS
cord-312955-gs65c3fy	175	11	against	against	IN
cord-312955-gs65c3fy	175	12	SARS	SARS	NNP
cord-312955-gs65c3fy	175	13	and	and	CC
cord-312955-gs65c3fy	175	14	MERS	MERS	NNP
cord-312955-gs65c3fy	175	15	,	,	,
cord-312955-gs65c3fy	175	16	and	and	CC
cord-312955-gs65c3fy	175	17	could	could	MD
cord-312955-gs65c3fy	175	18	have	have	VB
cord-312955-gs65c3fy	175	19	affected	affect	VBN
cord-312955-gs65c3fy	175	20	the	the	DT
cord-312955-gs65c3fy	175	21	outcome	outcome	NN
cord-312955-gs65c3fy	175	22	of	of	IN
cord-312955-gs65c3fy	175	23	the	the	DT
cord-312955-gs65c3fy	175	24	clinical	clinical	JJ
cord-312955-gs65c3fy	175	25	studies	study	NNS
cord-312955-gs65c3fy	175	26	.	.	.
cord-312955-gs65c3fy	176	1	The	the	DT
cord-312955-gs65c3fy	176	2	COVID-19	covid-19	CD
cord-312955-gs65c3fy	176	3	pandemic	pandemic	NN
cord-312955-gs65c3fy	176	4	started	start	VBD
cord-312955-gs65c3fy	176	5	in	in	IN
cord-312955-gs65c3fy	176	6	December	December	NNP
cord-312955-gs65c3fy	176	7	2019	2019	CD
cord-312955-gs65c3fy	176	8	in	in	IN
cord-312955-gs65c3fy	176	9	Wuhan	Wuhan	NNP
cord-312955-gs65c3fy	176	10	,	,	,
cord-312955-gs65c3fy	176	11	China	China	NNP
cord-312955-gs65c3fy	176	12	.	.	.
cord-312955-gs65c3fy	177	1	By	by	IN
cord-312955-gs65c3fy	177	2	the	the	DT
cord-312955-gs65c3fy	177	3	summer	summer	NN
cord-312955-gs65c3fy	177	4	of	of	IN
cord-312955-gs65c3fy	177	5	2020	2020	CD
cord-312955-gs65c3fy	177	6	,	,	,
cord-312955-gs65c3fy	177	7	thirty	thirty	CD
cord-312955-gs65c3fy	177	8	million	million	CD
cord-312955-gs65c3fy	177	9	cases	case	NNS
cord-312955-gs65c3fy	177	10	were	be	VBD
cord-312955-gs65c3fy	177	11	reported	report	VBN
cord-312955-gs65c3fy	177	12	worldwide	worldwide	RB
cord-312955-gs65c3fy	177	13	,	,	,
cord-312955-gs65c3fy	177	14	with	with	IN
cord-312955-gs65c3fy	177	15	over	over	IN
cord-312955-gs65c3fy	177	16	900,000	900,000	CD
cord-312955-gs65c3fy	177	17	fatalities	fatality	NNS
cord-312955-gs65c3fy	177	18	.	.	.
cord-312955-gs65c3fy	178	1	As	as	IN
cord-312955-gs65c3fy	178	2	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	178	3	is	be	VBZ
cord-312955-gs65c3fy	178	4	closely	closely	RB
cord-312955-gs65c3fy	178	5	related	related	JJ
cord-312955-gs65c3fy	178	6	to	to	IN
cord-312955-gs65c3fy	178	7	the	the	DT
cord-312955-gs65c3fy	178	8	SARS	SARS	NNP
cord-312955-gs65c3fy	178	9	-	-	HYPH
cord-312955-gs65c3fy	178	10	CoV	CoV	NNP
cord-312955-gs65c3fy	178	11	virus	virus	NN
cord-312955-gs65c3fy	178	12	,	,	,
cord-312955-gs65c3fy	178	13	the	the	DT
cord-312955-gs65c3fy	178	14	interest	interest	NN
cord-312955-gs65c3fy	178	15	in	in	IN
cord-312955-gs65c3fy	178	16	the	the	DT
cord-312955-gs65c3fy	178	17	effect	effect	NN
cord-312955-gs65c3fy	178	18	of	of	IN
cord-312955-gs65c3fy	178	19	interferons	interferon	NNS
cord-312955-gs65c3fy	178	20	on	on	IN
cord-312955-gs65c3fy	178	21	its	-PRON-	PRP$
cord-312955-gs65c3fy	178	22	disease	disease	NN
cord-312955-gs65c3fy	178	23	progression	progression	NN
cord-312955-gs65c3fy	178	24	,	,	,
cord-312955-gs65c3fy	178	25	and	and	CC
cord-312955-gs65c3fy	178	26	its	-PRON-	PRP$
cord-312955-gs65c3fy	178	27	potential	potential	NN
cord-312955-gs65c3fy	178	28	as	as	IN
cord-312955-gs65c3fy	178	29	a	a	DT
cord-312955-gs65c3fy	178	30	drug	drug	NN
cord-312955-gs65c3fy	178	31	was	be	VBD
cord-312955-gs65c3fy	178	32	immediate	immediate	JJ
cord-312955-gs65c3fy	178	33	.	.	.
cord-312955-gs65c3fy	179	1	Disease	disease	NN
cord-312955-gs65c3fy	179	2	progression	progression	NN
cord-312955-gs65c3fy	179	3	of	of	IN
cord-312955-gs65c3fy	179	4	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	179	5	goes	go	VBZ
cord-312955-gs65c3fy	179	6	through	through	IN
cord-312955-gs65c3fy	179	7	a	a	DT
cord-312955-gs65c3fy	179	8	number	number	NN
cord-312955-gs65c3fy	179	9	of	of	IN
cord-312955-gs65c3fy	179	10	stages	stage	NNS
cord-312955-gs65c3fy	179	11	.	.	.
cord-312955-gs65c3fy	180	1	The	the	DT
cord-312955-gs65c3fy	180	2	initial	initial	JJ
cord-312955-gs65c3fy	180	3	stage	stage	NN
cord-312955-gs65c3fy	180	4	,	,	,
cord-312955-gs65c3fy	180	5	which	which	WDT
cord-312955-gs65c3fy	180	6	last	last	RB
cord-312955-gs65c3fy	180	7	from	from	IN
cord-312955-gs65c3fy	180	8	2	2	CD
cord-312955-gs65c3fy	180	9	to	to	TO
cord-312955-gs65c3fy	180	10	14	14	CD
cord-312955-gs65c3fy	180	11	days	day	NNS
cord-312955-gs65c3fy	180	12	(	(	-LRB-
cord-312955-gs65c3fy	180	13	usually	usually	RB
cord-312955-gs65c3fy	180	14	5	5	CD
cord-312955-gs65c3fy	180	15	-	-	SYM
cord-312955-gs65c3fy	180	16	6	6	CD
cord-312955-gs65c3fy	180	17	days	day	NNS
cord-312955-gs65c3fy	180	18	)	)	-RRB-
cord-312955-gs65c3fy	180	19	from	from	IN
cord-312955-gs65c3fy	180	20	infection	infection	NN
cord-312955-gs65c3fy	180	21	is	be	VBZ
cord-312955-gs65c3fy	180	22	asymptomatic	asymptomatic	JJ
cord-312955-gs65c3fy	180	23	.	.	.
cord-312955-gs65c3fy	181	1	A	a	DT
cord-312955-gs65c3fy	181	2	certain	certain	JJ
cord-312955-gs65c3fy	181	3	proportion	proportion	NN
cord-312955-gs65c3fy	181	4	of	of	IN
cord-312955-gs65c3fy	181	5	patients	patient	NNS
cord-312955-gs65c3fy	181	6	never	never	RB
cord-312955-gs65c3fy	181	7	produce	produce	VBP
cord-312955-gs65c3fy	181	8	any	any	DT
cord-312955-gs65c3fy	181	9	symptoms	symptom	NNS
cord-312955-gs65c3fy	181	10	(	(	-LRB-
cord-312955-gs65c3fy	181	11	the	the	DT
cord-312955-gs65c3fy	181	12	percentage	percentage	NN
cord-312955-gs65c3fy	181	13	of	of	IN
cord-312955-gs65c3fy	181	14	those	those	DT
cord-312955-gs65c3fy	181	15	is	be	VBZ
cord-312955-gs65c3fy	181	16	under	under	IN
cord-312955-gs65c3fy	181	17	debate	debate	NN
cord-312955-gs65c3fy	181	18	,	,	,
cord-312955-gs65c3fy	181	19	but	but	CC
cord-312955-gs65c3fy	181	20	a	a	DT
cord-312955-gs65c3fy	181	21	range	range	NN
cord-312955-gs65c3fy	181	22	of	of	IN
cord-312955-gs65c3fy	181	23	30	30	CD
cord-312955-gs65c3fy	181	24	-	-	SYM
cord-312955-gs65c3fy	181	25	50	50	CD
cord-312955-gs65c3fy	181	26	%	%	NN
cord-312955-gs65c3fy	181	27	is	be	VBZ
cord-312955-gs65c3fy	181	28	most	most	RBS
cord-312955-gs65c3fy	181	29	likely	likely	JJ
cord-312955-gs65c3fy	181	30	)	)	-RRB-
cord-312955-gs65c3fy	181	31	.	.	.
cord-312955-gs65c3fy	182	1	Of	of	IN
cord-312955-gs65c3fy	182	2	those	those	DT
cord-312955-gs65c3fy	182	3	who	who	WP
cord-312955-gs65c3fy	182	4	develop	develop	VBP
cord-312955-gs65c3fy	182	5	symptoms	symptom	NNS
cord-312955-gs65c3fy	182	6	,	,	,
cord-312955-gs65c3fy	182	7	they	-PRON-	PRP
cord-312955-gs65c3fy	182	8	are	be	VBP
cord-312955-gs65c3fy	182	9	mostly	mostly	RB
cord-312955-gs65c3fy	182	10	mild	mild	JJ
cord-312955-gs65c3fy	182	11	(	(	-LRB-
cord-312955-gs65c3fy	182	12	80	80	CD
cord-312955-gs65c3fy	182	13	%	%	NN
cord-312955-gs65c3fy	182	14	of	of	IN
cord-312955-gs65c3fy	182	15	those	those	DT
cord-312955-gs65c3fy	182	16	who	who	WP
cord-312955-gs65c3fy	182	17	develop	develop	VBP
cord-312955-gs65c3fy	182	18	symptoms	symptom	NNS
cord-312955-gs65c3fy	182	19	)	)	-RRB-
cord-312955-gs65c3fy	182	20	.	.	.
cord-312955-gs65c3fy	183	1	From	from	IN
cord-312955-gs65c3fy	183	2	the	the	DT
cord-312955-gs65c3fy	183	3	remaining	remain	VBG
cord-312955-gs65c3fy	183	4	20	20	CD
cord-312955-gs65c3fy	183	5	%	%	NN
cord-312955-gs65c3fy	183	6	,	,	,
cord-312955-gs65c3fy	183	7	about	about	IN
cord-312955-gs65c3fy	183	8	half	half	NN
cord-312955-gs65c3fy	183	9	will	will	MD
cord-312955-gs65c3fy	183	10	develop	develop	VB
cord-312955-gs65c3fy	183	11	severe	severe	JJ
cord-312955-gs65c3fy	183	12	symptoms	symptom	NNS
cord-312955-gs65c3fy	183	13	,	,	,
cord-312955-gs65c3fy	183	14	which	which	WDT
cord-312955-gs65c3fy	183	15	require	require	VBP
cord-312955-gs65c3fy	183	16	hospitalization	hospitalization	NN
cord-312955-gs65c3fy	183	17	in	in	IN
cord-312955-gs65c3fy	183	18	intensive	intensive	JJ
cord-312955-gs65c3fy	183	19	care	care	NN
cord-312955-gs65c3fy	183	20	units	unit	NNS
cord-312955-gs65c3fy	183	21	.	.	.
cord-312955-gs65c3fy	184	1	The	the	DT
cord-312955-gs65c3fy	184	2	mortality	mortality	NN
cord-312955-gs65c3fy	184	3	rate	rate	NN
cord-312955-gs65c3fy	184	4	,	,	,
cord-312955-gs65c3fy	184	5	from	from	IN
cord-312955-gs65c3fy	184	6	those	those	DT
cord-312955-gs65c3fy	184	7	developing	develop	VBG
cord-312955-gs65c3fy	184	8	symptoms	symptom	NNS
cord-312955-gs65c3fy	184	9	is	be	VBZ
cord-312955-gs65c3fy	184	10	2	2	CD
cord-312955-gs65c3fy	184	11	%	%	NN
cord-312955-gs65c3fy	184	12	to	to	TO
cord-312955-gs65c3fy	184	13	5	5	CD
cord-312955-gs65c3fy	184	14	%	%	NN
cord-312955-gs65c3fy	184	15	.	.	.
cord-312955-gs65c3fy	185	1	The	the	DT
cord-312955-gs65c3fy	185	2	numbers	number	NNS
cord-312955-gs65c3fy	185	3	given	give	VBN
cord-312955-gs65c3fy	185	4	above	above	RB
cord-312955-gs65c3fy	185	5	are	be	VBP
cord-312955-gs65c3fy	185	6	average	average	JJ
cord-312955-gs65c3fy	185	7	,	,	,
cord-312955-gs65c3fy	185	8	and	and	CC
cord-312955-gs65c3fy	185	9	change	change	VB
cord-312955-gs65c3fy	185	10	dramatically	dramatically	RB
cord-312955-gs65c3fy	185	11	with	with	IN
cord-312955-gs65c3fy	185	12	age	age	NN
cord-312955-gs65c3fy	185	13	.	.	.
cord-312955-gs65c3fy	186	1	At	at	IN
cord-312955-gs65c3fy	186	2	young	young	JJ
cord-312955-gs65c3fy	186	3	age	age	NN
cord-312955-gs65c3fy	186	4	most	most	JJS
cord-312955-gs65c3fy	186	5	of	of	IN
cord-312955-gs65c3fy	186	6	the	the	DT
cord-312955-gs65c3fy	186	7	infected	infected	JJ
cord-312955-gs65c3fy	186	8	people	people	NNS
cord-312955-gs65c3fy	186	9	will	will	MD
cord-312955-gs65c3fy	186	10	be	be	VB
cord-312955-gs65c3fy	186	11	asymptomatic	asymptomatic	JJ
cord-312955-gs65c3fy	186	12	,	,	,
cord-312955-gs65c3fy	186	13	while	while	IN
cord-312955-gs65c3fy	186	14	over	over	IN
cord-312955-gs65c3fy	186	15	the	the	DT
cord-312955-gs65c3fy	186	16	age	age	NN
cord-312955-gs65c3fy	186	17	of	of	IN
cord-312955-gs65c3fy	186	18	70	70	CD
cord-312955-gs65c3fy	186	19	about	about	RB
cord-312955-gs65c3fy	186	20	80	80	CD
cord-312955-gs65c3fy	186	21	%	%	NN
cord-312955-gs65c3fy	186	22	will	will	MD
cord-312955-gs65c3fy	186	23	have	have	VB
cord-312955-gs65c3fy	186	24	symptoms	symptom	NNS
cord-312955-gs65c3fy	186	25	.	.	.
cord-312955-gs65c3fy	187	1	Moreover	moreover	RB
cord-312955-gs65c3fy	187	2	,	,	,
cord-312955-gs65c3fy	187	3	as	as	IN
cord-312955-gs65c3fy	187	4	the	the	DT
cord-312955-gs65c3fy	187	5	age	age	NN
cord-312955-gs65c3fy	187	6	progresses	progress	VBZ
cord-312955-gs65c3fy	187	7	,	,	,
cord-312955-gs65c3fy	187	8	symptom	symptom	NN
cord-312955-gs65c3fy	187	9	severity	severity	NN
cord-312955-gs65c3fy	187	10	increases	increase	NNS
cord-312955-gs65c3fy	187	11	(	(	-LRB-
cord-312955-gs65c3fy	187	12	76	76	CD
cord-312955-gs65c3fy	187	13	)	)	-RRB-
cord-312955-gs65c3fy	187	14	.	.	.
cord-312955-gs65c3fy	188	1	The	the	DT
cord-312955-gs65c3fy	188	2	major	major	JJ
cord-312955-gs65c3fy	188	3	complication	complication	NN
cord-312955-gs65c3fy	188	4	of	of	IN
cord-312955-gs65c3fy	188	5	severe	severe	JJ
cord-312955-gs65c3fy	188	6	infection	infection	NN
cord-312955-gs65c3fy	188	7	is	be	VBZ
cord-312955-gs65c3fy	188	8	pneumonia	pneumonia	NN
cord-312955-gs65c3fy	188	9	,	,	,
cord-312955-gs65c3fy	188	10	which	which	WDT
cord-312955-gs65c3fy	188	11	can	can	MD
cord-312955-gs65c3fy	188	12	develop	develop	VB
cord-312955-gs65c3fy	188	13	into	into	IN
cord-312955-gs65c3fy	188	14	acute	acute	JJ
cord-312955-gs65c3fy	188	15	respiratory	respiratory	JJ
cord-312955-gs65c3fy	188	16	distress	distress	NN
cord-312955-gs65c3fy	188	17	syndrome	syndrome	NN
cord-312955-gs65c3fy	188	18	(	(	-LRB-
cord-312955-gs65c3fy	188	19	ARDS	ARDS	NNP
cord-312955-gs65c3fy	188	20	)	)	-RRB-
cord-312955-gs65c3fy	188	21	.	.	.
cord-312955-gs65c3fy	189	1	In	in	IN
cord-312955-gs65c3fy	189	2	addition	addition	NN
cord-312955-gs65c3fy	189	3	,	,	,
cord-312955-gs65c3fy	189	4	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	189	5	has	have	VBZ
cord-312955-gs65c3fy	189	6	been	be	VBN
cord-312955-gs65c3fy	189	7	linked	link	VBN
cord-312955-gs65c3fy	189	8	to	to	IN
cord-312955-gs65c3fy	189	9	cardiovascular	cardiovascular	JJ
cord-312955-gs65c3fy	189	10	sequelae	sequela	NNS
cord-312955-gs65c3fy	189	11	,	,	,
cord-312955-gs65c3fy	189	12	such	such	JJ
cord-312955-gs65c3fy	189	13	as	as	IN
cord-312955-gs65c3fy	189	14	myocardial	myocardial	JJ
cord-312955-gs65c3fy	189	15	injury	injury	NN
cord-312955-gs65c3fy	189	16	,	,	,
cord-312955-gs65c3fy	189	17	arrhythmias	arrhythmias	RB
cord-312955-gs65c3fy	189	18	,	,	,
cord-312955-gs65c3fy	189	19	cardiomyopathy	cardiomyopathy	NN
cord-312955-gs65c3fy	189	20	and	and	CC
cord-312955-gs65c3fy	189	21	heart	heart	NN
cord-312955-gs65c3fy	189	22	failure	failure	NN
cord-312955-gs65c3fy	189	23	,	,	,
cord-312955-gs65c3fy	189	24	acute	acute	JJ
cord-312955-gs65c3fy	189	25	kidney	kidney	NN
cord-312955-gs65c3fy	189	26	injury	injury	NN
cord-312955-gs65c3fy	189	27	,	,	,
cord-312955-gs65c3fy	189	28	neurological	neurological	JJ
cord-312955-gs65c3fy	189	29	complications	complication	NNS
cord-312955-gs65c3fy	189	30	,	,	,
cord-312955-gs65c3fy	189	31	and	and	CC
cord-312955-gs65c3fy	189	32	acute	acute	JJ
cord-312955-gs65c3fy	189	33	ischemic	ischemic	JJ
cord-312955-gs65c3fy	189	34	stroke	stroke	NN
cord-312955-gs65c3fy	189	35	(	(	-LRB-
cord-312955-gs65c3fy	189	36	28	28	CD
cord-312955-gs65c3fy	189	37	)	)	-RRB-
cord-312955-gs65c3fy	189	38	.	.	.
cord-312955-gs65c3fy	190	1	Developing	develop	VBG
cord-312955-gs65c3fy	190	2	severe	severe	JJ
cord-312955-gs65c3fy	190	3	symptoms	symptom	NNS
cord-312955-gs65c3fy	190	4	and	and	CC
cord-312955-gs65c3fy	190	5	death	death	NN
cord-312955-gs65c3fy	190	6	is	be	VBZ
cord-312955-gs65c3fy	190	7	strongly	strongly	RB
cord-312955-gs65c3fy	190	8	related	relate	VBN
cord-312955-gs65c3fy	190	9	to	to	IN
cord-312955-gs65c3fy	190	10	background	background	NN
cord-312955-gs65c3fy	190	11	conditions	condition	NNS
cord-312955-gs65c3fy	190	12	.	.	.
cord-312955-gs65c3fy	191	1	The	the	DT
cord-312955-gs65c3fy	191	2	strongest	strong	JJS
cord-312955-gs65c3fy	191	3	relation	relation	NN
cord-312955-gs65c3fy	191	4	is	be	VBZ
cord-312955-gs65c3fy	191	5	to	to	IN
cord-312955-gs65c3fy	191	6	age	age	NN
cord-312955-gs65c3fy	191	7	,	,	,
cord-312955-gs65c3fy	191	8	with	with	IN
cord-312955-gs65c3fy	191	9	the	the	DT
cord-312955-gs65c3fy	191	10	risk	risk	NN
cord-312955-gs65c3fy	191	11	to	to	IN
cord-312955-gs65c3fy	191	12	people	people	NNS
cord-312955-gs65c3fy	191	13	under	under	IN
cord-312955-gs65c3fy	191	14	50	50	CD
cord-312955-gs65c3fy	191	15	being	be	VBG
cord-312955-gs65c3fy	191	16	very	very	RB
cord-312955-gs65c3fy	191	17	small	small	JJ
cord-312955-gs65c3fy	191	18	,	,	,
cord-312955-gs65c3fy	191	19	while	while	IN
cord-312955-gs65c3fy	191	20	the	the	DT
cord-312955-gs65c3fy	191	21	risk	risk	NN
cord-312955-gs65c3fy	191	22	peaks	peak	NNS
cord-312955-gs65c3fy	191	23	for	for	IN
cord-312955-gs65c3fy	191	24	people	people	NNS
cord-312955-gs65c3fy	191	25	over	over	IN
cord-312955-gs65c3fy	191	26	the	the	DT
cord-312955-gs65c3fy	191	27	age	age	NN
cord-312955-gs65c3fy	191	28	of	of	IN
cord-312955-gs65c3fy	191	29	75	75	CD
cord-312955-gs65c3fy	191	30	.	.	.
cord-312955-gs65c3fy	192	1	In	in	IN
cord-312955-gs65c3fy	192	2	addition	addition	NN
cord-312955-gs65c3fy	192	3	,	,	,
cord-312955-gs65c3fy	192	4	chronic	chronic	JJ
cord-312955-gs65c3fy	192	5	kidney	kidney	NN
cord-312955-gs65c3fy	192	6	disease	disease	NN
cord-312955-gs65c3fy	192	7	,	,	,
cord-312955-gs65c3fy	192	8	chronic	chronic	JJ
cord-312955-gs65c3fy	192	9	obstructive	obstructive	JJ
cord-312955-gs65c3fy	192	10	pulmonary	pulmonary	JJ
cord-312955-gs65c3fy	192	11	disease	disease	NN
cord-312955-gs65c3fy	192	12	,	,	,
cord-312955-gs65c3fy	192	13	immunocompromised	immunocompromised	JJ
cord-312955-gs65c3fy	192	14	state	state	NN
cord-312955-gs65c3fy	192	15	,	,	,
cord-312955-gs65c3fy	192	16	obesity	obesity	NN
cord-312955-gs65c3fy	192	17	,	,	,
cord-312955-gs65c3fy	192	18	heart	heart	NN
cord-312955-gs65c3fy	192	19	conditions	condition	NNS
cord-312955-gs65c3fy	192	20	and	and	CC
cord-312955-gs65c3fy	192	21	type	type	NN
cord-312955-gs65c3fy	192	22	2	2	CD
cord-312955-gs65c3fy	192	23	diabetes	diabete	NNS
cord-312955-gs65c3fy	192	24	are	be	VBP
cord-312955-gs65c3fy	192	25	linked	link	VBN
cord-312955-gs65c3fy	192	26	to	to	IN
cord-312955-gs65c3fy	192	27	higher	high	JJR
cord-312955-gs65c3fy	192	28	incidents	incident	NNS
cord-312955-gs65c3fy	192	29	of	of	IN
cord-312955-gs65c3fy	192	30	sever	sever	NN
cord-312955-gs65c3fy	192	31	disease	disease	NN
cord-312955-gs65c3fy	192	32	(	(	-LRB-
cord-312955-gs65c3fy	192	33	76	76	CD
cord-312955-gs65c3fy	192	34	)	)	-RRB-
cord-312955-gs65c3fy	192	35	.	.	.
cord-312955-gs65c3fy	193	1	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	193	2	is	be	VBZ
cord-312955-gs65c3fy	193	3	presumed	presume	VBN
cord-312955-gs65c3fy	193	4	to	to	TO
cord-312955-gs65c3fy	193	5	infect	infect	VB
cord-312955-gs65c3fy	193	6	people	people	NNS
cord-312955-gs65c3fy	193	7	mostly	mostly	RB
cord-312955-gs65c3fy	193	8	though	though	IN
cord-312955-gs65c3fy	193	9	inhalation	inhalation	NN
cord-312955-gs65c3fy	193	10	of	of	IN
cord-312955-gs65c3fy	193	11	viral	viral	JJ
cord-312955-gs65c3fy	193	12	particles	particle	NNS
cord-312955-gs65c3fy	193	13	,	,	,
cord-312955-gs65c3fy	193	14	which	which	WDT
cord-312955-gs65c3fy	193	15	can	can	MD
cord-312955-gs65c3fy	193	16	be	be	VB
cord-312955-gs65c3fy	193	17	airborne	airborne	JJ
cord-312955-gs65c3fy	193	18	,	,	,
cord-312955-gs65c3fy	193	19	in	in	IN
cord-312955-gs65c3fy	193	20	droplets	droplet	NNS
cord-312955-gs65c3fy	193	21	or	or	CC
cord-312955-gs65c3fy	193	22	otherwise	otherwise	RB
cord-312955-gs65c3fy	193	23	through	through	IN
cord-312955-gs65c3fy	193	24	infection	infection	NN
cord-312955-gs65c3fy	193	25	through	through	IN
cord-312955-gs65c3fy	193	26	touching	touch	VBG
cord-312955-gs65c3fy	193	27	infected	infected	JJ
cord-312955-gs65c3fy	193	28	surfaces	surface	NNS
cord-312955-gs65c3fy	193	29	.	.	.
cord-312955-gs65c3fy	194	1	The	the	DT
cord-312955-gs65c3fy	194	2	Spike	Spike	NNP
cord-312955-gs65c3fy	194	3	protein	protein	NN
cord-312955-gs65c3fy	194	4	on	on	IN
cord-312955-gs65c3fy	194	5	the	the	DT
cord-312955-gs65c3fy	194	6	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	194	7	surface	surface	NN
cord-312955-gs65c3fy	194	8	binds	bind	VBZ
cord-312955-gs65c3fy	194	9	to	to	IN
cord-312955-gs65c3fy	194	10	the	the	DT
cord-312955-gs65c3fy	194	11	human	human	JJ
cord-312955-gs65c3fy	194	12	ACE2	ACE2	NNP
cord-312955-gs65c3fy	194	13	protein	protein	NN
cord-312955-gs65c3fy	194	14	,	,	,
cord-312955-gs65c3fy	194	15	which	which	WDT
cord-312955-gs65c3fy	194	16	serves	serve	VBZ
cord-312955-gs65c3fy	194	17	as	as	IN
cord-312955-gs65c3fy	194	18	its	-PRON-	PRP$
cord-312955-gs65c3fy	194	19	receptor	receptor	NN
cord-312955-gs65c3fy	194	20	(	(	-LRB-
cord-312955-gs65c3fy	194	21	Figure	figure	NN
cord-312955-gs65c3fy	194	22	4	4	CD
cord-312955-gs65c3fy	194	23	)	)	-RRB-
cord-312955-gs65c3fy	194	24	.	.	.
cord-312955-gs65c3fy	195	1	The	the	DT
cord-312955-gs65c3fy	195	2	homotrimeric	homotrimeric	JJ
cord-312955-gs65c3fy	195	3	spike	spike	NN
cord-312955-gs65c3fy	195	4	glycoprotein	glycoprotein	NN
cord-312955-gs65c3fy	195	5	is	be	VBZ
cord-312955-gs65c3fy	195	6	made	make	VBN
cord-312955-gs65c3fy	195	7	from	from	IN
cord-312955-gs65c3fy	195	8	S1	S1	NNP
cord-312955-gs65c3fy	195	9	and	and	CC
cord-312955-gs65c3fy	195	10	S2	S2	NNP
cord-312955-gs65c3fy	195	11	subunits	subunit	NNS
cord-312955-gs65c3fy	195	12	.	.	.
cord-312955-gs65c3fy	196	1	Its	-PRON-	PRP$
cord-312955-gs65c3fy	196	2	binding	binding	JJ
cord-312955-gs65c3fy	196	3	and	and	CC
cord-312955-gs65c3fy	196	4	subsequent	subsequent	JJ
cord-312955-gs65c3fy	196	5	cleavage	cleavage	NN
cord-312955-gs65c3fy	196	6	by	by	IN
cord-312955-gs65c3fy	196	7	the	the	DT
cord-312955-gs65c3fy	196	8	host	host	NN
cord-312955-gs65c3fy	196	9	protease	protease	NN
cord-312955-gs65c3fy	196	10	TMPRSS2	TMPRSS2	NNP
cord-312955-gs65c3fy	196	11	results	result	NNS
cord-312955-gs65c3fy	196	12	in	in	IN
cord-312955-gs65c3fy	196	13	the	the	DT
cord-312955-gs65c3fy	196	14	fusion	fusion	NN
cord-312955-gs65c3fy	196	15	between	between	IN
cord-312955-gs65c3fy	196	16	cell	cell	NN
cord-312955-gs65c3fy	196	17	and	and	CC
cord-312955-gs65c3fy	196	18	viral	viral	JJ
cord-312955-gs65c3fy	196	19	membranes	membrane	NNS
cord-312955-gs65c3fy	196	20	and	and	CC
cord-312955-gs65c3fy	196	21	cell	cell	NN
cord-312955-gs65c3fy	196	22	entry	entry	NN
cord-312955-gs65c3fy	196	23	(	(	-LRB-
cord-312955-gs65c3fy	196	24	77	77	CD
cord-312955-gs65c3fy	196	25	)	)	-RRB-
cord-312955-gs65c3fy	196	26	.	.	.
cord-312955-gs65c3fy	197	1	Blocking	block	VBG
cord-312955-gs65c3fy	197	2	the	the	DT
cord-312955-gs65c3fy	197	3	ACE2	ACE2	NNP
cord-312955-gs65c3fy	197	4	receptors	receptor	NNS
cord-312955-gs65c3fy	197	5	by	by	IN
cord-312955-gs65c3fy	197	6	specific	specific	JJ
cord-312955-gs65c3fy	197	7	antibodies	antibody	NNS
cord-312955-gs65c3fy	197	8	voids	void	VBZ
cord-312955-gs65c3fy	197	9	viral	viral	JJ
cord-312955-gs65c3fy	197	10	entry	entry	NN
cord-312955-gs65c3fy	197	11	(	(	-LRB-
cord-312955-gs65c3fy	197	12	77	77	CD
cord-312955-gs65c3fy	197	13	)	)	-RRB-
cord-312955-gs65c3fy	197	14	(	(	-LRB-
cord-312955-gs65c3fy	197	15	78	78	CD
cord-312955-gs65c3fy	197	16	)	)	-RRB-
cord-312955-gs65c3fy	197	17	(	(	-LRB-
cord-312955-gs65c3fy	197	18	79	79	CD
cord-312955-gs65c3fy	197	19	)	)	-RRB-
cord-312955-gs65c3fy	197	20	.	.	.
cord-312955-gs65c3fy	198	1	Interestingly	interestingly	RB
cord-312955-gs65c3fy	198	2	,	,	,
cord-312955-gs65c3fy	198	3	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	198	4	receptor	receptor	NN
cord-312955-gs65c3fy	198	5	-	-	HYPH
cord-312955-gs65c3fy	198	6	binding	bind	VBG
cord-312955-gs65c3fy	198	7	domain	domain	NN
cord-312955-gs65c3fy	198	8	(	(	-LRB-
cord-312955-gs65c3fy	198	9	RBD	RBD	NNP
cord-312955-gs65c3fy	198	10	)	)	-RRB-
cord-312955-gs65c3fy	198	11	exhibited	exhibit	VBD
cord-312955-gs65c3fy	198	12	significantly	significantly	RB
cord-312955-gs65c3fy	198	13	higher	high	JJR
cord-312955-gs65c3fy	198	14	binding	bind	VBG
cord-312955-gs65c3fy	198	15	affinity	affinity	NN
cord-312955-gs65c3fy	198	16	to	to	IN
cord-312955-gs65c3fy	198	17	ACE2	ACE2	NNP
cord-312955-gs65c3fy	198	18	than	than	IN
cord-312955-gs65c3fy	198	19	the	the	DT
cord-312955-gs65c3fy	198	20	SARS	SARS	NNP
cord-312955-gs65c3fy	198	21	-	-	HYPH
cord-312955-gs65c3fy	198	22	CoV	cov	NN
cord-312955-gs65c3fy	198	23	RBD	RBD	NNP
cord-312955-gs65c3fy	198	24	,	,	,
cord-312955-gs65c3fy	198	25	which	which	WDT
cord-312955-gs65c3fy	198	26	was	be	VBD
cord-312955-gs65c3fy	198	27	speculated	speculate	VBN
cord-312955-gs65c3fy	198	28	to	to	TO
cord-312955-gs65c3fy	198	29	relate	relate	VB
cord-312955-gs65c3fy	198	30	to	to	IN
cord-312955-gs65c3fy	198	31	the	the	DT
cord-312955-gs65c3fy	198	32	higher	high	JJR
cord-312955-gs65c3fy	198	33	infectivity	infectivity	NN
cord-312955-gs65c3fy	198	34	of	of	IN
cord-312955-gs65c3fy	198	35	COVID-19	covid-19	NN
cord-312955-gs65c3fy	198	36	in	in	IN
cord-312955-gs65c3fy	198	37	relation	relation	NN
cord-312955-gs65c3fy	198	38	to	to	IN
cord-312955-gs65c3fy	198	39	SARS	SARS	NNP
cord-312955-gs65c3fy	198	40	.	.	.
cord-312955-gs65c3fy	199	1	After	after	IN
cord-312955-gs65c3fy	199	2	membrane	membrane	NN
cord-312955-gs65c3fy	199	3	fusion	fusion	NN
cord-312955-gs65c3fy	199	4	,	,	,
cord-312955-gs65c3fy	199	5	the	the	DT
cord-312955-gs65c3fy	199	6	virus	virus	NN
cord-312955-gs65c3fy	199	7	enters	enter	VBZ
cord-312955-gs65c3fy	199	8	through	through	IN
cord-312955-gs65c3fy	199	9	the	the	DT
cord-312955-gs65c3fy	199	10	endosomal	endosomal	NNP
cord-312955-gs65c3fy	199	11	pathway	pathway	NN
cord-312955-gs65c3fy	199	12	and	and	CC
cord-312955-gs65c3fy	199	13	the	the	DT
cord-312955-gs65c3fy	199	14	viral	viral	JJ
cord-312955-gs65c3fy	199	15	RNA	RNA	NNP
cord-312955-gs65c3fy	199	16	is	be	VBZ
cord-312955-gs65c3fy	199	17	released	release	VBN
cord-312955-gs65c3fy	199	18	into	into	IN
cord-312955-gs65c3fy	199	19	the	the	DT
cord-312955-gs65c3fy	199	20	host	host	NN
cord-312955-gs65c3fy	199	21	cell	cell	NN
cord-312955-gs65c3fy	199	22	.	.	.
cord-312955-gs65c3fy	200	1	The	the	DT
cord-312955-gs65c3fy	200	2	viral	viral	JJ
cord-312955-gs65c3fy	200	3	RNA	RNA	NNP
cord-312955-gs65c3fy	200	4	is	be	VBZ
cord-312955-gs65c3fy	200	5	then	then	RB
cord-312955-gs65c3fy	200	6	translated	translate	VBN
cord-312955-gs65c3fy	200	7	into	into	IN
cord-312955-gs65c3fy	200	8	viral	viral	JJ
cord-312955-gs65c3fy	200	9	polyproteins	polyprotein	NNS
cord-312955-gs65c3fy	200	10	,	,	,
cord-312955-gs65c3fy	200	11	which	which	WDT
cord-312955-gs65c3fy	200	12	are	be	VBP
cord-312955-gs65c3fy	200	13	cleaved	cleave	VBN
cord-312955-gs65c3fy	200	14	into	into	IN
cord-312955-gs65c3fy	200	15	small	small	JJ
cord-312955-gs65c3fy	200	16	products	product	NNS
cord-312955-gs65c3fy	200	17	by	by	IN
cord-312955-gs65c3fy	200	18	viral	viral	JJ
cord-312955-gs65c3fy	200	19	proteases	protease	NNS
cord-312955-gs65c3fy	200	20	(	(	-LRB-
cord-312955-gs65c3fy	200	21	papain	papain	NN
cord-312955-gs65c3fy	200	22	-	-	HYPH
cord-312955-gs65c3fy	200	23	like	like	JJ
cord-312955-gs65c3fy	200	24	protease	protease	NN
cord-312955-gs65c3fy	200	25	[	[	-LRB-
cord-312955-gs65c3fy	200	26	Plpro	Plpro	NNP
cord-312955-gs65c3fy	200	27	]	]	-RRB-
cord-312955-gs65c3fy	200	28	and	and	CC
cord-312955-gs65c3fy	200	29	the	the	DT
cord-312955-gs65c3fy	200	30	main	main	JJ
cord-312955-gs65c3fy	200	31	protease	protease	NN
cord-312955-gs65c3fy	200	32	[	[	-LRB-
cord-312955-gs65c3fy	200	33	Mpro	Mpro	NNP
cord-312955-gs65c3fy	200	34	]	]	-RRB-
cord-312955-gs65c3fy	200	35	)	)	-RRB-
cord-312955-gs65c3fy	200	36	.	.	.
cord-312955-gs65c3fy	201	1	Viral	viral	JJ
cord-312955-gs65c3fy	201	2	proteins	protein	NNS
cord-312955-gs65c3fy	201	3	and	and	CC
cord-312955-gs65c3fy	201	4	genome	genome	NN
cord-312955-gs65c3fy	201	5	RNA	RNA	NNP
cord-312955-gs65c3fy	201	6	are	be	VBP
cord-312955-gs65c3fy	201	7	subsequently	subsequently	RB
cord-312955-gs65c3fy	201	8	assembled	assemble	VBN
cord-312955-gs65c3fy	201	9	into	into	IN
cord-312955-gs65c3fy	201	10	virions	virion	NNS
cord-312955-gs65c3fy	201	11	in	in	IN
cord-312955-gs65c3fy	201	12	the	the	DT
cord-312955-gs65c3fy	201	13	ER	ER	NNP
cord-312955-gs65c3fy	201	14	and	and	CC
cord-312955-gs65c3fy	201	15	Golgi	Golgi	NNP
cord-312955-gs65c3fy	201	16	and	and	CC
cord-312955-gs65c3fy	201	17	then	then	RB
cord-312955-gs65c3fy	201	18	transported	transport	VBD
cord-312955-gs65c3fy	201	19	and	and	CC
cord-312955-gs65c3fy	201	20	released	release	VBN
cord-312955-gs65c3fy	201	21	out	out	IN
cord-312955-gs65c3fy	201	22	of	of	IN
cord-312955-gs65c3fy	201	23	the	the	DT
cord-312955-gs65c3fy	201	24	cell	cell	NN
cord-312955-gs65c3fy	201	25	.	.	.
cord-312955-gs65c3fy	202	1	The	the	DT
cord-312955-gs65c3fy	202	2	exact	exact	JJ
cord-312955-gs65c3fy	202	3	mechanism	mechanism	NN
cord-312955-gs65c3fy	202	4	of	of	IN
cord-312955-gs65c3fy	202	5	viral	viral	JJ
cord-312955-gs65c3fy	202	6	self	self	NN
cord-312955-gs65c3fy	202	7	-	-	HYPH
cord-312955-gs65c3fy	202	8	assembly	assembly	NN
cord-312955-gs65c3fy	202	9	is	be	VBZ
cord-312955-gs65c3fy	202	10	still	still	RB
cord-312955-gs65c3fy	202	11	under	under	IN
cord-312955-gs65c3fy	202	12	intense	intense	JJ
cord-312955-gs65c3fy	202	13	investigation	investigation	NN
cord-312955-gs65c3fy	202	14	(	(	-LRB-
cord-312955-gs65c3fy	202	15	80	80	CD
cord-312955-gs65c3fy	202	16	,	,	,
cord-312955-gs65c3fy	202	17	81	81	CD
cord-312955-gs65c3fy	202	18	)	)	-RRB-
cord-312955-gs65c3fy	202	19	.	.	.
cord-312955-gs65c3fy	203	1	Investigating	investigate	VBG
cord-312955-gs65c3fy	203	2	ACE2	ACE2	NNP
cord-312955-gs65c3fy	203	3	and	and	CC
cord-312955-gs65c3fy	203	4	the	the	DT
cord-312955-gs65c3fy	203	5	viral	viral	JJ
cord-312955-gs65c3fy	203	6	entry	entry	NN
cord-312955-gs65c3fy	203	7	-	-	HYPH
cord-312955-gs65c3fy	203	8	associated	associate	VBN
cord-312955-gs65c3fy	203	9	protease	protease	NN
cord-312955-gs65c3fy	203	10	TMPRSS2	TMPRSS2	NNP
cord-312955-gs65c3fy	203	11	expression	expression	NN
cord-312955-gs65c3fy	203	12	levels	level	NNS
cord-312955-gs65c3fy	203	13	in	in	IN
cord-312955-gs65c3fy	203	14	lung	lung	NN
cord-312955-gs65c3fy	203	15	tissue	tissue	NN
cord-312955-gs65c3fy	203	16	and	and	CC
cord-312955-gs65c3fy	203	17	trachea	trachea	NN
cord-312955-gs65c3fy	203	18	has	have	VBZ
cord-312955-gs65c3fy	203	19	shown	show	VBN
cord-312955-gs65c3fy	203	20	that	that	IN
cord-312955-gs65c3fy	203	21	TMPRSS2	TMPRSS2	NNP
cord-312955-gs65c3fy	203	22	is	be	VBZ
cord-312955-gs65c3fy	203	23	expressed	express	VBN
cord-312955-gs65c3fy	203	24	in	in	IN
cord-312955-gs65c3fy	203	25	both	both	DT
cord-312955-gs65c3fy	203	26	tissues	tissue	NNS
cord-312955-gs65c3fy	203	27	,	,	,
cord-312955-gs65c3fy	203	28	while	while	IN
cord-312955-gs65c3fy	203	29	ACE2	ACE2	NNP
cord-312955-gs65c3fy	203	30	is	be	VBZ
cord-312955-gs65c3fy	203	31	predominantly	predominantly	RB
cord-312955-gs65c3fy	203	32	expressed	express	VBN
cord-312955-gs65c3fy	203	33	in	in	IN
cord-312955-gs65c3fy	203	34	a	a	DT
cord-312955-gs65c3fy	203	35	transient	transient	JJ
cord-312955-gs65c3fy	203	36	secretory	secretory	JJ
cord-312955-gs65c3fy	203	37	cell	cell	NN
cord-312955-gs65c3fy	203	38	type	type	NN
cord-312955-gs65c3fy	203	39	(	(	-LRB-
cord-312955-gs65c3fy	203	40	82	82	CD
cord-312955-gs65c3fy	203	41	)	)	-RRB-
cord-312955-gs65c3fy	203	42	.	.	.
cord-312955-gs65c3fy	204	1	In	in	IN
cord-312955-gs65c3fy	204	2	addition	addition	NN
cord-312955-gs65c3fy	204	3	,	,	,
cord-312955-gs65c3fy	204	4	ACE2	ACE2	NNP
cord-312955-gs65c3fy	204	5	and	and	CC
cord-312955-gs65c3fy	204	6	TMPRSS2	TMPRSS2	NNP
cord-312955-gs65c3fy	204	7	co	co	NN
cord-312955-gs65c3fy	204	8	-	-	JJ
cord-312955-gs65c3fy	204	9	expressing	express	VBG
cord-312955-gs65c3fy	204	10	cells	cell	NNS
cord-312955-gs65c3fy	204	11	were	be	VBD
cord-312955-gs65c3fy	204	12	found	find	VBN
cord-312955-gs65c3fy	204	13	within	within	IN
cord-312955-gs65c3fy	204	14	lung	lung	NN
cord-312955-gs65c3fy	204	15	type	type	NN
cord-312955-gs65c3fy	204	16	II	II	NNP
cord-312955-gs65c3fy	204	17	alveolar	alveolar	NN
cord-312955-gs65c3fy	204	18	cells	cell	NNS
cord-312955-gs65c3fy	204	19	(	(	-LRB-
cord-312955-gs65c3fy	204	20	which	which	WDT
cord-312955-gs65c3fy	204	21	also	also	RB
cord-312955-gs65c3fy	204	22	release	release	VBP
cord-312955-gs65c3fy	204	23	pulmonary	pulmonary	JJ
cord-312955-gs65c3fy	204	24	surfactant	surfactant	NN
cord-312955-gs65c3fy	204	25	)	)	-RRB-
cord-312955-gs65c3fy	204	26	,	,	,
cord-312955-gs65c3fy	204	27	enterocytes	enterocyte	NNS
cord-312955-gs65c3fy	204	28	,	,	,
cord-312955-gs65c3fy	204	29	and	and	CC
cord-312955-gs65c3fy	204	30	nasal	nasal	JJ
cord-312955-gs65c3fy	204	31	goblet	goblet	NN
cord-312955-gs65c3fy	204	32	secretory	secretory	NN
cord-312955-gs65c3fy	204	33	cells	cell	NNS
cord-312955-gs65c3fy	204	34	(	(	-LRB-
cord-312955-gs65c3fy	204	35	83	83	CD
cord-312955-gs65c3fy	204	36	)	)	-RRB-
cord-312955-gs65c3fy	204	37	.	.	.
cord-312955-gs65c3fy	205	1	Using	use	VBG
cord-312955-gs65c3fy	205	2	single	single	JJ
cord-312955-gs65c3fy	205	3	-	-	HYPH
cord-312955-gs65c3fy	205	4	cell	cell	NN
cord-312955-gs65c3fy	205	5	RNA	rna	NN
cord-312955-gs65c3fy	205	6	-	-	HYPH
cord-312955-gs65c3fy	205	7	sequencing	sequencing	NN
cord-312955-gs65c3fy	205	8	,	,	,
cord-312955-gs65c3fy	205	9	ACE2	ACE2	NNP
cord-312955-gs65c3fy	205	10	and	and	CC
cord-312955-gs65c3fy	205	11	TMPRSS2	TMPRSS2	NNP
cord-312955-gs65c3fy	205	12	were	be	VBD
cord-312955-gs65c3fy	205	13	found	find	VBN
cord-312955-gs65c3fy	205	14	to	to	TO
cord-312955-gs65c3fy	205	15	be	be	VB
cord-312955-gs65c3fy	205	16	highly	highly	RB
cord-312955-gs65c3fy	205	17	expressed	express	VBN
cord-312955-gs65c3fy	205	18	also	also	RB
cord-312955-gs65c3fy	205	19	in	in	IN
cord-312955-gs65c3fy	205	20	the	the	DT
cord-312955-gs65c3fy	205	21	nasal	nasal	NN
cord-312955-gs65c3fy	205	22	goblet	goblet	NN
cord-312955-gs65c3fy	205	23	and	and	CC
cord-312955-gs65c3fy	205	24	ciliated	ciliated	JJ
cord-312955-gs65c3fy	205	25	cells	cell	NNS
cord-312955-gs65c3fy	205	26	(	(	-LRB-
cord-312955-gs65c3fy	205	27	84	84	CD
cord-312955-gs65c3fy	205	28	)	)	-RRB-
cord-312955-gs65c3fy	205	29	.	.	.
