id sid tid token lemma pos cord-001273-plz1ja2e 1 1 key key JJ cord-001273-plz1ja2e 1 2 : : : cord-001273-plz1ja2e 1 3 cord-001273-plz1ja2e cord-001273-plz1ja2e NNP cord-001273-plz1ja2e 2 1 authors author NNS cord-001273-plz1ja2e 2 2 : : : cord-001273-plz1ja2e 2 3 Dussurget Dussurget NNP cord-001273-plz1ja2e 2 4 , , , cord-001273-plz1ja2e 2 5 Olivier Olivier NNP cord-001273-plz1ja2e 2 6 ; ; : cord-001273-plz1ja2e 2 7 Bierne Bierne NNP cord-001273-plz1ja2e 2 8 , , , cord-001273-plz1ja2e 2 9 Hélène Hélène NNP cord-001273-plz1ja2e 2 10 ; ; : cord-001273-plz1ja2e 2 11 Cossart Cossart NNP cord-001273-plz1ja2e 2 12 , , , cord-001273-plz1ja2e 3 1 Pascale Pascale NNP cord-001273-plz1ja2e 3 2 title title NN cord-001273-plz1ja2e 3 3 : : : cord-001273-plz1ja2e 3 4 The the DT cord-001273-plz1ja2e 3 5 bacterial bacterial JJ cord-001273-plz1ja2e 3 6 pathogen pathogen NN cord-001273-plz1ja2e 3 7 Listeria Listeria NNP cord-001273-plz1ja2e 3 8 monocytogenes monocytogene NNS cord-001273-plz1ja2e 3 9 and and CC cord-001273-plz1ja2e 3 10 the the DT cord-001273-plz1ja2e 3 11 interferon interferon NN cord-001273-plz1ja2e 3 12 family family NN cord-001273-plz1ja2e 3 13 : : : cord-001273-plz1ja2e 3 14 type type NN cord-001273-plz1ja2e 3 15 I I NNP cord-001273-plz1ja2e 3 16 , , , cord-001273-plz1ja2e 3 17 type type NN cord-001273-plz1ja2e 3 18 II ii NN cord-001273-plz1ja2e 3 19 and and CC cord-001273-plz1ja2e 3 20 type type NN cord-001273-plz1ja2e 3 21 III iii CD cord-001273-plz1ja2e 3 22 interferons interferon NNS cord-001273-plz1ja2e 3 23 date date NN cord-001273-plz1ja2e 3 24 : : : cord-001273-plz1ja2e 3 25 2014 2014 CD cord-001273-plz1ja2e 3 26 - - HYPH cord-001273-plz1ja2e 3 27 04 04 CD cord-001273-plz1ja2e 3 28 - - HYPH cord-001273-plz1ja2e 3 29 28 28 CD cord-001273-plz1ja2e 3 30 journal journal NN cord-001273-plz1ja2e 3 31 : : : cord-001273-plz1ja2e 3 32 Front front JJ cord-001273-plz1ja2e 3 33 Cell cell NN cord-001273-plz1ja2e 3 34 Infect infect VBP cord-001273-plz1ja2e 3 35 Microbiol Microbiol NNP cord-001273-plz1ja2e 3 36 DOI doi NN cord-001273-plz1ja2e 3 37 : : : cord-001273-plz1ja2e 3 38 10.3389 10.3389 CD cord-001273-plz1ja2e 3 39 / / SYM cord-001273-plz1ja2e 3 40 fcimb.2014.00050 fcimb.2014.00050 VBP cord-001273-plz1ja2e 3 41 sha sha NNP cord-001273-plz1ja2e 3 42 : : : cord-001273-plz1ja2e 3 43 6ad3708c2049874524e4242c18e8fb41c673ccde 6ad3708c2049874524e4242c18e8fb41c673ccde CD cord-001273-plz1ja2e 3 44 doc_id doc_id CD cord-001273-plz1ja2e 3 45 : : : cord-001273-plz1ja2e 3 46 1273 1273 CD cord-001273-plz1ja2e 3 47 cord_uid cord_uid NNS cord-001273-plz1ja2e 3 48 : : : cord-001273-plz1ja2e 3 49 plz1ja2e plz1ja2e CD cord-001273-plz1ja2e 3 50 Interferons interferon NNS cord-001273-plz1ja2e 3 51 ( ( -LRB- cord-001273-plz1ja2e 3 52 IFNs ifn NNS cord-001273-plz1ja2e 3 53 ) ) -RRB- cord-001273-plz1ja2e 3 54 are be VBP cord-001273-plz1ja2e 3 55 secreted secrete VBN cord-001273-plz1ja2e 3 56 proteins protein NNS cord-001273-plz1ja2e 3 57 of of IN cord-001273-plz1ja2e 3 58 the the DT cord-001273-plz1ja2e 3 59 cytokine cytokine NN cord-001273-plz1ja2e 3 60 family family NN cord-001273-plz1ja2e 3 61 that that WDT cord-001273-plz1ja2e 3 62 regulate regulate VBP cord-001273-plz1ja2e 3 63 innate innate JJ cord-001273-plz1ja2e 3 64 and and CC cord-001273-plz1ja2e 3 65 adaptive adaptive JJ cord-001273-plz1ja2e 3 66 immune immune JJ cord-001273-plz1ja2e 3 67 responses response NNS cord-001273-plz1ja2e 3 68 to to IN cord-001273-plz1ja2e 3 69 infection infection NN cord-001273-plz1ja2e 3 70 . . . cord-001273-plz1ja2e 4 1 Although although IN cord-001273-plz1ja2e 4 2 the the DT cord-001273-plz1ja2e 4 3 importance importance NN cord-001273-plz1ja2e 4 4 of of IN cord-001273-plz1ja2e 4 5 IFNs ifn NNS cord-001273-plz1ja2e 4 6 in in IN cord-001273-plz1ja2e 4 7 the the DT cord-001273-plz1ja2e 4 8 antiviral antiviral JJ cord-001273-plz1ja2e 4 9 response response NN cord-001273-plz1ja2e 4 10 has have VBZ cord-001273-plz1ja2e 4 11 long long RB cord-001273-plz1ja2e 4 12 been be VBN cord-001273-plz1ja2e 4 13 appreciated appreciate VBN cord-001273-plz1ja2e 4 14 , , , cord-001273-plz1ja2e 4 15 their -PRON- PRP$ cord-001273-plz1ja2e 4 16 role role NN cord-001273-plz1ja2e 4 17 in in IN cord-001273-plz1ja2e 4 18 bacterial bacterial JJ cord-001273-plz1ja2e 4 19 infections infection NNS cord-001273-plz1ja2e 4 20 is be VBZ cord-001273-plz1ja2e 4 21 more more RBR cord-001273-plz1ja2e 4 22 complex complex JJ cord-001273-plz1ja2e 4 23 and and CC cord-001273-plz1ja2e 4 24 is be VBZ cord-001273-plz1ja2e 4 25 currently currently RB cord-001273-plz1ja2e 4 26 a a DT cord-001273-plz1ja2e 4 27 major major JJ cord-001273-plz1ja2e 4 28 focus focus NN cord-001273-plz1ja2e 4 29 of of IN cord-001273-plz1ja2e 4 30 investigation investigation NN cord-001273-plz1ja2e 4 31 . . . cord-001273-plz1ja2e 5 1 This this DT cord-001273-plz1ja2e 5 2 review review NN cord-001273-plz1ja2e 5 3 summarizes summarize VBZ cord-001273-plz1ja2e 5 4 our -PRON- PRP$ cord-001273-plz1ja2e 5 5 current current JJ cord-001273-plz1ja2e 5 6 knowledge knowledge NN cord-001273-plz1ja2e 5 7 of of IN cord-001273-plz1ja2e 5 8 the the DT cord-001273-plz1ja2e 5 9 role role NN cord-001273-plz1ja2e 5 10 of of IN cord-001273-plz1ja2e 5 11 these these DT cord-001273-plz1ja2e 5 12 cytokines cytokine NNS cord-001273-plz1ja2e 5 13 in in IN cord-001273-plz1ja2e 5 14 host host NN cord-001273-plz1ja2e 5 15 defense defense NN cord-001273-plz1ja2e 5 16 against against IN cord-001273-plz1ja2e 5 17 the the DT cord-001273-plz1ja2e 5 18 bacterial bacterial JJ cord-001273-plz1ja2e 5 19 pathogen pathogen NN cord-001273-plz1ja2e 5 20 Listeria Listeria NNP cord-001273-plz1ja2e 5 21 monocytogenes monocytogene NNS cord-001273-plz1ja2e 5 22 and and CC cord-001273-plz1ja2e 5 23 highlights highlight VBZ cord-001273-plz1ja2e 5 24 recent recent JJ cord-001273-plz1ja2e 5 25 discoveries discovery NNS cord-001273-plz1ja2e 5 26 on on IN cord-001273-plz1ja2e 5 27 the the DT cord-001273-plz1ja2e 5 28 molecular molecular JJ cord-001273-plz1ja2e 5 29 mechanisms mechanism NNS cord-001273-plz1ja2e 5 30 evolved evolve VBN cord-001273-plz1ja2e 5 31 by by IN cord-001273-plz1ja2e 5 32 this this DT cord-001273-plz1ja2e 5 33 intracellular intracellular JJ cord-001273-plz1ja2e 5 34 bacterium bacterium NN cord-001273-plz1ja2e 5 35 to to TO cord-001273-plz1ja2e 5 36 subvert subvert VB cord-001273-plz1ja2e 5 37 IFN IFN NNP cord-001273-plz1ja2e 5 38 responses response NNS cord-001273-plz1ja2e 5 39 . . . cord-001273-plz1ja2e 6 1 Listeria Listeria NNP cord-001273-plz1ja2e 6 2 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 6 3 is be VBZ cord-001273-plz1ja2e 6 4 a a DT cord-001273-plz1ja2e 6 5 pathogenic pathogenic JJ cord-001273-plz1ja2e 6 6 Gram gram NN cord-001273-plz1ja2e 6 7 - - HYPH cord-001273-plz1ja2e 6 8 positive positive JJ cord-001273-plz1ja2e 6 9 bacillus bacillus NN cord-001273-plz1ja2e 6 10 responsible responsible JJ cord-001273-plz1ja2e 6 11 for for IN cord-001273-plz1ja2e 6 12 a a DT cord-001273-plz1ja2e 6 13 foodborne foodborne JJ cord-001273-plz1ja2e 6 14 disease disease NN cord-001273-plz1ja2e 6 15 in in IN cord-001273-plz1ja2e 6 16 humans human NNS cord-001273-plz1ja2e 6 17 and and CC cord-001273-plz1ja2e 6 18 animals animal NNS cord-001273-plz1ja2e 6 19 called call VBN cord-001273-plz1ja2e 6 20 listeriosis listeriosis NN cord-001273-plz1ja2e 7 1 ( ( -LRB- cord-001273-plz1ja2e 7 2 Vázquez Vázquez NNP cord-001273-plz1ja2e 7 3 - - HYPH cord-001273-plz1ja2e 7 4 Boland Boland NNP cord-001273-plz1ja2e 7 5 et et NNP cord-001273-plz1ja2e 7 6 al al NNP cord-001273-plz1ja2e 7 7 . . NNP cord-001273-plz1ja2e 7 8 , , , cord-001273-plz1ja2e 7 9 2001 2001 CD cord-001273-plz1ja2e 7 10 ) ) -RRB- cord-001273-plz1ja2e 7 11 . . . cord-001273-plz1ja2e 8 1 This this DT cord-001273-plz1ja2e 8 2 highly highly RB cord-001273-plz1ja2e 8 3 versatile versatile JJ cord-001273-plz1ja2e 8 4 bacterium bacterium NN cord-001273-plz1ja2e 8 5 can can MD cord-001273-plz1ja2e 8 6 be be VB cord-001273-plz1ja2e 8 7 isolated isolate VBN cord-001273-plz1ja2e 8 8 from from IN cord-001273-plz1ja2e 8 9 multiple multiple JJ cord-001273-plz1ja2e 8 10 sources source NNS cord-001273-plz1ja2e 8 11 such such JJ cord-001273-plz1ja2e 8 12 as as IN cord-001273-plz1ja2e 8 13 human human JJ cord-001273-plz1ja2e 8 14 and and CC cord-001273-plz1ja2e 8 15 animal animal NN cord-001273-plz1ja2e 8 16 feces fece NNS cord-001273-plz1ja2e 8 17 , , , cord-001273-plz1ja2e 8 18 soil soil NN cord-001273-plz1ja2e 8 19 , , , cord-001273-plz1ja2e 8 20 water water NN cord-001273-plz1ja2e 8 21 , , , cord-001273-plz1ja2e 8 22 plants plant NNS cord-001273-plz1ja2e 8 23 and and CC cord-001273-plz1ja2e 8 24 food food NN cord-001273-plz1ja2e 8 25 . . . cord-001273-plz1ja2e 9 1 As as IN cord-001273-plz1ja2e 9 2 a a DT cord-001273-plz1ja2e 9 3 common common JJ cord-001273-plz1ja2e 9 4 contaminant contaminant NN cord-001273-plz1ja2e 9 5 of of IN cord-001273-plz1ja2e 9 6 fruits fruit NNS cord-001273-plz1ja2e 9 7 , , , cord-001273-plz1ja2e 9 8 vegetables vegetable NNS cord-001273-plz1ja2e 9 9 , , , cord-001273-plz1ja2e 9 10 seafood seafood NN cord-001273-plz1ja2e 9 11 , , , cord-001273-plz1ja2e 9 12 meat meat NN cord-001273-plz1ja2e 9 13 and and CC cord-001273-plz1ja2e 9 14 cheese cheese NN cord-001273-plz1ja2e 9 15 , , , cord-001273-plz1ja2e 9 16 it -PRON- PRP cord-001273-plz1ja2e 9 17 represents represent VBZ cord-001273-plz1ja2e 9 18 a a DT cord-001273-plz1ja2e 9 19 major major JJ cord-001273-plz1ja2e 9 20 economic economic JJ cord-001273-plz1ja2e 9 21 problem problem NN cord-001273-plz1ja2e 9 22 for for IN cord-001273-plz1ja2e 9 23 the the DT cord-001273-plz1ja2e 9 24 food food NN cord-001273-plz1ja2e 9 25 industry industry NN cord-001273-plz1ja2e 9 26 . . . cord-001273-plz1ja2e 10 1 Infection infection NN cord-001273-plz1ja2e 10 2 usually usually RB cord-001273-plz1ja2e 10 3 originates originate VBZ cord-001273-plz1ja2e 10 4 from from IN cord-001273-plz1ja2e 10 5 ingestion ingestion NN cord-001273-plz1ja2e 10 6 of of IN cord-001273-plz1ja2e 10 7 contaminated contaminate VBN cord-001273-plz1ja2e 10 8 food food NN cord-001273-plz1ja2e 10 9 ( ( -LRB- cord-001273-plz1ja2e 10 10 Schlech Schlech NNP cord-001273-plz1ja2e 10 11 et et NNP cord-001273-plz1ja2e 10 12 al al NNP cord-001273-plz1ja2e 10 13 . . NNP cord-001273-plz1ja2e 10 14 , , , cord-001273-plz1ja2e 10 15 1983 1983 CD cord-001273-plz1ja2e 10 16 ) ) -RRB- cord-001273-plz1ja2e 10 17 and and CC cord-001273-plz1ja2e 10 18 may may MD cord-001273-plz1ja2e 10 19 cause cause VB cord-001273-plz1ja2e 10 20 febrile febrile JJ cord-001273-plz1ja2e 10 21 gastroenteritis gastroenteritis NN cord-001273-plz1ja2e 10 22 in in IN cord-001273-plz1ja2e 10 23 otherwise otherwise RB cord-001273-plz1ja2e 10 24 healthy healthy JJ cord-001273-plz1ja2e 10 25 persons person NNS cord-001273-plz1ja2e 10 26 ( ( -LRB- cord-001273-plz1ja2e 10 27 Ooi Ooi NNP cord-001273-plz1ja2e 10 28 and and CC cord-001273-plz1ja2e 10 29 Lorber Lorber NNP cord-001273-plz1ja2e 10 30 , , , cord-001273-plz1ja2e 10 31 2005 2005 CD cord-001273-plz1ja2e 10 32 ) ) -RRB- cord-001273-plz1ja2e 10 33 . . . cord-001273-plz1ja2e 11 1 In in IN cord-001273-plz1ja2e 11 2 contrast contrast NN cord-001273-plz1ja2e 11 3 , , , cord-001273-plz1ja2e 11 4 in in IN cord-001273-plz1ja2e 11 5 immunocompromised immunocompromised JJ cord-001273-plz1ja2e 11 6 individuals individual NNS cord-001273-plz1ja2e 11 7 it -PRON- PRP cord-001273-plz1ja2e 11 8 leads lead VBZ cord-001273-plz1ja2e 11 9 to to IN cord-001273-plz1ja2e 11 10 a a DT cord-001273-plz1ja2e 11 11 severe severe JJ cord-001273-plz1ja2e 11 12 invasive invasive JJ cord-001273-plz1ja2e 11 13 disease disease NN cord-001273-plz1ja2e 11 14 , , , cord-001273-plz1ja2e 11 15 which which WDT cord-001273-plz1ja2e 11 16 manifests manifest VBZ cord-001273-plz1ja2e 11 17 itself -PRON- PRP cord-001273-plz1ja2e 11 18 as as IN cord-001273-plz1ja2e 11 19 septicemia septicemia NN cord-001273-plz1ja2e 11 20 , , , cord-001273-plz1ja2e 11 21 meningitis meningitis NN cord-001273-plz1ja2e 11 22 and and CC cord-001273-plz1ja2e 11 23 encephalitis encephalitis NN cord-001273-plz1ja2e 11 24 . . . cord-001273-plz1ja2e 12 1 In in IN cord-001273-plz1ja2e 12 2 the the DT cord-001273-plz1ja2e 12 3 specific specific JJ cord-001273-plz1ja2e 12 4 case case NN cord-001273-plz1ja2e 12 5 of of IN cord-001273-plz1ja2e 12 6 pregnant pregnant JJ cord-001273-plz1ja2e 12 7 women woman NNS cord-001273-plz1ja2e 12 8 , , , cord-001273-plz1ja2e 12 9 infection infection NN cord-001273-plz1ja2e 12 10 may may MD cord-001273-plz1ja2e 12 11 cause cause VB cord-001273-plz1ja2e 12 12 fetal fetal JJ cord-001273-plz1ja2e 12 13 loss loss NN cord-001273-plz1ja2e 12 14 or or CC cord-001273-plz1ja2e 12 15 neonatal neonatal JJ cord-001273-plz1ja2e 12 16 bacteremia bacteremia NN cord-001273-plz1ja2e 12 17 and and CC cord-001273-plz1ja2e 12 18 meningitis meningitis NN cord-001273-plz1ja2e 12 19 . . . cord-001273-plz1ja2e 13 1 In in IN cord-001273-plz1ja2e 13 2 the the DT cord-001273-plz1ja2e 13 3 United United NNP cord-001273-plz1ja2e 13 4 States States NNP cord-001273-plz1ja2e 13 5 , , , cord-001273-plz1ja2e 13 6 incidence incidence NN cord-001273-plz1ja2e 13 7 of of IN cord-001273-plz1ja2e 13 8 listeriosis listeriosis NN cord-001273-plz1ja2e 13 9 ranged range VBN cord-001273-plz1ja2e 13 10 from from IN cord-001273-plz1ja2e 13 11 2.5 2.5 CD cord-001273-plz1ja2e 13 12 to to IN cord-001273-plz1ja2e 13 13 3.2 3.2 CD cord-001273-plz1ja2e 13 14 cases case NNS cord-001273-plz1ja2e 13 15 per per IN cord-001273-plz1ja2e 13 16 million million CD cord-001273-plz1ja2e 13 17 population population NN cord-001273-plz1ja2e 13 18 between between IN cord-001273-plz1ja2e 13 19 2004 2004 CD cord-001273-plz1ja2e 13 20 and and CC cord-001273-plz1ja2e 13 21 2009 2009 CD cord-001273-plz1ja2e 13 22 ( ( -LRB- cord-001273-plz1ja2e 13 23 Cartwright Cartwright NNP cord-001273-plz1ja2e 13 24 et et NNP cord-001273-plz1ja2e 13 25 al al NNP cord-001273-plz1ja2e 13 26 . . NNP cord-001273-plz1ja2e 13 27 , , , cord-001273-plz1ja2e 13 28 2013 2013 CD cord-001273-plz1ja2e 13 29 ) ) -RRB- cord-001273-plz1ja2e 13 30 . . . cord-001273-plz1ja2e 14 1 In in IN cord-001273-plz1ja2e 14 2 France France NNP cord-001273-plz1ja2e 14 3 , , , cord-001273-plz1ja2e 14 4 incidence incidence NN cord-001273-plz1ja2e 14 5 was be VBD cord-001273-plz1ja2e 14 6 3.9 3.9 CD cord-001273-plz1ja2e 14 7 per per IN cord-001273-plz1ja2e 14 8 million million CD cord-001273-plz1ja2e 14 9 between between IN cord-001273-plz1ja2e 14 10 2001 2001 CD cord-001273-plz1ja2e 14 11 and and CC cord-001273-plz1ja2e 14 12 2008 2008 CD cord-001273-plz1ja2e 14 13 , , , cord-001273-plz1ja2e 14 14 and and CC cord-001273-plz1ja2e 14 15 increased increase VBN cord-001273-plz1ja2e 14 16 risk risk NN cord-001273-plz1ja2e 14 17 of of IN cord-001273-plz1ja2e 14 18 listeriosis listeriosis NN cord-001273-plz1ja2e 14 19 was be VBD cord-001273-plz1ja2e 14 20 noticed notice VBN cord-001273-plz1ja2e 14 21 in in IN cord-001273-plz1ja2e 14 22 people people NNS cord-001273-plz1ja2e 14 23 with with IN cord-001273-plz1ja2e 14 24 underlying underlie VBG cord-001273-plz1ja2e 14 25 diseases disease NNS cord-001273-plz1ja2e 14 26 , , , cord-001273-plz1ja2e 14 27 such such JJ cord-001273-plz1ja2e 14 28 as as IN cord-001273-plz1ja2e 14 29 chronic chronic JJ cord-001273-plz1ja2e 14 30 lymphocytic lymphocytic JJ cord-001273-plz1ja2e 14 31 leukemia leukemia NN cord-001273-plz1ja2e 15 1 ( ( -LRB- cord-001273-plz1ja2e 15 2 Goulet Goulet NNP cord-001273-plz1ja2e 15 3 et et NNP cord-001273-plz1ja2e 15 4 al al NNP cord-001273-plz1ja2e 15 5 . . NNP cord-001273-plz1ja2e 15 6 , , , cord-001273-plz1ja2e 15 7 2012 2012 CD cord-001273-plz1ja2e 15 8 ) ) -RRB- cord-001273-plz1ja2e 15 9 . . . cord-001273-plz1ja2e 16 1 While while IN cord-001273-plz1ja2e 16 2 relatively relatively RB cord-001273-plz1ja2e 16 3 rare rare JJ cord-001273-plz1ja2e 16 4 , , , cord-001273-plz1ja2e 16 5 listeriosis listeriosis NN cord-001273-plz1ja2e 16 6 is be VBZ cord-001273-plz1ja2e 16 7 among among IN cord-001273-plz1ja2e 16 8 the the DT cord-001273-plz1ja2e 16 9 most most RBS cord-001273-plz1ja2e 16 10 deadly deadly JJ cord-001273-plz1ja2e 16 11 foodborne foodborne JJ cord-001273-plz1ja2e 16 12 diseases disease NNS cord-001273-plz1ja2e 16 13 with with IN cord-001273-plz1ja2e 16 14 mortality mortality NN cord-001273-plz1ja2e 16 15 rates rate NNS cord-001273-plz1ja2e 16 16 reaching reach VBG cord-001273-plz1ja2e 16 17 up up IN cord-001273-plz1ja2e 16 18 to to TO cord-001273-plz1ja2e 16 19 50 50 CD cord-001273-plz1ja2e 16 20 % % NN cord-001273-plz1ja2e 16 21 depending depend VBG cord-001273-plz1ja2e 16 22 on on IN cord-001273-plz1ja2e 16 23 the the DT cord-001273-plz1ja2e 16 24 clinical clinical JJ cord-001273-plz1ja2e 16 25 manifestations manifestation NNS cord-001273-plz1ja2e 16 26 ( ( -LRB- cord-001273-plz1ja2e 16 27 Lorber Lorber NNP cord-001273-plz1ja2e 16 28 , , , cord-001273-plz1ja2e 16 29 1997 1997 CD cord-001273-plz1ja2e 16 30 ) ) -RRB- cord-001273-plz1ja2e 16 31 . . . cord-001273-plz1ja2e 17 1 In in IN cord-001273-plz1ja2e 17 2 addition addition NN cord-001273-plz1ja2e 17 3 to to IN cord-001273-plz1ja2e 17 4 the the DT cord-001273-plz1ja2e 17 5 immunological immunological JJ cord-001273-plz1ja2e 17 6 status status NN cord-001273-plz1ja2e 17 7 of of IN cord-001273-plz1ja2e 17 8 the the DT cord-001273-plz1ja2e 17 9 patient patient NN cord-001273-plz1ja2e 17 10 , , , cord-001273-plz1ja2e 17 11 the the DT cord-001273-plz1ja2e 17 12 clinical clinical JJ cord-001273-plz1ja2e 17 13 outcome outcome NN cord-001273-plz1ja2e 17 14 of of IN cord-001273-plz1ja2e 17 15 the the DT cord-001273-plz1ja2e 17 16 disease disease NN cord-001273-plz1ja2e 17 17 depends depend VBZ cord-001273-plz1ja2e 17 18 on on IN cord-001273-plz1ja2e 17 19 the the DT cord-001273-plz1ja2e 17 20 pathogenic pathogenic JJ cord-001273-plz1ja2e 17 21 potential potential NN cord-001273-plz1ja2e 17 22 of of IN cord-001273-plz1ja2e 17 23 the the DT cord-001273-plz1ja2e 17 24 infecting infect VBG cord-001273-plz1ja2e 17 25 bacteria bacteria NNS cord-001273-plz1ja2e 17 26 . . . cord-001273-plz1ja2e 18 1 L. L. NNP cord-001273-plz1ja2e 18 2 monocytogenes monocytogenes NN cord-001273-plz1ja2e 18 3 strains strain NNS cord-001273-plz1ja2e 18 4 of of IN cord-001273-plz1ja2e 18 5 serovars serovar NNS cord-001273-plz1ja2e 18 6 1/2a 1/2a RB cord-001273-plz1ja2e 18 7 , , , cord-001273-plz1ja2e 18 8 1/2b 1/2b CD cord-001273-plz1ja2e 18 9 , , , cord-001273-plz1ja2e 18 10 and and CC cord-001273-plz1ja2e 18 11 4b 4b NNS cord-001273-plz1ja2e 18 12 account account VBP cord-001273-plz1ja2e 18 13 for for IN cord-001273-plz1ja2e 18 14 95 95 CD cord-001273-plz1ja2e 18 15 % % NN cord-001273-plz1ja2e 18 16 of of IN cord-001273-plz1ja2e 18 17 human human JJ cord-001273-plz1ja2e 18 18 cases case NNS cord-001273-plz1ja2e 18 19 and and CC cord-001273-plz1ja2e 18 20 serovar serovar NNP cord-001273-plz1ja2e 18 21 4b 4b NNS cord-001273-plz1ja2e 18 22 alone alone JJ cord-001273-plz1ja2e 19 1 is be VBZ cord-001273-plz1ja2e 19 2 associated associate VBN cord-001273-plz1ja2e 19 3 to to IN cord-001273-plz1ja2e 19 4 most most JJS cord-001273-plz1ja2e 19 5 outbreaks outbreak NNS cord-001273-plz1ja2e 19 6 ( ( -LRB- cord-001273-plz1ja2e 19 7 Swaminathan Swaminathan NNP cord-001273-plz1ja2e 19 8 and and CC cord-001273-plz1ja2e 19 9 Gernersmidt Gernersmidt NNP cord-001273-plz1ja2e 19 10 , , , cord-001273-plz1ja2e 19 11 2007 2007 CD cord-001273-plz1ja2e 19 12 ) ) -RRB- cord-001273-plz1ja2e 19 13 . . . cord-001273-plz1ja2e 20 1 The the DT cord-001273-plz1ja2e 20 2 capacity capacity NN cord-001273-plz1ja2e 20 3 of of IN cord-001273-plz1ja2e 20 4 L. L. NNP cord-001273-plz1ja2e 20 5 monocytogenes monocytogene NNS cord-001273-plz1ja2e 20 6 to to TO cord-001273-plz1ja2e 20 7 survive survive VB cord-001273-plz1ja2e 20 8 and and CC cord-001273-plz1ja2e 20 9 multiply multiply VB cord-001273-plz1ja2e 20 10 within within IN cord-001273-plz1ja2e 20 11 the the DT cord-001273-plz1ja2e 20 12 gastrointestinal gastrointestinal JJ cord-001273-plz1ja2e 20 13 tract tract NN cord-001273-plz1ja2e 20 14 is be VBZ cord-001273-plz1ja2e 20 15 critical critical JJ cord-001273-plz1ja2e 20 16 for for IN cord-001273-plz1ja2e 20 17 the the DT cord-001273-plz1ja2e 20 18 initial initial JJ cord-001273-plz1ja2e 20 19 infection infection NN cord-001273-plz1ja2e 20 20 , , , cord-001273-plz1ja2e 20 21 persistence persistence NN cord-001273-plz1ja2e 20 22 and and CC cord-001273-plz1ja2e 20 23 transmission transmission NN cord-001273-plz1ja2e 20 24 . . . cord-001273-plz1ja2e 21 1 L. L. NNP cord-001273-plz1ja2e 21 2 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 21 3 is be VBZ cord-001273-plz1ja2e 21 4 well well RB cord-001273-plz1ja2e 21 5 adapted adapt VBN cord-001273-plz1ja2e 21 6 to to IN cord-001273-plz1ja2e 21 7 this this DT cord-001273-plz1ja2e 21 8 environment environment NN cord-001273-plz1ja2e 21 9 and and CC cord-001273-plz1ja2e 21 10 produces produce VBZ cord-001273-plz1ja2e 21 11 multiple multiple JJ cord-001273-plz1ja2e 21 12 factors factor NNS cord-001273-plz1ja2e 21 13 to to TO cord-001273-plz1ja2e 21 14 compete compete VB cord-001273-plz1ja2e 21 15 with with IN cord-001273-plz1ja2e 21 16 microbiota microbiota NN cord-001273-plz1ja2e 21 17 and and CC cord-001273-plz1ja2e 21 18 counteract counteract VB cord-001273-plz1ja2e 21 19 antimicrobial antimicrobial JJ cord-001273-plz1ja2e 21 20 peptides peptide NNS cord-001273-plz1ja2e 21 21 , , , cord-001273-plz1ja2e 21 22 acidity acidity NN cord-001273-plz1ja2e 21 23 , , , cord-001273-plz1ja2e 21 24 hyperosmolarity hyperosmolarity NN cord-001273-plz1ja2e 21 25 , , , cord-001273-plz1ja2e 21 26 hypoxia hypoxia NN cord-001273-plz1ja2e 21 27 , , , cord-001273-plz1ja2e 21 28 bile bile NN cord-001273-plz1ja2e 21 29 and and CC cord-001273-plz1ja2e 21 30 iron iron NN cord-001273-plz1ja2e 21 31 deprivation deprivation NN cord-001273-plz1ja2e 21 32 ( ( -LRB- cord-001273-plz1ja2e 21 33 Gahan Gahan NNP cord-001273-plz1ja2e 21 34 and and CC cord-001273-plz1ja2e 21 35 Hill Hill NNP cord-001273-plz1ja2e 21 36 , , , cord-001273-plz1ja2e 21 37 2005 2005 CD cord-001273-plz1ja2e 21 38 ) ) -RRB- cord-001273-plz1ja2e 21 39 . . . cord-001273-plz1ja2e 22 1 Crossing crossing NN cord-001273-plz1ja2e 22 2 of of IN cord-001273-plz1ja2e 22 3 the the DT cord-001273-plz1ja2e 22 4 intestinal intestinal JJ cord-001273-plz1ja2e 22 5 epithelium epithelium NN cord-001273-plz1ja2e 22 6 is be VBZ cord-001273-plz1ja2e 22 7 thought think VBN cord-001273-plz1ja2e 22 8 to to TO cord-001273-plz1ja2e 22 9 occur occur VB cord-001273-plz1ja2e 22 10 by by IN cord-001273-plz1ja2e 22 11 invasion invasion NN cord-001273-plz1ja2e 22 12 of of IN cord-001273-plz1ja2e 22 13 enterocytes enterocytes NNP cord-001273-plz1ja2e 22 14 , , , cord-001273-plz1ja2e 22 15 in in IN cord-001273-plz1ja2e 22 16 particular particular JJ cord-001273-plz1ja2e 22 17 goblet goblet NN cord-001273-plz1ja2e 22 18 cells cell NNS cord-001273-plz1ja2e 22 19 and and CC cord-001273-plz1ja2e 22 20 M M NNP cord-001273-plz1ja2e 22 21 cells cell NNS cord-001273-plz1ja2e 22 22 of of IN cord-001273-plz1ja2e 22 23 the the DT cord-001273-plz1ja2e 22 24 Peyer Peyer NNP cord-001273-plz1ja2e 22 25 's 's POS cord-001273-plz1ja2e 22 26 patches patch NNS cord-001273-plz1ja2e 22 27 . . . cord-001273-plz1ja2e 23 1 Invasion invasion NN cord-001273-plz1ja2e 23 2 of of IN cord-001273-plz1ja2e 23 3 enterocytes enterocytes NNP cord-001273-plz1ja2e 23 4 requires require VBZ cord-001273-plz1ja2e 23 5 the the DT cord-001273-plz1ja2e 23 6 specific specific JJ cord-001273-plz1ja2e 23 7 interaction interaction NN cord-001273-plz1ja2e 23 8 between between IN cord-001273-plz1ja2e 23 9 the the DT cord-001273-plz1ja2e 23 10 Listeria Listeria NNP cord-001273-plz1ja2e 23 11 surface surface NN cord-001273-plz1ja2e 23 12 protein protein NN cord-001273-plz1ja2e 23 13 InlA InlA NNP cord-001273-plz1ja2e 23 14 and and CC cord-001273-plz1ja2e 23 15 its -PRON- PRP$ cord-001273-plz1ja2e 23 16 cellular cellular JJ cord-001273-plz1ja2e 23 17 receptor receptor NN cord-001273-plz1ja2e 23 18 E e NN cord-001273-plz1ja2e 23 19 - - NN cord-001273-plz1ja2e 23 20 cadherin cadherin JJ cord-001273-plz1ja2e 24 1 ( ( -LRB- cord-001273-plz1ja2e 24 2 Lecuit Lecuit NNP cord-001273-plz1ja2e 24 3 et et NNP cord-001273-plz1ja2e 24 4 al al NNP cord-001273-plz1ja2e 24 5 . . NNP cord-001273-plz1ja2e 24 6 , , , cord-001273-plz1ja2e 24 7 2001 2001 CD cord-001273-plz1ja2e 25 1 ; ; : cord-001273-plz1ja2e 25 2 Disson Disson NNP cord-001273-plz1ja2e 25 3 et et NNP cord-001273-plz1ja2e 25 4 al al NNP cord-001273-plz1ja2e 25 5 . . NNP cord-001273-plz1ja2e 25 6 , , , cord-001273-plz1ja2e 25 7 2008 2008 CD cord-001273-plz1ja2e 25 8 ) ) -RRB- cord-001273-plz1ja2e 25 9 , , , cord-001273-plz1ja2e 25 10 which which WDT cord-001273-plz1ja2e 25 11 can can MD cord-001273-plz1ja2e 25 12 take take VB cord-001273-plz1ja2e 25 13 place place NN cord-001273-plz1ja2e 25 14 at at IN cord-001273-plz1ja2e 25 15 sites site NNS cord-001273-plz1ja2e 25 16 of of IN cord-001273-plz1ja2e 25 17 cell cell NN cord-001273-plz1ja2e 25 18 extrusion extrusion NN cord-001273-plz1ja2e 25 19 at at IN cord-001273-plz1ja2e 25 20 the the DT cord-001273-plz1ja2e 25 21 tip tip NN cord-001273-plz1ja2e 25 22 and and CC cord-001273-plz1ja2e 25 23 other other JJ cord-001273-plz1ja2e 25 24 locations location NNS cord-001273-plz1ja2e 25 25 of of IN cord-001273-plz1ja2e 25 26 intestinal intestinal JJ cord-001273-plz1ja2e 25 27 villi villus NNS cord-001273-plz1ja2e 25 28 ( ( -LRB- cord-001273-plz1ja2e 25 29 Pentecost Pentecost NNP cord-001273-plz1ja2e 25 30 et et NNP cord-001273-plz1ja2e 25 31 al al NNP cord-001273-plz1ja2e 25 32 . . NNP cord-001273-plz1ja2e 25 33 , , , cord-001273-plz1ja2e 25 34 2006 2006 CD cord-001273-plz1ja2e 25 35 ; ; : cord-001273-plz1ja2e 25 36 Nikitas Nikitas NNP cord-001273-plz1ja2e 25 37 et et NNP cord-001273-plz1ja2e 25 38 al al NNP cord-001273-plz1ja2e 25 39 . . NNP cord-001273-plz1ja2e 25 40 , , , cord-001273-plz1ja2e 25 41 2011 2011 CD cord-001273-plz1ja2e 25 42 ) ) -RRB- cord-001273-plz1ja2e 25 43 . . . cord-001273-plz1ja2e 26 1 Indeed indeed RB cord-001273-plz1ja2e 26 2 , , , cord-001273-plz1ja2e 26 3 as as IN cord-001273-plz1ja2e 26 4 recently recently RB cord-001273-plz1ja2e 26 5 shown show VBN cord-001273-plz1ja2e 26 6 , , , cord-001273-plz1ja2e 26 7 upon upon IN cord-001273-plz1ja2e 26 8 interaction interaction NN cord-001273-plz1ja2e 26 9 with with IN cord-001273-plz1ja2e 26 10 E e NN cord-001273-plz1ja2e 26 11 - - NN cord-001273-plz1ja2e 26 12 cadherin cadherin NN cord-001273-plz1ja2e 26 13 , , , cord-001273-plz1ja2e 26 14 Listeria Listeria NNP cord-001273-plz1ja2e 26 15 preferentially preferentially RB cord-001273-plz1ja2e 26 16 crosses cross VBZ cord-001273-plz1ja2e 26 17 the the DT cord-001273-plz1ja2e 26 18 intestinal intestinal JJ cord-001273-plz1ja2e 26 19 barrier barrier NN cord-001273-plz1ja2e 26 20 by by IN cord-001273-plz1ja2e 26 21 transcytosis transcytosis NNP cord-001273-plz1ja2e 26 22 through through IN cord-001273-plz1ja2e 26 23 goblet goblet NN cord-001273-plz1ja2e 26 24 cells cell NNS cord-001273-plz1ja2e 26 25 ( ( -LRB- cord-001273-plz1ja2e 26 26 Nikitas Nikitas NNP cord-001273-plz1ja2e 26 27 et et NNP cord-001273-plz1ja2e 26 28 al al NNP cord-001273-plz1ja2e 26 29 . . NNP cord-001273-plz1ja2e 26 30 , , , cord-001273-plz1ja2e 26 31 2011 2011 CD cord-001273-plz1ja2e 26 32 ) ) -RRB- cord-001273-plz1ja2e 26 33 . . . cord-001273-plz1ja2e 27 1 Entry entry NN cord-001273-plz1ja2e 27 2 through through IN cord-001273-plz1ja2e 27 3 ileal ileal JJ cord-001273-plz1ja2e 27 4 Peyer Peyer NNP cord-001273-plz1ja2e 27 5 's 's POS cord-001273-plz1ja2e 27 6 patches patch NNS cord-001273-plz1ja2e 27 7 via via IN cord-001273-plz1ja2e 28 1 M M NNP cord-001273-plz1ja2e 28 2 cells cell NNS cord-001273-plz1ja2e 28 3 does do VBZ cord-001273-plz1ja2e 28 4 not not RB cord-001273-plz1ja2e 28 5 rely rely VB cord-001273-plz1ja2e 28 6 on on IN cord-001273-plz1ja2e 28 7 InlA. inla. NN cord-001273-plz1ja2e 29 1 It -PRON- PRP cord-001273-plz1ja2e 29 2 has have VBZ cord-001273-plz1ja2e 29 3 been be VBN cord-001273-plz1ja2e 29 4 reported report VBN cord-001273-plz1ja2e 29 5 to to TO cord-001273-plz1ja2e 29 6 require require VB cord-001273-plz1ja2e 29 7 Listeria Listeria NNP cord-001273-plz1ja2e 29 8 invasion invasion NN cord-001273-plz1ja2e 29 9 protein protein NN cord-001273-plz1ja2e 29 10 InlB InlB NNP cord-001273-plz1ja2e 29 11 ( ( -LRB- cord-001273-plz1ja2e 29 12 Chiba Chiba NNP cord-001273-plz1ja2e 29 13 et et NNP cord-001273-plz1ja2e 29 14 al al NNP cord-001273-plz1ja2e 29 15 . . . cord-001273-plz1ja2e 30 1 , , , cord-001273-plz1ja2e 30 2 2011 2011 CD cord-001273-plz1ja2e 30 3 ) ) -RRB- cord-001273-plz1ja2e 30 4 . . . cord-001273-plz1ja2e 31 1 After after IN cord-001273-plz1ja2e 31 2 translocation translocation NN cord-001273-plz1ja2e 31 3 , , , cord-001273-plz1ja2e 31 4 bacteria bacteria NNS cord-001273-plz1ja2e 31 5 reach reach VBP cord-001273-plz1ja2e 31 6 lymph lymph NN cord-001273-plz1ja2e 31 7 nodes node NNS cord-001273-plz1ja2e 31 8 , , , cord-001273-plz1ja2e 31 9 the the DT cord-001273-plz1ja2e 31 10 liver liver NN cord-001273-plz1ja2e 31 11 and and CC cord-001273-plz1ja2e 31 12 spleen spleen NN cord-001273-plz1ja2e 31 13 and and CC cord-001273-plz1ja2e 31 14 finally finally RB cord-001273-plz1ja2e 31 15 secondary secondary JJ cord-001273-plz1ja2e 31 16 target target NN cord-001273-plz1ja2e 31 17 sites site NNS cord-001273-plz1ja2e 31 18 of of IN cord-001273-plz1ja2e 31 19 infection infection NN cord-001273-plz1ja2e 31 20 , , , cord-001273-plz1ja2e 31 21 including include VBG cord-001273-plz1ja2e 31 22 the the DT cord-001273-plz1ja2e 31 23 central central JJ cord-001273-plz1ja2e 31 24 nervous nervous JJ cord-001273-plz1ja2e 31 25 system system NN cord-001273-plz1ja2e 31 26 and and CC cord-001273-plz1ja2e 31 27 the the DT cord-001273-plz1ja2e 31 28 placenta placenta NN cord-001273-plz1ja2e 31 29 . . . cord-001273-plz1ja2e 32 1 A a DT cord-001273-plz1ja2e 32 2 remarkable remarkable JJ cord-001273-plz1ja2e 32 3 feature feature NN cord-001273-plz1ja2e 32 4 of of IN cord-001273-plz1ja2e 32 5 L. L. NNP cord-001273-plz1ja2e 32 6 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 32 7 is be VBZ cord-001273-plz1ja2e 32 8 its -PRON- PRP$ cord-001273-plz1ja2e 32 9 capacity capacity NN cord-001273-plz1ja2e 32 10 to to TO cord-001273-plz1ja2e 32 11 invade invade VB cord-001273-plz1ja2e 32 12 non non JJ cord-001273-plz1ja2e 32 13 - - JJ cord-001273-plz1ja2e 32 14 professional professional JJ cord-001273-plz1ja2e 32 15 phagocytic phagocytic JJ cord-001273-plz1ja2e 32 16 cells cell NNS cord-001273-plz1ja2e 32 17 such such JJ cord-001273-plz1ja2e 32 18 as as IN cord-001273-plz1ja2e 32 19 enterocytes enterocyte NNS cord-001273-plz1ja2e 32 20 , , , cord-001273-plz1ja2e 32 21 hepatocytes hepatocyte NNS cord-001273-plz1ja2e 32 22 and and CC cord-001273-plz1ja2e 32 23 trophoblast trophoblast NN cord-001273-plz1ja2e 32 24 cells cell NNS cord-001273-plz1ja2e 32 25 . . . cord-001273-plz1ja2e 33 1 The the DT cord-001273-plz1ja2e 33 2 exceptional exceptional JJ cord-001273-plz1ja2e 33 3 repertoire repertoire NN cord-001273-plz1ja2e 33 4 of of IN cord-001273-plz1ja2e 33 5 virulence virulence NN cord-001273-plz1ja2e 33 6 factors factor NNS cord-001273-plz1ja2e 33 7 necessary necessary JJ cord-001273-plz1ja2e 33 8 for for IN cord-001273-plz1ja2e 33 9 entry entry NN cord-001273-plz1ja2e 33 10 , , , cord-001273-plz1ja2e 33 11 survival survival NN cord-001273-plz1ja2e 33 12 and and CC cord-001273-plz1ja2e 33 13 multiplication multiplication NN cord-001273-plz1ja2e 33 14 has have VBZ cord-001273-plz1ja2e 33 15 been be VBN cord-001273-plz1ja2e 33 16 extensively extensively RB cord-001273-plz1ja2e 33 17 studied study VBN cord-001273-plz1ja2e 33 18 Cossart Cossart NNP cord-001273-plz1ja2e 33 19 , , , cord-001273-plz1ja2e 33 20 2011 2011 CD cord-001273-plz1ja2e 33 21 ) ) -RRB- cord-001273-plz1ja2e 33 22 . . . cord-001273-plz1ja2e 34 1 Expression expression NN cord-001273-plz1ja2e 34 2 of of IN cord-001273-plz1ja2e 34 3 many many JJ cord-001273-plz1ja2e 34 4 virulence virulence NN cord-001273-plz1ja2e 34 5 genes gene NNS cord-001273-plz1ja2e 34 6 relies rely VBZ cord-001273-plz1ja2e 34 7 on on IN cord-001273-plz1ja2e 34 8 the the DT cord-001273-plz1ja2e 34 9 transcriptional transcriptional JJ cord-001273-plz1ja2e 34 10 activator activator NN cord-001273-plz1ja2e 34 11 PrfA PrfA NNP cord-001273-plz1ja2e 34 12 , , , cord-001273-plz1ja2e 34 13 whose whose WP$ cord-001273-plz1ja2e 34 14 role role NN cord-001273-plz1ja2e 34 15 is be VBZ cord-001273-plz1ja2e 34 16 pivotal pivotal JJ cord-001273-plz1ja2e 34 17 for for IN cord-001273-plz1ja2e 34 18 L. L. NNP cord-001273-plz1ja2e 34 19 monocytogenes monocytogenes NN cord-001273-plz1ja2e 34 20 transition transition NN cord-001273-plz1ja2e 34 21 from from IN cord-001273-plz1ja2e 34 22 saprophytic saprophytic JJ cord-001273-plz1ja2e 34 23 to to IN cord-001273-plz1ja2e 34 24 intracellular intracellular JJ cord-001273-plz1ja2e 34 25 lifestyle lifestyle NN cord-001273-plz1ja2e 35 1 ( ( -LRB- cord-001273-plz1ja2e 35 2 Freitag Freitag NNP cord-001273-plz1ja2e 35 3 et et NNP cord-001273-plz1ja2e 35 4 al al NNP cord-001273-plz1ja2e 35 5 . . NNP cord-001273-plz1ja2e 35 6 , , , cord-001273-plz1ja2e 35 7 2009 2009 CD cord-001273-plz1ja2e 35 8 ; ; : cord-001273-plz1ja2e 35 9 Toledo Toledo NNP cord-001273-plz1ja2e 35 10 - - HYPH cord-001273-plz1ja2e 35 11 Arana Arana NNP cord-001273-plz1ja2e 35 12 et et NNP cord-001273-plz1ja2e 35 13 al al NNP cord-001273-plz1ja2e 35 14 . . NNP cord-001273-plz1ja2e 35 15 , , , cord-001273-plz1ja2e 35 16 2009 2009 CD cord-001273-plz1ja2e 35 17 ) ) -RRB- cord-001273-plz1ja2e 35 18 . . . cord-001273-plz1ja2e 