cord-312955-gs65c3fy	206	1	The	the	DT
cord-312955-gs65c3fy	206	2	inhaled	inhale	VBN
cord-312955-gs65c3fy	206	3	virus	virus	NN
cord-312955-gs65c3fy	206	4	likely	likely	RB
cord-312955-gs65c3fy	206	5	binds	bind	VBZ
cord-312955-gs65c3fy	206	6	to	to	IN
cord-312955-gs65c3fy	206	7	epithelial	epithelial	JJ
cord-312955-gs65c3fy	206	8	cells	cell	NNS
cord-312955-gs65c3fy	206	9	in	in	IN
cord-312955-gs65c3fy	206	10	the	the	DT
cord-312955-gs65c3fy	206	11	nasal	nasal	NN
cord-312955-gs65c3fy	206	12	cavity	cavity	NN
cord-312955-gs65c3fy	206	13	and	and	CC
cord-312955-gs65c3fy	206	14	starts	start	VBZ
cord-312955-gs65c3fy	206	15	replicating	replicate	VBG
cord-312955-gs65c3fy	206	16	.	.	.
cord-312955-gs65c3fy	207	1	The	the	DT
cord-312955-gs65c3fy	207	2	virus	virus	NN
cord-312955-gs65c3fy	207	3	propagates	propagate	VBZ
cord-312955-gs65c3fy	207	4	and	and	CC
cord-312955-gs65c3fy	207	5	migrates	migrate	VBZ
cord-312955-gs65c3fy	207	6	down	down	IN
cord-312955-gs65c3fy	207	7	the	the	DT
cord-312955-gs65c3fy	207	8	respiratory	respiratory	JJ
cord-312955-gs65c3fy	207	9	tract	tract	NN
cord-312955-gs65c3fy	207	10	along	along	IN
cord-312955-gs65c3fy	207	11	the	the	DT
cord-312955-gs65c3fy	207	12	conducting	conduct	VBG
cord-312955-gs65c3fy	207	13	airways	airway	NNS
cord-312955-gs65c3fy	207	14	,	,	,
cord-312955-gs65c3fy	207	15	and	and	CC
cord-312955-gs65c3fy	207	16	a	a	DT
cord-312955-gs65c3fy	207	17	more	more	RBR
cord-312955-gs65c3fy	207	18	robust	robust	JJ
cord-312955-gs65c3fy	207	19	innate	innate	JJ
cord-312955-gs65c3fy	207	20	immune	immune	JJ
cord-312955-gs65c3fy	207	21	response	response	NN
cord-312955-gs65c3fy	207	22	is	be	VBZ
cord-312955-gs65c3fy	207	23	triggered	trigger	VBN
cord-312955-gs65c3fy	207	24	.	.	.
cord-312955-gs65c3fy	208	1	For	for	IN
cord-312955-gs65c3fy	208	2	about	about	IN
cord-312955-gs65c3fy	208	3	80	80	CD
cord-312955-gs65c3fy	208	4	%	%	NN
cord-312955-gs65c3fy	208	5	of	of	IN
cord-312955-gs65c3fy	208	6	the	the	DT
cord-312955-gs65c3fy	208	7	infected	infected	JJ
cord-312955-gs65c3fy	208	8	patients	patient	NNS
cord-312955-gs65c3fy	208	9	,	,	,
cord-312955-gs65c3fy	208	10	the	the	DT
cord-312955-gs65c3fy	208	11	disease	disease	NN
cord-312955-gs65c3fy	208	12	will	will	MD
cord-312955-gs65c3fy	208	13	be	be	VB
cord-312955-gs65c3fy	208	14	mild	mild	JJ
cord-312955-gs65c3fy	208	15	and	and	CC
cord-312955-gs65c3fy	208	16	mostly	mostly	RB
cord-312955-gs65c3fy	208	17	restricted	restricted	JJ
cord-312955-gs65c3fy	208	18	to	to	IN
cord-312955-gs65c3fy	208	19	the	the	DT
cord-312955-gs65c3fy	208	20	upper	upper	JJ
cord-312955-gs65c3fy	208	21	and	and	CC
cord-312955-gs65c3fy	208	22	conducting	conduct	VBG
cord-312955-gs65c3fy	208	23	airways	airway	NNS
cord-312955-gs65c3fy	208	24	.	.	.
cord-312955-gs65c3fy	209	1	Unfortunately	unfortunately	RB
cord-312955-gs65c3fy	209	2	,	,	,
cord-312955-gs65c3fy	209	3	about	about	RB
cord-312955-gs65c3fy	209	4	20	20	CD
cord-312955-gs65c3fy	209	5	%	%	NN
cord-312955-gs65c3fy	209	6	of	of	IN
cord-312955-gs65c3fy	209	7	the	the	DT
cord-312955-gs65c3fy	209	8	infected	infected	JJ
cord-312955-gs65c3fy	209	9	patients	patient	NNS
cord-312955-gs65c3fy	209	10	will	will	MD
cord-312955-gs65c3fy	209	11	progress	progress	VB
cord-312955-gs65c3fy	209	12	to	to	IN
cord-312955-gs65c3fy	209	13	more	more	RBR
cord-312955-gs65c3fy	209	14	severe	severe	JJ
cord-312955-gs65c3fy	209	15	disease	disease	NN
cord-312955-gs65c3fy	209	16	and	and	CC
cord-312955-gs65c3fy	209	17	will	will	MD
cord-312955-gs65c3fy	209	18	develop	develop	VB
cord-312955-gs65c3fy	209	19	pulmonary	pulmonary	JJ
cord-312955-gs65c3fy	209	20	infiltrates	infiltrate	NNS
cord-312955-gs65c3fy	209	21	and	and	CC
cord-312955-gs65c3fy	209	22	some	some	DT
cord-312955-gs65c3fy	209	23	of	of	IN
cord-312955-gs65c3fy	209	24	them	-PRON-	PRP
cord-312955-gs65c3fy	209	25	will	will	MD
cord-312955-gs65c3fy	209	26	develop	develop	VB
cord-312955-gs65c3fy	209	27	ARDS	ARDS	NNP
cord-312955-gs65c3fy	209	28	(	(	-LRB-
cord-312955-gs65c3fy	209	29	85	85	CD
cord-312955-gs65c3fy	209	30	)	)	-RRB-
cord-312955-gs65c3fy	209	31	.	.	.
cord-312955-gs65c3fy	210	1	Like	like	IN
cord-312955-gs65c3fy	210	2	many	many	JJ
cord-312955-gs65c3fy	210	3	other	other	JJ
cord-312955-gs65c3fy	210	4	viruses	virus	NNS
cord-312955-gs65c3fy	210	5	,	,	,
cord-312955-gs65c3fy	210	6	also	also	RB
cord-312955-gs65c3fy	210	7	SARS	SARS	NNP
cord-312955-gs65c3fy	210	8	-	-	HYPH
cord-312955-gs65c3fy	210	9	CoV	CoV	NNP
cord-312955-gs65c3fy	210	10	and	and	CC
cord-312955-gs65c3fy	210	11	SARS	SARS	NNP
cord-312955-gs65c3fy	210	12	-	-	HYPH
cord-312955-gs65c3fy	210	13	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	210	14	have	have	VBP
cord-312955-gs65c3fy	210	15	evolved	evolve	VBN
cord-312955-gs65c3fy	210	16	mechanisms	mechanism	NNS
cord-312955-gs65c3fy	210	17	to	to	TO
cord-312955-gs65c3fy	210	18	reduce	reduce	VB
cord-312955-gs65c3fy	210	19	their	-PRON-	PRP$
cord-312955-gs65c3fy	210	20	exposure	exposure	NN
cord-312955-gs65c3fy	210	21	to	to	IN
cord-312955-gs65c3fy	210	22	IFN	IFN	NNP
cord-312955-gs65c3fy	210	23	-	-	HYPH
cord-312955-gs65c3fy	210	24	I.	I.	NNP
cord-312955-gs65c3fy	211	1	In	in	IN
cord-312955-gs65c3fy	211	2	both	both	DT
cord-312955-gs65c3fy	211	3	viruses	virus	NNS
cord-312955-gs65c3fy	211	4	,	,	,
cord-312955-gs65c3fy	211	5	mechanisms	mechanism	NNS
cord-312955-gs65c3fy	211	6	to	to	TO
cord-312955-gs65c3fy	211	7	block	block	VB
cord-312955-gs65c3fy	211	8	the	the	DT
cord-312955-gs65c3fy	211	9	production	production	NN
cord-312955-gs65c3fy	211	10	of	of	IN
cord-312955-gs65c3fy	211	11	IFNb	IFNb	NNS
cord-312955-gs65c3fy	211	12	were	be	VBD
cord-312955-gs65c3fy	211	13	identified	identify	VBN
cord-312955-gs65c3fy	211	14	.	.	.
cord-312955-gs65c3fy	212	1	While	while	IN
cord-312955-gs65c3fy	212	2	the	the	DT
cord-312955-gs65c3fy	212	3	antiviral	antiviral	JJ
cord-312955-gs65c3fy	212	4	potency	potency	NN
cord-312955-gs65c3fy	212	5	of	of	IN
cord-312955-gs65c3fy	212	6	IFN	IFN	NNP
cord-312955-gs65c3fy	212	7	-	-	,
cord-312955-gs65c3fy	212	8	Is	be	VBZ
cord-312955-gs65c3fy	212	9	on	on	IN
cord-312955-gs65c3fy	212	10	SARS	SARS	NNP
cord-312955-gs65c3fy	212	11	-	-	HYPH
cord-312955-gs65c3fy	212	12	CoV	CoV	NNP
cord-312955-gs65c3fy	212	13	is	be	VBZ
cord-312955-gs65c3fy	212	14	moderate	moderate	JJ
cord-312955-gs65c3fy	212	15	,	,	,
cord-312955-gs65c3fy	212	16	SARS	SARS	NNP
cord-312955-gs65c3fy	212	17	-	-	HYPH
cord-312955-gs65c3fy	212	18	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	212	19	seems	seem	VBZ
cord-312955-gs65c3fy	212	20	to	to	TO
cord-312955-gs65c3fy	212	21	be	be	VB
cord-312955-gs65c3fy	212	22	highly	highly	RB
cord-312955-gs65c3fy	212	23	sensitive	sensitive	JJ
cord-312955-gs65c3fy	212	24	to	to	IN
cord-312955-gs65c3fy	212	25	IFN	IFN	NNP
cord-312955-gs65c3fy	212	26	-	-	HYPH
cord-312955-gs65c3fy	212	27	I.	I.	NNP
cord-312955-gs65c3fy	213	1	This	this	DT
cord-312955-gs65c3fy	213	2	is	be	VBZ
cord-312955-gs65c3fy	213	3	evident	evident	JJ
cord-312955-gs65c3fy	213	4	by	by	IN
cord-312955-gs65c3fy	213	5	the	the	DT
cord-312955-gs65c3fy	213	6	significant	significant	JJ
cord-312955-gs65c3fy	213	7	reduction	reduction	NN
cord-312955-gs65c3fy	213	8	in	in	IN
cord-312955-gs65c3fy	213	9	viral	viral	JJ
cord-312955-gs65c3fy	213	10	replication	replication	NN
cord-312955-gs65c3fy	213	11	observed	observe	VBD
cord-312955-gs65c3fy	213	12	following	follow	VBG
cord-312955-gs65c3fy	213	13	IFN	IFN	NNP
cord-312955-gs65c3fy	213	14	-	-	HYPH
cord-312955-gs65c3fy	213	15	I	I	NNP
cord-312955-gs65c3fy	213	16	treatment	treatment	NN
cord-312955-gs65c3fy	213	17	at	at	IN
cord-312955-gs65c3fy	213	18	both	both	CC
cord-312955-gs65c3fy	213	19	24	24	CD
cord-312955-gs65c3fy	213	20	and	and	CC
cord-312955-gs65c3fy	213	21	48	48	CD
cord-312955-gs65c3fy	213	22	h	h	NN
cord-312955-gs65c3fy	213	23	postinfection	postinfection	NN
cord-312955-gs65c3fy	213	24	(	(	-LRB-
cord-312955-gs65c3fy	213	25	86	86	CD
cord-312955-gs65c3fy	213	26	)	)	-RRB-
cord-312955-gs65c3fy	213	27	.	.	.
cord-312955-gs65c3fy	214	1	In	in	IN
cord-312955-gs65c3fy	214	2	SARS	SARS	NNP
cord-312955-gs65c3fy	214	3	-	-	HYPH
cord-312955-gs65c3fy	214	4	CoV-2-infected	cov-2-infecte	VBN
cord-312955-gs65c3fy	214	5	cells	cell	NNS
cord-312955-gs65c3fy	214	6	,	,	,
cord-312955-gs65c3fy	214	7	IFN	IFN	NNP
cord-312955-gs65c3fy	214	8	-	-	HYPH
cord-312955-gs65c3fy	214	9	I	-PRON-	PRP
cord-312955-gs65c3fy	214	10	results	result	VBZ
cord-312955-gs65c3fy	214	11	in	in	IN
cord-312955-gs65c3fy	214	12	elevated	elevated	JJ
cord-312955-gs65c3fy	214	13	STAT1	stat1	NN
cord-312955-gs65c3fy	214	14	levels	level	NNS
cord-312955-gs65c3fy	214	15	and	and	CC
cord-312955-gs65c3fy	214	16	ISG	ISG	NNP
cord-312955-gs65c3fy	214	17	production	production	NN
cord-312955-gs65c3fy	214	18	(	(	-LRB-
cord-312955-gs65c3fy	214	19	in	in	IN
cord-312955-gs65c3fy	214	20	contrast	contrast	NN
cord-312955-gs65c3fy	214	21	to	to	IN
cord-312955-gs65c3fy	214	22	SARS	SARS	NNP
cord-312955-gs65c3fy	214	23	-	-	HYPH
cord-312955-gs65c3fy	214	24	CoV	CoV	NNP
cord-312955-gs65c3fy	214	25	infected	infected	JJ
cord-312955-gs65c3fy	214	26	cells	cell	NNS
cord-312955-gs65c3fy	214	27	)	)	-RRB-
cord-312955-gs65c3fy	214	28	.	.	.
cord-312955-gs65c3fy	215	1	This	this	DT
cord-312955-gs65c3fy	215	2	raises	raise	VBZ
cord-312955-gs65c3fy	215	3	the	the	DT
cord-312955-gs65c3fy	215	4	question	question	NN
cord-312955-gs65c3fy	215	5	of	of	IN
cord-312955-gs65c3fy	215	6	why	why	WRB
cord-312955-gs65c3fy	215	7	the	the	DT
cord-312955-gs65c3fy	215	8	innate	innate	JJ
cord-312955-gs65c3fy	215	9	immune	immune	JJ
cord-312955-gs65c3fy	215	10	system	system	NN
cord-312955-gs65c3fy	215	11	fails	fail	VBZ
cord-312955-gs65c3fy	215	12	to	to	TO
cord-312955-gs65c3fy	215	13	combat	combat	VB
cord-312955-gs65c3fy	215	14	SARS	SARS	NNP
cord-312955-gs65c3fy	215	15	-	-	HYPH
cord-312955-gs65c3fy	215	16	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	215	17	?	?	.
cord-312955-gs65c3fy	216	1	The	the	DT
cord-312955-gs65c3fy	216	2	apparent	apparent	JJ
cord-312955-gs65c3fy	216	3	answer	answer	NN
cord-312955-gs65c3fy	216	4	to	to	IN
cord-312955-gs65c3fy	216	5	this	this	DT
cord-312955-gs65c3fy	216	6	is	be	VBZ
cord-312955-gs65c3fy	216	7	in	in	IN
cord-312955-gs65c3fy	216	8	the	the	DT
cord-312955-gs65c3fy	216	9	inhibition	inhibition	NN
cord-312955-gs65c3fy	216	10	of	of	IN
cord-312955-gs65c3fy	216	11	IFNb	ifnb	JJ
cord-312955-gs65c3fy	216	12	production	production	NN
cord-312955-gs65c3fy	216	13	by	by	IN
cord-312955-gs65c3fy	216	14	proteins	protein	NNS
cord-312955-gs65c3fy	216	15	of	of	IN
cord-312955-gs65c3fy	216	16	the	the	DT
cord-312955-gs65c3fy	216	17	SARS	SARS	NNP
cord-312955-gs65c3fy	216	18	-	-	HYPH
cord-312955-gs65c3fy	216	19	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	216	20	virus	virus	NN
cord-312955-gs65c3fy	216	21	.	.	.
cord-312955-gs65c3fy	217	1	Within	within	IN
cord-312955-gs65c3fy	217	2	cells	cell	NNS
cord-312955-gs65c3fy	217	3	,	,	,
cord-312955-gs65c3fy	217	4	RNA	RNA	NNP
cord-312955-gs65c3fy	217	5	viruses	virus	NNS
cord-312955-gs65c3fy	217	6	are	be	VBP
cord-312955-gs65c3fy	217	7	sensed	sense	VBN
cord-312955-gs65c3fy	217	8	by	by	IN
cord-312955-gs65c3fy	217	9	the	the	DT
cord-312955-gs65c3fy	217	10	innate	innate	JJ
cord-312955-gs65c3fy	217	11	immune	immune	JJ
cord-312955-gs65c3fy	217	12	system	system	NN
cord-312955-gs65c3fy	217	13	through	through	IN
cord-312955-gs65c3fy	217	14	three	three	CD
cord-312955-gs65c3fy	217	15	major	major	JJ
cord-312955-gs65c3fy	217	16	classes	class	NNS
cord-312955-gs65c3fy	217	17	of	of	IN
cord-312955-gs65c3fy	217	18	pattern	pattern	NN
cord-312955-gs65c3fy	217	19	recognition	recognition	NN
cord-312955-gs65c3fy	217	20	receptors	receptor	NNS
cord-312955-gs65c3fy	217	21	(	(	-LRB-
cord-312955-gs65c3fy	217	22	PRRs	PRRs	NNP
cord-312955-gs65c3fy	217	23	)	)	-RRB-
cord-312955-gs65c3fy	217	24	:	:	:
cord-312955-gs65c3fy	217	25	Toll	toll	NN
cord-312955-gs65c3fy	217	26	-	-	HYPH
cord-312955-gs65c3fy	217	27	like	like	JJ
cord-312955-gs65c3fy	217	28	receptors	receptor	NNS
cord-312955-gs65c3fy	217	29	(	(	-LRB-
cord-312955-gs65c3fy	218	1	i.e.	i.e.	FW
cord-312955-gs65c3fy	218	2	TLR-3	TLR-3	NNP
cord-312955-gs65c3fy	218	3	,	,	,
cord-312955-gs65c3fy	218	4	-7	-7	NNP
cord-312955-gs65c3fy	218	5	,	,	,
cord-312955-gs65c3fy	218	6	-8	-8	ADD
cord-312955-gs65c3fy	218	7	)	)	-RRB-
cord-312955-gs65c3fy	218	8	,	,	,
cord-312955-gs65c3fy	218	9	RIG	rig	NN
cord-312955-gs65c3fy	218	10	-	-	HYPH
cord-312955-gs65c3fy	218	11	I	-PRON-	PRP
cord-312955-gs65c3fy	218	12	-	-	HYPH
cord-312955-gs65c3fy	218	13	like	like	JJ
cord-312955-gs65c3fy	218	14	receptors	receptor	NNS
cord-312955-gs65c3fy	218	15	(	(	-LRB-
cord-312955-gs65c3fy	218	16	RLRs	RLRs	NNP
cord-312955-gs65c3fy	218	17	)	)	-RRB-
cord-312955-gs65c3fy	218	18	,	,	,
cord-312955-gs65c3fy	218	19	and	and	CC
cord-312955-gs65c3fy	218	20	NOD	nod	JJ
cord-312955-gs65c3fy	218	21	-	-	HYPH
cord-312955-gs65c3fy	218	22	like	like	JJ
cord-312955-gs65c3fy	218	23	receptors	receptor	NNS
cord-312955-gs65c3fy	218	24	(	(	-LRB-
cord-312955-gs65c3fy	218	25	NLRs	NLRs	NNP
cord-312955-gs65c3fy	218	26	)	)	-RRB-
cord-312955-gs65c3fy	218	27	(	(	-LRB-
cord-312955-gs65c3fy	218	28	87	87	CD
cord-312955-gs65c3fy	218	29	)	)	-RRB-
cord-312955-gs65c3fy	218	30	.	.	.
cord-312955-gs65c3fy	219	1	To	to	TO
cord-312955-gs65c3fy	219	2	identify	identify	VB
cord-312955-gs65c3fy	219	3	the	the	DT
cord-312955-gs65c3fy	219	4	molecular	molecular	JJ
cord-312955-gs65c3fy	219	5	mechanisms	mechanism	NNS
cord-312955-gs65c3fy	219	6	that	that	WDT
cord-312955-gs65c3fy	219	7	block	block	VBP
cord-312955-gs65c3fy	219	8	IFNb	IFNb	NNS
cord-312955-gs65c3fy	219	9	production	production	NN
cord-312955-gs65c3fy	219	10	through	through	IN
cord-312955-gs65c3fy	219	11	activation	activation	NN
cord-312955-gs65c3fy	219	12	of	of	IN
cord-312955-gs65c3fy	219	13	IRF3/7	IRF3/7	NNP
cord-312955-gs65c3fy	219	14	,	,	,
cord-312955-gs65c3fy	219	15	several	several	JJ
cord-312955-gs65c3fy	219	16	research	research	NN
cord-312955-gs65c3fy	219	17	groups	group	NNS
cord-312955-gs65c3fy	219	18	transfected	transfecte	VBD
cord-312955-gs65c3fy	219	19	cells	cell	NNS
cord-312955-gs65c3fy	219	20	individually	individually	RB
cord-312955-gs65c3fy	219	21	with	with	IN
cord-312955-gs65c3fy	219	22	all	all	PDT
cord-312955-gs65c3fy	219	23	the	the	DT
cord-312955-gs65c3fy	219	24	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	219	25	viral	viral	JJ
cord-312955-gs65c3fy	219	26	genes	gene	NNS
cord-312955-gs65c3fy	219	27	and	and	CC
cord-312955-gs65c3fy	219	28	with	with	IN
cord-312955-gs65c3fy	219	29	either	either	DT
cord-312955-gs65c3fy	219	30	RIG	rig	NN
cord-312955-gs65c3fy	219	31	I	-PRON-	PRP
cord-312955-gs65c3fy	219	32	,	,	,
cord-312955-gs65c3fy	219	33	MDA5	MDA5	NNP
cord-312955-gs65c3fy	219	34	,	,	,
cord-312955-gs65c3fy	219	35	or	or	CC
cord-312955-gs65c3fy	219	36	MAVS	MAVS	NNP
cord-312955-gs65c3fy	219	37	(	(	-LRB-
cord-312955-gs65c3fy	219	38	88	88	CD
cord-312955-gs65c3fy	219	39	,	,	,
cord-312955-gs65c3fy	219	40	89	89	CD
cord-312955-gs65c3fy	219	41	)	)	-RRB-
cord-312955-gs65c3fy	219	42	.	.	.
cord-312955-gs65c3fy	220	1	Among	among	IN
cord-312955-gs65c3fy	220	2	the	the	DT
cord-312955-gs65c3fy	220	3	27	27	CD
cord-312955-gs65c3fy	220	4	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	220	5	proteins	protein	NNS
cord-312955-gs65c3fy	220	6	transfected	transfecte	VBN
cord-312955-gs65c3fy	220	7	to	to	IN
cord-312955-gs65c3fy	220	8	cells	cell	NNS
cord-312955-gs65c3fy	220	9	,	,	,
cord-312955-gs65c3fy	220	10	they	-PRON-	PRP
cord-312955-gs65c3fy	220	11	identified	identify	VBD
cord-312955-gs65c3fy	220	12	nsp14	nsp14	XX
cord-312955-gs65c3fy	220	13	and	and	CC
cord-312955-gs65c3fy	220	14	orf6	orf6	VB
cord-312955-gs65c3fy	220	15	as	as	IN
cord-312955-gs65c3fy	220	16	competent	competent	JJ
cord-312955-gs65c3fy	220	17	suppressors	suppressor	NNS
cord-312955-gs65c3fy	220	18	of	of	IN
cord-312955-gs65c3fy	220	19	IFNb	IFNb	NNS
cord-312955-gs65c3fy	220	20	.	.	.
cord-312955-gs65c3fy	221	1	Yuen	Yuen	NNP
cord-312955-gs65c3fy	221	2	et	et	NNP
cord-312955-gs65c3fy	221	3	al	al	NNP
cord-312955-gs65c3fy	221	4	.	.	.
cord-312955-gs65c3fy	222	1	also	also	RB
cord-312955-gs65c3fy	222	2	identified	identify	VBN
cord-312955-gs65c3fy	222	3	nsp13	nsp13	NNP
cord-312955-gs65c3fy	222	4	and	and	CC
cord-312955-gs65c3fy	222	5	15	15	CD
cord-312955-gs65c3fy	222	6	,	,	,
cord-312955-gs65c3fy	222	7	while	while	IN
cord-312955-gs65c3fy	222	8	Lei	Lei	NNP
cord-312955-gs65c3fy	222	9	et	et	FW
cord-312955-gs65c3fy	222	10	al	al	NNP
cord-312955-gs65c3fy	222	11	.	.	NNP
cord-312955-gs65c3fy	222	12	identified	identify	VBD
cord-312955-gs65c3fy	222	13	nsp1	nsp1	NNS
cord-312955-gs65c3fy	222	14	,	,	,
cord-312955-gs65c3fy	222	15	nsp12	nsp12	CD
cord-312955-gs65c3fy	222	16	and	and	CC
cord-312955-gs65c3fy	222	17	the	the	DT
cord-312955-gs65c3fy	222	18	M	M	NNP
cord-312955-gs65c3fy	222	19	protein	protein	NN
cord-312955-gs65c3fy	222	20	as	as	IN
cord-312955-gs65c3fy	222	21	potent	potent	JJ
cord-312955-gs65c3fy	222	22	inhibitors	inhibitor	NNS
cord-312955-gs65c3fy	222	23	of	of	IN
cord-312955-gs65c3fy	222	24	the	the	DT
cord-312955-gs65c3fy	222	25	MAVS	MAVS	NNP
cord-312955-gs65c3fy	222	26	pathway	pathway	NNP
cord-312955-gs65c3fy	222	27	,	,	,
cord-312955-gs65c3fy	222	28	leading	lead	VBG
cord-312955-gs65c3fy	222	29	to	to	IN
cord-312955-gs65c3fy	222	30	inhibition	inhibition	NN
cord-312955-gs65c3fy	222	31	of	of	IN
cord-312955-gs65c3fy	222	32	IFNb	IFNb	NNS
cord-312955-gs65c3fy	222	33	production	production	NN
cord-312955-gs65c3fy	222	34	(	(	-LRB-
cord-312955-gs65c3fy	222	35	Figure	figure	NN
cord-312955-gs65c3fy	222	36	4	4	CD
cord-312955-gs65c3fy	222	37	)	)	-RRB-
cord-312955-gs65c3fy	222	38	.	.	.
cord-312955-gs65c3fy	223	1	Orf6	Orf6	NNP
cord-312955-gs65c3fy	223	2	was	be	VBD
cord-312955-gs65c3fy	223	3	between	between	IN
cord-312955-gs65c3fy	223	4	the	the	DT
cord-312955-gs65c3fy	223	5	strongest	strong	JJS
cord-312955-gs65c3fy	223	6	suppressors	suppressor	NNS
cord-312955-gs65c3fy	223	7	of	of	IN
cord-312955-gs65c3fy	223	8	IFNb	ifnb	JJ
cord-312955-gs65c3fy	223	9	production	production	NN
cord-312955-gs65c3fy	223	10	in	in	IN
cord-312955-gs65c3fy	223	11	both	both	DT
cord-312955-gs65c3fy	223	12	studies	study	NNS
cord-312955-gs65c3fy	223	13	.	.	.
cord-312955-gs65c3fy	224	1	Orf6	Orf6	NNP
cord-312955-gs65c3fy	224	2	was	be	VBD
cord-312955-gs65c3fy	224	3	also	also	RB
cord-312955-gs65c3fy	224	4	the	the	DT
cord-312955-gs65c3fy	224	5	only	only	JJ
cord-312955-gs65c3fy	224	6	SARS	SARS	NNP
cord-312955-gs65c3fy	224	7	-	-	HYPH
cord-312955-gs65c3fy	224	8	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	224	9	gene	gene	NN
cord-312955-gs65c3fy	224	10	suppressing	suppress	VBG
cord-312955-gs65c3fy	224	11	the	the	DT
cord-312955-gs65c3fy	224	12	activity	activity	NN
cord-312955-gs65c3fy	224	13	of	of	IN
cord-312955-gs65c3fy	224	14	an	an	DT
cord-312955-gs65c3fy	224	15	interferon	interferon	NN
cord-312955-gs65c3fy	224	16	-	-	HYPH
cord-312955-gs65c3fy	224	17	stimulated	stimulate	VBN
cord-312955-gs65c3fy	224	18	response	response	NN
cord-312955-gs65c3fy	224	19	element	element	NN
cord-312955-gs65c3fy	224	20	(	(	-LRB-
cord-312955-gs65c3fy	224	21	ISRE	ISRE	NNP
cord-312955-gs65c3fy	224	22	)	)	-RRB-
cord-312955-gs65c3fy	224	23	promoter	promoter	NN
cord-312955-gs65c3fy	224	24	in	in	IN
cord-312955-gs65c3fy	224	25	both	both	DT
cord-312955-gs65c3fy	224	26	studies	study	NNS
cord-312955-gs65c3fy	224	27	.	.	.
cord-312955-gs65c3fy	225	1	Lei	Lei	NNP
cord-312955-gs65c3fy	225	2	et	et	FW
cord-312955-gs65c3fy	225	3	al	al	NNP
cord-312955-gs65c3fy	225	4	.	.	.
cord-312955-gs65c3fy	226	1	also	also	RB
cord-312955-gs65c3fy	226	2	identified	identify	VBD
cord-312955-gs65c3fy	226	3	nsp1	nsp1	NNS
cord-312955-gs65c3fy	226	4	and	and	CC
cord-312955-gs65c3fy	226	5	nsp14	nsp14	ADD
cord-312955-gs65c3fy	226	6	as	as	IN
cord-312955-gs65c3fy	226	7	potent	potent	JJ
cord-312955-gs65c3fy	226	8	inhibitors	inhibitor	NNS
cord-312955-gs65c3fy	226	9	of	of	IN
cord-312955-gs65c3fy	226	10	the	the	DT
cord-312955-gs65c3fy	226	11	induction	induction	NN
cord-312955-gs65c3fy	226	12	of	of	IN
cord-312955-gs65c3fy	226	13	an	an	DT
cord-312955-gs65c3fy	226	14	ISRE	ISRE	NNP
cord-312955-gs65c3fy	226	15	promotor	promotor	NN
cord-312955-gs65c3fy	226	16	.	.	.
cord-312955-gs65c3fy	227	1	In	in	IN
cord-312955-gs65c3fy	227	2	another	another	DT
cord-312955-gs65c3fy	227	3	study	study	NN
cord-312955-gs65c3fy	227	4	,	,	,
cord-312955-gs65c3fy	227	5	Li	Li	NNP
cord-312955-gs65c3fy	227	6	et	et	NNP
cord-312955-gs65c3fy	227	7	al	al	NNP
cord-312955-gs65c3fy	227	8	.	.	NNP
cord-312955-gs65c3fy	227	9	showed	show	VBD
cord-312955-gs65c3fy	227	10	that	that	IN
cord-312955-gs65c3fy	227	11	the	the	DT
cord-312955-gs65c3fy	227	12	viral	viral	JJ
cord-312955-gs65c3fy	227	13	ORF6	ORF6	NNP
cord-312955-gs65c3fy	227	14	,	,	,
cord-312955-gs65c3fy	227	15	ORF8	ORF8	NNP
cord-312955-gs65c3fy	227	16	,	,	,
cord-312955-gs65c3fy	227	17	and	and	CC
cord-312955-gs65c3fy	227	18	nucleocapsid	nucleocapsid	NN
cord-312955-gs65c3fy	227	19	proteins	protein	NNS
cord-312955-gs65c3fy	227	20	were	be	VBD
cord-312955-gs65c3fy	227	21	strong	strong	JJ
cord-312955-gs65c3fy	227	22	inhibitors	inhibitor	NNS
cord-312955-gs65c3fy	227	23	of	of	IN
cord-312955-gs65c3fy	227	24	IFNb	IFNb	NNS
cord-312955-gs65c3fy	227	25	production	production	NN
cord-312955-gs65c3fy	227	26	,	,	,
cord-312955-gs65c3fy	227	27	and	and	CC
cord-312955-gs65c3fy	227	28	through	through	IN
cord-312955-gs65c3fy	227	29	this	this	DT
cord-312955-gs65c3fy	227	30	of	of	IN
cord-312955-gs65c3fy	227	31	the	the	DT
cord-312955-gs65c3fy	227	32	IFN	IFN	NNP
cord-312955-gs65c3fy	227	33	-	-	HYPH
cord-312955-gs65c3fy	227	34	I	-PRON-	PRP
cord-312955-gs65c3fy	227	35	innate	innate	VBP
cord-312955-gs65c3fy	227	36	immune	immune	JJ
cord-312955-gs65c3fy	227	37	response	response	NN
cord-312955-gs65c3fy	227	38	(	(	-LRB-
cord-312955-gs65c3fy	227	39	90	90	CD
cord-312955-gs65c3fy	227	40	)	)	-RRB-
cord-312955-gs65c3fy	227	41	.	.	.
cord-312955-gs65c3fy	228	1	In	in	IN
cord-312955-gs65c3fy	228	2	this	this	DT
cord-312955-gs65c3fy	228	3	study	study	NN
cord-312955-gs65c3fy	228	4	,	,	,
cord-312955-gs65c3fy	228	5	ORF6	ORF6	NNP
cord-312955-gs65c3fy	228	6	and	and	CC
cord-312955-gs65c3fy	228	7	ORF8	ORF8	NNP
cord-312955-gs65c3fy	228	8	also	also	RB
cord-312955-gs65c3fy	228	9	inhibited	inhibit	VBD
cord-312955-gs65c3fy	228	10	induction	induction	NN
cord-312955-gs65c3fy	228	11	of	of	IN
cord-312955-gs65c3fy	228	12	transcription	transcription	NN
cord-312955-gs65c3fy	228	13	an	an	DT
cord-312955-gs65c3fy	228	14	ISRE	ISRE	NNP
cord-312955-gs65c3fy	228	15	promotor	promotor	NN
cord-312955-gs65c3fy	228	16	driving	drive	VBG
cord-312955-gs65c3fy	228	17	a	a	DT
cord-312955-gs65c3fy	228	18	luciferase	luciferase	NN
cord-312955-gs65c3fy	228	19	as	as	IN
cord-312955-gs65c3fy	228	20	reporter	reporter	NN
cord-312955-gs65c3fy	228	21	,	,	,
cord-312955-gs65c3fy	228	22	following	follow	VBG
cord-312955-gs65c3fy	228	23	IFNb	IFNb	NNS
cord-312955-gs65c3fy	228	24	treatment	treatment	NN
cord-312955-gs65c3fy	228	25	.	.	.
cord-312955-gs65c3fy	229	1	In	in	IN
cord-312955-gs65c3fy	229	2	addition	addition	NN
cord-312955-gs65c3fy	229	3	to	to	IN
cord-312955-gs65c3fy	229	4	the	the	DT
cord-312955-gs65c3fy	229	5	above	above	RB
cord-312955-gs65c3fy	229	6	-	-	HYPH
cord-312955-gs65c3fy	229	7	mentioned	mention	VBN
cord-312955-gs65c3fy	229	8	SARS	SARS	NNP
cord-312955-gs65c3fy	229	9	-	-	HYPH
cord-312955-gs65c3fy	229	10	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	229	11	genes	gene	NNS
cord-312955-gs65c3fy	229	12	,	,	,
cord-312955-gs65c3fy	229	13	ORF3b	ORF3b	NNP
cord-312955-gs65c3fy	229	14	was	be	VBD
cord-312955-gs65c3fy	229	15	implicated	implicate	VBN
cord-312955-gs65c3fy	229	16	by	by	IN
cord-312955-gs65c3fy	229	17	Konno	Konno	NNP
cord-312955-gs65c3fy	229	18	et	et	NNP
cord-312955-gs65c3fy	229	19	al	al	NNP
cord-312955-gs65c3fy	229	20	.	.	.
cord-312955-gs65c3fy	230	1	as	as	IN
cord-312955-gs65c3fy	230	2	being	be	VBG
cord-312955-gs65c3fy	230	3	a	a	DT
cord-312955-gs65c3fy	230	4	potent	potent	JJ
cord-312955-gs65c3fy	230	5	antagonist	antagonist	NN
cord-312955-gs65c3fy	230	6	towards	towards	IN
cord-312955-gs65c3fy	230	7	IFN	IFN	NNP
cord-312955-gs65c3fy	230	8	-	-	HYPH
cord-312955-gs65c3fy	230	9	I	-PRON-	PRP
cord-312955-gs65c3fy	230	10	production	production	NN
cord-312955-gs65c3fy	230	11	(	(	-LRB-
cord-312955-gs65c3fy	230	12	91	91	CD
cord-312955-gs65c3fy	230	13	)	)	-RRB-
cord-312955-gs65c3fy	230	14	.	.	.
cord-312955-gs65c3fy	231	1	An	an	DT
cord-312955-gs65c3fy	231	2	interesting	interesting	JJ
cord-312955-gs65c3fy	231	3	civet	civet	NN
cord-312955-gs65c3fy	231	4	in	in	IN
cord-312955-gs65c3fy	231	5	this	this	DT
cord-312955-gs65c3fy	231	6	study	study	NN
cord-312955-gs65c3fy	231	7	is	be	VBZ
cord-312955-gs65c3fy	231	8	the	the	DT
cord-312955-gs65c3fy	231	9	finding	finding	NN
cord-312955-gs65c3fy	231	10	that	that	IN
cord-312955-gs65c3fy	231	11	a	a	DT
cord-312955-gs65c3fy	231	12	natural	natural	JJ
cord-312955-gs65c3fy	231	13	variant	variant	NN
cord-312955-gs65c3fy	231	14	,	,	,
cord-312955-gs65c3fy	231	15	with	with	IN
cord-312955-gs65c3fy	231	16	a	a	DT
cord-312955-gs65c3fy	231	17	longer	long	RBR
cord-312955-gs65c3fy	231	18	ORF3b	ORF3b	NNP
cord-312955-gs65c3fy	231	19	reading	read	VBG
cord-312955-gs65c3fy	231	20	frame	frame	NN
cord-312955-gs65c3fy	231	21	increased	increase	VBN
cord-312955-gs65c3fy	231	22	disease	disease	NN
cord-312955-gs65c3fy	231	23	severity	severity	NN
cord-312955-gs65c3fy	231	24	in	in	IN
cord-312955-gs65c3fy	231	25	two	two	CD
cord-312955-gs65c3fy	231	26	patients	patient	NNS
cord-312955-gs65c3fy	231	27	.	.	.
cord-312955-gs65c3fy	232	1	In	in	IN
cord-312955-gs65c3fy	232	2	light	light	NN
cord-312955-gs65c3fy	232	3	of	of	IN
cord-312955-gs65c3fy	232	4	the	the	DT
cord-312955-gs65c3fy	232	5	much	much	RB
cord-312955-gs65c3fy	232	6	higher	high	JJR
cord-312955-gs65c3fy	232	7	than	than	IN
cord-312955-gs65c3fy	232	8	expected	expect	VBN
cord-312955-gs65c3fy	232	9	coding	coding	NN
cord-312955-gs65c3fy	232	10	capacity	capacity	NN
cord-312955-gs65c3fy	232	11	of	of	IN
cord-312955-gs65c3fy	232	12	the	the	DT
cord-312955-gs65c3fy	232	13	SARS	SARS	NNP
cord-312955-gs65c3fy	232	14	-	-	HYPH
cord-312955-gs65c3fy	232	15	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	232	16	genome	genome	NN
cord-312955-gs65c3fy	232	17	,	,	,
cord-312955-gs65c3fy	232	18	where	where	WRB
cord-312955-gs65c3fy	232	19	many	many	JJ
cord-312955-gs65c3fy	232	20	more	more	JJR
cord-312955-gs65c3fy	232	21	proteins	protein	NNS
cord-312955-gs65c3fy	232	22	than	than	IN
cord-312955-gs65c3fy	232	23	genes	gene	NNS
cord-312955-gs65c3fy	232	24	were	be	VBD
cord-312955-gs65c3fy	232	25	identified	identify	VBN
cord-312955-gs65c3fy	232	26	(	(	-LRB-
cord-312955-gs65c3fy	232	27	92	92	CD
cord-312955-gs65c3fy	232	28	)	)	-RRB-
cord-312955-gs65c3fy	232	29	,	,	,
cord-312955-gs65c3fy	232	30	we	-PRON-	PRP
cord-312955-gs65c3fy	232	31	may	may	MD
cord-312955-gs65c3fy	232	32	find	find	VB
cord-312955-gs65c3fy	232	33	even	even	RB
cord-312955-gs65c3fy	232	34	more	more	JJR
cord-312955-gs65c3fy	232	35	proteins	protein	NNS
cord-312955-gs65c3fy	232	36	and	and	CC
cord-312955-gs65c3fy	232	37	peptides	peptide	NNS
cord-312955-gs65c3fy	232	38	being	be	VBG
cord-312955-gs65c3fy	232	39	involved	involve	VBN
cord-312955-gs65c3fy	232	40	in	in	IN
cord-312955-gs65c3fy	232	41	eliminating	eliminate	VBG
cord-312955-gs65c3fy	232	42	the	the	DT
cord-312955-gs65c3fy	232	43	innate	innate	JJ
cord-312955-gs65c3fy	232	44	immune	immune	JJ
cord-312955-gs65c3fy	232	45	response	response	NN
cord-312955-gs65c3fy	232	46	,	,	,
cord-312955-gs65c3fy	232	47	including	include	VBG
cord-312955-gs65c3fy	232	48	through	through	IN
cord-312955-gs65c3fy	232	49	inhibition	inhibition	NN
cord-312955-gs65c3fy	232	50	of	of	IN
cord-312955-gs65c3fy	232	51	IFN	IFN	NNP
cord-312955-gs65c3fy	232	52	-	-	HYPH
cord-312955-gs65c3fy	232	53	I	I	NNP
cord-312955-gs65c3fy	232	54	activities	activity	NNS
cord-312955-gs65c3fy	232	55	.	.	.
cord-312955-gs65c3fy	233	1	Another	another	DT
cord-312955-gs65c3fy	233	2	mechanism	mechanism	NN
cord-312955-gs65c3fy	233	3	by	by	IN
cord-312955-gs65c3fy	233	4	which	which	WDT
cord-312955-gs65c3fy	233	5	SARS	SARS	NNP
cord-312955-gs65c3fy	233	6	-	-	HYPH
cord-312955-gs65c3fy	233	7	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	233	8	inhibit	inhibit	VB
cord-312955-gs65c3fy	233	9	antiviral	antiviral	JJ
cord-312955-gs65c3fy	233	10	functions	function	NNS
cord-312955-gs65c3fy	233	11	of	of	IN
cord-312955-gs65c3fy	233	12	the	the	DT
cord-312955-gs65c3fy	233	13	cell	cell	NN
cord-312955-gs65c3fy	233	14	is	be	VBZ
cord-312955-gs65c3fy	233	15	thought	think	VBN
cord-312955-gs65c3fy	233	16	the	the	DT
cord-312955-gs65c3fy	233	17	activity	activity	NN
cord-312955-gs65c3fy	233	18	of	of	IN
cord-312955-gs65c3fy	233	19	the	the	DT
cord-312955-gs65c3fy	233	20	papain	papain	NN
cord-312955-gs65c3fy	233	21	-	-	HYPH
cord-312955-gs65c3fy	233	22	like	like	JJ
cord-312955-gs65c3fy	233	23	protease	protease	NN
cord-312955-gs65c3fy	233	24	(	(	-LRB-
cord-312955-gs65c3fy	233	25	PLpro	PLpro	NNP
cord-312955-gs65c3fy	233	26	)	)	-RRB-
cord-312955-gs65c3fy	233	27	,	,	,
cord-312955-gs65c3fy	233	28	which	which	WDT
cord-312955-gs65c3fy	233	29	is	be	VBZ
cord-312955-gs65c3fy	233	30	essential	essential	JJ
cord-312955-gs65c3fy	233	31	for	for	IN
cord-312955-gs65c3fy	233	32	viral	viral	JJ
cord-312955-gs65c3fy	233	33	polyprotein	polyprotein	JJ
cord-312955-gs65c3fy	233	34	processing	processing	NN
cord-312955-gs65c3fy	233	35	.	.	.
cord-312955-gs65c3fy	234	1	This	this	DT
cord-312955-gs65c3fy	234	2	gene	gene	NN
cord-312955-gs65c3fy	234	3	was	be	VBD
cord-312955-gs65c3fy	234	4	found	find	VBN
cord-312955-gs65c3fy	234	5	to	to	TO
cord-312955-gs65c3fy	234	6	preferentially	preferentially	RB
cord-312955-gs65c3fy	234	7	cleave	cleave	VB
cord-312955-gs65c3fy	234	8	the	the	DT
cord-312955-gs65c3fy	234	9	ubiquitin	ubiquitin	NN
cord-312955-gs65c3fy	234	10	-	-	HYPH
cord-312955-gs65c3fy	234	11	like	like	JJ
cord-312955-gs65c3fy	234	12	modifier	modifier	NN
cord-312955-gs65c3fy	234	13	interferon	interferon	NN
cord-312955-gs65c3fy	234	14	-	-	HYPH
cord-312955-gs65c3fy	234	15	stimulated	stimulate	VBN
cord-312955-gs65c3fy	234	16	gene	gene	NN
cord-312955-gs65c3fy	234	17	15	15	CD
cord-312955-gs65c3fy	234	18	(	(	-LRB-
cord-312955-gs65c3fy	234	19	ISG15	ISG15	NNP
cord-312955-gs65c3fy	234	20	)	)	-RRB-
cord-312955-gs65c3fy	234	21	,	,	,
cord-312955-gs65c3fy	234	22	FIGURE	figure	NN
cord-312955-gs65c3fy	234	23	4	4	CD
cord-312955-gs65c3fy	235	1	|	|	NNP
cord-312955-gs65c3fy	235	2	SARS	SARS	NNP
cord-312955-gs65c3fy	235	3	-	-	HYPH
cord-312955-gs65c3fy	235	4	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	235	5	has	have	VBZ
cord-312955-gs65c3fy	235	6	multiple	multiple	JJ
cord-312955-gs65c3fy	235	7	effects	effect	NNS
cord-312955-gs65c3fy	235	8	on	on	IN
cord-312955-gs65c3fy	235	9	the	the	DT
cord-312955-gs65c3fy	235	10	immune	immune	JJ
cord-312955-gs65c3fy	235	11	system	system	NN
cord-312955-gs65c3fy	235	12	,	,	,
cord-312955-gs65c3fy	235	13	including	include	VBG
cord-312955-gs65c3fy	235	14	inhibition	inhibition	NN
cord-312955-gs65c3fy	235	15	of	of	IN
cord-312955-gs65c3fy	235	16	IFNb	ifnb	JJ
cord-312955-gs65c3fy	235	17	production	production	NN
cord-312955-gs65c3fy	235	18	,	,	,
cord-312955-gs65c3fy	235	19	which	which	WDT
cord-312955-gs65c3fy	235	20	results	result	VBZ
cord-312955-gs65c3fy	235	21	in	in	IN
cord-312955-gs65c3fy	235	22	ISGs	isg	NNS
cord-312955-gs65c3fy	235	23	not	not	RB
cord-312955-gs65c3fy	235	24	to	to	TO
cord-312955-gs65c3fy	235	25	be	be	VB
cord-312955-gs65c3fy	235	26	produced	produce	VBN
cord-312955-gs65c3fy	235	27	,	,	,
cord-312955-gs65c3fy	236	1	CD4	CD4	NNP
cord-312955-gs65c3fy	236	2	+	+	CC
cord-312955-gs65c3fy	236	3	and	and	CC
cord-312955-gs65c3fy	236	4	CD8	CD8	NNP
cord-312955-gs65c3fy	236	5	+	+	CC
cord-312955-gs65c3fy	236	6	exhaustion	exhaustion	NN
cord-312955-gs65c3fy	236	7	and	and	CC
cord-312955-gs65c3fy	236	8	increased	increase	VBN
cord-312955-gs65c3fy	236	9	levels	level	NNS
cord-312955-gs65c3fy	236	10	of	of	IN
cord-312955-gs65c3fy	236	11	pro	pro	JJ
cord-312955-gs65c3fy	236	12	-	-	JJ
cord-312955-gs65c3fy	236	13	inflammatory	inflammatory	JJ
cord-312955-gs65c3fy	236	14	proteins	protein	NNS
cord-312955-gs65c3fy	236	15	(	(	-LRB-
cord-312955-gs65c3fy	236	16	TNFa	TNFa	NNP
cord-312955-gs65c3fy	236	17	,	,	,
cord-312955-gs65c3fy	236	18	IL6	il6	NN
cord-312955-gs65c3fy	236	19	,	,	,
cord-312955-gs65c3fy	236	20	NF	NF	NNP
cord-312955-gs65c3fy	236	21	-	-	HYPH
cord-312955-gs65c3fy	236	22	kB	kB	NNP
cord-312955-gs65c3fy	236	23	)	)	-RRB-
cord-312955-gs65c3fy	236	24	.	.	.