36 1 Elimination elimination NN cord-001273-plz1ja2e 36 2 of of IN cord-001273-plz1ja2e 36 3 L. L. NNP cord-001273-plz1ja2e 36 4 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 36 5 is be VBZ cord-001273-plz1ja2e 36 6 mostly mostly RB cord-001273-plz1ja2e 36 7 based base VBN cord-001273-plz1ja2e 36 8 on on IN cord-001273-plz1ja2e 36 9 the the DT cord-001273-plz1ja2e 36 10 capacity capacity NN cord-001273-plz1ja2e 36 11 of of IN cord-001273-plz1ja2e 36 12 the the DT cord-001273-plz1ja2e 36 13 host host NN cord-001273-plz1ja2e 36 14 to to TO cord-001273-plz1ja2e 36 15 mount mount VB cord-001273-plz1ja2e 36 16 an an DT cord-001273-plz1ja2e 36 17 efficient efficient JJ cord-001273-plz1ja2e 36 18 cellular cellular JJ cord-001273-plz1ja2e 36 19 immune immune JJ cord-001273-plz1ja2e 36 20 response response NN cord-001273-plz1ja2e 36 21 to to IN cord-001273-plz1ja2e 36 22 infection infection NN cord-001273-plz1ja2e 36 23 ( ( -LRB- cord-001273-plz1ja2e 36 24 Mackaness Mackaness NNP cord-001273-plz1ja2e 36 25 , , , cord-001273-plz1ja2e 36 26 1962 1962 CD cord-001273-plz1ja2e 36 27 ; ; : cord-001273-plz1ja2e 36 28 Shi Shi NNP cord-001273-plz1ja2e 36 29 and and CC cord-001273-plz1ja2e 36 30 Pamer Pamer NNP cord-001273-plz1ja2e 36 31 , , , cord-001273-plz1ja2e 36 32 2011 2011 CD cord-001273-plz1ja2e 36 33 ) ) -RRB- cord-001273-plz1ja2e 36 34 . . . cord-001273-plz1ja2e 37 1 In in IN cord-001273-plz1ja2e 37 2 particular particular JJ cord-001273-plz1ja2e 37 3 , , , cord-001273-plz1ja2e 37 4 the the DT cord-001273-plz1ja2e 37 5 fate fate NN cord-001273-plz1ja2e 37 6 of of IN cord-001273-plz1ja2e 37 7 infection infection NN cord-001273-plz1ja2e 37 8 depends depend VBZ cord-001273-plz1ja2e 37 9 on on IN cord-001273-plz1ja2e 37 10 the the DT cord-001273-plz1ja2e 37 11 level level NN cord-001273-plz1ja2e 37 12 of of IN cord-001273-plz1ja2e 37 13 macrophage macrophage NN cord-001273-plz1ja2e 37 14 activation activation NN cord-001273-plz1ja2e 37 15 and and CC cord-001273-plz1ja2e 37 16 on on IN cord-001273-plz1ja2e 37 17 Listeria Listeria NNP cord-001273-plz1ja2e 37 18 ability ability NN cord-001273-plz1ja2e 37 19 to to TO cord-001273-plz1ja2e 37 20 counteract counteract VB cord-001273-plz1ja2e 37 21 bactericidal bactericidal JJ cord-001273-plz1ja2e 37 22 mechanisms mechanism NNS cord-001273-plz1ja2e 37 23 of of IN cord-001273-plz1ja2e 37 24 host host NN cord-001273-plz1ja2e 37 25 cells cell NNS cord-001273-plz1ja2e 37 26 ( ( -LRB- cord-001273-plz1ja2e 37 27 Shaughnessy Shaughnessy NNP cord-001273-plz1ja2e 37 28 and and CC cord-001273-plz1ja2e 37 29 Swanson Swanson NNP cord-001273-plz1ja2e 37 30 , , , cord-001273-plz1ja2e 37 31 2007 2007 CD cord-001273-plz1ja2e 37 32 ; ; : cord-001273-plz1ja2e 37 33 Corr Corr NNP cord-001273-plz1ja2e 37 34 and and CC cord-001273-plz1ja2e 37 35 O'Neill O'Neill NNP cord-001273-plz1ja2e 37 36 , , , cord-001273-plz1ja2e 37 37 2009 2009 CD cord-001273-plz1ja2e 37 38 ; ; : cord-001273-plz1ja2e 37 39 Stavru Stavru NNP cord-001273-plz1ja2e 37 40 et et NNP cord-001273-plz1ja2e 37 41 al al NNP cord-001273-plz1ja2e 37 42 . . NNP cord-001273-plz1ja2e 37 43 , , , cord-001273-plz1ja2e 37 44 2011 2011 CD cord-001273-plz1ja2e 37 45 ) ) -RRB- cord-001273-plz1ja2e 37 46 . . . cord-001273-plz1ja2e 38 1 Bacterial bacterial JJ cord-001273-plz1ja2e 38 2 escape escape NN cord-001273-plz1ja2e 38 3 from from IN cord-001273-plz1ja2e 38 4 the the DT cord-001273-plz1ja2e 38 5 phagosome phagosome NN cord-001273-plz1ja2e 38 6 and and CC cord-001273-plz1ja2e 38 7 avoidance avoidance NN cord-001273-plz1ja2e 38 8 of of IN cord-001273-plz1ja2e 38 9 autophagy autophagy NN cord-001273-plz1ja2e 38 10 for for IN cord-001273-plz1ja2e 38 11 intracytosolic intracytosolic JJ cord-001273-plz1ja2e 38 12 replication replication NN cord-001273-plz1ja2e 38 13 and and CC cord-001273-plz1ja2e 38 14 cell cell NN cord-001273-plz1ja2e 38 15 - - HYPH cord-001273-plz1ja2e 38 16 cell cell NN cord-001273-plz1ja2e 38 17 spread spread NN cord-001273-plz1ja2e 38 18 have have VBP cord-001273-plz1ja2e 38 19 been be VBN cord-001273-plz1ja2e 38 20 well well RB cord-001273-plz1ja2e 38 21 characterized characterize VBN cord-001273-plz1ja2e 38 22 . . . cord-001273-plz1ja2e 39 1 They -PRON- PRP cord-001273-plz1ja2e 39 2 have have VBP cord-001273-plz1ja2e 39 3 been be VBN cord-001273-plz1ja2e 39 4 shown show VBN cord-001273-plz1ja2e 39 5 to to TO cord-001273-plz1ja2e 39 6 depend depend VB cord-001273-plz1ja2e 39 7 on on IN cord-001273-plz1ja2e 39 8 five five CD cord-001273-plz1ja2e 39 9 major major JJ cord-001273-plz1ja2e 39 10 virulence virulence NN cord-001273-plz1ja2e 39 11 factors factor NNS cord-001273-plz1ja2e 39 12 : : : cord-001273-plz1ja2e 39 13 the the DT cord-001273-plz1ja2e 39 14 secreted secrete VBN cord-001273-plz1ja2e 39 15 pore pore NN cord-001273-plz1ja2e 39 16 - - HYPH cord-001273-plz1ja2e 39 17 forming form VBG cord-001273-plz1ja2e 39 18 toxin toxin NN cord-001273-plz1ja2e 39 19 listeriolysin listeriolysin FW cord-001273-plz1ja2e 39 20 O O NNP cord-001273-plz1ja2e 39 21 ( ( -LRB- cord-001273-plz1ja2e 39 22 LLO LLO NNP cord-001273-plz1ja2e 39 23 ) ) -RRB- cord-001273-plz1ja2e 39 24 and and CC cord-001273-plz1ja2e 39 25 two two CD cord-001273-plz1ja2e 39 26 phospholipases phospholipase NNS cord-001273-plz1ja2e 39 27 C C NNP cord-001273-plz1ja2e 39 28 ( ( -LRB- cord-001273-plz1ja2e 39 29 PlcA PlcA NNP cord-001273-plz1ja2e 39 30 and and CC cord-001273-plz1ja2e 39 31 PlcB PlcB NNP cord-001273-plz1ja2e 39 32 ) ) -RRB- cord-001273-plz1ja2e 39 33 for for IN cord-001273-plz1ja2e 39 34 vacuolar vacuolar NNP cord-001273-plz1ja2e 39 35 escape escape NNP cord-001273-plz1ja2e 39 36 , , , cord-001273-plz1ja2e 39 37 the the DT cord-001273-plz1ja2e 39 38 surface surface NN cord-001273-plz1ja2e 39 39 protein protein NN cord-001273-plz1ja2e 39 40 ActA ActA NNP cord-001273-plz1ja2e 39 41 for for IN cord-001273-plz1ja2e 39 42 actin actin NN cord-001273-plz1ja2e 39 43 - - HYPH cord-001273-plz1ja2e 39 44 based base VBN cord-001273-plz1ja2e 39 45 motility motility NN cord-001273-plz1ja2e 39 46 and and CC cord-001273-plz1ja2e 39 47 both both CC cord-001273-plz1ja2e 39 48 ActA ActA NNP cord-001273-plz1ja2e 39 49 and and CC cord-001273-plz1ja2e 39 50 a a DT cord-001273-plz1ja2e 39 51 surface surface NN cord-001273-plz1ja2e 39 52 protein protein NN cord-001273-plz1ja2e 39 53 of of IN cord-001273-plz1ja2e 39 54 the the DT cord-001273-plz1ja2e 39 55 internalin internalin NNP cord-001273-plz1ja2e 39 56 family family NN cord-001273-plz1ja2e 39 57 , , , cord-001273-plz1ja2e 39 58 InlK InlK NNP cord-001273-plz1ja2e 39 59 , , , cord-001273-plz1ja2e 39 60 for for IN cord-001273-plz1ja2e 39 61 autophagy autophagy NN cord-001273-plz1ja2e 39 62 evasion evasion NN cord-001273-plz1ja2e 39 63 ( ( -LRB- cord-001273-plz1ja2e 39 64 Cossart Cossart NNP cord-001273-plz1ja2e 39 65 , , , cord-001273-plz1ja2e 39 66 2011 2011 CD cord-001273-plz1ja2e 39 67 ; ; : cord-001273-plz1ja2e 39 68 Dortet Dortet NNP cord-001273-plz1ja2e 39 69 et et FW cord-001273-plz1ja2e 39 70 al al NNP cord-001273-plz1ja2e 39 71 . . NNP cord-001273-plz1ja2e 39 72 , , , cord-001273-plz1ja2e 39 73 2012 2012 CD cord-001273-plz1ja2e 39 74 ) ) -RRB- cord-001273-plz1ja2e 39 75 . . . cord-001273-plz1ja2e 40 1 Other other JJ cord-001273-plz1ja2e 40 2 strategies strategy NNS cord-001273-plz1ja2e 40 3 of of IN cord-001273-plz1ja2e 40 4 immune immune JJ cord-001273-plz1ja2e 40 5 escape escape NN cord-001273-plz1ja2e 40 6 that that WDT cord-001273-plz1ja2e 40 7 lead lead VBP cord-001273-plz1ja2e 40 8 to to IN cord-001273-plz1ja2e 40 9 the the DT cord-001273-plz1ja2e 40 10 modulation modulation NN cord-001273-plz1ja2e 40 11 of of IN cord-001273-plz1ja2e 40 12 cytokine cytokine NN cord-001273-plz1ja2e 40 13 expression expression NN cord-001273-plz1ja2e 40 14 occur occur VBP cord-001273-plz1ja2e 40 15 through through IN cord-001273-plz1ja2e 40 16 a a DT cord-001273-plz1ja2e 40 17 variety variety NN cord-001273-plz1ja2e 40 18 of of IN cord-001273-plz1ja2e 40 19 mechanisms mechanism NNS cord-001273-plz1ja2e 40 20 . . . cord-001273-plz1ja2e 41 1 Modifications modification NNS cord-001273-plz1ja2e 41 2 of of IN cord-001273-plz1ja2e 41 3 L. L. NNP cord-001273-plz1ja2e 41 4 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 41 5 peptidoglycan peptidoglycan NN cord-001273-plz1ja2e 41 6 by by IN cord-001273-plz1ja2e 41 7 the the DT cord-001273-plz1ja2e 41 8 N N NNP cord-001273-plz1ja2e 41 9 - - HYPH cord-001273-plz1ja2e 41 10 deacetylase deacetylase NNP cord-001273-plz1ja2e 41 11 PgdA PgdA NNP cord-001273-plz1ja2e 41 12 and and CC cord-001273-plz1ja2e 42 1 the the DT cord-001273-plz1ja2e 42 2 O o NN cord-001273-plz1ja2e 42 3 - - HYPH cord-001273-plz1ja2e 42 4 acetyl acetyl NN cord-001273-plz1ja2e 42 5 transferase transferase NN cord-001273-plz1ja2e 42 6 OatA OatA NNP cord-001273-plz1ja2e 42 7 prevent prevent VBP cord-001273-plz1ja2e 42 8 lysozyme lysozyme NN cord-001273-plz1ja2e 42 9 - - HYPH cord-001273-plz1ja2e 42 10 dependent dependent JJ cord-001273-plz1ja2e 42 11 release release NN cord-001273-plz1ja2e 42 12 of of IN cord-001273-plz1ja2e 42 13 microbe microbe NN cord-001273-plz1ja2e 42 14 - - HYPH cord-001273-plz1ja2e 42 15 associated associate VBN cord-001273-plz1ja2e 42 16 molecular molecular JJ cord-001273-plz1ja2e 42 17 patterns pattern NNS cord-001273-plz1ja2e 42 18 ( ( -LRB- cord-001273-plz1ja2e 42 19 MAMPs MAMPs NNP cord-001273-plz1ja2e 42 20 ) ) -RRB- cord-001273-plz1ja2e 42 21 , , , cord-001273-plz1ja2e 42 22 activation activation NN cord-001273-plz1ja2e 42 23 of of IN cord-001273-plz1ja2e 42 24 pathogen pathogen NN cord-001273-plz1ja2e 42 25 - - HYPH cord-001273-plz1ja2e 42 26 recognition recognition NN cord-001273-plz1ja2e 42 27 receptors receptor NNS cord-001273-plz1ja2e 42 28 ( ( -LRB- cord-001273-plz1ja2e 42 29 PRRs PRRs NNP cord-001273-plz1ja2e 42 30 ) ) -RRB- cord-001273-plz1ja2e 42 31 and and CC cord-001273-plz1ja2e 42 32 subsequent subsequent JJ cord-001273-plz1ja2e 42 33 production production NN cord-001273-plz1ja2e 42 34 of of IN cord-001273-plz1ja2e 42 35 pro pro JJ cord-001273-plz1ja2e 42 36 - - JJ cord-001273-plz1ja2e 42 37 inflammatory inflammatory JJ cord-001273-plz1ja2e 42 38 cytokines cytokine NNS cord-001273-plz1ja2e 42 39 ( ( -LRB- cord-001273-plz1ja2e 42 40 Boneca Boneca NNP cord-001273-plz1ja2e 42 41 et et NNP cord-001273-plz1ja2e 42 42 al al NNP cord-001273-plz1ja2e 42 43 . . . cord-001273-plz1ja2e 43 1 , , , cord-001273-plz1ja2e 43 2 2007 2007 CD cord-001273-plz1ja2e 43 3 ; ; : cord-001273-plz1ja2e 43 4 Aubry Aubry NNP cord-001273-plz1ja2e 43 5 et et NNP cord-001273-plz1ja2e 43 6 al al NNP cord-001273-plz1ja2e 43 7 . . NNP cord-001273-plz1ja2e 43 8 , , , cord-001273-plz1ja2e 43 9 2011 2011 CD cord-001273-plz1ja2e 43 10 ; ; : cord-001273-plz1ja2e 44 1 Rae Rae NNP cord-001273-plz1ja2e 44 2 et et NNP cord-001273-plz1ja2e 44 3 al al NNP cord-001273-plz1ja2e 44 4 . . NNP cord-001273-plz1ja2e 44 5 , , , cord-001273-plz1ja2e 44 6 2011 2011 CD cord-001273-plz1ja2e 44 7 ) ) -RRB- cord-001273-plz1ja2e 44 8 . . . cord-001273-plz1ja2e 45 1 The the DT cord-001273-plz1ja2e 45 2 toxin toxin NN cord-001273-plz1ja2e 45 3 LLO LLO NNP cord-001273-plz1ja2e 45 4 induces induce VBZ cord-001273-plz1ja2e 45 5 dephosphorylation dephosphorylation NN cord-001273-plz1ja2e 45 6 of of IN cord-001273-plz1ja2e 45 7 histone histone NN cord-001273-plz1ja2e 45 8 H3 H3 NNP cord-001273-plz1ja2e 45 9 and and CC cord-001273-plz1ja2e 45 10 deacetylation deacetylation NN cord-001273-plz1ja2e 45 11 of of IN cord-001273-plz1ja2e 45 12 histone histone NN cord-001273-plz1ja2e 45 13 H4 H4 NNP cord-001273-plz1ja2e 45 14 , , , cord-001273-plz1ja2e 45 15 which which WDT cord-001273-plz1ja2e 45 16 correlate correlate VBP cord-001273-plz1ja2e 45 17 with with IN cord-001273-plz1ja2e 45 18 decreased decreased JJ cord-001273-plz1ja2e 45 19 expression expression NN cord-001273-plz1ja2e 45 20 of of IN cord-001273-plz1ja2e 45 21 pro pro JJ cord-001273-plz1ja2e 45 22 - - JJ cord-001273-plz1ja2e 45 23 inflammatory inflammatory JJ cord-001273-plz1ja2e 45 24 genes gene NNS cord-001273-plz1ja2e 45 25 , , , cord-001273-plz1ja2e 45 26 such such JJ cord-001273-plz1ja2e 45 27 as as IN cord-001273-plz1ja2e 45 28 the the DT cord-001273-plz1ja2e 45 29 chemokine chemokine NN cord-001273-plz1ja2e 45 30 gene gene NN cord-001273-plz1ja2e 45 31 cxcl2 cxcl2 NN cord-001273-plz1ja2e 46 1 ( ( -LRB- cord-001273-plz1ja2e 46 2 Hamon Hamon NNP cord-001273-plz1ja2e 46 3 et et NNP cord-001273-plz1ja2e 46 4 al al NNP cord-001273-plz1ja2e 46 5 . . NNP cord-001273-plz1ja2e 46 6 , , , cord-001273-plz1ja2e 46 7 2007 2007 CD cord-001273-plz1ja2e 46 8 ) ) -RRB- cord-001273-plz1ja2e 46 9 . . . cord-001273-plz1ja2e 47 1 The the DT cord-001273-plz1ja2e 47 2 secreted secreted JJ cord-001273-plz1ja2e 47 3 internalin internalin NN cord-001273-plz1ja2e 47 4 InlC InlC NNP cord-001273-plz1ja2e 47 5 inhibits inhibit VBZ cord-001273-plz1ja2e 47 6 inflammation inflammation NN cord-001273-plz1ja2e 47 7 by by IN cord-001273-plz1ja2e 47 8 interacting interact VBG cord-001273-plz1ja2e 47 9 with with IN cord-001273-plz1ja2e 47 10 IKK IKK NNP cord-001273-plz1ja2e 47 11 - - HYPH cord-001273-plz1ja2e 47 12 α α NNP cord-001273-plz1ja2e 47 13 , , , cord-001273-plz1ja2e 47 14 a a DT cord-001273-plz1ja2e 47 15 component component NN cord-001273-plz1ja2e 47 16 of of IN cord-001273-plz1ja2e 47 17 the the DT cord-001273-plz1ja2e 47 18 IκB iκb NN cord-001273-plz1ja2e 47 19 - - HYPH cord-001273-plz1ja2e 47 20 kinase kinase NN cord-001273-plz1ja2e 47 21 complex complex NN cord-001273-plz1ja2e 47 22 , , , cord-001273-plz1ja2e 47 23 which which WDT cord-001273-plz1ja2e 47 24 is be VBZ cord-001273-plz1ja2e 47 25 essential essential JJ cord-001273-plz1ja2e 47 26 for for IN cord-001273-plz1ja2e 47 27 NF nf NN cord-001273-plz1ja2e 47 28 - - HYPH cord-001273-plz1ja2e 47 29 κB κb CD cord-001273-plz1ja2e 47 30 activation activation NN cord-001273-plz1ja2e 47 31 and and CC cord-001273-plz1ja2e 47 32 expression expression NN cord-001273-plz1ja2e 47 33 of of IN cord-001273-plz1ja2e 47 34 proinflammatory proinflammatory JJ cord-001273-plz1ja2e 47 35 genes gene NNS cord-001273-plz1ja2e 47 36 ( ( -LRB- cord-001273-plz1ja2e 47 37 Gouin Gouin NNP cord-001273-plz1ja2e 47 38 et et NNP cord-001273-plz1ja2e 47 39 al al NNP cord-001273-plz1ja2e 47 40 . . NNP cord-001273-plz1ja2e 47 41 , , , cord-001273-plz1ja2e 47 42 2010 2010 CD cord-001273-plz1ja2e 47 43 ) ) -RRB- cord-001273-plz1ja2e 47 44 . . . cord-001273-plz1ja2e 48 1 Other other JJ cord-001273-plz1ja2e 48 2 evasion evasion NN cord-001273-plz1ja2e 48 3 mechanisms mechanism NNS cord-001273-plz1ja2e 48 4 remain remain VBP cord-001273-plz1ja2e 48 5 to to TO cord-001273-plz1ja2e 48 6 be be VB cord-001273-plz1ja2e 48 7 characterized characterize VBN cord-001273-plz1ja2e 48 8 , , , cord-001273-plz1ja2e 48 9 such such JJ cord-001273-plz1ja2e 48 10 as as IN cord-001273-plz1ja2e 48 11 the the DT cord-001273-plz1ja2e 48 12 control control NN cord-001273-plz1ja2e 48 13 of of IN cord-001273-plz1ja2e 48 14 the the DT cord-001273-plz1ja2e 48 15 expression expression NN cord-001273-plz1ja2e 48 16 of of IN cord-001273-plz1ja2e 49 1 IL-6 IL-6 NNP cord-001273-plz1ja2e 49 2 by by IN cord-001273-plz1ja2e 49 3 the the DT cord-001273-plz1ja2e 49 4 surface surface NN cord-001273-plz1ja2e 49 5 internalin internalin NNP cord-001273-plz1ja2e 49 6 InlH InlH NNP cord-001273-plz1ja2e 50 1 ( ( -LRB- cord-001273-plz1ja2e 50 2 Personnic Personnic NNP cord-001273-plz1ja2e 50 3 et et NNP cord-001273-plz1ja2e 50 4 al al NNP cord-001273-plz1ja2e 50 5 . . NNP cord-001273-plz1ja2e 50 6 , , , cord-001273-plz1ja2e 50 7 2010 2010 CD cord-001273-plz1ja2e 50 8 ) ) -RRB- cord-001273-plz1ja2e 50 9 . . . cord-001273-plz1ja2e 51 1 L. L. NNP cord-001273-plz1ja2e 51 2 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 51 3 also also RB cord-001273-plz1ja2e 51 4 has have VBZ cord-001273-plz1ja2e 51 5 the the DT cord-001273-plz1ja2e 51 6 capacity capacity NN cord-001273-plz1ja2e 51 7 to to TO cord-001273-plz1ja2e 51 8 modulate modulate VB cord-001273-plz1ja2e 51 9 interferon interferon NN cord-001273-plz1ja2e 51 10 ( ( -LRB- cord-001273-plz1ja2e 51 11 IFN IFN NNP cord-001273-plz1ja2e 51 12 ) ) -RRB- cord-001273-plz1ja2e 51 13 production production NN cord-001273-plz1ja2e 51 14 during during IN cord-001273-plz1ja2e 51 15 infection infection NN cord-001273-plz1ja2e 51 16 . . . cord-001273-plz1ja2e 52 1 Type type NN cord-001273-plz1ja2e 52 2 I -PRON- PRP cord-001273-plz1ja2e 52 3 IFN IFN NNP cord-001273-plz1ja2e 52 4 production production NN cord-001273-plz1ja2e 52 5 by by IN cord-001273-plz1ja2e 52 6 infected infected JJ cord-001273-plz1ja2e 52 7 cells cell NNS cord-001273-plz1ja2e 52 8 can can MD cord-001273-plz1ja2e 52 9 be be VB cord-001273-plz1ja2e 52 10 controlled control VBN cord-001273-plz1ja2e 52 11 by by IN cord-001273-plz1ja2e 52 12 Listeria Listeria NNP cord-001273-plz1ja2e 52 13 multidrug multidrug NN cord-001273-plz1ja2e 52 14 efflux efflux NN cord-001273-plz1ja2e 52 15 pumps pump NNS cord-001273-plz1ja2e 52 16 MdrM MdrM NNP cord-001273-plz1ja2e 52 17 and and CC cord-001273-plz1ja2e 52 18 MdrT MdrT NNP cord-001273-plz1ja2e 52 19 , , , cord-001273-plz1ja2e 52 20 via via IN cord-001273-plz1ja2e 52 21 the the DT cord-001273-plz1ja2e 52 22 secretion secretion NN cord-001273-plz1ja2e 52 23 of of IN cord-001273-plz1ja2e 52 24 the the DT cord-001273-plz1ja2e 52 25 second second JJ cord-001273-plz1ja2e 52 26 messenger messenger NN cord-001273-plz1ja2e 52 27 cyclic cyclic JJ cord-001273-plz1ja2e 52 28 - - HYPH cord-001273-plz1ja2e 52 29 di di FW cord-001273-plz1ja2e 52 30 - - HYPH cord-001273-plz1ja2e 52 31 AMP AMP NNP cord-001273-plz1ja2e 52 32 ( ( -LRB- cord-001273-plz1ja2e 52 33 Crimmins Crimmins NNP cord-001273-plz1ja2e 52 34 et et NNP cord-001273-plz1ja2e 52 35 al al NNP cord-001273-plz1ja2e 52 36 . . NNP cord-001273-plz1ja2e 52 37 , , , cord-001273-plz1ja2e 52 38 2008 2008 CD cord-001273-plz1ja2e 52 39 ; ; . cord-001273-plz1ja2e 53 1 Woodward Woodward NNP cord-001273-plz1ja2e 53 2 et et NNP cord-001273-plz1ja2e 53 3 al al NNP cord-001273-plz1ja2e 53 4 . . . cord-001273-plz1ja2e 54 1 , , , cord-001273-plz1ja2e 54 2 2010 2010 CD cord-001273-plz1ja2e 54 3 ; ; : cord-001273-plz1ja2e 54 4 Schwartz Schwartz NNP cord-001273-plz1ja2e 54 5 et et NNP cord-001273-plz1ja2e 54 6 al al NNP cord-001273-plz1ja2e 54 7 . . NNP cord-001273-plz1ja2e 54 8 , , , cord-001273-plz1ja2e 54 9 2012 2012 CD cord-001273-plz1ja2e 54 10 ) ) -RRB- cord-001273-plz1ja2e 54 11 . . . cord-001273-plz1ja2e 55 1 Synthesis synthesis NN cord-001273-plz1ja2e 55 2 of of IN cord-001273-plz1ja2e 55 3 type type NN cord-001273-plz1ja2e 55 4 III III NNP cord-001273-plz1ja2e 55 5 IFN IFN NNP cord-001273-plz1ja2e 55 6 has have VBZ cord-001273-plz1ja2e 55 7 also also RB cord-001273-plz1ja2e 55 8 recently recently RB cord-001273-plz1ja2e 55 9 been be VBN cord-001273-plz1ja2e 55 10 shown show VBN cord-001273-plz1ja2e 55 11 to to TO cord-001273-plz1ja2e 55 12 be be VB cord-001273-plz1ja2e 55 13 tuned tune VBN cord-001273-plz1ja2e 55 14 by by IN cord-001273-plz1ja2e 55 15 Listeria Listeria NNP cord-001273-plz1ja2e 55 16 nucleomodulin nucleomodulin NN cord-001273-plz1ja2e 55 17 LntA LntA NNP cord-001273-plz1ja2e 55 18 ( ( -LRB- cord-001273-plz1ja2e 55 19 Lebreton Lebreton NNP cord-001273-plz1ja2e 55 20 et et FW cord-001273-plz1ja2e 55 21 al al NNP cord-001273-plz1ja2e 55 22 . . NNP cord-001273-plz1ja2e 55 23 , , , cord-001273-plz1ja2e 55 24 2011 2011 CD cord-001273-plz1ja2e 55 25 ) ) -RRB- cord-001273-plz1ja2e 55 26 . . . cord-001273-plz1ja2e 56 1 Our -PRON- PRP$ cord-001273-plz1ja2e 56 2 knowledge knowledge NN cord-001273-plz1ja2e 56 3 concerning concern VBG cord-001273-plz1ja2e 56 4 the the DT cord-001273-plz1ja2e 56 5 role role NN cord-001273-plz1ja2e 56 6 of of IN cord-001273-plz1ja2e 56 7 the the DT cord-001273-plz1ja2e 56 8 IFN IFN NNP cord-001273-plz1ja2e 56 9 cytokine cytokine NN cord-001273-plz1ja2e 56 10 family family NN cord-001273-plz1ja2e 56 11 during during IN cord-001273-plz1ja2e 56 12 listeriosis listeriosis NN cord-001273-plz1ja2e 56 13 has have VBZ cord-001273-plz1ja2e 56 14 rapidly rapidly RB cord-001273-plz1ja2e 56 15 expanded expand VBN cord-001273-plz1ja2e 56 16 in in IN cord-001273-plz1ja2e 56 17 the the DT cord-001273-plz1ja2e 56 18 last last JJ cord-001273-plz1ja2e 56 19 few few JJ cord-001273-plz1ja2e 56 20 years year NNS cord-001273-plz1ja2e 56 21 and and CC cord-001273-plz1ja2e 56 22 will will MD cord-001273-plz1ja2e 56 23 be be VB cord-001273-plz1ja2e 56 24 the the DT cord-001273-plz1ja2e 56 25 focus focus NN cord-001273-plz1ja2e 56 26 of of IN cord-001273-plz1ja2e 56 27 this this DT cord-001273-plz1ja2e 56 28 review review NN cord-001273-plz1ja2e 56 29 . . . cord-001273-plz1ja2e 57 1 IFNs IFNs NNP cord-001273-plz1ja2e 57 2 form form VBP cord-001273-plz1ja2e 57 3 a a DT cord-001273-plz1ja2e 57 4 family family NN cord-001273-plz1ja2e 57 5 of of IN cord-001273-plz1ja2e 57 6 proteins protein NNS cord-001273-plz1ja2e 57 7 secreted secrete VBN cord-001273-plz1ja2e 57 8 by by IN cord-001273-plz1ja2e 57 9 many many JJ cord-001273-plz1ja2e 57 10 cell cell NN cord-001273-plz1ja2e 57 11 types type NNS cord-001273-plz1ja2e 57 12 in in IN cord-001273-plz1ja2e 57 13 response response NN cord-001273-plz1ja2e 57 14 to to IN cord-001273-plz1ja2e 57 15 infection infection NN cord-001273-plz1ja2e 57 16 . . . cord-001273-plz1ja2e 58 1 They -PRON- PRP cord-001273-plz1ja2e 58 2 were be VBD cord-001273-plz1ja2e 58 3 originally originally RB cord-001273-plz1ja2e 58 4 named name VBN cord-001273-plz1ja2e 58 5 for for IN cord-001273-plz1ja2e 58 6 their -PRON- PRP$ cord-001273-plz1ja2e 58 7 capacity capacity NN cord-001273-plz1ja2e 58 8 to to TO cord-001273-plz1ja2e 58 9 interfere interfere VB cord-001273-plz1ja2e 58 10 with with IN cord-001273-plz1ja2e 58 11 viral viral JJ cord-001273-plz1ja2e 58 12 proliferation proliferation NN cord-001273-plz1ja2e 58 13 ( ( -LRB- cord-001273-plz1ja2e 58 14 Isaacs Isaacs NNP cord-001273-plz1ja2e 58 15 and and CC cord-001273-plz1ja2e 58 16 Lindemann Lindemann NNP cord-001273-plz1ja2e 58 17 , , , cord-001273-plz1ja2e 58 18 1957 1957 CD cord-001273-plz1ja2e 58 19 ) ) -RRB- cord-001273-plz1ja2e 58 20 . . . cord-001273-plz1ja2e 59 1 This this DT cord-001273-plz1ja2e 59 2 diverse diverse JJ cord-001273-plz1ja2e 59 3 family family NN cord-001273-plz1ja2e 59 4 is be VBZ cord-001273-plz1ja2e 59 5 composed compose VBN cord-001273-plz1ja2e 59 6 of of IN cord-001273-plz1ja2e 59 7 three three CD cord-001273-plz1ja2e 59 8 groups group NNS cord-001273-plz1ja2e 59 9 of of IN cord-001273-plz1ja2e 59 10 cytokines cytokine NNS cord-001273-plz1ja2e 59 11 , , , cord-001273-plz1ja2e 59 12 namely namely RB cord-001273-plz1ja2e 59 13 type type NN cord-001273-plz1ja2e 59 14 I- i- NN cord-001273-plz1ja2e 59 15 , , , cord-001273-plz1ja2e 59 16 type type NN cord-001273-plz1ja2e 59 17 II- II- NNP cord-001273-plz1ja2e 59 18 , , , cord-001273-plz1ja2e 59 19 and and CC cord-001273-plz1ja2e 59 20 type type NN cord-001273-plz1ja2e 59 21 III iii CD cord-001273-plz1ja2e 59 22 - - HYPH cord-001273-plz1ja2e 59 23 IFNs IFNs NNP cord-001273-plz1ja2e 59 24 , , , cord-001273-plz1ja2e 59 25 which which WDT cord-001273-plz1ja2e 59 26 are be VBP cord-001273-plz1ja2e 59 27 important important JJ cord-001273-plz1ja2e 59 28 components component NNS cord-001273-plz1ja2e 59 29 of of IN cord-001273-plz1ja2e 59 30 innate innate JJ cord-001273-plz1ja2e 59 31 immune immune JJ cord-001273-plz1ja2e 59 32 responses response NNS cord-001273-plz1ja2e 59 33 ( ( -LRB- cord-001273-plz1ja2e 59 34 Table table NN cord-001273-plz1ja2e 59 35 1 1 CD cord-001273-plz1ja2e 59 36 ) ) -RRB- cord-001273-plz1ja2e 59 37 . . . cord-001273-plz1ja2e 60 1 Type Type NNP cord-001273-plz1ja2e 60 2 I i NN cord-001273-plz1ja2e 60 3 - - HYPH cord-001273-plz1ja2e 60 4 IFNs ifn NNS cord-001273-plz1ja2e 60 5 consist consist VBP cord-001273-plz1ja2e 60 6 of of IN cord-001273-plz1ja2e 60 7 IFN IFN NNP cord-001273-plz1ja2e 60 8 - - HYPH cord-001273-plz1ja2e 60 9 α α NNP cord-001273-plz1ja2e 60 10 , , , cord-001273-plz1ja2e 60 11 IFN IFN NNP cord-001273-plz1ja2e 60 12 - - HYPH cord-001273-plz1ja2e 60 13 β β NNP cord-001273-plz1ja2e 60 14 , , , cord-001273-plz1ja2e 60 15 IFN IFN NNP cord-001273-plz1ja2e 60 16 - - HYPH cord-001273-plz1ja2e 60 17 δ δ NNP cord-001273-plz1ja2e 61 1 , , , cord-001273-plz1ja2e 61 2 IFN IFN NNP cord-001273-plz1ja2e 61 3 - - HYPH cord-001273-plz1ja2e 61 4 ε ε NNP cord-001273-plz1ja2e 61 5 , , , cord-001273-plz1ja2e 61 6 IFN IFN NNP cord-001273-plz1ja2e 61 7 - - HYPH cord-001273-plz1ja2e 61 8 ζ ζ NNP cord-001273-plz1ja2e 61 9 , , , cord-001273-plz1ja2e 61 10 IFNκ IFNκ NNP cord-001273-plz1ja2e 61 11 , , , cord-001273-plz1ja2e 61 12 IFN IFN NNP cord-001273-plz1ja2e 61 13 - - HYPH cord-001273-plz1ja2e 61 14 ν ν NNP cord-001273-plz1ja2e 61 15 , , , cord-001273-plz1ja2e 61 16 IFN IFN NNP cord-001273-plz1ja2e 61 17 - - HYPH cord-001273-plz1ja2e 61 18 τ τ NNP cord-001273-plz1ja2e 61 19 , , , cord-001273-plz1ja2e 61 20 and and CC cord-001273-plz1ja2e 61 21 IFN IFN NNP cord-001273-plz1ja2e 61 22 - - HYPH cord-001273-plz1ja2e 61 23 ω ω NNP cord-001273-plz1ja2e 61 24 ( ( -LRB- cord-001273-plz1ja2e 61 25 Levy Levy NNP cord-001273-plz1ja2e 61 26 et et FW cord-001273-plz1ja2e 61 27 al al NNP cord-001273-plz1ja2e 61 28 . . NNP cord-001273-plz1ja2e 61 29 , , , cord-001273-plz1ja2e 61 30 2011 2011 CD cord-001273-plz1ja2e 61 31 ) ) -RRB- cord-001273-plz1ja2e 61 32 . . . cord-001273-plz1ja2e 62 1 Type Type NNP cord-001273-plz1ja2e 62 2 II II NNP cord-001273-plz1ja2e 62 3 - - HYPH cord-001273-plz1ja2e 62 4 IFN IFN NNP cord-001273-plz1ja2e 62 5 is be VBZ cord-001273-plz1ja2e 62 6 composed compose VBN cord-001273-plz1ja2e 62 7 of of IN cord-001273-plz1ja2e 62 8 a a DT cord-001273-plz1ja2e 62 9 single single JJ cord-001273-plz1ja2e 62 10 cytokine cytokine NN cord-001273-plz1ja2e 62 11 , , , cord-001273-plz1ja2e 62 12 IFN IFN NNP cord-001273-plz1ja2e 62 13 - - HYPH cord-001273-plz1ja2e 62 14 γ γ NNP cord-001273-plz1ja2e 62 15 ( ( -LRB- cord-001273-plz1ja2e 62 16 Pestka Pestka NNP cord-001273-plz1ja2e 62 17 et et NNP cord-001273-plz1ja2e 62 18 al al NNP cord-001273-plz1ja2e 62 19 . . NNP cord-001273-plz1ja2e 62 20 , , , cord-001273-plz1ja2e 62 21 2004 2004 CD cord-001273-plz1ja2e 62 22 ) ) -RRB- cord-001273-plz1ja2e 62 23 . . . cord-001273-plz1ja2e 63 1 Type Type NNP cord-001273-plz1ja2e 63 2 III III NNP cord-001273-plz1ja2e 63 3 - - HYPH cord-001273-plz1ja2e 63 4 IFNs IFNs NNP cord-001273-plz1ja2e 63 5 are be VBP cord-001273-plz1ja2e 63 6 IFN IFN NNP cord-001273-plz1ja2e 63 7 - - HYPH cord-001273-plz1ja2e 63 8 λ1 λ1 NNP cord-001273-plz1ja2e 63 9 , , , cord-001273-plz1ja2e 63 10 IFN IFN NNP cord-001273-plz1ja2e 63 11 - - HYPH cord-001273-plz1ja2e 63 12 λ2 λ2 NNP cord-001273-plz1ja2e 63 13 , , , cord-001273-plz1ja2e 63 14 and and CC cord-001273-plz1ja2e 63 15 IFN IFN NNP cord-001273-plz1ja2e 63 16 - - HYPH cord-001273-plz1ja2e 63 17 λ3 λ3 NNP cord-001273-plz1ja2e 63 18 ( ( -LRB- cord-001273-plz1ja2e 63 19 formerly formerly RB cord-001273-plz1ja2e 63 20 IL-29 IL-29 NNP cord-001273-plz1ja2e 63 21 , , , cord-001273-plz1ja2e 63 22 IL-28A IL-28A NNP cord-001273-plz1ja2e 63 23 , , , cord-001273-plz1ja2e 63 24 and and CC cord-001273-plz1ja2e 63 25 IL-28B il-28b NN cord-001273-plz1ja2e 63 26 ) ) -RRB- cord-001273-plz1ja2e 64 1 and and CC cord-001273-plz1ja2e 64 2 IFN IFN NNP cord-001273-plz1ja2e 64 3 - - HYPH cord-001273-plz1ja2e 64 4 λ4 λ4 NNP cord-001273-plz1ja2e 64 5 ( ( -LRB- cord-001273-plz1ja2e 64 6 Kotenko Kotenko NNP cord-001273-plz1ja2e 64 7 , , , cord-001273-plz1ja2e 64 8 2011 2011 CD cord-001273-plz1ja2e 64 9 ; ; : cord-001273-plz1ja2e 64 10 Prokunina Prokunina NNP cord-001273-plz1ja2e 64 11 - - HYPH cord-001273-plz1ja2e 64 12 Olsson Olsson NNP cord-001273-plz1ja2e 64 13 et et NNP cord-001273-plz1ja2e 64 14 al al NNP cord-001273-plz1ja2e 64 15 . . NNP cord-001273-plz1ja2e 64 16 , , , cord-001273-plz1ja2e 64 17 2013 2013 CD cord-001273-plz1ja2e 64 18 ) ) -RRB- cord-001273-plz1ja2e 64 19 . . . cord-001273-plz1ja2e 65 1 Type type NN cord-001273-plz1ja2e 65 2 I i NN cord-001273-plz1ja2e 65 3 - - HYPH cord-001273-plz1ja2e 65 4 and and CC cord-001273-plz1ja2e 65 5 type type NN cord-001273-plz1ja2e 65 6 III iii CD cord-001273-plz1ja2e 65 7 - - HYPH cord-001273-plz1ja2e 65 8 IFNs IFNs NNP cord-001273-plz1ja2e 65 9 have have VBP cord-001273-plz1ja2e 65 10 similar similar JJ cord-001273-plz1ja2e 65 11 signal signal NN cord-001273-plz1ja2e 65 12 transduction transduction NN cord-001273-plz1ja2e 65 13 systems system NNS cord-001273-plz1ja2e 65 14 ( ( -LRB- cord-001273-plz1ja2e 65 15 see see VB cord-001273-plz1ja2e 65 16 below below RB cord-001273-plz1ja2e 65 17 ) ) -RRB- cord-001273-plz1ja2e 65 18 and and CC cord-001273-plz1ja2e 65 19 are be VBP cord-001273-plz1ja2e 65 20 phylogenetically phylogenetically RB cord-001273-plz1ja2e 65 21 closer close JJR cord-001273-plz1ja2e 65 22 from from IN cord-001273-plz1ja2e 65 23 each each DT cord-001273-plz1ja2e 65 24 other other JJ cord-001273-plz1ja2e 65 25 than than IN cord-001273-plz1ja2e 65 26 type type NN cord-001273-plz1ja2e 65 27 II II NNP cord-001273-plz1ja2e 65 28 - - HYPH cord-001273-plz1ja2e 65 29 IFN IFN NNP cord-001273-plz1ja2e 65 30 ( ( -LRB- cord-001273-plz1ja2e 65 31 Pestka Pestka NNP cord-001273-plz1ja2e 65 32 et et NNP cord-001273-plz1ja2e 65 33 al al NNP cord-001273-plz1ja2e 65 34 . . NNP cord-001273-plz1ja2e 65 35 , , , cord-001273-plz1ja2e 65 36 2004 2004 CD cord-001273-plz1ja2e 65 37 ) ) -RRB- cord-001273-plz1ja2e 65 38 . . . cord-001273-plz1ja2e 66 1 Sequence sequence NN cord-001273-plz1ja2e 66 2 conservation conservation NN cord-001273-plz1ja2e 66 3 and and CC cord-001273-plz1ja2e 66 4 chromosome chromosome NN cord-001273-plz1ja2e 66 5 location location NN cord-001273-plz1ja2e 66 6 suggest suggest VBP cord-001273-plz1ja2e 66 7 that that IN cord-001273-plz1ja2e 66 8 type type NN cord-001273-plz1ja2e 66 9 I I NNP cord-001273-plz1ja2e 66 10 - - HYPH cord-001273-plz1ja2e 66 11 IFN IFN NNP cord-001273-plz1ja2e 66 12 genes gene NNS cord-001273-plz1ja2e 66 13 evolved evolve VBD cord-001273-plz1ja2e 66 14 from from IN cord-001273-plz1ja2e 66 15 a a DT cord-001273-plz1ja2e 66 16 single single JJ cord-001273-plz1ja2e 66 17 ancestor ancestor NN cord-001273-plz1ja2e 66 18 through through IN cord-001273-plz1ja2e 66 19 duplication duplication NN cord-001273-plz1ja2e 66 20 . . . cord-001273-plz1ja2e 67 1 However however RB cord-001273-plz1ja2e 67 2 , , , cord-001273-plz1ja2e 67 3 the the DT cord-001273-plz1ja2e 67 4 extent extent NN cord-001273-plz1ja2e 67 5 of of IN cord-001273-plz1ja2e 67 6 type type NN cord-001273-plz1ja2e 67 7 I I NNP cord-001273-plz1ja2e 67 8 - - HYPH cord-001273-plz1ja2e 67 9 IFN IFN NNP cord-001273-plz1ja2e 67 10 gene gene NN cord-001273-plz1ja2e 67 11 diversification diversification NN cord-001273-plz1ja2e 67 12 varies vary VBZ cord-001273-plz1ja2e 67 13 greatly greatly RB cord-001273-plz1ja2e 67 14 depending depend VBG cord-001273-plz1ja2e 67 15 on on IN cord-001273-plz1ja2e 67 16 the the DT cord-001273-plz1ja2e 67 17 species specie NNS cord-001273-plz1ja2e 67 18 ( ( -LRB- cord-001273-plz1ja2e 67 19 Pestka Pestka NNP cord-001273-plz1ja2e 67 20 et et NNP cord-001273-plz1ja2e 67 21 al al NNP cord-001273-plz1ja2e 67 22 . . NNP cord-001273-plz1ja2e 67 23 , , , cord-001273-plz1ja2e 67 24 2004 2004 CD cord-001273-plz1ja2e 67 25 ) ) -RRB- cord-001273-plz1ja2e 67 26 . . . cord-001273-plz1ja2e 68 1 Generally generally RB cord-001273-plz1ja2e 68 2 , , , cord-001273-plz1ja2e 68 3 a a DT cord-001273-plz1ja2e 68 4 single single JJ cord-001273-plz1ja2e 68 5 gene gene NN cord-001273-plz1ja2e 68 6 encodes encode VBZ cord-001273-plz1ja2e 68 7 the the DT cord-001273-plz1ja2e 68 8 type type NN cord-001273-plz1ja2e 68 9 I I NNP cord-001273-plz1ja2e 68 10 - - HYPH cord-001273-plz1ja2e 68 11 IFN IFN NNP cord-001273-plz1ja2e 68 12 in in IN cord-001273-plz1ja2e 68 13 fish fish NN cord-001273-plz1ja2e 68 14 . . . cord-001273-plz1ja2e 69 1 In in IN cord-001273-plz1ja2e 69 2 contrast contrast NN cord-001273-plz1ja2e 69 3 , , , cord-001273-plz1ja2e 69 4 multiple multiple JJ cord-001273-plz1ja2e 69 5 gene gene NN cord-001273-plz1ja2e 69 6 duplications duplication NNS cord-001273-plz1ja2e 69 7 and and CC cord-001273-plz1ja2e 69 8 diversification diversification NN cord-001273-plz1ja2e 69 9 led lead VBD cord-001273-plz1ja2e 69 10 to to IN cord-001273-plz1ja2e 69 11 the the DT cord-001273-plz1ja2e 69 12 emergence emergence NN cord-001273-plz1ja2e 69 13 of of IN cord-001273-plz1ja2e 69 14 sub sub NN cord-001273-plz1ja2e 69 15 - - NNS cord-001273-plz1ja2e 69 16 types type NNS cord-001273-plz1ja2e 69 17 of of IN cord-001273-plz1ja2e 69 18 type type NN cord-001273-plz1ja2e 69 19 I i NN cord-001273-plz1ja2e 69 20 - - HYPH cord-001273-plz1ja2e 69 21 IFNs ifn NNS cord-001273-plz1ja2e 69 22 in in IN cord-001273-plz1ja2e 69 23 mammals mammal NNS cord-001273-plz1ja2e 69 24 ( ( -LRB- cord-001273-plz1ja2e 69 25 Table table NN cord-001273-plz1ja2e 69 26 1 1 CD cord-001273-plz1ja2e 69 27 ) ) -RRB- cord-001273-plz1ja2e 69 28 . . . cord-001273-plz1ja2e 70 1 Gene gene NN cord-001273-plz1ja2e 70 2 duplication duplication NN cord-001273-plz1ja2e 70 3 varies vary VBZ cord-001273-plz1ja2e 70 4 also also RB cord-001273-plz1ja2e 70 5 within within IN cord-001273-plz1ja2e 70 6 each each DT cord-001273-plz1ja2e 70 7 sub sub NN cord-001273-plz1ja2e 70 8 - - NN cord-001273-plz1ja2e 70 9 type type NN cord-001273-plz1ja2e 70 10 . . . cord-001273-plz1ja2e 71 1 A a DT cord-001273-plz1ja2e 71 2 single single JJ cord-001273-plz1ja2e 71 3 IFN IFN NNP cord-001273-plz1ja2e 71 4 - - HYPH cord-001273-plz1ja2e 71 5 β β NN cord-001273-plz1ja2e 71 6 gene gene NN cord-001273-plz1ja2e 71 7 is be VBZ cord-001273-plz1ja2e 71 8 found find VBN cord-001273-plz1ja2e 71 9 in