cord-312955-gs65c3fy	237	1	Currently	currently	RB
cord-312955-gs65c3fy	237	2	,	,	,
cord-312955-gs65c3fy	237	3	the	the	DT
cord-312955-gs65c3fy	237	4	most	most	RBS
cord-312955-gs65c3fy	237	5	promising	promising	JJ
cord-312955-gs65c3fy	237	6	drugs	drug	NNS
cord-312955-gs65c3fy	237	7	against	against	IN
cord-312955-gs65c3fy	237	8	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	237	9	include	include	VBP
cord-312955-gs65c3fy	237	10	IFN	IFN	NNP
cord-312955-gs65c3fy	237	11	-	-	HYPH
cord-312955-gs65c3fy	237	12	Is	be	VBZ
cord-312955-gs65c3fy	237	13	,	,	,
cord-312955-gs65c3fy	237	14	antiinflammatory	antiinflammatory	JJ
cord-312955-gs65c3fy	237	15	and	and	CC
cord-312955-gs65c3fy	237	16	antiviral	antiviral	JJ
cord-312955-gs65c3fy	237	17	drugs	drug	NNS
cord-312955-gs65c3fy	237	18	,	,	,
cord-312955-gs65c3fy	237	19	protease	protease	NN
cord-312955-gs65c3fy	237	20	inhibitors	inhibitor	NNS
cord-312955-gs65c3fy	237	21	,	,	,
cord-312955-gs65c3fy	237	22	antibodies	antibody	NNS
cord-312955-gs65c3fy	237	23	,	,	,
cord-312955-gs65c3fy	237	24	SARS	SARS	NNP
cord-312955-gs65c3fy	237	25	-	-	HYPH
cord-312955-gs65c3fy	237	26	CoV2	CoV2	NNP
cord-312955-gs65c3fy	237	27	-ACE2	-ACE2	NNP
cord-312955-gs65c3fy	237	28	(	(	-LRB-
cord-312955-gs65c3fy	237	29	receptor	receptor	NN
cord-312955-gs65c3fy	237	30	)	)	-RRB-
cord-312955-gs65c3fy	237	31	binding	bind	VBG
cord-312955-gs65c3fy	237	32	inhibitors	inhibitor	NNS
cord-312955-gs65c3fy	237	33	and	and	CC
cord-312955-gs65c3fy	237	34	more	more	JJR
cord-312955-gs65c3fy	237	35	.	.	.
cord-312955-gs65c3fy	238	1	which	which	WDT
cord-312955-gs65c3fy	238	2	is	be	VBZ
cord-312955-gs65c3fy	238	3	an	an	DT
cord-312955-gs65c3fy	238	4	IFN-	IFN-	NNP
cord-312955-gs65c3fy	239	1	I	-PRON-	PRP
cord-312955-gs65c3fy	239	2	induced	induce	VBD
cord-312955-gs65c3fy	239	3	gene	gene	NN
cord-312955-gs65c3fy	239	4	with	with	IN
cord-312955-gs65c3fy	239	5	strong	strong	JJ
cord-312955-gs65c3fy	239	6	antiviral	antiviral	JJ
cord-312955-gs65c3fy	239	7	activity	activity	NN
cord-312955-gs65c3fy	239	8	(	(	-LRB-
cord-312955-gs65c3fy	239	9	93	93	CD
cord-312955-gs65c3fy	239	10	)	)	-RRB-
cord-312955-gs65c3fy	239	11	.	.	.
cord-312955-gs65c3fy	240	1	This	this	DT
cord-312955-gs65c3fy	240	2	represents	represent	VBZ
cord-312955-gs65c3fy	240	3	another	another	DT
cord-312955-gs65c3fy	240	4	layer	layer	NN
cord-312955-gs65c3fy	240	5	of	of	IN
cord-312955-gs65c3fy	240	6	attenuation	attenuation	NN
cord-312955-gs65c3fy	240	7	of	of	IN
cord-312955-gs65c3fy	240	8	IFN	IFN	NNP
cord-312955-gs65c3fy	240	9	-	-	HYPH
cord-312955-gs65c3fy	240	10	I	-PRON-	PRP
cord-312955-gs65c3fy	240	11	responses	response	NNS
cord-312955-gs65c3fy	240	12	by	by	IN
cord-312955-gs65c3fy	240	13	SARS	SARS	NNP
cord-312955-gs65c3fy	240	14	-	-	HYPH
cord-312955-gs65c3fy	240	15	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	240	16	and	and	CC
cord-312955-gs65c3fy	240	17	is	be	VBZ
cord-312955-gs65c3fy	240	18	similar	similar	JJ
cord-312955-gs65c3fy	240	19	to	to	IN
cord-312955-gs65c3fy	240	20	the	the	DT
cord-312955-gs65c3fy	240	21	mechanism	mechanism	NN
cord-312955-gs65c3fy	240	22	previously	previously	RB
cord-312955-gs65c3fy	240	23	identified	identify	VBN
cord-312955-gs65c3fy	240	24	for	for	IN
cord-312955-gs65c3fy	240	25	SARS	SARS	NNP
cord-312955-gs65c3fy	240	26	-	-	HYPH
cord-312955-gs65c3fy	240	27	CoV	CoV	NNP
cord-312955-gs65c3fy	240	28	(	(	-LRB-
cord-312955-gs65c3fy	240	29	68	68	CD
cord-312955-gs65c3fy	240	30	)	)	-RRB-
cord-312955-gs65c3fy	240	31	.	.	.
cord-312955-gs65c3fy	241	1	Inhibition	inhibition	NN
cord-312955-gs65c3fy	241	2	of	of	IN
cord-312955-gs65c3fy	241	3	IFNb	IFNb	NNS
cord-312955-gs65c3fy	241	4	production	production	NN
cord-312955-gs65c3fy	241	5	by	by	IN
cord-312955-gs65c3fy	241	6	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	241	7	got	get	VBD
cord-312955-gs65c3fy	241	8	further	further	JJ
cord-312955-gs65c3fy	241	9	confirmation	confirmation	NN
cord-312955-gs65c3fy	241	10	from	from	IN
cord-312955-gs65c3fy	241	11	measuring	measure	VBG
cord-312955-gs65c3fy	241	12	the	the	DT
cord-312955-gs65c3fy	241	13	levels	level	NNS
cord-312955-gs65c3fy	241	14	of	of	IN
cord-312955-gs65c3fy	241	15	different	different	JJ
cord-312955-gs65c3fy	241	16	cytokines	cytokine	NNS
cord-312955-gs65c3fy	241	17	in	in	IN
cord-312955-gs65c3fy	241	18	SARS	SARS	NNP
cord-312955-gs65c3fy	241	19	-	-	HYPH
cord-312955-gs65c3fy	241	20	CoV-2-infected	cov-2-infecte	VBN
cord-312955-gs65c3fy	241	21	patients	patient	NNS
cord-312955-gs65c3fy	241	22	.	.	.
cord-312955-gs65c3fy	242	1	An	an	DT
cord-312955-gs65c3fy	242	2	integrated	integrated	JJ
cord-312955-gs65c3fy	242	3	immune	immune	JJ
cord-312955-gs65c3fy	242	4	analysis	analysis	NN
cord-312955-gs65c3fy	242	5	,	,	,
cord-312955-gs65c3fy	242	6	including	include	VBG
cord-312955-gs65c3fy	242	7	immune	immune	JJ
cord-312955-gs65c3fy	242	8	cell	cell	NN
cord-312955-gs65c3fy	242	9	analysis	analysis	NN
cord-312955-gs65c3fy	242	10	,	,	,
cord-312955-gs65c3fy	242	11	whole	whole	JJ
cord-312955-gs65c3fy	242	12	-	-	HYPH
cord-312955-gs65c3fy	242	13	blood	blood	NN
cord-312955-gs65c3fy	242	14	transcriptomics	transcriptomic	NNS
cord-312955-gs65c3fy	242	15	and	and	CC
cord-312955-gs65c3fy	242	16	cytokine	cytokine	NN
cord-312955-gs65c3fy	242	17	quantification	quantification	NN
cord-312955-gs65c3fy	242	18	on	on	IN
cord-312955-gs65c3fy	242	19	COVID-19	covid-19	JJ
cord-312955-gs65c3fy	242	20	patients	patient	NNS
cord-312955-gs65c3fy	242	21	at	at	IN
cord-312955-gs65c3fy	242	22	8	8	CD
cord-312955-gs65c3fy	242	23	to	to	TO
cord-312955-gs65c3fy	242	24	12	12	CD
cord-312955-gs65c3fy	242	25	days	day	NNS
cord-312955-gs65c3fy	242	26	after	after	IN
cord-312955-gs65c3fy	242	27	disease	disease	NN
cord-312955-gs65c3fy	242	28	onset	onset	NN
cord-312955-gs65c3fy	242	29	has	have	VBZ
cord-312955-gs65c3fy	242	30	shown	show	VBN
cord-312955-gs65c3fy	242	31	an	an	DT
cord-312955-gs65c3fy	242	32	impaired	impaired	JJ
cord-312955-gs65c3fy	242	33	IFN	IFN	NNP
cord-312955-gs65c3fy	242	34	-	-	HYPH
cord-312955-gs65c3fy	242	35	I	-PRON-	PRP
cord-312955-gs65c3fy	242	36	response	response	NN
cord-312955-gs65c3fy	242	37	that	that	WDT
cord-312955-gs65c3fy	242	38	is	be	VBZ
cord-312955-gs65c3fy	242	39	a	a	DT
cord-312955-gs65c3fy	242	40	result	result	NN
cord-312955-gs65c3fy	242	41	of	of	IN
cord-312955-gs65c3fy	242	42	low	low	JJ
cord-312955-gs65c3fy	242	43	IFN	IFN	NNP
cord-312955-gs65c3fy	242	44	-	-	HYPH
cord-312955-gs65c3fy	242	45	I	I	NNP
cord-312955-gs65c3fy	242	46	levels	level	NNS
cord-312955-gs65c3fy	242	47	(	(	-LRB-
cord-312955-gs65c3fy	242	48	94	94	CD
cord-312955-gs65c3fy	242	49	)	)	-RRB-
cord-312955-gs65c3fy	242	50	.	.	.
cord-312955-gs65c3fy	243	1	This	this	DT
cord-312955-gs65c3fy	243	2	,	,	,
cord-312955-gs65c3fy	243	3	in	in	IN
cord-312955-gs65c3fy	243	4	turn	turn	NN
cord-312955-gs65c3fy	243	5	results	result	NNS
cord-312955-gs65c3fy	243	6	in	in	IN
cord-312955-gs65c3fy	243	7	the	the	DT
cord-312955-gs65c3fy	243	8	low	low	JJ
cord-312955-gs65c3fy	243	9	production	production	NN
cord-312955-gs65c3fy	243	10	of	of	IN
cord-312955-gs65c3fy	243	11	interferon	interferon	NN
cord-312955-gs65c3fy	243	12	-	-	HYPH
cord-312955-gs65c3fy	243	13	stimulated	stimulate	VBN
cord-312955-gs65c3fy	243	14	genes	gene	NNS
cord-312955-gs65c3fy	243	15	.	.	.
cord-312955-gs65c3fy	244	1	Conversely	conversely	RB
cord-312955-gs65c3fy	244	2	,	,	,
cord-312955-gs65c3fy	244	3	high	high	JJ
cord-312955-gs65c3fy	244	4	levels	level	NNS
cord-312955-gs65c3fy	244	5	of	of	IN
cord-312955-gs65c3fy	244	6	IL6	il6	NN
cord-312955-gs65c3fy	244	7	and	and	CC
cord-312955-gs65c3fy	244	8	TNFa	TNFa	NNP
cord-312955-gs65c3fy	244	9	were	be	VBD
cord-312955-gs65c3fy	244	10	measured	measure	VBN
cord-312955-gs65c3fy	245	1	(	(	-LRB-
cord-312955-gs65c3fy	245	2	Figure	figure	NN
cord-312955-gs65c3fy	245	3	4	4	CD
cord-312955-gs65c3fy	245	4	)	)	-RRB-
cord-312955-gs65c3fy	245	5	(	(	-LRB-
cord-312955-gs65c3fy	245	6	95	95	CD
cord-312955-gs65c3fy	245	7	,	,	,
cord-312955-gs65c3fy	245	8	96	96	CD
cord-312955-gs65c3fy	245	9	)	)	-RRB-
cord-312955-gs65c3fy	245	10	.	.	.
cord-312955-gs65c3fy	246	1	This	this	DT
cord-312955-gs65c3fy	246	2	is	be	VBZ
cord-312955-gs65c3fy	246	3	in	in	IN
cord-312955-gs65c3fy	246	4	contrast	contrast	NN
cord-312955-gs65c3fy	246	5	to	to	IN
cord-312955-gs65c3fy	246	6	what	what	WP
cord-312955-gs65c3fy	246	7	is	be	VBZ
cord-312955-gs65c3fy	246	8	seen	see	VBN
cord-312955-gs65c3fy	246	9	in	in	IN
cord-312955-gs65c3fy	246	10	patients	patient	NNS
cord-312955-gs65c3fy	246	11	infected	infect	VBN
cord-312955-gs65c3fy	246	12	with	with	IN
cord-312955-gs65c3fy	246	13	highly	highly	RB
cord-312955-gs65c3fy	246	14	pathogenic	pathogenic	JJ
cord-312955-gs65c3fy	246	15	influenza	influenza	NN
cord-312955-gs65c3fy	246	16	viruses	virus	NNS
cord-312955-gs65c3fy	246	17	.	.	.
cord-312955-gs65c3fy	247	1	The	the	DT
cord-312955-gs65c3fy	247	2	high	high	JJ
cord-312955-gs65c3fy	247	3	production	production	NN
cord-312955-gs65c3fy	247	4	of	of	IN
cord-312955-gs65c3fy	247	5	pro	pro	JJ
cord-312955-gs65c3fy	247	6	-	-	JJ
cord-312955-gs65c3fy	247	7	inflammatory	inflammatory	JJ
cord-312955-gs65c3fy	247	8	cytokines	cytokine	NNS
cord-312955-gs65c3fy	247	9	and	and	CC
cord-312955-gs65c3fy	247	10	low	low	JJ
cord-312955-gs65c3fy	247	11	production	production	NN
cord-312955-gs65c3fy	247	12	of	of	IN
cord-312955-gs65c3fy	247	13	IFN	IFN	NNP
cord-312955-gs65c3fy	247	14	-	-	,
cord-312955-gs65c3fy	247	15	Is	be	VBZ
cord-312955-gs65c3fy	247	16	during	during	IN
cord-312955-gs65c3fy	248	1	SARS	SARS	NNP
cord-312955-gs65c3fy	248	2	-	-	HYPH
cord-312955-gs65c3fy	248	3	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	248	4	infection	infection	NN
cord-312955-gs65c3fy	248	5	suggests	suggest	VBZ
cord-312955-gs65c3fy	248	6	effective	effective	JJ
cord-312955-gs65c3fy	248	7	activation	activation	NN
cord-312955-gs65c3fy	248	8	of	of	IN
cord-312955-gs65c3fy	248	9	NF	NF	NNP
cord-312955-gs65c3fy	248	10	-	-	HYPH
cord-312955-gs65c3fy	248	11	kB	kB	NNP
cord-312955-gs65c3fy	248	12	but	but	CC
cord-312955-gs65c3fy	248	13	not	not	RB
cord-312955-gs65c3fy	248	14	IRF3	IRF3	NNP
cord-312955-gs65c3fy	248	15	and	and	CC
cord-312955-gs65c3fy	248	16	IRF7	IRF7	NNP
cord-312955-gs65c3fy	248	17	(	(	-LRB-
cord-312955-gs65c3fy	248	18	95	95	CD
cord-312955-gs65c3fy	248	19	)	)	-RRB-
cord-312955-gs65c3fy	248	20	.	.	.
cord-312955-gs65c3fy	249	1	Impaired	impaired	JJ
cord-312955-gs65c3fy	249	2	IFN	IFN	NNP
cord-312955-gs65c3fy	249	3	-	-	HYPH
cord-312955-gs65c3fy	249	4	I	-PRON-	PRP
cord-312955-gs65c3fy	249	5	production	production	NN
cord-312955-gs65c3fy	249	6	during	during	IN
cord-312955-gs65c3fy	249	7	severe	severe	JJ
cord-312955-gs65c3fy	249	8	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	249	9	may	may	MD
cord-312955-gs65c3fy	249	10	also	also	RB
cord-312955-gs65c3fy	249	11	lead	lead	VB
cord-312955-gs65c3fy	249	12	to	to	IN
cord-312955-gs65c3fy	249	13	an	an	DT
cord-312955-gs65c3fy	249	14	imbalance	imbalance	NN
cord-312955-gs65c3fy	249	15	in	in	IN
cord-312955-gs65c3fy	249	16	the	the	DT
cord-312955-gs65c3fy	249	17	pro	pro	JJ
cord-312955-gs65c3fy	249	18	-	-	JJ
cord-312955-gs65c3fy	249	19	inflammatory	inflammatory	JJ
cord-312955-gs65c3fy	249	20	versus	versus	IN
cord-312955-gs65c3fy	249	21	pro	pro	JJ
cord-312955-gs65c3fy	249	22	-	-	JJ
cord-312955-gs65c3fy	249	23	repair	repair	JJ
cord-312955-gs65c3fy	249	24	functions	function	NNS
cord-312955-gs65c3fy	249	25	of	of	IN
cord-312955-gs65c3fy	249	26	airway	airway	NN
cord-312955-gs65c3fy	249	27	macrophages	macrophage	NNS
cord-312955-gs65c3fy	249	28	.	.	.
cord-312955-gs65c3fy	250	1	This	this	DT
cord-312955-gs65c3fy	250	2	was	be	VBD
cord-312955-gs65c3fy	250	3	indeed	indeed	RB
cord-312955-gs65c3fy	250	4	seen	see	VBN
cord-312955-gs65c3fy	250	5	in	in	IN
cord-312955-gs65c3fy	250	6	severely	severely	RB
cord-312955-gs65c3fy	250	7	ill	ill	JJ
cord-312955-gs65c3fy	250	8	patients	patient	NNS
cord-312955-gs65c3fy	250	9	with	with	IN
cord-312955-gs65c3fy	250	10	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	250	11	.	.	.
cord-312955-gs65c3fy	251	1	Other	other	JJ
cord-312955-gs65c3fy	251	2	innate	innate	JJ
cord-312955-gs65c3fy	251	3	immune	immune	JJ
cord-312955-gs65c3fy	251	4	cells	cell	NNS
cord-312955-gs65c3fy	251	5	such	such	JJ
cord-312955-gs65c3fy	251	6	as	as	IN
cord-312955-gs65c3fy	251	7	natural	natural	JJ
cord-312955-gs65c3fy	251	8	killer	killer	NN
cord-312955-gs65c3fy	251	9	(	(	-LRB-
cord-312955-gs65c3fy	251	10	NK	NK	NNP
cord-312955-gs65c3fy	251	11	)	)	-RRB-
cord-312955-gs65c3fy	251	12	cells	cell	NNS
cord-312955-gs65c3fy	251	13	are	be	VBP
cord-312955-gs65c3fy	251	14	also	also	RB
cord-312955-gs65c3fy	251	15	regulated	regulate	VBN
cord-312955-gs65c3fy	251	16	by	by	IN
cord-312955-gs65c3fy	251	17	IFN	IFN	NNP
cord-312955-gs65c3fy	251	18	-	-	,
cord-312955-gs65c3fy	251	19	Is	be	VBZ
cord-312955-gs65c3fy	251	20	during	during	IN
cord-312955-gs65c3fy	251	21	coronavirus	coronavirus	NN
cord-312955-gs65c3fy	251	22	infection	infection	NN
cord-312955-gs65c3fy	251	23	.	.	.
cord-312955-gs65c3fy	252	1	Severe	severe	JJ
cord-312955-gs65c3fy	252	2	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	252	3	is	be	VBZ
cord-312955-gs65c3fy	252	4	associated	associate	VBN
cord-312955-gs65c3fy	252	5	with	with	IN
cord-312955-gs65c3fy	252	6	exhaustion	exhaustion	NN
cord-312955-gs65c3fy	252	7	of	of	IN
cord-312955-gs65c3fy	252	8	CD4	CD4	NNP
cord-312955-gs65c3fy	252	9	+	+	CC
cord-312955-gs65c3fy	252	10	and	and	CC
cord-312955-gs65c3fy	252	11	CD8	CD8	NNP
cord-312955-gs65c3fy	252	12	+	+	CC
cord-312955-gs65c3fy	252	13	T	T	NNP
cord-312955-gs65c3fy	252	14	cells	cell	NNS
cord-312955-gs65c3fy	252	15	(	(	-LRB-
cord-312955-gs65c3fy	252	16	97	97	CD
cord-312955-gs65c3fy	252	17	)	)	-RRB-
cord-312955-gs65c3fy	252	18	,	,	,
cord-312955-gs65c3fy	252	19	which	which	WDT
cord-312955-gs65c3fy	252	20	may	may	MD
cord-312955-gs65c3fy	252	21	be	be	VB
cord-312955-gs65c3fy	252	22	a	a	DT
cord-312955-gs65c3fy	252	23	result	result	NN
cord-312955-gs65c3fy	252	24	of	of	IN
cord-312955-gs65c3fy	252	25	deficient	deficient	JJ
cord-312955-gs65c3fy	252	26	IFN	IFN	NNP
cord-312955-gs65c3fy	252	27	-	-	HYPH
cord-312955-gs65c3fy	252	28	I	i	NN
cord-312955-gs65c3fy	252	29	production	production	NN
cord-312955-gs65c3fy	252	30	,	,	,
cord-312955-gs65c3fy	252	31	as	as	IN
cord-312955-gs65c3fy	252	32	IFN	IFN	NNP
cord-312955-gs65c3fy	252	33	-	-	:
cord-312955-gs65c3fy	252	34	Is	be	VBZ
cord-312955-gs65c3fy	252	35	promote	promote	VB
cord-312955-gs65c3fy	252	36	survival	survival	NN
cord-312955-gs65c3fy	252	37	of	of	IN
cord-312955-gs65c3fy	252	38	T	t	NN
cord-312955-gs65c3fy	252	39	cells	cell	NNS
cord-312955-gs65c3fy	252	40	.	.	.
cord-312955-gs65c3fy	253	1	An	an	DT
cord-312955-gs65c3fy	253	2	important	important	JJ
cord-312955-gs65c3fy	253	3	issue	issue	NN
cord-312955-gs65c3fy	253	4	to	to	TO
cord-312955-gs65c3fy	253	5	consider	consider	VB
cord-312955-gs65c3fy	253	6	is	be	VBZ
cord-312955-gs65c3fy	253	7	that	that	IN
cord-312955-gs65c3fy	253	8	early	early	JJ
cord-312955-gs65c3fy	253	9	production	production	NN
cord-312955-gs65c3fy	253	10	of	of	IN
cord-312955-gs65c3fy	253	11	IFN	IFN	NNP
cord-312955-gs65c3fy	253	12	-	-	:
cord-312955-gs65c3fy	253	13	Is	be	VBZ
cord-312955-gs65c3fy	253	14	promote	promote	VB
cord-312955-gs65c3fy	253	15	efficient	efficient	JJ
cord-312955-gs65c3fy	253	16	T	t	NN
cord-312955-gs65c3fy	253	17	cell	cell	NN
cord-312955-gs65c3fy	253	18	responses	response	NNS
cord-312955-gs65c3fy	253	19	,	,	,
cord-312955-gs65c3fy	253	20	while	while	IN
cord-312955-gs65c3fy	253	21	a	a	DT
cord-312955-gs65c3fy	253	22	delayed	delay	VBN
cord-312955-gs65c3fy	253	23	response	response	NN
cord-312955-gs65c3fy	253	24	may	may	MD
cord-312955-gs65c3fy	253	25	inhibit	inhibit	VB
cord-312955-gs65c3fy	253	26	T	t	NN
cord-312955-gs65c3fy	253	27	cell	cell	NN
cord-312955-gs65c3fy	253	28	proliferation	proliferation	NN
cord-312955-gs65c3fy	253	29	or	or	CC
cord-312955-gs65c3fy	253	30	their	-PRON-	PRP$
cord-312955-gs65c3fy	253	31	exit	exit	NN
cord-312955-gs65c3fy	253	32	from	from	IN
cord-312955-gs65c3fy	253	33	lymphoid	lymphoid	JJ
cord-312955-gs65c3fy	253	34	organs	organ	NNS
cord-312955-gs65c3fy	253	35	and	and	CC
cord-312955-gs65c3fy	253	36	thus	thus	RB
cord-312955-gs65c3fy	253	37	cause	cause	VB
cord-312955-gs65c3fy	253	38	their	-PRON-	PRP$
cord-312955-gs65c3fy	253	39	functional	functional	JJ
cord-312955-gs65c3fy	253	40	exhaustion	exhaustion	NN
cord-312955-gs65c3fy	253	41	.	.	.
cord-312955-gs65c3fy	254	1	Indeed	indeed	RB
cord-312955-gs65c3fy	254	2	,	,	,
cord-312955-gs65c3fy	254	3	T	T	NNP
cord-312955-gs65c3fy	254	4	reg	reg	NN
cord-312955-gs65c3fy	254	5	cell	cell	NN
cord-312955-gs65c3fy	254	6	counts	count	VBZ
cord-312955-gs65c3fy	254	7	in	in	IN
cord-312955-gs65c3fy	255	1	COVID-19	covid-19	JJ
cord-312955-gs65c3fy	255	2	patients	patient	NNS
cord-312955-gs65c3fy	255	3	inversely	inversely	RB
cord-312955-gs65c3fy	255	4	correlate	correlate	VBP
cord-312955-gs65c3fy	255	5	with	with	IN
cord-312955-gs65c3fy	255	6	disease	disease	NN
cord-312955-gs65c3fy	255	7	severity	severity	NN
cord-312955-gs65c3fy	255	8	(	(	-LRB-
cord-312955-gs65c3fy	255	9	98	98	CD
cord-312955-gs65c3fy	255	10	,	,	,
cord-312955-gs65c3fy	255	11	99	99	CD
cord-312955-gs65c3fy	255	12	)	)	-RRB-
cord-312955-gs65c3fy	255	13	.	.	.
cord-312955-gs65c3fy	256	1	Interestingly	interestingly	RB
cord-312955-gs65c3fy	256	2	,	,	,
cord-312955-gs65c3fy	256	3	transcriptomic	transcriptomic	JJ
cord-312955-gs65c3fy	256	4	analysis	analysis	NN
cord-312955-gs65c3fy	256	5	of	of	IN
cord-312955-gs65c3fy	256	6	blood	blood	NN
cord-312955-gs65c3fy	256	7	,	,	,
cord-312955-gs65c3fy	256	8	lung	lung	NN
cord-312955-gs65c3fy	256	9	,	,	,
cord-312955-gs65c3fy	256	10	and	and	CC
cord-312955-gs65c3fy	256	11	airways	airway	NNS
cord-312955-gs65c3fy	256	12	of	of	IN
cord-312955-gs65c3fy	256	13	CoV-2-infected	cov-2-infected	JJ
cord-312955-gs65c3fy	256	14	patients	patient	NNS
cord-312955-gs65c3fy	256	15	showed	show	VBD
cord-312955-gs65c3fy	256	16	that	that	IN
cord-312955-gs65c3fy	256	17	while	while	IN
cord-312955-gs65c3fy	256	18	IFNb	IFNb	NNS
cord-312955-gs65c3fy	256	19	was	be	VBD
cord-312955-gs65c3fy	256	20	indeed	indeed	RB
cord-312955-gs65c3fy	256	21	not	not	RB
cord-312955-gs65c3fy	256	22	highly	highly	RB
cord-312955-gs65c3fy	256	23	expressed	express	VBN
cord-312955-gs65c3fy	256	24	in	in	IN
cord-312955-gs65c3fy	256	25	either	either	DT
cord-312955-gs65c3fy	256	26	,	,	,
cord-312955-gs65c3fy	256	27	a	a	DT
cord-312955-gs65c3fy	256	28	number	number	NN
cord-312955-gs65c3fy	256	29	of	of	IN
cord-312955-gs65c3fy	256	30	IFNas	IFNas	NNP
cord-312955-gs65c3fy	256	31	were	be	VBD
cord-312955-gs65c3fy	256	32	highly	highly	RB
cord-312955-gs65c3fy	256	33	upregulated	upregulate	VBN
cord-312955-gs65c3fy	256	34	in	in	IN
cord-312955-gs65c3fy	256	35	the	the	DT
cord-312955-gs65c3fy	256	36	lung	lung	NN
cord-312955-gs65c3fy	256	37	and	and	CC
cord-312955-gs65c3fy	256	38	airways	airway	NNS
cord-312955-gs65c3fy	256	39	but	but	CC
cord-312955-gs65c3fy	256	40	not	not	RB
cord-312955-gs65c3fy	256	41	in	in	IN
cord-312955-gs65c3fy	256	42	blood	blood	NN
cord-312955-gs65c3fy	256	43	(	(	-LRB-
cord-312955-gs65c3fy	256	44	100	100	CD
cord-312955-gs65c3fy	256	45	)	)	-RRB-
cord-312955-gs65c3fy	256	46	.	.	.
cord-312955-gs65c3fy	257	1	Moreover	moreover	RB
cord-312955-gs65c3fy	257	2	,	,	,
cord-312955-gs65c3fy	257	3	a	a	DT
cord-312955-gs65c3fy	257	4	clear	clear	JJ
cord-312955-gs65c3fy	257	5	IFN	IFN	NNP
cord-312955-gs65c3fy	257	6	-	-	HYPH
cord-312955-gs65c3fy	257	7	I	I	NNP
cord-312955-gs65c3fy	257	8	-	-	HYPH
cord-312955-gs65c3fy	257	9	induced	induce	VBN
cord-312955-gs65c3fy	257	10	gene	gene	NN
cord-312955-gs65c3fy	257	11	expression	expression	NN
cord-312955-gs65c3fy	257	12	profile	profile	NN
cord-312955-gs65c3fy	257	13	was	be	VBD
cord-312955-gs65c3fy	257	14	also	also	RB
cord-312955-gs65c3fy	257	15	detected	detect	VBN
cord-312955-gs65c3fy	257	16	for	for	IN
cord-312955-gs65c3fy	257	17	lung	lung	NN
cord-312955-gs65c3fy	257	18	and	and	CC
cord-312955-gs65c3fy	257	19	airways	airway	NNS
cord-312955-gs65c3fy	257	20	,	,	,
cord-312955-gs65c3fy	257	21	but	but	CC
cord-312955-gs65c3fy	257	22	not	not	RB
cord-312955-gs65c3fy	257	23	for	for	IN
cord-312955-gs65c3fy	257	24	blood	blood	NN
cord-312955-gs65c3fy	257	25	(	(	-LRB-
cord-312955-gs65c3fy	257	26	PBMCs	pbmc	NNS
cord-312955-gs65c3fy	257	27	)	)	-RRB-
cord-312955-gs65c3fy	257	28	.	.	.
cord-312955-gs65c3fy	258	1	A	a	DT
cord-312955-gs65c3fy	258	2	similar	similar	JJ
cord-312955-gs65c3fy	258	3	finding	finding	NN
cord-312955-gs65c3fy	258	4	of	of	IN
cord-312955-gs65c3fy	258	5	elevated	elevated	JJ
cord-312955-gs65c3fy	258	6	IFNa	IFNa	NNS
cord-312955-gs65c3fy	258	7	but	but	CC
cord-312955-gs65c3fy	258	8	not	not	RB
cord-312955-gs65c3fy	258	9	IFNb	IFNb	NNS
cord-312955-gs65c3fy	258	10	,	,	,
cord-312955-gs65c3fy	258	11	during	during	IN
cord-312955-gs65c3fy	258	12	COVID-19	covid-19	JJ
cord-312955-gs65c3fy	258	13	infection	infection	NN
cord-312955-gs65c3fy	258	14	was	be	VBD
cord-312955-gs65c3fy	258	15	also	also	RB
cord-312955-gs65c3fy	258	16	found	find	VBN
cord-312955-gs65c3fy	258	17	by	by	IN
cord-312955-gs65c3fy	258	18	Wei	Wei	NNP
cord-312955-gs65c3fy	258	19	et	et	NNP
cord-312955-gs65c3fy	258	20	al	al	NNP
cord-312955-gs65c3fy	258	21	.	.	.
cord-312955-gs65c3fy	259	1	(	(	-LRB-
cord-312955-gs65c3fy	259	2	101	101	CD
cord-312955-gs65c3fy	259	3	)	)	-RRB-
cord-312955-gs65c3fy	259	4	.	.	.
cord-312955-gs65c3fy	260	1	In	in	IN
cord-312955-gs65c3fy	260	2	this	this	DT
cord-312955-gs65c3fy	260	3	study	study	NN
cord-312955-gs65c3fy	260	4	,	,	,
cord-312955-gs65c3fy	260	5	the	the	DT
cord-312955-gs65c3fy	260	6	elevated	elevated	JJ
cord-312955-gs65c3fy	260	7	IFN	IFN	NNP
cord-312955-gs65c3fy	260	8	-	-	HYPH
cord-312955-gs65c3fy	260	9	I	I	NNP
cord-312955-gs65c3fy	260	10	response	response	NN
cord-312955-gs65c3fy	260	11	was	be	VBD
cord-312955-gs65c3fy	260	12	restricted	restrict	VBN
cord-312955-gs65c3fy	260	13	to	to	IN
cord-312955-gs65c3fy	260	14	the	the	DT
cord-312955-gs65c3fy	260	15	stage	stage	NN
cord-312955-gs65c3fy	260	16	in	in	IN
cord-312955-gs65c3fy	260	17	the	the	DT
cord-312955-gs65c3fy	260	18	disease	disease	NN
cord-312955-gs65c3fy	260	19	were	be	VBD
cord-312955-gs65c3fy	260	20	patients	patient	NNS
cord-312955-gs65c3fy	260	21	were	be	VBD
cord-312955-gs65c3fy	260	22	in	in	IN
cord-312955-gs65c3fy	260	23	intensive	intensive	JJ
cord-312955-gs65c3fy	260	24	care	care	NN
cord-312955-gs65c3fy	260	25	.	.	.
cord-312955-gs65c3fy	261	1	In	in	IN
cord-312955-gs65c3fy	261	2	another	another	DT
cord-312955-gs65c3fy	261	3	study	study	NN
cord-312955-gs65c3fy	261	4	of	of	IN
cord-312955-gs65c3fy	261	5	26	26	CD
cord-312955-gs65c3fy	261	6	patients	patient	NNS
cord-312955-gs65c3fy	261	7	,	,	,
cord-312955-gs65c3fy	261	8	of	of	IN
cord-312955-gs65c3fy	261	9	whom	whom	WP
cord-312955-gs65c3fy	261	10	5	5	CD
cord-312955-gs65c3fy	261	11	did	do	VBD
cord-312955-gs65c3fy	261	12	not	not	RB
cord-312955-gs65c3fy	261	13	produce	produce	VB
cord-312955-gs65c3fy	261	14	IFN	IFN	NNP
cord-312955-gs65c3fy	261	15	-	-	HYPH
cord-312955-gs65c3fy	261	16	I	I	NNP
cord-312955-gs65c3fy	261	17	,	,	,
cord-312955-gs65c3fy	261	18	those	those	DT
cord-312955-gs65c3fy	261	19	patients	patient	NNS
cord-312955-gs65c3fy	261	20	had	have	VBD
cord-312955-gs65c3fy	261	21	higher	high	JJR
cord-312955-gs65c3fy	261	22	viral	viral	JJ
cord-312955-gs65c3fy	261	23	load	load	NN
cord-312955-gs65c3fy	261	24	,	,	,
cord-312955-gs65c3fy	261	25	required	require	VBD
cord-312955-gs65c3fy	261	26	more	more	RBR
cord-312955-gs65c3fy	261	27	aggressive	aggressive	JJ
cord-312955-gs65c3fy	261	28	medical	medical	JJ
cord-312955-gs65c3fy	261	29	intervention	intervention	NN
cord-312955-gs65c3fy	261	30	and	and	CC
cord-312955-gs65c3fy	261	31	their	-PRON-	PRP$
cord-312955-gs65c3fy	261	32	time	time	NN
cord-312955-gs65c3fy	261	33	of	of	IN
cord-312955-gs65c3fy	261	34	stay	stay	NN
cord-312955-gs65c3fy	261	35	in	in	IN
cord-312955-gs65c3fy	261	36	the	the	DT
cord-312955-gs65c3fy	261	37	intensive	intensive	JJ
cord-312955-gs65c3fy	261	38	care	care	NN
cord-312955-gs65c3fy	261	39	unit	unit	NN
cord-312955-gs65c3fy	261	40	was	be	VBD
cord-312955-gs65c3fy	261	41	longer	long	JJR
cord-312955-gs65c3fy	261	42	that	that	IN
cord-312955-gs65c3fy	261	43	IFN	IFN	NNP
cord-312955-gs65c3fy	261	44	-	-	HYPH
cord-312955-gs65c3fy	261	45	I	I	NNP
cord-312955-gs65c3fy	261	46	producing	produce	VBG
cord-312955-gs65c3fy	261	47	patients	patient	NNS
cord-312955-gs65c3fy	261	48	(	(	-LRB-
cord-312955-gs65c3fy	261	49	102	102	CD
cord-312955-gs65c3fy	261	50	)	)	-RRB-
cord-312955-gs65c3fy	261	51	.	.	.
cord-312955-gs65c3fy	262	1	PDCs	pdc	NNS
cord-312955-gs65c3fy	262	2	are	be	VBP
cord-312955-gs65c3fy	262	3	the	the	DT
cord-312955-gs65c3fy	262	4	most	most	RBS
cord-312955-gs65c3fy	262	5	rapid	rapid	JJ
cord-312955-gs65c3fy	262	6	and	and	CC
cord-312955-gs65c3fy	262	7	abundant	abundant	JJ
cord-312955-gs65c3fy	262	8	IFN	IFN	NNP
cord-312955-gs65c3fy	262	9	-	-	HYPH
cord-312955-gs65c3fy	262	10	I	-PRON-	PRP
cord-312955-gs65c3fy	262	11	producers	producer	NNS
cord-312955-gs65c3fy	262	12	.	.	.
cord-312955-gs65c3fy	263	1	PDCs	pdc	NNS
cord-312955-gs65c3fy	263	2	express	express	VBP
cord-312955-gs65c3fy	263	3	TLR7	TLR7	NNP
cord-312955-gs65c3fy	263	4	and	and	CC
cord-312955-gs65c3fy	263	5	TLR9	TLR9	NNP
cord-312955-gs65c3fy	263	6	which	which	WDT
cord-312955-gs65c3fy	263	7	are	be	VBP
cord-312955-gs65c3fy	263	8	important	important	JJ
cord-312955-gs65c3fy	263	9	in	in	IN
cord-312955-gs65c3fy	263	10	sensing	sense	VBG
cord-312955-gs65c3fy	263	11	viruses	virus	NNS
cord-312955-gs65c3fy	263	12	.	.	.
cord-312955-gs65c3fy	264	1	The	the	DT
cord-312955-gs65c3fy	264	2	response	response	NN
cord-312955-gs65c3fy	264	3	of	of	IN
cord-312955-gs65c3fy	264	4	PDCs	pdc	NNS
cord-312955-gs65c3fy	264	5	to	to	IN
cord-312955-gs65c3fy	264	6	viruses	virus	NNS
cord-312955-gs65c3fy	264	7	,	,	,
cord-312955-gs65c3fy	264	8	particularly	particularly	RB
cord-312955-gs65c3fy	264	9	IFN	IFN	NNP
cord-312955-gs65c3fy	264	10	-	-	HYPH
cord-312955-gs65c3fy	264	11	I	-PRON-	PRP
cord-312955-gs65c3fy	264	12	production	production	NN
cord-312955-gs65c3fy	264	13	,	,	,
cord-312955-gs65c3fy	264	14	is	be	VBZ
cord-312955-gs65c3fy	264	15	significantly	significantly	RB
cord-312955-gs65c3fy	264	16	impaired	impair	VBN
cord-312955-gs65c3fy	264	17	with	with	IN
cord-312955-gs65c3fy	264	18	ageing	age	VBG
cord-312955-gs65c3fy	264	19	while	while	IN
cord-312955-gs65c3fy	264	20	secretion	secretion	NN
cord-312955-gs65c3fy	264	21	of	of	IN
cord-312955-gs65c3fy	264	22	all	all	DT
cord-312955-gs65c3fy	264	23	other	other	JJ
cord-312955-gs65c3fy	264	24	pro	pro	JJ
cord-312955-gs65c3fy	264	25	-	-	JJ
cord-312955-gs65c3fy	264	26	inflammatory	inflammatory	JJ
cord-312955-gs65c3fy	264	27	cytokines	cytokine	NNS
cord-312955-gs65c3fy	264	28	was	be	VBD
cord-312955-gs65c3fy	264	29	comparable	comparable	JJ
cord-312955-gs65c3fy	264	30	to	to	IN
cord-312955-gs65c3fy	264	31	that	that	DT
cord-312955-gs65c3fy	264	32	of	of	IN
cord-312955-gs65c3fy	264	33	younger	young	JJR
cord-312955-gs65c3fy	264	34	individuals	individual	NNS
cord-312955-gs65c3fy	264	35	(	(	-LRB-
cord-312955-gs65c3fy	264	36	103	103	CD
cord-312955-gs65c3fy	264	37	)	)	-RRB-
cord-312955-gs65c3fy	264	38	.	.	.
cord-312955-gs65c3fy	265	1	This	this	DT
cord-312955-gs65c3fy	265	2	may	may	MD
cord-312955-gs65c3fy	265	3	relate	relate	VB
cord-312955-gs65c3fy	265	4	to	to	IN
cord-312955-gs65c3fy	265	5	the	the	DT
cord-312955-gs65c3fy	265	6	master	master	NN
cord-312955-gs65c3fy	265	7	regulator	regulator	NN
cord-312955-gs65c3fy	265	8	for	for	IN
cord-312955-gs65c3fy	265	9	IFN	IFN	NNP
cord-312955-gs65c3fy	265	10	-	-	HYPH
cord-312955-gs65c3fy	265	11	I	-PRON-	PRP
cord-312955-gs65c3fy	265	12	production	production	NN
cord-312955-gs65c3fy	265	13	,	,	,
cord-312955-gs65c3fy	265	14	IRF7	IRF7	NNP
cord-312955-gs65c3fy	265	15	,	,	,
cord-312955-gs65c3fy	265	16	which	which	WDT
cord-312955-gs65c3fy	265	17	expression	expression	NN
cord-312955-gs65c3fy	265	18	,	,	,
cord-312955-gs65c3fy	265	19	phosphorylation	phosphorylation	NN
cord-312955-gs65c3fy	265	20	and	and	CC
cord-312955-gs65c3fy	265	21	nuclear	nuclear	JJ
cord-312955-gs65c3fy	265	22	translocation	translocation	NN
cord-312955-gs65c3fy	265	23	decreases	decrease	VBZ
cord-312955-gs65c3fy	265	24	with	with	IN
cord-312955-gs65c3fy	265	25	age	age	NN
cord-312955-gs65c3fy	265	26	.	.	.
cord-312955-gs65c3fy	266	1	In	in	IN
cord-312955-gs65c3fy	266	2	addition	addition	NN
cord-312955-gs65c3fy	266	3	,	,	,
cord-312955-gs65c3fy	266	4	local	local	JJ
cord-312955-gs65c3fy	266	5	neutrophil	neutrophil	NN
cord-312955-gs65c3fy	266	6	-	-	HYPH
cord-312955-gs65c3fy	266	7	mediated	mediate	VBN
cord-312955-gs65c3fy	266	8	inflammation	inflammation	NN
cord-312955-gs65c3fy	266	9	is	be	VBZ
cord-312955-gs65c3fy	266	10	increased	increase	VBN
cord-312955-gs65c3fy	266	11	with	with	IN
cord-312955-gs65c3fy	266	12	age	age	NN
cord-312955-gs65c3fy	266	13	,	,	,
cord-312955-gs65c3fy	266	14	while	while	IN
cord-312955-gs65c3fy	266	15	cytotoxicity	cytotoxicity	NN
cord-312955-gs65c3fy	266	16	of	of	IN
cord-312955-gs65c3fy	266	17	NK	NK	NNP
cord-312955-gs65c3fy	266	18	cells	cell	NNS
cord-312955-gs65c3fy	266	19	induced	induce	VBN
cord-312955-gs65c3fy	266	20	by	by	IN
cord-312955-gs65c3fy	266	21	type	type	NN
cord-312955-gs65c3fy	267	1	I	-PRON-	PRP
cord-312955-gs65c3fy	267	2	IFN	IFN	NNP
cord-312955-gs65c3fy	267	3	-	-	HYPH
cord-312955-gs65c3fy	267	4	Is	be	VBZ
cord-312955-gs65c3fy	267	5	decreases	decrease	NNS
cord-312955-gs65c3fy	267	6	in	in	IN
cord-312955-gs65c3fy	267	7	aged	aged	JJ
cord-312955-gs65c3fy	267	8	mice	mouse	NNS
cord-312955-gs65c3fy	267	9	(	(	-LRB-
cord-312955-gs65c3fy	267	10	104	104	CD
cord-312955-gs65c3fy	267	11	)	)	-RRB-
cord-312955-gs65c3fy	267	12	.	.	.
cord-312955-gs65c3fy	268	1	In	in	IN
cord-312955-gs65c3fy	268	2	addition	addition	NN
cord-312955-gs65c3fy	268	3	to	to	IN
cord-312955-gs65c3fy	268	4	age	age	NN
cord-312955-gs65c3fy	268	5	,	,	,
cord-312955-gs65c3fy	268	6	other	other	JJ
cord-312955-gs65c3fy	268	7	factors	factor	NNS
cord-312955-gs65c3fy	268	8	were	be	VBD
cord-312955-gs65c3fy	268	9	also	also	RB
cord-312955-gs65c3fy	268	10	associated	associate	VBN
cord-312955-gs65c3fy	268	11	with	with	IN
cord-312955-gs65c3fy	268	12	reduced	reduce	VBN
cord-312955-gs65c3fy	268	13	interferon	interferon	NN
cord-312955-gs65c3fy	268	14	responses	response	NNS
cord-312955-gs65c3fy	268	15	.	.	.
cord-312955-gs65c3fy	269	1	One	one	CD
cord-312955-gs65c3fy	269	2	of	of	IN
cord-312955-gs65c3fy	269	3	them	-PRON-	PRP
cord-312955-gs65c3fy	269	4	is	be	VBZ
cord-312955-gs65c3fy	269	5	obesity	obesity	NN
cord-312955-gs65c3fy	269	6	,	,	,
cord-312955-gs65c3fy	269	7	which	which	WDT
cord-312955-gs65c3fy	269	8	is	be	VBZ
cord-312955-gs65c3fy	269	9	related	relate	VBN
cord-312955-gs65c3fy	269	10	to	to	IN
cord-312955-gs65c3fy	269	11	impaired	impaired	JJ
cord-312955-gs65c3fy	269	12	IFNa	IFNa	NNS
cord-312955-gs65c3fy	269	13	and	and	CC
cord-312955-gs65c3fy	269	14	IFNb	ifnb	JJ
cord-312955-gs65c3fy	269	15	responses	response	NNS
cord-312955-gs65c3fy	269	16	,	,	,
cord-312955-gs65c3fy	269	17	which	which	WDT
cord-312955-gs65c3fy	269	18	may	may	MD
cord-312955-gs65c3fy	269	19	relate	relate	VB
cord-312955-gs65c3fy	269	20	to	to	IN
cord-312955-gs65c3fy	269	21	inadequate	inadequate	JJ
cord-312955-gs65c3fy	269	22	response	response	NN
cord-312955-gs65c3fy	269	23	of	of	IN
cord-312955-gs65c3fy	269	24	obese	obese	JJ
cord-312955-gs65c3fy	269	25	people	people	NNS
cord-312955-gs65c3fy	269	26	against	against	IN
cord-312955-gs65c3fy	269	27	viral	viral	JJ
cord-312955-gs65c3fy	269	28	infections	infection	NNS
cord-312955-gs65c3fy	269	29	(	(	-LRB-
cord-312955-gs65c3fy	269	30	105	105	CD
cord-312955-gs65c3fy	269	31	)	)	-RRB-
cord-312955-gs65c3fy	269	32	.	.	.
cord-312955-gs65c3fy	270	1	Clinical	clinical	JJ
cord-312955-gs65c3fy	270	2	trials	trial	NNS
cord-312955-gs65c3fy	270	3	of	of	IN
cord-312955-gs65c3fy	270	4	using	use	VBG
cord-312955-gs65c3fy	270	5	IFN	IFN	NNP
cord-312955-gs65c3fy	270	6	-	-	HYPH
cord-312955-gs65c3fy	270	7	I	I	NNP
cord-312955-gs65c3fy	270	8	for	for	IN
cord-312955-gs65c3fy	270	9	treating	treat	VBG
cord-312955-gs65c3fy	270	10	corona	corona	NN
cord-312955-gs65c3fy	270	11	viruses	virus	NNS
cord-312955-gs65c3fy	270	12	has	have	VBZ
cord-312955-gs65c3fy	270	13	a	a	DT
cord-312955-gs65c3fy	270	14	long	long	JJ
cord-312955-gs65c3fy	270	15	history	history	NN
cord-312955-gs65c3fy	270	16	.	.	.
cord-312955-gs65c3fy	271	1	Already	already	RB
cord-312955-gs65c3fy	271	2	in	in	IN
cord-312955-gs65c3fy	271	3	1983	1983	CD
cord-312955-gs65c3fy	271	4	,	,	,
cord-312955-gs65c3fy	271	5	intranasal	intranasal	NNP
cord-312955-gs65c3fy	271	6	human	human	NNP
cord-312955-gs65c3fy	271	7	IFNa2	IFNa2	NNP
cord-312955-gs65c3fy	271	8	was	be	VBD
cord-312955-gs65c3fy	271	9	given	give	VBN
cord-312955-gs65c3fy	271	10	both	both	CC
cord-312955-gs65c3fy	271	11	before	before	IN
cord-312955-gs65c3fy	271	12	and	and	CC
cord-312955-gs65c3fy	271	13	after	after	IN
cord-312955-gs65c3fy	271	14	corona	corona	NNP
cord-312955-gs65c3fy	271	15	virus	virus	NN
cord-312955-gs65c3fy	271	16	challenge	challenge	NN
cord-312955-gs65c3fy	271	17	,	,	,
cord-312955-gs65c3fy	271	18	a	a	DT
cord-312955-gs65c3fy	271	19	strain	strain	NN
cord-312955-gs65c3fy	271	20	that	that	WDT
cord-312955-gs65c3fy	271	21	is	be	VBZ
cord-312955-gs65c3fy	271	22	causing	cause	VBG
cord-312955-gs65c3fy	271	23	common	common	JJ
cord-312955-gs65c3fy	271	24	cold	cold	NN
cord-312955-gs65c3fy	271	25	.	.	.
cord-312955-gs65c3fy	272	1	The	the	DT
cord-312955-gs65c3fy	272	2	incidence	incidence	NN
cord-312955-gs65c3fy	272	3	of	of	IN
cord-312955-gs65c3fy	272	4	colds	cold	NNS
cord-312955-gs65c3fy	272	5	,	,	,
cord-312955-gs65c3fy	272	6	the	the	DT
cord-312955-gs65c3fy	272	7	severity	severity	NN
cord-312955-gs65c3fy	272	8	of	of	IN
cord-312955-gs65c3fy	272	9	symptoms	symptom	NNS
cord-312955-gs65c3fy	272	10	and	and	CC
cord-312955-gs65c3fy	272	11	signs	sign	NNS
cord-312955-gs65c3fy	272	12	,	,	,
cord-312955-gs65c3fy	272	13	and	and	CC
cord-312955-gs65c3fy	272	14	virus	virus	NN
cord-312955-gs65c3fy	272	15	replication	replication	NN
cord-312955-gs65c3fy	272	16	were	be	VBD
cord-312955-gs65c3fy	272	17	all	all	DT
cord-312955-gs65c3fy	272	18	reduced	reduce	VBN
cord-312955-gs65c3fy	272	19	in	in	IN
cord-312955-gs65c3fy	272	20	subjects	subject	NNS
cord-312955-gs65c3fy	272	21	receiving	receive	VBG
cord-312955-gs65c3fy	272	22	interferon	interferon	NN
cord-312955-gs65c3fy	272	23	as	as	IN
cord-312955-gs65c3fy	272	24	compared	compare	VBN
cord-312955-gs65c3fy	272	25	with	with	IN
cord-312955-gs65c3fy	272	26	those	those	DT
cord-312955-gs65c3fy	272	27	given	give	VBN
cord-312955-gs65c3fy	272	28	placebo	placebo	NN
cord-312955-gs65c3fy	272	29	(	(	-LRB-
cord-312955-gs65c3fy	272	30	106	106	CD
cord-312955-gs65c3fy	272	31	)	)	-RRB-
cord-312955-gs65c3fy	272	32	.	.	.
cord-312955-gs65c3fy	273	1	For	for	IN
cord-312955-gs65c3fy	273	2	SARS	SARS	NNP
cord-312955-gs65c3fy	273	3	-	-	HYPH
cord-312955-gs65c3fy	273	4	CoV	CoV	NNP
cord-312955-gs65c3fy	273	5	,	,	,
cord-312955-gs65c3fy	273	6	no	no	DT
cord-312955-gs65c3fy	273	7	randomized	randomized	JJ
cord-312955-gs65c3fy	273	8	placebo	placebo	NN
cord-312955-gs65c3fy	273	9	-	-	HYPH
cord-312955-gs65c3fy	273	10	controlled	control	VBN
cord-312955-gs65c3fy	273	11	trials	trial	NNS
cord-312955-gs65c3fy	273	12	have	have	VBP
cord-312955-gs65c3fy	273	13	been	be	VBN
cord-312955-gs65c3fy	273	14	performed	perform	VBN
cord-312955-gs65c3fy	273	15	to	to	TO
cord-312955-gs65c3fy	273	16	test	test	VB
cord-312955-gs65c3fy	273	17	the	the	DT
cord-312955-gs65c3fy	273	18	efficacy	efficacy	NN
cord-312955-gs65c3fy	273	19	of	of	IN
cord-312955-gs65c3fy	273	20	IFN	IFN	NNP
cord-312955-gs65c3fy	273	21	-	-	HYPH
cord-312955-gs65c3fy	273	22	Is	be	VBZ
cord-312955-gs65c3fy	273	23	,	,	,
cord-312955-gs65c3fy	273	24	however	however	RB
cord-312955-gs65c3fy	273	25	,	,	,
cord-312955-gs65c3fy	273	26	comparing	compare	VBG
cord-312955-gs65c3fy	273	27	the	the	DT
cord-312955-gs65c3fy	273	28	clinical	clinical	JJ
cord-312955-gs65c3fy	273	29	outcome	outcome	NN
cord-312955-gs65c3fy	273	30	of	of	IN
cord-312955-gs65c3fy	273	31	patients	patient	NNS
cord-312955-gs65c3fy	273	32	treated	treat	VBN
cord-312955-gs65c3fy	273	33	with	with	IN
cord-312955-gs65c3fy	273	34	IFN	IFN	NNP
cord-312955-gs65c3fy	273	35	-	-	:
cord-312955-gs65c3fy	273	36	a	a	NNP
cord-312955-gs65c3fy	273	37	(	(	-LRB-
cord-312955-gs65c3fy	273	38	infacon-1	infacon-1	NNP
cord-312955-gs65c3fy	273	39	)	)	-RRB-
cord-312955-gs65c3fy	273	40	with	with	IN
cord-312955-gs65c3fy	273	41	patients	patient	NNS
cord-312955-gs65c3fy	273	42	at	at	IN
cord-312955-gs65c3fy	273	43	different	different	JJ
cord-312955-gs65c3fy	273	44	locations	location	NNS
cord-312955-gs65c3fy	273	45	(	(	-LRB-
cord-312955-gs65c3fy	273	46	not	not	RB
cord-312955-gs65c3fy	273	47	a	a	DT
cord-312955-gs65c3fy	273	48	control	control	NN
cord-312955-gs65c3fy	273	49	group	group	NN
cord-312955-gs65c3fy	273	50	)	)	-RRB-
cord-312955-gs65c3fy	273	51	that	that	WDT
cord-312955-gs65c3fy	273	52	were	be	VBD
cord-312955-gs65c3fy	273	53	not	not	RB
cord-312955-gs65c3fy	273	54	treated	treat	VBN
cord-312955-gs65c3fy	273	55	,	,	,
cord-312955-gs65c3fy	273	56	has	have	VBZ
cord-312955-gs65c3fy	273	57	suggested	suggest	VBN
cord-312955-gs65c3fy	273	58	clinical	clinical	JJ
cord-312955-gs65c3fy	273	59	benefits	benefit	NNS
cord-312955-gs65c3fy	273	60	(	(	-LRB-
cord-312955-gs65c3fy	273	61	107	107	CD
cord-312955-gs65c3fy	273	62	)	)	-RRB-
cord-312955-gs65c3fy	273	63	.	.	.
cord-312955-gs65c3fy	274	1	These	these	DT
cord-312955-gs65c3fy	274	2	studies	study	NNS
cord-312955-gs65c3fy	274	3	have	have	VBP
cord-312955-gs65c3fy	274	4	raised	raise	VBN
cord-312955-gs65c3fy	274	5	the	the	DT
cord-312955-gs65c3fy	274	6	hope	hope	NN
cord-312955-gs65c3fy	274	7	that	that	IN
cord-312955-gs65c3fy	274	8	IFN	IFN	NNP
cord-312955-gs65c3fy	274	9	-	-	HYPH
cord-312955-gs65c3fy	274	10	I	-PRON-	PRP
cord-312955-gs65c3fy	274	11	may	may	MD
cord-312955-gs65c3fy	274	12	be	be	VB
cord-312955-gs65c3fy	274	13	a	a	DT
cord-312955-gs65c3fy	274	14	potent	potent	JJ
cord-312955-gs65c3fy	274	15	drug	drug	NN
cord-312955-gs65c3fy	274	16	also	also	RB
cord-312955-gs65c3fy	274	17	against	against	IN
cord-312955-gs65c3fy	274	18	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	274	19	.	.	.
cord-312955-gs65c3fy	275	1	This	this	DT
cord-312955-gs65c3fy	275	2	hope	hope	NN
cord-312955-gs65c3fy	275	3	was	be	VBD
cord-312955-gs65c3fy	275	4	further	further	RB
cord-312955-gs65c3fy	275	5	exuberated	exuberate	VBN
cord-312955-gs65c3fy	275	6	by	by	IN
cord-312955-gs65c3fy	275	7	the	the	DT
cord-312955-gs65c3fy	275	8	observation	observation	NN
cord-312955-gs65c3fy	275	9	that	that	WDT
cord-312955-gs65c3fy	275	10	externally	externally	RB
cord-312955-gs65c3fy	275	11	administrated	administrate	VBD
cord-312955-gs65c3fy	275	12	IFN	IFN	NNP
cord-312955-gs65c3fy	275	13	-	-	HYPH
cord-312955-gs65c3fy	275	14	I	-PRON-	PRP
cord-312955-gs65c3fy	275	15	induced	induce	VBD
cord-312955-gs65c3fy	275	16	a	a	DT
cord-312955-gs65c3fy	275	17	strong	strong	JJ
cord-312955-gs65c3fy	275	18	antiviral	antiviral	JJ
cord-312955-gs65c3fy	275	19	response	response	NN
cord-312955-gs65c3fy	275	20	,	,	,
cord-312955-gs65c3fy	275	21	much	much	RB
cord-312955-gs65c3fy	275	22	more	more	JJR
cord-312955-gs65c3fy	275	23	than	than	IN
cord-312955-gs65c3fy	275	24	that	that	DT
cord-312955-gs65c3fy	275	25	observed	observe	VBD
cord-312955-gs65c3fy	275	26	for	for	IN
cord-312955-gs65c3fy	275	27	SARS	SARS	NNP
cord-312955-gs65c3fy	275	28	-	-	HYPH
cord-312955-gs65c3fy	275	29	CoV	CoV	NNP
cord-312955-gs65c3fy	275	30	(	(	-LRB-
cord-312955-gs65c3fy	275	31	86	86	CD
cord-312955-gs65c3fy	275	32	)	)	-RRB-
cord-312955-gs65c3fy	275	33	.	.	.
cord-312955-gs65c3fy	276	1	While	while	IN
cord-312955-gs65c3fy	276	2	some	some	DT
cord-312955-gs65c3fy	276	3	of	of	IN
cord-312955-gs65c3fy	276	4	the	the	DT
cord-312955-gs65c3fy	276	5	SARS	SARS	NNP
cord-312955-gs65c3fy	276	6	-	-	HYPH
cord-312955-gs65c3fy	276	7	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	276	8	proteins	protein	NNS
cord-312955-gs65c3fy	276	9	may	may	MD
cord-312955-gs65c3fy	276	10	affect	affect	VB
cord-312955-gs65c3fy	276	11	ISG	ISG	NNP
cord-312955-gs65c3fy	276	12	production	production	NN
cord-312955-gs65c3fy	276	13	(	(	-LRB-
cord-312955-gs65c3fy	276	14	most	most	RBS
cord-312955-gs65c3fy	276	15	notably	notably	RB
cord-312955-gs65c3fy	276	16	,	,	,
cord-312955-gs65c3fy	276	17	ORF6	ORF6	NNP
cord-312955-gs65c3fy	276	18	and	and	CC
cord-312955-gs65c3fy	276	19	8	8	CD
cord-312955-gs65c3fy	276	20	,	,	,
cord-312955-gs65c3fy	276	21	see	see	VBP
cord-312955-gs65c3fy	276	22	above	above	RB
cord-312955-gs65c3fy	276	23	)	)	-RRB-
cord-312955-gs65c3fy	276	24	,	,	,
cord-312955-gs65c3fy	276	25	the	the	DT
cord-312955-gs65c3fy	276	26	main	main	JJ
cord-312955-gs65c3fy	276	27	defense	defense	NN
cord-312955-gs65c3fy	276	28	of	of	IN
cord-312955-gs65c3fy	276	29	SARS	SARS	NNP
cord-312955-gs65c3fy	276	30	-	-	HYPH
cord-312955-gs65c3fy	276	31	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	276	32	against	against	IN
cord-312955-gs65c3fy	276	33	IFN	IFN	NNP
cord-312955-gs65c3fy	276	34	-	-	HYPH
cord-312955-gs65c3fy	276	35	I	-PRON-	PRP
cord-312955-gs65c3fy	276	36	innate	innate	VBP
cord-312955-gs65c3fy	276	37	immunity	immunity	NN
cord-312955-gs65c3fy	276	38	seems	seem	VBZ
cord-312955-gs65c3fy	276	39	to	to	TO
cord-312955-gs65c3fy	276	40	be	be	VB
cord-312955-gs65c3fy	276	41	the	the	DT
cord-312955-gs65c3fy	276	42	prevention	prevention	NN
cord-312955-gs65c3fy	276	43	of	of	IN
cord-312955-gs65c3fy	276	44	IFNb	IFNb	NNS
cord-312955-gs65c3fy	276	45	production	production	NN
cord-312955-gs65c3fy	276	46	,	,	,
cord-312955-gs65c3fy	276	47	which	which	WDT
cord-312955-gs65c3fy	276	48	can	can	MD
cord-312955-gs65c3fy	276	49	be	be	VB
cord-312955-gs65c3fy	276	50	substituted	substitute	VBN
cord-312955-gs65c3fy	276	51	by	by	IN
cord-312955-gs65c3fy	276	52	external	external	JJ
cord-312955-gs65c3fy	276	53	administration	administration	NN
cord-312955-gs65c3fy	276	54	.	.	.
cord-312955-gs65c3fy	277	1	A	a	DT
cord-312955-gs65c3fy	277	2	major	major	JJ
cord-312955-gs65c3fy	277	3	problem	problem	NN
cord-312955-gs65c3fy	277	4	in	in	IN
cord-312955-gs65c3fy	277	5	assessing	assess	VBG
cord-312955-gs65c3fy	277	6	the	the	DT
cord-312955-gs65c3fy	277	7	efficiency	efficiency	NN
cord-312955-gs65c3fy	277	8	of	of	IN
cord-312955-gs65c3fy	277	9	IFN	IFN	NNP
cord-312955-gs65c3fy	277	10	-	-	HYPH
cord-312955-gs65c3fy	277	11	I	I	NNP
cord-312955-gs65c3fy	277	12	against	against	IN
cord-312955-gs65c3fy	277	13	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	277	14	is	be	VBZ
cord-312955-gs65c3fy	277	15	the	the	DT
cord-312955-gs65c3fy	277	16	lack	lack	NN
cord-312955-gs65c3fy	277	17	of	of	IN
cord-312955-gs65c3fy	277	18	a	a	DT
cord-312955-gs65c3fy	277	19	good	good	JJ
cord-312955-gs65c3fy	277	20	small	small	JJ
cord-312955-gs65c3fy	277	21	animal	animal	NN
cord-312955-gs65c3fy	277	22	model	model	NN
cord-312955-gs65c3fy	277	23	.	.	.
cord-312955-gs65c3fy	278	1	While	while	IN
cord-312955-gs65c3fy	278	2	such	such	JJ
cord-312955-gs65c3fy	278	3	models	model	NNS
cord-312955-gs65c3fy	278	4	are	be	VBP
cord-312955-gs65c3fy	278	5	now	now	RB
cord-312955-gs65c3fy	278	6	under	under	IN
cord-312955-gs65c3fy	278	7	development	development	NN
cord-312955-gs65c3fy	278	8	,	,	,
cord-312955-gs65c3fy	278	9	they	-PRON-	PRP
cord-312955-gs65c3fy	278	10	are	be	VBP
cord-312955-gs65c3fy	278	11	still	still	RB
cord-312955-gs65c3fy	278	12	not	not	RB
cord-312955-gs65c3fy	278	13	perfect	perfect	JJ
cord-312955-gs65c3fy	278	14	.	.	.
cord-312955-gs65c3fy	279	1	In	in	IN
cord-312955-gs65c3fy	279	2	a	a	DT
cord-312955-gs65c3fy	279	3	recent	recent	JJ
cord-312955-gs65c3fy	279	4	study	study	NN
cord-312955-gs65c3fy	279	5	,	,	,
cord-312955-gs65c3fy	279	6	mice	mouse	NNS
cord-312955-gs65c3fy	279	7	were	be	VBD
cord-312955-gs65c3fy	279	8	infected	infect	VBN
cord-312955-gs65c3fy	279	9	with	with	IN
cord-312955-gs65c3fy	279	10	a	a	DT
cord-312955-gs65c3fy	279	11	replication	replication	NN
cord-312955-gs65c3fy	279	12	-	-	HYPH
cord-312955-gs65c3fy	279	13	deficient	deficient	JJ
cord-312955-gs65c3fy	279	14	adenovirus	adenovirus	NN
cord-312955-gs65c3fy	279	15	containing	contain	VBG
cord-312955-gs65c3fy	279	16	human	human	JJ
cord-312955-gs65c3fy	279	17	ACE2	ACE2	NNP
cord-312955-gs65c3fy	279	18	,	,	,
cord-312955-gs65c3fy	279	19	and	and	CC
cord-312955-gs65c3fy	279	20	then	then	RB
cord-312955-gs65c3fy	279	21	infected	infect	VBN
cord-312955-gs65c3fy	279	22	with	with	IN
cord-312955-gs65c3fy	279	23	SARS	SARS	NNP
cord-312955-gs65c3fy	279	24	-	-	HYPH
cord-312955-gs65c3fy	279	25	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	279	26	.	.	.
cord-312955-gs65c3fy	280	1	These	these	DT
cord-312955-gs65c3fy	280	2	mice	mouse	NNS
cord-312955-gs65c3fy	280	3	developed	develop	VBD
cord-312955-gs65c3fy	280	4	pneumonia	pneumonia	NN
cord-312955-gs65c3fy	280	5	,	,	,
cord-312955-gs65c3fy	280	6	severe	severe	JJ
cord-312955-gs65c3fy	280	7	pulmonary	pulmonary	JJ
cord-312955-gs65c3fy	280	8	pathology	pathology	NN
cord-312955-gs65c3fy	280	9	,	,	,
cord-312955-gs65c3fy	280	10	and	and	CC
cord-312955-gs65c3fy	280	11	high	high	JJ
cord-312955-gs65c3fy	280	12	-	-	HYPH
cord-312955-gs65c3fy	280	13	titer	titer	NN
cord-312955-gs65c3fy	280	14	virus	virus	NN
cord-312955-gs65c3fy	280	15	replication	replication	NN
cord-312955-gs65c3fy	280	16	in	in	IN
cord-312955-gs65c3fy	280	17	lungs	lung	NNS
cord-312955-gs65c3fy	280	18	.	.	.
cord-312955-gs65c3fy	281	1	To	to	TO
cord-312955-gs65c3fy	281	2	test	test	VB
cord-312955-gs65c3fy	281	3	the	the	DT
cord-312955-gs65c3fy	281	4	role	role	NN
cord-312955-gs65c3fy	281	5	of	of	IN
cord-312955-gs65c3fy	281	6	IFN	IFN	NNP
cord-312955-gs65c3fy	281	7	-	-	HYPH
cord-312955-gs65c3fy	281	8	I	I	NNP
cord-312955-gs65c3fy	281	9	in	in	IN
cord-312955-gs65c3fy	281	10	disease	disease	NN
cord-312955-gs65c3fy	281	11	development	development	NN
cord-312955-gs65c3fy	281	12	,	,	,
cord-312955-gs65c3fy	281	13	IFNAR1	IFNAR1	''
cord-312955-gs65c3fy	281	14	KO	KO	NNP
cord-312955-gs65c3fy	281	15	mice	mouse	NNS
cord-312955-gs65c3fy	281	16	were	be	VBD
cord-312955-gs65c3fy	281	17	infected	infect	VBN
cord-312955-gs65c3fy	281	18	with	with	IN
cord-312955-gs65c3fy	281	19	SARS	SARS	NNP
cord-312955-gs65c3fy	281	20	-	-	HYPH
cord-312955-gs65c3fy	281	21	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	281	22	,	,	,
cord-312955-gs65c3fy	281	23	showing	show	VBG
cord-312955-gs65c3fy	281	24	higher	high	JJR
cord-312955-gs65c3fy	281	25	viral	viral	JJ
cord-312955-gs65c3fy	281	26	titer	titer	NN
cord-312955-gs65c3fy	281	27	over	over	IN
cord-312955-gs65c3fy	281	28	time	time	NN
cord-312955-gs65c3fy	281	29	.	.	.
cord-312955-gs65c3fy	282	1	Next	next	RB
cord-312955-gs65c3fy	282	2	,	,	,
cord-312955-gs65c3fy	282	3	the	the	DT
cord-312955-gs65c3fy	282	4	mice	mouse	NNS
cord-312955-gs65c3fy	282	5	were	be	VBD
cord-312955-gs65c3fy	282	6	treated	treat	VBN
cord-312955-gs65c3fy	282	7	prior	prior	RB
cord-312955-gs65c3fy	282	8	to	to	IN
cord-312955-gs65c3fy	282	9	infection	infection	NN
cord-312955-gs65c3fy	282	10	with	with	IN
cord-312955-gs65c3fy	282	11	Poly	Poly	NNP
cord-312955-gs65c3fy	282	12	I	I	NNP
cord-312955-gs65c3fy	283	1	:	:	:
cord-312955-gs65c3fy	283	2	C	C	NNP
cord-312955-gs65c3fy	283	3	,	,	,
cord-312955-gs65c3fy	283	4	a	a	DT
cord-312955-gs65c3fy	283	5	strong	strong	JJ
cord-312955-gs65c3fy	283	6	inducer	inducer	NN
cord-312955-gs65c3fy	283	7	of	of	IN
cord-312955-gs65c3fy	283	8	IFN	IFN	NNP
cord-312955-gs65c3fy	283	9	-	-	HYPH
cord-312955-gs65c3fy	283	10	I.	I.	NNP
cord-312955-gs65c3fy	283	11	This	This	NNP
cord-312955-gs65c3fy	283	12	resulted	result	VBD
cord-312955-gs65c3fy	283	13	in	in	IN
cord-312955-gs65c3fy	283	14	significantly	significantly	RB
cord-312955-gs65c3fy	283	15	diminished	diminish	VBN
cord-312955-gs65c3fy	283	16	clinical	clinical	JJ
cord-312955-gs65c3fy	283	17	disease	disease	NN
cord-312955-gs65c3fy	283	18	and	and	CC
cord-312955-gs65c3fy	283	19	induced	induce	VBN
cord-312955-gs65c3fy	283	20	more	more	RBR
cord-312955-gs65c3fy	283	21	rapid	rapid	JJ
cord-312955-gs65c3fy	283	22	virus	virus	NN
cord-312955-gs65c3fy	283	23	clearance	clearance	NN
cord-312955-gs65c3fy	283	24	(	(	-LRB-
cord-312955-gs65c3fy	283	25	108	108	CD
cord-312955-gs65c3fy	283	26	)	)	-RRB-
cord-312955-gs65c3fy	283	27	.	.	.
cord-312955-gs65c3fy	284	1	These	these	DT
cord-312955-gs65c3fy	284	2	results	result	NNS
cord-312955-gs65c3fy	284	3	suggest	suggest	VBP
cord-312955-gs65c3fy	284	4	that	that	IN
cord-312955-gs65c3fy	284	5	at	at	IN
cord-312955-gs65c3fy	284	6	least	least	JJS
cord-312955-gs65c3fy	284	7	in	in	IN
cord-312955-gs65c3fy	284	8	a	a	DT
cord-312955-gs65c3fy	284	9	mice	mice	NN
cord-312955-gs65c3fy	284	10	model	model	NN
cord-312955-gs65c3fy	284	11	,	,	,
cord-312955-gs65c3fy	284	12	IFN	IFN	NNP
cord-312955-gs65c3fy	284	13	-	-	HYPH
cord-312955-gs65c3fy	284	14	I	-PRON-	PRP
cord-312955-gs65c3fy	284	15	may	may	MD
cord-312955-gs65c3fy	284	16	benefit	benefit	VB
cord-312955-gs65c3fy	284	17	disease	disease	NN
cord-312955-gs65c3fy	284	18	recovery	recovery	NN
cord-312955-gs65c3fy	284	19	.	.	.
cord-312955-gs65c3fy	285	1	Due	due	IN
cord-312955-gs65c3fy	285	2	to	to	IN
cord-312955-gs65c3fy	285	3	the	the	DT
cord-312955-gs65c3fy	285	4	lack	lack	NN
cord-312955-gs65c3fy	285	5	of	of	IN
cord-312955-gs65c3fy	285	6	a	a	DT
cord-312955-gs65c3fy	285	7	good	good	JJ
cord-312955-gs65c3fy	285	8	animal	animal	NN
cord-312955-gs65c3fy	285	9	model	model	NN
cord-312955-gs65c3fy	285	10	,	,	,
cord-312955-gs65c3fy	285	11	and	and	CC
cord-312955-gs65c3fy	285	12	the	the	DT
cord-312955-gs65c3fy	285	13	availability	availability	NN
cord-312955-gs65c3fy	285	14	of	of	IN
cord-312955-gs65c3fy	285	15	clinically	clinically	RB
cord-312955-gs65c3fy	285	16	approved	approve	VBN
cord-312955-gs65c3fy	285	17	IFN	IFN	NNP
cord-312955-gs65c3fy	285	18	-	-	HYPH
cord-312955-gs65c3fy	285	19	I	-PRON-	PRP
cord-312955-gs65c3fy	285	20	therapies	therapy	NNS
cord-312955-gs65c3fy	285	21	,	,	,
cord-312955-gs65c3fy	285	22	multiple	multiple	JJ
cord-312955-gs65c3fy	285	23	clinical	clinical	JJ
cord-312955-gs65c3fy	285	24	studies	study	NNS
cord-312955-gs65c3fy	285	25	have	have	VBP
cord-312955-gs65c3fy	285	26	been	be	VBN
cord-312955-gs65c3fy	285	27	conducted	conduct	VBN
cord-312955-gs65c3fy	285	28	administrating	administrate	VBG
cord-312955-gs65c3fy	285	29	different	different	JJ
cord-312955-gs65c3fy	285	30	subtypes	subtype	NNS
cord-312955-gs65c3fy	285	31	of	of	IN
cord-312955-gs65c3fy	285	32	IFN	IFN	NNP
cord-312955-gs65c3fy	285	33	-	-	:
cord-312955-gs65c3fy	285	34	Is	be	VBZ
cord-312955-gs65c3fy	285	35	using	use	VBG
cord-312955-gs65c3fy	285	36	different	different	JJ
cord-312955-gs65c3fy	285	37	routes	route	NNS
cord-312955-gs65c3fy	285	38	of	of	IN
cord-312955-gs65c3fy	285	39	administration	administration	NN
cord-312955-gs65c3fy	285	40	(	(	-LRB-
cord-312955-gs65c3fy	285	41	for	for	IN
cord-312955-gs65c3fy	285	42	summary	summary	NN
cord-312955-gs65c3fy	285	43	see	see	VB
cord-312955-gs65c3fy	285	44	Table	Table	NNP
cord-312955-gs65c3fy	285	45	1	1	CD
cord-312955-gs65c3fy	285	46	)	)	-RRB-
cord-312955-gs65c3fy	285	47	.	.	.
cord-312955-gs65c3fy	286	1	In	in	IN
cord-312955-gs65c3fy	286	2	a	a	DT
cord-312955-gs65c3fy	286	3	preventive	preventive	JJ
cord-312955-gs65c3fy	286	4	study	study	NN
cord-312955-gs65c3fy	286	5	,	,	,
cord-312955-gs65c3fy	286	6	nasal	nasal	NN
cord-312955-gs65c3fy	286	7	drops	drop	NNS
cord-312955-gs65c3fy	286	8	of	of	IN
cord-312955-gs65c3fy	286	9	IFNa1	IFNa1	NNP
cord-312955-gs65c3fy	286	10	were	be	VBD
cord-312955-gs65c3fy	286	11	given	give	VBN
cord-312955-gs65c3fy	286	12	to	to	IN
cord-312955-gs65c3fy	286	13	2,944	2,944	CD
cord-312955-gs65c3fy	286	14	healthy	healthy	JJ
cord-312955-gs65c3fy	286	15	medical	medical	JJ
cord-312955-gs65c3fy	286	16	staff	staff	NN
cord-312955-gs65c3fy	286	17	in	in	IN
cord-312955-gs65c3fy	286	18	Shiyan	Shiyan	NNP
cord-312955-gs65c3fy	286	19	City	City	NNP
cord-312955-gs65c3fy	286	20	hospital	hospital	NN
cord-312955-gs65c3fy	286	21	,	,	,
cord-312955-gs65c3fy	286	22	Hubei	Hubei	NNP
cord-312955-gs65c3fy	286	23	Province	Province	NNP
cord-312955-gs65c3fy	286	24	for	for	IN
cord-312955-gs65c3fy	286	25	28	28	CD
cord-312955-gs65c3fy	286	26	days	day	NNS
cord-312955-gs65c3fy	286	27	to	to	TO
cord-312955-gs65c3fy	286	28	prevent	prevent	VB
cord-312955-gs65c3fy	286	29	SARS	SARS	NNP
cord-312955-gs65c3fy	286	30	-	-	HYPH
cord-312955-gs65c3fy	286	31	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	286	32	infections	infection	NNS
cord-312955-gs65c3fy	286	33	.	.	.
cord-312955-gs65c3fy	287	1	None	none	NN
cord-312955-gs65c3fy	287	2	of	of	IN
cord-312955-gs65c3fy	287	3	them	-PRON-	PRP
cord-312955-gs65c3fy	287	4	developed	develop	VBD
cord-312955-gs65c3fy	287	5	serious	serious	JJ
cord-312955-gs65c3fy	287	6	side	side	NN
cord-312955-gs65c3fy	287	7	effects	effect	NNS
cord-312955-gs65c3fy	287	8	or	or	CC
cord-312955-gs65c3fy	287	9	was	be	VBD
cord-312955-gs65c3fy	287	10	infected	infect	VBN
cord-312955-gs65c3fy	287	11	with	with	IN
cord-312955-gs65c3fy	287	12	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	287	13	.	.	.
cord-312955-gs65c3fy	288	1	While	while	IN
cord-312955-gs65c3fy	288	2	the	the	DT
cord-312955-gs65c3fy	288	3	study	study	NN
cord-312955-gs65c3fy	288	4	lacked	lack	VBD
cord-312955-gs65c3fy	288	5	a	a	DT
cord-312955-gs65c3fy	288	6	control	control	NN
cord-312955-gs65c3fy	288	7	group	group	NN
cord-312955-gs65c3fy	288	8	from	from	IN
cord-312955-gs65c3fy	288	9	the	the	DT
cord-312955-gs65c3fy	288	10	same	same	JJ
cord-312955-gs65c3fy	288	11	city	city	NN
cord-312955-gs65c3fy	288	12	,	,	,
cord-312955-gs65c3fy	288	13	overall	overall	RB
cord-312955-gs65c3fy	288	14	in	in	IN
cord-312955-gs65c3fy	288	15	Hubei	Hubei	NNP
cord-312955-gs65c3fy	288	16	province	province	NN
cord-312955-gs65c3fy	288	17	3,387	3,387	CD
cord-312955-gs65c3fy	288	18	medical	medical	JJ
cord-312955-gs65c3fy	288	19	staff	staff	NN
cord-312955-gs65c3fy	288	20	were	be	VBD
cord-312955-gs65c3fy	288	21	diagnosed	diagnose	VBN
cord-312955-gs65c3fy	288	22	with	with	IN
cord-312955-gs65c3fy	288	23	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	288	24	(	(	-LRB-
cord-312955-gs65c3fy	288	25	109	109	CD
cord-312955-gs65c3fy	288	26	)	)	-RRB-
cord-312955-gs65c3fy	288	27	.	.	.
cord-312955-gs65c3fy	289	1	The	the	DT
cord-312955-gs65c3fy	289	2	study	study	NN
cord-312955-gs65c3fy	289	3	thus	thus	RB
cord-312955-gs65c3fy	289	4	gives	give	VBZ
cord-312955-gs65c3fy	289	5	an	an	DT
cord-312955-gs65c3fy	289	6	indication	indication	NN
cord-312955-gs65c3fy	289	7	that	that	IN
cord-312955-gs65c3fy	289	8	IFN	IFN	NNP
cord-312955-gs65c3fy	289	9	-	-	HYPH
cord-312955-gs65c3fy	289	10	I	-PRON-	PRP
cord-312955-gs65c3fy	289	11	may	may	MD
cord-312955-gs65c3fy	289	12	help	help	VB
cord-312955-gs65c3fy	289	13	in	in	IN
cord-312955-gs65c3fy	289	14	preventing	prevent	VBG
cord-312955-gs65c3fy	289	15	infection	infection	NN
cord-312955-gs65c3fy	289	16	for	for	IN
cord-312955-gs65c3fy	289	17	high	high	JJ
cord-312955-gs65c3fy	289	18	risk	risk	NN
cord-312955-gs65c3fy	289	19	medical	medical	JJ
cord-312955-gs65c3fy	289	20	personal	personal	NN
cord-312955-gs65c3fy	289	21	.	.	.
cord-312955-gs65c3fy	290	1	To	to	TO
cord-312955-gs65c3fy	290	2	test	test	VB
cord-312955-gs65c3fy	290	3	the	the	DT
cord-312955-gs65c3fy	290	4	benefit	benefit	NN
cord-312955-gs65c3fy	290	5	of	of	IN
cord-312955-gs65c3fy	290	6	subcutaneous	subcutaneous	JJ
cord-312955-gs65c3fy	290	7	injection	injection	NN
cord-312955-gs65c3fy	290	8	of	of	IN
cord-312955-gs65c3fy	290	9	IFNb	IFNb	NNS
cord-312955-gs65c3fy	290	10	on	on	IN
cord-312955-gs65c3fy	290	11	early	early	JJ
cord-312955-gs65c3fy	290	12	stage	stage	NN
cord-312955-gs65c3fy	290	13	patients	patient	NNS
cord-312955-gs65c3fy	290	14	,	,	,
cord-312955-gs65c3fy	290	15	an	an	DT
cord-312955-gs65c3fy	290	16	open	open	JJ
cord-312955-gs65c3fy	290	17	clinical	clinical	JJ
cord-312955-gs65c3fy	290	18	trial	trial	NN
cord-312955-gs65c3fy	290	19	was	be	VBD
cord-312955-gs65c3fy	290	20	conducted	conduct	VBN
cord-312955-gs65c3fy	290	21	with	with	IN
cord-312955-gs65c3fy	290	22	127	127	CD
cord-312955-gs65c3fy	290	23	patients	patient	NNS
cord-312955-gs65c3fy	290	24	,	,	,
cord-312955-gs65c3fy	290	25	86	86	CD
cord-312955-gs65c3fy	290	26	were	be	VBD
cord-312955-gs65c3fy	290	27	assigned	assign	VBN
cord-312955-gs65c3fy	290	28	to	to	IN
cord-312955-gs65c3fy	290	29	the	the	DT
cord-312955-gs65c3fy	290	30	combination	combination	NN
cord-312955-gs65c3fy	290	31	of	of	IN
cord-312955-gs65c3fy	290	32	lopinavir	lopinavir	NNS
cord-312955-gs65c3fy	290	33	,	,	,
cord-312955-gs65c3fy	290	34	ritonavir	ritonavir	NNP
cord-312955-gs65c3fy	290	35	,	,	,
cord-312955-gs65c3fy	290	36	ribavirin	ribavirin	NN
cord-312955-gs65c3fy	290	37	,	,	,
cord-312955-gs65c3fy	290	38	and	and	CC
cord-312955-gs65c3fy	290	39	three	three	CD
cord-312955-gs65c3fy	290	40	doses	dose	NNS
cord-312955-gs65c3fy	290	41	of	of	IN
cord-312955-gs65c3fy	290	42	8	8	CD
cord-312955-gs65c3fy	290	43	million	million	CD
cord-312955-gs65c3fy	290	44	international	international	JJ
cord-312955-gs65c3fy	290	45	units	unit	NNS
cord-312955-gs65c3fy	290	46	of	of	IN
cord-312955-gs65c3fy	290	47	IFNb	IFNb	NNS
cord-312955-gs65c3fy	290	48	,	,	,
cord-312955-gs65c3fy	290	49	while	while	IN
cord-312955-gs65c3fy	290	50	the	the	DT
cord-312955-gs65c3fy	290	51	control	control	NN
cord-312955-gs65c3fy	290	52	group	group	NN
cord-312955-gs65c3fy	290	53	of	of	IN
cord-312955-gs65c3fy	290	54	41	41	CD
cord-312955-gs65c3fy	290	55	patients	patient	NNS
cord-312955-gs65c3fy	290	56	were	be	VBD
cord-312955-gs65c3fy	290	57	given	give	VBN
cord-312955-gs65c3fy	290	58	all	all	PDT
cord-312955-gs65c3fy	290	59	the	the	DT
cord-312955-gs65c3fy	290	60	above	above	JJ
cord-312955-gs65c3fy	290	61	except	except	IN
cord-312955-gs65c3fy	290	62	IFNb	IFNb	NNS
cord-312955-gs65c3fy	290	63	.	.	.
cord-312955-gs65c3fy	291	1	The	the	DT
cord-312955-gs65c3fy	291	2	median	median	JJ
cord-312955-gs65c3fy	291	3	number	number	NN
cord-312955-gs65c3fy	291	4	of	of	IN
cord-312955-gs65c3fy	291	5	days	day	NNS
cord-312955-gs65c3fy	291	6	from	from	IN
cord-312955-gs65c3fy	291	7	symptom	symptom	NN
cord-312955-gs65c3fy	291	8	onset	onset	NN
cord-312955-gs65c3fy	291	9	to	to	TO
cord-312955-gs65c3fy	291	10	start	start	VB
cord-312955-gs65c3fy	291	11	of	of	IN
cord-312955-gs65c3fy	291	12	study	study	NN
cord-312955-gs65c3fy	291	13	treatment	treatment	NN
cord-312955-gs65c3fy	291	14	was	be	VBD
cord-312955-gs65c3fy	291	15	5	5	CD
cord-312955-gs65c3fy	291	16	days	day	NNS
cord-312955-gs65c3fy	291	17	.	.	.
cord-312955-gs65c3fy	292	1	Patients	patient	NNS
cord-312955-gs65c3fy	292	2	given	give	VBN
cord-312955-gs65c3fy	292	3	also	also	RB
cord-312955-gs65c3fy	292	4	IFNb	IFNb	VBZ
cord-312955-gs65c3fy	292	5	had	have	VBD
cord-312955-gs65c3fy	292	6	a	a	DT
cord-312955-gs65c3fy	292	7	significantly	significantly	RB
cord-312955-gs65c3fy	292	8	shorter	short	JJR
cord-312955-gs65c3fy	292	9	median	median	JJ
cord-312955-gs65c3fy	292	10	time	time	NN
cord-312955-gs65c3fy	292	11	from	from	IN
cord-312955-gs65c3fy	292	12	the	the	DT
cord-312955-gs65c3fy	292	13	start	start	NN
cord-312955-gs65c3fy	292	14	of	of	IN
cord-312955-gs65c3fy	292	15	treatment	treatment	NN
cord-312955-gs65c3fy	292	16	to	to	IN
cord-312955-gs65c3fy	292	17	negative	negative	JJ
cord-312955-gs65c3fy	292	18	nasopharyngeal	nasopharyngeal	JJ
cord-312955-gs65c3fy	292	19	swab	swab	NN
cord-312955-gs65c3fy	292	20	(	(	-LRB-
cord-312955-gs65c3fy	292	21	5	5	CD
cord-312955-gs65c3fy	292	22	-	-	SYM
cord-312955-gs65c3fy	292	23	11	11	CD
cord-312955-gs65c3fy	292	24	days	day	NNS
cord-312955-gs65c3fy	292	25	)	)	-RRB-
cord-312955-gs65c3fy	292	26	in	in	IN
cord-312955-gs65c3fy	292	27	comparison	comparison	NN
cord-312955-gs65c3fy	292	28	to	to	IN
cord-312955-gs65c3fy	292	29	the	the	DT
cord-312955-gs65c3fy	292	30	control	control	NN
cord-312955-gs65c3fy	292	31	group	group	NN
cord-312955-gs65c3fy	292	32	(	(	-LRB-
cord-312955-gs65c3fy	292	33	8	8	CD
cord-312955-gs65c3fy	292	34	-	-	SYM
cord-312955-gs65c3fy	292	35	15	15	CD
cord-312955-gs65c3fy	292	36	days	day	NNS
cord-312955-gs65c3fy	292	37	)	)	-RRB-
cord-312955-gs65c3fy	292	38	.	.	.
cord-312955-gs65c3fy	293	1	Moreover	moreover	RB
cord-312955-gs65c3fy	293	2	,	,	,
cord-312955-gs65c3fy	293	3	IFNb	IFNb	NNS
cord-312955-gs65c3fy	293	4	reduced	reduce	VBD
cord-312955-gs65c3fy	293	5	viral	viral	JJ
cord-312955-gs65c3fy	293	6	load	load	NN
cord-312955-gs65c3fy	293	7	and	and	CC
cord-312955-gs65c3fy	293	8	number	number	NN
cord-312955-gs65c3fy	293	9	of	of	IN
cord-312955-gs65c3fy	293	10	significantly	significantly	RB
cord-312955-gs65c3fy	293	11	ill	ill	JJ
cord-312955-gs65c3fy	293	12	patients	patient	NNS
cord-312955-gs65c3fy	293	13	relative	relative	JJ
cord-312955-gs65c3fy	293	14	to	to	IN
cord-312955-gs65c3fy	293	15	the	the	DT
cord-312955-gs65c3fy	293	16	control	control	NN
cord-312955-gs65c3fy	293	17	group	group	NN
cord-312955-gs65c3fy	293	18	,	,	,
cord-312955-gs65c3fy	293	19	this	this	DT
cord-312955-gs65c3fy	293	20	without	without	IN
cord-312955-gs65c3fy	293	21	significant	significant	JJ
cord-312955-gs65c3fy	293	22	side	side	NN
cord-312955-gs65c3fy	293	23	-	-	HYPH
cord-312955-gs65c3fy	293	24	effects	effect	NNS
cord-312955-gs65c3fy	293	25	(	(	-LRB-
cord-312955-gs65c3fy	293	26	110	110	CD
cord-312955-gs65c3fy	293	27	)	)	-RRB-
cord-312955-gs65c3fy	293	28	.	.	.
cord-312955-gs65c3fy	294	1	In	in	IN
cord-312955-gs65c3fy	294	2	a	a	DT
cord-312955-gs65c3fy	294	3	medical	medical	JJ
cord-312955-gs65c3fy	294	4	study	study	NN
cord-312955-gs65c3fy	294	5	on	on	IN
cord-312955-gs65c3fy	294	6	the	the	DT
cord-312955-gs65c3fy	294	7	effects	effect	NNS
cord-312955-gs65c3fy	294	8	of	of	IN
cord-312955-gs65c3fy	294	9	treatment	treatment	NN
cord-312955-gs65c3fy	294	10	with	with	IN
cord-312955-gs65c3fy	294	11	IFNa2b	ifna2b	NN
cord-312955-gs65c3fy	294	12	in	in	IN
cord-312955-gs65c3fy	294	13	a	a	DT
cord-312955-gs65c3fy	294	14	cohort	cohort	NN
cord-312955-gs65c3fy	294	15	of	of	IN
cord-312955-gs65c3fy	294	16	confirmed	confirm	VBN
cord-312955-gs65c3fy	294	17	COVID-19	covid-19	CD
cord-312955-gs65c3fy	294	18	patients	patient	NNS
cord-312955-gs65c3fy	294	19	,	,	,
cord-312955-gs65c3fy	294	20	some	some	DT
cord-312955-gs65c3fy	294	21	of	of	IN
cord-312955-gs65c3fy	294	22	the	the	DT
cord-312955-gs65c3fy	294	23	77	77	CD
cord-312955-gs65c3fy	294	24	participants	participant	NNS
cord-312955-gs65c3fy	294	25	were	be	VBD
cord-312955-gs65c3fy	294	26	given	give	VBN
cord-312955-gs65c3fy	294	27	nebulized	nebulize	VBN
cord-312955-gs65c3fy	294	28	IFNa2b	ifna2b	RB
cord-312955-gs65c3fy	294	29	with	with	IN
cord-312955-gs65c3fy	294	30	or	or	CC
cord-312955-gs65c3fy	294	31	without	without	IN
cord-312955-gs65c3fy	294	32	arbidol	arbidol	NN
cord-312955-gs65c3fy	294	33	while	while	IN
cord-312955-gs65c3fy	294	34	others	other	NNS
cord-312955-gs65c3fy	294	35	were	be	VBD
cord-312955-gs65c3fy	294	36	given	give	VBN
cord-312955-gs65c3fy	294	37	only	only	RB
cord-312955-gs65c3fy	294	38	arbidol	arbidol	NN
cord-312955-gs65c3fy	294	39	.	.	.