in IN cord-001273-plz1ja2e 71 10 the the DT cord-001273-plz1ja2e 71 11 human human NN cord-001273-plz1ja2e 71 12 and and CC cord-001273-plz1ja2e 71 13 mouse mouse NN cord-001273-plz1ja2e 71 14 genomes genome NNS cord-001273-plz1ja2e 71 15 ( ( -LRB- cord-001273-plz1ja2e 71 16 Decker Decker NNP cord-001273-plz1ja2e 71 17 et et NNP cord-001273-plz1ja2e 71 18 al al NNP cord-001273-plz1ja2e 71 19 . . NNP cord-001273-plz1ja2e 71 20 , , , cord-001273-plz1ja2e 71 21 2005 2005 CD cord-001273-plz1ja2e 71 22 ; ; : cord-001273-plz1ja2e 71 23 Honda Honda NNP cord-001273-plz1ja2e 71 24 et et NNP cord-001273-plz1ja2e 71 25 al al NNP cord-001273-plz1ja2e 71 26 . . . cord-001273-plz1ja2e 72 1 , , , cord-001273-plz1ja2e 72 2 2006 2006 CD cord-001273-plz1ja2e 72 3 ; ; : cord-001273-plz1ja2e 72 4 Durbin Durbin NNP cord-001273-plz1ja2e 72 5 et et NNP cord-001273-plz1ja2e 72 6 al al NNP cord-001273-plz1ja2e 72 7 . . NNP cord-001273-plz1ja2e 72 8 , , , cord-001273-plz1ja2e 72 9 2013 2013 CD cord-001273-plz1ja2e 72 10 ) ) -RRB- cord-001273-plz1ja2e 72 11 . . . cord-001273-plz1ja2e 73 1 In in IN cord-001273-plz1ja2e 73 2 contrast contrast NN cord-001273-plz1ja2e 73 3 13 13 CD cord-001273-plz1ja2e 73 4 IFN IFN NNP cord-001273-plz1ja2e 73 5 - - HYPH cord-001273-plz1ja2e 73 6 α α NNP cord-001273-plz1ja2e 73 7 genes gene NNS cord-001273-plz1ja2e 73 8 and and CC cord-001273-plz1ja2e 73 9 one one CD cord-001273-plz1ja2e 73 10 pseudogene pseudogene NN cord-001273-plz1ja2e 73 11 and and CC cord-001273-plz1ja2e 73 12 14 14 CD cord-001273-plz1ja2e 73 13 IFN IFN NNP cord-001273-plz1ja2e 73 14 - - HYPH cord-001273-plz1ja2e 73 15 α α NNP cord-001273-plz1ja2e 73 16 genes gene NNS cord-001273-plz1ja2e 73 17 and and CC cord-001273-plz1ja2e 73 18 three three CD cord-001273-plz1ja2e 73 19 pseudogenes pseudogene NNS cord-001273-plz1ja2e 73 20 are be VBP cord-001273-plz1ja2e 73 21 found find VBN cord-001273-plz1ja2e 73 22 in in IN cord-001273-plz1ja2e 73 23 the the DT cord-001273-plz1ja2e 73 24 human human NN cord-001273-plz1ja2e 73 25 and and CC cord-001273-plz1ja2e 73 26 mouse mouse NN cord-001273-plz1ja2e 73 27 genomes genome NNS cord-001273-plz1ja2e 73 28 , , , cord-001273-plz1ja2e 73 29 respectively respectively RB cord-001273-plz1ja2e 73 30 ( ( -LRB- cord-001273-plz1ja2e 73 31 van van NNP cord-001273-plz1ja2e 73 32 Pesch Pesch NNP cord-001273-plz1ja2e 73 33 et et NNP cord-001273-plz1ja2e 73 34 al al NNP cord-001273-plz1ja2e 73 35 . . . cord-001273-plz1ja2e 74 1 , , , cord-001273-plz1ja2e 74 2 2004 2004 CD cord-001273-plz1ja2e 74 3 ; ; : cord-001273-plz1ja2e 74 4 Durbin Durbin NNP cord-001273-plz1ja2e 74 5 et et NNP cord-001273-plz1ja2e 74 6 al al NNP cord-001273-plz1ja2e 74 7 . . NNP cord-001273-plz1ja2e 74 8 , , , cord-001273-plz1ja2e 74 9 2013 2013 CD cord-001273-plz1ja2e 74 10 ) ) -RRB- cord-001273-plz1ja2e 74 11 . . . cord-001273-plz1ja2e 75 1 A a DT cord-001273-plz1ja2e 75 2 single single JJ cord-001273-plz1ja2e 75 3 gene gene NN cord-001273-plz1ja2e 75 4 encodes encode VBZ cord-001273-plz1ja2e 75 5 type type NN cord-001273-plz1ja2e 75 6 II II NNP cord-001273-plz1ja2e 75 7 - - HYPH cord-001273-plz1ja2e 75 8 IFN IFN NNP cord-001273-plz1ja2e 75 9 and and CC cord-001273-plz1ja2e 75 10 four four CD cord-001273-plz1ja2e 75 11 genes gene NNS cord-001273-plz1ja2e 75 12 encode encode VBP cord-001273-plz1ja2e 75 13 type type NN cord-001273-plz1ja2e 75 14 III III NNP cord-001273-plz1ja2e 75 15 - - HYPH cord-001273-plz1ja2e 75 16 IFNs IFNs NNP cord-001273-plz1ja2e 75 17 in in IN cord-001273-plz1ja2e 75 18 human human NN cord-001273-plz1ja2e 76 1 ( ( -LRB- cord-001273-plz1ja2e 76 2 Decker Decker NNP cord-001273-plz1ja2e 76 3 et et NNP cord-001273-plz1ja2e 76 4 al al NNP cord-001273-plz1ja2e 76 5 . . . cord-001273-plz1ja2e 77 1 , , , cord-001273-plz1ja2e 77 2 2005 2005 CD cord-001273-plz1ja2e 77 3 ; ; : cord-001273-plz1ja2e 77 4 Levy Levy NNP cord-001273-plz1ja2e 77 5 et et NNP cord-001273-plz1ja2e 77 6 al al NNP cord-001273-plz1ja2e 77 7 . . NNP cord-001273-plz1ja2e 77 8 , , , cord-001273-plz1ja2e 77 9 2011 2011 CD cord-001273-plz1ja2e 77 10 ) ) -RRB- cord-001273-plz1ja2e 77 11 . . . cord-001273-plz1ja2e 78 1 Of of IN cord-001273-plz1ja2e 78 2 note note NN cord-001273-plz1ja2e 78 3 , , , cord-001273-plz1ja2e 78 4 IFN IFN NNP cord-001273-plz1ja2e 78 5 - - HYPH cord-001273-plz1ja2e 78 6 λ1 λ1 NNP cord-001273-plz1ja2e 78 7 and and CC cord-001273-plz1ja2e 78 8 IFN IFN NNP cord-001273-plz1ja2e 78 9 - - HYPH cord-001273-plz1ja2e 78 10 λ4 λ4 NNP cord-001273-plz1ja2e 78 11 are be VBP cord-001273-plz1ja2e 78 12 pseudogenes pseudogene NNS cord-001273-plz1ja2e 78 13 in in IN cord-001273-plz1ja2e 78 14 mice mouse NNS cord-001273-plz1ja2e 78 15 , , , cord-001273-plz1ja2e 78 16 which which WDT cord-001273-plz1ja2e 78 17 prevents prevent VBZ cord-001273-plz1ja2e 78 18 the the DT cord-001273-plz1ja2e 78 19 study study NN cord-001273-plz1ja2e 78 20 of of IN cord-001273-plz1ja2e 78 21 these these DT cord-001273-plz1ja2e 78 22 cytokines cytokine NNS cord-001273-plz1ja2e 78 23 in in IN cord-001273-plz1ja2e 78 24 this this DT cord-001273-plz1ja2e 78 25 animal animal NN cord-001273-plz1ja2e 78 26 model model NN cord-001273-plz1ja2e 78 27 ( ( -LRB- cord-001273-plz1ja2e 78 28 Table table NN cord-001273-plz1ja2e 78 29 1 1 CD cord-001273-plz1ja2e 78 30 ) ) -RRB- cord-001273-plz1ja2e 79 1 ( ( -LRB- cord-001273-plz1ja2e 79 2 Fox Fox NNP cord-001273-plz1ja2e 79 3 et et FW cord-001273-plz1ja2e 79 4 al al NNP cord-001273-plz1ja2e 79 5 . . NNP cord-001273-plz1ja2e 79 6 , , , cord-001273-plz1ja2e 79 7 2009 2009 CD cord-001273-plz1ja2e 79 8 ) ) -RRB- cord-001273-plz1ja2e 79 9 . . . cord-001273-plz1ja2e 80 1 IFNs IFNs NNP cord-001273-plz1ja2e 80 2 are be VBP cord-001273-plz1ja2e 80 3 important important JJ cord-001273-plz1ja2e 80 4 components component NNS cord-001273-plz1ja2e 80 5 of of IN cord-001273-plz1ja2e 80 6 the the DT cord-001273-plz1ja2e 80 7 immune immune JJ cord-001273-plz1ja2e 80 8 system system NN cord-001273-plz1ja2e 80 9 , , , cord-001273-plz1ja2e 80 10 which which WDT cord-001273-plz1ja2e 80 11 generally generally RB cord-001273-plz1ja2e 80 12 trigger trigger VBP cord-001273-plz1ja2e 80 13 cellular cellular JJ cord-001273-plz1ja2e 80 14 protective protective JJ cord-001273-plz1ja2e 80 15 defenses defense NNS cord-001273-plz1ja2e 80 16 in in IN cord-001273-plz1ja2e 80 17 response response NN cord-001273-plz1ja2e 80 18 to to IN cord-001273-plz1ja2e 80 19 infection infection NN cord-001273-plz1ja2e 80 20 or or CC cord-001273-plz1ja2e 80 21 tumor tumor NN cord-001273-plz1ja2e 80 22 formation formation NN cord-001273-plz1ja2e 80 23 . . . cord-001273-plz1ja2e 81 1 Type type NN cord-001273-plz1ja2e 81 2 - - HYPH cord-001273-plz1ja2e 81 3 II II NNP cord-001273-plz1ja2e 81 4 IFN IFN NNP cord-001273-plz1ja2e 81 5 ( ( -LRB- cord-001273-plz1ja2e 81 6 IFN IFN NNP cord-001273-plz1ja2e 81 7 - - HYPH cord-001273-plz1ja2e 81 8 γ γ NNP cord-001273-plz1ja2e 81 9 ) ) -RRB- cord-001273-plz1ja2e 81 10 is be VBZ cord-001273-plz1ja2e 81 11 a a DT cord-001273-plz1ja2e 81 12 paradigm paradigm NN cord-001273-plz1ja2e 81 13 for for IN cord-001273-plz1ja2e 81 14 this this DT cord-001273-plz1ja2e 81 15 , , , cord-001273-plz1ja2e 81 16 being be VBG cord-001273-plz1ja2e 81 17 an an DT cord-001273-plz1ja2e 81 18 important important JJ cord-001273-plz1ja2e 81 19 mediator mediator NN cord-001273-plz1ja2e 81 20 of of IN cord-001273-plz1ja2e 81 21 innate innate JJ cord-001273-plz1ja2e 81 22 and and CC cord-001273-plz1ja2e 81 23 adaptive adaptive JJ cord-001273-plz1ja2e 81 24 immune immune JJ cord-001273-plz1ja2e 81 25 responses response NNS cord-001273-plz1ja2e 81 26 with with IN cord-001273-plz1ja2e 81 27 a a DT cord-001273-plz1ja2e 81 28 key key JJ cord-001273-plz1ja2e 81 29 role role NN cord-001273-plz1ja2e 81 30 in in IN cord-001273-plz1ja2e 81 31 clearance clearance NN cord-001273-plz1ja2e 81 32 of of IN cord-001273-plz1ja2e 81 33 viral viral JJ cord-001273-plz1ja2e 81 34 and and CC cord-001273-plz1ja2e 81 35 bacterial bacterial JJ cord-001273-plz1ja2e 81 36 pathogens pathogen NNS cord-001273-plz1ja2e 81 37 and and CC cord-001273-plz1ja2e 81 38 in in IN cord-001273-plz1ja2e 81 39 tumor tumor NN cord-001273-plz1ja2e 81 40 control control NN cord-001273-plz1ja2e 81 41 . . . cord-001273-plz1ja2e 82 1 IFN IFN NNP cord-001273-plz1ja2e 82 2 - - HYPH cord-001273-plz1ja2e 82 3 γ γ NNP cord-001273-plz1ja2e 82 4 was be VBD cord-001273-plz1ja2e 82 5 first first RB cord-001273-plz1ja2e 82 6 described describe VBN cord-001273-plz1ja2e 82 7 as as IN cord-001273-plz1ja2e 82 8 an an DT cord-001273-plz1ja2e 82 9 antiviral antiviral JJ cord-001273-plz1ja2e 82 10 protein protein NN cord-001273-plz1ja2e 82 11 ( ( -LRB- cord-001273-plz1ja2e 82 12 Wheelock Wheelock NNP cord-001273-plz1ja2e 82 13 and and CC cord-001273-plz1ja2e 82 14 Sibley Sibley NNP cord-001273-plz1ja2e 82 15 , , , cord-001273-plz1ja2e 82 16 1965 1965 CD cord-001273-plz1ja2e 82 17 ) ) -RRB- cord-001273-plz1ja2e 82 18 , , , cord-001273-plz1ja2e 82 19 but but CC cord-001273-plz1ja2e 82 20 is be VBZ cord-001273-plz1ja2e 82 21 now now RB cord-001273-plz1ja2e 82 22 known know VBN cord-001273-plz1ja2e 82 23 to to TO cord-001273-plz1ja2e 82 24 exhibit exhibit VB cord-001273-plz1ja2e 82 25 broader broad JJR cord-001273-plz1ja2e 82 26 biological biological JJ cord-001273-plz1ja2e 82 27 activities activity NNS cord-001273-plz1ja2e 82 28 , , , cord-001273-plz1ja2e 82 29 non non JJ cord-001273-plz1ja2e 82 30 - - JJ cord-001273-plz1ja2e 82 31 redundant redundant JJ cord-001273-plz1ja2e 82 32 with with IN cord-001273-plz1ja2e 82 33 that that DT cord-001273-plz1ja2e 82 34 of of IN cord-001273-plz1ja2e 82 35 other other JJ cord-001273-plz1ja2e 82 36 types type NNS cord-001273-plz1ja2e 82 37 of of IN cord-001273-plz1ja2e 82 38 IFNs ifn NNS cord-001273-plz1ja2e 82 39 . . . cord-001273-plz1ja2e 83 1 The the DT cord-001273-plz1ja2e 83 2 crucial crucial JJ cord-001273-plz1ja2e 83 3 role role NN cord-001273-plz1ja2e 83 4 of of IN cord-001273-plz1ja2e 83 5 IFN IFN NNP cord-001273-plz1ja2e 83 6 - - HYPH cord-001273-plz1ja2e 83 7 γ γ NN cord-001273-plz1ja2e 83 8 in in IN cord-001273-plz1ja2e 83 9 immunity immunity NN cord-001273-plz1ja2e 83 10 to to IN cord-001273-plz1ja2e 83 11 infection infection NN cord-001273-plz1ja2e 83 12 is be VBZ cord-001273-plz1ja2e 83 13 reflected reflect VBN cord-001273-plz1ja2e 83 14 by by IN cord-001273-plz1ja2e 83 15 the the DT cord-001273-plz1ja2e 83 16 phenotype phenotype NN cord-001273-plz1ja2e 83 17 of of IN cord-001273-plz1ja2e 83 18 mice mouse NNS cord-001273-plz1ja2e 83 19 lacking lack VBG cord-001273-plz1ja2e 83 20 the the DT cord-001273-plz1ja2e 83 21 IFN IFN NNP cord-001273-plz1ja2e 83 22 - - HYPH cord-001273-plz1ja2e 83 23 γ γ NN cord-001273-plz1ja2e 83 24 receptor receptor NN cord-001273-plz1ja2e 83 25 or or CC cord-001273-plz1ja2e 83 26 the the DT cord-001273-plz1ja2e 83 27 IFN IFN NNP cord-001273-plz1ja2e 83 28 - - HYPH cord-001273-plz1ja2e 83 29 γ γ NNP cord-001273-plz1ja2e 83 30 gene gene NN cord-001273-plz1ja2e 83 31 , , , cord-001273-plz1ja2e 83 32 which which WDT cord-001273-plz1ja2e 83 33 are be VBP cord-001273-plz1ja2e 83 34 highly highly RB cord-001273-plz1ja2e 83 35 susceptible susceptible JJ cord-001273-plz1ja2e 83 36 to to IN cord-001273-plz1ja2e 83 37 Mycobacterium Mycobacterium NNP cord-001273-plz1ja2e 83 38 bovis bovis NN cord-001273-plz1ja2e 83 39 BCG BCG NNP cord-001273-plz1ja2e 83 40 infection infection NN cord-001273-plz1ja2e 84 1 ( ( -LRB- cord-001273-plz1ja2e 84 2 Dalton Dalton NNP cord-001273-plz1ja2e 84 3 et et NNP cord-001273-plz1ja2e 84 4 al al NNP cord-001273-plz1ja2e 84 5 . . NNP cord-001273-plz1ja2e 84 6 , , , cord-001273-plz1ja2e 84 7 1993 1993 CD cord-001273-plz1ja2e 84 8 ; ; : cord-001273-plz1ja2e 85 1 Kamijo Kamijo NNP cord-001273-plz1ja2e 85 2 et et NNP cord-001273-plz1ja2e 85 3 al al NNP cord-001273-plz1ja2e 85 4 . . NNP cord-001273-plz1ja2e 85 5 , , , cord-001273-plz1ja2e 85 6 1993 1993 CD cord-001273-plz1ja2e 85 7 ) ) -RRB- cord-001273-plz1ja2e 85 8 . . . cord-001273-plz1ja2e 86 1 Genetic genetic JJ cord-001273-plz1ja2e 86 2 deficiencies deficiency NNS cord-001273-plz1ja2e 86 3 resulting result VBG cord-001273-plz1ja2e 86 4 in in IN cord-001273-plz1ja2e 86 5 the the DT cord-001273-plz1ja2e 86 6 loss loss NN cord-001273-plz1ja2e 86 7 of of IN cord-001273-plz1ja2e 86 8 IFN IFN NNP cord-001273-plz1ja2e 86 9 - - HYPH cord-001273-plz1ja2e 86 10 γ γ NN cord-001273-plz1ja2e 86 11 production production NN cord-001273-plz1ja2e 86 12 or or CC cord-001273-plz1ja2e 86 13 signaling signal VBG cord-001273-plz1ja2e 86 14 in in IN cord-001273-plz1ja2e 86 15 mice mouse NNS cord-001273-plz1ja2e 86 16 lead lead VBP cord-001273-plz1ja2e 86 17 to to IN cord-001273-plz1ja2e 86 18 increased increase VBN cord-001273-plz1ja2e 86 19 susceptibility susceptibility NN cord-001273-plz1ja2e 86 20 to to IN cord-001273-plz1ja2e 86 21 infections infection NNS cord-001273-plz1ja2e 86 22 by by IN cord-001273-plz1ja2e 86 23 other other JJ cord-001273-plz1ja2e 86 24 intracellular intracellular JJ cord-001273-plz1ja2e 86 25 pathogens pathogen NNS cord-001273-plz1ja2e 86 26 , , , cord-001273-plz1ja2e 86 27 such such JJ cord-001273-plz1ja2e 86 28 as as IN cord-001273-plz1ja2e 86 29 L. L. NNP cord-001273-plz1ja2e 86 30 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 86 31 ( ( -LRB- cord-001273-plz1ja2e 86 32 see see VB cord-001273-plz1ja2e 86 33 below below RB cord-001273-plz1ja2e 86 34 ) ) -RRB- cord-001273-plz1ja2e 86 35 , , , cord-001273-plz1ja2e 86 36 Salmonella Salmonella NNP cord-001273-plz1ja2e 86 37 typhimurium typhimurium NN cord-001273-plz1ja2e 86 38 and and CC cord-001273-plz1ja2e 86 39 some some DT cord-001273-plz1ja2e 86 40 viruses virus NNS cord-001273-plz1ja2e 86 41 Harty Harty NNP cord-001273-plz1ja2e 86 42 and and CC cord-001273-plz1ja2e 86 43 Bevan Bevan NNP cord-001273-plz1ja2e 86 44 , , , cord-001273-plz1ja2e 86 45 1995 1995 CD cord-001273-plz1ja2e 86 46 ; ; : cord-001273-plz1ja2e 87 1 Jouanguy Jouanguy NNP cord-001273-plz1ja2e 87 2 et et NNP cord-001273-plz1ja2e 87 3 al al NNP cord-001273-plz1ja2e 87 4 . . NNP cord-001273-plz1ja2e 87 5 , , , cord-001273-plz1ja2e 87 6 1999 1999 CD cord-001273-plz1ja2e 87 7 ) ) -RRB- cord-001273-plz1ja2e 87 8 . . . cord-001273-plz1ja2e 88 1 These these DT cord-001273-plz1ja2e 88 2 defects defect NNS cord-001273-plz1ja2e 88 3 also also RB cord-001273-plz1ja2e 88 4 lead lead VBP cord-001273-plz1ja2e 88 5 to to IN cord-001273-plz1ja2e 88 6 the the DT cord-001273-plz1ja2e 88 7 loss loss NN cord-001273-plz1ja2e 88 8 of of IN cord-001273-plz1ja2e 88 9 tumor tumor NN cord-001273-plz1ja2e 88 10 control control NN cord-001273-plz1ja2e 89 1 ( ( -LRB- cord-001273-plz1ja2e 89 2 Kaplan Kaplan NNP cord-001273-plz1ja2e 89 3 et et NNP cord-001273-plz1ja2e 89 4 al al NNP cord-001273-plz1ja2e 89 5 . . NNP cord-001273-plz1ja2e 89 6 , , , cord-001273-plz1ja2e 89 7 1998 1998 CD cord-001273-plz1ja2e 89 8 ) ) -RRB- cord-001273-plz1ja2e 89 9 . . . cord-001273-plz1ja2e 90 1 Patients patient NNS cord-001273-plz1ja2e 90 2 with with IN cord-001273-plz1ja2e 90 3 deficiencies deficiency NNS cord-001273-plz1ja2e 90 4 in in IN cord-001273-plz1ja2e 90 5 the the DT cord-001273-plz1ja2e 90 6 IFN IFN NNP cord-001273-plz1ja2e 90 7 - - HYPH cord-001273-plz1ja2e 90 8 γ γ NNP cord-001273-plz1ja2e 90 9 pathway pathway NN cord-001273-plz1ja2e 90 10 , , , cord-001273-plz1ja2e 90 11 for for IN cord-001273-plz1ja2e 90 12 instance instance NN cord-001273-plz1ja2e 90 13 by by IN cord-001273-plz1ja2e 90 14 mutation mutation NN cord-001273-plz1ja2e 90 15 in in IN cord-001273-plz1ja2e 90 16 the the DT cord-001273-plz1ja2e 90 17 gene gene NN cord-001273-plz1ja2e 90 18 for for IN cord-001273-plz1ja2e 90 19 the the DT cord-001273-plz1ja2e 90 20 IFN IFN NNP cord-001273-plz1ja2e 90 21 - - HYPH cord-001273-plz1ja2e 90 22 γ γ NNP cord-001273-plz1ja2e 90 23 receptor receptor NN cord-001273-plz1ja2e 90 24 1 1 CD cord-001273-plz1ja2e 90 25 , , , cord-001273-plz1ja2e 90 26 are be VBP cord-001273-plz1ja2e 90 27 characterized characterize VBN cord-001273-plz1ja2e 90 28 by by IN cord-001273-plz1ja2e 90 29 severe severe JJ cord-001273-plz1ja2e 90 30 infections infection NNS cord-001273-plz1ja2e 90 31 with with IN cord-001273-plz1ja2e 90 32 viruses virus NNS cord-001273-plz1ja2e 90 33 and and CC cord-001273-plz1ja2e 90 34 intracellular intracellular JJ cord-001273-plz1ja2e 90 35 bacteria bacteria NNS cord-001273-plz1ja2e 90 36 including include VBG cord-001273-plz1ja2e 90 37 L. L. NNP cord-001273-plz1ja2e 90 38 monocytogenes monocytogene NNS cord-001273-plz1ja2e 90 39 , , , cord-001273-plz1ja2e 90 40 Salmonella Salmonella NNP cord-001273-plz1ja2e 90 41 sp sp NN cord-001273-plz1ja2e 90 42 . . . cord-001273-plz1ja2e 91 1 and and CC cord-001273-plz1ja2e 91 2 mycobacteria mycobacterium NNS cord-001273-plz1ja2e 92 1 ( ( -LRB- cord-001273-plz1ja2e 92 2 Jouanguy Jouanguy NNP cord-001273-plz1ja2e 92 3 et et NNP cord-001273-plz1ja2e 92 4 al al NNP cord-001273-plz1ja2e 92 5 . . . cord-001273-plz1ja2e 93 1 , , , cord-001273-plz1ja2e 93 2 1996 1996 CD cord-001273-plz1ja2e 93 3 ; ; : cord-001273-plz1ja2e 93 4 Newport Newport NNP cord-001273-plz1ja2e 93 5 et et NNP cord-001273-plz1ja2e 93 6 al al NNP cord-001273-plz1ja2e 93 7 . . . cord-001273-plz1ja2e 94 1 , , , cord-001273-plz1ja2e 94 2 1996 1996 CD cord-001273-plz1ja2e 94 3 ; ; : cord-001273-plz1ja2e 94 4 Roesler Roesler NNP cord-001273-plz1ja2e 94 5 et et NNP cord-001273-plz1ja2e 94 6 al al NNP cord-001273-plz1ja2e 94 7 . . NNP cord-001273-plz1ja2e 94 8 , , , cord-001273-plz1ja2e 94 9 1999 1999 CD cord-001273-plz1ja2e 94 10 ; ; : cord-001273-plz1ja2e 94 11 van van NNP cord-001273-plz1ja2e 94 12 de de NNP cord-001273-plz1ja2e 94 13 Vosse Vosse NNP cord-001273-plz1ja2e 94 14 et et NNP cord-001273-plz1ja2e 94 15 al al NNP cord-001273-plz1ja2e 94 16 . . NNP cord-001273-plz1ja2e 94 17 , , , cord-001273-plz1ja2e 94 18 2009 2009 CD cord-001273-plz1ja2e 94 19 ) ) -RRB- cord-001273-plz1ja2e 94 20 . . . cord-001273-plz1ja2e 95 1 IFN IFN NNP cord-001273-plz1ja2e 95 2 - - HYPH cord-001273-plz1ja2e 95 3 γ γ NNP cord-001273-plz1ja2e 95 4 mediates mediate VBZ cord-001273-plz1ja2e 95 5 macrophage macrophage NN cord-001273-plz1ja2e 95 6 activation activation NN cord-001273-plz1ja2e 95 7 , , , cord-001273-plz1ja2e 95 8 i.e. i.e. FW cord-001273-plz1ja2e 95 9 , , , cord-001273-plz1ja2e 95 10 increased increase VBN cord-001273-plz1ja2e 95 11 phagocytosis phagocytosis NN cord-001273-plz1ja2e 95 12 and and CC cord-001273-plz1ja2e 95 13 production production NN cord-001273-plz1ja2e 95 14 of of IN cord-001273-plz1ja2e 95 15 pro pro JJ cord-001273-plz1ja2e 95 16 - - JJ cord-001273-plz1ja2e 95 17 inflammatory inflammatory JJ cord-001273-plz1ja2e 95 18 cytokines cytokine NNS cord-001273-plz1ja2e 95 19 , , , cord-001273-plz1ja2e 95 20 of of IN cord-001273-plz1ja2e 95 21 microbicidal microbicidal JJ cord-001273-plz1ja2e 95 22 reactive reactive JJ cord-001273-plz1ja2e 95 23 oxygen oxygen NN cord-001273-plz1ja2e 95 24 and and CC cord-001273-plz1ja2e 95 25 nitrogen nitrogen NN cord-001273-plz1ja2e 95 26 species specie NNS cord-001273-plz1ja2e 95 27 , , , cord-001273-plz1ja2e 95 28 leading lead VBG cord-001273-plz1ja2e 95 29 to to IN cord-001273-plz1ja2e 95 30 clearance clearance NN cord-001273-plz1ja2e 95 31 of of IN cord-001273-plz1ja2e 95 32 intracellular intracellular JJ cord-001273-plz1ja2e 95 33 pathogens pathogen NNS cord-001273-plz1ja2e 95 34 ( ( -LRB- cord-001273-plz1ja2e 95 35 Schoenborn Schoenborn NNP cord-001273-plz1ja2e 95 36 and and CC cord-001273-plz1ja2e 95 37 Wilson Wilson NNP cord-001273-plz1ja2e 95 38 , , , cord-001273-plz1ja2e 95 39 2007 2007 CD cord-001273-plz1ja2e 95 40 ) ) -RRB- cord-001273-plz1ja2e 95 41 . . . cord-001273-plz1ja2e 96 1 In in IN cord-001273-plz1ja2e 96 2 addition addition NN cord-001273-plz1ja2e 96 3 , , , cord-001273-plz1ja2e 96 4 IFN IFN NNP cord-001273-plz1ja2e 96 5 - - HYPH cord-001273-plz1ja2e 96 6 γ γ NNP cord-001273-plz1ja2e 96 7 controls control VBZ cord-001273-plz1ja2e 96 8 differentiation differentiation NN cord-001273-plz1ja2e 96 9 of of IN cord-001273-plz1ja2e 96 10 T t NN cord-001273-plz1ja2e 96 11 cells cell NNS cord-001273-plz1ja2e 96 12 in in IN cord-001273-plz1ja2e 96 13 Th1 th1 NN cord-001273-plz1ja2e 96 14 effector effector NN cord-001273-plz1ja2e 96 15 cells cell NNS cord-001273-plz1ja2e 96 16 , , , cord-001273-plz1ja2e 96 17 antigen antigen NN cord-001273-plz1ja2e 96 18 processing processing NN cord-001273-plz1ja2e 96 19 and and CC cord-001273-plz1ja2e 96 20 presentation presentation NN cord-001273-plz1ja2e 96 21 by by IN cord-001273-plz1ja2e 96 22 antigen antigen NN cord-001273-plz1ja2e 96 23 - - HYPH cord-001273-plz1ja2e 96 24 presenting present VBG cord-001273-plz1ja2e 96 25 cells cell NNS cord-001273-plz1ja2e 96 26 , , , cord-001273-plz1ja2e 96 27 which which WDT cord-001273-plz1ja2e 96 28 participate participate VBP cord-001273-plz1ja2e 96 29 to to IN cord-001273-plz1ja2e 96 30 cellular cellular JJ cord-001273-plz1ja2e 96 31 immunity immunity NN cord-001273-plz1ja2e 96 32 against against IN cord-001273-plz1ja2e 96 33 intracellular intracellular JJ cord-001273-plz1ja2e 96 34 pathogens pathogen NNS cord-001273-plz1ja2e 96 35 ( ( -LRB- cord-001273-plz1ja2e 96 36 Schroder Schroder NNP cord-001273-plz1ja2e 96 37 , , , cord-001273-plz1ja2e 96 38 2003 2003 CD cord-001273-plz1ja2e 96 39 ; ; : cord-001273-plz1ja2e 96 40 Hu Hu NNP cord-001273-plz1ja2e 96 41 and and CC cord-001273-plz1ja2e 96 42 Ivashkiv Ivashkiv NNP cord-001273-plz1ja2e 96 43 , , , cord-001273-plz1ja2e 96 44 2009 2009 CD cord-001273-plz1ja2e 96 45 ) ) -RRB- cord-001273-plz1ja2e 96 46 . . . cord-001273-plz1ja2e 97 1 The the DT cord-001273-plz1ja2e 97 2 immunostimulatory immunostimulatory NN cord-001273-plz1ja2e 97 3 and and CC cord-001273-plz1ja2e 97 4 immunomodulatory immunomodulatory JJ cord-001273-plz1ja2e 97 5 properties property NNS cord-001273-plz1ja2e 97 6 of of IN cord-001273-plz1ja2e 97 7 IFN IFN NNP cord-001273-plz1ja2e 97 8 - - HYPH cord-001273-plz1ja2e 97 9 γ γ NNP cord-001273-plz1ja2e 97 10 have have VBP cord-001273-plz1ja2e 97 11 therapeutic therapeutic JJ cord-001273-plz1ja2e 97 12 implications implication NNS cord-001273-plz1ja2e 97 13 . . . cord-001273-plz1ja2e 98 1 Indeed indeed RB cord-001273-plz1ja2e 98 2 , , , cord-001273-plz1ja2e 98 3 IFN IFN NNP cord-001273-plz1ja2e 98 4 - - HYPH cord-001273-plz1ja2e 98 5 γ γ NNP cord-001273-plz1ja2e 98 6 is be VBZ cord-001273-plz1ja2e 98 7 used use VBN cord-001273-plz1ja2e 98 8 in in IN cord-001273-plz1ja2e 98 9 patients patient NNS cord-001273-plz1ja2e 98 10 with with IN cord-001273-plz1ja2e 98 11 chronic chronic JJ cord-001273-plz1ja2e 98 12 granulomatous granulomatous JJ cord-001273-plz1ja2e 98 13 disease disease NN cord-001273-plz1ja2e 98 14 to to TO cord-001273-plz1ja2e 98 15 reduce reduce VB cord-001273-plz1ja2e 98 16 infection infection NN cord-001273-plz1ja2e 98 17 and and CC cord-001273-plz1ja2e 98 18 mortality mortality NN cord-001273-plz1ja2e 98 19 , , , cord-001273-plz1ja2e 98 20 _SP cord-001273-plz1ja2e 99 1 * * NFP cord-001273-plz1ja2e 99 2 * * NFP cord-001273-plz1ja2e 99 3 Protein protein NN cord-001273-plz1ja2e 99 4 length length NN cord-001273-plz1ja2e 99 5 in in IN cord-001273-plz1ja2e 99 6 amino amino NN cord-001273-plz1ja2e 99 7 - - HYPH cord-001273-plz1ja2e 99 8 acids acid NNS cord-001273-plz1ja2e 99 9 and and CC cord-001273-plz1ja2e 99 10 protein protein NN cord-001273-plz1ja2e 99 11 modifications modification NNS cord-001273-plz1ja2e 99 12 ( ( -LRB- cord-001273-plz1ja2e 99 13 G g NN cord-001273-plz1ja2e 99 14 : : : cord-001273-plz1ja2e 99 15 glycosylation glycosylation NN cord-001273-plz1ja2e 99 16 , , , cord-001273-plz1ja2e 99 17 P p NN cord-001273-plz1ja2e 99 18 : : : cord-001273-plz1ja2e 99 19 phosphorylation phosphorylation NN cord-001273-plz1ja2e 99 20 ) ) -RRB- cord-001273-plz1ja2e 99 21 . . . cord-001273-plz1ja2e 100 1 * * NFP cord-001273-plz1ja2e 100 2 * * NFP cord-001273-plz1ja2e 100 3 * * NFP cord-001273-plz1ja2e 100 4 13 13 CD cord-001273-plz1ja2e 100 5 genes gene NNS cord-001273-plz1ja2e 100 6 and and CC cord-001273-plz1ja2e 100 7 a a DT cord-001273-plz1ja2e 100 8 pseudogene pseudogene NN cord-001273-plz1ja2e 100 9 in in IN cord-001273-plz1ja2e 100 10 the the DT cord-001273-plz1ja2e 100 11 human human JJ cord-001273-plz1ja2e 100 12 genome genome NN cord-001273-plz1ja2e 100 13 , , , cord-001273-plz1ja2e 100 14 14 14 CD cord-001273-plz1ja2e 100 15 genes gene NNS cord-001273-plz1ja2e 100 16 and and CC cord-001273-plz1ja2e 100 17 three three CD cord-001273-plz1ja2e 100 18 pseudogenes pseudogene NNS cord-001273-plz1ja2e 100 19 in in IN cord-001273-plz1ja2e 100 20 the the DT cord-001273-plz1ja2e 100 21 mouse mouse NN cord-001273-plz1ja2e 100 22 genome genome NN cord-001273-plz1ja2e 100 23 . . . cord-001273-plz1ja2e 101 1 although although IN cord-001273-plz1ja2e 101 2 the the DT cord-001273-plz1ja2e 101 3 clinical clinical JJ cord-001273-plz1ja2e 101 4 benefit benefit NN cord-001273-plz1ja2e 101 5 has have VBZ cord-001273-plz1ja2e 101 6 not not RB cord-001273-plz1ja2e 101 7 been be VBN cord-001273-plz1ja2e 101 8 demonstrated demonstrate VBN cord-001273-plz1ja2e 101 9 in in IN cord-001273-plz1ja2e 101 10 all all DT cord-001273-plz1ja2e 101 11 studies study NNS cord-001273-plz1ja2e 101 12 ( ( -LRB- cord-001273-plz1ja2e 101 13 Holland Holland NNP cord-001273-plz1ja2e 101 14 , , , cord-001273-plz1ja2e 101 15 2010 2010 CD cord-001273-plz1ja2e 101 16 ) ) -RRB- cord-001273-plz1ja2e 101 17 . . . cord-001273-plz1ja2e 102 1 Type Type NNP cord-001273-plz1ja2e 102 2 I i NN cord-001273-plz1ja2e 102 3 - - HYPH cord-001273-plz1ja2e 102 4 IFNs IFNs NNP cord-001273-plz1ja2e 102 5 are be VBP cord-001273-plz1ja2e 102 6 produced produce VBN cord-001273-plz1ja2e 102 7 in in IN cord-001273-plz1ja2e 102 8 responses response NNS cord-001273-plz1ja2e 102 9 to to IN cord-001273-plz1ja2e 102 10 viruses virus NNS cord-001273-plz1ja2e 102 11 , , , cord-001273-plz1ja2e 102 12 many many JJ cord-001273-plz1ja2e 102 13 bacteria bacteria NNS cord-001273-plz1ja2e 102 14 and and CC cord-001273-plz1ja2e 102 15 parasites parasite NNS cord-001273-plz1ja2e 102 16 . . . cord-001273-plz1ja2e 103 1 However however RB cord-001273-plz1ja2e 103 2 , , , cord-001273-plz1ja2e 103 3 in in IN cord-001273-plz1ja2e 103 4 contrast contrast NN cord-001273-plz1ja2e 103 5 to to IN cord-001273-plz1ja2e 103 6 type type NN cord-001273-plz1ja2e 103 7 II II NNP cord-001273-plz1ja2e 103 8 IFNs ifn NNS cord-001273-plz1ja2e 103 9 , , , cord-001273-plz1ja2e 103 10 these these DT cord-001273-plz1ja2e 103 11 cytokines cytokine NNS cord-001273-plz1ja2e 103 12 are be VBP cord-001273-plz1ja2e 103 13 not not RB cord-001273-plz1ja2e 103 14 always always RB cord-001273-plz1ja2e 103 15 protective protective JJ cord-001273-plz1ja2e 103 16 against against IN cord-001273-plz1ja2e 103 17 bacterial bacterial JJ cord-001273-plz1ja2e 103 18 infections infection NNS cord-001273-plz1ja2e 103 19 . . . cord-001273-plz1ja2e 104 1 Indeed indeed RB cord-001273-plz1ja2e 104 2 , , , cord-001273-plz1ja2e 104 3 the the DT cord-001273-plz1ja2e 104 4 role role NN cord-001273-plz1ja2e 104 5 of of IN cord-001273-plz1ja2e 104 6 type type NN cord-001273-plz1ja2e 104 7 I I NNP cord-001273-plz1ja2e 104 8 - - HYPH cord-001273-plz1ja2e 104 9 IFNs IFNs NNP cord-001273-plz1ja2e 104 10 in in IN cord-001273-plz1ja2e 104 11 response response NN cord-001273-plz1ja2e 104 12 to to IN cord-001273-plz1ja2e 104 13 bacterial bacterial JJ cord-001273-plz1ja2e 104 14 infection infection NN cord-001273-plz1ja2e 104 15 is be VBZ cord-001273-plz1ja2e 104 16 complex complex JJ cord-001273-plz1ja2e 104 17 and and CC cord-001273-plz1ja2e 104 18 depends depend VBZ cord-001273-plz1ja2e 104 19 on on IN cord-001273-plz1ja2e 104 20 the the DT cord-001273-plz1ja2e 104 21 microorganism microorganism NN cord-001273-plz1ja2e 104 22 ( ( -LRB- cord-001273-plz1ja2e 104 23 Decker Decker NNP cord-001273-plz1ja2e 104 24 et et NNP cord-001273-plz1ja2e 104 25 al al NNP cord-001273-plz1ja2e 104 26 . . NNP cord-001273-plz1ja2e 104 27 , , , cord-001273-plz1ja2e 104 28 2005 2005 CD cord-001273-plz1ja2e 104 29 ; ; : cord-001273-plz1ja2e 104 30 Monroe Monroe NNP cord-001273-plz1ja2e 104 31 et et NNP cord-001273-plz1ja2e 104 32 al al NNP cord-001273-plz1ja2e 104 33 . . NNP cord-001273-plz1ja2e 104 34 , , , cord-001273-plz1ja2e 104 35 2010 2010 CD cord-001273-plz1ja2e 104 36 ; ; : cord-001273-plz1ja2e 104 37 Carrero Carrero NNP cord-001273-plz1ja2e 104 38 , , , cord-001273-plz1ja2e 104 39 2013 2013 CD cord-001273-plz1ja2e 104 40 ) ) -RRB- cord-001273-plz1ja2e 104 41 . . . cord-001273-plz1ja2e 105 1 They -PRON- PRP cord-001273-plz1ja2e 105 2 contribute contribute VBP cord-001273-plz1ja2e 105 3 to to IN cord-001273-plz1ja2e 105 4 resistance resistance NN cord-001273-plz1ja2e 105 5 of of IN cord-001273-plz1ja2e 105 6 the the DT cord-001273-plz1ja2e 105 7 host host NN cord-001273-plz1ja2e 105 8 against against IN cord-001273-plz1ja2e 105 9 infection infection NN cord-001273-plz1ja2e 105 10 by by IN cord-001273-plz1ja2e 105 11 extracellular extracellular JJ cord-001273-plz1ja2e 105 12 bacteria bacteria NNS cord-001273-plz1ja2e 105 13 , , , cord-001273-plz1ja2e 105 14 such such JJ cord-001273-plz1ja2e 105 15 as as IN cord-001273-plz1ja2e 105 16 Escherichia Escherichia NNP cord-001273-plz1ja2e 105 17 coli coli NNS cord-001273-plz1ja2e 105 18 , , , cord-001273-plz1ja2e 105 19 Helicobacter helicobacter NN cord-001273-plz1ja2e 105 20 pylori pylori NN cord-001273-plz1ja2e 105 21 , , , cord-001273-plz1ja2e 105 22 Streptococcus Streptococcus NNP cord-001273-plz1ja2e 105 23 agalactiae agalactiae NN cord-001273-plz1ja2e 105 24 and and CC cord-001273-plz1ja2e 105 25 S. S. NNP cord-001273-plz1ja2e 105 26 pneumoniae pneumoniae NN cord-001273-plz1ja2e 105 27 ( ( -LRB- cord-001273-plz1ja2e 105 28 Mancuso Mancuso NNP cord-001273-plz1ja2e 105 29 et et NNP cord-001273-plz1ja2e 105 30 al al NNP cord-001273-plz1ja2e 105 31 . . NNP cord-001273-plz1ja2e 105 32 , , , cord-001273-plz1ja2e 105 33 2007 2007 CD cord-001273-plz1ja2e 105 34 ; ; . cord-001273-plz1ja2e 106 1 Watanabe Watanabe NNP cord-001273-plz1ja2e 106 2 et et NNP cord-001273-plz1ja2e 106 3 al al NNP cord-001273-plz1ja2e 106 4 . . NNP cord-001273-plz1ja2e 106 5 , , , cord-001273-plz1ja2e 106 6 2010 2010 CD cord-001273-plz1ja2e 106 7 ) ) -RRB- cord-001273-plz1ja2e 106 8 . . . cord-001273-plz1ja2e 107 1 In in IN cord-001273-plz1ja2e 107 2 contrast contrast NN cord-001273-plz1ja2e 107 3 , , , cord-001273-plz1ja2e 107 4 they -PRON- PRP cord-001273-plz1ja2e 107 5 are be VBP cord-001273-plz1ja2e 107 6 associated associate VBN cord-001273-plz1ja2e 107 7 with with IN cord-001273-plz1ja2e 107 8 suppression suppression NN cord-001273-plz1ja2e 107 9 of of IN cord-001273-plz1ja2e 107 10 innate innate JJ cord-001273-plz1ja2e 107 11 immune immune JJ cord-001273-plz1ja2e 107 12 responses response NNS cord-001273-plz1ja2e 107 13 and and CC cord-001273-plz1ja2e 107 14 increased increase VBN cord-001273-plz1ja2e 107 15 susceptibility susceptibility NN cord-001273-plz1ja2e 107 16 of of IN cord-001273-plz1ja2e 107 17 the the DT cord-001273-plz1ja2e 107 18 host host NN cord-001273-plz1ja2e 107 19 to to IN cord-001273-plz1ja2e 107 20 infection infection NN cord-001273-plz1ja2e 107 21 by by IN cord-001273-plz1ja2e 107 22 L. L. NNP cord-001273-plz1ja2e 107 23 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 107 24 ( ( -LRB- cord-001273-plz1ja2e 107 25 see see VB cord-001273-plz1ja2e 107 26 below below RB cord-001273-plz1ja2e 107 27 ) ) -RRB- cord-001273-plz1ja2e 107 28 , , , cord-001273-plz1ja2e 107 29 Brucella Brucella NNP cord-001273-plz1ja2e 107 30 abortus abortus NN cord-001273-plz1ja2e 107 31 , , , cord-001273-plz1ja2e 107 32 Chlamydia Chlamydia NNP cord-001273-plz1ja2e 107 33 muridarum muridarum NN cord-001273-plz1ja2e 107 34 , , , cord-001273-plz1ja2e 107 35 Francisella Francisella NNP cord-001273-plz1ja2e 107 36 novicida novicida NN cord-001273-plz1ja2e 107 37 , , , cord-001273-plz1ja2e 107 38 Salmonella Salmonella NNP cord-001273-plz1ja2e 107 39 enterica enterica NN cord-001273-plz1ja2e 107 40 , , , cord-001273-plz1ja2e 107 41 Staphylococcus Staphylococcus NNP cord-001273-plz1ja2e 107 42 aureus aureus NN cord-001273-plz1ja2e 107 43 , , , cord-001273-plz1ja2e 107 44 and and CC cord-001273-plz1ja2e 107 45 Yersinia Yersinia NNP cord-001273-plz1ja2e 107 46 pestis pestis NNP cord-001273-plz1ja2e 108 1 ( ( -LRB- cord-001273-plz1ja2e 108 2 Auerbuch Auerbuch NNP cord-001273-plz1ja2e 108 3 et et NNP cord-001273-plz1ja2e 108 4 al al NNP cord-001273-plz1ja2e 108 5 . . NNP cord-001273-plz1ja2e 108 6 , , , cord-001273-plz1ja2e 108 7 2004 2004 CD cord-001273-plz1ja2e 109 1 ; ; : cord-001273-plz1ja2e 109 2 Carrero Carrero NNP cord-001273-plz1ja2e 109 3 et et NNP cord-001273-plz1ja2e 109 4 al al NNP cord-001273-plz1ja2e 109 5 . . NNP cord-001273-plz1ja2e 109 6 , , , cord-001273-plz1ja2e 109 7 2004 2004 CD cord-001273-plz1ja2e 109 8 ; ; : cord-001273-plz1ja2e 109 9 O'Connell O'Connell NNP cord-001273-plz1ja2e 109 10 et et NNP cord-001273-plz1ja2e 109 11 al al NNP cord-001273-plz1ja2e 109 12 . . NNP cord-001273-plz1ja2e 109 13 , , , cord-001273-plz1ja2e 109 14 2004 2004 CD cord-001273-plz1ja2e 110 1 ; ; : cord-001273-plz1ja2e 110 2 Qiu Qiu NNP cord-001273-plz1ja2e 110 3 et et FW cord-001273-plz1ja2e 110 4 al al NNP cord-001273-plz1ja2e 110 5 . . NNP cord-001273-plz1ja2e 110 6 , , , cord-001273-plz1ja2e 110 7 2008 2008 CD cord-001273-plz1ja2e 110 8 ; ; : cord-001273-plz1ja2e 110 9 Martin Martin NNP cord-001273-plz1ja2e 110 10 et et NNP cord-001273-plz1ja2e 110 11 al al NNP cord-001273-plz1ja2e 110 12 . . NNP cord-001273-plz1ja2e 110 13 , , , cord-001273-plz1ja2e 110 14 2009 2009 CD cord-001273-plz1ja2e 110 15 ; ; : cord-001273-plz1ja2e 110 16 Henry Henry NNP cord-001273-plz1ja2e 110 17 et et NNP cord-001273-plz1ja2e 