cord-312955-gs65c3fy	295	1	Treatment	treatment	NN
cord-312955-gs65c3fy	295	2	with	with	IN
cord-312955-gs65c3fy	295	3	IFNa2b	ifna2b	NN
cord-312955-gs65c3fy	295	4	with	with	IN
cord-312955-gs65c3fy	295	5	or	or	CC
cord-312955-gs65c3fy	295	6	without	without	IN
cord-312955-gs65c3fy	295	7	arbidol	arbidol	NN
cord-312955-gs65c3fy	295	8	reduced	reduce	VBD
cord-312955-gs65c3fy	295	9	the	the	DT
cord-312955-gs65c3fy	295	10	duration	duration	NN
cord-312955-gs65c3fy	295	11	of	of	IN
cord-312955-gs65c3fy	295	12	detectable	detectable	JJ
cord-312955-gs65c3fy	295	13	virus	virus	NN
cord-312955-gs65c3fy	295	14	in	in	IN
cord-312955-gs65c3fy	295	15	the	the	DT
cord-312955-gs65c3fy	295	16	upper	upper	JJ
cord-312955-gs65c3fy	295	17	respiratory	respiratory	JJ
cord-312955-gs65c3fy	295	18	tract	tract	NN
cord-312955-gs65c3fy	295	19	and	and	CC
cord-312955-gs65c3fy	295	20	reduced	reduced	JJ
cord-312955-gs65c3fy	295	21	duration	duration	NN
cord-312955-gs65c3fy	295	22	of	of	IN
cord-312955-gs65c3fy	295	23	elevated	elevated	JJ
cord-312955-gs65c3fy	295	24	blood	blood	NN
cord-312955-gs65c3fy	295	25	levels	level	NNS
cord-312955-gs65c3fy	295	26	of	of	IN
cord-312955-gs65c3fy	295	27	IL6	il6	NN
cord-312955-gs65c3fy	295	28	and	and	CC
cord-312955-gs65c3fy	295	29	c	c	NN
cord-312955-gs65c3fy	295	30	-	-	HYPH
cord-312955-gs65c3fy	295	31	reactive	reactive	JJ
cord-312955-gs65c3fy	295	32	protein	protein	NN
cord-312955-gs65c3fy	295	33	,	,	,
cord-312955-gs65c3fy	295	34	which	which	WDT
cord-312955-gs65c3fy	295	35	are	be	VBP
cord-312955-gs65c3fy	295	36	inflammatory	inflammatory	JJ
cord-312955-gs65c3fy	295	37	markers	marker	NNS
cord-312955-gs65c3fy	295	38	(	(	-LRB-
cord-312955-gs65c3fy	295	39	111	111	CD
cord-312955-gs65c3fy	295	40	)	)	-RRB-
cord-312955-gs65c3fy	295	41	.	.	.
cord-312955-gs65c3fy	296	1	While	while	IN
cord-312955-gs65c3fy	296	2	the	the	DT
cord-312955-gs65c3fy	296	3	study	study	NN
cord-312955-gs65c3fy	296	4	did	do	VBD
cord-312955-gs65c3fy	296	5	not	not	RB
cord-312955-gs65c3fy	296	6	include	include	VB
cord-312955-gs65c3fy	296	7	a	a	DT
cord-312955-gs65c3fy	296	8	standard	standard	JJ
cord-312955-gs65c3fy	296	9	care	care	NN
cord-312955-gs65c3fy	296	10	group	group	NN
cord-312955-gs65c3fy	296	11	,	,	,
cord-312955-gs65c3fy	296	12	and	and	CC
cord-312955-gs65c3fy	296	13	all	all	DT
cord-312955-gs65c3fy	296	14	patients	patient	NNS
cord-312955-gs65c3fy	296	15	recovered	recover	VBD
cord-312955-gs65c3fy	296	16	,	,	,
cord-312955-gs65c3fy	296	17	it	-PRON-	PRP
cord-312955-gs65c3fy	296	18	still	still	RB
cord-312955-gs65c3fy	296	19	provides	provide	VBZ
cord-312955-gs65c3fy	296	20	an	an	DT
cord-312955-gs65c3fy	296	21	indication	indication	NN
cord-312955-gs65c3fy	296	22	of	of	IN
cord-312955-gs65c3fy	296	23	IFN	IFN	NNP
cord-312955-gs65c3fy	296	24	-	-	HYPH
cord-312955-gs65c3fy	296	25	I	-PRON-	PRP
cord-312955-gs65c3fy	296	26	efficiency	efficiency	NN
cord-312955-gs65c3fy	296	27	.	.	.
cord-312955-gs65c3fy	297	1	The	the	DT
cord-312955-gs65c3fy	297	2	efficiency	efficiency	NN
cord-312955-gs65c3fy	297	3	of	of	IN
cord-312955-gs65c3fy	297	4	IFNb1a	IFNb1a	NNP
cord-312955-gs65c3fy	297	5	subcutaneously	subcutaneously	RB
cord-312955-gs65c3fy	297	6	injected	inject	VBD
cord-312955-gs65c3fy	297	7	three	three	CD
cord-312955-gs65c3fy	297	8	times	time	NNS
cord-312955-gs65c3fy	297	9	weekly	weekly	JJ
cord-312955-gs65c3fy	297	10	for	for	IN
cord-312955-gs65c3fy	297	11	2	2	CD
cord-312955-gs65c3fy	297	12	weeks	week	NNS
cord-312955-gs65c3fy	297	13	for	for	IN
cord-312955-gs65c3fy	297	14	treatment	treatment	NN
cord-312955-gs65c3fy	297	15	of	of	IN
cord-312955-gs65c3fy	297	16	severe	severe	JJ
cord-312955-gs65c3fy	297	17	COVID-19	covid-19	NN
cord-312955-gs65c3fy	297	18	was	be	VBD
cord-312955-gs65c3fy	297	19	tested	test	VBN
cord-312955-gs65c3fy	297	20	in	in	IN
cord-312955-gs65c3fy	297	21	a	a	DT
cord-312955-gs65c3fy	297	22	randomized	randomized	JJ
cord-312955-gs65c3fy	297	23	clinical	clinical	JJ
cord-312955-gs65c3fy	297	24	trial	trial	NN
cord-312955-gs65c3fy	297	25	.	.	.
cord-312955-gs65c3fy	298	1	All	all	PDT
cord-312955-gs65c3fy	298	2	the	the	DT
cord-312955-gs65c3fy	298	3	patients	patient	NNS
cord-312955-gs65c3fy	298	4	(	(	-LRB-
cord-312955-gs65c3fy	298	5	including	include	VBG
cord-312955-gs65c3fy	298	6	the	the	DT
cord-312955-gs65c3fy	298	7	control	control	NN
cord-312955-gs65c3fy	298	8	group	group	NN
cord-312955-gs65c3fy	298	9	)	)	-RRB-
cord-312955-gs65c3fy	298	10	received	receive	VBD
cord-312955-gs65c3fy	298	11	standard	standard	NN
cord-312955-gs65c3fy	298	12	of	of	IN
cord-312955-gs65c3fy	298	13	care	care	NN
cord-312955-gs65c3fy	298	14	,	,	,
cord-312955-gs65c3fy	298	15	including	include	VBG
cord-312955-gs65c3fy	298	16	a	a	DT
cord-312955-gs65c3fy	298	17	range	range	NN
cord-312955-gs65c3fy	298	18	of	of	IN
cord-312955-gs65c3fy	298	19	other	other	JJ
cord-312955-gs65c3fy	298	20	medicines	medicine	NNS
cord-312955-gs65c3fy	298	21	(	(	-LRB-
cord-312955-gs65c3fy	298	22	hydroxychloroquine	hydroxychloroquine	NNP
cord-312955-gs65c3fy	298	23	,	,	,
cord-312955-gs65c3fy	298	24	antibiotics	antibiotic	NNS
cord-312955-gs65c3fy	298	25	,	,	,
cord-312955-gs65c3fy	298	26	antiviral	antiviral	JJ
cord-312955-gs65c3fy	298	27	medicine	medicine	NN
cord-312955-gs65c3fy	298	28	and	and	CC
cord-312955-gs65c3fy	298	29	more	more	JJR
cord-312955-gs65c3fy	298	30	)	)	-RRB-
cord-312955-gs65c3fy	298	31	.	.	.
cord-312955-gs65c3fy	299	1	While	while	IN
cord-312955-gs65c3fy	299	2	the	the	DT
cord-312955-gs65c3fy	299	3	clinical	clinical	JJ
cord-312955-gs65c3fy	299	4	response	response	NN
cord-312955-gs65c3fy	299	5	was	be	VBD
cord-312955-gs65c3fy	299	6	not	not	RB
cord-312955-gs65c3fy	299	7	significantly	significantly	RB
cord-312955-gs65c3fy	299	8	different	different	JJ
cord-312955-gs65c3fy	299	9	between	between	IN
cord-312955-gs65c3fy	299	10	the	the	DT
cord-312955-gs65c3fy	299	11	IFNb1	ifnb1	NN
cord-312955-gs65c3fy	299	12	and	and	CC
cord-312955-gs65c3fy	299	13	the	the	DT
cord-312955-gs65c3fy	299	14	control	control	NN
cord-312955-gs65c3fy	299	15	groups	group	NNS
cord-312955-gs65c3fy	299	16	,	,	,
cord-312955-gs65c3fy	299	17	the	the	DT
cord-312955-gs65c3fy	299	18	28-day	28-day	CD
cord-312955-gs65c3fy	299	19	overall	overall	JJ
cord-312955-gs65c3fy	299	20	mortality	mortality	NN
cord-312955-gs65c3fy	299	21	was	be	VBD
cord-312955-gs65c3fy	299	22	significantly	significantly	RB
cord-312955-gs65c3fy	299	23	lower	low	JJR
cord-312955-gs65c3fy	299	24	(	(	-LRB-
cord-312955-gs65c3fy	299	25	19	19	CD
cord-312955-gs65c3fy	299	26	%	%	NN
cord-312955-gs65c3fy	299	27	vs.	vs.	IN
cord-312955-gs65c3fy	299	28	44	44	CD
cord-312955-gs65c3fy	299	29	%	%	NN
cord-312955-gs65c3fy	299	30	)	)	-RRB-
cord-312955-gs65c3fy	299	31	in	in	IN
cord-312955-gs65c3fy	299	32	the	the	DT
cord-312955-gs65c3fy	299	33	IFNb1	ifnb1	NN
cord-312955-gs65c3fy	299	34	treated	treat	VBN
cord-312955-gs65c3fy	299	35	group	group	NN
cord-312955-gs65c3fy	299	36	(	(	-LRB-
cord-312955-gs65c3fy	299	37	112	112	CD
cord-312955-gs65c3fy	299	38	)	)	-RRB-
cord-312955-gs65c3fy	299	39	.	.	.
cord-312955-gs65c3fy	300	1	In	in	IN
cord-312955-gs65c3fy	300	2	a	a	DT
cord-312955-gs65c3fy	300	3	retrospective	retrospective	JJ
cord-312955-gs65c3fy	300	4	study	study	NN
cord-312955-gs65c3fy	300	5	of	of	IN
cord-312955-gs65c3fy	300	6	patients	patient	NNS
cord-312955-gs65c3fy	300	7	receiving	receive	VBG
cord-312955-gs65c3fy	300	8	IFNa2	IFNa2	NNP
cord-312955-gs65c3fy	300	9	through	through	IN
cord-312955-gs65c3fy	300	10	inhalation	inhalation	NN
cord-312955-gs65c3fy	300	11	,	,	,
cord-312955-gs65c3fy	300	12	alone	alone	RB
cord-312955-gs65c3fy	300	13	or	or	CC
cord-312955-gs65c3fy	300	14	in	in	IN
cord-312955-gs65c3fy	300	15	combination	combination	NN
cord-312955-gs65c3fy	300	16	with	with	IN
cord-312955-gs65c3fy	300	17	other	other	JJ
cord-312955-gs65c3fy	300	18	drugs	drug	NNS
cord-312955-gs65c3fy	300	19	at	at	IN
cord-312955-gs65c3fy	300	20	a	a	DT
cord-312955-gs65c3fy	300	21	relative	relative	JJ
cord-312955-gs65c3fy	300	22	early	early	RB
cord-312955-gs65c3fy	300	23	versus	versus	IN
cord-312955-gs65c3fy	300	24	late	late	JJ
cord-312955-gs65c3fy	300	25	stage	stage	NN
cord-312955-gs65c3fy	300	26	of	of	IN
cord-312955-gs65c3fy	300	27	the	the	DT
cord-312955-gs65c3fy	300	28	infection	infection	NN
cord-312955-gs65c3fy	300	29	,	,	,
cord-312955-gs65c3fy	300	30	it	-PRON-	PRP
cord-312955-gs65c3fy	300	31	was	be	VBD
cord-312955-gs65c3fy	300	32	found	find	VBN
cord-312955-gs65c3fy	300	33	that	that	IN
cord-312955-gs65c3fy	300	34	those	those	DT
cord-312955-gs65c3fy	300	35	receiving	receive	VBG
cord-312955-gs65c3fy	300	36	IFNa2	ifna2	NN
cord-312955-gs65c3fy	300	37	at	at	IN
cord-312955-gs65c3fy	300	38	an	an	DT
cord-312955-gs65c3fy	300	39	early	early	JJ
cord-312955-gs65c3fy	300	40	stage	stage	NN
cord-312955-gs65c3fy	300	41	had	have	VBD
cord-312955-gs65c3fy	300	42	a	a	DT
cord-312955-gs65c3fy	300	43	significantly	significantly	RB
cord-312955-gs65c3fy	300	44	lower	low	JJR
cord-312955-gs65c3fy	300	45	rate	rate	NN
cord-312955-gs65c3fy	300	46	of	of	IN
cord-312955-gs65c3fy	300	47	mortality	mortality	NN
cord-312955-gs65c3fy	300	48	.	.	.
cord-312955-gs65c3fy	301	1	In	in	IN
cord-312955-gs65c3fy	301	2	contrast	contrast	NN
cord-312955-gs65c3fy	301	3	,	,	,
cord-312955-gs65c3fy	301	4	late	late	JJ
cord-312955-gs65c3fy	301	5	interferon	interferon	NN
cord-312955-gs65c3fy	301	6	therapy	therapy	NN
cord-312955-gs65c3fy	301	7	increased	increase	VBD
cord-312955-gs65c3fy	301	8	mortality	mortality	NN
cord-312955-gs65c3fy	301	9	and	and	CC
cord-312955-gs65c3fy	301	10	delayed	delay	VBN
cord-312955-gs65c3fy	301	11	recovery	recovery	NN
cord-312955-gs65c3fy	301	12	(	(	-LRB-
cord-312955-gs65c3fy	301	13	113	113	CD
cord-312955-gs65c3fy	301	14	)	)	-RRB-
cord-312955-gs65c3fy	301	15	.	.	.
cord-312955-gs65c3fy	302	1	The	the	DT
cord-312955-gs65c3fy	302	2	study	study	NN
cord-312955-gs65c3fy	302	3	suggests	suggest	VBZ
cord-312955-gs65c3fy	302	4	a	a	DT
cord-312955-gs65c3fy	302	5	relation	relation	NN
cord-312955-gs65c3fy	302	6	between	between	IN
cord-312955-gs65c3fy	302	7	the	the	DT
cord-312955-gs65c3fy	302	8	time	time	NN
cord-312955-gs65c3fy	302	9	of	of	IN
cord-312955-gs65c3fy	302	10	IFN	IFN	NNP
cord-312955-gs65c3fy	302	11	-	-	HYPH
cord-312955-gs65c3fy	302	12	I	I	NNP
cord-312955-gs65c3fy	302	13	treatment	treatment	NN
cord-312955-gs65c3fy	302	14	and	and	CC
cord-312955-gs65c3fy	302	15	its	-PRON-	PRP$
cord-312955-gs65c3fy	302	16	efficiency	efficiency	NN
cord-312955-gs65c3fy	302	17	.	.	.
cord-312955-gs65c3fy	303	1	Synairgen	Synairgen	NNP
cord-312955-gs65c3fy	303	2	,	,	,
cord-312955-gs65c3fy	303	3	a	a	DT
cord-312955-gs65c3fy	303	4	UK	UK	NNP
cord-312955-gs65c3fy	303	5	-	-	HYPH
cord-312955-gs65c3fy	303	6	based	base	VBN
cord-312955-gs65c3fy	303	7	company	company	NN
cord-312955-gs65c3fy	303	8	,	,	,
cord-312955-gs65c3fy	303	9	performed	perform	VBD
cord-312955-gs65c3fy	303	10	a	a	DT
cord-312955-gs65c3fy	303	11	controlled	control	VBN
cord-312955-gs65c3fy	303	12	clinical	clinical	JJ
cord-312955-gs65c3fy	303	13	trial	trial	NN
cord-312955-gs65c3fy	303	14	of	of	IN
cord-312955-gs65c3fy	303	15	inhaled	inhale	VBN
cord-312955-gs65c3fy	303	16	IFNb	IFNb	NNS
cord-312955-gs65c3fy	303	17	on	on	IN
cord-312955-gs65c3fy	303	18	221	221	CD
cord-312955-gs65c3fy	303	19	patients	patient	NNS
cord-312955-gs65c3fy	303	20	and	and	CC
cord-312955-gs65c3fy	303	21	reported	report	VBD
cord-312955-gs65c3fy	303	22	that	that	IN
cord-312955-gs65c3fy	303	23	compared	compare	VBN
cord-312955-gs65c3fy	303	24	with	with	IN
cord-312955-gs65c3fy	303	25	placebo	placebo	NN
cord-312955-gs65c3fy	303	26	the	the	DT
cord-312955-gs65c3fy	303	27	odds	odd	NNS
cord-312955-gs65c3fy	303	28	of	of	IN
cord-312955-gs65c3fy	303	29	developing	develop	VBG
cord-312955-gs65c3fy	303	30	severe	severe	JJ
cord-312955-gs65c3fy	303	31	disease	disease	NN
cord-312955-gs65c3fy	303	32	during	during	IN
cord-312955-gs65c3fy	303	33	the	the	DT
cord-312955-gs65c3fy	303	34	treatment	treatment	NN
cord-312955-gs65c3fy	303	35	period	period	NN
cord-312955-gs65c3fy	303	36	decreased	decrease	VBD
cord-312955-gs65c3fy	303	37	by	by	IN
cord-312955-gs65c3fy	303	38	79	79	CD
cord-312955-gs65c3fy	303	39	%	%	NN
cord-312955-gs65c3fy	303	40	for	for	IN
cord-312955-gs65c3fy	303	41	hospitalized	hospitalize	VBN
cord-312955-gs65c3fy	303	42	patients	patient	NNS
cord-312955-gs65c3fy	303	43	receiving	receive	VBG
cord-312955-gs65c3fy	303	44	SNG001	SNG001	NNP
cord-312955-gs65c3fy	303	45	,	,	,
cord-312955-gs65c3fy	303	46	and	and	CC
cord-312955-gs65c3fy	303	47	that	that	IN
cord-312955-gs65c3fy	303	48	patients	patient	NNS
cord-312955-gs65c3fy	303	49	who	who	WP
cord-312955-gs65c3fy	303	50	received	receive	VBD
cord-312955-gs65c3fy	303	51	SNG001	SNG001	NNP
cord-312955-gs65c3fy	303	52	were	be	VBD
cord-312955-gs65c3fy	303	53	more	more	JJR
cord-312955-gs65c3fy	303	54	than	than	IN
cord-312955-gs65c3fy	303	55	twice	twice	RB
cord-312955-gs65c3fy	303	56	as	as	RB
cord-312955-gs65c3fy	303	57	likely	likely	JJ
cord-312955-gs65c3fy	303	58	to	to	TO
cord-312955-gs65c3fy	303	59	recover	recover	VB
cord-312955-gs65c3fy	303	60	from	from	IN
cord-312955-gs65c3fy	303	61	the	the	DT
cord-312955-gs65c3fy	303	62	virus	virus	NN
cord-312955-gs65c3fy	303	63	during	during	IN
cord-312955-gs65c3fy	303	64	the	the	DT
cord-312955-gs65c3fy	303	65	treatment	treatment	NN
cord-312955-gs65c3fy	303	66	period	period	NN
cord-312955-gs65c3fy	303	67	versus	versus	IN
cord-312955-gs65c3fy	303	68	those	those	DT
cord-312955-gs65c3fy	303	69	randomized	randomize	VBN
cord-312955-gs65c3fy	303	70	to	to	IN
cord-312955-gs65c3fy	303	71	placebo	placebo	NN
cord-312955-gs65c3fy	303	72	.	.	.
cord-312955-gs65c3fy	304	1	These	these	DT
cord-312955-gs65c3fy	304	2	are	be	VBP
cord-312955-gs65c3fy	304	3	between	between	IN
cord-312955-gs65c3fy	304	4	the	the	DT
cord-312955-gs65c3fy	304	5	best	good	JJS
cord-312955-gs65c3fy	304	6	results	result	NNS
cord-312955-gs65c3fy	304	7	achieved	achieve	VBN
cord-312955-gs65c3fy	304	8	so	so	RB
cord-312955-gs65c3fy	304	9	far	far	RB
cord-312955-gs65c3fy	304	10	in	in	IN
cord-312955-gs65c3fy	304	11	curing	cure	VBG
cord-312955-gs65c3fy	304	12	COVID-19	covid-19	CD
cord-312955-gs65c3fy	304	13	.	.	.
cord-312955-gs65c3fy	305	1	More	More	JJR
cord-312955-gs65c3fy	305	2	clinical	clinical	JJ
cord-312955-gs65c3fy	305	3	trials	trial	NNS
cord-312955-gs65c3fy	305	4	are	be	VBP
cord-312955-gs65c3fy	305	5	now	now	RB
cord-312955-gs65c3fy	305	6	under	under	IN
cord-312955-gs65c3fy	305	7	way	way	NN
cord-312955-gs65c3fy	305	8	to	to	TO
cord-312955-gs65c3fy	305	9	evaluate	evaluate	VB
cord-312955-gs65c3fy	305	10	IFN	IFN	NNP
cord-312955-gs65c3fy	305	11	-	-	HYPH
cord-312955-gs65c3fy	305	12	I	-PRON-	PRP
cord-312955-gs65c3fy	305	13	efficiency	efficiency	NN
cord-312955-gs65c3fy	305	14	,	,	,
cord-312955-gs65c3fy	305	15	but	but	CC
cord-312955-gs65c3fy	305	16	clearly	clearly	RB
cord-312955-gs65c3fy	305	17	the	the	DT
cord-312955-gs65c3fy	305	18	initial	initial	JJ
cord-312955-gs65c3fy	305	19	trials	trial	NNS
cord-312955-gs65c3fy	305	20	have	have	VBP
cord-312955-gs65c3fy	305	21	been	be	VBN
cord-312955-gs65c3fy	305	22	encouraging	encourage	VBG
cord-312955-gs65c3fy	305	23	.	.	.
cord-312955-gs65c3fy	306	1	Moreover	moreover	RB
cord-312955-gs65c3fy	306	2	,	,	,
cord-312955-gs65c3fy	306	3	due	due	IN
cord-312955-gs65c3fy	306	4	to	to	IN
cord-312955-gs65c3fy	306	5	the	the	DT
cord-312955-gs65c3fy	306	6	many	many	JJ
cord-312955-gs65c3fy	306	7	years	year	NNS
cord-312955-gs65c3fy	306	8	of	of	IN
cord-312955-gs65c3fy	306	9	experience	experience	NN
cord-312955-gs65c3fy	306	10	in	in	IN
cord-312955-gs65c3fy	306	11	treating	treat	VBG
cord-312955-gs65c3fy	306	12	patients	patient	NNS
cord-312955-gs65c3fy	306	13	with	with	IN
cord-312955-gs65c3fy	306	14	IFN	IFN	NNP
cord-312955-gs65c3fy	306	15	-	-	HYPH
cord-312955-gs65c3fy	306	16	Is	be	VBZ
cord-312955-gs65c3fy	306	17	,	,	,
cord-312955-gs65c3fy	306	18	the	the	DT
cord-312955-gs65c3fy	306	19	availability	availability	NN
cord-312955-gs65c3fy	306	20	of	of	IN
cord-312955-gs65c3fy	306	21	the	the	DT
cord-312955-gs65c3fy	306	22	drug	drug	NN
cord-312955-gs65c3fy	306	23	and	and	CC
cord-312955-gs65c3fy	306	24	its	-PRON-	PRP$
cord-312955-gs65c3fy	306	25	relatively	relatively	RB
cord-312955-gs65c3fy	306	26	modest	modest	JJ
cord-312955-gs65c3fy	306	27	cost	cost	NN
cord-312955-gs65c3fy	306	28	make	make	VBP
cord-312955-gs65c3fy	306	29	it	-PRON-	PRP
cord-312955-gs65c3fy	306	30	an	an	DT
cord-312955-gs65c3fy	306	31	excellent	excellent	JJ
cord-312955-gs65c3fy	306	32	candidate	candidate	NN
cord-312955-gs65c3fy	306	33	for	for	IN
cord-312955-gs65c3fy	306	34	mass	mass	NN
cord-312955-gs65c3fy	306	35	treatment	treatment	NN
cord-312955-gs65c3fy	306	36	,	,	,
cord-312955-gs65c3fy	306	37	once	once	RB
cord-312955-gs65c3fy	306	38	approved	approve	VBN
cord-312955-gs65c3fy	306	39	.	.	.
cord-312955-gs65c3fy	307	1	However	however	RB
cord-312955-gs65c3fy	307	2	,	,	,
cord-312955-gs65c3fy	307	3	critical	critical	JJ
cord-312955-gs65c3fy	307	4	questions	question	NNS
cord-312955-gs65c3fy	307	5	remain	remain	VBP
cord-312955-gs65c3fy	307	6	concerning	concern	VBG
cord-312955-gs65c3fy	307	7	the	the	DT
cord-312955-gs65c3fy	307	8	use	use	NN
cord-312955-gs65c3fy	307	9	of	of	IN
cord-312955-gs65c3fy	307	10	IFN	IFN	NNP
cord-312955-gs65c3fy	307	11	-	-	,
cord-312955-gs65c3fy	307	12	Is	be	VBZ
cord-312955-gs65c3fy	307	13	for	for	IN
cord-312955-gs65c3fy	307	14	COVID-19	covid-19	JJ
cord-312955-gs65c3fy	307	15	and	and	CC
cord-312955-gs65c3fy	307	16	other	other	JJ
cord-312955-gs65c3fy	307	17	diseases	disease	NNS
cord-312955-gs65c3fy	307	18	(	(	-LRB-
cord-312955-gs65c3fy	307	19	Figure	figure	NN
cord-312955-gs65c3fy	307	20	4	4	CD
cord-312955-gs65c3fy	307	21	)	)	-RRB-
cord-312955-gs65c3fy	307	22	.	.	.
cord-312955-gs65c3fy	308	1	These	these	DT
cord-312955-gs65c3fy	308	2	questions	question	NNS
cord-312955-gs65c3fy	308	3	relate	relate	VBP
cord-312955-gs65c3fy	308	4	to	to	IN
cord-312955-gs65c3fy	308	5	the	the	DT
cord-312955-gs65c3fy	308	6	optimal	optimal	NN
cord-312955-gs65c3fy	309	1	IFN	IFN	NNP
cord-312955-gs65c3fy	309	2	-	-	HYPH
cord-312955-gs65c3fy	309	3	I	I	NNP
cord-312955-gs65c3fy	309	4	subtype	subtype	NN
cord-312955-gs65c3fy	309	5	,	,	,
cord-312955-gs65c3fy	309	6	drug	drug	NN
cord-312955-gs65c3fy	309	7	-	-	HYPH
cord-312955-gs65c3fy	309	8	concentration	concentration	NN
cord-312955-gs65c3fy	309	9	,	,	,
cord-312955-gs65c3fy	309	10	duration	duration	NN
cord-312955-gs65c3fy	309	11	of	of	IN
cord-312955-gs65c3fy	309	12	treatment	treatment	NN
cord-312955-gs65c3fy	309	13	,	,	,
cord-312955-gs65c3fy	309	14	mode	mode	NN
cord-312955-gs65c3fy	309	15	of	of	IN
cord-312955-gs65c3fy	309	16	treatment	treatment	NN
cord-312955-gs65c3fy	310	1	and	and	CC
cord-312955-gs65c3fy	310	2	at	at	IN
cord-312955-gs65c3fy	310	3	which	which	WDT
cord-312955-gs65c3fy	310	4	frequency	frequency	NN
cord-312955-gs65c3fy	310	5	should	should	MD
cord-312955-gs65c3fy	310	6	it	-PRON-	PRP
cord-312955-gs65c3fy	310	7	be	be	VB
cord-312955-gs65c3fy	310	8	given	give	VBN
cord-312955-gs65c3fy	310	9	.	.	.
cord-312955-gs65c3fy	311	1	Ample	ample	JJ
cord-312955-gs65c3fy	311	2	experience	experience	NN
cord-312955-gs65c3fy	311	3	exists	exist	VBZ
cord-312955-gs65c3fy	311	4	with	with	IN
cord-312955-gs65c3fy	311	5	subcutaneously	subcutaneously	RB
cord-312955-gs65c3fy	311	6	administration	administration	NN
cord-312955-gs65c3fy	311	7	,	,	,
cord-312955-gs65c3fy	311	8	which	which	WDT
cord-312955-gs65c3fy	311	9	is	be	VBZ
cord-312955-gs65c3fy	311	10	almost	almost	RB
cord-312955-gs65c3fy	311	11	the	the	DT
cord-312955-gs65c3fy	311	12	only	only	JJ
cord-312955-gs65c3fy	311	13	route	route	NN
cord-312955-gs65c3fy	311	14	IFN	IFN	NNP
cord-312955-gs65c3fy	311	15	-	-	:
cord-312955-gs65c3fy	311	16	Is	be	VBZ
cord-312955-gs65c3fy	311	17	were	be	VBD
cord-312955-gs65c3fy	311	18	used	use	VBN
cord-312955-gs65c3fy	311	19	in	in	IN
cord-312955-gs65c3fy	311	20	the	the	DT
cord-312955-gs65c3fy	311	21	clinic	clinic	NN
cord-312955-gs65c3fy	311	22	.	.	.
cord-312955-gs65c3fy	312	1	Here	here	RB
cord-312955-gs65c3fy	312	2	,	,	,
cord-312955-gs65c3fy	312	3	non	non	JJ
cord-312955-gs65c3fy	312	4	-	-	JJ
cord-312955-gs65c3fy	312	5	modified	modified	JJ
cord-312955-gs65c3fy	312	6	IFN	IFN	NNP
cord-312955-gs65c3fy	312	7	-	-	:
cord-312955-gs65c3fy	312	8	Is	be	VBZ
cord-312955-gs65c3fy	312	9	are	be	VBP
cord-312955-gs65c3fy	312	10	usually	usually	RB
cord-312955-gs65c3fy	312	11	administrated	administrate	VBN
cord-312955-gs65c3fy	312	12	two	two	CD
cord-312955-gs65c3fy	312	13	to	to	TO
cord-312955-gs65c3fy	312	14	three	three	CD
cord-312955-gs65c3fy	312	15	times	time	NNS
cord-312955-gs65c3fy	312	16	weekly	weekly	JJ
cord-312955-gs65c3fy	312	17	,	,	,
cord-312955-gs65c3fy	312	18	while	while	IN
cord-312955-gs65c3fy	312	19	PEGylated	pegylated	JJ
cord-312955-gs65c3fy	312	20	IFN	IFN	NNP
cord-312955-gs65c3fy	312	21	-	-	:
cord-312955-gs65c3fy	312	22	Is	be	VBZ
cord-312955-gs65c3fy	312	23	are	be	VBP
cord-312955-gs65c3fy	312	24	administrated	administrate	VBN
cord-312955-gs65c3fy	312	25	once	once	RB
cord-312955-gs65c3fy	312	26	per	per	IN
cord-312955-gs65c3fy	312	27	week	week	NN
cord-312955-gs65c3fy	312	28	or	or	CC
cord-312955-gs65c3fy	312	29	less	less	JJR
cord-312955-gs65c3fy	312	30	.	.	.
cord-312955-gs65c3fy	313	1	Injection	injection	NN
cord-312955-gs65c3fy	313	2	of	of	IN
cord-312955-gs65c3fy	313	3	IFN	IFN	NNP
cord-312955-gs65c3fy	313	4	-	-	:
cord-312955-gs65c3fy	313	5	Is	be	VBZ
cord-312955-gs65c3fy	313	6	will	will	MD
cord-312955-gs65c3fy	313	7	result	result	VB
cord-312955-gs65c3fy	313	8	in	in	IN
cord-312955-gs65c3fy	313	9	a	a	DT
cord-312955-gs65c3fy	313	10	systemic	systemic	JJ
cord-312955-gs65c3fy	313	11	response	response	NN
cord-312955-gs65c3fy	313	12	,	,	,
cord-312955-gs65c3fy	313	13	where	where	WRB
cord-312955-gs65c3fy	313	14	IFN	IFN	NNP
cord-312955-gs65c3fy	313	15	-	-	:
cord-312955-gs65c3fy	313	16	Is	be	VBZ
cord-312955-gs65c3fy	313	17	were	be	VBD
cord-312955-gs65c3fy	313	18	shown	show	VBN
cord-312955-gs65c3fy	313	19	to	to	TO
cord-312955-gs65c3fy	313	20	have	have	VB
cord-312955-gs65c3fy	313	21	antiviral	antiviral	JJ
cord-312955-gs65c3fy	313	22	functions	function	NNS
cord-312955-gs65c3fy	313	23	as	as	RB
cord-312955-gs65c3fy	313	24	well	well	RB
cord-312955-gs65c3fy	313	25	as	as	IN
cord-312955-gs65c3fy	313	26	pro	pro	JJ
cord-312955-gs65c3fy	313	27	and	and	CC
cord-312955-gs65c3fy	313	28	anti	anti	JJ
cord-312955-gs65c3fy	313	29	-	-	JJ
cord-312955-gs65c3fy	313	30	inflammatory	inflammatory	JJ
cord-312955-gs65c3fy	313	31	functions	function	NNS
cord-312955-gs65c3fy	313	32	.	.	.
cord-312955-gs65c3fy	314	1	Contrary	contrary	JJ
cord-312955-gs65c3fy	314	2	,	,	,
cord-312955-gs65c3fy	314	3	if	if	IN
cord-312955-gs65c3fy	314	4	given	give	VBN
cord-312955-gs65c3fy	314	5	by	by	IN
cord-312955-gs65c3fy	314	6	inhalation	inhalation	NN
cord-312955-gs65c3fy	314	7	,	,	,
cord-312955-gs65c3fy	314	8	it	-PRON-	PRP
cord-312955-gs65c3fy	314	9	will	will	MD
cord-312955-gs65c3fy	314	10	directly	directly	RB
cord-312955-gs65c3fy	314	11	target	target	VB
cord-312955-gs65c3fy	314	12	the	the	DT
cord-312955-gs65c3fy	314	13	epithelial	epithelial	NN
cord-312955-gs65c3fy	314	14	,	,	,
cord-312955-gs65c3fy	314	15	and	and	CC
cord-312955-gs65c3fy	314	16	thus	thus	RB
cord-312955-gs65c3fy	314	17	replace	replace	VB
cord-312955-gs65c3fy	314	18	the	the	DT
cord-312955-gs65c3fy	314	19	IFNb	IFNb	NNS
cord-312955-gs65c3fy	314	20	,	,	,
cord-312955-gs65c3fy	314	21	which	which	WDT
cord-312955-gs65c3fy	314	22	production	production	NN
cord-312955-gs65c3fy	314	23	is	be	VBZ
cord-312955-gs65c3fy	314	24	inhibited	inhibit	VBN
cord-312955-gs65c3fy	314	25	by	by	IN
cord-312955-gs65c3fy	314	26	the	the	DT
cord-312955-gs65c3fy	314	27	virus	virus	NN
cord-312955-gs65c3fy	314	28	.	.	.
cord-312955-gs65c3fy	315	1	Administration	administration	NN
cord-312955-gs65c3fy	315	2	as	as	IN
cord-312955-gs65c3fy	315	3	nasal	nasal	NN
cord-312955-gs65c3fy	315	4	drops	drop	NNS
cord-312955-gs65c3fy	315	5	of	of	IN
cord-312955-gs65c3fy	315	6	IFNa	IFNa	NNS
cord-312955-gs65c3fy	315	7	may	may	MD
cord-312955-gs65c3fy	315	8	be	be	VB
cord-312955-gs65c3fy	315	9	an	an	DT
cord-312955-gs65c3fy	315	10	excellent	excellent	JJ
cord-312955-gs65c3fy	315	11	prophylactic	prophylactic	JJ
cord-312955-gs65c3fy	315	12	method	method	NN
cord-312955-gs65c3fy	315	13	for	for	IN
cord-312955-gs65c3fy	315	14	people	people	NNS
cord-312955-gs65c3fy	315	15	at	at	IN
cord-312955-gs65c3fy	315	16	high	high	JJ
cord-312955-gs65c3fy	315	17	risk	risk	NN
cord-312955-gs65c3fy	315	18	.	.	.
cord-312955-gs65c3fy	316	1	Ideally	ideally	RB
cord-312955-gs65c3fy	316	2	,	,	,
cord-312955-gs65c3fy	316	3	these	these	DT
cord-312955-gs65c3fy	316	4	questions	question	NNS
cord-312955-gs65c3fy	316	5	could	could	MD
cord-312955-gs65c3fy	316	6	be	be	VB
cord-312955-gs65c3fy	316	7	answered	answer	VBN
cord-312955-gs65c3fy	316	8	using	use	VBG
cord-312955-gs65c3fy	316	9	animal	animal	NN
cord-312955-gs65c3fy	316	10	models	model	NNS
cord-312955-gs65c3fy	316	11	.	.	.
cord-312955-gs65c3fy	317	1	The	the	DT
cord-312955-gs65c3fy	317	2	problem	problem	NN
cord-312955-gs65c3fy	317	3	is	be	VBZ
cord-312955-gs65c3fy	317	4	that	that	IN
cord-312955-gs65c3fy	317	5	the	the	DT
cord-312955-gs65c3fy	317	6	disease	disease	NN
cord-312955-gs65c3fy	317	7	in	in	IN
cord-312955-gs65c3fy	317	8	those	those	DT
cord-312955-gs65c3fy	317	9	is	be	VBZ
cord-312955-gs65c3fy	317	10	not	not	RB
cord-312955-gs65c3fy	317	11	equivalent	equivalent	JJ
cord-312955-gs65c3fy	317	12	to	to	IN
cord-312955-gs65c3fy	317	13	that	that	DT
cord-312955-gs65c3fy	317	14	observed	observe	VBN
cord-312955-gs65c3fy	317	15	in	in	IN
cord-312955-gs65c3fy	317	16	humans	human	NNS
cord-312955-gs65c3fy	317	17	.	.	.
cord-312955-gs65c3fy	318	1	Due	due	IN
cord-312955-gs65c3fy	318	2	to	to	IN
cord-312955-gs65c3fy	318	3	the	the	DT
cord-312955-gs65c3fy	318	4	severity	severity	NN
cord-312955-gs65c3fy	318	5	of	of	IN
cord-312955-gs65c3fy	318	6	the	the	DT
cord-312955-gs65c3fy	318	7	disease	disease	NN
cord-312955-gs65c3fy	318	8	and	and	CC
cord-312955-gs65c3fy	318	9	the	the	DT
cord-312955-gs65c3fy	318	10	high	high	JJ
cord-312955-gs65c3fy	318	11	proven	prove	VBN
cord-312955-gs65c3fy	318	12	safety	safety	NN
cord-312955-gs65c3fy	318	13	of	of	IN
cord-312955-gs65c3fy	318	14	IFN	IFN	NNP
cord-312955-gs65c3fy	318	15	-	-	HYPH
cord-312955-gs65c3fy	318	16	Is	be	VBZ
cord-312955-gs65c3fy	318	17	,	,	,
cord-312955-gs65c3fy	318	18	more	more	RBR
cord-312955-gs65c3fy	318	19	clinical	clinical	JJ
cord-312955-gs65c3fy	318	20	trials	trial	NNS
cord-312955-gs65c3fy	318	21	on	on	IN
cord-312955-gs65c3fy	318	22	humans	human	NNS
cord-312955-gs65c3fy	318	23	,	,	,
cord-312955-gs65c3fy	318	24	testing	test	VBG
cord-312955-gs65c3fy	318	25	the	the	DT
cord-312955-gs65c3fy	318	26	many	many	JJ
cord-312955-gs65c3fy	318	27	open	open	JJ
cord-312955-gs65c3fy	318	28	questions	question	NNS
cord-312955-gs65c3fy	318	29	related	relate	VBN
cord-312955-gs65c3fy	318	30	to	to	IN
cord-312955-gs65c3fy	318	31	its	-PRON-	PRP$
cord-312955-gs65c3fy	318	32	best	good	JJS
cord-312955-gs65c3fy	318	33	mode	mode	NN
cord-312955-gs65c3fy	318	34	of	of	IN
cord-312955-gs65c3fy	318	35	administration	administration	NN
cord-312955-gs65c3fy	318	36	may	may	MD
cord-312955-gs65c3fy	318	37	be	be	VB
cord-312955-gs65c3fy	318	38	the	the	DT
cord-312955-gs65c3fy	318	39	fastest	fast	JJS
cord-312955-gs65c3fy	318	40	way	way	NN
cord-312955-gs65c3fy	318	41	forwards	forwards	RB
cord-312955-gs65c3fy	318	42	.	.	.
cord-312955-gs65c3fy	319	1	The	the	DT
cord-312955-gs65c3fy	319	2	subtype	subtype	NN
cord-312955-gs65c3fy	319	3	to	to	TO
cord-312955-gs65c3fy	319	4	use	use	VB
cord-312955-gs65c3fy	319	5	is	be	VBZ
cord-312955-gs65c3fy	319	6	another	another	DT
cord-312955-gs65c3fy	319	7	important	important	JJ
cord-312955-gs65c3fy	319	8	question	question	NN
cord-312955-gs65c3fy	319	9	.	.	.
cord-312955-gs65c3fy	320	1	For	for	IN
cord-312955-gs65c3fy	320	2	multiple	multiple	JJ
cord-312955-gs65c3fy	320	3	-	-	HYPH
cord-312955-gs65c3fy	320	4	sclerosis	sclerosis	NN
cord-312955-gs65c3fy	320	5	,	,	,
cord-312955-gs65c3fy	320	6	IFNb	IFNb	NNS
cord-312955-gs65c3fy	320	7	has	have	VBZ
cord-312955-gs65c3fy	320	8	been	be	VBN
cord-312955-gs65c3fy	320	9	used	use	VBN
cord-312955-gs65c3fy	320	10	for	for	IN
cord-312955-gs65c3fy	320	11	many	many	JJ
cord-312955-gs65c3fy	320	12	years	year	NNS
cord-312955-gs65c3fy	320	13	(	(	-LRB-
cord-312955-gs65c3fy	320	14	114	114	CD
cord-312955-gs65c3fy	320	15	)	)	-RRB-
cord-312955-gs65c3fy	320	16	,	,	,
cord-312955-gs65c3fy	320	17	as	as	IN
cord-312955-gs65c3fy	320	18	it	-PRON-	PRP
cord-312955-gs65c3fy	320	19	seems	seem	VBZ
cord-312955-gs65c3fy	320	20	to	to	TO
cord-312955-gs65c3fy	320	21	provide	provide	VB
cord-312955-gs65c3fy	320	22	a	a	DT
cord-312955-gs65c3fy	320	23	better	well	JJR
cord-312955-gs65c3fy	320	24	anti	anti	JJ
cord-312955-gs65c3fy	320	25	-	-	JJ
cord-312955-gs65c3fy	320	26	inflammatory	inflammatory	JJ
cord-312955-gs65c3fy	320	27	response	response	NN
cord-312955-gs65c3fy	320	28	than	than	IN
cord-312955-gs65c3fy	320	29	IFNas	IFNas	NNP
cord-312955-gs65c3fy	320	30	.	.	.
cord-312955-gs65c3fy	321	1	This	this	DT
cord-312955-gs65c3fy	321	2	may	may	MD
cord-312955-gs65c3fy	321	3	relate	relate	VB
cord-312955-gs65c3fy	321	4	to	to	IN
cord-312955-gs65c3fy	321	5	its	-PRON-	PRP$
cord-312955-gs65c3fy	321	6	higher	high	JJR
cord-312955-gs65c3fy	321	7	binding	bind	VBG
cord-312955-gs65c3fy	321	8	affinity	affinity	NN
cord-312955-gs65c3fy	321	9	to	to	IN
cord-312955-gs65c3fy	321	10	the	the	DT
cord-312955-gs65c3fy	321	11	interferon	interferon	NN
cord-312955-gs65c3fy	321	12	receptors	receptor	NNS
cord-312955-gs65c3fy	321	13	,	,	,
cord-312955-gs65c3fy	321	14	as	as	IN
cord-312955-gs65c3fy	321	15	has	have	VBZ
cord-312955-gs65c3fy	321	16	been	be	VBN
cord-312955-gs65c3fy	321	17	demonstrated	demonstrate	VBN
cord-312955-gs65c3fy	321	18	using	use	VBG
cord-312955-gs65c3fy	321	19	a	a	DT
cord-312955-gs65c3fy	321	20	tight	tight	JJ
cord-312955-gs65c3fy	321	21	binding	bind	VBG
cord-312955-gs65c3fy	321	22	IFNa	IFNa	NNS
cord-312955-gs65c3fy	321	23	mutant	mutant	JJ
cord-312955-gs65c3fy	321	24	(	(	-LRB-
cord-312955-gs65c3fy	321	25	YNS	YNS	NNP
cord-312955-gs65c3fy	321	26	-	-	HYPH
cord-312955-gs65c3fy	321	27	a8	a8	NNP
cord-312955-gs65c3fy	321	28	tail	tail	NN
cord-312955-gs65c3fy	321	29	)	)	-RRB-
cord-312955-gs65c3fy	321	30	,	,	,
cord-312955-gs65c3fy	321	31	which	which	WDT
cord-312955-gs65c3fy	321	32	binding	bind	VBG
cord-312955-gs65c3fy	321	33	affinity	affinity	NN
cord-312955-gs65c3fy	321	34	even	even	RB
cord-312955-gs65c3fy	321	35	surpasses	surpass	VBZ
cord-312955-gs65c3fy	321	36	that	that	DT
cord-312955-gs65c3fy	321	37	of	of	IN
cord-312955-gs65c3fy	321	38	IFNb	IFNb	NNS
cord-312955-gs65c3fy	321	39	[	[	-LRB-
cord-312955-gs65c3fy	321	40	see	see	VB
cord-312955-gs65c3fy	321	41	above	above	RB
cord-312955-gs65c3fy	321	42	(	(	-LRB-
cord-312955-gs65c3fy	321	43	57	57	CD
cord-312955-gs65c3fy	321	44	)	)	-RRB-
cord-312955-gs65c3fy	321	45	]	]	-RRB-
cord-312955-gs65c3fy	321	46	.	.	.