110 18 al al NNP cord-001273-plz1ja2e 110 19 . . NNP cord-001273-plz1ja2e 110 20 , , , cord-001273-plz1ja2e 110 21 2010 2010 CD cord-001273-plz1ja2e 110 22 ; ; : cord-001273-plz1ja2e 110 23 de de NNP cord-001273-plz1ja2e 110 24 Almeida Almeida NNP cord-001273-plz1ja2e 110 25 et et NNP cord-001273-plz1ja2e 110 26 al al NNP cord-001273-plz1ja2e 110 27 . . NNP cord-001273-plz1ja2e 110 28 , , , cord-001273-plz1ja2e 110 29 2011 2011 CD cord-001273-plz1ja2e 110 30 ; ; : cord-001273-plz1ja2e 110 31 Patel Patel NNP cord-001273-plz1ja2e 110 32 et et NNP cord-001273-plz1ja2e 110 33 al al NNP cord-001273-plz1ja2e 110 34 . . NNP cord-001273-plz1ja2e 110 35 , , , cord-001273-plz1ja2e 110 36 2012 2012 CD cord-001273-plz1ja2e 110 37 ; ; : cord-001273-plz1ja2e 110 38 Robinson Robinson NNP cord-001273-plz1ja2e 110 39 et et NNP cord-001273-plz1ja2e 110 40 al al NNP cord-001273-plz1ja2e 110 41 . . . cord-001273-plz1ja2e 111 1 , , , cord-001273-plz1ja2e 111 2 2012 2012 CD cord-001273-plz1ja2e 111 3 ; ; : cord-001273-plz1ja2e 111 4 Archer Archer NNP cord-001273-plz1ja2e 111 5 et et NNP cord-001273-plz1ja2e 111 6 al al NNP cord-001273-plz1ja2e 111 7 . . . cord-001273-plz1ja2e 112 1 , , , cord-001273-plz1ja2e 112 2 2014 2014 CD cord-001273-plz1ja2e 112 3 ) ) -RRB- cord-001273-plz1ja2e 112 4 . . . cord-001273-plz1ja2e 113 1 These these DT cord-001273-plz1ja2e 113 2 different different JJ cord-001273-plz1ja2e 113 3 effects effect NNS cord-001273-plz1ja2e 113 4 on on IN cord-001273-plz1ja2e 113 5 infection infection NN cord-001273-plz1ja2e 113 6 are be VBP cord-001273-plz1ja2e 113 7 likely likely RB cord-001273-plz1ja2e 113 8 linked link VBN cord-001273-plz1ja2e 113 9 to to IN cord-001273-plz1ja2e 113 10 the the DT cord-001273-plz1ja2e 113 11 wide wide JJ cord-001273-plz1ja2e 113 12 range range NN cord-001273-plz1ja2e 113 13 of of IN cord-001273-plz1ja2e 113 14 cellular cellular JJ cord-001273-plz1ja2e 113 15 responses response NNS cord-001273-plz1ja2e 113 16 induced induce VBN cord-001273-plz1ja2e 113 17 by by IN cord-001273-plz1ja2e 113 18 their -PRON- PRP$ cord-001273-plz1ja2e 113 19 downstream downstream JJ cord-001273-plz1ja2e 113 20 effectors effector NNS cord-001273-plz1ja2e 113 21 , , , cord-001273-plz1ja2e 113 22 the the DT cord-001273-plz1ja2e 113 23 products product NNS cord-001273-plz1ja2e 113 24 of of IN cord-001273-plz1ja2e 113 25 IFN IFN NNP cord-001273-plz1ja2e 113 26 - - HYPH cord-001273-plz1ja2e 113 27 stimulated stimulate VBN cord-001273-plz1ja2e 113 28 genes gene NNS cord-001273-plz1ja2e 113 29 ( ( -LRB- cord-001273-plz1ja2e 113 30 ISGs ISGs NNP cord-001273-plz1ja2e 113 31 ) ) -RRB- cord-001273-plz1ja2e 114 1 ( ( -LRB- cord-001273-plz1ja2e 114 2 Schoggins Schoggins NNP cord-001273-plz1ja2e 114 3 et et NNP cord-001273-plz1ja2e 114 4 al al NNP cord-001273-plz1ja2e 114 5 . . NNP cord-001273-plz1ja2e 114 6 , , , cord-001273-plz1ja2e 114 7 2011 2011 CD cord-001273-plz1ja2e 114 8 ) ) -RRB- cord-001273-plz1ja2e 114 9 . . . cord-001273-plz1ja2e 115 1 Although although IN cord-001273-plz1ja2e 115 2 Type Type NNP cord-001273-plz1ja2e 115 3 I i NN cord-001273-plz1ja2e 115 4 - - HYPH cord-001273-plz1ja2e 115 5 IFNs IFNs NNP cord-001273-plz1ja2e 115 6 have have VBP cord-001273-plz1ja2e 115 7 long long RB cord-001273-plz1ja2e 115 8 been be VBN cord-001273-plz1ja2e 115 9 known know VBN cord-001273-plz1ja2e 115 10 to to TO cord-001273-plz1ja2e 115 11 induce induce VB cord-001273-plz1ja2e 115 12 antiviral antiviral JJ cord-001273-plz1ja2e 115 13 response response NN cord-001273-plz1ja2e 115 14 in in IN cord-001273-plz1ja2e 115 15 the the DT cord-001273-plz1ja2e 115 16 infected infected JJ cord-001273-plz1ja2e 115 17 host host NN cord-001273-plz1ja2e 115 18 ( ( -LRB- cord-001273-plz1ja2e 115 19 Isaacs Isaacs NNP cord-001273-plz1ja2e 115 20 and and CC cord-001273-plz1ja2e 115 21 Lindemann Lindemann NNP cord-001273-plz1ja2e 115 22 , , , cord-001273-plz1ja2e 115 23 1957 1957 CD cord-001273-plz1ja2e 115 24 ) ) -RRB- cord-001273-plz1ja2e 115 25 , , , cord-001273-plz1ja2e 115 26 they -PRON- PRP cord-001273-plz1ja2e 115 27 can can MD cord-001273-plz1ja2e 115 28 also also RB cord-001273-plz1ja2e 115 29 induce induce VB cord-001273-plz1ja2e 115 30 apoptosis apoptosis NN cord-001273-plz1ja2e 115 31 , , , cord-001273-plz1ja2e 115 32 autophagy autophagy NN cord-001273-plz1ja2e 115 33 , , , cord-001273-plz1ja2e 115 34 differentiation differentiation NN cord-001273-plz1ja2e 115 35 and and CC cord-001273-plz1ja2e 115 36 migration migration NN cord-001273-plz1ja2e 115 37 , , , cord-001273-plz1ja2e 115 38 inhibit inhibit VBP cord-001273-plz1ja2e 115 39 proliferation proliferation NN cord-001273-plz1ja2e 115 40 as as RB cord-001273-plz1ja2e 115 41 well well RB cord-001273-plz1ja2e 115 42 as as IN cord-001273-plz1ja2e 115 43 angiogenesis angiogenesis NN cord-001273-plz1ja2e 115 44 and and CC cord-001273-plz1ja2e 115 45 mediate mediate VB cord-001273-plz1ja2e 115 46 cellular cellular JJ cord-001273-plz1ja2e 115 47 damage damage NN cord-001273-plz1ja2e 115 48 , , , cord-001273-plz1ja2e 115 49 inflammation inflammation NN cord-001273-plz1ja2e 115 50 or or CC cord-001273-plz1ja2e 115 51 autoimmunity autoimmunity NN cord-001273-plz1ja2e 115 52 ( ( -LRB- cord-001273-plz1ja2e 115 53 Trinchieri Trinchieri NNP cord-001273-plz1ja2e 115 54 , , , cord-001273-plz1ja2e 115 55 2010 2010 CD cord-001273-plz1ja2e 115 56 ) ) -RRB- cord-001273-plz1ja2e 115 57 . . . cord-001273-plz1ja2e 116 1 As as IN cord-001273-plz1ja2e 116 2 a a DT cord-001273-plz1ja2e 116 3 result result NN cord-001273-plz1ja2e 116 4 , , , cord-001273-plz1ja2e 116 5 type type NN cord-001273-plz1ja2e 116 6 I i NN cord-001273-plz1ja2e 116 7 - - HYPH cord-001273-plz1ja2e 116 8 IFNs IFNs NNP cord-001273-plz1ja2e 116 9 have have VBP cord-001273-plz1ja2e 116 10 a a DT cord-001273-plz1ja2e 116 11 therapeutic therapeutic JJ cord-001273-plz1ja2e 116 12 potential potential NN cord-001273-plz1ja2e 116 13 that that WDT cord-001273-plz1ja2e 116 14 can can MD cord-001273-plz1ja2e 116 15 be be VB cord-001273-plz1ja2e 116 16 used use VBN cord-001273-plz1ja2e 116 17 to to TO cord-001273-plz1ja2e 116 18 treat treat VB cord-001273-plz1ja2e 116 19 tumors tumor NNS cord-001273-plz1ja2e 116 20 and and CC cord-001273-plz1ja2e 116 21 viral viral JJ cord-001273-plz1ja2e 116 22 infections infection NNS cord-001273-plz1ja2e 116 23 ( ( -LRB- cord-001273-plz1ja2e 116 24 Pestka Pestka NNP cord-001273-plz1ja2e 116 25 , , , cord-001273-plz1ja2e 116 26 2007 2007 CD cord-001273-plz1ja2e 116 27 ; ; : cord-001273-plz1ja2e 116 28 Heim Heim NNP cord-001273-plz1ja2e 116 29 , , , cord-001273-plz1ja2e 116 30 2013 2013 CD cord-001273-plz1ja2e 116 31 ; ; : cord-001273-plz1ja2e 116 32 Wilson Wilson NNP cord-001273-plz1ja2e 116 33 and and CC cord-001273-plz1ja2e 116 34 Brooks Brooks NNP cord-001273-plz1ja2e 116 35 , , , cord-001273-plz1ja2e 116 36 2013 2013 CD cord-001273-plz1ja2e 116 37 ) ) -RRB- cord-001273-plz1ja2e 116 38 , , , cord-001273-plz1ja2e 116 39 while while IN cord-001273-plz1ja2e 116 40 being be VBG cord-001273-plz1ja2e 116 41 detrimental detrimental JJ cord-001273-plz1ja2e 116 42 for for IN cord-001273-plz1ja2e 116 43 the the DT cord-001273-plz1ja2e 116 44 host host NN cord-001273-plz1ja2e 116 45 in in IN cord-001273-plz1ja2e 116 46 response response NN cord-001273-plz1ja2e 116 47 to to IN cord-001273-plz1ja2e 116 48 a a DT cord-001273-plz1ja2e 116 49 subset subset NN cord-001273-plz1ja2e 116 50 of of IN cord-001273-plz1ja2e 116 51 pathogens pathogen NNS cord-001273-plz1ja2e 116 52 . . . cord-001273-plz1ja2e 117 1 Type Type NNP cord-001273-plz1ja2e 117 2 III III NNP cord-001273-plz1ja2e 117 3 - - HYPH cord-001273-plz1ja2e 117 4 IFNs ifns NN cord-001273-plz1ja2e 117 5 have have VBP cord-001273-plz1ja2e 117 6 been be VBN cord-001273-plz1ja2e 117 7 discovered discover VBN cord-001273-plz1ja2e 117 8 in in IN cord-001273-plz1ja2e 117 9 2003 2003 CD cord-001273-plz1ja2e 117 10 ( ( -LRB- cord-001273-plz1ja2e 117 11 Kotenko Kotenko NNP cord-001273-plz1ja2e 117 12 et et NNP cord-001273-plz1ja2e 117 13 al al NNP cord-001273-plz1ja2e 117 14 . . NNP cord-001273-plz1ja2e 117 15 , , , cord-001273-plz1ja2e 117 16 2003 2003 CD cord-001273-plz1ja2e 117 17 ; ; : cord-001273-plz1ja2e 117 18 Sheppard Sheppard NNP cord-001273-plz1ja2e 117 19 et et NNP cord-001273-plz1ja2e 117 20 al al NNP cord-001273-plz1ja2e 117 21 . . NNP cord-001273-plz1ja2e 117 22 , , , cord-001273-plz1ja2e 117 23 2003 2003 CD cord-001273-plz1ja2e 117 24 ) ) -RRB- cord-001273-plz1ja2e 117 25 and and CC cord-001273-plz1ja2e 117 26 their -PRON- PRP$ cord-001273-plz1ja2e 117 27 activities activity NNS cord-001273-plz1ja2e 117 28 have have VBP cord-001273-plz1ja2e 117 29 been be VBN cord-001273-plz1ja2e 117 30 less less RBR cord-001273-plz1ja2e 117 31 extensively extensively RB cord-001273-plz1ja2e 117 32 characterized characterize VBN cord-001273-plz1ja2e 117 33 than than IN cord-001273-plz1ja2e 117 34 those those DT cord-001273-plz1ja2e 117 35 of of IN cord-001273-plz1ja2e 117 36 type type NN cord-001273-plz1ja2e 117 37 I i NN cord-001273-plz1ja2e 117 38 - - HYPH cord-001273-plz1ja2e 117 39 and and CC cord-001273-plz1ja2e 117 40 type type NN cord-001273-plz1ja2e 117 41 II II NNP cord-001273-plz1ja2e 117 42 - - HYPH cord-001273-plz1ja2e 117 43 IFNs IFNs NNP cord-001273-plz1ja2e 117 44 . . . cord-001273-plz1ja2e 118 1 However however RB cord-001273-plz1ja2e 118 2 , , , cord-001273-plz1ja2e 118 3 several several JJ cord-001273-plz1ja2e 118 4 studies study NNS cord-001273-plz1ja2e 118 5 suggest suggest VBP cord-001273-plz1ja2e 118 6 that that DT cord-001273-plz1ja2e 118 7 type type NN cord-001273-plz1ja2e 118 8 I -PRON- PRP cord-001273-plz1ja2e 118 9 and and CC cord-001273-plz1ja2e 118 10 type type NN cord-001273-plz1ja2e 118 11 III iii CD cord-001273-plz1ja2e 118 12 - - HYPH cord-001273-plz1ja2e 118 13 IFNs ifns NN cord-001273-plz1ja2e 118 14 share share VBP cord-001273-plz1ja2e 118 15 common common JJ cord-001273-plz1ja2e 118 16 biological biological JJ cord-001273-plz1ja2e 118 17 activities activity NNS cord-001273-plz1ja2e 118 18 ( ( -LRB- cord-001273-plz1ja2e 118 19 Levy Levy NNP cord-001273-plz1ja2e 118 20 et et FW cord-001273-plz1ja2e 118 21 al al NNP cord-001273-plz1ja2e 118 22 . . NNP cord-001273-plz1ja2e 118 23 , , , cord-001273-plz1ja2e 118 24 2011 2011 CD cord-001273-plz1ja2e 118 25 ; ; : cord-001273-plz1ja2e 119 1 Zheng Zheng NNP cord-001273-plz1ja2e 119 2 et et NNP cord-001273-plz1ja2e 119 3 al al NNP cord-001273-plz1ja2e 119 4 . . NNP cord-001273-plz1ja2e 119 5 , , , cord-001273-plz1ja2e 119 6 2013 2013 CD cord-001273-plz1ja2e 119 7 ) ) -RRB- cord-001273-plz1ja2e 119 8 . . . cord-001273-plz1ja2e 120 1 Although although IN cord-001273-plz1ja2e 120 2 type type NN cord-001273-plz1ja2e 120 3 III III NNP cord-001273-plz1ja2e 120 4 - - HYPH cord-001273-plz1ja2e 120 5 IFNs ifns NN cord-001273-plz1ja2e 120 6 respond respond VBP cord-001273-plz1ja2e 120 7 to to IN cord-001273-plz1ja2e 120 8 different different JJ cord-001273-plz1ja2e 120 9 stimuli stimulus NNS cord-001273-plz1ja2e 120 10 , , , cord-001273-plz1ja2e 120 11 use use VBP cord-001273-plz1ja2e 120 12 different different JJ cord-001273-plz1ja2e 120 13 receptors receptor NNS cord-001273-plz1ja2e 120 14 and and CC cord-001273-plz1ja2e 120 15 are be VBP cord-001273-plz1ja2e 120 16 not not RB cord-001273-plz1ja2e 120 17 always always RB cord-001273-plz1ja2e 120 18 expressed express VBN cord-001273-plz1ja2e 120 19 by by IN cord-001273-plz1ja2e 120 20 the the DT cord-001273-plz1ja2e 120 21 same same JJ cord-001273-plz1ja2e 120 22 cells cell NNS cord-001273-plz1ja2e 120 23 as as IN cord-001273-plz1ja2e 120 24 type type NN cord-001273-plz1ja2e 120 25 I -PRON- PRP cord-001273-plz1ja2e 120 26 IFNs ifns VBP cord-001273-plz1ja2e 120 27 ( ( -LRB- cord-001273-plz1ja2e 120 28 see see VB cord-001273-plz1ja2e 120 29 below below RB cord-001273-plz1ja2e 120 30 ) ) -RRB- cord-001273-plz1ja2e 120 31 , , , cord-001273-plz1ja2e 120 32 engagement engagement NN cord-001273-plz1ja2e 120 33 of of IN cord-001273-plz1ja2e 120 34 type type NN cord-001273-plz1ja2e 120 35 I i NN cord-001273-plz1ja2e 120 36 - - HYPH cord-001273-plz1ja2e 120 37 and and CC cord-001273-plz1ja2e 120 38 type type NN cord-001273-plz1ja2e 120 39 III III NNP cord-001273-plz1ja2e 120 40 - - HYPH cord-001273-plz1ja2e 120 41 IFN IFN NNP cord-001273-plz1ja2e 120 42 receptors receptor NNS cord-001273-plz1ja2e 120 43 leads lead VBZ cord-001273-plz1ja2e 120 44 to to IN cord-001273-plz1ja2e 120 45 similar similar JJ cord-001273-plz1ja2e 120 46 transcriptional transcriptional JJ cord-001273-plz1ja2e 120 47 responses response NNS cord-001273-plz1ja2e 120 48 . . . cord-001273-plz1ja2e 121 1 Like like IN cord-001273-plz1ja2e 121 2 type type NN cord-001273-plz1ja2e 121 3 I i NN cord-001273-plz1ja2e 121 4 - - HYPH cord-001273-plz1ja2e 121 5 IFNs IFNs NNP cord-001273-plz1ja2e 121 6 , , , cord-001273-plz1ja2e 121 7 type type NN cord-001273-plz1ja2e 121 8 III III NNP cord-001273-plz1ja2e 121 9 - - HYPH cord-001273-plz1ja2e 121 10 IFNs IFNs NNP cord-001273-plz1ja2e 121 11 have have VBP cord-001273-plz1ja2e 121 12 been be VBN cord-001273-plz1ja2e 121 13 involved involve VBN cord-001273-plz1ja2e 121 14 in in IN cord-001273-plz1ja2e 121 15 antiproliferative antiproliferative JJ cord-001273-plz1ja2e 121 16 and and CC cord-001273-plz1ja2e 121 17 antiviral antiviral JJ cord-001273-plz1ja2e 121 18 responses response NNS cord-001273-plz1ja2e 121 19 ( ( -LRB- cord-001273-plz1ja2e 121 20 Iversen Iversen NNP cord-001273-plz1ja2e 121 21 and and CC cord-001273-plz1ja2e 121 22 Paludan Paludan NNP cord-001273-plz1ja2e 121 23 , , , cord-001273-plz1ja2e 121 24 2010 2010 CD cord-001273-plz1ja2e 121 25 ; ; : cord-001273-plz1ja2e 121 26 Mordstein Mordstein NNP cord-001273-plz1ja2e 121 27 et et NNP cord-001273-plz1ja2e 121 28 al al NNP cord-001273-plz1ja2e 121 29 . . NNP cord-001273-plz1ja2e 121 30 , , , cord-001273-plz1ja2e 121 31 2010 2010 CD cord-001273-plz1ja2e 121 32 ; ; : cord-001273-plz1ja2e 121 33 Durbin Durbin NNP cord-001273-plz1ja2e 121 34 et et NNP cord-001273-plz1ja2e 121 35 al al NNP cord-001273-plz1ja2e 121 36 . . NNP cord-001273-plz1ja2e 121 37 , , , cord-001273-plz1ja2e 121 38 2013 2013 CD cord-001273-plz1ja2e 121 39 ; ; : cord-001273-plz1ja2e 122 1 Hamming Hamming NNP cord-001273-plz1ja2e 122 2 et et FW cord-001273-plz1ja2e 122 3 al al NNP cord-001273-plz1ja2e 122 4 . . NNP cord-001273-plz1ja2e 122 5 , , , cord-001273-plz1ja2e 122 6 2013 2013 CD cord-001273-plz1ja2e 122 7 ) ) -RRB- cord-001273-plz1ja2e 122 8 . . . cord-001273-plz1ja2e 123 1 Recently recently RB cord-001273-plz1ja2e 123 2 , , , cord-001273-plz1ja2e 123 3 type type NN cord-001273-plz1ja2e 123 4 III III NNP cord-001273-plz1ja2e 123 5 - - HYPH cord-001273-plz1ja2e 123 6 IFNs IFNs NNP cord-001273-plz1ja2e 123 7 have have VBP cord-001273-plz1ja2e 123 8 been be VBN cord-001273-plz1ja2e 123 9 shown show VBN cord-001273-plz1ja2e 123 10 to to TO cord-001273-plz1ja2e 123 11 be be VB cord-001273-plz1ja2e 123 12 induced induce VBN cord-001273-plz1ja2e 123 13 in in IN cord-001273-plz1ja2e 123 14 response response NN cord-001273-plz1ja2e 123 15 to to IN cord-001273-plz1ja2e 123 16 bacterial bacterial JJ cord-001273-plz1ja2e 123 17 pathogens pathogen NNS cord-001273-plz1ja2e 123 18 , , , cord-001273-plz1ja2e 123 19 but but CC cord-001273-plz1ja2e 123 20 their -PRON- PRP$ cord-001273-plz1ja2e 123 21 downstream downstream JJ cord-001273-plz1ja2e 123 22 effects effect NNS cord-001273-plz1ja2e 123 23 are be VBP cord-001273-plz1ja2e 123 24 not not RB cord-001273-plz1ja2e 123 25 yet yet RB cord-001273-plz1ja2e 123 26 characterized characterize VBN cord-001273-plz1ja2e 123 27 ( ( -LRB- cord-001273-plz1ja2e 123 28 Pietilä Pietilä NNP cord-001273-plz1ja2e 123 29 et et FW cord-001273-plz1ja2e 123 30 al al NNP cord-001273-plz1ja2e 123 31 . . NNP cord-001273-plz1ja2e 123 32 , , , cord-001273-plz1ja2e 123 33 2010 2010 CD cord-001273-plz1ja2e 123 34 ; ; : cord-001273-plz1ja2e 123 35 Lebreton Lebreton NNP cord-001273-plz1ja2e 123 36 et et NNP cord-001273-plz1ja2e 123 37 al al NNP cord-001273-plz1ja2e 123 38 . . NNP cord-001273-plz1ja2e 123 39 , , , cord-001273-plz1ja2e 123 40 2011 2011 CD cord-001273-plz1ja2e 123 41 ; ; : cord-001273-plz1ja2e 124 1 Bierne Bierne NNP cord-001273-plz1ja2e 124 2 et et NNP cord-001273-plz1ja2e 124 3 al al NNP cord-001273-plz1ja2e 124 4 . . NNP cord-001273-plz1ja2e 124 5 , , , cord-001273-plz1ja2e 124 6 2012 2012 CD cord-001273-plz1ja2e 124 7 ) ) -RRB- cord-001273-plz1ja2e 124 8 . . . cord-001273-plz1ja2e 125 1 Transcription transcription NN cord-001273-plz1ja2e 125 2 of of IN cord-001273-plz1ja2e 125 3 IFN IFN NNP cord-001273-plz1ja2e 125 4 genes gene NNS cord-001273-plz1ja2e 125 5 is be VBZ cord-001273-plz1ja2e 125 6 induced induce VBN cord-001273-plz1ja2e 125 7 rapidly rapidly RB cord-001273-plz1ja2e 125 8 in in IN cord-001273-plz1ja2e 125 9 response response NN cord-001273-plz1ja2e 125 10 to to IN cord-001273-plz1ja2e 125 11 microbial microbial JJ cord-001273-plz1ja2e 125 12 infection infection NN cord-001273-plz1ja2e 125 13 . . . cord-001273-plz1ja2e 126 1 Type Type NNP cord-001273-plz1ja2e 126 2 I i NN cord-001273-plz1ja2e 126 3 - - HYPH cord-001273-plz1ja2e 126 4 IFNs IFNs NNP cord-001273-plz1ja2e 126 5 can can MD cord-001273-plz1ja2e 126 6 be be VB cord-001273-plz1ja2e 126 7 produced produce VBN cord-001273-plz1ja2e 126 8 by by IN cord-001273-plz1ja2e 126 9 all all DT cord-001273-plz1ja2e 126 10 cells cell NNS cord-001273-plz1ja2e 126 11 , , , cord-001273-plz1ja2e 126 12 while while IN cord-001273-plz1ja2e 126 13 type type NN cord-001273-plz1ja2e 126 14 III III NNP cord-001273-plz1ja2e 126 15 - - HYPH cord-001273-plz1ja2e 126 16 IFNs ifn NNS cord-001273-plz1ja2e 126 17 are be VBP cord-001273-plz1ja2e 126 18 secreted secrete VBN cord-001273-plz1ja2e 126 19 by by IN cord-001273-plz1ja2e 126 20 specific specific JJ cord-001273-plz1ja2e 126 21 cell cell NN cord-001273-plz1ja2e 126 22 types type NNS cord-001273-plz1ja2e 126 23 , , , cord-001273-plz1ja2e 126 24 including include VBG cord-001273-plz1ja2e 126 25 dendritic dendritic JJ cord-001273-plz1ja2e 126 26 and and CC cord-001273-plz1ja2e 126 27 epithelial epithelial JJ cord-001273-plz1ja2e 126 28 cells cell NNS cord-001273-plz1ja2e 126 29 . . . cord-001273-plz1ja2e 127 1 Type type NN cord-001273-plz1ja2e 127 2 I i NN cord-001273-plz1ja2e 127 3 - - HYPH cord-001273-plz1ja2e 127 4 and and CC cord-001273-plz1ja2e 127 5 type type NN cord-001273-plz1ja2e 127 6 III iii CD cord-001273-plz1ja2e 127 7 - - HYPH cord-001273-plz1ja2e 127 8 IFNs ifns NN cord-001273-plz1ja2e 127 9 activation activation NN cord-001273-plz1ja2e 127 10 is be VBZ cord-001273-plz1ja2e 127 11 initiated initiate VBN cord-001273-plz1ja2e 127 12 by by IN cord-001273-plz1ja2e 127 13 detection detection NN cord-001273-plz1ja2e 127 14 of of IN cord-001273-plz1ja2e 127 15 MAMPs mamp NNS cord-001273-plz1ja2e 127 16 by by IN cord-001273-plz1ja2e 127 17 PRRs prr NNS cord-001273-plz1ja2e 127 18 such such JJ cord-001273-plz1ja2e 127 19 as as IN cord-001273-plz1ja2e 127 20 endosomal endosomal NNP cord-001273-plz1ja2e 127 21 transmembrane transmembrane NNP cord-001273-plz1ja2e 127 22 Toll Toll NNP cord-001273-plz1ja2e 127 23 - - HYPH cord-001273-plz1ja2e 127 24 like like JJ cord-001273-plz1ja2e 127 25 receptors receptor NNS cord-001273-plz1ja2e 127 26 and and CC cord-001273-plz1ja2e 127 27 cytosolic cytosolic JJ cord-001273-plz1ja2e 127 28 receptors receptor NNS cord-001273-plz1ja2e 127 29 ( ( -LRB- cord-001273-plz1ja2e 127 30 Stetson Stetson NNP cord-001273-plz1ja2e 127 31 and and CC cord-001273-plz1ja2e 127 32 Medzhitov Medzhitov NNP cord-001273-plz1ja2e 127 33 , , , cord-001273-plz1ja2e 127 34 2006 2006 CD cord-001273-plz1ja2e 127 35 ; ; : cord-001273-plz1ja2e 127 36 Monroe Monroe NNP cord-001273-plz1ja2e 127 37 et et NNP cord-001273-plz1ja2e 127 38 al al NNP cord-001273-plz1ja2e 127 39 . . NNP cord-001273-plz1ja2e 127 40 , , , cord-001273-plz1ja2e 127 41 2010 2010 CD cord-001273-plz1ja2e 127 42 ) ) -RRB- cord-001273-plz1ja2e 127 43 . . . cord-001273-plz1ja2e 128 1 Upon upon IN cord-001273-plz1ja2e 128 2 recognition recognition NN cord-001273-plz1ja2e 128 3 of of IN cord-001273-plz1ja2e 128 4 MAMPs mamp NNS cord-001273-plz1ja2e 128 5 , , , cord-001273-plz1ja2e 128 6 PRRs PRRs NNP cord-001273-plz1ja2e 128 7 trigger trigger NN cord-001273-plz1ja2e 128 8 diverse diverse JJ cord-001273-plz1ja2e 128 9 signaling signal VBG cord-001273-plz1ja2e 128 10 pathways pathway NNS cord-001273-plz1ja2e 128 11 that that WDT cord-001273-plz1ja2e 128 12 involve involve VBP cord-001273-plz1ja2e 128 13 adaptor adaptor NN cord-001273-plz1ja2e 128 14 proteins protein NNS cord-001273-plz1ja2e 128 15 and and CC cord-001273-plz1ja2e 128 16 cytosolic cytosolic JJ cord-001273-plz1ja2e 128 17 or or CC cord-001273-plz1ja2e 128 18 organelle organelle NN cord-001273-plz1ja2e 128 19 - - HYPH cord-001273-plz1ja2e 128 20 bound bind VBN cord-001273-plz1ja2e 128 21 protein protein NN cord-001273-plz1ja2e 128 22 scaffolds scaffold NNS cord-001273-plz1ja2e 128 23 activating activate VBG cord-001273-plz1ja2e 128 24 kinases kinase NNS cord-001273-plz1ja2e 128 25 converging converge VBG cord-001273-plz1ja2e 128 26 to to IN cord-001273-plz1ja2e 128 27 phosphorylation phosphorylation NN cord-001273-plz1ja2e 128 28 of of IN cord-001273-plz1ja2e 128 29 transcription transcription NN cord-001273-plz1ja2e 128 30 factors factor NNS cord-001273-plz1ja2e 128 31 and and CC cord-001273-plz1ja2e 128 32 their -PRON- PRP$ cord-001273-plz1ja2e 128 33 subsequent subsequent JJ cord-001273-plz1ja2e 128 34 translocation translocation NN cord-001273-plz1ja2e 128 35 into into IN cord-001273-plz1ja2e 128 36 the the DT cord-001273-plz1ja2e 128 37 nucleus nucleus NN cord-001273-plz1ja2e 128 38 ( ( -LRB- cord-001273-plz1ja2e 128 39 Figure figure NN cord-001273-plz1ja2e 128 40 1 1 CD cord-001273-plz1ja2e 128 41 ) ) -RRB- cord-001273-plz1ja2e 128 42 . . . cord-001273-plz1ja2e 129 1 IRF1 IRF1 NNP cord-001273-plz1ja2e 129 2 , , , cord-001273-plz1ja2e 129 3 IRF3 IRF3 NNP cord-001273-plz1ja2e 129 4 , , , cord-001273-plz1ja2e 129 5 IRF4 IRF4 NNP cord-001273-plz1ja2e 129 6 , , , cord-001273-plz1ja2e 129 7 IRF5 IRF5 NNP cord-001273-plz1ja2e 129 8 , , , cord-001273-plz1ja2e 129 9 IRF7 IRF7 NNP cord-001273-plz1ja2e 129 10 , , , cord-001273-plz1ja2e 129 11 and and CC cord-001273-plz1ja2e 129 12 IRF8 IRF8 NNP cord-001273-plz1ja2e 129 13 are be VBP cord-001273-plz1ja2e 129 14 important important JJ cord-001273-plz1ja2e 129 15 for for IN cord-001273-plz1ja2e 129 16 transcription transcription NN cord-001273-plz1ja2e 129 17 of of IN cord-001273-plz1ja2e 129 18 the the DT cord-001273-plz1ja2e 129 19 IFN IFN NNP cord-001273-plz1ja2e 129 20 - - HYPH cord-001273-plz1ja2e 129 21 α α NNP cord-001273-plz1ja2e 129 22 genes gene NNS cord-001273-plz1ja2e 129 23 , , , cord-001273-plz1ja2e 129 24 with with IN cord-001273-plz1ja2e 129 25 IRF7 IRF7 NNP cord-001273-plz1ja2e 129 26 considered consider VBN cord-001273-plz1ja2e 129 27 as as IN cord-001273-plz1ja2e 129 28 the the DT cord-001273-plz1ja2e 129 29 master master NN cord-001273-plz1ja2e 129 30 regulator regulator NN cord-001273-plz1ja2e 129 31 of of IN cord-001273-plz1ja2e 129 32 IFN IFN NNP cord-001273-plz1ja2e 129 33 - - HYPH cord-001273-plz1ja2e 129 34 α α NNP cord-001273-plz1ja2e 129 35 response response NN cord-001273-plz1ja2e 130 1 ( ( -LRB- cord-001273-plz1ja2e 130 2 Honda Honda NNP cord-001273-plz1ja2e 130 3 et et NNP cord-001273-plz1ja2e 130 4 al al NNP cord-001273-plz1ja2e 130 5 . . . cord-001273-plz1ja2e 131 1 , , , cord-001273-plz1ja2e 131 2 2005 2005 CD cord-001273-plz1ja2e 131 3 ; ; : cord-001273-plz1ja2e 131 4 Tailor Tailor NNP cord-001273-plz1ja2e 131 5 et et NNP cord-001273-plz1ja2e 131 6 al al NNP cord-001273-plz1ja2e 131 7 . . NNP cord-001273-plz1ja2e 131 8 , , , cord-001273-plz1ja2e 131 9 2007 2007 CD cord-001273-plz1ja2e 131 10 ; ; : cord-001273-plz1ja2e 131 11 Levy Levy NNP cord-001273-plz1ja2e 131 12 et et NNP cord-001273-plz1ja2e 131 13 al al NNP cord-001273-plz1ja2e 131 14 . . NNP cord-001273-plz1ja2e 131 15 , , , cord-001273-plz1ja2e 131 16 2011 2011 CD cord-001273-plz1ja2e 131 17 ) ) -RRB- cord-001273-plz1ja2e 131 18 . . . cord-001273-plz1ja2e 132 1 Regulation regulation NN cord-001273-plz1ja2e 132 2 of of IN cord-001273-plz1ja2e 132 3 the the DT cord-001273-plz1ja2e 132 4 IFNβ IFNβ NNS cord-001273-plz1ja2e 132 5 gene gene NN cord-001273-plz1ja2e 132 6 is be VBZ cord-001273-plz1ja2e 132 7 more more RBR cord-001273-plz1ja2e 132 8 complex complex JJ cord-001273-plz1ja2e 132 9 . . . cord-001273-plz1ja2e 133 1 Activated Activated NNP cord-001273-plz1ja2e 133 2 IRF3 IRF3 NNP cord-001273-plz1ja2e 133 3 , , , cord-001273-plz1ja2e 133 4 IRF7 IRF7 NNP cord-001273-plz1ja2e 133 5 , , , cord-001273-plz1ja2e 133 6 AP-1 AP-1 NNP cord-001273-plz1ja2e 133 7 , , , cord-001273-plz1ja2e 133 8 and and CC cord-001273-plz1ja2e 133 9 NF nf NN cord-001273-plz1ja2e 133 10 - - HYPH cord-001273-plz1ja2e 133 11 κB κb CD cord-001273-plz1ja2e 133 12 bind bind NN cord-001273-plz1ja2e 133 13 to to IN cord-001273-plz1ja2e 133 14 the the DT cord-001273-plz1ja2e 133 15 enhancer enhancer NN cord-001273-plz1ja2e 133 16 / / SYM cord-001273-plz1ja2e 133 17 promoter promoter NN cord-001273-plz1ja2e 133 18 regions region NNS cord-001273-plz1ja2e 133 19 of of IN cord-001273-plz1ja2e 133 20 the the DT cord-001273-plz1ja2e 133 21 IFN IFN NNP cord-001273-plz1ja2e 133 22 - - HYPH cord-001273-plz1ja2e 133 23 β β NNP cord-001273-plz1ja2e 133 24 gene gene NN cord-001273-plz1ja2e 133 25 and and CC cord-001273-plz1ja2e 133 26 participate participate VB cord-001273-plz1ja2e 133 27 to to IN cord-001273-plz1ja2e 133 28 the the DT cord-001273-plz1ja2e 133 29 formation formation NN cord-001273-plz1ja2e 133 30 of of IN cord-001273-plz1ja2e 133 31 the the DT cord-001273-plz1ja2e 133 32 enhanceosome enhanceosome NN cord-001273-plz1ja2e 133 33 , , , cord-001273-plz1ja2e 133 34 which which WDT cord-001273-plz1ja2e 133 35 alters alter VBZ cord-001273-plz1ja2e 133 36 chromatin chromatin NN cord-001273-plz1ja2e 133 37 structure structure NN cord-001273-plz1ja2e 133 38 and and CC cord-001273-plz1ja2e 133 39 allows allow VBZ cord-001273-plz1ja2e 133 40 transcription transcription NN cord-001273-plz1ja2e 133 41 ( ( -LRB- cord-001273-plz1ja2e 133 42 Panne Panne NNP cord-001273-plz1ja2e 133 43 et et FW cord-001273-plz1ja2e 133 44 al al NNP cord-001273-plz1ja2e 133 45 . . NNP cord-001273-plz1ja2e 133 46 , , , cord-001273-plz1ja2e 133 47 2007 2007 CD cord-001273-plz1ja2e 133 48 ; ; : cord-001273-plz1ja2e 133 49 Panne Panne NNP cord-001273-plz1ja2e 133 50 , , , cord-001273-plz1ja2e 133 51 2008 2008 CD cord-001273-plz1ja2e 133 52 ) ) -RRB- cord-001273-plz1ja2e 133 53 . . . cord-001273-plz1ja2e 134 1 In in IN cord-001273-plz1ja2e 134 2 contrast contrast NN cord-001273-plz1ja2e 134 3 , , , cord-001273-plz1ja2e 134 4 IRFs irfs NN cord-001273-plz1ja2e 134 5 and and CC cord-001273-plz1ja2e 134 6 NF nf NN cord-001273-plz1ja2e 134 7 - - HYPH cord-001273-plz1ja2e 134 8 κB κB NNP cord-001273-plz1ja2e 134 9 independently independently RB cord-001273-plz1ja2e 134 10 activate activate VBP cord-001273-plz1ja2e 134 11 transcription transcription NN cord-001273-plz1ja2e 134 12 of of IN cord-001273-plz1ja2e 134 13 type type NN cord-001273-plz1ja2e 134 14 III III NNP cord-001273-plz1ja2e 134 15 - - HYPH cord-001273-plz1ja2e 134 16 IFN IFN NNP cord-001273-plz1ja2e 134 17 genes gene NNS cord-001273-plz1ja2e 134 18 ( ( -LRB- cord-001273-plz1ja2e 134 19 Iversen Iversen NNP cord-001273-plz1ja2e 134 20 and and CC cord-001273-plz1ja2e 134 21 Paludan Paludan NNP cord-001273-plz1ja2e 134 22 , , , cord-001273-plz1ja2e 134 23 2010 2010 CD cord-001273-plz1ja2e 134 24 ) ) -RRB- cord-001273-plz1ja2e 134 25 . . . cord-001273-plz1ja2e 135 1 Regulation regulation NN cord-001273-plz1ja2e 135 2 of of IN cord-001273-plz1ja2e 135 3 the the DT cord-001273-plz1ja2e 135 4 IFN IFN NNP cord-001273-plz1ja2e 135 5 - - HYPH cord-001273-plz1ja2e 135 6 γ γ NN cord-001273-plz1ja2e 135 7 gene gene NN cord-001273-plz1ja2e 135 8 expression expression NN cord-001273-plz1ja2e 135 9 is be VBZ cord-001273-plz1ja2e 135 10 different different JJ cord-001273-plz1ja2e 135 11 from from IN cord-001273-plz1ja2e 135 12 that that DT cord-001273-plz1ja2e 135 13 of of IN cord-001273-plz1ja2e 135 14 type type NN cord-001273-plz1ja2e 135 15 I -PRON- PRP cord-001273-plz1ja2e 135 16 and and CC cord-001273-plz1ja2e 135 17 type type NN cord-001273-plz1ja2e 135 18 III III NNP cord-001273-plz1ja2e 135 19 - - HYPH cord-001273-plz1ja2e 135 20 IFN IFN NNP cord-001273-plz1ja2e 135 21 genes gene NNS cord-001273-plz1ja2e 135 22 . . . cord-001273-plz1ja2e 136 1 NK NK NNP cord-001273-plz1ja2e 136 2 cells cell NNS cord-001273-plz1ja2e 136 3 and and CC cord-001273-plz1ja2e 136 4 NKT NKT NNP cord-001273-plz1ja2e 136 5 cells cell NNS cord-001273-plz1ja2e 136 6 are be VBP cord-001273-plz1ja2e 136 7 effectors effector NNS cord-001273-plz1ja2e 136 8 of of IN cord-001273-plz1ja2e 136 9 the the DT cord-001273-plz1ja2e 136 10 innate innate JJ cord-001273-plz1ja2e 136 11 immune immune JJ cord-001273-plz1ja2e 136 12 response response NN cord-001273-plz1ja2e 136 13 and and CC cord-001273-plz1ja2e 136 14 primary primary JJ cord-001273-plz1ja2e 136 15 sources source NNS cord-001273-plz1ja2e 136 16 of of IN cord-001273-plz1ja2e 136 17 IFN IFN NNP cord-001273-plz1ja2e 136 18 - - HYPH cord-001273-plz1ja2e 136 19 γ γ NNP cord-001273-plz1ja2e 136 20 . . . cord-001273-plz1ja2e 137 1 Mature mature JJ cord-001273-plz1ja2e 137 2 NK NK NNP cord-001273-plz1ja2e 137 3 and and CC cord-001273-plz1ja2e 137 4 NKT NKT NNP cord-001273-plz1ja2e 137 5 cells cell NNS cord-001273-plz1ja2e 137 6 quickly quickly RB cord-001273-plz1ja2e 137 7 react react VBP cord-001273-plz1ja2e 137 8 to to IN cord-001273-plz1ja2e 137 9 infection infection NN cord-001273-plz1ja2e 137 10 by by IN cord-001273-plz1ja2e 137 11 inducing induce VBG cord-001273-plz1ja2e 137 12 IFN IFN NNP cord-001273-plz1ja2e 137 13 - - HYPH cord-001273-plz1ja2e 137 14 γ γ NN cord-001273-plz1ja2e 137 15 secretion secretion NN cord-001273-plz1ja2e 137 16 . . . cord-001273-plz1ja2e 138 1 Upon upon IN cord-001273-plz1ja2e 138 2 recognition recognition NN cord-001273-plz1ja2e 138 3 of of IN cord-001273-plz1ja2e 138 4 ligands ligand NNS cord-001273-plz1ja2e 138 5 expressed express VBN cord-001273-plz1ja2e 138 6 on on IN cord-001273-plz1ja2e 138 7 infected infected JJ cord-001273-plz1ja2e 138 8 cells cell NNS cord-001273-plz1ja2e 138 9 , , , cord-001273-plz1ja2e 138 10 NK NK NNP cord-001273-plz1ja2e 138 11 cell cell NN cord-001273-plz1ja2e 138 12 activating activate VBG cord-001273-plz1ja2e 138 13 - - HYPH cord-001273-plz1ja2e 138 14 receptors receptor NNS cord-001273-plz1ja2e 138 15 trigger trigger NN cord-001273-plz1ja2e 138 16 signaling signal VBG cord-001273-plz1ja2e 138 17 cascades cascade NNS cord-001273-plz1ja2e 138 18 involving involve VBG cord-001273-plz1ja2e 138 19 adaptor adaptor NN cord-001273-plz1ja2e 138 20 proteins protein NNS cord-001273-plz1ja2e 138 21 and and CC cord-001273-plz1ja2e 138 22 protein protein NN cord-001273-plz1ja2e 138 23 tyrosine tyrosine NN cord-001273-plz1ja2e 138 24 kinases kinase NNS cord-001273-plz1ja2e 138 25 leading lead VBG cord-001273-plz1ja2e 138 26 to to IN cord-001273-plz1ja2e 138 27 activation activation NN cord-001273-plz1ja2e 138 28 of of IN cord-001273-plz1ja2e 138 29 Ras Ras NNP cord-001273-plz1ja2e 138 30 / / SYM cord-001273-plz1ja2e 138 31 Sos Sos NNP cord-001273-plz1ja2e 138 32 , , , cord-001273-plz1ja2e 138 33 PLC PLC NNP cord-001273-plz1ja2e 138 34 - - HYPH cord-001273-plz1ja2e 138 35 γ γ NNP cord-001273-plz1ja2e 138 36 and and CC cord-001273-plz1ja2e 138 37 MAPK MAPK NNP cord-001273-plz1ja2e 138 38 pathways pathway NNS cord-001273-plz1ja2e 138 39 and and CC cord-001273-plz1ja2e 138 40 induction induction NN cord-001273-plz1ja2e 138 41 of of IN cord-001273-plz1ja2e 138 42 IFN IFN NNP cord-001273-plz1ja2e 138 43 - - HYPH cord-001273-plz1ja2e 138 44 γ γ NN cord-001273-plz1ja2e 138 45 production production NN cord-001273-plz1ja2e 138 46 ( ( -LRB- cord-001273-plz1ja2e 138 47 Schoenborn Schoenborn NNP cord-001273-plz1ja2e 138 48 and and CC cord-001273-plz1ja2e 138 49 Wilson Wilson NNP cord-001273-plz1ja2e 138 50 , , , cord-001273-plz1ja2e 138 51 2007 2007 CD cord-001273-plz1ja2e 138 52 ) ) -RRB- cord-001273-plz1ja2e 138 53 . . . cord-001273-plz1ja2e 139 1 In in IN cord-001273-plz1ja2e 139 2 addition addition NN cord-001273-plz1ja2e 139 3 to to IN cord-001273-plz1ja2e 139 4 receptors receptor NNS cord-001273-plz1ja2e 139 5 , , , cord-001273-plz1ja2e 139 6 IL-2 IL-2 NNP cord-001273-plz1ja2e 139 7 , , , cord-001273-plz1ja2e 139 8 IL-15 IL-15 NNP cord-001273-plz1ja2e 139 9 , , , cord-001273-plz1ja2e 139 10 IL-12 IL-12 NNP cord-001273-plz1ja2e 139 11 , , , cord-001273-plz1ja2e 139 12 IL-18 IL-18 NNP cord-001273-plz1ja2e 139 13 , , , cord-001273-plz1ja2e 139 14 and and CC cord-001273-plz1ja2e 139 15 type type NN cord-001273-plz1ja2e 139 16 I i NN cord-001273-plz1ja2e 139 17 - - HYPH cord-001273-plz1ja2e 139 18 IFNs IFNs NNP cord-001273-plz1ja2e 139 19 also also RB cord-001273-plz1ja2e 139 20 contribute contribute VBP cord-001273-plz1ja2e 139 21 to to IN cord-001273-plz1ja2e 139 22 induction induction NN cord-001273-plz1ja2e 139 23 of of IN cord-001273-plz1ja2e 139 24 IFN IFN NNP cord-001273-plz1ja2e 139 25 - - HYPH cord-001273-plz1ja2e 139 26 γ γ NN cord-001273-plz1ja2e 139 27 production production NN cord-001273-plz1ja2e 139 28 by by IN cord-001273-plz1ja2e 139 29 NK NK NNP cord-001273-plz1ja2e 139 30 cells cell NNS cord-001273-plz1ja2e 139 31 ( ( -LRB- cord-001273-plz1ja2e 139 32 Newman Newman NNP cord-001273-plz1ja2e 139 33 and and CC cord-001273-plz1ja2e 139 34 Riley Riley NNP cord-001273-plz1ja2e 139 35 , , , cord-001273-plz1ja2e 139 36 2007 2007 