cord-312955-gs65c3fy	322	1	For	for	IN
cord-312955-gs65c3fy	322	2	combating	combat	VBG
cord-312955-gs65c3fy	322	3	viral	viral	JJ
cord-312955-gs65c3fy	322	4	disease	disease	NN
cord-312955-gs65c3fy	322	5	,	,	,
cord-312955-gs65c3fy	322	6	most	most	RBS
cord-312955-gs65c3fy	322	7	notable	notable	JJ
cord-312955-gs65c3fy	322	8	hepatitis	hepatitis	NN
cord-312955-gs65c3fy	322	9	C	C	NNP
cord-312955-gs65c3fy	322	10	,	,	,
cord-312955-gs65c3fy	322	11	IFNa2	IFNa2	NNP
cord-312955-gs65c3fy	322	12	has	have	VBZ
cord-312955-gs65c3fy	322	13	been	be	VBN
cord-312955-gs65c3fy	322	14	most	most	RBS
cord-312955-gs65c3fy	322	15	commonly	commonly	RB
cord-312955-gs65c3fy	322	16	used	use	VBN
cord-312955-gs65c3fy	322	17	(	(	-LRB-
cord-312955-gs65c3fy	322	18	115	115	CD
cord-312955-gs65c3fy	322	19	)	)	-RRB-
cord-312955-gs65c3fy	322	20	,	,	,
cord-312955-gs65c3fy	322	21	which	which	WDT
cord-312955-gs65c3fy	322	22	was	be	VBD
cord-312955-gs65c3fy	322	23	later	later	RB
cord-312955-gs65c3fy	322	24	replaced	replace	VBN
cord-312955-gs65c3fy	322	25	by	by	IN
cord-312955-gs65c3fy	322	26	PEGylated	pegylated	JJ
cord-312955-gs65c3fy	322	27	(	(	-LRB-
cord-312955-gs65c3fy	322	28	long	long	JJ
cord-312955-gs65c3fy	322	29	plasma	plasma	NN
cord-312955-gs65c3fy	322	30	half	half	JJ
cord-312955-gs65c3fy	322	31	-	-	HYPH
cord-312955-gs65c3fy	322	32	life	life	NN
cord-312955-gs65c3fy	322	33	)	)	-RRB-
cord-312955-gs65c3fy	323	1	IFNa2	IFNa2	NNP
cord-312955-gs65c3fy	323	2	(	(	-LRB-
cord-312955-gs65c3fy	323	3	116	116	CD
cord-312955-gs65c3fy	323	4	)	)	-RRB-
cord-312955-gs65c3fy	323	5	.	.	.
cord-312955-gs65c3fy	324	1	Also	also	RB
cord-312955-gs65c3fy	324	2	,	,	,
cord-312955-gs65c3fy	324	3	for	for	IN
cord-312955-gs65c3fy	324	4	cancers	cancer	NNS
cord-312955-gs65c3fy	325	1	IFNas	IFNas	NNP
cord-312955-gs65c3fy	325	2	were	be	VBD
cord-312955-gs65c3fy	325	3	mostly	mostly	RB
cord-312955-gs65c3fy	325	4	used	use	VBN
cord-312955-gs65c3fy	325	5	(	(	-LRB-
cord-312955-gs65c3fy	325	6	117	117	CD
cord-312955-gs65c3fy	325	7	)	)	-RRB-
cord-312955-gs65c3fy	325	8	.	.	.
cord-312955-gs65c3fy	326	1	A	a	DT
cord-312955-gs65c3fy	326	2	good	good	JJ
cord-312955-gs65c3fy	326	3	clinical	clinical	JJ
cord-312955-gs65c3fy	326	4	explanation	explanation	NN
cord-312955-gs65c3fy	326	5	of	of	IN
cord-312955-gs65c3fy	326	6	why	why	WRB
cord-312955-gs65c3fy	326	7	specific	specific	JJ
cord-312955-gs65c3fy	326	8	IFN	IFN	NNP
cord-312955-gs65c3fy	326	9	-	-	HYPH
cord-312955-gs65c3fy	326	10	I	-PRON-	PRP
cord-312955-gs65c3fy	326	11	subtypes	subtype	NNS
cord-312955-gs65c3fy	326	12	were	be	VBD
cord-312955-gs65c3fy	326	13	used	use	VBN
cord-312955-gs65c3fy	326	14	is	be	VBZ
cord-312955-gs65c3fy	326	15	often	often	RB
cord-312955-gs65c3fy	326	16	missing	miss	VBG
cord-312955-gs65c3fy	326	17	,	,	,
cord-312955-gs65c3fy	326	18	and	and	CC
cord-312955-gs65c3fy	326	19	decisions	decision	NNS
cord-312955-gs65c3fy	326	20	of	of	IN
cord-312955-gs65c3fy	326	21	which	which	WDT
cord-312955-gs65c3fy	326	22	interferon	interferon	NN
cord-312955-gs65c3fy	326	23	to	to	TO
cord-312955-gs65c3fy	326	24	use	use	VB
cord-312955-gs65c3fy	326	25	may	may	MD
cord-312955-gs65c3fy	326	26	often	often	RB
cord-312955-gs65c3fy	326	27	relate	relate	VB
cord-312955-gs65c3fy	326	28	to	to	IN
cord-312955-gs65c3fy	326	29	availability	availability	NN
cord-312955-gs65c3fy	326	30	rather	rather	RB
cord-312955-gs65c3fy	326	31	than	than	IN
cord-312955-gs65c3fy	326	32	to	to	IN
cord-312955-gs65c3fy	326	33	efficacy	efficacy	NN
cord-312955-gs65c3fy	326	34	.	.	.
cord-312955-gs65c3fy	327	1	Moreover	moreover	RB
cord-312955-gs65c3fy	327	2	,	,	,
cord-312955-gs65c3fy	327	3	due	due	IN
cord-312955-gs65c3fy	327	4	to	to	IN
cord-312955-gs65c3fy	327	5	the	the	DT
cord-312955-gs65c3fy	327	6	specie	specie	NN
cord-312955-gs65c3fy	327	7	specificity	specificity	NN
cord-312955-gs65c3fy	327	8	of	of	IN
cord-312955-gs65c3fy	327	9	IFN	IFN	NNP
cord-312955-gs65c3fy	327	10	-	-	HYPH
cord-312955-gs65c3fy	327	11	Is	be	VBZ
cord-312955-gs65c3fy	327	12	,	,	,
cord-312955-gs65c3fy	327	13	one	one	PRP
cord-312955-gs65c3fy	327	14	can	can	MD
cord-312955-gs65c3fy	327	15	not	not	RB
cord-312955-gs65c3fy	327	16	deduce	deduce	VB
cord-312955-gs65c3fy	327	17	from	from	IN
cord-312955-gs65c3fy	327	18	mouse	mouse	NN
cord-312955-gs65c3fy	327	19	experiments	experiment	NNS
cord-312955-gs65c3fy	327	20	,	,	,
cord-312955-gs65c3fy	327	21	which	which	WDT
cord-312955-gs65c3fy	327	22	IFN	IFN	NNP
cord-312955-gs65c3fy	327	23	-	-	HYPH
cord-312955-gs65c3fy	327	24	I	I	NNP
cord-312955-gs65c3fy	327	25	to	to	TO
cord-312955-gs65c3fy	327	26	use	use	VB
cord-312955-gs65c3fy	327	27	in	in	IN
cord-312955-gs65c3fy	327	28	humans	human	NNS
cord-312955-gs65c3fy	327	29	,	,	,
cord-312955-gs65c3fy	327	30	as	as	IN
cord-312955-gs65c3fy	327	31	the	the	DT
cord-312955-gs65c3fy	327	32	data	datum	NNS
cord-312955-gs65c3fy	327	33	are	be	VBP
cord-312955-gs65c3fy	327	34	not	not	RB
cord-312955-gs65c3fy	327	35	transferable	transferable	JJ
cord-312955-gs65c3fy	327	36	(	(	-LRB-
cord-312955-gs65c3fy	327	37	57	57	CD
cord-312955-gs65c3fy	327	38	,	,	,
cord-312955-gs65c3fy	327	39	118	118	CD
cord-312955-gs65c3fy	327	40	)	)	-RRB-
cord-312955-gs65c3fy	327	41	.	.	.
cord-312955-gs65c3fy	328	1	The	the	DT
cord-312955-gs65c3fy	328	2	main	main	JJ
cord-312955-gs65c3fy	328	3	difference	difference	NN
cord-312955-gs65c3fy	328	4	between	between	IN
cord-312955-gs65c3fy	328	5	IFNas	IFNas	NNP
cord-312955-gs65c3fy	328	6	and	and	CC
cord-312955-gs65c3fy	328	7	IFNb	IFNb	NNPS
cord-312955-gs65c3fy	328	8	is	be	VBZ
cord-312955-gs65c3fy	328	9	that	that	IN
cord-312955-gs65c3fy	328	10	the	the	DT
cord-312955-gs65c3fy	328	11	later	later	RB
cord-312955-gs65c3fy	328	12	has	have	VBZ
cord-312955-gs65c3fy	328	13	a	a	DT
cord-312955-gs65c3fy	328	14	stronger	strong	JJR
cord-312955-gs65c3fy	328	15	potency	potency	NN
cord-312955-gs65c3fy	328	16	to	to	TO
cord-312955-gs65c3fy	328	17	induce	induce	VB
cord-312955-gs65c3fy	328	18	antiproliferative	antiproliferative	JJ
cord-312955-gs65c3fy	328	19	and	and	CC
cord-312955-gs65c3fy	328	20	immunomodulatory	immunomodulatory	JJ
cord-312955-gs65c3fy	328	21	responses	response	NNS
cord-312955-gs65c3fy	328	22	(	(	-LRB-
cord-312955-gs65c3fy	328	23	tunable	tunable	JJ
cord-312955-gs65c3fy	328	24	)	)	-RRB-
cord-312955-gs65c3fy	328	25	,	,	,
cord-312955-gs65c3fy	328	26	while	while	IN
cord-312955-gs65c3fy	328	27	IFNa	IFNa	NNS
cord-312955-gs65c3fy	328	28	will	will	MD
cord-312955-gs65c3fy	328	29	provide	provide	VB
cord-312955-gs65c3fy	328	30	a	a	DT
cord-312955-gs65c3fy	328	31	cleaner	clean	JJR
cord-312955-gs65c3fy	328	32	antiviral	antiviral	JJ
cord-312955-gs65c3fy	328	33	response	response	NN
cord-312955-gs65c3fy	328	34	(	(	-LRB-
cord-312955-gs65c3fy	328	35	robust	robust	JJ
cord-312955-gs65c3fy	328	36	)	)	-RRB-
cord-312955-gs65c3fy	328	37	without	without	IN
cord-312955-gs65c3fy	328	38	the	the	DT
cord-312955-gs65c3fy	328	39	additional	additional	JJ
cord-312955-gs65c3fy	328	40	responses	response	NNS
cord-312955-gs65c3fy	328	41	associated	associate	VBN
cord-312955-gs65c3fy	328	42	with	with	IN
cord-312955-gs65c3fy	328	43	IFNb	IFNb	NNS
cord-312955-gs65c3fy	328	44	.	.	.
cord-312955-gs65c3fy	329	1	The	the	DT
cord-312955-gs65c3fy	329	2	open	open	JJ
cord-312955-gs65c3fy	329	3	question	question	NN
cord-312955-gs65c3fy	329	4	is	be	VBZ
cord-312955-gs65c3fy	329	5	which	which	WDT
cord-312955-gs65c3fy	329	6	is	be	VBZ
cord-312955-gs65c3fy	329	7	desired	desire	VBN
cord-312955-gs65c3fy	329	8	for	for	IN
cord-312955-gs65c3fy	329	9	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	329	10	treatment	treatment	NN
cord-312955-gs65c3fy	329	11	,	,	,
cord-312955-gs65c3fy	329	12	where	where	WRB
cord-312955-gs65c3fy	329	13	complications	complication	NNS
cord-312955-gs65c3fy	329	14	arise	arise	VBP
cord-312955-gs65c3fy	329	15	from	from	IN
cord-312955-gs65c3fy	329	16	the	the	DT
cord-312955-gs65c3fy	329	17	exuberated	exuberate	VBN
cord-312955-gs65c3fy	329	18	immune	immune	JJ
cord-312955-gs65c3fy	329	19	response	response	NN
cord-312955-gs65c3fy	329	20	.	.	.
cord-312955-gs65c3fy	330	1	Another	another	DT
cord-312955-gs65c3fy	330	2	,	,	,
cord-312955-gs65c3fy	330	3	important	important	JJ
cord-312955-gs65c3fy	330	4	parameter	parameter	NN
cord-312955-gs65c3fy	330	5	is	be	VBZ
cord-312955-gs65c3fy	330	6	the	the	DT
cord-312955-gs65c3fy	330	7	time	time	NN
cord-312955-gs65c3fy	330	8	of	of	IN
cord-312955-gs65c3fy	330	9	intervention	intervention	NN
cord-312955-gs65c3fy	330	10	by	by	IN
cord-312955-gs65c3fy	330	11	IFN	IFN	NNP
cord-312955-gs65c3fy	330	12	-	-	HYPH
cord-312955-gs65c3fy	330	13	I	I	NNP
cord-312955-gs65c3fy	330	14	,	,	,
cord-312955-gs65c3fy	330	15	in	in	IN
cord-312955-gs65c3fy	330	16	early	early	JJ
cord-312955-gs65c3fy	330	17	or	or	CC
cord-312955-gs65c3fy	330	18	late	late	JJ
cord-312955-gs65c3fy	330	19	-	-	HYPH
cord-312955-gs65c3fy	330	20	stage	stage	NN
cord-312955-gs65c3fy	330	21	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	330	22	disease	disease	NN
cord-312955-gs65c3fy	330	23	.	.	.
cord-312955-gs65c3fy	331	1	In	in	IN
cord-312955-gs65c3fy	331	2	a	a	DT
cord-312955-gs65c3fy	331	3	recent	recent	JJ
cord-312955-gs65c3fy	331	4	study	study	NN
cord-312955-gs65c3fy	331	5	in	in	IN
cord-312955-gs65c3fy	331	6	mice	mouse	NNS
cord-312955-gs65c3fy	331	7	it	-PRON-	PRP
cord-312955-gs65c3fy	331	8	has	have	VBZ
cord-312955-gs65c3fy	331	9	been	be	VBN
cord-312955-gs65c3fy	331	10	shown	show	VBN
cord-312955-gs65c3fy	331	11	that	that	IN
cord-312955-gs65c3fy	331	12	prolonged	prolong	VBN
cord-312955-gs65c3fy	331	13	IFN	IFN	NNP
cord-312955-gs65c3fy	331	14	-	-	HYPH
cord-312955-gs65c3fy	331	15	I	I	NNP
cord-312955-gs65c3fy	331	16	and	and	CC
cord-312955-gs65c3fy	331	17	III	III	NNP
cord-312955-gs65c3fy	331	18	signaling	signaling	NN
cord-312955-gs65c3fy	331	19	interferes	interfere	VBZ
cord-312955-gs65c3fy	331	20	with	with	IN
cord-312955-gs65c3fy	331	21	lung	lung	NN
cord-312955-gs65c3fy	331	22	repair	repair	NN
cord-312955-gs65c3fy	331	23	during	during	IN
cord-312955-gs65c3fy	331	24	influenza	influenza	NN
cord-312955-gs65c3fy	331	25	recovery	recovery	NN
cord-312955-gs65c3fy	331	26	,	,	,
cord-312955-gs65c3fy	331	27	probably	probably	RB
cord-312955-gs65c3fy	331	28	through	through	IN
cord-312955-gs65c3fy	331	29	p53	p53	NN
cord-312955-gs65c3fy	331	30	induction	induction	NN
cord-312955-gs65c3fy	331	31	,	,	,
cord-312955-gs65c3fy	331	32	which	which	WDT
cord-312955-gs65c3fy	331	33	reduces	reduce	VBZ
cord-312955-gs65c3fy	331	34	epithelial	epithelial	JJ
cord-312955-gs65c3fy	331	35	proliferation	proliferation	NN
cord-312955-gs65c3fy	331	36	and	and	CC
cord-312955-gs65c3fy	331	37	healing	healing	NN
cord-312955-gs65c3fy	331	38	,	,	,
cord-312955-gs65c3fy	331	39	while	while	IN
cord-312955-gs65c3fy	331	40	early	early	JJ
cord-312955-gs65c3fy	331	41	treatment	treatment	NN
cord-312955-gs65c3fy	331	42	protects	protect	VBZ
cord-312955-gs65c3fy	331	43	mice	mouse	NNS
cord-312955-gs65c3fy	331	44	(	(	-LRB-
cord-312955-gs65c3fy	331	45	119	119	CD
cord-312955-gs65c3fy	331	46	)	)	-RRB-
cord-312955-gs65c3fy	331	47	.	.	.
cord-312955-gs65c3fy	332	1	In	in	IN
cord-312955-gs65c3fy	332	2	SARS	SARS	NNP
cord-312955-gs65c3fy	332	3	-	-	:
cord-312955-gs65c3fy	332	4	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	332	5	this	this	DT
cord-312955-gs65c3fy	332	6	is	be	VBZ
cord-312955-gs65c3fy	332	7	further	further	RB
cord-312955-gs65c3fy	332	8	complicated	complicate	VBN
cord-312955-gs65c3fy	332	9	by	by	IN
cord-312955-gs65c3fy	332	10	the	the	DT
cord-312955-gs65c3fy	332	11	"	"	``
cord-312955-gs65c3fy	332	12	cytokine	cytokine	NN
cord-312955-gs65c3fy	332	13	-	-	HYPH
cord-312955-gs65c3fy	332	14	storm	storm	NN
cord-312955-gs65c3fy	332	15	"	"	''
cord-312955-gs65c3fy	332	16	symptoms	symptom	NNS
cord-312955-gs65c3fy	332	17	of	of	IN
cord-312955-gs65c3fy	332	18	severe	severe	JJ
cord-312955-gs65c3fy	332	19	COVID-19	covid-19	NN
cord-312955-gs65c3fy	332	20	,	,	,
cord-312955-gs65c3fy	332	21	as	as	IN
cord-312955-gs65c3fy	332	22	indicated	indicate	VBN
cord-312955-gs65c3fy	332	23	by	by	IN
cord-312955-gs65c3fy	332	24	elevated	elevated	JJ
cord-312955-gs65c3fy	332	25	IL6	IL6	NNP
cord-312955-gs65c3fy	332	26	and	and	CC
cord-312955-gs65c3fy	332	27	TNF	TNF	NNP
cord-312955-gs65c3fy	332	28	-	-	HYPH
cord-312955-gs65c3fy	332	29	alpha	alpha	NN
cord-312955-gs65c3fy	332	30	levels	level	NNS
cord-312955-gs65c3fy	332	31	.	.	.
cord-312955-gs65c3fy	333	1	Whether	whether	IN
cord-312955-gs65c3fy	333	2	IFN	IFN	NNP
cord-312955-gs65c3fy	333	3	-	-	HYPH
cord-312955-gs65c3fy	333	4	administration	administration	NN
cord-312955-gs65c3fy	333	5	,	,	,
cord-312955-gs65c3fy	333	6	particularly	particularly	RB
cord-312955-gs65c3fy	333	7	IFNb	IFNb	VBZ
cord-312955-gs65c3fy	333	8	suppresses	suppress	VBZ
cord-312955-gs65c3fy	333	9	or	or	CC
cord-312955-gs65c3fy	333	10	exacerbate	exacerbate	VB
cord-312955-gs65c3fy	333	11	the	the	DT
cord-312955-gs65c3fy	333	12	SARS	SARS	NNP
cord-312955-gs65c3fy	333	13	-	-	HYPH
cord-312955-gs65c3fy	333	14	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	333	15	cytokine	cytokine	NN
cord-312955-gs65c3fy	333	16	storm	storm	NN
cord-312955-gs65c3fy	333	17	needs	need	VBZ
cord-312955-gs65c3fy	333	18	to	to	TO
cord-312955-gs65c3fy	333	19	be	be	VB
cord-312955-gs65c3fy	333	20	urgently	urgently	RB
cord-312955-gs65c3fy	333	21	determined	determine	VBN
cord-312955-gs65c3fy	333	22	,	,	,
cord-312955-gs65c3fy	333	23	as	as	IN
cord-312955-gs65c3fy	333	24	to	to	TO
cord-312955-gs65c3fy	333	25	provide	provide	VB
cord-312955-gs65c3fy	333	26	a	a	DT
cord-312955-gs65c3fy	333	27	guide	guide	NN
cord-312955-gs65c3fy	333	28	for	for	IN
cord-312955-gs65c3fy	333	29	future	future	JJ
cord-312955-gs65c3fy	333	30	application	application	NN
cord-312955-gs65c3fy	333	31	of	of	IN
cord-312955-gs65c3fy	333	32	IFN	IFN	NNP
cord-312955-gs65c3fy	333	33	-	-	HYPH
cord-312955-gs65c3fy	333	34	I	I	NNP
cord-312955-gs65c3fy	333	35	therapy	therapy	NN
cord-312955-gs65c3fy	333	36	in	in	IN
cord-312955-gs65c3fy	333	37	SARS	SARS	NNP
cord-312955-gs65c3fy	333	38	-	-	HYPH
cord-312955-gs65c3fy	333	39	COV-2	COV-2	NNP
cord-312955-gs65c3fy	333	40	treatment	treatment	NN
cord-312955-gs65c3fy	333	41	.	.	.
cord-312955-gs65c3fy	334	1	The	the	DT
cord-312955-gs65c3fy	334	2	author	author	NN
cord-312955-gs65c3fy	334	3	confirms	confirm	VBZ
cord-312955-gs65c3fy	334	4	being	be	VBG
cord-312955-gs65c3fy	334	5	the	the	DT
cord-312955-gs65c3fy	334	6	sole	sole	JJ
cord-312955-gs65c3fy	334	7	contributor	contributor	NN
cord-312955-gs65c3fy	334	8	of	of	IN
cord-312955-gs65c3fy	334	9	this	this	DT
cord-312955-gs65c3fy	334	10	work	work	NN
cord-312955-gs65c3fy	334	11	and	and	CC
cord-312955-gs65c3fy	334	12	has	have	VBZ
cord-312955-gs65c3fy	334	13	approved	approve	VBN
cord-312955-gs65c3fy	334	14	it	-PRON-	PRP
cord-312955-gs65c3fy	334	15	for	for	IN
cord-312955-gs65c3fy	334	16	publication	publication	NN
cord-312955-gs65c3fy	334	17	.	.	.
cord-312955-gs65c3fy	334	18	 	 	_SP
cord-312955-gs65c3fy	335	1	Structural	structural	JJ
cord-312955-gs65c3fy	335	2	Linkage	linkage	NN
cord-312955-gs65c3fy	335	3	between	between	IN
cord-312955-gs65c3fy	335	4	Ligand	Ligand	NNP
cord-312955-gs65c3fy	335	5	Discrimination	Discrimination	NNP
cord-312955-gs65c3fy	335	6	and	and	CC
cord-312955-gs65c3fy	335	7	Receptor	Receptor	NNP
cord-312955-gs65c3fy	335	8	Activation	Activation	NNP
cord-312955-gs65c3fy	335	9	by	by	IN
cord-312955-gs65c3fy	335	10	Type	type	NN
cord-312955-gs65c3fy	335	11	I	-PRON-	PRP
cord-312955-gs65c3fy	335	12	Interferons	Interferons	NNPS
cord-312955-gs65c3fy	335	13	Structural	structural	JJ
cord-312955-gs65c3fy	335	14	and	and	CC
cord-312955-gs65c3fy	335	15	dynamic	dynamic	JJ
cord-312955-gs65c3fy	335	16	determinants	determinant	NNS
cord-312955-gs65c3fy	335	17	of	of	IN
cord-312955-gs65c3fy	335	18	type	type	NN
cord-312955-gs65c3fy	336	1	I	-PRON-	PRP
cord-312955-gs65c3fy	336	2	interferon	interferon	VBD
cord-312955-gs65c3fy	336	3	receptor	receptor	NN
cord-312955-gs65c3fy	336	4	assembly	assembly	NN
cord-312955-gs65c3fy	336	5	and	and	CC
cord-312955-gs65c3fy	336	6	their	-PRON-	PRP$
cord-312955-gs65c3fy	336	7	functional	functional	JJ
cord-312955-gs65c3fy	336	8	interpretation	interpretation	NN
cord-312955-gs65c3fy	336	9	Affinity	Affinity	NNP
cord-312955-gs65c3fy	336	10	of	of	IN
cord-312955-gs65c3fy	336	11	Stat2	stat2	NN
cord-312955-gs65c3fy	337	1	for	for	IN
cord-312955-gs65c3fy	337	2	the	the	DT
cord-312955-gs65c3fy	337	3	subunits	subunit	NNS
cord-312955-gs65c3fy	337	4	of	of	IN
cord-312955-gs65c3fy	337	5	the	the	DT
cord-312955-gs65c3fy	337	6	interferon	interferon	NNP
cord-312955-gs65c3fy	337	7	alpha	alpha	NN
cord-312955-gs65c3fy	337	8	receptor	receptor	NNP
cord-312955-gs65c3fy	337	9	STAT3	STAT3	NNP
cord-312955-gs65c3fy	337	10	activation	activation	NN
cord-312955-gs65c3fy	337	11	by	by	IN
cord-312955-gs65c3fy	337	12	type	type	NN
cord-312955-gs65c3fy	337	13	I	-PRON-	PRP
cord-312955-gs65c3fy	337	14	interferons	interferon	NNS
cord-312955-gs65c3fy	337	15	is	be	VBZ
cord-312955-gs65c3fy	337	16	dependent	dependent	JJ
cord-312955-gs65c3fy	337	17	on	on	IN
cord-312955-gs65c3fy	337	18	specific	specific	JJ
cord-312955-gs65c3fy	337	19	tyrosines	tyrosine	NNS
cord-312955-gs65c3fy	337	20	located	locate	VBN
cord-312955-gs65c3fy	337	21	in	in	IN
cord-312955-gs65c3fy	337	22	the	the	DT
cord-312955-gs65c3fy	337	23	cytoplasmic	cytoplasmic	JJ
cord-312955-gs65c3fy	337	24	domain	domain	NN
cord-312955-gs65c3fy	337	25	of	of	IN
cord-312955-gs65c3fy	337	26	interferon	interferon	NN
cord-312955-gs65c3fy	337	27	receptor	receptor	NN
cord-312955-gs65c3fy	337	28	chain	chain	NN
cord-312955-gs65c3fy	337	29	2c	2c	NNP
cord-312955-gs65c3fy	337	30	.	.	.
cord-312955-gs65c3fy	338	1	Activation	activation	NN
cord-312955-gs65c3fy	338	2	of	of	IN
cord-312955-gs65c3fy	338	3	multiple	multiple	JJ
cord-312955-gs65c3fy	338	4	STATS	stat	NNS
cord-312955-gs65c3fy	338	5	proceeds	proceed	VBZ
cord-312955-gs65c3fy	338	6	through	through	IN
cord-312955-gs65c3fy	338	7	the	the	DT
cord-312955-gs65c3fy	338	8	redundant	redundant	JJ
cord-312955-gs65c3fy	338	9	usage	usage	NN
cord-312955-gs65c3fy	338	10	of	of	IN
cord-312955-gs65c3fy	338	11	two	two	CD
cord-312955-gs65c3fy	338	12	tyrosine	tyrosine	NN
cord-312955-gs65c3fy	338	13	residues	residue	NNS
cord-312955-gs65c3fy	338	14	STAT2	STAT2	NNS
cord-312955-gs65c3fy	338	15	is	be	VBZ
cord-312955-gs65c3fy	338	16	an	an	DT
cord-312955-gs65c3fy	338	17	essential	essential	JJ
cord-312955-gs65c3fy	338	18	adaptor	adaptor	NN
cord-312955-gs65c3fy	338	19	in	in	IN
cord-312955-gs65c3fy	338	20	USP18-mediated	usp18-mediated	CD
cord-312955-gs65c3fy	338	21	suppression	suppression	NN
cord-312955-gs65c3fy	338	22	of	of	IN
cord-312955-gs65c3fy	338	23	type	type	NN
cord-312955-gs65c3fy	339	1	I	-PRON-	PRP
cord-312955-gs65c3fy	339	2	interferon	interferon	RB
cord-312955-gs65c3fy	339	3	signaling	signal	VBG
cord-312955-gs65c3fy	339	4	The	the	DT
cord-312955-gs65c3fy	339	5	unique	unique	JJ
cord-312955-gs65c3fy	339	6	role	role	NN
cord-312955-gs65c3fy	339	7	of	of	IN
cord-312955-gs65c3fy	339	8	STAT2	STAT2	NNS
cord-312955-gs65c3fy	339	9	in	in	IN
cord-312955-gs65c3fy	339	10	constitutive	constitutive	JJ
cord-312955-gs65c3fy	339	11	and	and	CC
cord-312955-gs65c3fy	339	12	IFN	IFN	NNP
cord-312955-gs65c3fy	339	13	-	-	HYPH
cord-312955-gs65c3fy	339	14	induced	induce	VBN
cord-312955-gs65c3fy	339	15	transcription	transcription	NN
cord-312955-gs65c3fy	339	16	and	and	CC
cord-312955-gs65c3fy	339	17	antiviral	antiviral	JJ
cord-312955-gs65c3fy	339	18	responses	response	NNS
cord-312955-gs65c3fy	340	1	The	the	DT
cord-312955-gs65c3fy	340	2	JAK	JAK	NNP
cord-312955-gs65c3fy	340	3	-	-	HYPH
cord-312955-gs65c3fy	340	4	STAT	STAT	NNP
cord-312955-gs65c3fy	340	5	Pathway	Pathway	NNP
cord-312955-gs65c3fy	340	6	at	at	IN
cord-312955-gs65c3fy	340	7	Twenty	Twenty	NNP
cord-312955-gs65c3fy	340	8	Phosphorylated	Phosphorylated	NNP
cord-312955-gs65c3fy	340	9	interferon	interferon	NN
cord-312955-gs65c3fy	340	10	-	-	HYPH
cord-312955-gs65c3fy	340	11	alpha	alpha	NN
cord-312955-gs65c3fy	340	12	receptor	receptor	NN
cord-312955-gs65c3fy	340	13	1	1	CD
cord-312955-gs65c3fy	340	14	subunit	subunit	NN
cord-312955-gs65c3fy	340	15	(	(	-LRB-
cord-312955-gs65c3fy	340	16	IFNaR1	IFNaR1	NNP
cord-312955-gs65c3fy	340	17	)	)	-RRB-
cord-312955-gs65c3fy	340	18	acts	act	VBZ
cord-312955-gs65c3fy	340	19	as	as	IN
cord-312955-gs65c3fy	340	20	a	a	DT
cord-312955-gs65c3fy	340	21	docking	docking	NN
cord-312955-gs65c3fy	340	22	site	site	NN
cord-312955-gs65c3fy	340	23	for	for	IN
cord-312955-gs65c3fy	340	24	the	the	DT
cord-312955-gs65c3fy	340	25	latent	latent	JJ
cord-312955-gs65c3fy	340	26	form	form	NN
cord-312955-gs65c3fy	340	27	of	of	IN
cord-312955-gs65c3fy	340	28	the	the	DT
cord-312955-gs65c3fy	340	29	113	113	CD
cord-312955-gs65c3fy	340	30	kDa	kDa	NNP
cord-312955-gs65c3fy	340	31	STAT2	STAT2	NNS
cord-312955-gs65c3fy	340	32	protein	protein	NN
cord-312955-gs65c3fy	340	33	Functional	functional	JJ
cord-312955-gs65c3fy	340	34	subdomains	subdomain	NNS
cord-312955-gs65c3fy	340	35	of	of	IN
cord-312955-gs65c3fy	340	36	STAT2	STAT2	NNS
cord-312955-gs65c3fy	340	37	required	require	VBN
cord-312955-gs65c3fy	340	38	for	for	IN
cord-312955-gs65c3fy	340	39	preassociation	preassociation	NN
cord-312955-gs65c3fy	340	40	with	with	IN
cord-312955-gs65c3fy	340	41	the	the	DT
cord-312955-gs65c3fy	340	42	alpha	alpha	NN
cord-312955-gs65c3fy	340	43	interferon	interferon	NN
cord-312955-gs65c3fy	340	44	receptor	receptor	NN
cord-312955-gs65c3fy	340	45	and	and	CC
cord-312955-gs65c3fy	340	46	for	for	IN
cord-312955-gs65c3fy	340	47	signaling	signal	VBG
cord-312955-gs65c3fy	340	48	CRISPR	CRISPR	NNP
cord-312955-gs65c3fy	340	49	/	/	SYM
cord-312955-gs65c3fy	340	50	Cas9-based	Cas9-based	NNP
cord-312955-gs65c3fy	340	51	Knockout	Knockout	NNP
cord-312955-gs65c3fy	340	52	Strategy	Strategy	NNP
cord-312955-gs65c3fy	340	53	Elucidates	elucidate	VBZ
cord-312955-gs65c3fy	340	54	Components	Components	NNP
cord-312955-gs65c3fy	340	55	Essential	Essential	NNP
cord-312955-gs65c3fy	340	56	for	for	IN
cord-312955-gs65c3fy	340	57	Type	type	NN
cord-312955-gs65c3fy	340	58	1	1	CD
cord-312955-gs65c3fy	341	1	Interferon	Interferon	NNP
cord-312955-gs65c3fy	341	2	Signaling	signal	VBG
cord-312955-gs65c3fy	341	3	in	in	IN
cord-312955-gs65c3fy	341	4	Human	Human	NNP
cord-312955-gs65c3fy	341	5	HeLa	HeLa	NNP
cord-312955-gs65c3fy	341	6	Cells	Cells	NNPS
cord-312955-gs65c3fy	341	7	STAT2	STAT2	NNS
cord-312955-gs65c3fy	341	8	/	/	SYM
cord-312955-gs65c3fy	341	9	IRF9	IRF9	NNP
cord-312955-gs65c3fy	341	10	directs	direct	VBZ
cord-312955-gs65c3fy	341	11	a	a	DT
cord-312955-gs65c3fy	341	12	prolonged	prolonged	JJ
cord-312955-gs65c3fy	341	13	ISGF3-like	ISGF3-like	NNP
cord-312955-gs65c3fy	341	14	transcriptional	transcriptional	JJ
cord-312955-gs65c3fy	341	15	response	response	NN
cord-312955-gs65c3fy	341	16	and	and	CC
cord-312955-gs65c3fy	341	17	antiviral	antiviral	JJ
cord-312955-gs65c3fy	341	18	activity	activity	NN
cord-312955-gs65c3fy	341	19	in	in	IN
cord-312955-gs65c3fy	341	20	the	the	DT
cord-312955-gs65c3fy	341	21	absence	absence	NN
cord-312955-gs65c3fy	341	22	of	of	IN
cord-312955-gs65c3fy	341	23	STAT1	stat1	NN
cord-312955-gs65c3fy	341	24	STATphosphorylation	statphosphorylation	NN
cord-312955-gs65c3fy	341	25	-	-	HYPH
cord-312955-gs65c3fy	341	26	independent	independent	JJ
cord-312955-gs65c3fy	341	27	induction	induction	NN
cord-312955-gs65c3fy	341	28	of	of	IN
cord-312955-gs65c3fy	341	29	interferon	interferon	NN
cord-312955-gs65c3fy	341	30	regulatory	regulatory	JJ
cord-312955-gs65c3fy	341	31	factor-9	factor-9	NNP
cord-312955-gs65c3fy	341	32	by	by	IN
cord-312955-gs65c3fy	341	33	interferon	interferon	NN
cord-312955-gs65c3fy	341	34	-	-	HYPH
cord-312955-gs65c3fy	341	35	beta	beta	NN
cord-312955-gs65c3fy	342	1	The	the	DT
cord-312955-gs65c3fy	342	2	yin	yin	NNP
cord-312955-gs65c3fy	342	3	and	and	CC
cord-312955-gs65c3fy	342	4	yang	yang	NNP
cord-312955-gs65c3fy	342	5	of	of	IN
cord-312955-gs65c3fy	342	6	type	type	NNP
cord-312955-gs65c3fy	343	1	I	-PRON-	PRP
cord-312955-gs65c3fy	343	2	interferon	interferon	VBD
cord-312955-gs65c3fy	343	3	activity	activity	NN
cord-312955-gs65c3fy	343	4	in	in	IN
cord-312955-gs65c3fy	343	5	bacterial	bacterial	JJ
cord-312955-gs65c3fy	343	6	infection	infection	NN
cord-312955-gs65c3fy	343	7	INTERFEROME	interferome	NN
cord-312955-gs65c3fy	343	8	:	:	:
cord-312955-gs65c3fy	344	1	the	the	DT
cord-312955-gs65c3fy	344	2	database	database	NN
cord-312955-gs65c3fy	344	3	of	of	IN
cord-312955-gs65c3fy	344	4	interferon	interferon	NN
cord-312955-gs65c3fy	344	5	regulated	regulate	VBN
cord-312955-gs65c3fy	344	6	genes	gene	NNS
cord-312955-gs65c3fy	344	7	Defining	define	VBG
cord-312955-gs65c3fy	344	8	the	the	DT
cord-312955-gs65c3fy	344	9	distinct	distinct	JJ
cord-312955-gs65c3fy	344	10	,	,	,
cord-312955-gs65c3fy	344	11	intrinsic	intrinsic	JJ
cord-312955-gs65c3fy	344	12	properties	property	NNS
cord-312955-gs65c3fy	344	13	of	of	IN
cord-312955-gs65c3fy	344	14	the	the	DT
cord-312955-gs65c3fy	344	15	novel	novel	JJ
cord-312955-gs65c3fy	344	16	type	type	NN
cord-312955-gs65c3fy	345	1	I	-PRON-	PRP
cord-312955-gs65c3fy	345	2	interferon	interferon	VBD
cord-312955-gs65c3fy	345	3	,	,	,
cord-312955-gs65c3fy	345	4	IFNϵ	IFNϵ	NNS
cord-312955-gs65c3fy	345	5	Interferon	Interferon	NNP
cord-312955-gs65c3fy	345	6	b-1a	b-1a	NN
cord-312955-gs65c3fy	345	7	for	for	IN
cord-312955-gs65c3fy	345	8	the	the	DT
cord-312955-gs65c3fy	345	9	treatment	treatment	NN
cord-312955-gs65c3fy	345	10	of	of	IN
cord-312955-gs65c3fy	345	11	Ebola	Ebola	NNP
cord-312955-gs65c3fy	345	12	virus	virus	NN
cord-312955-gs65c3fy	345	13	disease	disease	NN
cord-312955-gs65c3fy	345	14	:	:	:
cord-312955-gs65c3fy	346	1	A	a	DT
cord-312955-gs65c3fy	346	2	historically	historically	RB
cord-312955-gs65c3fy	346	3	controlled	control	VBN
cord-312955-gs65c3fy	346	4	,	,	,
cord-312955-gs65c3fy	346	5	single	single	JJ
cord-312955-gs65c3fy	346	6	-	-	HYPH
cord-312955-gs65c3fy	346	7	arm	arm	NN
cord-312955-gs65c3fy	346	8	proof	proof	NN
cord-312955-gs65c3fy	346	9	-	-	HYPH
cord-312955-gs65c3fy	346	10	of	of	IN
cord-312955-gs65c3fy	346	11	-	-	HYPH
cord-312955-gs65c3fy	346	12	concept	concept	NN
cord-312955-gs65c3fy	346	13	trial	trial	NN
cord-312955-gs65c3fy	346	14	Interferon	Interferon	NNP
cord-312955-gs65c3fy	346	15	:	:	:
cord-312955-gs65c3fy	346	16	Current	current	JJ
cord-312955-gs65c3fy	346	17	Status	Status	NNP
cord-312955-gs65c3fy	346	18	and	and	CC
cord-312955-gs65c3fy	346	19	Future	Future	NNP
cord-312955-gs65c3fy	346	20	Prospects	Prospects	NNPS
cord-312955-gs65c3fy	346	21	in	in	IN
cord-312955-gs65c3fy	346	22	Cancer	Cancer	NNP
cord-312955-gs65c3fy	346	23	Therapy	Therapy	NNP
cord-312955-gs65c3fy	346	24	Regulation	Regulation	NNP
cord-312955-gs65c3fy	346	25	of	of	IN
cord-312955-gs65c3fy	346	26	type	type	NN
cord-312955-gs65c3fy	347	1	I	-PRON-	PRP
cord-312955-gs65c3fy	347	2	interferon	interferon	RB
cord-312955-gs65c3fy	347	3	signaling	signal	VBG
cord-312955-gs65c3fy	347	4	in	in	IN
cord-312955-gs65c3fy	347	5	immunity	immunity	NN
cord-312955-gs65c3fy	347	6	and	and	CC
cord-312955-gs65c3fy	347	7	inflammation	inflammation	NN
cord-312955-gs65c3fy	347	8	:	:	:
cord-312955-gs65c3fy	348	1	A	a	DT
cord-312955-gs65c3fy	348	2	comprehensive	comprehensive	JJ
cord-312955-gs65c3fy	348	3	review	review	NN
cord-312955-gs65c3fy	348	4	Interferons	interferon	NNS
cord-312955-gs65c3fy	348	5	and	and	CC
cord-312955-gs65c3fy	348	6	viruses	virus	NNS
cord-312955-gs65c3fy	348	7	:	:	:
cord-312955-gs65c3fy	348	8	an	an	DT
cord-312955-gs65c3fy	348	9	interplay	interplay	NN
cord-312955-gs65c3fy	348	10	between	between	IN
cord-312955-gs65c3fy	348	11	induction	induction	NN
cord-312955-gs65c3fy	348	12	,	,	,
cord-312955-gs65c3fy	348	13	signalling	signal	VBG
cord-312955-gs65c3fy	348	14	,	,	,
cord-312955-gs65c3fy	348	15	antiviral	antiviral	JJ
cord-312955-gs65c3fy	348	16	responses	response	NNS
cord-312955-gs65c3fy	348	17	and	and	CC
cord-312955-gs65c3fy	348	18	virus	virus	NN
cord-312955-gs65c3fy	348	19	countermeasures	countermeasure	NNS
cord-312955-gs65c3fy	348	20	Redefining	redefine	VBG
cord-312955-gs65c3fy	348	21	the	the	DT
cord-312955-gs65c3fy	348	22	role	role	NN
cord-312955-gs65c3fy	348	23	of	of	IN
cord-312955-gs65c3fy	348	24	interferon	interferon	NN
cord-312955-gs65c3fy	348	25	in	in	IN
cord-312955-gs65c3fy	348	26	the	the	DT
cord-312955-gs65c3fy	348	27	treatment	treatment	NN
cord-312955-gs65c3fy	348	28	of	of	IN
cord-312955-gs65c3fy	348	29	malignant	malignant	JJ
cord-312955-gs65c3fy	348	30	diseases	disease	NNS
cord-312955-gs65c3fy	349	1	Interferon	interferon	NN
cord-312955-gs65c3fy	350	1	-beta-1b	-beta-1b	NNP
cord-312955-gs65c3fy	350	2	-	-	HYPH
cord-312955-gs65c3fy	350	3	induced	induce	VBN
cord-312955-gs65c3fy	350	4	short	short	JJ
cord-312955-gs65c3fy	350	5	-	-	HYPH
cord-312955-gs65c3fy	350	6	and	and	CC
cord-312955-gs65c3fy	350	7	long	long	JJ
cord-312955-gs65c3fy	350	8	-	-	HYPH
cord-312955-gs65c3fy	350	9	term	term	NN
cord-312955-gs65c3fy	350	10	signatures	signature	NNS
cord-312955-gs65c3fy	350	11	of	of	IN
cord-312955-gs65c3fy	350	12	treatment	treatment	NN
cord-312955-gs65c3fy	350	13	activity	activity	NN
cord-312955-gs65c3fy	350	14	in	in	IN
cord-312955-gs65c3fy	350	15	multiple	multiple	JJ
cord-312955-gs65c3fy	350	16	sclerosis	sclerosis	NN
cord-312955-gs65c3fy	350	17	Inverse	inverse	NN
cord-312955-gs65c3fy	350	18	interference	interference	NN
cord-312955-gs65c3fy	350	19	:	:	:
cord-312955-gs65c3fy	351	1	how	how	WRB
cord-312955-gs65c3fy	351	2	viruses	virus	NNS
cord-312955-gs65c3fy	351	3	fight	fight	VBP
cord-312955-gs65c3fy	351	4	the	the	DT
cord-312955-gs65c3fy	351	5	interferon	interferon	NN
cord-312955-gs65c3fy	351	6	system	system	NN
cord-312955-gs65c3fy	351	7	Type	type	NN
cord-312955-gs65c3fy	351	8	-	-	:
cord-312955-gs65c3fy	351	9	I	i	NN
cord-312955-gs65c3fy	352	1	Interferon	interferon	NN
cord-312955-gs65c3fy	352	2	Responses	response	NNS
cord-312955-gs65c3fy	352	3	:	:	:
cord-312955-gs65c3fy	353	1	From	from	IN
cord-312955-gs65c3fy	353	2	Friend	friend	NN
cord-312955-gs65c3fy	353	3	to	to	IN
cord-312955-gs65c3fy	353	4	Foe	Foe	NNP
cord-312955-gs65c3fy	353	5	in	in	IN
cord-312955-gs65c3fy	353	6	the	the	DT
cord-312955-gs65c3fy	353	7	Battle	Battle	NNP
cord-312955-gs65c3fy	353	8	against	against	IN
cord-312955-gs65c3fy	353	9	Chronic	Chronic	NNP
cord-312955-gs65c3fy	353	10	Viral	Viral	NNP
cord-312955-gs65c3fy	353	11	Infection	Infection	NNP
cord-312955-gs65c3fy	353	12	Mechanisms	Mechanisms	NNPS
cord-312955-gs65c3fy	353	13	underlying	underlie	VBG
cord-312955-gs65c3fy	353	14	the	the	DT
cord-312955-gs65c3fy	353	15	inhibition	inhibition	NN
cord-312955-gs65c3fy	353	16	of	of	IN
cord-312955-gs65c3fy	353	17	interferon	interferon	NN
cord-312955-gs65c3fy	353	18	signaling	signal	VBG
cord-312955-gs65c3fy	353	19	by	by	IN
cord-312955-gs65c3fy	353	20	viruses	virus	NNS
cord-312955-gs65c3fy	354	1	Ebola	Ebola	NNP
cord-312955-gs65c3fy	354	2	Virus	virus	NN
cord-312955-gs65c3fy	354	3	VP24	VP24	NNP
cord-312955-gs65c3fy	354	4	Targets	target	VBZ
cord-312955-gs65c3fy	354	5	a	a	DT
cord-312955-gs65c3fy	354	6	Unique	unique	JJ
cord-312955-gs65c3fy	354	7	NLS	nls	NN
cord-312955-gs65c3fy	354	8	Binding	Binding	NNP
cord-312955-gs65c3fy	354	9	Site	site	NN
cord-312955-gs65c3fy	354	10	on	on	IN
cord-312955-gs65c3fy	354	11	Karyopherin	Karyopherin	NNP
cord-312955-gs65c3fy	354	12	Alpha	Alpha	NNP
cord-312955-gs65c3fy	354	13	5	5	CD
cord-312955-gs65c3fy	355	1	to	to	TO
cord-312955-gs65c3fy	355	2	Selectively	selectively	RB
cord-312955-gs65c3fy	355	3	Compete	compete	VB
cord-312955-gs65c3fy	355	4	with	with	IN
cord-312955-gs65c3fy	355	5	Nuclear	Nuclear	NNP
cord-312955-gs65c3fy	355	6	Import	Import	NNP
cord-312955-gs65c3fy	355	7	of	of	IN
cord-312955-gs65c3fy	355	8	Phosphorylated	Phosphorylated	NNP
cord-312955-gs65c3fy	355	9	STAT1	STAT1	NNP
cord-312955-gs65c3fy	355	10	Ebolaviruses	Ebolaviruses	NNP
cord-312955-gs65c3fy	355	11	:	:	:
cord-312955-gs65c3fy	356	1	New	new	JJ
cord-312955-gs65c3fy	356	2	roles	role	NNS
cord-312955-gs65c3fy	356	3	for	for	IN
cord-312955-gs65c3fy	356	4	old	old	JJ
cord-312955-gs65c3fy	356	5	proteins	protein	NNS
cord-312955-gs65c3fy	356	6	COVID-19	covid-19	VBP
cord-312955-gs65c3fy	356	7	infection	infection	NN
cord-312955-gs65c3fy	356	8	:	:	:
cord-312955-gs65c3fy	356	9	Origin	origin	NN
cord-312955-gs65c3fy	356	10	,	,	,
cord-312955-gs65c3fy	356	11	transmission	transmission	NN
cord-312955-gs65c3fy	356	12	,	,	,
cord-312955-gs65c3fy	356	13	and	and	CC
cord-312955-gs65c3fy	356	14	characteristics	characteristic	NNS
cord-312955-gs65c3fy	356	15	of	of	IN
cord-312955-gs65c3fy	356	16	human	human	JJ
cord-312955-gs65c3fy	356	17	coronaviruses	coronaviruse	NNS
cord-312955-gs65c3fy	357	1	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	357	2	Outbreak	Outbreak	NNP
cord-312955-gs65c3fy	357	3	:	:	:
cord-312955-gs65c3fy	358	1	An	an	DT
cord-312955-gs65c3fy	358	2	Overview	Overview	NNP
cord-312955-gs65c3fy	358	3	Evolutionary	evolutionary	JJ
cord-312955-gs65c3fy	358	4	origins	origin	NNS
cord-312955-gs65c3fy	358	5	of	of	IN
cord-312955-gs65c3fy	358	6	the	the	DT
cord-312955-gs65c3fy	358	7	SARS	SARS	NNP
cord-312955-gs65c3fy	358	8	-	-	HYPH
cord-312955-gs65c3fy	358	9	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	358	10	sarbecovirus	sarbecovirus	JJ
cord-312955-gs65c3fy	358	11	lineage	lineage	NN
cord-312955-gs65c3fy	358	12	responsible	responsible	JJ
cord-312955-gs65c3fy	358	13	for	for	IN
cord-312955-gs65c3fy	358	14	the	the	DT
cord-312955-gs65c3fy	358	15	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	358	16	pandemic	pandemic	NN
cord-312955-gs65c3fy	359	1	The	the	DT
cord-312955-gs65c3fy	359	2	Proteins	protein	NNS
cord-312955-gs65c3fy	359	3	of	of	IN
cord-312955-gs65c3fy	359	4	Severe	severe	JJ
cord-312955-gs65c3fy	359	5	Acute	acute	JJ
cord-312955-gs65c3fy	359	6	Respiratory	respiratory	JJ
cord-312955-gs65c3fy	359	7	Syndrome	syndrome	NN
cord-312955-gs65c3fy	360	1	Coronavirus-2	Coronavirus-2	NNP
cord-312955-gs65c3fy	361	1	(	(	-LRB-
cord-312955-gs65c3fy	361	2	SARS	SARS	NNP
cord-312955-gs65c3fy	361	3	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	361	4	or	or	CC
cord-312955-gs65c3fy	361	5	n	n	NNP
cord-312955-gs65c3fy	361	6	-	-	HYPH
cord-312955-gs65c3fy	361	7	COV19	COV19	NNP
cord-312955-gs65c3fy	361	8	)	)	-RRB-
cord-312955-gs65c3fy	361	9	,	,	.
cord-312955-gs65c3fy	362	1	the	the	DT
cord-312955-gs65c3fy	362	2	Cause	Cause	NNP
cord-312955-gs65c3fy	362	3	of	of	IN
cord-312955-gs65c3fy	362	4	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	362	5	Type	Type	NNP
cord-312955-gs65c3fy	362	6	I	I	NNP
cord-312955-gs65c3fy	362	7	and	and	CC
cord-312955-gs65c3fy	362	8	Type	Type	NNP
cord-312955-gs65c3fy	362	9	III	III	NNP
cord-312955-gs65c3fy	362	10	Interferons	Interferons	NNPS
cord-312955-gs65c3fy	362	11	-Induction	-induction	XX
cord-312955-gs65c3fy	362	12	,	,	,
cord-312955-gs65c3fy	362	13	Signaling	signaling	NN
cord-312955-gs65c3fy	362	14	,	,	,
cord-312955-gs65c3fy	362	15	Evasion	Evasion	NNP
cord-312955-gs65c3fy	362	16	,	,	,
cord-312955-gs65c3fy	362	17	and	and	CC
cord-312955-gs65c3fy	362	18	Application	Application	NNP
cord-312955-gs65c3fy	362	19	to	to	IN
cord-312955-gs65c3fy	362	20	Combat	combat	NN
cord-312955-gs65c3fy	363	1	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	363	2	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	363	3	:	:	:
cord-312955-gs65c3fy	363	4	Pathogenesis	Pathogenesis	NNP
cord-312955-gs65c3fy	363	5	,	,	,
cord-312955-gs65c3fy	363	6	cytokine	cytokine	JJ
cord-312955-gs65c3fy	363	7	storm	storm	NN
cord-312955-gs65c3fy	363	8	and	and	CC
cord-312955-gs65c3fy	363	9	therapeutic	therapeutic	JJ
cord-312955-gs65c3fy	363	10	potential	potential	NN
cord-312955-gs65c3fy	363	11	of	of	IN
cord-312955-gs65c3fy	363	12	interferons	interferon	NNS
cord-312955-gs65c3fy	363	13	Structural	structural	JJ
cord-312955-gs65c3fy	363	14	basis	basis	NN
cord-312955-gs65c3fy	363	15	of	of	IN
cord-312955-gs65c3fy	363	16	a	a	DT
cord-312955-gs65c3fy	363	17	unique	unique	JJ
cord-312955-gs65c3fy	363	18	interferon	interferon	NN
cord-312955-gs65c3fy	363	19	-	-	HYPH
cord-312955-gs65c3fy	363	20	beta	beta	NN
cord-312955-gs65c3fy	363	21	signaling	signal	VBG
cord-312955-gs65c3fy	363	22	axis	axis	NN
cord-312955-gs65c3fy	363	23	mediated	mediate	VBN
cord-312955-gs65c3fy	363	24	via	via	IN
cord-312955-gs65c3fy	363	25	the	the	DT
cord-312955-gs65c3fy	363	26	receptor	receptor	NN
cord-312955-gs65c3fy	364	1	IFNAR1	IFNAR1	NNP
cord-312955-gs65c3fy	365	1	The	the	DT
cord-312955-gs65c3fy	365	2	molecular	molecular	JJ
cord-312955-gs65c3fy	365	3	basis	basis	NN
cord-312955-gs65c3fy	365	4	for	for	IN
cord-312955-gs65c3fy	365	5	differential	differential	JJ
cord-312955-gs65c3fy	365	6	type	type	NN
cord-312955-gs65c3fy	365	7	I	-PRON-	PRP
cord-312955-gs65c3fy	365	8	interferon	interferon	NN
cord-312955-gs65c3fy	365	9	signaling	signal	VBG
cord-312955-gs65c3fy	365	10	Understanding	understand	VBG
cord-312955-gs65c3fy	365	11	cytokine	cytokine	NN
cord-312955-gs65c3fy	365	12	and	and	CC
cord-312955-gs65c3fy	365	13	growth	growth	NN
cord-312955-gs65c3fy	365	14	factor	factor	NN
cord-312955-gs65c3fy	365	15	receptor	receptor	NN
cord-312955-gs65c3fy	365	16	activation	activation	NN
cord-312955-gs65c3fy	365	17	mechanisms	mechanism	NNS
cord-312955-gs65c3fy	365	18	Mechanism	Mechanism	NNP
cord-312955-gs65c3fy	365	19	of	of	IN
cord-312955-gs65c3fy	365	20	homodimeric	homodimeric	NNP
cord-312955-gs65c3fy	365	21	cytokine	cytokine	NN
cord-312955-gs65c3fy	365	22	receptor	receptor	NN
cord-312955-gs65c3fy	365	23	activation	activation	NN
cord-312955-gs65c3fy	365	24	and	and	CC
cord-312955-gs65c3fy	365	25	dysregulation	dysregulation	NN
cord-312955-gs65c3fy	365	26	by	by	IN
cord-312955-gs65c3fy	365	27	oncogenic	oncogenic	JJ
cord-312955-gs65c3fy	365	28	mutations	mutation	NNS
cord-312955-gs65c3fy	365	29	Type	type	NN
cord-312955-gs65c3fy	365	30	I	-PRON-	PRP
cord-312955-gs65c3fy	366	1	Interferon	interferon	NN
cord-312955-gs65c3fy	366	2	Signaling	signaling	NN
cord-312955-gs65c3fy	366	3	Is	be	VBZ
cord-312955-gs65c3fy	366	4	Decoupled	decouple	VBN
cord-312955-gs65c3fy	366	5	from	from	IN
cord-312955-gs65c3fy	366	6	Specific	Specific	NNP
cord-312955-gs65c3fy	366	7	Receptor	Receptor	NNP
cord-312955-gs65c3fy	366	8	Orientation	Orientation	NNP
cord-312955-gs65c3fy	366	9	through	through	IN
cord-312955-gs65c3fy	366	10	Lenient	lenient	JJ
cord-312955-gs65c3fy	366	11	Requirements	requirement	NNS
cord-312955-gs65c3fy	366	12	of	of	IN
cord-312955-gs65c3fy	366	13	the	the	DT
cord-312955-gs65c3fy	366	14	Transmembrane	Transmembrane	NNP
cord-312955-gs65c3fy	366	15	Domain	Domain	NNP
cord-312955-gs65c3fy	366	16	Receptor	Receptor	NNP
cord-312955-gs65c3fy	366	17	dimerization	dimerization	NN
cord-312955-gs65c3fy	366	18	dynamics	dynamic	NNS
cord-312955-gs65c3fy	366	19	as	as	IN
cord-312955-gs65c3fy	366	20	a	a	DT
cord-312955-gs65c3fy	366	21	regulatory	regulatory	JJ
cord-312955-gs65c3fy	366	22	valve	valve	NN
cord-312955-gs65c3fy	366	23	for	for	IN
cord-312955-gs65c3fy	366	24	plasticity	plasticity	NN
cord-312955-gs65c3fy	366	25	of	of	IN
cord-312955-gs65c3fy	366	26	type	type	NN
cord-312955-gs65c3fy	367	1	I	-PRON-	PRP
cord-312955-gs65c3fy	367	2	interferon	interferon	RB
cord-312955-gs65c3fy	367	3	signaling	signal	VBG
cord-312955-gs65c3fy	367	4	Binding	binding	NN
cord-312955-gs65c3fy	367	5	and	and	CC
cord-312955-gs65c3fy	367	6	activity	activity	NN
cord-312955-gs65c3fy	367	7	of	of	IN
cord-312955-gs65c3fy	367	8	all	all	DT
cord-312955-gs65c3fy	367	9	human	human	JJ
cord-312955-gs65c3fy	367	10	alpha	alpha	NN
cord-312955-gs65c3fy	368	1	interferon	interferon	NNP
cord-312955-gs65c3fy	368	2	subtypes	subtype	NNS
cord-312955-gs65c3fy	369	1	Inquiring	inquire	VBG
cord-312955-gs65c3fy	369	2	into	into	IN
cord-312955-gs65c3fy	369	3	the	the	DT
cord-312955-gs65c3fy	369	4	differential	differential	JJ
cord-312955-gs65c3fy	369	5	action	action	NN
cord-312955-gs65c3fy	369	6	of	of	IN
cord-312955-gs65c3fy	369	7	interferons	interferon	NNS
cord-312955-gs65c3fy	369	8	(	(	-LRB-
cord-312955-gs65c3fy	369	9	IFNs	ifn	NNS
cord-312955-gs65c3fy	369	10	)	)	-RRB-
cord-312955-gs65c3fy	370	1	:	:	:
cord-312955-gs65c3fy	370	2	an	an	DT
cord-312955-gs65c3fy	370	3	IFN	IFN	NNP
cord-312955-gs65c3fy	370	4	-	-	HYPH
cord-312955-gs65c3fy	370	5	alpha2	alpha2	NN
cord-312955-gs65c3fy	370	6	mutant	mutant	NN
cord-312955-gs65c3fy	370	7	with	with	IN
cord-312955-gs65c3fy	370	8	enhanced	enhanced	JJ
cord-312955-gs65c3fy	370	9	affinity	affinity	NN
cord-312955-gs65c3fy	370	10	to	to	IN
cord-312955-gs65c3fy	370	11	IFNAR1	ifnar1	PRP
cord-312955-gs65c3fy	370	12	is	be	VBZ
cord-312955-gs65c3fy	370	13	functionally	functionally	RB
cord-312955-gs65c3fy	370	14	similar	similar	JJ
cord-312955-gs65c3fy	370	15	to	to	IN
cord-312955-gs65c3fy	370	16	IFN	IFN	NNP
cord-312955-gs65c3fy	370	17	-	-	HYPH
cord-312955-gs65c3fy	370	18	beta	beta	NNP
cord-312955-gs65c3fy	370	19	Properties	Properties	NNPS
cord-312955-gs65c3fy	370	20	and	and	CC
cord-312955-gs65c3fy	370	21	functions	function	NNS
cord-312955-gs65c3fy	370	22	of	of	IN
cord-312955-gs65c3fy	370	23	the	the	DT
cord-312955-gs65c3fy	370	24	novel	novel	JJ
cord-312955-gs65c3fy	370	25	type	type	NN
cord-312955-gs65c3fy	371	1	i	i	PRP
cord-312955-gs65c3fy	371	2	interferon	interferon	VBD
cord-312955-gs65c3fy	371	3	epsilon	epsilon	NN
cord-312955-gs65c3fy	372	1	The	the	DT
cord-312955-gs65c3fy	372	2	stability	stability	NN
cord-312955-gs65c3fy	372	3	of	of	IN
cord-312955-gs65c3fy	372	4	the	the	DT
cord-312955-gs65c3fy	372	5	ternary	ternary	JJ
cord-312955-gs65c3fy	372	6	interferon	interferon	NN
cord-312955-gs65c3fy	372	7	-	-	HYPH
cord-312955-gs65c3fy	372	8	receptor	receptor	NN
cord-312955-gs65c3fy	372	9	complex	complex	NN
cord-312955-gs65c3fy	372	10	rather	rather	RB
cord-312955-gs65c3fy	372	11	than	than	IN
cord-312955-gs65c3fy	372	12	the	the	DT
cord-312955-gs65c3fy	372	13	affinity	affinity	NN
cord-312955-gs65c3fy	372	14	to	to	IN
cord-312955-gs65c3fy	372	15	the	the	DT
cord-312955-gs65c3fy	372	16	individual	individual	JJ
cord-312955-gs65c3fy	372	17	subunits	subunit	NNS
cord-312955-gs65c3fy	372	18	dictates	dictate	VBZ
cord-312955-gs65c3fy	372	19	differential	differential	JJ
cord-312955-gs65c3fy	372	20	biological	biological	JJ
cord-312955-gs65c3fy	372	21	activities	activity	NNS
cord-312955-gs65c3fy	373	1	New	new	JJ
cord-312955-gs65c3fy	373	2	structural	structural	JJ
cord-312955-gs65c3fy	373	3	and	and	CC
cord-312955-gs65c3fy	373	4	functional	functional	JJ
cord-312955-gs65c3fy	373	5	aspects	aspect	NNS
cord-312955-gs65c3fy	373	6	of	of	IN
cord-312955-gs65c3fy	373	7	the	the	DT
cord-312955-gs65c3fy	373	8	type	type	NN
cord-312955-gs65c3fy	374	1	I	-PRON-	PRP
cord-312955-gs65c3fy	374	2	interferon	interferon	NN
cord-312955-gs65c3fy	374	3	-	-	HYPH
cord-312955-gs65c3fy	374	4	receptor	receptor	NN
cord-312955-gs65c3fy	374	5	interaction	interaction	NN
cord-312955-gs65c3fy	374	6	revealed	reveal	VBN
cord-312955-gs65c3fy	374	7	by	by	IN
cord-312955-gs65c3fy	374	8	comprehensive	comprehensive	JJ
cord-312955-gs65c3fy	374	9	mutational	mutational	JJ
cord-312955-gs65c3fy	374	10	analysis	analysis	NN
cord-312955-gs65c3fy	374	11	of	of	IN
cord-312955-gs65c3fy	374	12	the	the	DT
cord-312955-gs65c3fy	374	13	binding	bind	VBG
cord-312955-gs65c3fy	374	14	interface	interface	NN
cord-312955-gs65c3fy	375	1	An	an	DT
cord-312955-gs65c3fy	375	2	Interferon	Interferon	NNP
cord-312955-gs65c3fy	375	3	{	{	-LRB-
cord-312955-gs65c3fy	375	4	alpha}2	alpha}2	JJ
cord-312955-gs65c3fy	375	5	Mutant	mutant	NN
cord-312955-gs65c3fy	375	6	Optimized	optimize	VBN
cord-312955-gs65c3fy	375	7	by	by	IN
cord-312955-gs65c3fy	375	8	Phage	Phage	NNP
cord-312955-gs65c3fy	375	9	Display	Display	NNP
cord-312955-gs65c3fy	375	10	for	for	IN
cord-312955-gs65c3fy	375	11	IFNAR1	ifnar1	NN
cord-312955-gs65c3fy	376	1	Binding	binding	NN
cord-312955-gs65c3fy	376	2	Confers	confer	VBZ
cord-312955-gs65c3fy	376	3	Specifically	specifically	RB
cord-312955-gs65c3fy	377	1	Enhanced	Enhanced	NNP
cord-312955-gs65c3fy	377	2	Antitumor	Antitumor	NNP
cord-312955-gs65c3fy	377	3	Activities	Activities	NNPS
cord-312955-gs65c3fy	377	4	Multifaceted	multifaceted	JJ
cord-312955-gs65c3fy	377	5	activities	activity	NNS
cord-312955-gs65c3fy	377	6	of	of	IN
cord-312955-gs65c3fy	377	7	type	type	NN
cord-312955-gs65c3fy	378	1	I	-PRON-	PRP
cord-312955-gs65c3fy	378	2	interferon	interferon	NN
cord-312955-gs65c3fy	378	3	are	be	VBP
cord-312955-gs65c3fy	378	4	revealed	reveal	VBN
cord-312955-gs65c3fy	378	5	by	by	IN
cord-312955-gs65c3fy	378	6	a	a	DT
cord-312955-gs65c3fy	378	7	receptor	receptor	NN
cord-312955-gs65c3fy	378	8	antagonist	antagonist	NN
cord-312955-gs65c3fy	378	9	Stochastic	Stochastic	NNP
cord-312955-gs65c3fy	378	10	Receptor	Receptor	NNP
cord-312955-gs65c3fy	378	11	Expression	Expression	NNP
cord-312955-gs65c3fy	378	12	Determines	determine	VBZ
cord-312955-gs65c3fy	378	13	Cell	Cell	NNP
cord-312955-gs65c3fy	378	14	Fate	Fate	NNP
cord-312955-gs65c3fy	378	15	upon	upon	IN
cord-312955-gs65c3fy	378	16	Interferon	Interferon	NNP
cord-312955-gs65c3fy	378	17	Treatment	Treatment	NNP
cord-312955-gs65c3fy	378	18	Regulation	Regulation	NNP
cord-312955-gs65c3fy	378	19	of	of	IN
cord-312955-gs65c3fy	378	20	type	type	NN
cord-312955-gs65c3fy	379	1	I	-PRON-	PRP
cord-312955-gs65c3fy	380	1	interferon	interferon	NNP
cord-312955-gs65c3fy	380	2	responses	response	NNS
cord-312955-gs65c3fy	381	1	USP18	USP18	NNP
cord-312955-gs65c3fy	381	2	establishes	establish	VBZ
cord-312955-gs65c3fy	381	3	the	the	DT
cord-312955-gs65c3fy	381	4	transcriptional	transcriptional	JJ
cord-312955-gs65c3fy	381	5	and	and	CC
cord-312955-gs65c3fy	381	6	anti	anti	JJ
cord-312955-gs65c3fy	381	7	-	-	JJ
cord-312955-gs65c3fy	381	8	proliferative	proliferative	JJ
cord-312955-gs65c3fy	381	9	interferon	interferon	NN
cord-312955-gs65c3fy	381	10	alpha/	alpha/	NN
cord-312955-gs65c3fy	381	11	beta	beta	NN
cord-312955-gs65c3fy	381	12	differential	differential	NN
cord-312955-gs65c3fy	381	13	Kinase	Kinase	NNP
cord-312955-gs65c3fy	381	14	inhibition	inhibition	NN
cord-312955-gs65c3fy	381	15	,	,	,
cord-312955-gs65c3fy	381	16	competitive	competitive	JJ
cord-312955-gs65c3fy	381	17	binding	binding	NN
cord-312955-gs65c3fy	381	18	and	and	CC
cord-312955-gs65c3fy	381	19	proteasomal	proteasomal	JJ
cord-312955-gs65c3fy	381	20	degradation	degradation	NN
cord-312955-gs65c3fy	381	21	:	:	:
cord-312955-gs65c3fy	381	22	resolving	resolve	VBG
cord-312955-gs65c3fy	381	23	the	the	DT
cord-312955-gs65c3fy	381	24	molecular	molecular	JJ
cord-312955-gs65c3fy	381	25	function	function	NN
cord-312955-gs65c3fy	381	26	of	of	IN
cord-312955-gs65c3fy	381	27	the	the	DT
cord-312955-gs65c3fy	381	28	suppressor	suppressor	NN
cord-312955-gs65c3fy	381	29	of	of	IN
cord-312955-gs65c3fy	381	30	cytokine	cytokine	NN
cord-312955-gs65c3fy	381	31	signaling	signaling	NN
cord-312955-gs65c3fy	381	32	(	(	-LRB-
cord-312955-gs65c3fy	381	33	SOCS	SOCS	NNP
cord-312955-gs65c3fy	381	34	)	)	-RRB-
cord-312955-gs65c3fy	381	35	proteins	protein	VBZ
cord-312955-gs65c3fy	381	36	SCF	SCF	NNP
cord-312955-gs65c3fy	381	37	(	(	-LRB-
cord-312955-gs65c3fy	381	38	HOS	HOS	NNP
cord-312955-gs65c3fy	381	39	)	)	-RRB-
cord-312955-gs65c3fy	382	1	ubiquitin	ubiquitin	NNP
cord-312955-gs65c3fy	382	2	ligase	ligase	NN
cord-312955-gs65c3fy	382	3	mediates	mediate	VBZ
cord-312955-gs65c3fy	382	4	the	the	DT
cord-312955-gs65c3fy	382	5	ligand	ligand	NN
cord-312955-gs65c3fy	382	6	-	-	HYPH
cord-312955-gs65c3fy	382	7	induced	induce	VBN
cord-312955-gs65c3fy	382	8	down	down	NN
cord-312955-gs65c3fy	382	9	-	-	HYPH
cord-312955-gs65c3fy	382	10	regulation	regulation	NN
cord-312955-gs65c3fy	382	11	of	of	IN
cord-312955-gs65c3fy	382	12	the	the	DT
cord-312955-gs65c3fy	382	13	interferon	interferon	NN
cord-312955-gs65c3fy	382	14	-	-	HYPH
cord-312955-gs65c3fy	382	15	alpha	alpha	NN
cord-312955-gs65c3fy	382	16	receptor	receptor	NN
cord-312955-gs65c3fy	382	17	Triggering	trigger	VBG
cord-312955-gs65c3fy	382	18	ubiquitination	ubiquitination	NN
cord-312955-gs65c3fy	382	19	of	of	IN
cord-312955-gs65c3fy	382	20	IFNAR1	ifnar1	NN
cord-312955-gs65c3fy	382	21	protects	protect	VBZ
cord-312955-gs65c3fy	382	22	tissues	tissue	NNS
cord-312955-gs65c3fy	382	23	from	from	IN
cord-312955-gs65c3fy	382	24	inflammatory	inflammatory	JJ
cord-312955-gs65c3fy	382	25	injury	injury	NN
cord-312955-gs65c3fy	383	1	Therapeutic	therapeutic	JJ
cord-312955-gs65c3fy	383	2	Elimination	Elimination	NNP
cord-312955-gs65c3fy	383	3	of	of	IN
cord-312955-gs65c3fy	383	4	the	the	DT
cord-312955-gs65c3fy	383	5	Type	type	NN
cord-312955-gs65c3fy	383	6	1	1	CD
cord-312955-gs65c3fy	383	7	Interferon	Interferon	NNP
cord-312955-gs65c3fy	383	8	Receptor	Receptor	NNP
cord-312955-gs65c3fy	383	9	for	for	IN
cord-312955-gs65c3fy	383	10	Treating	treat	VBG
cord-312955-gs65c3fy	383	11	Psoriatic	psoriatic	JJ
cord-312955-gs65c3fy	383	12	Skin	skin	NN
cord-312955-gs65c3fy	383	13	Inflammation	inflammation	NN
cord-312955-gs65c3fy	384	1	The	the	DT
cord-312955-gs65c3fy	384	2	microRNA	microRNA	NNP
cord-312955-gs65c3fy	384	3	miR-155	miR-155	NNP
cord-312955-gs65c3fy	384	4	controls	control	VBZ
cord-312955-gs65c3fy	384	5	CD8(+	CD8(+	NNP
cord-312955-gs65c3fy	384	6	)	)	-RRB-
cord-312955-gs65c3fy	385	1	T	T	NNP
cord-312955-gs65c3fy	385	2	cell	cell	NN
cord-312955-gs65c3fy	385	3	responses	response	NNS
cord-312955-gs65c3fy	385	4	by	by	IN
cord-312955-gs65c3fy	385	5	regulating	regulate	VBG
cord-312955-gs65c3fy	385	6	interferon	interferon	NN
cord-312955-gs65c3fy	385	7	signaling	signal	VBG
cord-312955-gs65c3fy	385	8	Interferons	Interferons	NNPS
cord-312955-gs65c3fy	385	9	in	in	IN
cord-312955-gs65c3fy	385	10	autoimmune	autoimmune	JJ
cord-312955-gs65c3fy	385	11	and	and	CC
cord-312955-gs65c3fy	385	12	inflammatory	inflammatory	JJ
cord-312955-gs65c3fy	385	13	diseases	disease	NNS
cord-312955-gs65c3fy	386	1	:	:	:
cord-312955-gs65c3fy	386	2	regulation	regulation	NN
cord-312955-gs65c3fy	386	3	and	and	CC
cord-312955-gs65c3fy	386	4	roles	role	NNS
cord-312955-gs65c3fy	386	5	Type	type	NN
cord-312955-gs65c3fy	387	1	I	-PRON-	PRP
cord-312955-gs65c3fy	387	2	interferons	interferon	NNS
cord-312955-gs65c3fy	387	3	in	in	IN
cord-312955-gs65c3fy	387	4	host	host	NN
cord-312955-gs65c3fy	387	5	defence	defence	NN
cord-312955-gs65c3fy	387	6	and	and	CC
cord-312955-gs65c3fy	387	7	inflammatory	inflammatory	JJ
cord-312955-gs65c3fy	387	8	diseases	disease	NNS
cord-312955-gs65c3fy	388	1	How	how	WRB
cord-312955-gs65c3fy	388	2	type	type	NN
cord-312955-gs65c3fy	388	3	I	-PRON-	PRP
cord-312955-gs65c3fy	388	4	interferons	interferon	NNS
cord-312955-gs65c3fy	388	5	work	work	VBP
cord-312955-gs65c3fy	388	6	in	in	IN
cord-312955-gs65c3fy	388	7	multiple	multiple	JJ
cord-312955-gs65c3fy	388	8	sclerosis	sclerosis	NN
cord-312955-gs65c3fy	388	9	and	and	CC
cord-312955-gs65c3fy	388	10	other	other	JJ
cord-312955-gs65c3fy	388	11	diseases	disease	NNS
cord-312955-gs65c3fy	388	12	:	:	:
cord-312955-gs65c3fy	388	13	some	some	DT
cord-312955-gs65c3fy	388	14	unexpected	unexpected	JJ
cord-312955-gs65c3fy	388	15	mechanisms	mechanism	NNS
cord-312955-gs65c3fy	388	16	Enhanced	enhance	VBN
cord-312955-gs65c3fy	388	17	In	in	IN
cord-312955-gs65c3fy	388	18	Vivo	Vivo	NNP
cord-312955-gs65c3fy	388	19	Efficacy	Efficacy	NNP
cord-312955-gs65c3fy	388	20	of	of	IN
cord-312955-gs65c3fy	388	21	a	a	DT
cord-312955-gs65c3fy	388	22	Type	type	NN
cord-312955-gs65c3fy	389	1	I	-PRON-	PRP
cord-312955-gs65c3fy	389	2	Interferon	Interferon	NNP
cord-312955-gs65c3fy	389	3	Superagonist	Superagonist	NNP
cord-312955-gs65c3fy	389	4	with	with	IN
cord-312955-gs65c3fy	389	5	Extended	Extended	NNP
cord-312955-gs65c3fy	389	6	Plasma	Plasma	NNP
cord-312955-gs65c3fy	389	7	Half	half	JJ
cord-312955-gs65c3fy	389	8	-	-	HYPH
cord-312955-gs65c3fy	389	9	life	life	NN
cord-312955-gs65c3fy	389	10	in	in	IN
cord-312955-gs65c3fy	389	11	a	a	DT
cord-312955-gs65c3fy	389	12	Mouse	Mouse	NNP
cord-312955-gs65c3fy	389	13	Model	Model	NNP
cord-312955-gs65c3fy	389	14	of	of	IN
cord-312955-gs65c3fy	389	15	Multiple	Multiple	NNP
cord-312955-gs65c3fy	389	16	Sclerosis	Sclerosis	NNP
cord-312955-gs65c3fy	389	17	Persistent	persistent	JJ
cord-312955-gs65c3fy	389	18	LCMV	LCMV	NNP
cord-312955-gs65c3fy	389	19	infection	infection	NN
cord-312955-gs65c3fy	389	20	is	be	VBZ
cord-312955-gs65c3fy	389	21	controlled	control	VBN
cord-312955-gs65c3fy	389	22	by	by	IN
cord-312955-gs65c3fy	389	23	blockade	blockade	NN
cord-312955-gs65c3fy	389	24	of	of	IN
cord-312955-gs65c3fy	389	25	type	type	NN
cord-312955-gs65c3fy	390	1	I	-PRON-	PRP
cord-312955-gs65c3fy	390	2	interferon	interferon	RB
cord-312955-gs65c3fy	390	3	signaling	signal	VBG
cord-312955-gs65c3fy	390	4	The	the	DT
cord-312955-gs65c3fy	390	5	Role	role	NN
cord-312955-gs65c3fy	390	6	of	of	IN
cord-312955-gs65c3fy	390	7	Interferons	Interferons	NNPS
cord-312955-gs65c3fy	390	8	in	in	IN
cord-312955-gs65c3fy	390	9	Inflammation	inflammation	NN
cord-312955-gs65c3fy	390	10	and	and	CC
cord-312955-gs65c3fy	390	11	Inflammasome	Inflammasome	NNP
cord-312955-gs65c3fy	390	12	Activation	Activation	NNP
cord-312955-gs65c3fy	390	13	Alpha	Alpha	NNP
cord-312955-gs65c3fy	390	14	/	/	SYM
cord-312955-gs65c3fy	390	15	beta	beta	NN
cord-312955-gs65c3fy	391	1	interferon	interferon	NN
cord-312955-gs65c3fy	391	2	receptor	receptor	NN
cord-312955-gs65c3fy	391	3	signaling	signaling	NN
cord-312955-gs65c3fy	391	4	amplifies	amplify	VBZ
cord-312955-gs65c3fy	391	5	early	early	JJ
cord-312955-gs65c3fy	391	6	proinflammatory	proinflammatory	JJ
cord-312955-gs65c3fy	391	7	cytokine	cytokine	NN
cord-312955-gs65c3fy	391	8	production	production	NN
cord-312955-gs65c3fy	391	9	in	in	IN
cord-312955-gs65c3fy	391	10	the	the	DT
cord-312955-gs65c3fy	391	11	lung	lung	NN
cord-312955-gs65c3fy	391	12	during	during	IN
cord-312955-gs65c3fy	391	13	respiratory	respiratory	JJ
cord-312955-gs65c3fy	391	14	syncytial	syncytial	JJ
cord-312955-gs65c3fy	391	15	virus	virus	NN
cord-312955-gs65c3fy	391	16	infection	infection	NN
cord-312955-gs65c3fy	391	17	Type	type	NN
cord-312955-gs65c3fy	391	18	I	-PRON-	PRP
cord-312955-gs65c3fy	391	19	interferons	interferon	NNS
cord-312955-gs65c3fy	391	20	as	as	IN
cord-312955-gs65c3fy	391	21	regulators	regulator	NNS
cord-312955-gs65c3fy	391	22	of	of	IN
cord-312955-gs65c3fy	391	23	lung	lung	NN
cord-312955-gs65c3fy	391	24	inflammation	inflammation	NN
cord-312955-gs65c3fy	391	25	Ubiquitination	Ubiquitination	NNP
cord-312955-gs65c3fy	391	26	-	-	HYPH
cord-312955-gs65c3fy	391	27	mediated	mediate	VBN
cord-312955-gs65c3fy	391	28	regulation	regulation	NN
cord-312955-gs65c3fy	391	29	of	of	IN
cord-312955-gs65c3fy	391	30	interferon	interferon	NN
cord-312955-gs65c3fy	391	31	responses	response	NNS
cord-312955-gs65c3fy	391	32	Viral	viral	JJ
cord-312955-gs65c3fy	391	33	dedication	dedication	NN
cord-312955-gs65c3fy	391	34	to	to	IN
cord-312955-gs65c3fy	391	35	vigorous	vigorous	JJ
cord-312955-gs65c3fy	391	36	destruction	destruction	NN
cord-312955-gs65c3fy	391	37	of	of	IN
cord-312955-gs65c3fy	391	38	interferon	interferon	NN
cord-312955-gs65c3fy	391	39	receptors	receptor	NNS
cord-312955-gs65c3fy	391	40	Immunopathogenesis	Immunopathogenesis	NNP
cord-312955-gs65c3fy	391	41	of	of	IN
cord-312955-gs65c3fy	391	42	coronavirus	coronavirus	NN
cord-312955-gs65c3fy	391	43	infections	infection	NNS
cord-312955-gs65c3fy	391	44	:	:	:
cord-312955-gs65c3fy	391	45	implications	implication	NNS
cord-312955-gs65c3fy	391	46	for	for	IN
cord-312955-gs65c3fy	391	47	SARS	SARS	NNP
cord-312955-gs65c3fy	391	48	Pathogenic	Pathogenic	NNP
cord-312955-gs65c3fy	391	49	human	human	JJ
cord-312955-gs65c3fy	391	50	coronavirus	coronavirus	NN
cord-312955-gs65c3fy	391	51	infections	infection	NNS
cord-312955-gs65c3fy	391	52	:	:	:
cord-312955-gs65c3fy	391	53	causes	cause	NNS
cord-312955-gs65c3fy	391	54	and	and	CC
cord-312955-gs65c3fy	391	55	consequences	consequence	NNS
cord-312955-gs65c3fy	391	56	of	of	IN
cord-312955-gs65c3fy	391	57	cytokine	cytokine	NN
cord-312955-gs65c3fy	391	58	storm	storm	NN
cord-312955-gs65c3fy	391	59	and	and	CC
cord-312955-gs65c3fy	391	60	immunopathology	immunopathology	NN
cord-312955-gs65c3fy	391	61	Severe	severe	JJ
cord-312955-gs65c3fy	391	62	acute	acute	JJ
cord-312955-gs65c3fy	391	63	respiratory	respiratory	JJ
cord-312955-gs65c3fy	391	64	syndrome	syndrome	NN
cord-312955-gs65c3fy	391	65	coronavirus	coronavirus	NN
cord-312955-gs65c3fy	391	66	ORF6	ORF6	NNP
cord-312955-gs65c3fy	391	67	antagonizes	antagonize	VBZ
cord-312955-gs65c3fy	391	68	STAT1	stat1	NN
cord-312955-gs65c3fy	391	69	function	function	NN
cord-312955-gs65c3fy	391	70	by	by	IN
cord-312955-gs65c3fy	391	71	sequestering	sequester	VBG
cord-312955-gs65c3fy	391	72	nuclear	nuclear	JJ
cord-312955-gs65c3fy	391	73	import	import	NN
cord-312955-gs65c3fy	391	74	factors	factor	NNS
cord-312955-gs65c3fy	391	75	on	on	IN
cord-312955-gs65c3fy	391	76	the	the	DT
cord-312955-gs65c3fy	391	77	rough	rough	JJ
cord-312955-gs65c3fy	391	78	endoplasmic	endoplasmic	NN
cord-312955-gs65c3fy	391	79	reticulum	reticulum	NN
cord-312955-gs65c3fy	391	80	/	/	SYM
cord-312955-gs65c3fy	391	81	Golgi	Golgi	NNP
cord-312955-gs65c3fy	391	82	membrane	membrane	NN
cord-312955-gs65c3fy	391	83	Coronavirus	Coronavirus	NNP
cord-312955-gs65c3fy	391	84	papain	papain	NN
cord-312955-gs65c3fy	391	85	-	-	HYPH
cord-312955-gs65c3fy	391	86	like	like	JJ
cord-312955-gs65c3fy	391	87	proteases	protease	NNS
cord-312955-gs65c3fy	391	88	negatively	negatively	RB
cord-312955-gs65c3fy	391	89	regulate	regulate	VBP
cord-312955-gs65c3fy	391	90	antiviral	antiviral	JJ
cord-312955-gs65c3fy	391	91	innate	innate	JJ
cord-312955-gs65c3fy	391	92	immune	immune	JJ
cord-312955-gs65c3fy	391	93	response	response	NN
cord-312955-gs65c3fy	391	94	through	through	IN
cord-312955-gs65c3fy	391	95	disruption	disruption	NN
cord-312955-gs65c3fy	391	96	of	of	IN
cord-312955-gs65c3fy	391	97	STING	sting	NN
cord-312955-gs65c3fy	391	98	-	-	HYPH
cord-312955-gs65c3fy	391	99	mediated	mediate	VBN
cord-312955-gs65c3fy	391	100	signaling	signal	VBG
cord-312955-gs65c3fy	391	101	Structural	Structural	NNP
cord-312955-gs65c3fy	391	102	Insights	Insights	NNPS
cord-312955-gs65c3fy	391	103	into	into	IN
cord-312955-gs65c3fy	391	104	the	the	DT
cord-312955-gs65c3fy	391	105	Interaction	Interaction	NNP
cord-312955-gs65c3fy	391	106	of	of	IN
cord-312955-gs65c3fy	391	107	Coronavirus	Coronavirus	NNP
cord-312955-gs65c3fy	391	108	Papain	Papain	NNP
cord-312955-gs65c3fy	391	109	-	-	HYPH
cord-312955-gs65c3fy	391	110	Like	Like	NNP
cord-312955-gs65c3fy	391	111	Proteases	Proteases	NNP
cord-312955-gs65c3fy	391	112	and	and	CC
cord-312955-gs65c3fy	391	113	Interferon	Interferon	NNP
cord-312955-gs65c3fy	391	114	-	-	HYPH
cord-312955-gs65c3fy	391	115	Stimulated	stimulate	VBN
cord-312955-gs65c3fy	391	116	Gene	Gene	NNP
cord-312955-gs65c3fy	391	117	Product	Product	NNP
cord-312955-gs65c3fy	391	118	15	15	CD
cord-312955-gs65c3fy	391	119	from	from	IN
cord-312955-gs65c3fy	391	120	Different	different	JJ
cord-312955-gs65c3fy	391	121	Species	specie	NNS
cord-312955-gs65c3fy	392	1	Middle	Middle	NNP
cord-312955-gs65c3fy	392	2	East	East	NNP
cord-312955-gs65c3fy	392	3	respiratory	respiratory	JJ
cord-312955-gs65c3fy	392	4	syndrome	syndrome	NN
cord-312955-gs65c3fy	392	5	coronavirus	coronavirus	NN
cord-312955-gs65c3fy	392	6	ORF4b	orf4b	NN
cord-312955-gs65c3fy	392	7	protein	protein	NN
cord-312955-gs65c3fy	392	8	inhibits	inhibit	VBZ
cord-312955-gs65c3fy	392	9	type	type	NN
cord-312955-gs65c3fy	393	1	I	-PRON-	PRP
cord-312955-gs65c3fy	394	1	interferon	interferon	NN
cord-312955-gs65c3fy	394	2	production	production	NN
cord-312955-gs65c3fy	394	3	through	through	IN
cord-312955-gs65c3fy	394	4	both	both	CC
cord-312955-gs65c3fy	394	5	cytoplasmic	cytoplasmic	JJ
cord-312955-gs65c3fy	394	6	and	and	CC
cord-312955-gs65c3fy	394	7	nuclear	nuclear	JJ
cord-312955-gs65c3fy	394	8	targets	target	NNS
cord-312955-gs65c3fy	395	1	Dynamic	dynamic	JJ
cord-312955-gs65c3fy	395	2	innate	innate	JJ
cord-312955-gs65c3fy	395	3	immune	immune	JJ
cord-312955-gs65c3fy	395	4	responses	response	NNS
cord-312955-gs65c3fy	395	5	of	of	IN
cord-312955-gs65c3fy	395	6	human	human	JJ
cord-312955-gs65c3fy	395	7	bronchial	bronchial	JJ
cord-312955-gs65c3fy	395	8	epithelial	epithelial	JJ
cord-312955-gs65c3fy	395	9	cells	cell	NNS
cord-312955-gs65c3fy	395	10	to	to	IN
cord-312955-gs65c3fy	396	1	severe	severe	JJ
cord-312955-gs65c3fy	396	2	acute	acute	JJ
cord-312955-gs65c3fy	396	3	respiratory	respiratory	JJ
cord-312955-gs65c3fy	396	4	syndrome	syndrome	NN
cord-312955-gs65c3fy	396	5	-	-	HYPH
cord-312955-gs65c3fy	396	6	associated	associate	VBN
cord-312955-gs65c3fy	396	7	coronavirus	coronavirus	NN
cord-312955-gs65c3fy	396	8	infection	infection	NN
cord-312955-gs65c3fy	396	9	A	a	DT
cord-312955-gs65c3fy	396	10	review	review	NN
cord-312955-gs65c3fy	396	11	of	of	IN
cord-312955-gs65c3fy	396	12	treatment	treatment	NN
cord-312955-gs65c3fy	396	13	modalities	modality	NNS
cord-312955-gs65c3fy	396	14	for	for	IN
cord-312955-gs65c3fy	396	15	Middle	Middle	NNP
cord-312955-gs65c3fy	396	16	East	East	NNP
cord-312955-gs65c3fy	396	17	Respiratory	Respiratory	NNP
cord-312955-gs65c3fy	396	18	Syndrome	Syndrome	NNP
cord-312955-gs65c3fy	396	19	SARS	SARS	NNP
cord-312955-gs65c3fy	396	20	:	:	:
cord-312955-gs65c3fy	396	21	systematic	systematic	JJ
cord-312955-gs65c3fy	396	22	review	review	NN
cord-312955-gs65c3fy	396	23	of	of	IN
cord-312955-gs65c3fy	396	24	treatment	treatment	NN
cord-312955-gs65c3fy	396	25	effects	effect	NNS
cord-312955-gs65c3fy	396	26	Effect	effect	NN
cord-312955-gs65c3fy	396	27	of	of	IN
cord-312955-gs65c3fy	396	28	Intravenous	Intravenous	NNP
cord-312955-gs65c3fy	396	29	Interferon	Interferon	NNP
cord-312955-gs65c3fy	396	30	b-1a	b-1a	NN
cord-312955-gs65c3fy	396	31	on	on	IN
cord-312955-gs65c3fy	396	32	Death	death	NN
cord-312955-gs65c3fy	396	33	and	and	CC
cord-312955-gs65c3fy	396	34	Days	day	NNS
cord-312955-gs65c3fy	397	1	Free	free	JJ
cord-312955-gs65c3fy	397	2	From	from	IN
cord-312955-gs65c3fy	397	3	Mechanical	Mechanical	NNP
cord-312955-gs65c3fy	397	4	Ventilation	Ventilation	NNP
cord-312955-gs65c3fy	398	1	Among	among	IN
cord-312955-gs65c3fy	398	2	Patients	patient	NNS
cord-312955-gs65c3fy	398	3	With	with	IN
cord-312955-gs65c3fy	398	4	Moderate	moderate	JJ
cord-312955-gs65c3fy	398	5	to	to	IN
cord-312955-gs65c3fy	398	6	Severe	severe	JJ
cord-312955-gs65c3fy	398	7	Acute	acute	JJ
cord-312955-gs65c3fy	398	8	Respiratory	respiratory	JJ
cord-312955-gs65c3fy	398	9	Distress	Distress	NNP
cord-312955-gs65c3fy	398	10	Syndrome	Syndrome	NNP
cord-312955-gs65c3fy	398	11	:	:	:
cord-312955-gs65c3fy	399	1	A	a	DT
cord-312955-gs65c3fy	399	2	Randomized	Randomized	NNP
cord-312955-gs65c3fy	399	3	Clinical	Clinical	NNP
cord-312955-gs65c3fy	399	4	Trial	Trial	NNP
cord-312955-gs65c3fy	399	5	Dysregulated	Dysregulated	NNP
cord-312955-gs65c3fy	399	6	Type	Type	NNP
cord-312955-gs65c3fy	400	1	I	-PRON-	PRP
cord-312955-gs65c3fy	401	1	Interferon	interferon	NN
cord-312955-gs65c3fy	401	2	and	and	CC
cord-312955-gs65c3fy	401	3	Inflammatory	inflammatory	JJ
cord-312955-gs65c3fy	401	4	Monocyte	Monocyte	NNP
cord-312955-gs65c3fy	401	5	-	-	HYPH
cord-312955-gs65c3fy	401	6	Macrophage	Macrophage	NNP
cord-312955-gs65c3fy	401	7	Responses	response	NNS
cord-312955-gs65c3fy	402	1	Cause	cause	VB
cord-312955-gs65c3fy	402	2	Lethal	lethal	JJ
cord-312955-gs65c3fy	402	3	Pneumonia	pneumonia	NN
cord-312955-gs65c3fy	402	4	in	in	IN
cord-312955-gs65c3fy	402	5	SARS	SARS	NNP
cord-312955-gs65c3fy	402	6	-	-	HYPH
cord-312955-gs65c3fy	402	7	CoV	CoV	NNP
cord-312955-gs65c3fy	402	8	-	-	HYPH
cord-312955-gs65c3fy	402	9	Infected	infected	JJ
cord-312955-gs65c3fy	402	10	Mice	mouse	NNS
cord-312955-gs65c3fy	402	11	IFN-	IFN-	NNP
cord-312955-gs65c3fy	403	1	I	-PRON-	PRP
cord-312955-gs65c3fy	403	2	response	response	VBP
cord-312955-gs65c3fy	403	3	timing	timing	NN
cord-312955-gs65c3fy	403	4	relative	relative	JJ
cord-312955-gs65c3fy	403	5	to	to	IN
cord-312955-gs65c3fy	403	6	virus	virus	NN
cord-312955-gs65c3fy	403	7	replication	replication	NN
cord-312955-gs65c3fy	403	8	determines	determine	VBZ
cord-312955-gs65c3fy	403	9	MERS	MERS	NNP
cord-312955-gs65c3fy	403	10	coronavirus	coronavirus	NN
cord-312955-gs65c3fy	403	11	infection	infection	NN
cord-312955-gs65c3fy	403	12	outcomes	outcome	NNS
cord-312955-gs65c3fy	403	13	Age	age	NN
cord-312955-gs65c3fy	403	14	-	-	HYPH
cord-312955-gs65c3fy	403	15	dependent	dependent	JJ
cord-312955-gs65c3fy	403	16	effects	effect	NNS
cord-312955-gs65c3fy	403	17	in	in	IN
cord-312955-gs65c3fy	403	18	the	the	DT
cord-312955-gs65c3fy	403	19	transmission	transmission	NN
cord-312955-gs65c3fy	403	20	and	and	CC
cord-312955-gs65c3fy	403	21	control	control	NN
cord-312955-gs65c3fy	403	22	of	of	IN
cord-312955-gs65c3fy	403	23	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	403	24	epidemics	epidemic	NNS
cord-312955-gs65c3fy	403	25	SARS	SARS	NNP
cord-312955-gs65c3fy	403	26	-	-	HYPH
cord-312955-gs65c3fy	403	27	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	403	28	Cell	Cell	NNP
cord-312955-gs65c3fy	403	29	Entry	entry	NN
cord-312955-gs65c3fy	403	30	Depends	depend	VBZ
cord-312955-gs65c3fy	403	31	on	on	IN
cord-312955-gs65c3fy	403	32	ACE2	ACE2	NNP
cord-312955-gs65c3fy	403	33	and	and	CC
cord-312955-gs65c3fy	403	34	TMPRSS2	TMPRSS2	NNP
cord-312955-gs65c3fy	403	35	and	and	CC
cord-312955-gs65c3fy	404	1	Is	be	VBZ
cord-312955-gs65c3fy	404	2	Blocked	block	VBN
cord-312955-gs65c3fy	404	3	by	by	IN
cord-312955-gs65c3fy	404	4	a	a	DT
cord-312955-gs65c3fy	404	5	Clinically	clinically	RB
cord-312955-gs65c3fy	404	6	Proven	prove	VBN
cord-312955-gs65c3fy	404	7	Protease	protease	NN
cord-312955-gs65c3fy	404	8	Inhibitor	Inhibitor	NNP
cord-312955-gs65c3fy	404	9	Cryo	Cryo	NNP
cord-312955-gs65c3fy	404	10	-	-	HYPH
cord-312955-gs65c3fy	404	11	EM	EM	NNP
cord-312955-gs65c3fy	404	12	structure	structure	NN
cord-312955-gs65c3fy	404	13	of	of	IN
cord-312955-gs65c3fy	404	14	the	the	DT
cord-312955-gs65c3fy	404	15	2019-nCoV	2019-ncov	CD
cord-312955-gs65c3fy	404	16	spike	spike	NN
cord-312955-gs65c3fy	404	17	in	in	IN
cord-312955-gs65c3fy	404	18	the	the	DT
cord-312955-gs65c3fy	404	19	prefusion	prefusion	NN
cord-312955-gs65c3fy	404	20	conformation	conformation	NN
cord-312955-gs65c3fy	404	21	Characterization	characterization	NN
cord-312955-gs65c3fy	404	22	of	of	IN
cord-312955-gs65c3fy	404	23	the	the	DT
cord-312955-gs65c3fy	404	24	receptor	receptor	NN