CD cord-001273-plz1ja2e 139 37 ; ; : cord-001273-plz1ja2e 139 38 Schoenborn Schoenborn NNP cord-001273-plz1ja2e 139 39 and and CC cord-001273-plz1ja2e 139 40 Wilson Wilson NNP cord-001273-plz1ja2e 139 41 , , , cord-001273-plz1ja2e 139 42 2007 2007 CD cord-001273-plz1ja2e 139 43 ; ; : cord-001273-plz1ja2e 139 44 Marçais Marçais NNP cord-001273-plz1ja2e 139 45 et et NNP cord-001273-plz1ja2e 139 46 al al NNP cord-001273-plz1ja2e 139 47 . . NNP cord-001273-plz1ja2e 139 48 , , , cord-001273-plz1ja2e 139 49 2013 2013 CD cord-001273-plz1ja2e 139 50 ) ) -RRB- cord-001273-plz1ja2e 139 51 . . . cord-001273-plz1ja2e 140 1 Similarly similarly RB cord-001273-plz1ja2e 140 2 , , , cord-001273-plz1ja2e 140 3 IL-12 IL-12 NNP cord-001273-plz1ja2e 140 4 and and CC cord-001273-plz1ja2e 140 5 IL-18 IL-18 NNP cord-001273-plz1ja2e 140 6 induce induce VB cord-001273-plz1ja2e 140 7 IFN IFN NNP cord-001273-plz1ja2e 140 8 - - HYPH cord-001273-plz1ja2e 140 9 γ γ NN cord-001273-plz1ja2e 140 10 production production NN cord-001273-plz1ja2e 140 11 by by IN cord-001273-plz1ja2e 140 12 NKT NKT NNP cord-001273-plz1ja2e 140 13 cells cell NNS cord-001273-plz1ja2e 140 14 ( ( -LRB- cord-001273-plz1ja2e 140 15 Godfrey Godfrey NNP cord-001273-plz1ja2e 140 16 and and CC cord-001273-plz1ja2e 140 17 Berzins Berzins NNP cord-001273-plz1ja2e 140 18 , , , cord-001273-plz1ja2e 140 19 2007 2007 CD cord-001273-plz1ja2e 140 20 ) ) -RRB- cord-001273-plz1ja2e 140 21 . . . cord-001273-plz1ja2e 141 1 In in IN cord-001273-plz1ja2e 141 2 NK NK NNP cord-001273-plz1ja2e 141 3 and and CC cord-001273-plz1ja2e 141 4 NKT NKT NNP cord-001273-plz1ja2e 141 5 cells cell NNS cord-001273-plz1ja2e 141 6 , , , cord-001273-plz1ja2e 141 7 the the DT cord-001273-plz1ja2e 141 8 IFN IFN NNP cord-001273-plz1ja2e 141 9 - - HYPH cord-001273-plz1ja2e 141 10 γ γ NNP cord-001273-plz1ja2e 141 11 gene gene NN cord-001273-plz1ja2e 141 12 locus locus NN cord-001273-plz1ja2e 141 13 is be VBZ cord-001273-plz1ja2e 141 14 transcriptionally transcriptionally RB cord-001273-plz1ja2e 141 15 permissive permissive JJ cord-001273-plz1ja2e 141 16 within within IN cord-001273-plz1ja2e 141 17 accessible accessible JJ cord-001273-plz1ja2e 141 18 chromatin chromatin NN cord-001273-plz1ja2e 141 19 and and CC cord-001273-plz1ja2e 141 20 allows allow VBZ cord-001273-plz1ja2e 141 21 rapid rapid JJ cord-001273-plz1ja2e 141 22 IFN IFN NNP cord-001273-plz1ja2e 141 23 - - HYPH cord-001273-plz1ja2e 141 24 γ γ NN cord-001273-plz1ja2e 141 25 expression expression NN cord-001273-plz1ja2e 141 26 upon upon IN cord-001273-plz1ja2e 141 27 activation activation NN cord-001273-plz1ja2e 141 28 of of IN cord-001273-plz1ja2e 141 29 transcription transcription NN cord-001273-plz1ja2e 141 30 factors factor NNS cord-001273-plz1ja2e 141 31 , , , cord-001273-plz1ja2e 141 32 such such JJ cord-001273-plz1ja2e 141 33 as as IN cord-001273-plz1ja2e 141 34 AP-1 AP-1 NNP cord-001273-plz1ja2e 141 35 , , , cord-001273-plz1ja2e 141 36 NF NF NNP cord-001273-plz1ja2e 141 37 - - HYPH cord-001273-plz1ja2e 141 38 κB κB NNP cord-001273-plz1ja2e 141 39 , , , cord-001273-plz1ja2e 141 40 STAT4 stat4 NN cord-001273-plz1ja2e 141 41 , , , cord-001273-plz1ja2e 141 42 and and CC cord-001273-plz1ja2e 141 43 T t NN cord-001273-plz1ja2e 141 44 - - HYPH cord-001273-plz1ja2e 141 45 bet bet NN cord-001273-plz1ja2e 142 1 ( ( -LRB- cord-001273-plz1ja2e 142 2 Glimcher Glimcher NNP cord-001273-plz1ja2e 142 3 et et NNP cord-001273-plz1ja2e 142 4 al al NNP cord-001273-plz1ja2e 142 5 . . NNP cord-001273-plz1ja2e 142 6 , , , cord-001273-plz1ja2e 142 7 2004 2004 CD cord-001273-plz1ja2e 142 8 ; ; : cord-001273-plz1ja2e 142 9 Schoenborn Schoenborn NNP cord-001273-plz1ja2e 142 10 and and CC cord-001273-plz1ja2e 142 11 Wilson Wilson NNP cord-001273-plz1ja2e 142 12 , , , cord-001273-plz1ja2e 142 13 2007 2007 CD cord-001273-plz1ja2e 142 14 ; ; : cord-001273-plz1ja2e 142 15 Lazarevic Lazarevic NNP cord-001273-plz1ja2e 142 16 et et FW cord-001273-plz1ja2e 142 17 al al NNP cord-001273-plz1ja2e 142 18 . . NNP cord-001273-plz1ja2e 142 19 , , , cord-001273-plz1ja2e 142 20 2013 2013 CD cord-001273-plz1ja2e 142 21 ) ) -RRB- cord-001273-plz1ja2e 142 22 . . . cord-001273-plz1ja2e 143 1 In in IN cord-001273-plz1ja2e 143 2 addition addition NN cord-001273-plz1ja2e 143 3 , , , cord-001273-plz1ja2e 143 4 naive naive JJ cord-001273-plz1ja2e 143 5 CD4 CD4 NNP cord-001273-plz1ja2e 143 6 and and CC cord-001273-plz1ja2e 143 7 CD8 CD8 NNP cord-001273-plz1ja2e 143 8 T T NNP cord-001273-plz1ja2e 143 9 cells cell NNS cord-001273-plz1ja2e 143 10 can can MD cord-001273-plz1ja2e 143 11 differentiate differentiate VB cord-001273-plz1ja2e 143 12 into into IN cord-001273-plz1ja2e 143 13 Th1 Th1 NNP cord-001273-plz1ja2e 143 14 CD4 CD4 NNP cord-001273-plz1ja2e 143 15 effector effector VBP cord-001273-plz1ja2e 143 16 T T NNP cord-001273-plz1ja2e 143 17 cells cell NNS cord-001273-plz1ja2e 143 18 and and CC cord-001273-plz1ja2e 143 19 CD8 CD8 NNP cord-001273-plz1ja2e 143 20 cytotoxic cytotoxic JJ cord-001273-plz1ja2e 143 21 T T NNP cord-001273-plz1ja2e 143 22 lymphocytes lymphocyte NNS cord-001273-plz1ja2e 143 23 capable capable JJ cord-001273-plz1ja2e 143 24 of of IN cord-001273-plz1ja2e 143 25 IFN IFN NNP cord-001273-plz1ja2e 143 26 - - HYPH cord-001273-plz1ja2e 143 27 γ γ NN cord-001273-plz1ja2e 143 28 secretion secretion NN cord-001273-plz1ja2e 144 1 ( ( -LRB- cord-001273-plz1ja2e 144 2 Wilson Wilson NNP cord-001273-plz1ja2e 144 3 et et NNP cord-001273-plz1ja2e 144 4 al al NNP cord-001273-plz1ja2e 144 5 . . NNP cord-001273-plz1ja2e 144 6 , , , cord-001273-plz1ja2e 144 7 2009 2009 CD cord-001273-plz1ja2e 144 8 ) ) -RRB- cord-001273-plz1ja2e 144 9 . . . cord-001273-plz1ja2e 145 1 IFN IFN NNP cord-001273-plz1ja2e 145 2 - - HYPH cord-001273-plz1ja2e 145 3 γ γ NN cord-001273-plz1ja2e 145 4 production production NN cord-001273-plz1ja2e 145 5 by by IN cord-001273-plz1ja2e 145 6 CD4 CD4 NNP cord-001273-plz1ja2e 145 7 and and CC cord-001273-plz1ja2e 145 8 CD8 CD8 NNP cord-001273-plz1ja2e 145 9 T T NNP cord-001273-plz1ja2e 145 10 cells cell NNS cord-001273-plz1ja2e 145 11 depends depend VBZ cord-001273-plz1ja2e 145 12 on on IN cord-001273-plz1ja2e 145 13 IL-12 IL-12 NNP cord-001273-plz1ja2e 145 14 , , , cord-001273-plz1ja2e 145 15 IL-18 IL-18 NNP cord-001273-plz1ja2e 145 16 and and CC cord-001273-plz1ja2e 145 17 IFN IFN NNP cord-001273-plz1ja2e 145 18 - - HYPH cord-001273-plz1ja2e 145 19 γ γ NNP cord-001273-plz1ja2e 145 20 itself -PRON- PRP cord-001273-plz1ja2e 145 21 and and CC cord-001273-plz1ja2e 145 22 share share VB cord-001273-plz1ja2e 145 23 many many JJ cord-001273-plz1ja2e 145 24 signaling signal VBG cord-001273-plz1ja2e 145 25 pathways pathway NNS cord-001273-plz1ja2e 145 26 with with IN cord-001273-plz1ja2e 145 27 NK NK NNP cord-001273-plz1ja2e 145 28 cells cell NNS cord-001273-plz1ja2e 145 29 . . . cord-001273-plz1ja2e 146 1 Multiple multiple JJ cord-001273-plz1ja2e 146 2 transcription transcription NN cord-001273-plz1ja2e 146 3 factors factor NNS cord-001273-plz1ja2e 146 4 act act VBP cord-001273-plz1ja2e 146 5 at at IN cord-001273-plz1ja2e 146 6 the the DT cord-001273-plz1ja2e 146 7 IFN IFN NNP cord-001273-plz1ja2e 146 8 - - HYPH cord-001273-plz1ja2e 146 9 γ γ NN cord-001273-plz1ja2e 146 10 promoter promoter NN cord-001273-plz1ja2e 146 11 , , , cord-001273-plz1ja2e 146 12 e.g. e.g. RB cord-001273-plz1ja2e 146 13 , , , cord-001273-plz1ja2e 146 14 AP-1 AP-1 NNP cord-001273-plz1ja2e 146 15 , , , cord-001273-plz1ja2e 146 16 ATF-2 ATF-2 NNP cord-001273-plz1ja2e 146 17 / / SYM cord-001273-plz1ja2e 146 18 c c NNP cord-001273-plz1ja2e 146 19 - - : cord-001273-plz1ja2e 146 20 Jun Jun NNP cord-001273-plz1ja2e 146 21 , , , cord-001273-plz1ja2e 146 22 C C NNP cord-001273-plz1ja2e 146 23 / / SYM cord-001273-plz1ja2e 146 24 EBP ebp NN cord-001273-plz1ja2e 146 25 , , , cord-001273-plz1ja2e 146 26 Eomes Eomes NNP cord-001273-plz1ja2e 146 27 , , , cord-001273-plz1ja2e 146 28 Ets-1 Ets-1 NNP cord-001273-plz1ja2e 146 29 , , , cord-001273-plz1ja2e 146 30 NFAT NFAT NNP cord-001273-plz1ja2e 146 31 , , , cord-001273-plz1ja2e 146 32 NF NF NNP cord-001273-plz1ja2e 146 33 - - HYPH cord-001273-plz1ja2e 146 34 κB κB NNP cord-001273-plz1ja2e 146 35 , , , cord-001273-plz1ja2e 147 1 Runx3 Runx3 NNP cord-001273-plz1ja2e 147 2 , , , cord-001273-plz1ja2e 147 3 STATs STATs NNP cord-001273-plz1ja2e 147 4 and and CC cord-001273-plz1ja2e 147 5 T t NN cord-001273-plz1ja2e 147 6 - - HYPH cord-001273-plz1ja2e 147 7 bet bet NN cord-001273-plz1ja2e 147 8 ( ( -LRB- cord-001273-plz1ja2e 147 9 Schoenborn Schoenborn NNP cord-001273-plz1ja2e 147 10 and and CC cord-001273-plz1ja2e 147 11 Wilson Wilson NNP cord-001273-plz1ja2e 147 12 , , , cord-001273-plz1ja2e 147 13 2007 2007 CD cord-001273-plz1ja2e 147 14 ; ; . cord-001273-plz1ja2e 148 1 Samten Samten NNP cord-001273-plz1ja2e 148 2 et et NNP cord-001273-plz1ja2e 148 3 al al NNP cord-001273-plz1ja2e 148 4 . . NNP cord-001273-plz1ja2e 148 5 , , , cord-001273-plz1ja2e 148 6 2008 2008 CD cord-001273-plz1ja2e 148 7 ; ; : cord-001273-plz1ja2e 148 8 Wilson Wilson NNP cord-001273-plz1ja2e 148 9 et et NNP cord-001273-plz1ja2e 148 10 al al NNP cord-001273-plz1ja2e 148 11 . . NNP cord-001273-plz1ja2e 148 12 , , , cord-001273-plz1ja2e 148 13 2009 2009 CD cord-001273-plz1ja2e 149 1 ; ; : cord-001273-plz1ja2e 149 2 Lazarevic Lazarevic NNP cord-001273-plz1ja2e 149 3 et et FW cord-001273-plz1ja2e 149 4 al al NNP cord-001273-plz1ja2e 149 5 . . NNP cord-001273-plz1ja2e 149 6 , , , cord-001273-plz1ja2e 149 7 2013 2013 CD cord-001273-plz1ja2e 149 8 ) ) -RRB- cord-001273-plz1ja2e 149 9 . . . cord-001273-plz1ja2e 150 1 Moreover moreover RB cord-001273-plz1ja2e 150 2 , , , cord-001273-plz1ja2e 150 3 distal distal JJ cord-001273-plz1ja2e 150 4 regulatory regulatory JJ cord-001273-plz1ja2e 150 5 elements element NNS cord-001273-plz1ja2e 150 6 modify modify VBP cord-001273-plz1ja2e 150 7 the the DT cord-001273-plz1ja2e 150 8 chromatin chromatin NN cord-001273-plz1ja2e 150 9 and and CC cord-001273-plz1ja2e 150 10 remodel remodel VB cord-001273-plz1ja2e 150 11 the the DT cord-001273-plz1ja2e 150 12 IFN IFN NNP cord-001273-plz1ja2e 150 13 - - HYPH cord-001273-plz1ja2e 150 14 γ γ NNP cord-001273-plz1ja2e 150 15 gene gene NN cord-001273-plz1ja2e 150 16 locus locus NN cord-001273-plz1ja2e 150 17 to to TO cord-001273-plz1ja2e 150 18 facilitate facilitate VB cord-001273-plz1ja2e 150 19 IFN IFN NNP cord-001273-plz1ja2e 150 20 - - HYPH cord-001273-plz1ja2e 150 21 γ γ NN cord-001273-plz1ja2e 150 22 production production NN cord-001273-plz1ja2e 151 1 ( ( -LRB- cord-001273-plz1ja2e 151 2 Wilson Wilson NNP cord-001273-plz1ja2e 151 3 et et NNP cord-001273-plz1ja2e 151 4 al al NNP cord-001273-plz1ja2e 151 5 . . NNP cord-001273-plz1ja2e 151 6 , , , cord-001273-plz1ja2e 151 7 2009 2009 CD cord-001273-plz1ja2e 151 8 ) ) -RRB- cord-001273-plz1ja2e 151 9 . . . cord-001273-plz1ja2e 152 1 IFNs ifn NNS cord-001273-plz1ja2e 152 2 are be VBP cord-001273-plz1ja2e 152 3 rapidly rapidly RB cord-001273-plz1ja2e 152 4 secreted secrete VBN cord-001273-plz1ja2e 152 5 upon upon IN cord-001273-plz1ja2e 152 6 infection infection NN cord-001273-plz1ja2e 152 7 and and CC cord-001273-plz1ja2e 152 8 then then RB cord-001273-plz1ja2e 152 9 bind bind VB cord-001273-plz1ja2e 152 10 to to IN cord-001273-plz1ja2e 152 11 their -PRON- PRP$ cord-001273-plz1ja2e 152 12 receptors receptor NNS cord-001273-plz1ja2e 152 13 on on IN cord-001273-plz1ja2e 152 14 the the DT cord-001273-plz1ja2e 152 15 surface surface NN cord-001273-plz1ja2e 152 16 of of IN cord-001273-plz1ja2e 152 17 target target NN cord-001273-plz1ja2e 152 18 cells cell NNS cord-001273-plz1ja2e 152 19 ( ( -LRB- cord-001273-plz1ja2e 152 20 Table table NN cord-001273-plz1ja2e 152 21 1 1 CD cord-001273-plz1ja2e 152 22 ) ) -RRB- cord-001273-plz1ja2e 152 23 . . . cord-001273-plz1ja2e 153 1 Type Type NNP cord-001273-plz1ja2e 153 2 I i NN cord-001273-plz1ja2e 153 3 - - HYPH cord-001273-plz1ja2e 153 4 IFNs ifns NN cord-001273-plz1ja2e 153 5 bind bind VBP cord-001273-plz1ja2e 153 6 the the DT cord-001273-plz1ja2e 153 7 ubiquitous ubiquitous JJ cord-001273-plz1ja2e 153 8 IFNAR IFNAR NNP cord-001273-plz1ja2e 153 9 receptor receptor NN cord-001273-plz1ja2e 153 10 , , , cord-001273-plz1ja2e 153 11 which which WDT cord-001273-plz1ja2e 153 12 consists consist VBZ cord-001273-plz1ja2e 153 13 of of IN cord-001273-plz1ja2e 153 14 two two CD cord-001273-plz1ja2e 153 15 chains chain NNS cord-001273-plz1ja2e 153 16 , , , cord-001273-plz1ja2e 153 17 IFNAR1 ifnar1 NN cord-001273-plz1ja2e 153 18 and and CC cord-001273-plz1ja2e 154 1 IFNAR2 IFNAR2 NNP cord-001273-plz1ja2e 155 1 ( ( -LRB- cord-001273-plz1ja2e 155 2 Piehler Piehler NNP cord-001273-plz1ja2e 155 3 et et NNP cord-001273-plz1ja2e 155 4 al al NNP cord-001273-plz1ja2e 155 5 . . NNP cord-001273-plz1ja2e 155 6 , , , cord-001273-plz1ja2e 155 7 2012 2012 CD cord-001273-plz1ja2e 155 8 ) ) -RRB- cord-001273-plz1ja2e 155 9 . . . cord-001273-plz1ja2e 156 1 Type Type NNP cord-001273-plz1ja2e 156 2 III III NNP cord-001273-plz1ja2e 156 3 - - HYPH cord-001273-plz1ja2e 156 4 IFNs ifns NN cord-001273-plz1ja2e 156 5 bind bind NN cord-001273-plz1ja2e 156 6 and and CC cord-001273-plz1ja2e 156 7 signal signal VB cord-001273-plz1ja2e 156 8 through through IN cord-001273-plz1ja2e 156 9 a a DT cord-001273-plz1ja2e 156 10 different different JJ cord-001273-plz1ja2e 156 11 receptor receptor NN cord-001273-plz1ja2e 156 12 complex complex NN cord-001273-plz1ja2e 156 13 , , , cord-001273-plz1ja2e 156 14 made make VBN cord-001273-plz1ja2e 156 15 of of IN cord-001273-plz1ja2e 156 16 two two CD cord-001273-plz1ja2e 156 17 chains chain NNS cord-001273-plz1ja2e 156 18 : : : cord-001273-plz1ja2e 156 19 IFNLR1 IFNLR1 NNP cord-001273-plz1ja2e 156 20 ( ( -LRB- cord-001273-plz1ja2e 156 21 also also RB cord-001273-plz1ja2e 156 22 known know VBN cord-001273-plz1ja2e 156 23 as as IN cord-001273-plz1ja2e 156 24 IL-28Rα IL-28Rα NNP cord-001273-plz1ja2e 156 25 ) ) -RRB- cord-001273-plz1ja2e 156 26 and and CC cord-001273-plz1ja2e 156 27 IL10R2 il10r2 NN cord-001273-plz1ja2e 156 28 . . . cord-001273-plz1ja2e 157 1 This this DT cord-001273-plz1ja2e 157 2 receptor receptor NN cord-001273-plz1ja2e 157 3 is be VBZ cord-001273-plz1ja2e 157 4 expressed express VBN cord-001273-plz1ja2e 157 5 primarily primarily RB cord-001273-plz1ja2e 157 6 by by IN cord-001273-plz1ja2e 157 7 epithelial epithelial JJ cord-001273-plz1ja2e 157 8 cells cell NNS cord-001273-plz1ja2e 157 9 and and CC cord-001273-plz1ja2e 157 10 hepatocytes hepatocyte NNS cord-001273-plz1ja2e 157 11 ( ( -LRB- cord-001273-plz1ja2e 157 12 Iversen Iversen NNP cord-001273-plz1ja2e 157 13 and and CC cord-001273-plz1ja2e 157 14 Paludan Paludan NNP cord-001273-plz1ja2e 157 15 , , , cord-001273-plz1ja2e 157 16 2010 2010 CD cord-001273-plz1ja2e 157 17 ) ) -RRB- cord-001273-plz1ja2e 157 18 . . . cord-001273-plz1ja2e 158 1 Thus thus RB cord-001273-plz1ja2e 158 2 , , , cord-001273-plz1ja2e 158 3 the the DT cord-001273-plz1ja2e 158 4 physiological physiological JJ cord-001273-plz1ja2e 158 5 roles role NNS cord-001273-plz1ja2e 158 6 of of IN cord-001273-plz1ja2e 158 7 type type NN cord-001273-plz1ja2e 158 8 I i NN cord-001273-plz1ja2e 158 9 - - HYPH cord-001273-plz1ja2e 158 10 and and CC cord-001273-plz1ja2e 158 11 type type NN cord-001273-plz1ja2e 158 12 III iii CD cord-001273-plz1ja2e 158 13 - - HYPH cord-001273-plz1ja2e 158 14 IFNs IFNs NNP cord-001273-plz1ja2e 158 15 are be VBP cord-001273-plz1ja2e 158 16 distinct distinct JJ cord-001273-plz1ja2e 158 17 because because IN cord-001273-plz1ja2e 158 18 of of IN cord-001273-plz1ja2e 158 19 the the DT cord-001273-plz1ja2e 158 20 different different JJ cord-001273-plz1ja2e 158 21 distribution distribution NN cord-001273-plz1ja2e 158 22 of of IN cord-001273-plz1ja2e 158 23 their -PRON- PRP$ cord-001273-plz1ja2e 158 24 receptors receptor NNS cord-001273-plz1ja2e 158 25 in in IN cord-001273-plz1ja2e 158 26 tissues tissue NNS cord-001273-plz1ja2e 158 27 , , , cord-001273-plz1ja2e 158 28 type type NN cord-001273-plz1ja2e 158 29 III III NNP cord-001273-plz1ja2e 158 30 - - HYPH cord-001273-plz1ja2e 158 31 IFNs ifns NN cord-001273-plz1ja2e 158 32 acting act VBG cord-001273-plz1ja2e 158 33 predominantly predominantly RB cord-001273-plz1ja2e 158 34 at at IN cord-001273-plz1ja2e 158 35 mucosal mucosal JJ cord-001273-plz1ja2e 158 36 surfaces surface NNS cord-001273-plz1ja2e 159 1 ( ( -LRB- cord-001273-plz1ja2e 159 2 Mordstein Mordstein NNP cord-001273-plz1ja2e 159 3 et et NNP cord-001273-plz1ja2e 159 4 al al NNP cord-001273-plz1ja2e 159 5 . . NNP cord-001273-plz1ja2e 159 6 , , , cord-001273-plz1ja2e 159 7 2010 2010 CD cord-001273-plz1ja2e 159 8 ; ; : cord-001273-plz1ja2e 159 9 Durbin Durbin NNP cord-001273-plz1ja2e 159 10 et et NNP cord-001273-plz1ja2e 159 11 al al NNP cord-001273-plz1ja2e 159 12 . . NNP cord-001273-plz1ja2e 159 13 , , , cord-001273-plz1ja2e 159 14 2013 2013 CD cord-001273-plz1ja2e 159 15 ) ) -RRB- cord-001273-plz1ja2e 159 16 . . . cord-001273-plz1ja2e 160 1 Type type NN cord-001273-plz1ja2e 160 2 I i NN cord-001273-plz1ja2e 160 3 - - HYPH cord-001273-plz1ja2e 160 4 and and CC cord-001273-plz1ja2e 160 5 type type NN cord-001273-plz1ja2e 160 6 III iii CD cord-001273-plz1ja2e 160 7 - - HYPH cord-001273-plz1ja2e 160 8 IFNs ifns NN cord-001273-plz1ja2e 160 9 use use VBP cord-001273-plz1ja2e 160 10 different different JJ cord-001273-plz1ja2e 160 11 receptors receptor NNS cord-001273-plz1ja2e 160 12 but but CC cord-001273-plz1ja2e 160 13 trigger trigger VB cord-001273-plz1ja2e 160 14 the the DT cord-001273-plz1ja2e 160 15 same same JJ cord-001273-plz1ja2e 160 16 JAK JAK NNP cord-001273-plz1ja2e 160 17 - - HYPH cord-001273-plz1ja2e 160 18 STAT stat NN cord-001273-plz1ja2e 160 19 signal signal NN cord-001273-plz1ja2e 160 20 transduction transduction NN cord-001273-plz1ja2e 160 21 cascade cascade NN cord-001273-plz1ja2e 160 22 involving involve VBG cord-001273-plz1ja2e 160 23 TYK2 TYK2 NNP cord-001273-plz1ja2e 160 24 , , , cord-001273-plz1ja2e 160 25 JAK1 JAK1 NNP cord-001273-plz1ja2e 160 26 , , , cord-001273-plz1ja2e 160 27 STAT1 stat1 XX cord-001273-plz1ja2e 160 28 , , , cord-001273-plz1ja2e 160 29 and and CC cord-001273-plz1ja2e 160 30 STAT2 STAT2 NNS cord-001273-plz1ja2e 160 31 albeit albeit IN cord-001273-plz1ja2e 160 32 with with IN cord-001273-plz1ja2e 160 33 different different JJ cord-001273-plz1ja2e 160 34 kinetics kinetic NNS cord-001273-plz1ja2e 160 35 ( ( -LRB- cord-001273-plz1ja2e 160 36 Figure figure NN cord-001273-plz1ja2e 160 37 2 2 CD cord-001273-plz1ja2e 160 38 ) ) -RRB- cord-001273-plz1ja2e 161 1 ( ( -LRB- cord-001273-plz1ja2e 161 2 Marcello Marcello NNP cord-001273-plz1ja2e 161 3 et et NNP cord-001273-plz1ja2e 161 4 al al NNP cord-001273-plz1ja2e 161 5 . . NNP cord-001273-plz1ja2e 161 6 , , , cord-001273-plz1ja2e 161 7 2006 2006 CD cord-001273-plz1ja2e 161 8 ) ) -RRB- cord-001273-plz1ja2e 161 9 . . . cord-001273-plz1ja2e 162 1 Ultimately ultimately RB cord-001273-plz1ja2e 162 2 , , , cord-001273-plz1ja2e 162 3 STAT1 stat1 XX cord-001273-plz1ja2e 162 4 , , , cord-001273-plz1ja2e 162 5 STAT2 STAT2 NNS cord-001273-plz1ja2e 162 6 , , , cord-001273-plz1ja2e 162 7 and and CC cord-001273-plz1ja2e 162 8 IRF9 IRF9 NNP cord-001273-plz1ja2e 162 9 form form VB cord-001273-plz1ja2e 162 10 a a DT cord-001273-plz1ja2e 162 11 transcription transcription NN cord-001273-plz1ja2e 162 12 factor factor NN cord-001273-plz1ja2e 162 13 complex complex NN cord-001273-plz1ja2e 162 14 , , , cord-001273-plz1ja2e 162 15 referred refer VBD cord-001273-plz1ja2e 162 16 to to IN cord-001273-plz1ja2e 162 17 as as IN cord-001273-plz1ja2e 162 18 ISGF3 ISGF3 NNP cord-001273-plz1ja2e 162 19 , , , cord-001273-plz1ja2e 162 20 which which WDT cord-001273-plz1ja2e 162 21 translocates translocate VBZ cord-001273-plz1ja2e 162 22 to to IN cord-001273-plz1ja2e 162 23 the the DT cord-001273-plz1ja2e 162 24 nucleus nucleus NN cord-001273-plz1ja2e 162 25 and and CC cord-001273-plz1ja2e 162 26 binds bind VBZ cord-001273-plz1ja2e 162 27 to to IN cord-001273-plz1ja2e 162 28 IFN IFN NNP cord-001273-plz1ja2e 162 29 - - HYPH cord-001273-plz1ja2e 162 30 stimulated stimulate VBN cord-001273-plz1ja2e 162 31 responsive responsive JJ cord-001273-plz1ja2e 162 32 elements element NNS cord-001273-plz1ja2e 162 33 ( ( -LRB- cord-001273-plz1ja2e 162 34 ISRE ISRE NNP cord-001273-plz1ja2e 162 35 ) ) -RRB- cord-001273-plz1ja2e 162 36 in in IN cord-001273-plz1ja2e 162 37 the the DT cord-001273-plz1ja2e 162 38 promoter promoter NN cord-001273-plz1ja2e 162 39 of of IN cord-001273-plz1ja2e 162 40 ISGs ISGs NNPS cord-001273-plz1ja2e 163 1 ( ( -LRB- cord-001273-plz1ja2e 163 2 Schindler Schindler NNP cord-001273-plz1ja2e 163 3 et et NNP cord-001273-plz1ja2e 163 4 al al NNP cord-001273-plz1ja2e 163 5 . . NNP cord-001273-plz1ja2e 163 6 , , , cord-001273-plz1ja2e 163 7 2007 2007 CD cord-001273-plz1ja2e 163 8 ) ) -RRB- cord-001273-plz1ja2e 163 9 . . . cord-001273-plz1ja2e 164 1 Type Type NNP cord-001273-plz1ja2e 164 2 II II NNP cord-001273-plz1ja2e 164 3 - - HYPH cord-001273-plz1ja2e 164 4 IFN IFN NNP cord-001273-plz1ja2e 164 5 , , , cord-001273-plz1ja2e 164 6 uses use VBZ cord-001273-plz1ja2e 164 7 a a DT cord-001273-plz1ja2e 164 8 heterodimeric heterodimeric JJ cord-001273-plz1ja2e 164 9 receptor receptor NN cord-001273-plz1ja2e 164 10 consisting consist VBG cord-001273-plz1ja2e 164 11 of of IN cord-001273-plz1ja2e 164 12 IFNγR1 IFNγR1 NNP cord-001273-plz1ja2e 164 13 and and CC cord-001273-plz1ja2e 164 14 IFNγR2 IFNγR2 NNP cord-001273-plz1ja2e 164 15 chains chain NNS cord-001273-plz1ja2e 164 16 , , , cord-001273-plz1ja2e 164 17 expressed express VBN cord-001273-plz1ja2e 164 18 by by IN cord-001273-plz1ja2e 164 19 many many JJ cord-001273-plz1ja2e 164 20 cell cell NN cord-001273-plz1ja2e 164 21 types type NNS cord-001273-plz1ja2e 164 22 ( ( -LRB- cord-001273-plz1ja2e 164 23 Bach Bach NNP cord-001273-plz1ja2e 164 24 et et NNP cord-001273-plz1ja2e 164 25 al al NNP cord-001273-plz1ja2e 164 26 . . NNP cord-001273-plz1ja2e 164 27 , , , cord-001273-plz1ja2e 164 28 1997 1997 CD cord-001273-plz1ja2e 164 29 ) ) -RRB- cord-001273-plz1ja2e 164 30 . . . cord-001273-plz1ja2e 165 1 IFN IFN NNP cord-001273-plz1ja2e 165 2 - - HYPH cord-001273-plz1ja2e 165 3 γ γ NNP cord-001273-plz1ja2e 165 4 activates activate VBZ cord-001273-plz1ja2e 165 5 JAK1 JAK1 NNP cord-001273-plz1ja2e 165 6 , , , cord-001273-plz1ja2e 165 7 JAK2 JAK2 NNP cord-001273-plz1ja2e 165 8 and and CC cord-001273-plz1ja2e 165 9 STAT1 stat1 XX cord-001273-plz1ja2e 165 10 , , , cord-001273-plz1ja2e 165 11 leading lead VBG cord-001273-plz1ja2e 165 12 to to IN cord-001273-plz1ja2e 165 13 transcription transcription NN cord-001273-plz1ja2e 165 14 of of IN cord-001273-plz1ja2e 165 15 genes gene NNS cord-001273-plz1ja2e 165 16 bearing bear VBG cord-001273-plz1ja2e 165 17 a a DT cord-001273-plz1ja2e 165 18 γ γ NN cord-001273-plz1ja2e 165 19 - - HYPH cord-001273-plz1ja2e 165 20 activation activation NN cord-001273-plz1ja2e 165 21 sequence sequence NN cord-001273-plz1ja2e 165 22 ( ( -LRB- cord-001273-plz1ja2e 165 23 GAS gas NN cord-001273-plz1ja2e 165 24 ) ) -RRB- cord-001273-plz1ja2e 165 25 in in IN cord-001273-plz1ja2e 165 26 their -PRON- PRP$ cord-001273-plz1ja2e 165 27 promoter promoter NN cord-001273-plz1ja2e 165 28 ( ( -LRB- cord-001273-plz1ja2e 165 29 Figure figure NN cord-001273-plz1ja2e 165 30 2 2 CD cord-001273-plz1ja2e 165 31 ) ) -RRB- cord-001273-plz1ja2e 165 32 ( ( -LRB- cord-001273-plz1ja2e 165 33 Schindler Schindler NNP cord-001273-plz1ja2e 165 34 et et NNP cord-001273-plz1ja2e 165 35 al al NNP cord-001273-plz1ja2e 165 36 . . NNP cord-001273-plz1ja2e 165 37 , , , cord-001273-plz1ja2e 165 38 2007 2007 CD cord-001273-plz1ja2e 165 39 ) ) -RRB- cord-001273-plz1ja2e 165 40 . . . cord-001273-plz1ja2e 166 1 MAMPs mamp NNS cord-001273-plz1ja2e 166 2 activate activate VBP cord-001273-plz1ja2e 166 3 PRRs prr NNS cord-001273-plz1ja2e 166 4 of of IN cord-001273-plz1ja2e 166 5 host host NN cord-001273-plz1ja2e 166 6 cells cell NNS cord-001273-plz1ja2e 166 7 such such JJ cord-001273-plz1ja2e 166 8 as as IN cord-001273-plz1ja2e 166 9 epithelial epithelial JJ cord-001273-plz1ja2e 166 10 cells cell NNS cord-001273-plz1ja2e 166 11 and and CC cord-001273-plz1ja2e 166 12 macrophages macrophage NNS cord-001273-plz1ja2e 166 13 ( ( -LRB- cord-001273-plz1ja2e 166 14 Figure figure NN cord-001273-plz1ja2e 166 15 1 1 CD cord-001273-plz1ja2e 166 16 ) ) -RRB- cord-001273-plz1ja2e 166 17 . . . cord-001273-plz1ja2e 167 1 Infection infection NN cord-001273-plz1ja2e 167 2 induces induce VBZ cord-001273-plz1ja2e 167 3 a a DT cord-001273-plz1ja2e 167 4 robust robust JJ cord-001273-plz1ja2e 167 5 type type NN cord-001273-plz1ja2e 167 6 I i NN cord-001273-plz1ja2e 167 7 - - HYPH cord-001273-plz1ja2e 167 8 IFN IFN NNP cord-001273-plz1ja2e 167 9 response response NN cord-001273-plz1ja2e 167 10 . . . cord-001273-plz1ja2e 168 1 In in IN cord-001273-plz1ja2e 168 2 mice mouse NNS cord-001273-plz1ja2e 168 3 , , , cord-001273-plz1ja2e 168 4 macrophages macrophage NNS cord-001273-plz1ja2e 168 5 have have VBP cord-001273-plz1ja2e 168 6 been be VBN cord-001273-plz1ja2e 168 7 identified identify VBN cord-001273-plz1ja2e 168 8 as as IN cord-001273-plz1ja2e 168 9 the the DT cord-001273-plz1ja2e 168 10 major major JJ cord-001273-plz1ja2e 168 11 source source NN cord-001273-plz1ja2e 168 12 of of IN cord-001273-plz1ja2e 168 13 IFN IFN NNP cord-001273-plz1ja2e 168 14 - - HYPH cord-001273-plz1ja2e 168 15 β β NNP cord-001273-plz1ja2e 168 16 ( ( -LRB- cord-001273-plz1ja2e 168 17 Stockinger Stockinger NNP cord-001273-plz1ja2e 168 18 et et NNP cord-001273-plz1ja2e 168 19 al al NNP cord-001273-plz1ja2e 168 20 . . NNP cord-001273-plz1ja2e 168 21 , , , cord-001273-plz1ja2e 168 22 2009 2009 CD cord-001273-plz1ja2e 168 23 ) ) -RRB- cord-001273-plz1ja2e 168 24 . . . cord-001273-plz1ja2e 169 1 In in IN cord-001273-plz1ja2e 169 2 vitro vitro FW cord-001273-plz1ja2e 169 3 , , , cord-001273-plz1ja2e 169 4 IFN IFN NNP cord-001273-plz1ja2e 169 5 - - HYPH cord-001273-plz1ja2e 169 6 β β NN cord-001273-plz1ja2e 169 7 production production NN cord-001273-plz1ja2e 169 8 by by IN cord-001273-plz1ja2e 169 9 bone bone NN cord-001273-plz1ja2e 169 10 - - HYPH cord-001273-plz1ja2e 169 11 marrow marrow NN cord-001273-plz1ja2e 169 12 - - HYPH cord-001273-plz1ja2e 169 13 derived derive VBN cord-001273-plz1ja2e 169 14 murine murine JJ cord-001273-plz1ja2e 169 15 macrophages macrophage NNS cord-001273-plz1ja2e 169 16 has have VBZ cord-001273-plz1ja2e 169 17 been be VBN cord-001273-plz1ja2e 169 18 shown show VBN cord-001273-plz1ja2e 169 19 to to TO cord-001273-plz1ja2e 169 20 require require VB cord-001273-plz1ja2e 169 21 bacterial bacterial JJ cord-001273-plz1ja2e 169 22 escape escape NN cord-001273-plz1ja2e 169 23 from from IN cord-001273-plz1ja2e 169 24 the the DT cord-001273-plz1ja2e 169 25 phagosome phagosome NN cord-001273-plz1ja2e 169 26 and and CC cord-001273-plz1ja2e 169 27 activation activation NN cord-001273-plz1ja2e 169 28 of of IN cord-001273-plz1ja2e 169 29 cytosolic cytosolic JJ cord-001273-plz1ja2e 169 30 surveillance surveillance NN cord-001273-plz1ja2e 169 31 pathways pathway NNS cord-001273-plz1ja2e 169 32 ( ( -LRB- cord-001273-plz1ja2e 169 33 O'Riordan O'Riordan NNP cord-001273-plz1ja2e 169 34 et et FW cord-001273-plz1ja2e 169 35 al al NNP cord-001273-plz1ja2e 169 36 . . NNP cord-001273-plz1ja2e 169 37 , , , cord-001273-plz1ja2e 169 38 2002 2002 CD cord-001273-plz1ja2e 169 39 ) ) -RRB- cord-001273-plz1ja2e 169 40 . . . cord-001273-plz1ja2e 170 1 Induction induction NN cord-001273-plz1ja2e 170 2 of of IN cord-001273-plz1ja2e 170 3 IFN IFN NNP cord-001273-plz1ja2e 170 4 - - HYPH cord-001273-plz1ja2e 170 5 β β NNP cord-001273-plz1ja2e 170 6 depends depend VBZ cord-001273-plz1ja2e 170 7 on on IN cord-001273-plz1ja2e 170 8 the the DT cord-001273-plz1ja2e 170 9 adaptor adaptor NN cord-001273-plz1ja2e 170 10 protein protein NN cord-001273-plz1ja2e 170 11 STING STING NNP cord-001273-plz1ja2e 170 12 and and CC cord-001273-plz1ja2e 170 13 the the DT cord-001273-plz1ja2e 170 14 cytosolic cytosolic JJ cord-001273-plz1ja2e 170 15 PRR PRR NNP cord-001273-plz1ja2e 170 16 DDX41 ddx41 NN cord-001273-plz1ja2e 170 17 , , , cord-001273-plz1ja2e 170 18 which which WDT cord-001273-plz1ja2e 170 19 are be VBP cord-001273-plz1ja2e 170 20 activated activate VBN cord-001273-plz1ja2e 170 21 by by IN cord-001273-plz1ja2e 170 22 bacterial bacterial JJ cord-001273-plz1ja2e 170 23 secondary secondary JJ cord-001273-plz1ja2e 170 24 messengers messenger NNS cord-001273-plz1ja2e 170 25 c c NN cord-001273-plz1ja2e 170 26 - - HYPH cord-001273-plz1ja2e 170 27 di di NNP cord-001273-plz1ja2e 170 28 - - HYPH cord-001273-plz1ja2e 170 29 AMP amp NN cord-001273-plz1ja2e 170 30 and and CC cord-001273-plz1ja2e 170 31 c c NN cord-001273-plz1ja2e 170 32 - - HYPH cord-001273-plz1ja2e 170 33 di di NNP cord-001273-plz1ja2e 170 34 - - HYPH cord-001273-plz1ja2e 170 35 GMP GMP NNP cord-001273-plz1ja2e 170 36 and and CC cord-001273-plz1ja2e 170 37 by by IN cord-001273-plz1ja2e 170 38 bacterial bacterial JJ cord-001273-plz1ja2e 170 39 DNA DNA NNP cord-001273-plz1ja2e 170 40 ( ( -LRB- cord-001273-plz1ja2e 170 41 Woodward Woodward NNP cord-001273-plz1ja2e 170 42 et et NNP cord-001273-plz1ja2e 170 43 al al NNP cord-001273-plz1ja2e 170 44 . . NNP cord-001273-plz1ja2e 170 45 , , , cord-001273-plz1ja2e 170 46 2010 2010 CD cord-001273-plz1ja2e 170 47 ; ; : cord-001273-plz1ja2e 170 48 Burdette Burdette NNP cord-001273-plz1ja2e 170 49 et et NNP cord-001273-plz1ja2e 170 50 al al NNP cord-001273-plz1ja2e 170 51 . . . cord-001273-plz1ja2e 171 1 , , , cord-001273-plz1ja2e 171 2 2011 2011 CD cord-001273-plz1ja2e 171 3 ; ; : cord-001273-plz1ja2e 171 4 Sauer Sauer NNP cord-001273-plz1ja2e 171 5 et et NNP cord-001273-plz1ja2e 171 6 al al NNP cord-001273-plz1ja2e 171 7 . . NNP cord-001273-plz1ja2e 171 8 , , , cord-001273-plz1ja2e 171 9 2011 2011 CD cord-001273-plz1ja2e 171 10 ; ; : cord-001273-plz1ja2e 171 11 Parvatiyar Parvatiyar NNP cord-001273-plz1ja2e 171 12 et et NNP cord-001273-plz1ja2e 171 13 al al NNP cord-001273-plz1ja2e 171 14 . . NNP cord-001273-plz1ja2e 171 15 , , , cord-001273-plz1ja2e 171 16 2012 2012 CD cord-001273-plz1ja2e 171 17 ; ; : cord-001273-plz1ja2e 171 18 Archer Archer NNP cord-001273-plz1ja2e 171 19 et et NNP cord-001273-plz1ja2e 171 20 al al NNP cord-001273-plz1ja2e 171 21 . . NNP cord-001273-plz1ja2e 171 22 , , , cord-001273-plz1ja2e 171 23 2014 2014 CD cord-001273-plz1ja2e 171 24 ) ) -RRB- cord-001273-plz1ja2e 171 25 . . . cord-001273-plz1ja2e 172 1 STING STING NNP cord-001273-plz1ja2e 172 2 is be VBZ cord-001273-plz1ja2e 172 3 a a DT cord-001273-plz1ja2e 172 4 direct direct JJ cord-001273-plz1ja2e 172 5 receptor receptor NN cord-001273-plz1ja2e 172 6 for for IN cord-001273-plz1ja2e 172 7 cyclic cyclic JJ cord-001273-plz1ja2e 172 8 - - HYPH cord-001273-plz1ja2e 172 9 dinucleotides dinucleotide NNS cord-001273-plz1ja2e 172 10 , , , cord-001273-plz1ja2e 172 11 including include VBG cord-001273-plz1ja2e 172 12 the the DT cord-001273-plz1ja2e 172 13 cellular cellular JJ cord-001273-plz1ja2e 172 14 second second JJ cord-001273-plz1ja2e 172 15 messenger messenger NN cord-001273-plz1ja2e 172 16 cyclic cyclic JJ cord-001273-plz1ja2e 172 17 GMP GMP NNP cord-001273-plz1ja2e 172 18 - - HYPH cord-001273-plz1ja2e 172 19 AMP AMP NNP cord-001273-plz1ja2e 172 20 ( ( -LRB- cord-001273-plz1ja2e 172 21 cGAMP cGAMP NNP cord-001273-plz1ja2e 172 22 ) ) -RRB- cord-001273-plz1ja2e 172 23 which which WDT cord-001273-plz1ja2e 172 24 is be VBZ cord-001273-plz1ja2e 172 25 produced produce VBN cord-001273-plz1ja2e 172 26 by by IN cord-001273-plz1ja2e 172 27 the the DT cord-001273-plz1ja2e 172 28 cytosolic cytosolic JJ cord-001273-plz1ja2e 172 29 sensor sensor NN cord-001273-plz1ja2e 172 30 cGAMP cgamp FW cord-001273-plz1ja2e 172 31 synthase synthase NN cord-001273-plz1ja2e 172 32 ( ( -LRB- cord-001273-plz1ja2e 172 33 cGAS cga VBG cord-001273-plz1ja2e 172 34 ) ) -RRB- cord-001273-plz1ja2e 172 35 upon upon IN cord-001273-plz1ja2e 172 36 interaction interaction NN cord-001273-plz1ja2e 172 37 with with IN cord-001273-plz1ja2e 172 38 microbial microbial JJ cord-001273-plz1ja2e 172 39 DNA dna NN cord-001273-plz1ja2e 172 40 ( ( -LRB- cord-001273-plz1ja2e 172 41 Ablasser Ablasser NNP cord-001273-plz1ja2e 172 42 et et FW cord-001273-plz1ja2e 172 43 al al NNP cord-001273-plz1ja2e 172 44 . . NNP cord-001273-plz1ja2e 172 45 , , , cord-001273-plz1ja2e 172 46 2013 2013 CD cord-001273-plz1ja2e 172 47 ; ; : cord-001273-plz1ja2e 172 48 Gao Gao NNP cord-001273-plz1ja2e 172 49 et et NNP cord-001273-plz1ja2e 172 50 al al NNP cord-001273-plz1ja2e 172 51 . . NNP cord-001273-plz1ja2e 172 52 , , , cord-001273-plz1ja2e 172 53 2013 2013 CD cord-001273-plz1ja2e 172 54 ; ; : cord-001273-plz1ja2e 172 55 Wu Wu NNP cord-001273-plz1ja2e 172 56 et et NNP cord-001273-plz1ja2e 172 57 al al NNP cord-001273-plz1ja2e 172 58 . . NNP cord-001273-plz1ja2e 172 59 , , , cord-001273-plz1ja2e 172 60 2013 2013 CD cord-001273-plz1ja2e 172 61 ; ; : cord-001273-plz1ja2e 172 62 Sun Sun NNP cord-001273-plz1ja2e 172 63 et et NNP cord-001273-plz1ja2e 172 64 al al NNP cord-001273-plz1ja2e 172 65 . . NNP cord-001273-plz1ja2e 172 66 , , , cord-001273-plz1ja2e 172 67 2013 2013 CD cord-001273-plz1ja2e 172 68 ; ; : cord-001273-plz1ja2e 172 69 Schoggins Schoggins NNP cord-001273-plz1ja2e 172 70 et et NNP cord-001273-plz1ja2e 172 71 al al NNP cord-001273-plz1ja2e 172 72 . . NNP cord-001273-plz1ja2e 172 73 , , , cord-001273-plz1ja2e 172 74 2014 2014 CD cord-001273-plz1ja2e 172 75 ) ) -RRB- cord-001273-plz1ja2e 172 76 . . . cord-001273-plz1ja2e 173 1 Interestingly interestingly RB cord-001273-plz1ja2e 173 2 , , , cord-001273-plz1ja2e 173 3 type type NN cord-001273-plz1ja2e 173 4 I I NNP cord-001273-plz1ja2e 173 5 - - HYPH cord-001273-plz1ja2e 173 6 IFN IFN NNP cord-001273-plz1ja2e 