cord-312955-gs65c3fy	404	25	-	-	HYPH
cord-312955-gs65c3fy	404	26	binding	bind	VBG
cord-312955-gs65c3fy	404	27	domain	domain	NN
cord-312955-gs65c3fy	404	28	(	(	-LRB-
cord-312955-gs65c3fy	404	29	RBD	RBD	NNP
cord-312955-gs65c3fy	404	30	)	)	-RRB-
cord-312955-gs65c3fy	404	31	of	of	IN
cord-312955-gs65c3fy	404	32	2019	2019	CD
cord-312955-gs65c3fy	404	33	novel	novel	JJ
cord-312955-gs65c3fy	404	34	coronavirus	coronavirus	NN
cord-312955-gs65c3fy	404	35	:	:	:
cord-312955-gs65c3fy	404	36	implication	implication	NN
cord-312955-gs65c3fy	404	37	for	for	IN
cord-312955-gs65c3fy	404	38	development	development	NN
cord-312955-gs65c3fy	404	39	of	of	IN
cord-312955-gs65c3fy	404	40	RBD	RBD	NNP
cord-312955-gs65c3fy	404	41	protein	protein	NN
cord-312955-gs65c3fy	404	42	as	as	IN
cord-312955-gs65c3fy	404	43	a	a	DT
cord-312955-gs65c3fy	404	44	viral	viral	JJ
cord-312955-gs65c3fy	404	45	attachment	attachment	NN
cord-312955-gs65c3fy	404	46	inhibitor	inhibitor	NN
cord-312955-gs65c3fy	404	47	and	and	CC
cord-312955-gs65c3fy	404	48	vaccine	vaccine	NN
cord-312955-gs65c3fy	404	49	Specific	specific	JJ
cord-312955-gs65c3fy	404	50	viral	viral	JJ
cord-312955-gs65c3fy	404	51	RNA	RNA	NNP
cord-312955-gs65c3fy	404	52	drives	drive	VBZ
cord-312955-gs65c3fy	404	53	the	the	DT
cord-312955-gs65c3fy	404	54	SARS	SARS	NNP
cord-312955-gs65c3fy	404	55	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	404	56	nucleocapsid	nucleocapsid	NN
cord-312955-gs65c3fy	404	57	to	to	TO
cord-312955-gs65c3fy	404	58	phase	phase	VB
cord-312955-gs65c3fy	404	59	separate	separate	JJ
cord-312955-gs65c3fy	405	1	The	the	DT
cord-312955-gs65c3fy	405	2	SARS	SARS	NNP
cord-312955-gs65c3fy	405	3	-	-	HYPH
cord-312955-gs65c3fy	405	4	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	405	5	nucleocapsid	nucleocapsid	NN
cord-312955-gs65c3fy	405	6	protein	protein	NN
cord-312955-gs65c3fy	405	7	is	be	VBZ
cord-312955-gs65c3fy	405	8	dynamic	dynamic	JJ
cord-312955-gs65c3fy	405	9	,	,	,
cord-312955-gs65c3fy	405	10	disordered	disordered	JJ
cord-312955-gs65c3fy	405	11	,	,	,
cord-312955-gs65c3fy	405	12	and	and	CC
cord-312955-gs65c3fy	405	13	phase	phase	NN
cord-312955-gs65c3fy	405	14	separates	separate	VBZ
cord-312955-gs65c3fy	405	15	with	with	IN
cord-312955-gs65c3fy	405	16	RNA	RNA	NNP
cord-312955-gs65c3fy	405	17	SARS	SARS	NNP
cord-312955-gs65c3fy	405	18	-	-	HYPH
cord-312955-gs65c3fy	405	19	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	405	20	receptor	receptor	NN
cord-312955-gs65c3fy	405	21	ACE2	ACE2	NNP
cord-312955-gs65c3fy	405	22	and	and	CC
cord-312955-gs65c3fy	405	23	TMPRSS2	TMPRSS2	NNP
cord-312955-gs65c3fy	405	24	are	be	VBP
cord-312955-gs65c3fy	405	25	primarily	primarily	RB
cord-312955-gs65c3fy	405	26	expressed	express	VBN
cord-312955-gs65c3fy	405	27	in	in	IN
cord-312955-gs65c3fy	405	28	bronchial	bronchial	JJ
cord-312955-gs65c3fy	405	29	transient	transient	JJ
cord-312955-gs65c3fy	405	30	secretory	secretory	NN
cord-312955-gs65c3fy	405	31	cells	cell	NNS
cord-312955-gs65c3fy	406	1	SARS	SARS	NNP
cord-312955-gs65c3fy	406	2	-	-	HYPH
cord-312955-gs65c3fy	406	3	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	406	4	Receptor	Receptor	NNP
cord-312955-gs65c3fy	406	5	ACE2	ACE2	NNP
cord-312955-gs65c3fy	406	6	Is	be	VBZ
cord-312955-gs65c3fy	406	7	an	an	DT
cord-312955-gs65c3fy	406	8	Interferon	Interferon	NNP
cord-312955-gs65c3fy	406	9	-	-	HYPH
cord-312955-gs65c3fy	406	10	Stimulated	stimulate	VBN
cord-312955-gs65c3fy	406	11	Gene	Gene	NNP
cord-312955-gs65c3fy	406	12	in	in	IN
cord-312955-gs65c3fy	406	13	Human	Human	NNP
cord-312955-gs65c3fy	406	14	Airway	Airway	NNP
cord-312955-gs65c3fy	406	15	Epithelial	Epithelial	NNP
cord-312955-gs65c3fy	406	16	Cells	cell	NNS
cord-312955-gs65c3fy	406	17	and	and	CC
cord-312955-gs65c3fy	406	18	Is	be	VBZ
cord-312955-gs65c3fy	406	19	Detected	detect	VBN
cord-312955-gs65c3fy	406	20	in	in	IN
cord-312955-gs65c3fy	406	21	Specific	specific	JJ
cord-312955-gs65c3fy	406	22	Cell	cell	NN
cord-312955-gs65c3fy	406	23	Subsets	subset	NNS
cord-312955-gs65c3fy	406	24	across	across	IN
cord-312955-gs65c3fy	406	25	Tissues	Tissues	NNP
cord-312955-gs65c3fy	406	26	SARS	SARS	NNP
cord-312955-gs65c3fy	406	27	-	-	HYPH
cord-312955-gs65c3fy	406	28	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	407	1	entry	entry	NN
cord-312955-gs65c3fy	407	2	factors	factor	NNS
cord-312955-gs65c3fy	407	3	are	be	VBP
cord-312955-gs65c3fy	407	4	highly	highly	RB
cord-312955-gs65c3fy	407	5	expressed	express	VBN
cord-312955-gs65c3fy	407	6	in	in	IN
cord-312955-gs65c3fy	407	7	nasal	nasal	JJ
cord-312955-gs65c3fy	407	8	epithelial	epithelial	JJ
cord-312955-gs65c3fy	407	9	cells	cell	NNS
cord-312955-gs65c3fy	407	10	together	together	RB
cord-312955-gs65c3fy	407	11	with	with	IN
cord-312955-gs65c3fy	407	12	innate	innate	JJ
cord-312955-gs65c3fy	407	13	immune	immune	JJ
cord-312955-gs65c3fy	407	14	genes	gene	NNS
cord-312955-gs65c3fy	407	15	Pathogenesis	Pathogenesis	NNP
cord-312955-gs65c3fy	407	16	of	of	IN
cord-312955-gs65c3fy	407	17	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	407	18	from	from	IN
cord-312955-gs65c3fy	407	19	a	a	DT
cord-312955-gs65c3fy	407	20	cell	cell	NN
cord-312955-gs65c3fy	407	21	biology	biology	NN
cord-312955-gs65c3fy	407	22	perspective	perspective	NN
cord-312955-gs65c3fy	408	1	SARS	SARS	NNP
cord-312955-gs65c3fy	408	2	-	-	HYPH
cord-312955-gs65c3fy	408	3	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	408	4	is	be	VBZ
cord-312955-gs65c3fy	408	5	sensitive	sensitive	JJ
cord-312955-gs65c3fy	408	6	to	to	TO
cord-312955-gs65c3fy	408	7	type	type	NN
cord-312955-gs65c3fy	408	8	I	-PRON-	PRP
cord-312955-gs65c3fy	408	9	interferon	interferon	NN
cord-312955-gs65c3fy	408	10	pretreatment	pretreatment	NN
cord-312955-gs65c3fy	408	11	Sensing	Sensing	NNP
cord-312955-gs65c3fy	408	12	of	of	IN
cord-312955-gs65c3fy	408	13	RNA	RNA	NNP
cord-312955-gs65c3fy	408	14	viruses	virus	NNS
cord-312955-gs65c3fy	408	15	:	:	:
cord-312955-gs65c3fy	408	16	a	a	DT
cord-312955-gs65c3fy	408	17	review	review	NN
cord-312955-gs65c3fy	408	18	of	of	IN
cord-312955-gs65c3fy	408	19	innate	innate	JJ
cord-312955-gs65c3fy	408	20	immune	immune	JJ
cord-312955-gs65c3fy	408	21	receptors	receptor	NNS
cord-312955-gs65c3fy	408	22	involved	involve	VBN
cord-312955-gs65c3fy	408	23	in	in	IN
cord-312955-gs65c3fy	408	24	recognizing	recognize	VBG
cord-312955-gs65c3fy	408	25	RNA	RNA	NNP
cord-312955-gs65c3fy	408	26	virus	virus	NN
cord-312955-gs65c3fy	408	27	invasion	invasion	NN
cord-312955-gs65c3fy	408	28	SARS	SARS	NNP
cord-312955-gs65c3fy	408	29	-	-	HYPH
cord-312955-gs65c3fy	408	30	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	408	31	nsp13	nsp13	NNP
cord-312955-gs65c3fy	408	32	,	,	,
cord-312955-gs65c3fy	409	1	nsp14	nsp14	UH
cord-312955-gs65c3fy	409	2	,	,	,
cord-312955-gs65c3fy	409	3	nsp15	nsp15	''
cord-312955-gs65c3fy	409	4	and	and	CC
cord-312955-gs65c3fy	409	5	orf6	orf6	DT
cord-312955-gs65c3fy	409	6	function	function	NN
cord-312955-gs65c3fy	409	7	as	as	IN
cord-312955-gs65c3fy	409	8	potent	potent	JJ
cord-312955-gs65c3fy	409	9	interferon	interferon	NN
cord-312955-gs65c3fy	409	10	antagonists	antagonist	NNS
cord-312955-gs65c3fy	409	11	Activation	Activation	NNP
cord-312955-gs65c3fy	409	12	and	and	CC
cord-312955-gs65c3fy	409	13	evasion	evasion	NN
cord-312955-gs65c3fy	409	14	of	of	IN
cord-312955-gs65c3fy	409	15	type	type	NN
cord-312955-gs65c3fy	410	1	I	-PRON-	PRP
cord-312955-gs65c3fy	411	1	interferon	interferon	NN
cord-312955-gs65c3fy	411	2	responses	response	NNS
cord-312955-gs65c3fy	411	3	by	by	IN
cord-312955-gs65c3fy	411	4	SARS	SARS	NNP
cord-312955-gs65c3fy	411	5	-	-	HYPH
cord-312955-gs65c3fy	411	6	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	411	7	The	the	DT
cord-312955-gs65c3fy	411	8	ORF6	ORF6	NNP
cord-312955-gs65c3fy	411	9	,	,	,
cord-312955-gs65c3fy	411	10	ORF8	ORF8	NNP
cord-312955-gs65c3fy	411	11	and	and	CC
cord-312955-gs65c3fy	411	12	nucleocapsid	nucleocapsid	NN
cord-312955-gs65c3fy	411	13	proteins	protein	NNS
cord-312955-gs65c3fy	411	14	of	of	IN
cord-312955-gs65c3fy	411	15	SARS	SARS	NNP
cord-312955-gs65c3fy	411	16	-	-	HYPH
cord-312955-gs65c3fy	411	17	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	411	18	inhibit	inhibit	NN
cord-312955-gs65c3fy	411	19	type	type	NN
cord-312955-gs65c3fy	412	1	I	-PRON-	PRP
cord-312955-gs65c3fy	412	2	interferon	interferon	RB
cord-312955-gs65c3fy	412	3	signaling	signal	VBG
cord-312955-gs65c3fy	413	1	pathway	pathway	NNP
cord-312955-gs65c3fy	413	2	SARS	SARS	NNP
cord-312955-gs65c3fy	413	3	-	-	HYPH
cord-312955-gs65c3fy	413	4	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	414	1	ORF3b	ORF3b	NNP
cord-312955-gs65c3fy	414	2	is	be	VBZ
cord-312955-gs65c3fy	414	3	a	a	DT
cord-312955-gs65c3fy	414	4	potent	potent	JJ
cord-312955-gs65c3fy	414	5	interferon	interferon	NN
cord-312955-gs65c3fy	414	6	antagonist	antagonist	NN
cord-312955-gs65c3fy	414	7	whose	whose	WP$
cord-312955-gs65c3fy	414	8	activity	activity	NN
cord-312955-gs65c3fy	414	9	is	be	VBZ
cord-312955-gs65c3fy	414	10	further	far	RBR
cord-312955-gs65c3fy	414	11	increased	increase	VBN
cord-312955-gs65c3fy	414	12	by	by	IN
cord-312955-gs65c3fy	414	13	a	a	DT
cord-312955-gs65c3fy	414	14	naturally	naturally	RB
cord-312955-gs65c3fy	414	15	occurring	occur	VBG
cord-312955-gs65c3fy	414	16	elongation	elongation	NN
cord-312955-gs65c3fy	414	17	variant	variant	NN
cord-312955-gs65c3fy	414	18	The	the	DT
cord-312955-gs65c3fy	414	19	coding	code	VBG
cord-312955-gs65c3fy	414	20	capacity	capacity	NN
cord-312955-gs65c3fy	414	21	of	of	IN
cord-312955-gs65c3fy	414	22	SARS	SARS	NNP
cord-312955-gs65c3fy	414	23	-	-	HYPH
cord-312955-gs65c3fy	414	24	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	415	1	Papain	papain	NN
cord-312955-gs65c3fy	415	2	-	-	HYPH
cord-312955-gs65c3fy	415	3	like	like	JJ
cord-312955-gs65c3fy	415	4	protease	protease	NN
cord-312955-gs65c3fy	415	5	regulates	regulate	VBZ
cord-312955-gs65c3fy	415	6	SARS	SARS	NNP
cord-312955-gs65c3fy	415	7	-	-	HYPH
cord-312955-gs65c3fy	415	8	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	415	9	viral	viral	JJ
cord-312955-gs65c3fy	415	10	spread	spread	NN
cord-312955-gs65c3fy	415	11	and	and	CC
cord-312955-gs65c3fy	415	12	innate	innate	JJ
cord-312955-gs65c3fy	415	13	immunity	immunity	NN
cord-312955-gs65c3fy	415	14	Impaired	impair	VBN
cord-312955-gs65c3fy	415	15	type	type	NN
cord-312955-gs65c3fy	416	1	I	-PRON-	PRP
cord-312955-gs65c3fy	416	2	interferon	interferon	VBD
cord-312955-gs65c3fy	416	3	activity	activity	NN
cord-312955-gs65c3fy	416	4	and	and	CC
cord-312955-gs65c3fy	416	5	inflammatory	inflammatory	JJ
cord-312955-gs65c3fy	416	6	responses	response	NNS
cord-312955-gs65c3fy	416	7	in	in	IN
cord-312955-gs65c3fy	416	8	severe	severe	JJ
cord-312955-gs65c3fy	416	9	COVID-19	covid-19	JJ
cord-312955-gs65c3fy	416	10	patients	patient	NNS
cord-312955-gs65c3fy	416	11	Imbalanced	Imbalanced	NNP
cord-312955-gs65c3fy	416	12	Host	Host	NNP
cord-312955-gs65c3fy	416	13	Response	Response	NNP
cord-312955-gs65c3fy	416	14	to	to	IN
cord-312955-gs65c3fy	416	15	SARS	SARS	NNP
cord-312955-gs65c3fy	416	16	-	-	HYPH
cord-312955-gs65c3fy	416	17	CoV-2	CoV-2	NNP
cord-312955-gs65c3fy	417	1	Drives	drive	VBZ
cord-312955-gs65c3fy	417	2	Development	Development	NNP
cord-312955-gs65c3fy	417	3	of	of	IN
cord-312955-gs65c3fy	417	4	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	417	5	Dysregulation	Dysregulation	NNP
cord-312955-gs65c3fy	417	6	of	of	IN
cord-312955-gs65c3fy	417	7	type	type	NN
cord-312955-gs65c3fy	418	1	I	-PRON-	PRP
cord-312955-gs65c3fy	419	1	interferon	interferon	NN
cord-312955-gs65c3fy	419	2	responses	response	NNS
cord-312955-gs65c3fy	419	3	in	in	IN
cord-312955-gs65c3fy	419	4	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	419	5	Reduction	Reduction	NNP
cord-312955-gs65c3fy	419	6	and	and	CC
cord-312955-gs65c3fy	419	7	Functional	functional	JJ
cord-312955-gs65c3fy	419	8	Exhaustion	exhaustion	NN
cord-312955-gs65c3fy	419	9	of	of	IN
cord-312955-gs65c3fy	419	10	T	T	NNP
cord-312955-gs65c3fy	419	11	Cells	cell	NNS
cord-312955-gs65c3fy	419	12	in	in	IN
cord-312955-gs65c3fy	419	13	Patients	patient	NNS
cord-312955-gs65c3fy	419	14	With	with	IN
cord-312955-gs65c3fy	419	15	Coronavirus	Coronavirus	NNP
cord-312955-gs65c3fy	419	16	Disease	Disease	NNP
cord-312955-gs65c3fy	419	17	2019	2019	CD
cord-312955-gs65c3fy	419	18	(	(	-LRB-
cord-312955-gs65c3fy	419	19	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	419	20	)	)	-RRB-
cord-312955-gs65c3fy	419	21	Dysregulation	Dysregulation	NNP
cord-312955-gs65c3fy	419	22	of	of	IN
cord-312955-gs65c3fy	419	23	the	the	DT
cord-312955-gs65c3fy	419	24	immune	immune	JJ
cord-312955-gs65c3fy	419	25	response	response	NN
cord-312955-gs65c3fy	419	26	affects	affect	VBZ
cord-312955-gs65c3fy	419	27	the	the	DT
cord-312955-gs65c3fy	419	28	outcome	outcome	NN
cord-312955-gs65c3fy	419	29	of	of	IN
cord-312955-gs65c3fy	419	30	critical	critical	JJ
cord-312955-gs65c3fy	419	31	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	419	32	patients	patient	NNS
cord-312955-gs65c3fy	419	33	Dysregulation	Dysregulation	NNP
cord-312955-gs65c3fy	419	34	of	of	IN
cord-312955-gs65c3fy	419	35	immune	immune	JJ
cord-312955-gs65c3fy	419	36	response	response	NN
cord-312955-gs65c3fy	419	37	in	in	IN
cord-312955-gs65c3fy	419	38	patients	patient	NNS
cord-312955-gs65c3fy	419	39	with	with	IN
cord-312955-gs65c3fy	419	40	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	419	41	in	in	IN
cord-312955-gs65c3fy	419	42	Wuhan	Wuhan	NNP
cord-312955-gs65c3fy	419	43	,	,	,
cord-312955-gs65c3fy	419	44	China	China	NNP
cord-312955-gs65c3fy	419	45	Comprehensive	Comprehensive	NNP
cord-312955-gs65c3fy	419	46	Transcriptomic	Transcriptomic	NNP
cord-312955-gs65c3fy	419	47	Analysis	Analysis	NNP
cord-312955-gs65c3fy	419	48	of	of	IN
cord-312955-gs65c3fy	419	49	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	419	50	Blood	Blood	NNP
cord-312955-gs65c3fy	419	51	Viral	viral	JJ
cord-312955-gs65c3fy	419	52	invasion	invasion	NN
cord-312955-gs65c3fy	419	53	and	and	CC
cord-312955-gs65c3fy	419	54	type	type	NN
cord-312955-gs65c3fy	420	1	i	i	PRP
cord-312955-gs65c3fy	421	1	interferon	interferon	NNP
cord-312955-gs65c3fy	421	2	response	response	NN
cord-312955-gs65c3fy	421	3	characterize	characterize	VBP
cord-312955-gs65c3fy	421	4	the	the	DT
cord-312955-gs65c3fy	421	5	immunophenotypes	immunophenotypes	NNPS
cord-312955-gs65c3fy	421	6	during	during	IN
cord-312955-gs65c3fy	421	7	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	421	8	infection	infection	NN
cord-312955-gs65c3fy	421	9	Type	type	NN
cord-312955-gs65c3fy	421	10	I	-PRON-	PRP
cord-312955-gs65c3fy	421	11	IFN	IFN	NNP
cord-312955-gs65c3fy	421	12	immunoprofiling	immunoprofile	VBG
cord-312955-gs65c3fy	421	13	in	in	IN
cord-312955-gs65c3fy	421	14	COVID-19	covid-19	CD
cord-312955-gs65c3fy	421	15	patients	patient	NNS
cord-312955-gs65c3fy	421	16	Mechanisms	mechanism	NNS
cord-312955-gs65c3fy	421	17	and	and	CC
cord-312955-gs65c3fy	421	18	implications	implication	NNS
cord-312955-gs65c3fy	421	19	of	of	IN
cord-312955-gs65c3fy	422	1	age	age	NN
cord-312955-gs65c3fy	422	2	-	-	HYPH
cord-312955-gs65c3fy	422	3	associated	associate	VBN
cord-312955-gs65c3fy	422	4	impaired	impair	VBN
cord-312955-gs65c3fy	422	5	innate	innate	JJ
cord-312955-gs65c3fy	422	6	interferon	interferon	NN
cord-312955-gs65c3fy	422	7	secretion	secretion	NN
cord-312955-gs65c3fy	422	8	by	by	IN
cord-312955-gs65c3fy	422	9	dendritic	dendritic	JJ
cord-312955-gs65c3fy	422	10	cells	cell	NNS
cord-312955-gs65c3fy	422	11	:	:	:
cord-312955-gs65c3fy	422	12	a	a	DT
cord-312955-gs65c3fy	422	13	mini	mini	JJ
cord-312955-gs65c3fy	422	14	-	-	JJ
cord-312955-gs65c3fy	422	15	review	review	JJ
cord-312955-gs65c3fy	422	16	Age	age	NN
cord-312955-gs65c3fy	422	17	-	-	HYPH
cord-312955-gs65c3fy	422	18	dependent	dependent	JJ
cord-312955-gs65c3fy	422	19	dysregulation	dysregulation	NN
cord-312955-gs65c3fy	422	20	of	of	IN
cord-312955-gs65c3fy	422	21	innate	innate	JJ
cord-312955-gs65c3fy	422	22	immunity	immunity	NN
cord-312955-gs65c3fy	422	23	Decreased	decrease	VBD
cord-312955-gs65c3fy	422	24	interferon	interferon	NN
cord-312955-gs65c3fy	422	25	-	-	:
cord-312955-gs65c3fy	422	26	a	a	NN
cord-312955-gs65c3fy	422	27	and	and	CC
cord-312955-gs65c3fy	422	28	interferon	interferon	NN
cord-312955-gs65c3fy	422	29	-	-	HYPH
cord-312955-gs65c3fy	422	30	b	b	NN
cord-312955-gs65c3fy	422	31	production	production	NN
cord-312955-gs65c3fy	422	32	in	in	IN
cord-312955-gs65c3fy	422	33	obesity	obesity	NN
cord-312955-gs65c3fy	422	34	and	and	CC
cord-312955-gs65c3fy	422	35	expression	expression	NN
cord-312955-gs65c3fy	422	36	of	of	IN
cord-312955-gs65c3fy	422	37	suppressor	suppressor	NN
cord-312955-gs65c3fy	422	38	of	of	IN
cord-312955-gs65c3fy	422	39	cytokine	cytokine	NN
cord-312955-gs65c3fy	422	40	signaling	signal	VBG
cord-312955-gs65c3fy	422	41	Intranasal	Intranasal	NNP
cord-312955-gs65c3fy	422	42	interferon	interferon	NN
cord-312955-gs65c3fy	422	43	as	as	IN
cord-312955-gs65c3fy	422	44	protection	protection	NN
cord-312955-gs65c3fy	422	45	against	against	IN
cord-312955-gs65c3fy	422	46	experimental	experimental	JJ
cord-312955-gs65c3fy	422	47	respiratory	respiratory	JJ
cord-312955-gs65c3fy	422	48	coronavirus	coronavirus	NN
cord-312955-gs65c3fy	422	49	infection	infection	NN
cord-312955-gs65c3fy	422	50	in	in	IN
cord-312955-gs65c3fy	422	51	volunteers	volunteer	NNS
cord-312955-gs65c3fy	422	52	Interferon	Interferon	NNP
cord-312955-gs65c3fy	422	53	alfacon-1	alfacon-1	NNP
cord-312955-gs65c3fy	422	54	plus	plus	CC
cord-312955-gs65c3fy	422	55	corticosteroids	corticosteroid	NNS
cord-312955-gs65c3fy	422	56	in	in	IN
cord-312955-gs65c3fy	422	57	severe	severe	JJ
cord-312955-gs65c3fy	422	58	acute	acute	JJ
cord-312955-gs65c3fy	422	59	respiratory	respiratory	JJ
cord-312955-gs65c3fy	422	60	syndrome	syndrome	NN
cord-312955-gs65c3fy	422	61	:	:	:
cord-312955-gs65c3fy	422	62	a	a	DT
cord-312955-gs65c3fy	422	63	preliminary	preliminary	JJ
cord-312955-gs65c3fy	422	64	study	study	NN
cord-312955-gs65c3fy	422	65	Generation	generation	NN
cord-312955-gs65c3fy	422	66	of	of	IN
cord-312955-gs65c3fy	422	67	a	a	DT
cord-312955-gs65c3fy	422	68	Broadly	Broadly	NNP
cord-312955-gs65c3fy	422	69	Useful	Useful	NNP
cord-312955-gs65c3fy	422	70	Model	Model	NNP
cord-312955-gs65c3fy	422	71	for	for	IN
cord-312955-gs65c3fy	422	72	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	422	73	Pathogenesis	Pathogenesis	NNP
cord-312955-gs65c3fy	422	74	,	,	,
cord-312955-gs65c3fy	422	75	Vaccination	Vaccination	NNP
cord-312955-gs65c3fy	422	76	,	,	,
cord-312955-gs65c3fy	422	77	and	and	CC
cord-312955-gs65c3fy	422	78	Treatment	Treatment	NNP
cord-312955-gs65c3fy	422	79	An	an	DT
cord-312955-gs65c3fy	422	80	experimental	experimental	JJ
cord-312955-gs65c3fy	422	81	trial	trial	NN
cord-312955-gs65c3fy	422	82	of	of	IN
cord-312955-gs65c3fy	422	83	recombinant	recombinant	JJ
cord-312955-gs65c3fy	422	84	human	human	JJ
cord-312955-gs65c3fy	422	85	interferon	interferon	NN
cord-312955-gs65c3fy	422	86	alpha	alpha	NN
cord-312955-gs65c3fy	422	87	nasal	nasal	NN
cord-312955-gs65c3fy	422	88	drops	drop	NNS
cord-312955-gs65c3fy	422	89	to	to	TO
cord-312955-gs65c3fy	422	90	prevent	prevent	VB
cord-312955-gs65c3fy	422	91	coronavirus	coronavirus	NN
cord-312955-gs65c3fy	422	92	disease	disease	NN
cord-312955-gs65c3fy	422	93	2019	2019	CD
cord-312955-gs65c3fy	422	94	in	in	IN
cord-312955-gs65c3fy	422	95	medical	medical	JJ
cord-312955-gs65c3fy	422	96	staff	staff	NN
cord-312955-gs65c3fy	422	97	in	in	IN
cord-312955-gs65c3fy	422	98	an	an	DT
cord-312955-gs65c3fy	422	99	epidemic	epidemic	NN
cord-312955-gs65c3fy	422	100	area	area	NN
cord-312955-gs65c3fy	423	1	Triple	triple	JJ
cord-312955-gs65c3fy	423	2	combination	combination	NN
cord-312955-gs65c3fy	423	3	of	of	IN
cord-312955-gs65c3fy	423	4	interferon	interferon	NN
cord-312955-gs65c3fy	423	5	beta-1b	beta-1b	NNP
cord-312955-gs65c3fy	423	6	,	,	,
cord-312955-gs65c3fy	423	7	lopinavir	lopinavir	NNS
cord-312955-gs65c3fy	423	8	-	-	HYPH
cord-312955-gs65c3fy	423	9	ritonavir	ritonavir	NNS
cord-312955-gs65c3fy	423	10	,	,	,
cord-312955-gs65c3fy	423	11	and	and	CC
cord-312955-gs65c3fy	423	12	ribavirin	ribavirin	NN
cord-312955-gs65c3fy	423	13	in	in	IN
cord-312955-gs65c3fy	423	14	the	the	DT
cord-312955-gs65c3fy	423	15	treatment	treatment	NN
cord-312955-gs65c3fy	423	16	of	of	IN
cord-312955-gs65c3fy	423	17	patients	patient	NNS
cord-312955-gs65c3fy	423	18	admitted	admit	VBN
cord-312955-gs65c3fy	423	19	to	to	IN
cord-312955-gs65c3fy	423	20	hospital	hospital	NN
cord-312955-gs65c3fy	423	21	with	with	IN
cord-312955-gs65c3fy	423	22	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	423	23	:	:	:
cord-312955-gs65c3fy	423	24	an	an	DT
cord-312955-gs65c3fy	423	25	open	open	JJ
cord-312955-gs65c3fy	423	26	-	-	HYPH
cord-312955-gs65c3fy	423	27	label	label	NN
cord-312955-gs65c3fy	423	28	,	,	,
cord-312955-gs65c3fy	423	29	randomised	randomised	JJ
cord-312955-gs65c3fy	423	30	,	,	,
cord-312955-gs65c3fy	423	31	phase	phase	NN
cord-312955-gs65c3fy	423	32	2	2	CD
cord-312955-gs65c3fy	423	33	trial	trial	NN
cord-312955-gs65c3fy	423	34	Interferon	Interferon	NNP
cord-312955-gs65c3fy	423	35	-	-	HYPH
cord-312955-gs65c3fy	423	36	a2b	a2b	NNP
cord-312955-gs65c3fy	423	37	Treatment	Treatment	NNP
cord-312955-gs65c3fy	423	38	for	for	IN
cord-312955-gs65c3fy	423	39	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	423	40	A	A	NNP
cord-312955-gs65c3fy	423	41	Randomized	Randomized	NNP
cord-312955-gs65c3fy	423	42	Clinical	Clinical	NNP
cord-312955-gs65c3fy	423	43	Trial	Trial	NNP
cord-312955-gs65c3fy	423	44	of	of	IN
cord-312955-gs65c3fy	423	45	the	the	DT
cord-312955-gs65c3fy	423	46	Efficacy	Efficacy	NNP
cord-312955-gs65c3fy	423	47	and	and	CC
cord-312955-gs65c3fy	423	48	Safety	Safety	NNP
cord-312955-gs65c3fy	423	49	of	of	IN
cord-312955-gs65c3fy	423	50	Interferon	Interferon	NNP
cord-312955-gs65c3fy	423	51	OE≤-1a	OE≤-1a	NNP
cord-312955-gs65c3fy	423	52	in	in	IN
cord-312955-gs65c3fy	423	53	Treatment	Treatment	NNP
cord-312955-gs65c3fy	423	54	of	of	IN
cord-312955-gs65c3fy	423	55	Severe	Severe	NNP
cord-312955-gs65c3fy	423	56	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	423	57	Retrospective	Retrospective	NNP
cord-312955-gs65c3fy	423	58	Multicenter	Multicenter	NNP
cord-312955-gs65c3fy	423	59	Cohort	Cohort	NNP
cord-312955-gs65c3fy	423	60	Study	Study	NNP
cord-312955-gs65c3fy	424	1	Shows	show	NNS
cord-312955-gs65c3fy	425	1	Early	early	JJ
cord-312955-gs65c3fy	425	2	Interferon	Interferon	NNP
cord-312955-gs65c3fy	425	3	Therapy	Therapy	NNP
cord-312955-gs65c3fy	425	4	Is	be	VBZ
cord-312955-gs65c3fy	425	5	Associated	associate	VBN
cord-312955-gs65c3fy	425	6	with	with	IN
cord-312955-gs65c3fy	425	7	Favorable	favorable	JJ
cord-312955-gs65c3fy	425	8	Clinical	Clinical	NNP
cord-312955-gs65c3fy	425	9	Responses	Responses	NNPS
cord-312955-gs65c3fy	425	10	in	in	IN
cord-312955-gs65c3fy	425	11	COVID-19	COVID-19	NNP
cord-312955-gs65c3fy	425	12	Patients	patient	NNS
cord-312955-gs65c3fy	426	1	The	the	DT
cord-312955-gs65c3fy	426	2	mechanism	mechanism	NN
cord-312955-gs65c3fy	426	3	of	of	IN
cord-312955-gs65c3fy	426	4	action	action	NN
cord-312955-gs65c3fy	426	5	of	of	IN
cord-312955-gs65c3fy	426	6	interferon	interferon	NN
cord-312955-gs65c3fy	426	7	-	-	HYPH
cord-312955-gs65c3fy	426	8	b	b	NN
cord-312955-gs65c3fy	426	9	in	in	IN
cord-312955-gs65c3fy	426	10	relapsing	relapse	VBG
cord-312955-gs65c3fy	426	11	multiple	multiple	JJ
cord-312955-gs65c3fy	426	12	sclerosis	sclerosis	NN
cord-312955-gs65c3fy	426	13	Pharmacokinetics	pharmacokinetic	NNS
cord-312955-gs65c3fy	426	14	of	of	IN
cord-312955-gs65c3fy	426	15	alphaIFN-2b	alphaIFN-2b	NNP
cord-312955-gs65c3fy	426	16	in	in	IN
cord-312955-gs65c3fy	426	17	chronic	chronic	JJ
cord-312955-gs65c3fy	426	18	hepatitis	hepatitis	NN
cord-312955-gs65c3fy	426	19	C	c	NN
cord-312955-gs65c3fy	426	20	virus	virus	NN
cord-312955-gs65c3fy	426	21	patients	patient	NNS
cord-312955-gs65c3fy	426	22	undergoing	undergo	VBG
cord-312955-gs65c3fy	426	23	chronic	chronic	JJ
cord-312955-gs65c3fy	426	24	hemodialysis	hemodialysis	NN
cord-312955-gs65c3fy	426	25	or	or	CC
cord-312955-gs65c3fy	426	26	with	with	IN
cord-312955-gs65c3fy	426	27	normal	normal	JJ
cord-312955-gs65c3fy	426	28	renal	renal	JJ
cord-312955-gs65c3fy	426	29	function	function	NN
cord-312955-gs65c3fy	426	30	:	:	:
cord-312955-gs65c3fy	426	31	clinical	clinical	JJ
cord-312955-gs65c3fy	426	32	implications	implication	NNS
cord-312955-gs65c3fy	427	1	Use	Use	NNP
cord-312955-gs65c3fy	427	2	of	of	IN
cord-312955-gs65c3fy	427	3	peginterferon	peginterferon	NNP
cord-312955-gs65c3fy	427	4	alfa-2a	alfa-2a	NNP
cord-312955-gs65c3fy	427	5	(	(	-LRB-
cord-312955-gs65c3fy	427	6	40	40	CD
cord-312955-gs65c3fy	427	7	KD	KD	NNP
cord-312955-gs65c3fy	427	8	)	)	-RRB-
cord-312955-gs65c3fy	427	9	(	(	-LRB-
cord-312955-gs65c3fy	427	10	Pegasys	Pegasys	NNP
cord-312955-gs65c3fy	427	11	®	®	.
cord-312955-gs65c3fy	427	12	)	)	-RRB-
cord-312955-gs65c3fy	427	13	for	for	IN
cord-312955-gs65c3fy	427	14	the	the	DT
cord-312955-gs65c3fy	427	15	treatment	treatment	NN
cord-312955-gs65c3fy	427	16	of	of	IN
cord-312955-gs65c3fy	427	17	hepatitis	hepatitis	NN
cord-312955-gs65c3fy	427	18	C	C	NNP
cord-312955-gs65c3fy	427	19	Biological	Biological	NNP
cord-312955-gs65c3fy	427	20	properties	property	NNS
cord-312955-gs65c3fy	427	21	of	of	IN
cord-312955-gs65c3fy	427	22	recombinant	recombinant	JJ
cord-312955-gs65c3fy	427	23	alpha	alpha	NN
cord-312955-gs65c3fy	427	24	-	-	HYPH
cord-312955-gs65c3fy	427	25	interferons	interferon	NNS
cord-312955-gs65c3fy	427	26	:	:	:
cord-312955-gs65c3fy	428	1	40th	40th	JJ
cord-312955-gs65c3fy	428	2	anniversary	anniversary	NN
cord-312955-gs65c3fy	428	3	of	of	IN
cord-312955-gs65c3fy	428	4	the	the	DT
cord-312955-gs65c3fy	428	5	discovery	discovery	NN
cord-312955-gs65c3fy	428	6	of	of	IN
cord-312955-gs65c3fy	428	7	interferons	interferon	NNS
cord-312955-gs65c3fy	428	8	Bridging	bridge	VBG
cord-312955-gs65c3fy	428	9	the	the	DT
cord-312955-gs65c3fy	428	10	species	specie	NNS
cord-312955-gs65c3fy	428	11	divide	divide	VBP
cord-312955-gs65c3fy	428	12	:	:	:
cord-312955-gs65c3fy	428	13	transgenic	transgenic	JJ
cord-312955-gs65c3fy	428	14	mice	mouse	NNS
cord-312955-gs65c3fy	428	15	humanized	humanize	VBN
cord-312955-gs65c3fy	428	16	for	for	IN
cord-312955-gs65c3fy	428	17	type	type	NN
cord-312955-gs65c3fy	428	18	-	-	:
cord-312955-gs65c3fy	428	19	I	i	NN
cord-312955-gs65c3fy	429	1	interferon	interferon	NNP
cord-312955-gs65c3fy	429	2	response	response	NN
cord-312955-gs65c3fy	430	1	Type	type	NN
cord-312955-gs65c3fy	430	2	I	i	NN
cord-312955-gs65c3fy	430	3	and	and	CC
cord-312955-gs65c3fy	430	4	III	iii	CD
cord-312955-gs65c3fy	430	5	interferons	interferon	NNS
cord-312955-gs65c3fy	430	6	disrupt	disrupt	VBP
cord-312955-gs65c3fy	430	7	lung	lung	NN
cord-312955-gs65c3fy	430	8	epithelial	epithelial	JJ
cord-312955-gs65c3fy	430	9	repair	repair	NN
cord-312955-gs65c3fy	430	10	during	during	IN
cord-312955-gs65c3fy	430	11	recovery	recovery	NN
cord-312955-gs65c3fy	430	12	from	from	IN
cord-312955-gs65c3fy	430	13	viral	viral	JJ
cord-312955-gs65c3fy	430	14	infection	infection	NN
cord-312955-gs65c3fy	431	1	The	the	DT
cord-312955-gs65c3fy	431	2	author	author	NN
cord-312955-gs65c3fy	431	3	declares	declare	VBZ
cord-312955-gs65c3fy	431	4	that	that	IN
cord-312955-gs65c3fy	431	5	the	the	DT
cord-312955-gs65c3fy	431	6	research	research	NN
cord-312955-gs65c3fy	431	7	was	be	VBD
cord-312955-gs65c3fy	431	8	conducted	conduct	VBN
cord-312955-gs65c3fy	431	9	in	in	IN
cord-312955-gs65c3fy	431	10	the	the	DT
cord-312955-gs65c3fy	431	11	absence	absence	NN
cord-312955-gs65c3fy	431	12	of	of	IN
cord-312955-gs65c3fy	431	13	any	any	DT
cord-312955-gs65c3fy	431	14	commercial	commercial	JJ
cord-312955-gs65c3fy	431	15	or	or	CC
cord-312955-gs65c3fy	431	16	financial	financial	JJ
cord-312955-gs65c3fy	431	17	relationships	relationship	NNS
cord-312955-gs65c3fy	431	18	that	that	WDT
cord-312955-gs65c3fy	431	19	could	could	MD
cord-312955-gs65c3fy	431	20	be	be	VB
cord-312955-gs65c3fy	431	21	construed	construe	VBN
cord-312955-gs65c3fy	431	22	as	as	IN
cord-312955-gs65c3fy	431	23	a	a	DT
cord-312955-gs65c3fy	431	24	potential	potential	JJ
cord-312955-gs65c3fy	431	25	conflict	conflict	NN
cord-312955-gs65c3fy	431	26	of	of	IN
cord-312955-gs65c3fy	431	27	interest	interest	NN
cord-312955-gs65c3fy	431	28	.	.	.
cord-312955-gs65c3fy	432	1	Copyright	copyright	NN
cord-312955-gs65c3fy	432	2	©	©	NN
cord-312955-gs65c3fy	432	3	2020	2020	CD
cord-312955-gs65c3fy	432	4	Schreiber	Schreiber	NNP
cord-312955-gs65c3fy	432	5	.	.	.
cord-312955-gs65c3fy	433	1	This	this	DT
cord-312955-gs65c3fy	433	2	is	be	VBZ
cord-312955-gs65c3fy	433	3	an	an	DT
cord-312955-gs65c3fy	433	4	open	open	JJ
cord-312955-gs65c3fy	433	5	-	-	HYPH
cord-312955-gs65c3fy	433	6	access	access	NN
cord-312955-gs65c3fy	433	7	article	article	NN
cord-312955-gs65c3fy	433	8	distributed	distribute	VBN
cord-312955-gs65c3fy	433	9	under	under	IN
cord-312955-gs65c3fy	433	10	the	the	DT
cord-312955-gs65c3fy	433	11	terms	term	NNS
cord-312955-gs65c3fy	433	12	of	of	IN
cord-312955-gs65c3fy	433	13	the	the	DT
cord-312955-gs65c3fy	433	14	Creative	Creative	NNP
cord-312955-gs65c3fy	433	15	Commons	Commons	NNP
cord-312955-gs65c3fy	433	16	Attribution	Attribution	NNP
cord-312955-gs65c3fy	433	17	License	License	NNP
cord-312955-gs65c3fy	433	18	(	(	-LRB-
cord-312955-gs65c3fy	433	19	CC	CC	NNP
cord-312955-gs65c3fy	433	20	BY	BY	NNP
cord-312955-gs65c3fy	433	21	)	)	-RRB-
cord-312955-gs65c3fy	433	22	.	.	.
cord-312955-gs65c3fy	434	1	The	the	DT
cord-312955-gs65c3fy	434	2	use	use	NN
cord-312955-gs65c3fy	434	3	,	,	,
cord-312955-gs65c3fy	434	4	distribution	distribution	NN
cord-312955-gs65c3fy	434	5	or	or	CC
cord-312955-gs65c3fy	434	6	reproduction	reproduction	NN
cord-312955-gs65c3fy	434	7	in	in	IN
cord-312955-gs65c3fy	434	8	other	other	JJ
cord-312955-gs65c3fy	434	9	forums	forum	NNS
cord-312955-gs65c3fy	434	10	is	be	VBZ
cord-312955-gs65c3fy	434	11	permitted	permit	VBN
cord-312955-gs65c3fy	434	12	,	,	,
cord-312955-gs65c3fy	434	13	provided	provide	VBD
cord-312955-gs65c3fy	434	14	the	the	DT
cord-312955-gs65c3fy	434	15	original	original	JJ
cord-312955-gs65c3fy	434	16	author(s	author(s	NNP
cord-312955-gs65c3fy	434	17	)	)	-RRB-
cord-312955-gs65c3fy	434	18	and	and	CC
cord-312955-gs65c3fy	434	19	the	the	DT
cord-312955-gs65c3fy	434	20	copyright	copyright	NN
cord-312955-gs65c3fy	434	21	owner(s	owner(s	NNP
cord-312955-gs65c3fy	434	22	)	)	-RRB-
cord-312955-gs65c3fy	434	23	are	be	VBP
cord-312955-gs65c3fy	434	24	credited	credit	VBN
cord-312955-gs65c3fy	434	25	and	and	CC
cord-312955-gs65c3fy	434	26	that	that	IN
cord-312955-gs65c3fy	434	27	the	the	DT
cord-312955-gs65c3fy	434	28	original	original	JJ
cord-312955-gs65c3fy	434	29	publication	publication	NN
cord-312955-gs65c3fy	434	30	in	in	IN
cord-312955-gs65c3fy	434	31	this	this	DT
cord-312955-gs65c3fy	434	32	journal	journal	NN
cord-312955-gs65c3fy	434	33	is	be	VBZ
cord-312955-gs65c3fy	434	34	cited	cite	VBN
cord-312955-gs65c3fy	434	35	,	,	,
cord-312955-gs65c3fy	434	36	in	in	IN
cord-312955-gs65c3fy	434	37	accordance	accordance	NN
cord-312955-gs65c3fy	434	38	with	with	IN
cord-312955-gs65c3fy	434	39	accepted	accepted	JJ
cord-312955-gs65c3fy	434	40	academic	academic	JJ
cord-312955-gs65c3fy	434	41	practice	practice	NN
cord-312955-gs65c3fy	434	42	.	.	.
cord-312955-gs65c3fy	435	1	No	no	DT
cord-312955-gs65c3fy	435	2	use	use	NN
cord-312955-gs65c3fy	435	3	,	,	,
cord-312955-gs65c3fy	435	4	distribution	distribution	NN
cord-312955-gs65c3fy	435	5	or	or	CC
cord-312955-gs65c3fy	435	6	reproduction	reproduction	NN
cord-312955-gs65c3fy	435	7	is	be	VBZ
cord-312955-gs65c3fy	435	8	permitted	permit	VBN
cord-312955-gs65c3fy	435	9	which	which	WDT
cord-312955-gs65c3fy	435	10	does	do	VBZ
cord-312955-gs65c3fy	435	11	not	not	RB
cord-312955-gs65c3fy	435	12	comply	comply	VB
cord-312955-gs65c3fy	435	13	with	with	IN
cord-312955-gs65c3fy	435	14	these	these	DT
cord-312955-gs65c3fy	435	15	terms	term	NNS
cord-312955-gs65c3fy	435	16	.	.	.