173 7 production production NN cord-001273-plz1ja2e 173 8 requires require VBZ cord-001273-plz1ja2e 173 9 activation activation NN cord-001273-plz1ja2e 173 10 of of IN cord-001273-plz1ja2e 173 11 the the DT cord-001273-plz1ja2e 173 12 RIG rig NN cord-001273-plz1ja2e 173 13 - - : cord-001273-plz1ja2e 173 14 I -PRON- PRP cord-001273-plz1ja2e 173 15 helicase helicase NN cord-001273-plz1ja2e 173 16 by by IN cord-001273-plz1ja2e 173 17 Listeria Listeria NNP cord-001273-plz1ja2e 173 18 RNA RNA NNP cord-001273-plz1ja2e 173 19 in in IN cord-001273-plz1ja2e 173 20 non non JJ cord-001273-plz1ja2e 173 21 - - JJ cord-001273-plz1ja2e 173 22 immune immune JJ cord-001273-plz1ja2e 173 23 cells cell NNS cord-001273-plz1ja2e 173 24 lacking lack VBG cord-001273-plz1ja2e 173 25 a a DT cord-001273-plz1ja2e 173 26 functional functional JJ cord-001273-plz1ja2e 173 27 STING sting NN cord-001273-plz1ja2e 173 28 signaling signal VBG cord-001273-plz1ja2e 173 29 pathway pathway NN cord-001273-plz1ja2e 173 30 ( ( -LRB- cord-001273-plz1ja2e 174 1 Abdullah Abdullah NNP cord-001273-plz1ja2e 174 2 et et NNP cord-001273-plz1ja2e 174 3 al al NNP cord-001273-plz1ja2e 174 4 . . . cord-001273-plz1ja2e 175 1 , , , cord-001273-plz1ja2e 175 2 2012 2012 CD cord-001273-plz1ja2e 175 3 ; ; : cord-001273-plz1ja2e 175 4 Hagmann Hagmann NNP cord-001273-plz1ja2e 175 5 et et NNP cord-001273-plz1ja2e 175 6 al al NNP cord-001273-plz1ja2e 175 7 . . NNP cord-001273-plz1ja2e 175 8 , , , cord-001273-plz1ja2e 175 9 2013 2013 CD cord-001273-plz1ja2e 175 10 ) ) -RRB- cord-001273-plz1ja2e 175 11 . . . cord-001273-plz1ja2e 176 1 Another another DT cord-001273-plz1ja2e 176 2 cytosolic cytosolic JJ cord-001273-plz1ja2e 176 3 PRR PRR NNP cord-001273-plz1ja2e 176 4 , , , cord-001273-plz1ja2e 176 5 the the DT cord-001273-plz1ja2e 176 6 leucine leucine NN cord-001273-plz1ja2e 176 7 - - HYPH cord-001273-plz1ja2e 176 8 rich rich JJ cord-001273-plz1ja2e 176 9 repeat repeat NN cord-001273-plz1ja2e 176 10 - - HYPH cord-001273-plz1ja2e 176 11 containing contain VBG cord-001273-plz1ja2e 176 12 protein protein NN cord-001273-plz1ja2e 176 13 LRRFIP1 LRRFIP1 NNP cord-001273-plz1ja2e 176 14 , , , cord-001273-plz1ja2e 176 15 has have VBZ cord-001273-plz1ja2e 176 16 also also RB cord-001273-plz1ja2e 176 17 been be VBN cord-001273-plz1ja2e 176 18 implicated implicate VBN cord-001273-plz1ja2e 176 19 in in IN cord-001273-plz1ja2e 176 20 IFN IFN NNP cord-001273-plz1ja2e 176 21 - - HYPH cord-001273-plz1ja2e 176 22 β β NN cord-001273-plz1ja2e 176 23 production production NN cord-001273-plz1ja2e 176 24 by by IN cord-001273-plz1ja2e 176 25 mouse mouse NN cord-001273-plz1ja2e 176 26 primary primary JJ cord-001273-plz1ja2e 176 27 peritoneal peritoneal JJ cord-001273-plz1ja2e 176 28 macrophages macrophage NNS cord-001273-plz1ja2e 176 29 in in IN cord-001273-plz1ja2e 176 30 response response NN cord-001273-plz1ja2e 176 31 to to IN cord-001273-plz1ja2e 176 32 Listeria Listeria NNP cord-001273-plz1ja2e 176 33 infection infection NN cord-001273-plz1ja2e 176 34 , , , cord-001273-plz1ja2e 176 35 possibly possibly RB cord-001273-plz1ja2e 176 36 by by IN cord-001273-plz1ja2e 176 37 sensing sense VBG cord-001273-plz1ja2e 176 38 double double RB cord-001273-plz1ja2e 176 39 stranded strand VBN cord-001273-plz1ja2e 176 40 DNA DNA NNP cord-001273-plz1ja2e 176 41 and and CC cord-001273-plz1ja2e 176 42 RNA RNA NNP cord-001273-plz1ja2e 177 1 ( ( -LRB- cord-001273-plz1ja2e 177 2 Yang Yang NNP cord-001273-plz1ja2e 177 3 et et NNP cord-001273-plz1ja2e 177 4 al al NNP cord-001273-plz1ja2e 177 5 . . NNP cord-001273-plz1ja2e 177 6 , , , cord-001273-plz1ja2e 177 7 2010 2010 CD cord-001273-plz1ja2e 177 8 ) ) -RRB- cord-001273-plz1ja2e 177 9 . . . cord-001273-plz1ja2e 178 1 While while IN cord-001273-plz1ja2e 178 2 production production NN cord-001273-plz1ja2e 178 3 of of IN cord-001273-plz1ja2e 178 4 IFN IFN NNP cord-001273-plz1ja2e 178 5 - - HYPH cord-001273-plz1ja2e 178 6 β β NNP cord-001273-plz1ja2e 178 7 in in IN cord-001273-plz1ja2e 178 8 response response NN cord-001273-plz1ja2e 178 9 to to IN cord-001273-plz1ja2e 178 10 Listeria Listeria NNP cord-001273-plz1ja2e 178 11 infection infection NN cord-001273-plz1ja2e 178 12 is be VBZ cord-001273-plz1ja2e 178 13 independent independent JJ cord-001273-plz1ja2e 178 14 from from IN cord-001273-plz1ja2e 178 15 TLRs TLRs NNP cord-001273-plz1ja2e 178 16 in in IN cord-001273-plz1ja2e 178 17 bone bone NN cord-001273-plz1ja2e 178 18 - - HYPH cord-001273-plz1ja2e 178 19 marrowderived marrowderive VBN cord-001273-plz1ja2e 178 20 macrophages macrophage NNS cord-001273-plz1ja2e 178 21 ( ( -LRB- cord-001273-plz1ja2e 178 22 McCaffrey McCaffrey NNP cord-001273-plz1ja2e 178 23 et et NNP cord-001273-plz1ja2e 178 24 al al NNP cord-001273-plz1ja2e 178 25 . . NNP cord-001273-plz1ja2e 178 26 , , , cord-001273-plz1ja2e 178 27 2004 2004 CD cord-001273-plz1ja2e 178 28 ; ; : cord-001273-plz1ja2e 178 29 Stockinger Stockinger NNP cord-001273-plz1ja2e 178 30 et et NNP cord-001273-plz1ja2e 178 31 al al NNP cord-001273-plz1ja2e 178 32 . . NNP cord-001273-plz1ja2e 178 33 , , , cord-001273-plz1ja2e 178 34 2004 2004 CD cord-001273-plz1ja2e 178 35 ; ; : cord-001273-plz1ja2e 179 1 O'Connell O'Connell NNP cord-001273-plz1ja2e 179 2 et et NNP cord-001273-plz1ja2e 179 3 al al NNP cord-001273-plz1ja2e 179 4 . . NNP cord-001273-plz1ja2e 179 5 , , , cord-001273-plz1ja2e 179 6 2005 2005 CD cord-001273-plz1ja2e 179 7 ) ) -RRB- cord-001273-plz1ja2e 179 8 , , , cord-001273-plz1ja2e 179 9 TLR-2 TLR-2 NNP cord-001273-plz1ja2e 179 10 contributes contribute VBZ cord-001273-plz1ja2e 179 11 significantly significantly RB cord-001273-plz1ja2e 179 12 to to IN cord-001273-plz1ja2e 179 13 IFN IFN NNP cord-001273-plz1ja2e 179 14 - - HYPH cord-001273-plz1ja2e 179 15 β β NN cord-001273-plz1ja2e 179 16 secretion secretion NN cord-001273-plz1ja2e 179 17 by by IN cord-001273-plz1ja2e 179 18 peritoneal peritoneal JJ cord-001273-plz1ja2e 179 19 macrophages macrophage NNS cord-001273-plz1ja2e 179 20 , , , cord-001273-plz1ja2e 179 21 suggesting suggest VBG cord-001273-plz1ja2e 179 22 that that IN cord-001273-plz1ja2e 179 23 specific specific JJ cord-001273-plz1ja2e 179 24 macrophage macrophage NN cord-001273-plz1ja2e 179 25 populations population NNS cord-001273-plz1ja2e 179 26 have have VBP cord-001273-plz1ja2e 179 27 evolved evolve VBN cord-001273-plz1ja2e 179 28 different different JJ cord-001273-plz1ja2e 179 29 recognition recognition NN cord-001273-plz1ja2e 179 30 strategies strategy NNS cord-001273-plz1ja2e 179 31 in in IN cord-001273-plz1ja2e 179 32 response response NN cord-001273-plz1ja2e 179 33 to to IN cord-001273-plz1ja2e 179 34 Listeria Listeria NNP cord-001273-plz1ja2e 179 35 infection infection NN cord-001273-plz1ja2e 180 1 ( ( -LRB- cord-001273-plz1ja2e 180 2 Aubry Aubry NNP cord-001273-plz1ja2e 180 3 et et NNP cord-001273-plz1ja2e 180 4 al al NNP cord-001273-plz1ja2e 180 5 . . NNP cord-001273-plz1ja2e 180 6 , , , cord-001273-plz1ja2e 180 7 2012 2012 CD cord-001273-plz1ja2e 180 8 ) ) -RRB- cord-001273-plz1ja2e 180 9 . . . cord-001273-plz1ja2e 181 1 Listeria listeria NN cord-001273-plz1ja2e 181 2 infection infection NN cord-001273-plz1ja2e 181 3 has have VBZ cord-001273-plz1ja2e 181 4 recently recently RB cord-001273-plz1ja2e 181 5 been be VBN cord-001273-plz1ja2e 181 6 shown show VBN cord-001273-plz1ja2e 181 7 to to TO cord-001273-plz1ja2e 181 8 induce induce VB cord-001273-plz1ja2e 181 9 type type NN cord-001273-plz1ja2e 181 10 III III NNP cord-001273-plz1ja2e 181 11 - - HYPH cord-001273-plz1ja2e 181 12 IFN IFN NNP cord-001273-plz1ja2e 181 13 gene gene NN cord-001273-plz1ja2e 181 14 expression expression NN cord-001273-plz1ja2e 181 15 in in IN cord-001273-plz1ja2e 181 16 cells cell NNS cord-001273-plz1ja2e 181 17 of of IN cord-001273-plz1ja2e 181 18 epithelial epithelial JJ cord-001273-plz1ja2e 181 19 origin origin NN cord-001273-plz1ja2e 181 20 , , , cord-001273-plz1ja2e 181 21 such such JJ cord-001273-plz1ja2e 181 22 as as IN cord-001273-plz1ja2e 181 23 intestinal intestinal JJ cord-001273-plz1ja2e 181 24 and and CC cord-001273-plz1ja2e 181 25 trophoblast trophoblast NN cord-001273-plz1ja2e 181 26 cells cell NNS cord-001273-plz1ja2e 181 27 and and CC cord-001273-plz1ja2e 181 28 hepatocytes hepatocyte NNS cord-001273-plz1ja2e 181 29 ( ( -LRB- cord-001273-plz1ja2e 181 30 Lebreton Lebreton NNP cord-001273-plz1ja2e 181 31 et et FW cord-001273-plz1ja2e 181 32 al al NNP cord-001273-plz1ja2e 181 33 . . NNP cord-001273-plz1ja2e 181 34 , , , cord-001273-plz1ja2e 181 35 2011 2011 CD cord-001273-plz1ja2e 181 36 ; ; : cord-001273-plz1ja2e 181 37 Bierne Bierne NNP cord-001273-plz1ja2e 181 38 et et NNP cord-001273-plz1ja2e 181 39 al al NNP cord-001273-plz1ja2e 181 40 . . NNP cord-001273-plz1ja2e 181 41 , , , cord-001273-plz1ja2e 181 42 2012 2012 CD cord-001273-plz1ja2e 181 43 ) ) -RRB- cord-001273-plz1ja2e 181 44 . . . cord-001273-plz1ja2e 182 1 Similar similar JJ cord-001273-plz1ja2e 182 2 to to TO cord-001273-plz1ja2e 182 3 type type VB cord-001273-plz1ja2e 182 4 I I NNP cord-001273-plz1ja2e 182 5 - - HYPH cord-001273-plz1ja2e 182 6 IFN IFN NNP cord-001273-plz1ja2e 182 7 , , , cord-001273-plz1ja2e 183 1 type type NNP cord-001273-plz1ja2e 183 2 III III NNP cord-001273-plz1ja2e 183 3 - - HYPH cord-001273-plz1ja2e 183 4 IFN IFN NNP cord-001273-plz1ja2e 183 5 induction induction NN cord-001273-plz1ja2e 183 6 is be VBZ cord-001273-plz1ja2e 183 7 triggered trigger VBN cord-001273-plz1ja2e 183 8 by by IN cord-001273-plz1ja2e 183 9 intracellular intracellular JJ cord-001273-plz1ja2e 183 10 Listeria Listeria NNP cord-001273-plz1ja2e 183 11 . . . cord-001273-plz1ja2e 184 1 Listeria listeria NN cord-001273-plz1ja2e 184 2 infection infection NN cord-001273-plz1ja2e 184 3 also also RB cord-001273-plz1ja2e 184 4 triggers trigger VBZ cord-001273-plz1ja2e 184 5 a a DT cord-001273-plz1ja2e 184 6 rapid rapid JJ cord-001273-plz1ja2e 184 7 and and CC cord-001273-plz1ja2e 184 8 robust robust JJ cord-001273-plz1ja2e 184 9 IFN IFN NNP cord-001273-plz1ja2e 184 10 - - HYPH cord-001273-plz1ja2e 184 11 γ γ NN cord-001273-plz1ja2e 184 12 response response NN cord-001273-plz1ja2e 184 13 . . . cord-001273-plz1ja2e 185 1 After after IN cord-001273-plz1ja2e 185 2 intravenous intravenous JJ cord-001273-plz1ja2e 185 3 infection infection NN cord-001273-plz1ja2e 185 4 of of IN cord-001273-plz1ja2e 185 5 mice mouse NNS cord-001273-plz1ja2e 185 6 with with IN cord-001273-plz1ja2e 185 7 L. L. NNP cord-001273-plz1ja2e 185 8 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 185 9 , , , cord-001273-plz1ja2e 185 10 NK NK NNP cord-001273-plz1ja2e 185 11 and and CC cord-001273-plz1ja2e 185 12 T t NN cord-001273-plz1ja2e 185 13 cells cell NNS cord-001273-plz1ja2e 185 14 are be VBP cord-001273-plz1ja2e 185 15 the the DT cord-001273-plz1ja2e 185 16 main main JJ cord-001273-plz1ja2e 185 17 sources source NNS cord-001273-plz1ja2e 185 18 of of IN cord-001273-plz1ja2e 185 19 IFN IFN NNP cord-001273-plz1ja2e 185 20 - - HYPH cord-001273-plz1ja2e 185 21 γ γ NNP cord-001273-plz1ja2e 185 22 ( ( -LRB- cord-001273-plz1ja2e 185 23 Thale Thale NNP cord-001273-plz1ja2e 185 24 and and CC cord-001273-plz1ja2e 185 25 Kiderlen Kiderlen NNP cord-001273-plz1ja2e 185 26 , , , cord-001273-plz1ja2e 185 27 2005 2005 CD cord-001273-plz1ja2e 185 28 ; ; : cord-001273-plz1ja2e 185 29 Bou Bou NNP cord-001273-plz1ja2e 185 30 Ghanem Ghanem NNP cord-001273-plz1ja2e 185 31 et et FW cord-001273-plz1ja2e 185 32 al al NNP cord-001273-plz1ja2e 185 33 . . NNP cord-001273-plz1ja2e 185 34 , , , cord-001273-plz1ja2e 185 35 2009 2009 CD cord-001273-plz1ja2e 185 36 ) ) -RRB- cord-001273-plz1ja2e 185 37 . . . cord-001273-plz1ja2e 186 1 IFN IFN NNP cord-001273-plz1ja2e 186 2 - - HYPH cord-001273-plz1ja2e 186 3 γ γ NNP cord-001273-plz1ja2e 186 4 producing produce VBG cord-001273-plz1ja2e 186 5 V1δ v1δ XX cord-001273-plz1ja2e 187 1 + + CC cord-001273-plz1ja2e 187 2 -γδ -γδ : cord-001273-plz1ja2e 187 3 T t NN cord-001273-plz1ja2e 187 4 cells cell NNS cord-001273-plz1ja2e 187 5 are be VBP cord-001273-plz1ja2e 187 6 other other JJ cord-001273-plz1ja2e 187 7 murine murine JJ cord-001273-plz1ja2e 187 8 immune immune JJ cord-001273-plz1ja2e 187 9 cells cell NNS cord-001273-plz1ja2e 187 10 induced induce VBN cord-001273-plz1ja2e 187 11 at at IN cord-001273-plz1ja2e 187 12 an an DT cord-001273-plz1ja2e 187 13 early early JJ cord-001273-plz1ja2e 187 14 stage stage NN cord-001273-plz1ja2e 187 15 of of IN cord-001273-plz1ja2e 187 16 Listeria Listeria NNP cord-001273-plz1ja2e 187 17 infection infection NN cord-001273-plz1ja2e 187 18 in in IN cord-001273-plz1ja2e 187 19 mice mouse NNS cord-001273-plz1ja2e 187 20 inoculated inoculate VBD cord-001273-plz1ja2e 187 21 intraperitoneally intraperitoneally RB cord-001273-plz1ja2e 188 1 ( ( -LRB- cord-001273-plz1ja2e 188 2 Hamada Hamada NNP cord-001273-plz1ja2e 188 3 et et NNP cord-001273-plz1ja2e 188 4 al al NNP cord-001273-plz1ja2e 188 5 . . NNP cord-001273-plz1ja2e 188 6 , , , cord-001273-plz1ja2e 188 7 2008 2008 CD cord-001273-plz1ja2e 188 8 ) ) -RRB- cord-001273-plz1ja2e 188 9 . . . cord-001273-plz1ja2e 189 1 Using use VBG cord-001273-plz1ja2e 189 2 oral oral JJ cord-001273-plz1ja2e 189 3 infection infection NN cord-001273-plz1ja2e 189 4 of of IN cord-001273-plz1ja2e 189 5 mice mouse NNS cord-001273-plz1ja2e 189 6 , , , cord-001273-plz1ja2e 189 7 the the DT cord-001273-plz1ja2e 189 8 natural natural JJ cord-001273-plz1ja2e 189 9 route route NN cord-001273-plz1ja2e 189 10 of of IN cord-001273-plz1ja2e 189 11 infection infection NN cord-001273-plz1ja2e 189 12 in in IN cord-001273-plz1ja2e 189 13 permissive permissive JJ cord-001273-plz1ja2e 189 14 hosts host NNS cord-001273-plz1ja2e 189 15 , , , cord-001273-plz1ja2e 189 16 L. L. NNP cord-001273-plz1ja2e 189 17 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 189 18 has have VBZ cord-001273-plz1ja2e 189 19 been be VBN cord-001273-plz1ja2e 189 20 shown show VBN cord-001273-plz1ja2e 189 21 to to TO cord-001273-plz1ja2e 189 22 induce induce VB cord-001273-plz1ja2e 189 23 IFN IFN NNP cord-001273-plz1ja2e 189 24 - - HYPH cord-001273-plz1ja2e 189 25 γ γ NN cord-001273-plz1ja2e 189 26 production production NN cord-001273-plz1ja2e 189 27 by by IN cord-001273-plz1ja2e 189 28 intraepithelial intraepithelial JJ cord-001273-plz1ja2e 189 29 lymphocytes lymphocyte NNS cord-001273-plz1ja2e 189 30 of of IN cord-001273-plz1ja2e 189 31 the the DT cord-001273-plz1ja2e 189 32 small small JJ cord-001273-plz1ja2e 189 33 intestine intestine NN cord-001273-plz1ja2e 189 34 ( ( -LRB- cord-001273-plz1ja2e 189 35 Okamoto Okamoto NNP cord-001273-plz1ja2e 189 36 , , , cord-001273-plz1ja2e 189 37 1994 1994 CD cord-001273-plz1ja2e 189 38 ) ) -RRB- cord-001273-plz1ja2e 189 39 . . . cord-001273-plz1ja2e 190 1 More more RBR cord-001273-plz1ja2e 190 2 recently recently RB cord-001273-plz1ja2e 190 3 , , , cord-001273-plz1ja2e 190 4 human human JJ cord-001273-plz1ja2e 190 5 E e NN cord-001273-plz1ja2e 190 6 - - NN cord-001273-plz1ja2e 190 7 cadherin cadherin NN cord-001273-plz1ja2e 190 8 ( ( -LRB- cord-001273-plz1ja2e 190 9 hEcad hEcad NNP cord-001273-plz1ja2e 190 10 ) ) -RRB- cord-001273-plz1ja2e 190 11 expressing express VBG cord-001273-plz1ja2e 190 12 mice mouse NNS cord-001273-plz1ja2e 190 13 , , , cord-001273-plz1ja2e 190 14 a a DT cord-001273-plz1ja2e 190 15 mouse mouse NN cord-001273-plz1ja2e 190 16 line line NN cord-001273-plz1ja2e 190 17 permissive permissive JJ cord-001273-plz1ja2e 190 18 for for IN cord-001273-plz1ja2e 190 19 Listeria Listeria NNP cord-001273-plz1ja2e 190 20 oral oral JJ cord-001273-plz1ja2e 190 21 infection infection NN cord-001273-plz1ja2e 191 1 ( ( -LRB- cord-001273-plz1ja2e 191 2 Lecuit Lecuit NNP cord-001273-plz1ja2e 191 3 et et NNP cord-001273-plz1ja2e 191 4 al al NNP cord-001273-plz1ja2e 191 5 . . NNP cord-001273-plz1ja2e 191 6 , , , cord-001273-plz1ja2e 191 7 2001 2001 CD cord-001273-plz1ja2e 191 8 ) ) -RRB- cord-001273-plz1ja2e 191 9 , , , cord-001273-plz1ja2e 191 10 were be VBD cord-001273-plz1ja2e 191 11 used use VBN cord-001273-plz1ja2e 191 12 to to TO cord-001273-plz1ja2e 191 13 study study VB cord-001273-plz1ja2e 191 14 cells cell NNS cord-001273-plz1ja2e 191 15 involved involve VBN cord-001273-plz1ja2e 191 16 in in IN cord-001273-plz1ja2e 191 17 intestinal intestinal JJ cord-001273-plz1ja2e 191 18 mucosal mucosal JJ cord-001273-plz1ja2e 191 19 immunity immunity NN cord-001273-plz1ja2e 191 20 . . . cord-001273-plz1ja2e 192 1 Infection infection NN cord-001273-plz1ja2e 192 2 induced induce VBD cord-001273-plz1ja2e 192 3 IFN IFN NNP cord-001273-plz1ja2e 192 4 - - HYPH cord-001273-plz1ja2e 192 5 γ γ NN cord-001273-plz1ja2e 192 6 production production NN cord-001273-plz1ja2e 192 7 in in IN cord-001273-plz1ja2e 192 8 NK NK NNP cord-001273-plz1ja2e 192 9 cells cell NNS cord-001273-plz1ja2e 192 10 of of IN cord-001273-plz1ja2e 192 11 the the DT cord-001273-plz1ja2e 192 12 small small JJ cord-001273-plz1ja2e 192 13 intestine intestine NN cord-001273-plz1ja2e 193 1 ( ( -LRB- cord-001273-plz1ja2e 193 2 Reynders Reynders NNP cord-001273-plz1ja2e 193 3 et et NNP cord-001273-plz1ja2e 193 4 al al NNP cord-001273-plz1ja2e 193 5 . . NNP cord-001273-plz1ja2e 193 6 , , , cord-001273-plz1ja2e 193 7 2011 2011 CD cord-001273-plz1ja2e 193 8 ) ) -RRB- cord-001273-plz1ja2e 193 9 . . . cord-001273-plz1ja2e 194 1 The the DT cord-001273-plz1ja2e 194 2 production production NN cord-001273-plz1ja2e 194 3 of of IN cord-001273-plz1ja2e 194 4 IFN IFN NNP cord-001273-plz1ja2e 194 5 - - HYPH cord-001273-plz1ja2e 194 6 γ γ NNP cord-001273-plz1ja2e 194 7 by by IN cord-001273-plz1ja2e 194 8 immune immune JJ cord-001273-plz1ja2e 194 9 cells cell NNS cord-001273-plz1ja2e 194 10 promotes promote VBZ cord-001273-plz1ja2e 194 11 bacterial bacterial JJ cord-001273-plz1ja2e 194 12 clearance clearance NN cord-001273-plz1ja2e 194 13 and and CC cord-001273-plz1ja2e 194 14 is be VBZ cord-001273-plz1ja2e 194 15 thus thus RB cord-001273-plz1ja2e 194 16 critical critical JJ cord-001273-plz1ja2e 194 17 in in IN cord-001273-plz1ja2e 194 18 controlling control VBG cord-001273-plz1ja2e 194 19 primary primary JJ cord-001273-plz1ja2e 194 20 L. L. NNP cord-001273-plz1ja2e 194 21 monocytogenes monocytogenes NN cord-001273-plz1ja2e 194 22 infections infection NNS cord-001273-plz1ja2e 194 23 ( ( -LRB- cord-001273-plz1ja2e 194 24 Zenewicz Zenewicz NNP cord-001273-plz1ja2e 194 25 and and CC cord-001273-plz1ja2e 194 26 Shen Shen NNP cord-001273-plz1ja2e 194 27 , , , cord-001273-plz1ja2e 194 28 2007 2007 CD cord-001273-plz1ja2e 194 29 ) ) -RRB- cord-001273-plz1ja2e 194 30 . . . cord-001273-plz1ja2e 195 1 Injection injection NN cord-001273-plz1ja2e 195 2 of of IN cord-001273-plz1ja2e 195 3 neutralizing neutralize VBG cord-001273-plz1ja2e 195 4 monoclonal monoclonal JJ cord-001273-plz1ja2e 195 5 anti anti JJ cord-001273-plz1ja2e 195 6 - - JJ cord-001273-plz1ja2e 195 7 IFN IFN NNP cord-001273-plz1ja2e 195 8 - - HYPH cord-001273-plz1ja2e 195 9 γ γ NN cord-001273-plz1ja2e 195 10 antibodies antibody NNS cord-001273-plz1ja2e 195 11 in in IN cord-001273-plz1ja2e 195 12 mice mouse NNS cord-001273-plz1ja2e 195 13 infected infect VBN cord-001273-plz1ja2e 195 14 intraperitoneally intraperitoneally RB cord-001273-plz1ja2e 195 15 with with IN cord-001273-plz1ja2e 195 16 L. L. NNP cord-001273-plz1ja2e 195 17 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 195 18 inhibits inhibit VBZ cord-001273-plz1ja2e 195 19 macrophage macrophage NN cord-001273-plz1ja2e 195 20 activation activation NN cord-001273-plz1ja2e 195 21 and and CC cord-001273-plz1ja2e 195 22 increases increase VBZ cord-001273-plz1ja2e 195 23 the the DT cord-001273-plz1ja2e 195 24 mortality mortality NN cord-001273-plz1ja2e 195 25 rate rate NN cord-001273-plz1ja2e 195 26 ( ( -LRB- cord-001273-plz1ja2e 195 27 Buchmeier Buchmeier NNP cord-001273-plz1ja2e 195 28 and and CC cord-001273-plz1ja2e 195 29 Schreiber Schreiber NNP cord-001273-plz1ja2e 195 30 , , , cord-001273-plz1ja2e 195 31 1985 1985 CD cord-001273-plz1ja2e 195 32 ) ) -RRB- cord-001273-plz1ja2e 195 33 . . . cord-001273-plz1ja2e 196 1 In in IN cord-001273-plz1ja2e 196 2 addition addition NN cord-001273-plz1ja2e 196 3 , , , cord-001273-plz1ja2e 196 4 resistance resistance NN cord-001273-plz1ja2e 196 5 of of IN cord-001273-plz1ja2e 196 6 IFN IFN NNP cord-001273-plz1ja2e 196 7 - - HYPH cord-001273-plz1ja2e 196 8 γ γ NNP cord-001273-plz1ja2e 196 9 gene gene NN cord-001273-plz1ja2e 196 10 or or CC cord-001273-plz1ja2e 196 11 IFN IFN NNP cord-001273-plz1ja2e 196 12 - - HYPH cord-001273-plz1ja2e 196 13 γ γ NN cord-001273-plz1ja2e 196 14 receptor receptor NN cord-001273-plz1ja2e 196 15 knock knock VB cord-001273-plz1ja2e 196 16 - - HYPH cord-001273-plz1ja2e 196 17 out out RP cord-001273-plz1ja2e 196 18 mice mouse NNS cord-001273-plz1ja2e 196 19 infected infect VBN cord-001273-plz1ja2e 196 20 intravenously intravenously RB cord-001273-plz1ja2e 196 21 with with IN cord-001273-plz1ja2e 196 22 L. L. NNP cord-001273-plz1ja2e 196 23 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 196 24 is be VBZ cord-001273-plz1ja2e 196 25 Frontiers Frontiers NNPS cord-001273-plz1ja2e 196 26 in in IN cord-001273-plz1ja2e 196 27 Cellular Cellular NNP cord-001273-plz1ja2e 196 28 and and CC cord-001273-plz1ja2e 196 29 Infection Infection NNP cord-001273-plz1ja2e 196 30 Microbiology Microbiology NNP cord-001273-plz1ja2e 196 31 www.frontiersin.org www.frontiersin.org IN cord-001273-plz1ja2e 196 32 April April NNP cord-001273-plz1ja2e 196 33 2014 2014 CD cord-001273-plz1ja2e 197 1 | | NNP cord-001273-plz1ja2e 198 1 Volume volume NN cord-001273-plz1ja2e 198 2 4 4 CD cord-001273-plz1ja2e 198 3 | | NNP cord-001273-plz1ja2e 198 4 Article Article NNP cord-001273-plz1ja2e 198 5 50 50 CD cord-001273-plz1ja2e 198 6 | | SYM cord-001273-plz1ja2e 198 7 6 6 CD cord-001273-plz1ja2e 198 8 severely severely RB cord-001273-plz1ja2e 198 9 impaired impair VBD cord-001273-plz1ja2e 198 10 Harty Harty NNP cord-001273-plz1ja2e 198 11 and and CC cord-001273-plz1ja2e 198 12 Bevan Bevan NNP cord-001273-plz1ja2e 198 13 , , , cord-001273-plz1ja2e 198 14 1995 1995 CD cord-001273-plz1ja2e 198 15 ) ) -RRB- cord-001273-plz1ja2e 198 16 . . . cord-001273-plz1ja2e 199 1 Recent recent JJ cord-001273-plz1ja2e 199 2 work work NN cord-001273-plz1ja2e 199 3 using use VBG cord-001273-plz1ja2e 199 4 cell cell NN cord-001273-plz1ja2e 199 5 - - HYPH cord-001273-plz1ja2e 199 6 type type NN cord-001273-plz1ja2e 199 7 specific specific JJ cord-001273-plz1ja2e 199 8 inactivation inactivation NN cord-001273-plz1ja2e 199 9 of of IN cord-001273-plz1ja2e 199 10 STAT1 stat1 NN cord-001273-plz1ja2e 199 11 in in IN cord-001273-plz1ja2e 199 12 mice mouse NNS cord-001273-plz1ja2e 199 13 elegantly elegantly RB cord-001273-plz1ja2e 199 14 demonstrated demonstrate VBD cord-001273-plz1ja2e 199 15 the the DT cord-001273-plz1ja2e 199 16 key key JJ cord-001273-plz1ja2e 199 17 role role NN cord-001273-plz1ja2e 199 18 of of IN cord-001273-plz1ja2e 199 19 IFN IFN NNP cord-001273-plz1ja2e 199 20 - - HYPH cord-001273-plz1ja2e 199 21 γ γ NNP cord-001273-plz1ja2e 199 22 and and CC cord-001273-plz1ja2e 199 23 STAT1 stat1 XX cord-001273-plz1ja2e 199 24 in in IN cord-001273-plz1ja2e 199 25 macrophage macrophage NN cord-001273-plz1ja2e 199 26 activation activation NN cord-001273-plz1ja2e 199 27 and and CC cord-001273-plz1ja2e 199 28 clearance clearance NN cord-001273-plz1ja2e 199 29 of of IN cord-001273-plz1ja2e 199 30 Listeria Listeria NNP cord-001273-plz1ja2e 199 31 ( ( -LRB- cord-001273-plz1ja2e 199 32 Kernbauer Kernbauer NNP cord-001273-plz1ja2e 199 33 et et NNP cord-001273-plz1ja2e 199 34 al al NNP cord-001273-plz1ja2e 199 35 . . NNP cord-001273-plz1ja2e 199 36 , , , cord-001273-plz1ja2e 199 37 2012 2012 CD cord-001273-plz1ja2e 199 38 ) ) -RRB- cord-001273-plz1ja2e 199 39 . . . cord-001273-plz1ja2e 200 1 Interestingly interestingly RB cord-001273-plz1ja2e 200 2 , , , cord-001273-plz1ja2e 200 3 the the DT cord-001273-plz1ja2e 200 4 role role NN cord-001273-plz1ja2e 200 5 of of IN cord-001273-plz1ja2e 200 6 STAT1 stat1 NN cord-001273-plz1ja2e 200 7 was be VBD cord-001273-plz1ja2e 200 8 extremely extremely RB cord-001273-plz1ja2e 200 9 different different JJ cord-001273-plz1ja2e 200 10 after after IN cord-001273-plz1ja2e 200 11 infection infection NN cord-001273-plz1ja2e 200 12 of of IN cord-001273-plz1ja2e 200 13 immunized immunize VBN cord-001273-plz1ja2e 200 14 mice mouse NNS cord-001273-plz1ja2e 200 15 . . . cord-001273-plz1ja2e 201 1 STAT1 stat1 XX cord-001273-plz1ja2e 202 1 signaling signal VBG cord-001273-plz1ja2e 202 2 in in IN cord-001273-plz1ja2e 202 3 T T NNP cord-001273-plz1ja2e 202 4 cells cell NNS cord-001273-plz1ja2e 202 5 and and CC cord-001273-plz1ja2e 202 6 dendritic dendritic JJ cord-001273-plz1ja2e 202 7 cells cell NNS cord-001273-plz1ja2e 202 8 was be VBD cord-001273-plz1ja2e 202 9 critical critical JJ cord-001273-plz1ja2e 202 10 for for IN cord-001273-plz1ja2e 202 11 adaptive adaptive JJ cord-001273-plz1ja2e 202 12 immunity immunity NN cord-001273-plz1ja2e 202 13 to to IN cord-001273-plz1ja2e 202 14 Listeria Listeria NNP cord-001273-plz1ja2e 202 15 , , , cord-001273-plz1ja2e 202 16 while while IN cord-001273-plz1ja2e 202 17 IFN IFN NNP cord-001273-plz1ja2e 202 18 - - HYPH cord-001273-plz1ja2e 202 19 γ γ NNP cord-001273-plz1ja2e 202 20 - - HYPH cord-001273-plz1ja2e 202 21 activated activate VBN cord-001273-plz1ja2e 202 22 macrophages macrophage NNS cord-001273-plz1ja2e 202 23 were be VBD cord-001273-plz1ja2e 202 24 not not RB cord-001273-plz1ja2e 202 25 essential essential JJ cord-001273-plz1ja2e 202 26 anymore anymore RB cord-001273-plz1ja2e 202 27 once once IN cord-001273-plz1ja2e 202 28 memory memory NN cord-001273-plz1ja2e 202 29 cells cell NNS cord-001273-plz1ja2e 202 30 were be VBD cord-001273-plz1ja2e 202 31 produced produce VBN cord-001273-plz1ja2e 202 32 . . . cord-001273-plz1ja2e 203 1 Upon upon IN cord-001273-plz1ja2e 203 2 oral oral JJ cord-001273-plz1ja2e 203 3 infection infection NN cord-001273-plz1ja2e 203 4 of of IN cord-001273-plz1ja2e 203 5 hEcad hEcad NNP cord-001273-plz1ja2e 203 6 mice mouse NNS cord-001273-plz1ja2e 203 7 with with IN cord-001273-plz1ja2e 203 8 Listeria Listeria NNP cord-001273-plz1ja2e 203 9 , , , cord-001273-plz1ja2e 203 10 IFN IFN NNP cord-001273-plz1ja2e 203 11 - - HYPH cord-001273-plz1ja2e 203 12 γ γ NNP cord-001273-plz1ja2e 203 13 contributes contribute VBZ cord-001273-plz1ja2e 203 14 to to IN cord-001273-plz1ja2e 203 15 the the DT cord-001273-plz1ja2e 203 16 control control NN cord-001273-plz1ja2e 203 17 of of IN cord-001273-plz1ja2e 203 18 bacterial bacterial JJ cord-001273-plz1ja2e 203 19 burden burden NN cord-001273-plz1ja2e 203 20 in in IN cord-001273-plz1ja2e 203 21 the the DT cord-001273-plz1ja2e 203 22 intestine intestine NN cord-001273-plz1ja2e 203 23 and and CC cord-001273-plz1ja2e 203 24 of of IN cord-001273-plz1ja2e 203 25 bacterial bacterial JJ cord-001273-plz1ja2e 203 26 dissemination dissemination NN cord-001273-plz1ja2e 203 27 to to IN cord-001273-plz1ja2e 203 28 other other JJ cord-001273-plz1ja2e 203 29 organs organ NNS cord-001273-plz1ja2e 203 30 . . . cord-001273-plz1ja2e 204 1 For for IN cord-001273-plz1ja2e 204 2 instance instance NN cord-001273-plz1ja2e 204 3 , , , cord-001273-plz1ja2e 204 4 blocking block VBG cord-001273-plz1ja2e 204 5 IFN IFN NNP cord-001273-plz1ja2e 204 6 - - HYPH cord-001273-plz1ja2e 204 7 γ γ NNP cord-001273-plz1ja2e 204 8 with with IN cord-001273-plz1ja2e 204 9 neutralizing neutralize VBG cord-001273-plz1ja2e 204 10 antibodies antibody NNS cord-001273-plz1ja2e 204 11 increases increase VBZ cord-001273-plz1ja2e 204 12 Listeria Listeria NNP cord-001273-plz1ja2e 204 13 load load NN cord-001273-plz1ja2e 204 14 in in IN cord-001273-plz1ja2e 204 15 the the DT cord-001273-plz1ja2e 204 16 small small JJ cord-001273-plz1ja2e 204 17 intestine intestine NN cord-001273-plz1ja2e 204 18 , , , cord-001273-plz1ja2e 204 19 the the DT cord-001273-plz1ja2e 204 20 mesenteric mesenteric JJ cord-001273-plz1ja2e 204 21 lymph lymph NN cord-001273-plz1ja2e 204 22 nodes node NNS cord-001273-plz1ja2e 204 23 and and CC cord-001273-plz1ja2e 204 24 in in IN cord-001273-plz1ja2e 204 25 the the DT cord-001273-plz1ja2e 204 26 spleen spleen NN cord-001273-plz1ja2e 204 27 of of IN cord-001273-plz1ja2e 204 28 mice mouse NNS cord-001273-plz1ja2e 204 29 infected infect VBN cord-001273-plz1ja2e 204 30 orally orally RB cord-001273-plz1ja2e 205 1 ( ( -LRB- cord-001273-plz1ja2e 205 2 Reynders Reynders NNP cord-001273-plz1ja2e 205 3 et et NNP cord-001273-plz1ja2e 205 4 al al NNP cord-001273-plz1ja2e 205 5 . . NNP cord-001273-plz1ja2e 205 6 , , , cord-001273-plz1ja2e 205 7 2011 2011 CD cord-001273-plz1ja2e 205 8 ) ) -RRB- cord-001273-plz1ja2e 205 9 . . . cord-001273-plz1ja2e 206 1 In in IN cord-001273-plz1ja2e 206 2 contrast contrast NN cord-001273-plz1ja2e 206 3 to to IN cord-001273-plz1ja2e 206 4 IFN IFN NNP cord-001273-plz1ja2e 206 5 - - HYPH cord-001273-plz1ja2e 206 6 γ γ NNP cord-001273-plz1ja2e 206 7 , , , cord-001273-plz1ja2e 206 8 type type NN cord-001273-plz1ja2e 206 9 I I NNP cord-001273-plz1ja2e 206 10 - - HYPH cord-001273-plz1ja2e 206 11 IFN IFN NNP cord-001273-plz1ja2e 206 12 is be VBZ cord-001273-plz1ja2e 206 13 beneficial beneficial JJ cord-001273-plz1ja2e 206 14 to to IN cord-001273-plz1ja2e 206 15 L. L. NNP cord-001273-plz1ja2e 206 16 monocytogenes monocytogene NNS cord-001273-plz1ja2e 206 17 . . . cord-001273-plz1ja2e 207 1 Mice mouse NNS cord-001273-plz1ja2e 207 2 lacking lack VBG cord-001273-plz1ja2e 207 3 type type NN cord-001273-plz1ja2e 207 4 I I NNP cord-001273-plz1ja2e 207 5 - - HYPH cord-001273-plz1ja2e 207 6 IFN IFN NNP cord-001273-plz1ja2e 207 7 receptor receptor NN cord-001273-plz1ja2e 207 8 or or CC cord-001273-plz1ja2e 207 9 IRF3 IRF3 NNP cord-001273-plz1ja2e 207 10 are be VBP cord-001273-plz1ja2e 207 11 more more RBR cord-001273-plz1ja2e 207 12 resistant resistant JJ cord-001273-plz1ja2e 207 13 to to IN cord-001273-plz1ja2e 207 14 Listeria Listeria NNP cord-001273-plz1ja2e 207 15 intraperitoneal intraperitoneal JJ cord-001273-plz1ja2e 207 16 or or CC cord-001273-plz1ja2e 207 17 intravenous intravenous JJ cord-001273-plz1ja2e 207 18 infection infection NN cord-001273-plz1ja2e 208 1 ( ( -LRB- cord-001273-plz1ja2e 208 2 Auerbuch Auerbuch NNP cord-001273-plz1ja2e 208 3 et et NNP cord-001273-plz1ja2e 208 4 al al NNP cord-001273-plz1ja2e 208 5 . . NNP cord-001273-plz1ja2e 208 6 , , , cord-001273-plz1ja2e 208 7 2004 2004 CD cord-001273-plz1ja2e 209 1 ; ; : cord-001273-plz1ja2e 209 2 Carrero Carrero NNP cord-001273-plz1ja2e 209 3 et et NNP cord-001273-plz1ja2e 209 4 al al NNP cord-001273-plz1ja2e 209 5 . . NNP cord-001273-plz1ja2e 209 6 , , , cord-001273-plz1ja2e 209 7 2004 2004 CD cord-001273-plz1ja2e 209 8 ; ; : cord-001273-plz1ja2e 209 9 O'Connell O'Connell NNP cord-001273-plz1ja2e 209 10 et et NNP cord-001273-plz1ja2e 209 11 al al NNP cord-001273-plz1ja2e 209 12 . . NNP cord-001273-plz1ja2e 209 13 , , , cord-001273-plz1ja2e 209 14 2004 2004 CD cord-001273-plz1ja2e 210 1 ; ; : cord-001273-plz1ja2e 210 2 Garifulin Garifulin NNP cord-001273-plz1ja2e 210 3 et et NNP cord-001273-plz1ja2e 210 4 al al NNP cord-001273-plz1ja2e 210 5 . . NNP cord-001273-plz1ja2e 210 6 , , , cord-001273-plz1ja2e 210 7 2007 2007 CD cord-001273-plz1ja2e 210 8 ; ; : cord-001273-plz1ja2e 210 9 Jia Jia NNP cord-001273-plz1ja2e 210 10 et et NNP cord-001273-plz1ja2e 210 11 al al NNP cord-001273-plz1ja2e 210 12 . . NNP cord-001273-plz1ja2e 210 13 , , , cord-001273-plz1ja2e 210 14 2009 2009 CD cord-001273-plz1ja2e 210 15 ) ) -RRB- cord-001273-plz1ja2e 210 16 . . . cord-001273-plz1ja2e 211 1 The the DT cord-001273-plz1ja2e 211 2 role role NN cord-001273-plz1ja2e 211 3 of of IN cord-001273-plz1ja2e 211 4 type type NN cord-001273-plz1ja2e 211 5 I i NN cord-001273-plz1ja2e 211 6 - - HYPH cord-001273-plz1ja2e 211 7 IFNs ifn NNS cord-001273-plz1ja2e 211 8 in in IN cord-001273-plz1ja2e 211 9 increasing increase VBG cord-001273-plz1ja2e 211 10 host host NN cord-001273-plz1ja2e 211 11 susceptibility susceptibility NN cord-001273-plz1ja2e 211 12 could could MD cord-001273-plz1ja2e 211 13 be be VB cord-001273-plz1ja2e 211 14 explained explain VBN cord-001273-plz1ja2e 211 15 by by IN cord-001273-plz1ja2e 211 16 modulation modulation NN cord-001273-plz1ja2e 211 17 of of IN cord-001273-plz1ja2e 211 18 components component NNS cord-001273-plz1ja2e 211 19 of of IN cord-001273-plz1ja2e 211 20 the the DT cord-001273-plz1ja2e 211 21 immune immune JJ cord-001273-plz1ja2e 211 22 response response NN cord-001273-plz1ja2e 211 23 involved involve VBN cord-001273-plz1ja2e 211 24 in in IN cord-001273-plz1ja2e 211 25 controlling control VBG cord-001273-plz1ja2e 211 26 bacterial bacterial JJ cord-001273-plz1ja2e 211 27 growth growth NN cord-001273-plz1ja2e 211 28 such such JJ cord-001273-plz1ja2e 211 29 as as IN cord-001273-plz1ja2e 211 30 induction induction NN cord-001273-plz1ja2e 211 31 of of IN cord-001273-plz1ja2e 211 32 T T NNP cord-001273-plz1ja2e 211 33 cell cell NN cord-001273-plz1ja2e 211 34 apoptosis apoptosis NN cord-001273-plz1ja2e 211 35 , , , cord-001273-plz1ja2e 211 36 resulting result VBG cord-001273-plz1ja2e 211 37 in in IN cord-001273-plz1ja2e 211 38 greater great JJR cord-001273-plz1ja2e 211 39 IL-10 IL-10 NNP cord-001273-plz1ja2e 211 40 secretion secretion NN cord-001273-plz1ja2e 211 41 by by IN cord-001273-plz1ja2e 211 42 phagocytic phagocytic JJ cord-001273-plz1ja2e 211 43 cells cell NNS cord-001273-plz1ja2e 211 44 , , , cord-001273-plz1ja2e 211 45 in in IN cord-001273-plz1ja2e 211 46 turn turn NN cord-001273-plz1ja2e 211 47 dampening dampen VBG cord-001273-plz1ja2e 211 48 the the DT cord-001273-plz1ja2e 211 49 innate innate JJ cord-001273-plz1ja2e 211 50 immune immune JJ cord-001273-plz1ja2e 211 51 response response NN cord-001273-plz1ja2e 211 52 ( ( -LRB- cord-001273-plz1ja2e 211 53 Carrero Carrero NNP cord-001273-plz1ja2e 211 54 and and CC cord-001273-plz1ja2e 211 55 Unanue Unanue NNP cord-001273-plz1ja2e 211 56 , , , cord-001273-plz1ja2e 211 57 2006 2006 CD cord-001273-plz1ja2e 211 58 ) ) -RRB- cord-001273-plz1ja2e 211 59 , , , cord-001273-plz1ja2e 211 60 the the DT cord-001273-plz1ja2e 211 61 downregulation downregulation NN cord-001273-plz1ja2e 211 62 of of IN cord-001273-plz1ja2e 211 63 IFN IFN NNP cord-001273-plz1ja2e 211 64 - - HYPH cord-001273-plz1ja2e 211 65 γR γR NNP cord-001273-plz1ja2e 212 1 ( ( -LRB- cord-001273-plz1ja2e 212 2 Rayamajhi Rayamajhi NNP cord-001273-plz1ja2e 212 3 et et NNP cord-001273-plz1ja2e 212 4 al al NNP cord-001273-plz1ja2e 212 5 . . NNP cord-001273-plz1ja2e 212 6 , , , cord-001273-plz1ja2e 212 7 2010 2010 CD cord-001273-plz1ja2e 212 8 ; ; : cord-001273-plz1ja2e 212 9 Kearney Kearney NNP cord-001273-plz1ja2e 212 10 et et NNP cord-001273-plz1ja2e 212 11 al al NNP cord-001273-plz1ja2e 212 12 . . NNP cord-001273-plz1ja2e 212 13 , , , cord-001273-plz1ja2e 212 14 2013 2013 CD cord-001273-plz1ja2e 212 15 ) ) -RRB- cord-001273-plz1ja2e 212 16 , , , cord-001273-plz1ja2e 212 17 or or CC cord-001273-plz1ja2e 212 18 neutrophil neutrophil NN cord-001273-plz1ja2e 212 19 recruitment recruitment NN cord-001273-plz1ja2e 212 20 ( ( -LRB- cord-001273-plz1ja2e 212 21 Brzoza Brzoza NNP cord-001273-plz1ja2e 212 22 - - HYPH cord-001273-plz1ja2e 212 23 Lewis Lewis NNP cord-001273-plz1ja2e 212 24 et et NNP cord-001273-plz1ja2e 212 25 al al NNP cord-001273-plz1ja2e 212 26 . . NNP cord-001273-plz1ja2e 212 27 , , , cord-001273-plz1ja2e 212 28 2012 2012 CD cord-001273-plz1ja2e 212 29 ) ) -RRB- cord-001273-plz1ja2e 212 30 . . . cord-001273-plz1ja2e 213 1 As as IN cord-001273-plz1ja2e 213 2 shown show VBN cord-001273-plz1ja2e 213 3 recently recently RB cord-001273-plz1ja2e 213 4 , , , cord-001273-plz1ja2e 213 5 STING sting NN cord-001273-plz1ja2e 213 6 - - HYPH cord-001273-plz1ja2e 213 7 dependent dependent JJ cord-001273-plz1ja2e 213 8 activation activation NN cord-001273-plz1ja2e 213 9 of of IN cord-001273-plz1ja2e 213 10 type type NN cord-001273-plz1ja2e 213 11 I I NNP cord-001273-plz1ja2e 213 12 - - HYPH cord-001273-plz1ja2e 213 13 IFN IFN NNP cord-001273-plz1ja2e 213 14 reduces reduce VBZ cord-001273-plz1ja2e 213 15 the the DT cord-001273-plz1ja2e 213 16 adaptive adaptive JJ cord-001273-plz1ja2e 213 17 immune immune JJ cord-001273-plz1ja2e 213 18 response response NN cord-001273-plz1ja2e 213 19 to to IN cord-001273-plz1ja2e 213 20 L. L. NNP cord-001273-plz1ja2e 213 21 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 213 22 ( ( -LRB- cord-001273-plz1ja2e 213 23 Archer Archer NNP cord-001273-plz1ja2e 213 24 et et NNP cord-001273-plz1ja2e 213 25 al al NNP cord-001273-plz1ja2e 213 26 . . NNP cord-001273-plz1ja2e 213 27 , , , cord-001273-plz1ja2e 213 28 2014 2014 CD cord-001273-plz1ja2e 213 29 ) ) -RRB- cord-001273-plz1ja2e 213 30 . . . cord-001273-plz1ja2e 214 1 In in IN cord-001273-plz1ja2e 214 2 contrast contrast NN cord-001273-plz1ja2e 214 3 , , , cord-001273-plz1ja2e 214 4 recent recent JJ cord-001273-plz1ja2e 214 5 studies study NNS cord-001273-plz1ja2e 214 6 showed show VBD cord-001273-plz1ja2e 214 7 that that IN cord-001273-plz1ja2e 214 8 type type NN cord-001273-plz1ja2e 214 9 I i NN cord-001273-plz1ja2e 214 10 - - HYPH cord-001273-plz1ja2e 214 11 IFNs IFNs NNP cord-001273-plz1ja2e 214 12 can can MD cord-001273-plz1ja2e 214 13 also also RB cord-001273-plz1ja2e 214 14 play play VB cord-001273-plz1ja2e 214 15 a a DT cord-001273-plz1ja2e 214 16 beneficial beneficial JJ cord-001273-plz1ja2e 214 17 role role NN cord-001273-plz1ja2e 214 18 for for IN cord-001273-plz1ja2e 214 19 the the DT cord-001273-plz1ja2e 214 20 host host NN cord-001273-plz1ja2e 214 21 during during IN cord-001273-plz1ja2e 214 22 Listeria Listeria NNP cord-001273-plz1ja2e 214 23 infection infection NN cord-001273-plz1ja2e 214 24 , , , cord-001273-plz1ja2e 214 25 pointing point VBG cord-001273-plz1ja2e 214 26 to to IN cord-001273-plz1ja2e 214 27 the the DT cord-001273-plz1ja2e 214 28 infection infection NN cord-001273-plz1ja2e 214 29 route route NN cord-001273-plz1ja2e 214 30 and and CC cord-001273-plz1ja2e 214 31 the the DT cord-001273-plz1ja2e 214 32 timing timing NN cord-001273-plz1ja2e 214 33 of of IN cord-001273-plz1ja2e 214 34 type type NN cord-001273-plz1ja2e 214 35 I I NNP cord-001273-plz1ja2e 214 36 - - HYPH cord-001273-plz1ja2e 214 37 IFN IFN NNP cord-001273-plz1ja2e 214 38 production production NN cord-001273-plz1ja2e 214 39 as as IN cord-001273-plz1ja2e 214 40 determinative determinative JJ cord-001273-plz1ja2e 214 41 factors factor NNS cord-001273-plz1ja2e 214 42 ( ( -LRB- cord-001273-plz1ja2e 214 43 Pontiroli Pontiroli NNP cord-001273-plz1ja2e 214 44 et et NNP cord-001273-plz1ja2e 214 45 al al NNP cord-001273-plz1ja2e 214 46 . . NNP cord-001273-plz1ja2e 214 47 , , , cord-001273-plz1ja2e 214 48 2012 2012 CD cord-001273-plz1ja2e 214 49 ; ; : cord-001273-plz1ja2e 214 50 Kernbauer Kernbauer NNP cord-001273-plz1ja2e 214 51 et et NNP cord-001273-plz1ja2e 214 52 al al NNP cord-001273-plz1ja2e 214 53 . . NNP cord-001273-plz1ja2e 214 54 , , , cord-001273-plz1ja2e 214 55 2013 2013 CD cord-001273-plz1ja2e 214 56 ) ) -RRB- cord-001273-plz1ja2e 214 57 . . . cord-001273-plz1ja2e 215 1 Interestingly interestingly RB cord-001273-plz1ja2e 215 2 , , , cord-001273-plz1ja2e 215 3 different different JJ cord-001273-plz1ja2e 215 4 strains strain NNS cord-001273-plz1ja2e 215 5 of of IN cord-001273-plz1ja2e 215 6 L. L. NNP cord-001273-plz1ja2e 215 7 monocytogenes monocytogene NNS cord-001273-plz1ja2e 215 8 have have VBP cord-001273-plz1ja2e 215 9 been be VBN cord-001273-plz1ja2e 215 10 shown show VBN cord-001273-plz1ja2e 215 11 to to TO cord-001273-plz1ja2e 215 12 vary vary VB cord-001273-plz1ja2e 215 13 greatly greatly RB cord-001273-plz1ja2e 215 14 in in IN cord-001273-plz1ja2e 215 15 their -PRON- PRP$ cord-001273-plz1ja2e 215 16 capacity capacity NN cord-001273-plz1ja2e 215 17 to to TO cord-001273-plz1ja2e 215 18 induce induce VB cord-001273-plz1ja2e 215 19 IFN IFN NNP cord-001273-plz1ja2e 215 20 - - HYPH cord-001273-plz1ja2e 215 21 β β NNP cord-001273-plz1ja2e 215 22 ( ( -LRB- cord-001273-plz1ja2e 215 23 Reutterer Reutterer NNP cord-001273-plz1ja2e 215 24 et et NNP cord-001273-plz1ja2e 215 25 al al NNP cord-001273-plz1ja2e 215 26 . . NNP cord-001273-plz1ja2e 215 27 , , , cord-001273-plz1ja2e 215 28 2008 2008 CD cord-001273-plz1ja2e 215 29 ; ; : cord-001273-plz1ja2e 215 30 Schwartz Schwartz NNP cord-001273-plz1ja2e 215 31 et et NNP cord-001273-plz1ja2e 215 32 al al NNP cord-001273-plz1ja2e 215 33 . . NNP cord-001273-plz1ja2e 215 34 , , , cord-001273-plz1ja2e 215 35 2012 2012 CD cord-001273-plz1ja2e 215 36 ) ) -RRB- cord-001273-plz1ja2e 215 37 . . . cord-001273-plz1ja2e 216 1 The the DT cord-001273-plz1ja2e 216 2 LO28 LO28 NNP cord-001273-plz1ja2e 216 3 strain strain NN cord-001273-plz1ja2e 216 4 hyperinduces hyperinduce NNS cord-001273-plz1ja2e 216 5 IFN IFN NNP cord-001273-plz1ja2e 216 6 - - HYPH cord-001273-plz1ja2e 216 7 β β NNP cord-001273-plz1ja2e 216 8 ( ( -LRB- cord-001273-plz1ja2e 216 9 Reutterer Reutterer NNP cord-001273-plz1ja2e 216 10 et et NNP cord-001273-plz1ja2e 216 11 al al NNP cord-001273-plz1ja2e 216 12 . . NNP cord-001273-plz1ja2e 216 13 , , , cord-001273-plz1ja2e 216 14 2008 2008 CD cord-001273-plz1ja2e 216 15 ) ) -RRB- cord-001273-plz1ja2e 216 16 . . . cord-001273-plz1ja2e 217 1 This this DT cord-001273-plz1ja2e 217 2 strain strain NN cord-001273-plz1ja2e 217 3 bears bear VBZ cord-001273-plz1ja2e 217 4 a a DT cord-001273-plz1ja2e 217 5 nonfunctional nonfunctional JJ cord-001273-plz1ja2e 217 6 BrtA BrtA NNP cord-001273-plz1ja2e 217 7 ( ( -LRB- cord-001273-plz1ja2e 217 8 also also RB cord-001273-plz1ja2e 217 9 named name VBN cord-001273-plz1ja2e 217 10 TetR TetR NNP cord-001273-plz1ja2e 217 11 ) ) -RRB- cord-001273-plz1ja2e 217 12 , , , cord-001273-plz1ja2e 217 13 the the DT cord-001273-plz1ja2e 217 14 transcriptional transcriptional JJ cord-001273-plz1ja2e 217 15 repressor repressor NN cord-001273-plz1ja2e 217 16 of of IN cord-001273-plz1ja2e 217 17 the the DT cord-001273-plz1ja2e 217 18 multidrug multidrug NN cord-001273-plz1ja2e 217 19 efflux efflux NN cord-001273-plz1ja2e 217 20 pump pump NN cord-001273-plz1ja2e 218 1 MdrT MdrT NNP cord-001273-plz1ja2e 219 1 ( ( -LRB- cord-001273-plz1ja2e 219 2 Schwartz Schwartz NNP cord-001273-plz1ja2e 219 3 et et NNP cord-001273-plz1ja2e 219 4 al al NNP cord-001273-plz1ja2e 219 5 . . NNP cord-001273-plz1ja2e 219 6 , , , cord-001273-plz1ja2e 219 7 2012 2012 CD cord-001273-plz1ja2e 219 8 ; ; . cord-001273-plz1ja2e 220 1 Yamamoto Yamamoto NNP cord-001273-plz1ja2e 220 2 et et NNP cord-001273-plz1ja2e 220 3 al al NNP cord-001273-plz1ja2e 220 4 . . NNP cord-001273-plz1ja2e 220 5 , , , cord-001273-plz1ja2e 220 6 2012 2012 CD cord-001273-plz1ja2e 220 7 ) ) -RRB- cord-001273-plz1ja2e 220 8 . . . cord-001273-plz1ja2e 221 1 In in IN cord-001273-plz1ja2e 221 2 Listeria Listeria NNP cord-001273-plz1ja2e 221 3 , , , cord-001273-plz1ja2e 221 4 MdrT MdrT NNP cord-001273-plz1ja2e 221 5 allows allow VBZ cord-001273-plz1ja2e 221 6 secretion secretion NN cord-001273-plz1ja2e 221 7 of of IN cord-001273-plz1ja2e 221 8 cdi cdi NNP cord-001273-plz1ja2e 221 9 - - HYPH cord-001273-plz1ja2e 221 10 AMP AMP NNP cord-001273-plz1ja2e 221 11 , , , cord-001273-plz1ja2e 221 12 which which WDT cord-001273-plz1ja2e 221 13 triggers trigger VBZ cord-001273-plz1ja2e 221 14 IFN IFN NNP cord-001273-plz1ja2e 221 15 - - HYPH cord-001273-plz1ja2e 221 16 β β NNP cord-001273-plz1ja2e 221 17 . . . cord-001273-plz1ja2e 222 1 Thus thus RB cord-001273-plz1ja2e 222 2 , , , cord-001273-plz1ja2e 222 3 derepression derepression NN cord-001273-plz1ja2e 222 4 of of IN cord-001273-plz1ja2e 222 5 MdrT MdrT NNP cord-001273-plz1ja2e 222 6 in in IN cord-001273-plz1ja2e 222 7 the the DT cord-001273-plz1ja2e 222 8 LO28 LO28 NNP cord-001273-plz1ja2e 222 9 strain strain NN cord-001273-plz1ja2e 222 10 promotes promote VBZ cord-001273-plz1ja2e 222 11 IFN IFN NNP cord-001273-plz1ja2e 222 12 - - HYPH cord-001273-plz1ja2e 222 13 β β NNP cord-001273-plz1ja2e 222 14 production production NN cord-001273-plz1ja2e 222 15 . . . cord-001273-plz1ja2e 223 1 Of of IN cord-001273-plz1ja2e 223 2 note note VB cord-001273-plz1ja2e 223 3 , , , cord-001273-plz1ja2e 223 4 high high JJ cord-001273-plz1ja2e 223 5 expression expression NN cord-001273-plz1ja2e 223 6 of of IN cord-001273-plz1ja2e 223 7 MdrT MdrT NNP cord-001273-plz1ja2e 223 8 in in IN cord-001273-plz1ja2e 223 9 LO28 LO28 NNP cord-001273-plz1ja2e 223 10 correlates correlate VBZ cord-001273-plz1ja2e 223 11 with with IN cord-001273-plz1ja2e 223 12 both both DT cord-001273-plz1ja2e 223 13 induction induction NN cord-001273-plz1ja2e 223 14 of of IN cord-001273-plz1ja2e 223 15 IFN IFN NNP cord-001273-plz1ja2e 223 16 - - HYPH cord-001273-plz1ja2e 223 17 β β NNP cord-001273-plz1ja2e 223 18 and and CC cord-001273-plz1ja2e 223 19 lower low JJR cord-001273-plz1ja2e 223 20 virulence virulence NN cord-001273-plz1ja2e 223 21 . . . cord-001273-plz1ja2e 224 1 Another another DT cord-001273-plz1ja2e 224 2 Listeria Listeria NNP cord-001273-plz1ja2e 224 3 multidrug multidrug NN cord-001273-plz1ja2e 224 4 resistance resistance NN cord-001273-plz1ja2e 224 5 transporter transporter NN cord-001273-plz1ja2e 224 6 , , , cord-001273-plz1ja2e 224 7 MdrM MdrM NNP cord-001273-plz1ja2e 224 8 , , , cord-001273-plz1ja2e 224 9 has have VBZ cord-001273-plz1ja2e 224 10 been be VBN cord-001273-plz1ja2e 224 11 involved involve VBN cord-001273-plz1ja2e 224 12 in in IN cord-001273-plz1ja2e 224 13 the the DT cord-001273-plz1ja2e 224 14 stimulation stimulation NN cord-001273-plz1ja2e 224 15 of of IN cord-001273-plz1ja2e 224 16 IFN IFN NNP cord-001273-plz1ja2e 224 17 - - HYPH cord-001273-plz1ja2e 224 18 β β NNP cord-001273-plz1ja2e 224 19 production production NN cord-001273-plz1ja2e 224 20 , , , cord-001273-plz1ja2e 224 21 possibly possibly RB cord-001273-plz1ja2e 224 22 by by IN cord-001273-plz1ja2e 224 23 secreting secrete VBG cord-001273-plz1ja2e 224 24 c c NN cord-001273-plz1ja2e 224 25 - - HYPH cord-001273-plz1ja2e 224 26 di di FW cord-001273-plz1ja2e 224 27 - - HYPH cord-001273-plz1ja2e 224 28 AMP AMP NNP cord-001273-plz1ja2e 224 29 ( ( -LRB- cord-001273-plz1ja2e 224 30 Crimmins Crimmins NNP cord-001273-plz1ja2e 224 31 et et NNP cord-001273-plz1ja2e 224 32 al al NNP cord-001273-plz1ja2e 224 33 . . . cord-001273-plz1ja2e 225 1 , , , cord-001273-plz1ja2e 225 2 2008 2008 CD cord-001273-plz1ja2e 225 3 ; ; : cord-001273-plz1ja2e 225 4 Woodward Woodward NNP cord-001273-plz1ja2e 225 5 et et NNP cord-001273-plz1ja2e 225 6 al al NNP cord-001273-plz1ja2e 225 7 . . NNP cord-001273-plz1ja2e 225 8 , , , cord-001273-plz1ja2e 225 9 2010 2010 CD cord-001273-plz1ja2e 225 10 ; ; : cord-001273-plz1ja2e 225 11 Witte Witte NNP cord-001273-plz1ja2e 225 12 et et NNP cord-001273-plz1ja2e 225 13 al al NNP cord-001273-plz1ja2e 225 14 . . NNP cord-001273-plz1ja2e 225 15 , , , cord-001273-plz1ja2e 225 16 2012 2012 CD cord-001273-plz1ja2e 225 17 ) ) -RRB- cord-001273-plz1ja2e 225 18 . . . cord-001273-plz1ja2e 226 1 The the DT cord-001273-plz1ja2e 226 2 role role NN cord-001273-plz1ja2e 226 3 of of IN cord-001273-plz1ja2e 226 4 type type NN cord-001273-plz1ja2e 226 5 III III NNP cord-001273-plz1ja2e 226 6 - - HYPH cord-001273-plz1ja2e 226 7 IFNs ifn NNS cord-001273-plz1ja2e 226 8 during during IN cord-001273-plz1ja2e 226 9 listeriosis listeriosis NN cord-001273-plz1ja2e 226 10 remains remain VBZ cord-001273-plz1ja2e 226 11 to to TO cord-001273-plz1ja2e 226 12 be be VB cord-001273-plz1ja2e 226 13 determined determine VBN cord-001273-plz1ja2e 226 14 . . . cord-001273-plz1ja2e 227 1 Since since IN cord-001273-plz1ja2e 227 2 Listeria Listeria NNP cord-001273-plz1ja2e 227 3 colonizes colonize VBZ cord-001273-plz1ja2e 227 4 several several JJ cord-001273-plz1ja2e 227 5 tissues tissue NNS cord-001273-plz1ja2e 227 6 of of IN cord-001273-plz1ja2e 227 7 epithelial epithelial JJ cord-001273-plz1ja2e 227 8 origins origin NNS cord-001273-plz1ja2e 227 9 , , , cord-001273-plz1ja2e 227 10 such such JJ cord-001273-plz1ja2e 227 11 as as IN cord-001273-plz1ja2e 227 12 the the DT cord-001273-plz1ja2e 227 13 liver liver NN cord-001273-plz1ja2e 227 14 , , , cord-001273-plz1ja2e 227 15 intestine intestine NN cord-001273-plz1ja2e 227 16 and and CC cord-001273-plz1ja2e 227 17 placenta placenta NN cord-001273-plz1ja2e 227 18 , , , cord-001273-plz1ja2e 227 19 it -PRON- PRP cord-001273-plz1ja2e 227 20 is be VBZ cord-001273-plz1ja2e 227 21 tempting tempt VBG cord-001273-plz1ja2e 227 22 to to TO cord-001273-plz1ja2e 227 23 speculate speculate VB cord-001273-plz1ja2e 227 24 that that IN cord-001273-plz1ja2e 227 25 IFN IFN NNP cord-001273-plz1ja2e 227 26 - - HYPH cord-001273-plz1ja2e 227 27 λs λs NNP cord-001273-plz1ja2e 227 28 play play VBP cord-001273-plz1ja2e 227 29 a a DT cord-001273-plz1ja2e 227 30 role role NN cord-001273-plz1ja2e 227 31 in in IN cord-001273-plz1ja2e 227 32 the the DT cord-001273-plz1ja2e 227 33 interaction interaction NN cord-001273-plz1ja2e 227 34 of of IN cord-001273-plz1ja2e 227 35 Listeria Listeria NNP cord-001273-plz1ja2e 227 36 with with IN cord-001273-plz1ja2e 227 37 epithelia epithelium NNS cord-001273-plz1ja2e 227 38 . . . cord-001273-plz1ja2e 228 1 However however RB cord-001273-plz1ja2e 228 2 , , , cord-001273-plz1ja2e 228 3 a a DT cord-001273-plz1ja2e 228 4 prerequisite prerequisite NN cord-001273-plz1ja2e 228 5 to to TO cord-001273-plz1ja2e 228 6 address address VB cord-001273-plz1ja2e 228 7 this this DT cord-001273-plz1ja2e 228 8 question question NN cord-001273-plz1ja2e 228 9 is be VBZ cord-001273-plz1ja2e 228 10 the the DT cord-001273-plz1ja2e 228 11 establishment establishment NN cord-001273-plz1ja2e 228 12 of of IN cord-001273-plz1ja2e 228 13 a a DT cord-001273-plz1ja2e 228 14 new new JJ cord-001273-plz1ja2e 228 15 animal animal NN cord-001273-plz1ja2e 228 16 model model NN cord-001273-plz1ja2e 228 17 , , , cord-001273-plz1ja2e 228 18 i.e. i.e. FW cord-001273-plz1ja2e 228 19 , , , cord-001273-plz1ja2e 228 20 a a DT cord-001273-plz1ja2e 228 21 mouse mouse NN cord-001273-plz1ja2e 228 22 line line NN cord-001273-plz1ja2e 228 23 expressing express VBG cord-001273-plz1ja2e 228 24 a a DT cord-001273-plz1ja2e 228 25 human human JJ cord-001273-plz1ja2e 228 26 E e NN cord-001273-plz1ja2e 228 27 - - NN cord-001273-plz1ja2e 228 28 cadherin cadherin NN cord-001273-plz1ja2e 228 29 , , , cord-001273-plz1ja2e 228 30 thus thus RB cord-001273-plz1ja2e 228 31 permissive permissive JJ cord-001273-plz1ja2e 228 32 for for IN cord-001273-plz1ja2e 228 33 Listeria Listeria NNP cord-001273-plz1ja2e 228 34 infection infection NN cord-001273-plz1ja2e 228 35 of of IN cord-001273-plz1ja2e 228 36 epithelia epithelium NNS cord-001273-plz1ja2e 228 37 ( ( -LRB- cord-001273-plz1ja2e 228 38 Lecuit Lecuit NNP cord-001273-plz1ja2e 228 39 et et NNP cord-001273-plz1ja2e 228 40 al al NNP cord-001273-plz1ja2e 228 41 . . NNP cord-001273-plz1ja2e 228 42 , , , cord-001273-plz1ja2e 228 43 2001 2001 CD cord-001273-plz1ja2e 228 44 ) ) -RRB- cord-001273-plz1ja2e 228 45 and and CC cord-001273-plz1ja2e 228 46 impaired impair VBN cord-001273-plz1ja2e 228 47 in in IN cord-001273-plz1ja2e 228 48 type type NN cord-001273-plz1ja2e 228 49 III III NNP cord-001273-plz1ja2e 228 50 - - HYPH cord-001273-plz1ja2e 228 51 IFN IFN NNP cord-001273-plz1ja2e 228 52 responses response NNS cord-001273-plz1ja2e 228 53 , , , cord-001273-plz1ja2e 228 54 such such JJ cord-001273-plz1ja2e 228 55 as as IN cord-001273-plz1ja2e 228 56 IL28Rα IL28Rα NNP cord-001273-plz1ja2e 228 57 knockout knockout NN cord-001273-plz1ja2e 228 58 mice mouse NNS cord-001273-plz1ja2e 228 59 ( ( -LRB- cord-001273-plz1ja2e 228 60 Mordstein Mordstein NNP cord-001273-plz1ja2e 228 61 et et NNP cord-001273-plz1ja2e 228 62 al al NNP cord-001273-plz1ja2e 228 63 . . NNP cord-001273-plz1ja2e 228 64 , , , cord-001273-plz1ja2e 228 65 2010 2010 CD cord-001273-plz1ja2e 228 66 ) ) -RRB- cord-001273-plz1ja2e 228 67 . . . cord-001273-plz1ja2e 229 1 One one PRP cord-001273-plz1ja2e 229 2 should should MD cord-001273-plz1ja2e 229 3 keep keep VB cord-001273-plz1ja2e 229 4 in in IN cord-001273-plz1ja2e 229 5 mind mind NN cord-001273-plz1ja2e 229 6 that that IN cord-001273-plz1ja2e 229 7 the the DT cord-001273-plz1ja2e 229 8 mouse mouse NN cord-001273-plz1ja2e 229 9 model model NN cord-001273-plz1ja2e 229 10 is be VBZ cord-001273-plz1ja2e 229 11 not not RB cord-001273-plz1ja2e 229 12 optimal optimal JJ cord-001273-plz1ja2e 229 13 to to TO cord-001273-plz1ja2e 229 14 address address VB cord-001273-plz1ja2e 229 15 the the DT cord-001273-plz1ja2e 229 16 role role NN cord-001273-plz1ja2e 229 17 of of IN cord-001273-plz1ja2e 229 18 type type NN cord-001273-plz1ja2e 229 19 III III NNP cord-001273-plz1ja2e 229 20 - - HYPH cord-001273-plz1ja2e 229 21 IFN IFN NNP cord-001273-plz1ja2e 229 22 in in IN cord-001273-plz1ja2e 229 23 human human JJ cord-001273-plz1ja2e 229 24 listeriosis listeriosis NN cord-001273-plz1ja2e 229 25 . . . cord-001273-plz1ja2e 230 1 Indeed indeed RB cord-001273-plz1ja2e 230 2 , , , cord-001273-plz1ja2e 230 3 IFN IFN NNP cord-001273-plz1ja2e 230 4 - - HYPH cord-001273-plz1ja2e 230 5 λ1 λ1 NNP cord-001273-plz1ja2e 230 6 is be VBZ cord-001273-plz1ja2e 230 7 a a DT cord-001273-plz1ja2e 230 8 pseudogene pseudogene NN cord-001273-plz1ja2e 230 9 in in IN cord-001273-plz1ja2e 230 10 mice mouse NNS cord-001273-plz1ja2e 230 11 , , , cord-001273-plz1ja2e 230 12 while while IN cord-001273-plz1ja2e 230 13 human human JJ cord-001273-plz1ja2e 230 14 cells cell NNS cord-001273-plz1ja2e 230 15 produce produce VBP cord-001273-plz1ja2e 230 16 this this DT cord-001273-plz1ja2e 230 17 cytokine cytokine NN cord-001273-plz1ja2e 230 18 upon upon IN cord-001273-plz1ja2e 230 19 infection infection NN cord-001273-plz1ja2e 230 20 with with IN cord-001273-plz1ja2e 230 21 L. L. NNP cord-001273-plz1ja2e 230 22 monocytogenes monocytogene NNS cord-001273-plz1ja2e 230 23 . . . cord-001273-plz1ja2e 231 1 In in IN cord-001273-plz1ja2e 231 2 addition addition NN cord-001273-plz1ja2e 231 3 , , , cord-001273-plz1ja2e 231 4 the the DT cord-001273-plz1ja2e 231 5 type type NN cord-001273-plz1ja2e 231 6 III III NNP cord-001273-plz1ja2e 231 7 - - HYPH cord-001273-plz1ja2e 231 8 IFN IFN NNP cord-001273-plz1ja2e 231 9 receptor receptor NN cord-001273-plz1ja2e 231 10 is be VBZ cord-001273-plz1ja2e 231 11 expressed express VBN cord-001273-plz1ja2e 231 12 at at IN cord-001273-plz1ja2e 231 13 very very RB cord-001273-plz1ja2e 231 14 low low JJ cord-001273-plz1ja2e 231 15 levels level NNS cord-001273-plz1ja2e 231 16 in in IN cord-001273-plz1ja2e 231 17 the the DT cord-001273-plz1ja2e 231 18 mouse mouse NN cord-001273-plz1ja2e 231 19 liver liver NN cord-001273-plz1ja2e 231 20 and and CC cord-001273-plz1ja2e 231 21 the the DT cord-001273-plz1ja2e 231 22 IFN IFN NNP cord-001273-plz1ja2e 231 23 - - HYPH cord-001273-plz1ja2e 231 24 λ λ NNP cord-001273-plz1ja2e 231 25 response response NN cord-001273-plz1ja2e 231 26 of of IN cord-001273-plz1ja2e 231 27 the the DT cord-001273-plz1ja2e 231 28 mouse mouse NN cord-001273-plz1ja2e 231 29 liver liver NN cord-001273-plz1ja2e 231 30 is be VBZ cord-001273-plz1ja2e 231 31 very very RB cord-001273-plz1ja2e 231 32 weak weak JJ cord-001273-plz1ja2e 232 1 ( ( -LRB- cord-001273-plz1ja2e 232 2 Mordstein Mordstein NNP cord-001273-plz1ja2e 232 3 et et NNP cord-001273-plz1ja2e 232 4 al al NNP cord-001273-plz1ja2e 232 5 . . NNP cord-001273-plz1ja2e 232 6 , , , cord-001273-plz1ja2e 232 7 2010 2010 CD cord-001273-plz1ja2e 232 8 ) ) -RRB- cord-001273-plz1ja2e 232 9 . . . cord-001273-plz1ja2e 233 1 In in IN cord-001273-plz1ja2e 233 2 line line NN cord-001273-plz1ja2e 233 3 with with IN cord-001273-plz1ja2e 233 4 this this DT cord-001273-plz1ja2e 233 5 , , , cord-001273-plz1ja2e 233 6 it -PRON- PRP cord-001273-plz1ja2e 233 7 has have VBZ cord-001273-plz1ja2e 233 8 been be VBN cord-001273-plz1ja2e 233 9 recently recently RB cord-001273-plz1ja2e 233 10 shown show VBN cord-001273-plz1ja2e 233 11 that that IN cord-001273-plz1ja2e 233 12 mouse mouse NN cord-001273-plz1ja2e 233 13 hepatocytes hepatocyte NNS cord-001273-plz1ja2e 233 14 , , , cord-001273-plz1ja2e 233 15 in in IN cord-001273-plz1ja2e 233 16 contrast contrast NN cord-001273-plz1ja2e 233 17 to to IN cord-001273-plz1ja2e 233 18 human human JJ cord-001273-plz1ja2e 233 19 hepatocytes hepatocyte NNS cord-001273-plz1ja2e 233 20 , , , cord-001273-plz1ja2e 233 21 are be VBP cord-001273-plz1ja2e 233 22 not not RB cord-001273-plz1ja2e 233 23 responsive responsive JJ cord-001273-plz1ja2e 233 24 to to IN cord-001273-plz1ja2e 233 25 IFN IFN NNP cord-001273-plz1ja2e 233 26 - - HYPH cord-001273-plz1ja2e 233 27 λ λ NNP cord-001273-plz1ja2e 234 1 ( ( -LRB- cord-001273-plz1ja2e 234 2 Hermant Hermant NNP cord-001273-plz1ja2e 234 3 et et FW cord-001273-plz1ja2e 234 4 al al NNP cord-001273-plz1ja2e 234 5 . . . cord-001273-plz1ja2e 235 1 , , , cord-001273-plz1ja2e 235 2 2014 2014 CD cord-001273-plz1ja2e 235 3 ) ) -RRB- cord-001273-plz1ja2e 235 4 . . . cord-001273-plz1ja2e 236 1 The the DT cord-001273-plz1ja2e 236 2 beneficial beneficial JJ cord-001273-plz1ja2e 236 3 or or CC cord-001273-plz1ja2e 236 4 detrimental detrimental JJ cord-001273-plz1ja2e 236 5 effects effect NNS cord-001273-plz1ja2e 236 6 of of IN cord-001273-plz1ja2e 236 7 IFNs ifn NNS cord-001273-plz1ja2e 236 8 on on IN cord-001273-plz1ja2e 236 9 Listeria Listeria NNP cord-001273-plz1ja2e 236 10 infection infection NN cord-001273-plz1ja2e 236 11 rely rely VBP cord-001273-plz1ja2e 236 12 on on IN cord-001273-plz1ja2e 236 13 the the DT cord-001273-plz1ja2e 236 14 functional functional JJ cord-001273-plz1ja2e 236 15 properties property NNS cord-001273-plz1ja2e 236 16 of of IN cord-001273-plz1ja2e 236 17 their -PRON- PRP$ cord-001273-plz1ja2e 236 18 downstream downstream JJ cord-001273-plz1ja2e 236 19 effectors effector NNS cord-001273-plz1ja2e 236 20 . . . cord-001273-plz1ja2e 237 1 Indeed indeed RB cord-001273-plz1ja2e 237 2 , , , cord-001273-plz1ja2e 237 3 IFNs ifn NNS cord-001273-plz1ja2e 237 4 elicit elicit VBP cord-001273-plz1ja2e 237 5 expression expression NN cord-001273-plz1ja2e 237 6 of of IN cord-001273-plz1ja2e 237 7 hundreds hundred NNS cord-001273-plz1ja2e 237 8 of of IN cord-001273-plz1ja2e 237 9 interferonstimulated interferonstimulate VBN cord-001273-plz1ja2e 237 10 genes gene NNS cord-001273-plz1ja2e 237 11 ( ( -LRB- cord-001273-plz1ja2e 237 12 ISGs ISGs NNP cord-001273-plz1ja2e 237 13 ) ) -RRB- cord-001273-plz1ja2e 237 14 , , , cord-001273-plz1ja2e 237 15 which which WDT cord-001273-plz1ja2e 237 16 encode encode VBP cord-001273-plz1ja2e 237 17 proteins protein NNS cord-001273-plz1ja2e 237 18 involved involve VBN cord-001273-plz1ja2e 237 19 in in IN cord-001273-plz1ja2e 237 20 a a DT cord-001273-plz1ja2e 237 21 broad broad JJ cord-001273-plz1ja2e 237 22 range range NN cord-001273-plz1ja2e 237 23 of of IN cord-001273-plz1ja2e 237 24 cellular cellular JJ cord-001273-plz1ja2e 237 25 functions function NNS cord-001273-plz1ja2e 237 26 ( ( -LRB- cord-001273-plz1ja2e 237 27 reviewed review VBN cord-001273-plz1ja2e 237 28 in in IN cord-001273-plz1ja2e 237 29 MacMicking MacMicking NNP cord-001273-plz1ja2e 237 30 , , , cord-001273-plz1ja2e 237 31 2004 2004 CD cord-001273-plz1ja2e 237 32 ) ) -RRB- cord-001273-plz1ja2e 237 33 . . . cord-001273-plz1ja2e 238 1 However however RB cord-001273-plz1ja2e 238 2 , , , cord-001273-plz1ja2e 238 3 while while IN cord-001273-plz1ja2e 238 4 about about RB cord-001273-plz1ja2e 238 5 2,000 2,000 CD cord-001273-plz1ja2e 238 6 ISGs ISGs NNPS cord-001273-plz1ja2e 238 7 have have VBP cord-001273-plz1ja2e 238 8 been be VBN cord-001273-plz1ja2e 238 9 identified identify VBN cord-001273-plz1ja2e 238 10 so so RB cord-001273-plz1ja2e 238 11 far far RB cord-001273-plz1ja2e 239 1 ( ( -LRB- cord-001273-plz1ja2e 239 2 Rusinova Rusinova NNP cord-001273-plz1ja2e 239 3 et et NNP cord-001273-plz1ja2e 239 4 al al NNP cord-001273-plz1ja2e 239 5 . . NNP cord-001273-plz1ja2e 239 6 , , , cord-001273-plz1ja2e 239 7 2012 2012 CD cord-001273-plz1ja2e 239 8 ) ) -RRB- cord-001273-plz1ja2e 239 9 , , , cord-001273-plz1ja2e 239 10 their -PRON- PRP$ cord-001273-plz1ja2e 239 11 functions function NNS cord-001273-plz1ja2e 239 12 in in IN cord-001273-plz1ja2e 239 13 immunomodulation immunomodulation NN cord-001273-plz1ja2e 239 14 remain remain VBP cord-001273-plz1ja2e 239 15 to to TO cord-001273-plz1ja2e 239 16 be be VB cord-001273-plz1ja2e 239 17 characterized characterize VBN cord-001273-plz1ja2e 239 18 . . . cord-001273-plz1ja2e 240 1 To to IN cord-001273-plz1ja2e 240 2 date date NN cord-001273-plz1ja2e 240 3 , , , cord-001273-plz1ja2e 240 4 the the DT cord-001273-plz1ja2e 240 5 contribution contribution NN cord-001273-plz1ja2e 240 6 of of IN cord-001273-plz1ja2e 240 7 interferon interferon NN cord-001273-plz1ja2e 240 8 - - HYPH cord-001273-plz1ja2e 240 9 induced induce VBN cord-001273-plz1ja2e 240 10 proteins protein NNS cord-001273-plz1ja2e 240 11 on on IN cord-001273-plz1ja2e 240 12 Listeria Listeria NNP cord-001273-plz1ja2e 240 13 infection infection NN cord-001273-plz1ja2e 240 14 has have VBZ cord-001273-plz1ja2e 240 15 mostly mostly RB cord-001273-plz1ja2e 240 16 been be VBN cord-001273-plz1ja2e 240 17 studied study VBN cord-001273-plz1ja2e 240 18 in in IN cord-001273-plz1ja2e 240 19 the the DT cord-001273-plz1ja2e 240 20 context context NN cord-001273-plz1ja2e 240 21 of of IN cord-001273-plz1ja2e 240 22 the the DT cord-001273-plz1ja2e 240 23 IFN IFN NNP cord-001273-plz1ja2e 240 24 - - HYPH cord-001273-plz1ja2e 240 25 γ γ NNP cord-001273-plz1ja2e 240 26 pathway pathway NN cord-001273-plz1ja2e 240 27 . . . cord-001273-plz1ja2e 241 1 The the DT cord-001273-plz1ja2e 241 2 antilisterial antilisterial JJ cord-001273-plz1ja2e 241 3 activity activity NN cord-001273-plz1ja2e 241 4 of of IN cord-001273-plz1ja2e 241 5 IFN IFN NNP cord-001273-plz1ja2e 241 6 - - HYPH cord-001273-plz1ja2e 241 7 γ γ NNP cord-001273-plz1ja2e 241 8 in in IN cord-001273-plz1ja2e 241 9 phagocytic phagocytic JJ cord-001273-plz1ja2e 241 10 cells cell NNS cord-001273-plz1ja2e 241 11 involves involve VBZ cord-001273-plz1ja2e 241 12 induction induction NN cord-001273-plz1ja2e 241 13 of of IN cord-001273-plz1ja2e 241 14 oxidative oxidative JJ cord-001273-plz1ja2e 241 15 and and CC cord-001273-plz1ja2e 241 16 nitrosative nitrosative JJ cord-001273-plz1ja2e 241 17 defences defence NNS cord-001273-plz1ja2e 241 18 , , , cord-001273-plz1ja2e 241 19 via via IN cord-001273-plz1ja2e 241 20 increased increase VBN cord-001273-plz1ja2e 241 21 expression expression NN cord-001273-plz1ja2e 241 22 of of IN cord-001273-plz1ja2e 241 23 enzymes enzyme NNS cord-001273-plz1ja2e 241 24 that that WDT cord-001273-plz1ja2e 241 25 control control VBP cord-001273-plz1ja2e 241 26 production production NN cord-001273-plz1ja2e 241 27 of of IN cord-001273-plz1ja2e 241 28 reactive reactive JJ cord-001273-plz1ja2e 241 29 oxygen oxygen NN cord-001273-plz1ja2e 241 30 and and CC cord-001273-plz1ja2e 241 31 nitrogen nitrogen NN cord-001273-plz1ja2e 241 32 species specie NNS cord-001273-plz1ja2e 241 33 , , , cord-001273-plz1ja2e 241 34 such such JJ cord-001273-plz1ja2e 241 35 as as IN cord-001273-plz1ja2e 241 36 NOX2 NOX2 NNP cord-001273-plz1ja2e 241 37 / / SYM cord-001273-plz1ja2e 241 38 CYBB CYBB NNP cord-001273-plz1ja2e 241 39 , , , cord-001273-plz1ja2e 241 40 DUOX2 duox2 NN cord-001273-plz1ja2e 241 41 , , , cord-001273-plz1ja2e 241 42 and and CC cord-001273-plz1ja2e 241 43 iNOS/ iNOS/ . cord-001273-plz1ja2e 242 1 NOS2 NOS2 NNP cord-001273-plz1ja2e 242 2 ( ( -LRB- cord-001273-plz1ja2e 242 3 MacMicking MacMicking NNP cord-001273-plz1ja2e 242 4 , , , cord-001273-plz1ja2e 242 5 2012 2012 CD cord-001273-plz1ja2e 242 6 ) ) -RRB- cord-001273-plz1ja2e 242 7 . . . cord-001273-plz1ja2e 243 1 These these DT cord-001273-plz1ja2e 243 2 enzymes enzyme NNS cord-001273-plz1ja2e 243 3 play play VBP cord-001273-plz1ja2e 243 4 an an DT cord-001273-plz1ja2e 243 5 important important JJ cord-001273-plz1ja2e 243 6 role role NN cord-001273-plz1ja2e 243 7 in in IN cord-001273-plz1ja2e 243 8 protecting protect VBG cord-001273-plz1ja2e 243 9 infected infected JJ cord-001273-plz1ja2e 243 10 cells cell NNS cord-001273-plz1ja2e 243 11 against against IN cord-001273-plz1ja2e 243 12 Listeria Listeria NNP cord-001273-plz1ja2e 243 13 cytoinvasion cytoinvasion NN cord-001273-plz1ja2e 243 14 ( ( -LRB- cord-001273-plz1ja2e 243 15 Myers Myers NNP cord-001273-plz1ja2e 243 16 et et NNP cord-001273-plz1ja2e 243 17 al al NNP cord-001273-plz1ja2e 243 18 . . NNP cord-001273-plz1ja2e 243 19 , , , cord-001273-plz1ja2e 243 20 2003 2003 CD cord-001273-plz1ja2e 243 21 ; ; : cord-001273-plz1ja2e 243 22 Lipinski Lipinski NNP cord-001273-plz1ja2e 243 23 et et NNP cord-001273-plz1ja2e 243 24 al al NNP cord-001273-plz1ja2e 243 25 . . NNP cord-001273-plz1ja2e 243 26 , , , cord-001273-plz1ja2e 243 27 2009 2009 CD cord-001273-plz1ja2e 243 28 ) ) -RRB- cord-001273-plz1ja2e 243 29 . . . cord-001273-plz1ja2e 244 1 The the DT cord-001273-plz1ja2e 244 2 assembly assembly NN cord-001273-plz1ja2e 244 3 of of IN cord-001273-plz1ja2e 244 4 these these DT cord-001273-plz1ja2e 244 5 enzymes enzyme NNS cord-001273-plz1ja2e 244 6 requires require VBZ cord-001273-plz1ja2e 244 7 IFN IFN NNP cord-001273-plz1ja2e 244 8 - - HYPH cord-001273-plz1ja2e 244 9 γ γ NN cord-001273-plz1ja2e 244 10 - - HYPH cord-001273-plz1ja2e 244 11 inducible inducible JJ cord-001273-plz1ja2e 244 12 guanosine guanosine NN cord-001273-plz1ja2e 244 13 triphosphatases triphosphatase NNS cord-001273-plz1ja2e 244 14 ( ( -LRB- cord-001273-plz1ja2e 244 15 GTPases GTPases NNP cord-001273-plz1ja2e 244 16 ) ) -RRB- cord-001273-plz1ja2e 244 17 of of IN cord-001273-plz1ja2e 244 18 the the DT cord-001273-plz1ja2e 244 19 Gbp Gbp NNP cord-001273-plz1ja2e 244 20 ( ( -LRB- cord-001273-plz1ja2e 244 21 guanylate guanylate NN cord-001273-plz1ja2e 244 22 binding bind VBG cord-001273-plz1ja2e 244 23 protein protein NN cord-001273-plz1ja2e 244 24 ) ) -RRB- cord-001273-plz1ja2e 244 25 family family NN cord-001273-plz1ja2e 244 26 ( ( -LRB- cord-001273-plz1ja2e 244 27 Boehm Boehm NNP cord-001273-plz1ja2e 244 28 et et NNP cord-001273-plz1ja2e 244 29 al al NNP cord-001273-plz1ja2e 244 30 . . NNP cord-001273-plz1ja2e 244 31 , , , cord-001273-plz1ja2e 244 32 1998 1998 CD cord-001273-plz1ja2e 244 33 ) ) -RRB- cord-001273-plz1ja2e 244 34 , , , cord-001273-plz1ja2e 244 35 which which WDT cord-001273-plz1ja2e 244 36 not not RB cord-001273-plz1ja2e 244 37 only only RB cord-001273-plz1ja2e 244 38 participate participate VBP cord-001273-plz1ja2e 244 39 to to IN cord-001273-plz1ja2e 244 40 oxidative oxidative JJ cord-001273-plz1ja2e 244 41 pathways pathway NNS cord-001273-plz1ja2e 244 42 but but CC cord-001273-plz1ja2e 244 43 also also RB cord-001273-plz1ja2e 244 44 regulate regulate VBP cord-001273-plz1ja2e 244 45 autophagy autophagy NN cord-001273-plz1ja2e 244 46 ( ( -LRB- cord-001273-plz1ja2e 244 47 Kim Kim NNP cord-001273-plz1ja2e 244 48 et et NNP cord-001273-plz1ja2e 244 49 al al NNP cord-001273-plz1ja2e 244 50 . . NNP cord-001273-plz1ja2e 244 51 , , , cord-001273-plz1ja2e 244 52 2011 2011 CD cord-001273-plz1ja2e 244 53 ) ) -RRB- cord-001273-plz1ja2e 244 54 . . . cord-001273-plz1ja2e 245 1 Several several JJ cord-001273-plz1ja2e 245 2 Gbps Gbps NNP cord-001273-plz1ja2e 245 3 have have VBP cord-001273-plz1ja2e 245 4 been be VBN cord-001273-plz1ja2e 245 5 shown show VBN cord-001273-plz1ja2e 245 6 to to TO cord-001273-plz1ja2e 245 7 protect protect VB cord-001273-plz1ja2e 245 8 cells cell NNS cord-001273-plz1ja2e 245 9 from from IN cord-001273-plz1ja2e 245 10 Listeria Listeria NNP cord-001273-plz1ja2e 245 11 infection infection NN cord-001273-plz1ja2e 245 12 by by IN cord-001273-plz1ja2e 245 13 coordinating coordinate VBG cord-001273-plz1ja2e 245 14 a a DT cord-001273-plz1ja2e 245 15 potent potent JJ cord-001273-plz1ja2e 245 16 oxidative oxidative JJ cord-001273-plz1ja2e 245 17 and and CC cord-001273-plz1ja2e 245 18 vesicular vesicular JJ cord-001273-plz1ja2e 245 19 trafficking trafficking NN cord-001273-plz1ja2e 245 20 program program NN cord-001273-plz1ja2e 246 1 ( ( -LRB- cord-001273-plz1ja2e 246 2 Kim Kim NNP cord-001273-plz1ja2e 246 3 et et NNP cord-001273-plz1ja2e 246 4 al al NNP cord-001273-plz1ja2e 246 5 . . NNP cord-001273-plz1ja2e 246 6 , , , cord-001273-plz1ja2e 246 7 2011 2011 CD cord-001273-plz1ja2e 246 8 ) ) -RRB- cord-001273-plz1ja2e 246 9 . . . cord-001273-plz1ja2e 247 1 IFN IFN NNP cord-001273-plz1ja2e 247 2 - - HYPH cord-001273-plz1ja2e 247 3 γ γ NNP cord-001273-plz1ja2e 247 4 also also RB cord-001273-plz1ja2e 247 5 induces induce VBZ cord-001273-plz1ja2e 247 6 the the DT cord-001273-plz1ja2e 247 7 expression expression NN cord-001273-plz1ja2e 247 8 of of IN cord-001273-plz1ja2e 247 9 many many JJ cord-001273-plz1ja2e 247 10 nuclear nuclear JJ cord-001273-plz1ja2e 247 11 genes gene NNS cord-001273-plz1ja2e 247 12 encoding encode VBG cord-001273-plz1ja2e 247 13 mitochondrial mitochondrial JJ cord-001273-plz1ja2e 247 14 respiratory respiratory JJ cord-001273-plz1ja2e 247 15 chain chain NN cord-001273-plz1ja2e 247 16 machinery machinery NN cord-001273-plz1ja2e 247 17 , , , cord-001273-plz1ja2e 247 18 via via IN cord-001273-plz1ja2e 247 19 activation activation NN cord-001273-plz1ja2e 247 20 of of IN cord-001273-plz1ja2e 247 21 the the DT cord-001273-plz1ja2e 247 22 nuclear nuclear JJ cord-001273-plz1ja2e 247 23 receptor receptor NN cord-001273-plz1ja2e 247 24 ERRα ERRα NNS cord-001273-plz1ja2e 247 25 ( ( -LRB- cord-001273-plz1ja2e 247 26 estrogen estrogen NN cord-001273-plz1ja2e 247 27 - - HYPH cord-001273-plz1ja2e 247 28 related relate VBN cord-001273-plz1ja2e 247 29 receptor receptor NN cord-001273-plz1ja2e 247 30 α α NN cord-001273-plz1ja2e 247 31 ) ) -RRB- cord-001273-plz1ja2e 247 32 . . . cord-001273-plz1ja2e 248 1 ERRα ERRα NNP cord-001273-plz1ja2e 248 2 contributes contribute VBZ cord-001273-plz1ja2e 248 3 to to IN cord-001273-plz1ja2e 248 4 mitochondrial mitochondrial JJ cord-001273-plz1ja2e 248 5 ROS ROS NNP cord-001273-plz1ja2e 248 6 production production NN cord-001273-plz1ja2e 248 7 and and CC cord-001273-plz1ja2e 248 8 efficient efficient JJ cord-001273-plz1ja2e 248 9 clearance clearance NN cord-001273-plz1ja2e 248 10 of of IN cord-001273-plz1ja2e 248 11 L. L. NNP cord-001273-plz1ja2e 248 12 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 248 13 ( ( -LRB- cord-001273-plz1ja2e 248 14 Sonoda Sonoda NNP cord-001273-plz1ja2e 248 15 et et NNP cord-001273-plz1ja2e 248 16 al al NNP cord-001273-plz1ja2e 248 17 . . NNP cord-001273-plz1ja2e 248 18 , , , cord-001273-plz1ja2e 248 19 2007 2007 CD cord-001273-plz1ja2e 248 20 ) ) -RRB- cord-001273-plz1ja2e 248 21 . . . cord-001273-plz1ja2e 249 1 A a DT cord-001273-plz1ja2e 249 2 family family NN cord-001273-plz1ja2e 249 3 of of IN cord-001273-plz1ja2e 249 4 IFN IFN NNP cord-001273-plz1ja2e 249 5 - - HYPH cord-001273-plz1ja2e 249 6 γ γ NNP cord-001273-plz1ja2e 249 7 - - HYPH cord-001273-plz1ja2e 249 8 induced induce VBN cord-001273-plz1ja2e 249 9 chemokines chemokine NNS cord-001273-plz1ja2e 249 10 ( ( -LRB- cord-001273-plz1ja2e 249 11 CXCL9 CXCL9 NNP cord-001273-plz1ja2e 249 12 , , , cord-001273-plz1ja2e 249 13 CXCL10 CXCL10 NNP cord-001273-plz1ja2e 249 14 , , , cord-001273-plz1ja2e 249 15 CXCL11 CXCL11 NNP cord-001273-plz1ja2e 249 16 ) ) -RRB- cord-001273-plz1ja2e 249 17 displays display VBZ cord-001273-plz1ja2e 249 18 direct direct JJ cord-001273-plz1ja2e 249 19 antimicrobial antimicrobial JJ cord-001273-plz1ja2e 249 20 activity activity NN cord-001273-plz1ja2e 249 21 against against IN cord-001273-plz1ja2e 249 22 L. L. NNP cord-001273-plz1ja2e 249 23 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 249 24 ( ( -LRB- cord-001273-plz1ja2e 249 25 Cole Cole NNP cord-001273-plz1ja2e 249 26 et et NNP cord-001273-plz1ja2e 249 27 al al NNP cord-001273-plz1ja2e 249 28 . . NNP cord-001273-plz1ja2e 249 29 , , , cord-001273-plz1ja2e 249 30 2001 2001 CD cord-001273-plz1ja2e 249 31 ) ) -RRB- cord-001273-plz1ja2e 249 32 . . . cord-001273-plz1ja2e 250 1 In in IN cord-001273-plz1ja2e 250 2 dendritic dendritic JJ cord-001273-plz1ja2e 250 3 cells cell NNS cord-001273-plz1ja2e 250 4 , , , cord-001273-plz1ja2e 250 5 one one CD cord-001273-plz1ja2e 250 6 of of IN cord-001273-plz1ja2e 250 7 the the DT cord-001273-plz1ja2e 250 8 IFN IFN NNP cord-001273-plz1ja2e 250 9 - - HYPH cord-001273-plz1ja2e 250 10 γ γ NNP cord-001273-plz1ja2e 250 11 - - HYPH cord-001273-plz1ja2e 250 12 associated associate VBN cord-001273-plz1ja2e 250 13 ISGs ISGs NNP cord-001273-plz1ja2e 250 14 is be VBZ cord-001273-plz1ja2e 250 15 the the DT cord-001273-plz1ja2e 250 16 immunoregulatory immunoregulatory NNP cord-001273-plz1ja2e 250 17 enzyme enzyme NNP cord-001273-plz1ja2e 250 18 indoleamine indoleamine NNP cord-001273-plz1ja2e 250 19 2,3-dioxygenase 2,3-dioxygenase NNP cord-001273-plz1ja2e 250 20 ( ( -LRB- cord-001273-plz1ja2e 250 21 IDO IDO NNP cord-001273-plz1ja2e 250 22 ) ) -RRB- cord-001273-plz1ja2e 250 23 , , , cord-001273-plz1ja2e 250 24 a a DT cord-001273-plz1ja2e 250 25 key key JJ cord-001273-plz1ja2e 250 26 enzyme enzyme NN cord-001273-plz1ja2e 250 27 of of IN cord-001273-plz1ja2e 250 28 the the DT cord-001273-plz1ja2e 250 29 tryptophan tryptophan NN cord-001273-plz1ja2e 250 30 metabolism metabolism NN cord-001273-plz1ja2e 250 31 . . . cord-001273-plz1ja2e 251 1 IDO IDO NNP cord-001273-plz1ja2e 251 2 is be VBZ cord-001273-plz1ja2e 251 3 proposed propose VBN cord-001273-plz1ja2e 251 4 to to TO cord-001273-plz1ja2e 251 5 play play VB cord-001273-plz1ja2e 251 6 a a DT cord-001273-plz1ja2e 251 7 role role NN cord-001273-plz1ja2e 251 8 in in IN cord-001273-plz1ja2e 251 9 the the DT cord-001273-plz1ja2e 251 10 containment containment NN cord-001273-plz1ja2e 251 11 of of IN cord-001273-plz1ja2e 251 12 Listeria Listeria NNP cord-001273-plz1ja2e 251 13 within within IN cord-001273-plz1ja2e 251 14 granulomatous granulomatous JJ cord-001273-plz1ja2e 251 15 structures structure NNS cord-001273-plz1ja2e 251 16 , , , cord-001273-plz1ja2e 251 17 thus thus RB cord-001273-plz1ja2e 251 18 avoiding avoid VBG cord-001273-plz1ja2e 251 19 massive massive JJ cord-001273-plz1ja2e 251 20 T T NNP cord-001273-plz1ja2e 251 21 cell cell NN cord-001273-plz1ja2e 251 22 activation activation NN cord-001273-plz1ja2e 251 23 ( ( -LRB- cord-001273-plz1ja2e 251 24 Popov Popov NNP cord-001273-plz1ja2e 251 25 et et NNP cord-001273-plz1ja2e 251 26 al al NNP cord-001273-plz1ja2e 251 27 . . NNP cord-001273-plz1ja2e 251 28 , , , cord-001273-plz1ja2e 251 29 2006 2006 CD cord-001273-plz1ja2e 251 30 ) ) -RRB- cord-001273-plz1ja2e 251 31 . . . cord-001273-plz1ja2e 252 1 The the DT cord-001273-plz1ja2e 252 2 function function NN cord-001273-plz1ja2e 252 3 of of IN cord-001273-plz1ja2e 252 4 type type NN cord-001273-plz1ja2e 252 5 I -PRON- PRP cord-001273-plz1ja2e 252 6 IFN IFN NNP cord-001273-plz1ja2e 252 7 - - HYPH cord-001273-plz1ja2e 252 8 associated associate VBD cord-001273-plz1ja2e 252 9 ISGs ISGs NNP cord-001273-plz1ja2e 252 10 in in IN cord-001273-plz1ja2e 252 11 Listeria Listeria NNP cord-001273-plz1ja2e 252 12 infection infection NN cord-001273-plz1ja2e 252 13 is be VBZ cord-001273-plz1ja2e 252 14 less less RBR cord-001273-plz1ja2e 252 15 documented document VBN cord-001273-plz1ja2e 252 16 . . . cord-001273-plz1ja2e 253 1 Zwaferink Zwaferink NNP cord-001273-plz1ja2e 253 2 et et NNP cord-001273-plz1ja2e 253 3 al al NNP cord-001273-plz1ja2e 253 4 . . NNP cord-001273-plz1ja2e 253 5 have have VBP cord-001273-plz1ja2e 253 6 observed observe VBN cord-001273-plz1ja2e 253 7 that that IN cord-001273-plz1ja2e 253 8 upregulation upregulation NN cord-001273-plz1ja2e 253 9 of of IN cord-001273-plz1ja2e 253 10 iNOS inos CD cord-001273-plz1ja2e 253 11 / / SYM cord-001273-plz1ja2e 253 12 NOS2 NOS2 NNP cord-001273-plz1ja2e 253 13 by by IN cord-001273-plz1ja2e 253 14 IFN IFN NNP cord-001273-plz1ja2e 253 15 - - HYPH cord-001273-plz1ja2e 253 16 β β NNP cord-001273-plz1ja2e 253 17 promotes promote VBZ cord-001273-plz1ja2e 253 18 necrotic necrotic JJ cord-001273-plz1ja2e 253 19 death death NN cord-001273-plz1ja2e 253 20 of of IN cord-001273-plz1ja2e 253 21 macrophages macrophage NNS cord-001273-plz1ja2e 254 1 ( ( -LRB- cord-001273-plz1ja2e 254 2 Zwaferink Zwaferink NNP cord-001273-plz1ja2e 254 3 et et NNP cord-001273-plz1ja2e 254 4 al al NNP cord-001273-plz1ja2e 254 5 . . NNP cord-001273-plz1ja2e 254 6 , , , cord-001273-plz1ja2e 254 7 2007 2007 CD cord-001273-plz1ja2e 254 8 ) ) -RRB- cord-001273-plz1ja2e 254 9 . . . cord-001273-plz1ja2e 255 1 Additionally additionally RB cord-001273-plz1ja2e 255 2 , , , cord-001273-plz1ja2e 255 3 several several JJ cord-001273-plz1ja2e 255 4 interferon interferon NN cord-001273-plz1ja2e 255 5 - - HYPH cord-001273-plz1ja2e 255 6 inducible inducible JJ cord-001273-plz1ja2e 255 7 proteins protein NNS cord-001273-plz1ja2e 255 8 belong belong VBP cord-001273-plz1ja2e 255 9 to to IN cord-001273-plz1ja2e 255 10 inflammasomes inflammasome NNS cord-001273-plz1ja2e 255 11 ; ; : cord-001273-plz1ja2e 255 12 thus thus RB cord-001273-plz1ja2e 255 13 , , , cord-001273-plz1ja2e 255 14 type type NN cord-001273-plz1ja2e 255 15 I -PRON- PRP cord-001273-plz1ja2e 255 16 IFN IFN NNP cord-001273-plz1ja2e 255 17 may may MD cord-001273-plz1ja2e 255 18 potentiate potentiate VB cord-001273-plz1ja2e 255 19 inflammasome inflammasome NN cord-001273-plz1ja2e 255 20 activation activation NN cord-001273-plz1ja2e 255 21 and and CC cord-001273-plz1ja2e 255 22 cell cell NN cord-001273-plz1ja2e 255 23 death death NN cord-001273-plz1ja2e 255 24 by by IN cord-001273-plz1ja2e 255 25 pyroptosis pyroptosis NN cord-001273-plz1ja2e 255 26 ( ( -LRB- cord-001273-plz1ja2e 255 27 Malireddi Malireddi NNP cord-001273-plz1ja2e 255 28 and and CC cord-001273-plz1ja2e 255 29 Kanneganti Kanneganti NNP cord-001273-plz1ja2e 255 30 , , , cord-001273-plz1ja2e 255 31 2013 2013 CD cord-001273-plz1ja2e 255 32 ) ) -RRB- cord-001273-plz1ja2e 255 33 . . . cord-001273-plz1ja2e 256 1 Yet yet RB cord-001273-plz1ja2e 256 2 , , , cord-001273-plz1ja2e 256 3 the the DT cord-001273-plz1ja2e 256 4 link link NN cord-001273-plz1ja2e 256 5 between between IN cord-001273-plz1ja2e 256 6 these these DT cord-001273-plz1ja2e 256 7 effectors effector NNS cord-001273-plz1ja2e 256 8 and and CC cord-001273-plz1ja2e 256 9 the the DT cord-001273-plz1ja2e 256 10 observed observed JJ cord-001273-plz1ja2e 256 11 harmful harmful JJ cord-001273-plz1ja2e 256 12 effects effect NNS cord-001273-plz1ja2e 256 13 of of IN cord-001273-plz1ja2e 256 14 type type NN cord-001273-plz1ja2e 256 15 I -PRON- PRP cord-001273-plz1ja2e 256 16 IFNs ifns VBP cord-001273-plz1ja2e 256 17 on on IN cord-001273-plz1ja2e 256 18 the the DT cord-001273-plz1ja2e 256 19 host host NN cord-001273-plz1ja2e 256 20 is be VBZ cord-001273-plz1ja2e 256 21 still still RB cord-001273-plz1ja2e 256 22 unclear unclear JJ cord-001273-plz1ja2e 256 23 . . . cord-001273-plz1ja2e 257 1 Likewise likewise RB cord-001273-plz1ja2e 257 2 , , , cord-001273-plz1ja2e 257 3 the the DT cord-001273-plz1ja2e 257 4 role role NN cord-001273-plz1ja2e 257 5 of of IN cord-001273-plz1ja2e 257 6 Of of IN cord-001273-plz1ja2e 257 7 interest interest NN cord-001273-plz1ja2e 257 8 , , , cord-001273-plz1ja2e 257 9 a a DT cord-001273-plz1ja2e 257 10 subset subset NN cord-001273-plz1ja2e 257 11 of of IN cord-001273-plz1ja2e 257 12 ISGs isg NNS cord-001273-plz1ja2e 257 13 is be VBZ cord-001273-plz1ja2e 257 14 amongst amongst IN cord-001273-plz1ja2e 257 15 the the DT cord-001273-plz1ja2e 257 16 most most RBS cord-001273-plz1ja2e 257 17 induced induce VBN cord-001273-plz1ja2e 257 18 genes gene NNS cord-001273-plz1ja2e 257 19 in in IN cord-001273-plz1ja2e 257 20 the the DT cord-001273-plz1ja2e 257 21 intestinal intestinal JJ cord-001273-plz1ja2e 257 22 tissue tissue NN cord-001273-plz1ja2e 257 23 of of IN cord-001273-plz1ja2e 257 24 gnotobiotic gnotobiotic JJ cord-001273-plz1ja2e 257 25 humanized humanized JJ cord-001273-plz1ja2e 257 26 mice mouse NNS cord-001273-plz1ja2e 257 27 infected infect VBN cord-001273-plz1ja2e 257 28 orally orally RB cord-001273-plz1ja2e 257 29 with with IN cord-001273-plz1ja2e 257 30 L. L. NNP cord-001273-plz1ja2e 257 31 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 257 32 ( ( -LRB- cord-001273-plz1ja2e 257 33 Archambaud Archambaud NNP cord-001273-plz1ja2e 257 34 et et FW cord-001273-plz1ja2e 257 35 al al NNP cord-001273-plz1ja2e 257 36 . . NNP cord-001273-plz1ja2e 257 37 , , , cord-001273-plz1ja2e 257 38 2012 2012 CD cord-001273-plz1ja2e 257 39 ) ) -RRB- cord-001273-plz1ja2e 257 40 . . . cord-001273-plz1ja2e 258 1 However however RB cord-001273-plz1ja2e 258 2 , , , cord-001273-plz1ja2e 258 3 which which WDT cord-001273-plz1ja2e 258 4 type type NN cord-001273-plz1ja2e 258 5 of of IN cord-001273-plz1ja2e 258 6 IFNs ifn NNS cord-001273-plz1ja2e 258 7 triggers trigger NNS cord-001273-plz1ja2e 258 8 this this DT cord-001273-plz1ja2e 258 9 response response NN cord-001273-plz1ja2e 258 10 and and CC cord-001273-plz1ja2e 258 11 for for IN cord-001273-plz1ja2e 258 12 which which WDT cord-001273-plz1ja2e 258 13 function function NN cord-001273-plz1ja2e 258 14 on on IN cord-001273-plz1ja2e 258 15 the the DT cord-001273-plz1ja2e 258 16 intestinal intestinal JJ cord-001273-plz1ja2e 258 17 mucosa mucosa NN cord-001273-plz1ja2e 258 18 remain remain VBP cord-001273-plz1ja2e 258 19 to to TO cord-001273-plz1ja2e 258 20 be be VB cord-001273-plz1ja2e 258 21 explored explore VBN cord-001273-plz1ja2e 258 22 . . . cord-001273-plz1ja2e 259 1 In in IN cord-001273-plz1ja2e 259 2 addition addition NN cord-001273-plz1ja2e 259 3 , , , cord-001273-plz1ja2e 259 4 IFN IFN NNP cord-001273-plz1ja2e 259 5 - - HYPH cord-001273-plz1ja2e 259 6 independent independent JJ cord-001273-plz1ja2e 259 7 pathways pathway NNS cord-001273-plz1ja2e 259 8 may may MD cord-001273-plz1ja2e 259 9 contribute contribute VB cord-001273-plz1ja2e 259 10 to to IN cord-001273-plz1ja2e 259 11 expression expression NN cord-001273-plz1ja2e 259 12 of of IN cord-001273-plz1ja2e 259 13 these these DT cord-001273-plz1ja2e 259 14 ISGs isg NNS cord-001273-plz1ja2e 259 15 . . . cord-001273-plz1ja2e 260 1 Listeria Listeria NNP cord-001273-plz1ja2e 260 2 has have VBZ cord-001273-plz1ja2e 260 3 evolved evolve VBN cord-001273-plz1ja2e 260 4 several several JJ cord-001273-plz1ja2e 260 5 mechanisms mechanism NNS cord-001273-plz1ja2e 260 6 to to TO cord-001273-plz1ja2e 260 7 avoid avoid VB cord-001273-plz1ja2e 260 8 immune immune JJ cord-001273-plz1ja2e 260 9 detection detection NN cord-001273-plz1ja2e 260 10 and and CC cord-001273-plz1ja2e 260 11 evade evade VB cord-001273-plz1ja2e 260 12 IFN IFN NNP cord-001273-plz1ja2e 260 13 responses response NNS cord-001273-plz1ja2e 260 14 . . . cord-001273-plz1ja2e 261 1 It -PRON- PRP cord-001273-plz1ja2e 261 2 has have VBZ cord-001273-plz1ja2e 261 3 been be VBN cord-001273-plz1ja2e 261 4 demonstrated demonstrate VBN cord-001273-plz1ja2e 261 5 that that IN cord-001273-plz1ja2e 261 6 deacetylation deacetylation NN cord-001273-plz1ja2e 261 7 of of IN cord-001273-plz1ja2e 261 8 Listeria Listeria NNP cord-001273-plz1ja2e 261 9 peptidoglycan peptidoglycan NN cord-001273-plz1ja2e 261 10 by by IN cord-001273-plz1ja2e 261 11 the the DT cord-001273-plz1ja2e 261 12 deacetylase deacetylase NN cord-001273-plz1ja2e 261 13 PgdA PgdA NNP cord-001273-plz1ja2e 261 14 confers confer VBZ cord-001273-plz1ja2e 261 15 resistance resistance NN cord-001273-plz1ja2e 261 16 to to TO cord-001273-plz1ja2e 261 17 host host VB cord-001273-plz1ja2e 261 18 lysozyme lysozyme NNS cord-001273-plz1ja2e 261 19 , , , cord-001273-plz1ja2e 261 20 thus thus RB cord-001273-plz1ja2e 261 21 preventing prevent VBG cord-001273-plz1ja2e 261 22 release release NN cord-001273-plz1ja2e 261 23 of of IN cord-001273-plz1ja2e 261 24 MAMPs mamp NNS cord-001273-plz1ja2e 261 25 , , , cord-001273-plz1ja2e 261 26 such such JJ cord-001273-plz1ja2e 261 27 as as IN cord-001273-plz1ja2e 261 28 DNA DNA NNP cord-001273-plz1ja2e 261 29 , , , cord-001273-plz1ja2e 261 30 RNA RNA NNP cord-001273-plz1ja2e 261 31 and and CC cord-001273-plz1ja2e 261 32 lipopeptides lipopeptides NNP cord-001273-plz1ja2e 261 33 , , , cord-001273-plz1ja2e 261 34 that that DT cord-001273-plz1ja2e 261 35 trigger trigger NN cord-001273-plz1ja2e 261 36 IFNβ IFNβ NNS cord-001273-plz1ja2e 261 37 production production NN cord-001273-plz1ja2e 262 1 ( ( -LRB- cord-001273-plz1ja2e 262 2 Boneca Boneca NNP cord-001273-plz1ja2e 262 3 et et NNP cord-001273-plz1ja2e 262 4 al al NNP cord-001273-plz1ja2e 262 5 . . NNP cord-001273-plz1ja2e 262 6 , , , cord-001273-plz1ja2e 262 7 2007 2007 CD cord-001273-plz1ja2e 262 8 ) ) -RRB- cord-001273-plz1ja2e 262 9 . . . cord-001273-plz1ja2e 263 1 Listeria Listeria NNP cord-001273-plz1ja2e 263 2 pgdA pgda POS cord-001273-plz1ja2e 263 3 mutants mutant NNS cord-001273-plz1ja2e 263 4 are be VBP cord-001273-plz1ja2e 263 5 rapidly rapidly RB cord-001273-plz1ja2e 263 6 killed kill VBN cord-001273-plz1ja2e 263 7 in in IN cord-001273-plz1ja2e 263 8 murine murine JJ cord-001273-plz1ja2e 263 9 macrophages macrophage NNS cord-001273-plz1ja2e 263 10 , , , cord-001273-plz1ja2e 263 11 which which WDT cord-001273-plz1ja2e 263 12 produce produce VBP cord-001273-plz1ja2e 263 13 lysozyme lysozyme NNS cord-001273-plz1ja2e 263 14 , , , cord-001273-plz1ja2e 263 15 and and CC cord-001273-plz1ja2e 263 16 induce induce VB cord-001273-plz1ja2e 263 17 a a DT cord-001273-plz1ja2e 263 18 strong strong JJ cord-001273-plz1ja2e 263 19 secretion secretion NN cord-001273-plz1ja2e 263 20 of of IN cord-001273-plz1ja2e 263 21 IFN IFN NNP cord-001273-plz1ja2e 263 22 - - HYPH cord-001273-plz1ja2e 263 23 β β NNP cord-001273-plz1ja2e 263 24 compared compare VBN cord-001273-plz1ja2e 263 25 to to IN cord-001273-plz1ja2e 263 26 wildtype wildtype JJ cord-001273-plz1ja2e 263 27 Listeria Listeria NNP cord-001273-plz1ja2e 263 28 . . . cord-001273-plz1ja2e 264 1 The the DT cord-001273-plz1ja2e 264 2 role role NN cord-001273-plz1ja2e 264 3 of of IN cord-001273-plz1ja2e 264 4 PgdA PgdA NNP cord-001273-plz1ja2e 264 5 is be VBZ cord-001273-plz1ja2e 264 6 not not RB cord-001273-plz1ja2e 264 7 limited limited JJ cord-001273-plz1ja2e 264 8 to to IN cord-001273-plz1ja2e 264 9 the the DT cord-001273-plz1ja2e 264 10 control control NN cord-001273-plz1ja2e 264 11 of of IN cord-001273-plz1ja2e 264 12 type type NN cord-001273-plz1ja2e 264 13 I I NNP cord-001273-plz1ja2e 264 14 - - HYPH cord-001273-plz1ja2e 264 15 IFN IFN NNP cord-001273-plz1ja2e 264 16 production production NN cord-001273-plz1ja2e 264 17 as as IN cord-001273-plz1ja2e 264 18 a a DT cord-001273-plz1ja2e 264 19 pgdA pgdA NNP cord-001273-plz1ja2e 264 20 mutant mutant JJ cord-001273-plz1ja2e 264 21 hyperinduces hyperinduce NNS cord-001273-plz1ja2e 264 22 proinflammatory proinflammatory JJ cord-001273-plz1ja2e 264 23 cytokines cytokine NNS cord-001273-plz1ja2e 264 24 as as RB cord-001273-plz1ja2e 264 25 well well RB cord-001273-plz1ja2e 264 26 . . . cord-001273-plz1ja2e 265 1 Modification modification NN cord-001273-plz1ja2e 265 2 of of IN cord-001273-plz1ja2e 265 3 peptidoglycan peptidoglycan NN cord-001273-plz1ja2e 265 4 by by IN cord-001273-plz1ja2e 265 5 PgdA PgdA NNP cord-001273-plz1ja2e 265 6 is be VBZ cord-001273-plz1ja2e 265 7 an an DT cord-001273-plz1ja2e 265 8 extremely extremely RB cord-001273-plz1ja2e 265 9 efficient efficient JJ cord-001273-plz1ja2e 265 10 mechanism mechanism NN cord-001273-plz1ja2e 265 11 of of IN cord-001273-plz1ja2e 265 12 immune immune JJ cord-001273-plz1ja2e 265 13 escape escape NN cord-001273-plz1ja2e 265 14 used use VBN cord-001273-plz1ja2e 265 15 by by IN cord-001273-plz1ja2e 265 16 Listeria Listeria NNP cord-001273-plz1ja2e 265 17 , , , cord-001273-plz1ja2e 265 18 which which WDT cord-001273-plz1ja2e 265 19 correlates correlate VBZ cord-001273-plz1ja2e 265 20 with with IN cord-001273-plz1ja2e 265 21 its -PRON- PRP$ cord-001273-plz1ja2e 265 22 critical critical JJ cord-001273-plz1ja2e 265 23 role role NN cord-001273-plz1ja2e 265 24 in in IN cord-001273-plz1ja2e 265 25 virulence virulence NN cord-001273-plz1ja2e 265 26 . . . cord-001273-plz1ja2e 266 1 Remarkably remarkably RB cord-001273-plz1ja2e 266 2 , , , cord-001273-plz1ja2e 266 3 Listeria Listeria NNP cord-001273-plz1ja2e 266 4 has have VBZ cord-001273-plz1ja2e 266 5 evolved evolve VBN cord-001273-plz1ja2e 266 6 a a DT cord-001273-plz1ja2e 266 7 sophisticated sophisticated JJ cord-001273-plz1ja2e 266 8 strategy strategy NN cord-001273-plz1ja2e 266 9 to to TO cord-001273-plz1ja2e 266 10 modulate modulate VB cord-001273-plz1ja2e 266 11 , , , cord-001273-plz1ja2e 266 12 either either CC cord-001273-plz1ja2e 266 13 negatively negatively RB cord-001273-plz1ja2e 266 14 or or CC cord-001273-plz1ja2e 266 15 positively positively RB cord-001273-plz1ja2e 266 16 , , , cord-001273-plz1ja2e 266 17 the the DT cord-001273-plz1ja2e 266 18 expression expression NN cord-001273-plz1ja2e 266 19 of of IN cord-001273-plz1ja2e 266 20 ISGs isg NNS cord-001273-plz1ja2e 266 21 in in IN cord-001273-plz1ja2e 266 22 epithelial epithelial JJ cord-001273-plz1ja2e 266 23 cells cell NNS cord-001273-plz1ja2e 266 24 , , , cord-001273-plz1ja2e 266 25 by by IN cord-001273-plz1ja2e 266 26 targeting target VBG cord-001273-plz1ja2e 266 27 a a DT cord-001273-plz1ja2e 266 28 chromatin chromatin NN cord-001273-plz1ja2e 266 29 - - HYPH cord-001273-plz1ja2e 266 30 repressive repressive JJ cord-001273-plz1ja2e 266 31 complex complex NN cord-001273-plz1ja2e 266 32 , , , cord-001273-plz1ja2e 266 33 BAHD1 bahd1 XX cord-001273-plz1ja2e 267 1 ( ( -LRB- cord-001273-plz1ja2e 267 2 Bierne Bierne NNP cord-001273-plz1ja2e 267 3 et et NNP cord-001273-plz1ja2e 267 4 al al NNP cord-001273-plz1ja2e 267 5 . . . cord-001273-plz1ja2e 268 1 , , , cord-001273-plz1ja2e 268 2 2009 2009 CD cord-001273-plz1ja2e 268 3 ; ; : cord-001273-plz1ja2e 268 4 Lebreton Lebreton NNP cord-001273-plz1ja2e 268 5 et et NNP cord-001273-plz1ja2e 268 6 al al NNP cord-001273-plz1ja2e 268 7 . . NNP cord-001273-plz1ja2e 268 8 , , , cord-001273-plz1ja2e 269 1 2011 2011 CD cord-001273-plz1ja2e 270 1 Lebreton Lebreton NNP cord-001273-plz1ja2e 270 2 et et FW cord-001273-plz1ja2e 270 3 al al NNP cord-001273-plz1ja2e 270 4 . . NNP cord-001273-plz1ja2e 270 5 , , , cord-001273-plz1ja2e 270 6 , , , cord-001273-plz1ja2e 270 7 2012 2012 CD cord-001273-plz1ja2e 270 8 . . . cord-001273-plz1ja2e 271 1 Indeed indeed RB cord-001273-plz1ja2e 271 2 , , , cord-001273-plz1ja2e 271 3 Listeria Listeria NNP cord-001273-plz1ja2e 271 4 infection infection NN cord-001273-plz1ja2e 271 5 promotes promote VBZ cord-001273-plz1ja2e 271 6 , , , cord-001273-plz1ja2e 271 7 albeit albeit IN cord-001273-plz1ja2e 271 8 via via IN cord-001273-plz1ja2e 271 9 an an DT cord-001273-plz1ja2e 271 10 unknown unknown JJ cord-001273-plz1ja2e 271 11 mechanism mechanism NN cord-001273-plz1ja2e 271 12 , , , cord-001273-plz1ja2e 271 13 the the DT cord-001273-plz1ja2e 271 14 targeting targeting NN cord-001273-plz1ja2e 271 15 of of IN cord-001273-plz1ja2e 271 16 BAHD1 BAHD1 NNS cord-001273-plz1ja2e 271 17 at at IN cord-001273-plz1ja2e 271 18 the the DT cord-001273-plz1ja2e 271 19 promoter promoter NN cord-001273-plz1ja2e 271 20 of of IN cord-001273-plz1ja2e 271 21 a a DT cord-001273-plz1ja2e 271 22 set set NN cord-001273-plz1ja2e 271 23 of of IN cord-001273-plz1ja2e 271 24 ISGs isg NNS cord-001273-plz1ja2e 271 25 , , , cord-001273-plz1ja2e 271 26 thereby thereby RB cord-001273-plz1ja2e 271 27 downregulating downregulate VBG cord-001273-plz1ja2e 271 28 type type NN cord-001273-plz1ja2e 271 29 I I NNP cord-001273-plz1ja2e 271 30 - - HYPH cord-001273-plz1ja2e 271 31 and and CC cord-001273-plz1ja2e 271 32 type type NN cord-001273-plz1ja2e 271 33 III III NNP cord-001273-plz1ja2e 271 34 - - HYPH cord-001273-plz1ja2e 271 35 IFN IFN NNP cord-001273-plz1ja2e 271 36 responses response NNS cord-001273-plz1ja2e 271 37 . . . cord-001273-plz1ja2e 272 1 On on IN cord-001273-plz1ja2e 272 2 the the DT cord-001273-plz1ja2e 272 3 other other JJ cord-001273-plz1ja2e 272 4 hand hand NN cord-001273-plz1ja2e 272 5 , , , cord-001273-plz1ja2e 272 6 Listeria Listeria NNP cord-001273-plz1ja2e 272 7 can can MD cord-001273-plz1ja2e 272 8 produce produce VB cord-001273-plz1ja2e 272 9 a a DT cord-001273-plz1ja2e 272 10 nucleomodulin nucleomodulin NN cord-001273-plz1ja2e 272 11 , , , cord-001273-plz1ja2e 272 12 LntA LntA NNP cord-001273-plz1ja2e 272 13 , , , cord-001273-plz1ja2e 272 14 which which WDT cord-001273-plz1ja2e 272 15 when when WRB cord-001273-plz1ja2e 272 16 secreted secrete VBN cord-001273-plz1ja2e 272 17 by by IN cord-001273-plz1ja2e 272 18 intracellular intracellular JJ cord-001273-plz1ja2e 272 19 bacteria bacteria NNS cord-001273-plz1ja2e 272 20 , , , cord-001273-plz1ja2e 272 21 enters enter VBZ cord-001273-plz1ja2e 272 22 the the DT cord-001273-plz1ja2e 272 23 nucleus nucleus NN cord-001273-plz1ja2e 272 24 of of IN cord-001273-plz1ja2e 272 25 infected infected JJ cord-001273-plz1ja2e 272 26 cells cell NNS cord-001273-plz1ja2e 272 27 , , , cord-001273-plz1ja2e 272 28 binds bind VBZ cord-001273-plz1ja2e 272 29 BAHD1 BAHD1 NNS cord-001273-plz1ja2e 272 30 and and CC cord-001273-plz1ja2e 272 31 inhibits inhibit VBZ cord-001273-plz1ja2e 272 32 its -PRON- PRP$ cord-001273-plz1ja2e 272 33 function function NN cord-001273-plz1ja2e 273 1 ( ( -LRB- cord-001273-plz1ja2e 273 2 Lebreton Lebreton NNP cord-001273-plz1ja2e 273 3 et et FW cord-001273-plz1ja2e 273 4 al al NNP cord-001273-plz1ja2e 273 5 . . . cord-001273-plz1ja2e 274 1 , , , cord-001273-plz1ja2e 274 2 , , , cord-001273-plz1ja2e 274 3 2014 2014 CD cord-001273-plz1ja2e 274 4 . . . cord-001273-plz1ja2e 275 1 Thus thus RB cord-001273-plz1ja2e 275 2 , , , cord-001273-plz1ja2e 275 3 LntA LntA NNP cord-001273-plz1ja2e 275 4 stimulates stimulate VBZ cord-001273-plz1ja2e 275 5 IFN IFN NNP cord-001273-plz1ja2e 275 6 responses response NNS cord-001273-plz1ja2e 275 7 . . . cord-001273-plz1ja2e 276 1 Consistent consistent JJ cord-001273-plz1ja2e 276 2 with with IN cord-001273-plz1ja2e 276 3 the the DT cord-001273-plz1ja2e 276 4 presence presence NN cord-001273-plz1ja2e 276 5 of of IN cord-001273-plz1ja2e 276 6 HDAC1/2 HDAC1/2 NNP cord-001273-plz1ja2e 276 7 in in IN cord-001273-plz1ja2e 276 8 the the DT cord-001273-plz1ja2e 276 9 BAHD1-associated BAHD1-associated NNP cord-001273-plz1ja2e 276 10 complex complex NN cord-001273-plz1ja2e 276 11 , , , cord-001273-plz1ja2e 276 12 the the DT cord-001273-plz1ja2e 276 13 level level NN cord-001273-plz1ja2e 276 14 of of IN cord-001273-plz1ja2e 276 15 acetylation acetylation NN cord-001273-plz1ja2e 276 16 of of IN cord-001273-plz1ja2e 276 17 lysine lysine NN cord-001273-plz1ja2e 276 18 9 9 CD cord-001273-plz1ja2e 276 19 on on IN cord-001273-plz1ja2e 276 20 histone histone NN cord-001273-plz1ja2e 276 21 H3 H3 NNP cord-001273-plz1ja2e 276 22 , , , cord-001273-plz1ja2e 276 23 which which WDT cord-001273-plz1ja2e 276 24 is be VBZ cord-001273-plz1ja2e 276 25 a a DT cord-001273-plz1ja2e 276 26 mark mark NN cord-001273-plz1ja2e 276 27 of of IN cord-001273-plz1ja2e 276 28 active active JJ cord-001273-plz1ja2e 276 29 chromatin chromatin NN cord-001273-plz1ja2e 276 30 , , , cord-001273-plz1ja2e 276 31 increases increase NNS cord-001273-plz1ja2e 276 32 at at IN cord-001273-plz1ja2e 276 33 the the DT cord-001273-plz1ja2e 276 34 promoters promoter NNS cord-001273-plz1ja2e 276 35 of of IN cord-001273-plz1ja2e 276 36 ISGs ISGs NNPS cord-001273-plz1ja2e 276 37 in in IN cord-001273-plz1ja2e 276 38 the the DT cord-001273-plz1ja2e 276 39 presence presence NN cord-001273-plz1ja2e 276 40 of of IN cord-001273-plz1ja2e 276 41 LntA. LntA. NNP cord-001273-plz1ja2e 277 1 When when WRB cord-001273-plz1ja2e 277 2 , , , cord-001273-plz1ja2e 277 3 in in IN cord-001273-plz1ja2e 277 4 which which WDT cord-001273-plz1ja2e 277 5 host host NN cord-001273-plz1ja2e 277 6 conditions condition NNS cord-001273-plz1ja2e 277 7 , , , cord-001273-plz1ja2e 277 8 and and CC cord-001273-plz1ja2e 277 9 how how WRB cord-001273-plz1ja2e 277 10 LntA LntA NNP cord-001273-plz1ja2e 277 11 targets target VBZ cord-001273-plz1ja2e 277 12 BAHD1 BAHD1 NNS cord-001273-plz1ja2e 277 13 specifically specifically RB cord-001273-plz1ja2e 277 14 at at IN cord-001273-plz1ja2e 277 15 ISGs ISGs NNP cord-001273-plz1ja2e 277 16 remains remain VBZ cord-001273-plz1ja2e 277 17 an an DT cord-001273-plz1ja2e 277 18 open open JJ cord-001273-plz1ja2e 277 19 question question NN cord-001273-plz1ja2e 277 20 . . . cord-001273-plz1ja2e 278 1 The the DT cord-001273-plz1ja2e 278 2 LntA LntA NNP cord-001273-plz1ja2e 278 3 - - HYPH cord-001273-plz1ja2e 278 4 mediated mediate VBN cord-001273-plz1ja2e 278 5 stimulation stimulation NN cord-001273-plz1ja2e 278 6 of of IN cord-001273-plz1ja2e 278 7 type type NN cord-001273-plz1ja2e 278 8 III III NNP cord-001273-plz1ja2e 278 9 - - HYPH cord-001273-plz1ja2e 278 10 IFN IFN NNP cord-001273-plz1ja2e 278 11 responses response NNS cord-001273-plz1ja2e 278 12 might may MD cord-001273-plz1ja2e 278 13 support support VB cord-001273-plz1ja2e 278 14 localized localized JJ cord-001273-plz1ja2e 278 15 pro pro JJ cord-001273-plz1ja2e 278 16 - - JJ cord-001273-plz1ja2e 278 17 bacterial bacterial JJ cord-001273-plz1ja2e 278 18 conditions condition NNS cord-001273-plz1ja2e 278 19 , , , cord-001273-plz1ja2e 278 20 as as IN cord-001273-plz1ja2e 278 21 was be VBD cord-001273-plz1ja2e 278 22 proposed propose VBN cord-001273-plz1ja2e 278 23 for for IN cord-001273-plz1ja2e 278 24 IFN IFN NNP cord-001273-plz1ja2e 278 25 - - HYPH cord-001273-plz1ja2e 278 26 I -PRON- PRP cord-001273-plz1ja2e 278 27 responses response NNS cord-001273-plz1ja2e 278 28 . . . cord-001273-plz1ja2e 279 1 We -PRON- PRP cord-001273-plz1ja2e 279 2 have have VBP cord-001273-plz1ja2e 279 3 an an DT cord-001273-plz1ja2e 279 4 extensive extensive JJ cord-001273-plz1ja2e 279 5 knowledge knowledge NN cord-001273-plz1ja2e 279 6 of of IN cord-001273-plz1ja2e 279 7 the the DT cord-001273-plz1ja2e 279 8 molecular molecular JJ cord-001273-plz1ja2e 279 9 and and CC cord-001273-plz1ja2e 279 10 cellular cellular JJ cord-001273-plz1ja2e 279 11 mechanisms mechanism NNS cord-001273-plz1ja2e 279 12 involved involve VBN cord-001273-plz1ja2e 279 13 in in IN cord-001273-plz1ja2e 279 14 Listeria Listeria NNP cord-001273-plz1ja2e 279 15 - - HYPH cord-001273-plz1ja2e 279 16 host host NN cord-001273-plz1ja2e 279 17 interactions interaction NNS cord-001273-plz1ja2e 279 18 . . . cord-001273-plz1ja2e 280 1 Yet yet RB cord-001273-plz1ja2e 280 2 , , , cord-001273-plz1ja2e 280 3 our -PRON- PRP$ cord-001273-plz1ja2e 280 4 understanding understanding NN cord-001273-plz1ja2e 280 5 of of IN cord-001273-plz1ja2e 280 6 the the DT cord-001273-plz1ja2e 280 7 immune immune JJ cord-001273-plz1ja2e 280 8 response response NN cord-001273-plz1ja2e 280 9 to to IN cord-001273-plz1ja2e 280 10 Listeria Listeria NNP cord-001273-plz1ja2e 280 11 , , , cord-001273-plz1ja2e 280 12 and and CC cord-001273-plz1ja2e 280 13 more more JJR cord-001273-plz1ja2e 280 14 specifically specifically RB cord-001273-plz1ja2e 280 15 the the DT cord-001273-plz1ja2e 280 16 role role NN cord-001273-plz1ja2e 280 17 IFNs ifn NNS cord-001273-plz1ja2e 280 18 and and CC cord-001273-plz1ja2e 280 19 of of IN cord-001273-plz1ja2e 280 20 their -PRON- PRP$ cord-001273-plz1ja2e 280 21 downstream downstream JJ cord-001273-plz1ja2e 280 22 effectors effector NNS cord-001273-plz1ja2e 280 23 , , , cord-001273-plz1ja2e 280 24 is be VBZ cord-001273-plz1ja2e 280 25 far far RB cord-001273-plz1ja2e 280 26 from from IN cord-001273-plz1ja2e 280 27 complete complete JJ cord-001273-plz1ja2e 280 28 and and CC cord-001273-plz1ja2e 280 29 often often RB cord-001273-plz1ja2e 280 30 relies rely VBZ cord-001273-plz1ja2e 280 31 on on IN cord-001273-plz1ja2e 280 32 studies study NNS cord-001273-plz1ja2e 280 33 performed perform VBN cord-001273-plz1ja2e 280 34 in in IN cord-001273-plz1ja2e 280 35 cultured cultured JJ cord-001273-plz1ja2e 280 36 cells cell NNS cord-001273-plz1ja2e 280 37 or or CC cord-001273-plz1ja2e 280 38 in in IN cord-001273-plz1ja2e 280 39 mice mouse NNS cord-001273-plz1ja2e 280 40 . . . cord-001273-plz1ja2e 281 1 However however RB cord-001273-plz1ja2e 281 2 , , , cord-001273-plz1ja2e 281 3 murine murine JJ cord-001273-plz1ja2e 281 4 and and CC cord-001273-plz1ja2e 281 5 human human JJ cord-001273-plz1ja2e 281 6 listeriosis listeriosis NN cord-001273-plz1ja2e 281 7 differ differ VBP cord-001273-plz1ja2e 281 8 in in IN cord-001273-plz1ja2e 281 9 many many JJ cord-001273-plz1ja2e 281 10 aspects aspect NNS cord-001273-plz1ja2e 281 11 ( ( -LRB- cord-001273-plz1ja2e 281 12 Lecuit Lecuit NNP cord-001273-plz1ja2e 281 13 , , , cord-001273-plz1ja2e 281 14 2007 2007 CD cord-001273-plz1ja2e 281 15 ; ; . cord-001273-plz1ja2e 282 1 Hoelzer Hoelzer NNP cord-001273-plz1ja2e 282 2 et et NNP cord-001273-plz1ja2e 282 3 al al NNP cord-001273-plz1ja2e 282 4 . . NNP cord-001273-plz1ja2e 282 5 , , , cord-001273-plz1ja2e 282 6 2012 2012 CD cord-001273-plz1ja2e 282 7 ) ) -RRB- cord-001273-plz1ja2e 282 8 . . . cord-001273-plz1ja2e 283 1 For for IN cord-001273-plz1ja2e 283 2 instance instance NN cord-001273-plz1ja2e 283 3 , , , cord-001273-plz1ja2e 283 4 E e NN cord-001273-plz1ja2e 283 5 - - NN cord-001273-plz1ja2e 283 6 cadherin cadherin NN cord-001273-plz1ja2e 283 7 , , , cord-001273-plz1ja2e 283 8 the the DT cord-001273-plz1ja2e 283 9 major major JJ cord-001273-plz1ja2e 283 10 receptor receptor NN cord-001273-plz1ja2e 283 11 for for IN cord-001273-plz1ja2e 283 12 Listeria Listeria NNP cord-001273-plz1ja2e 283 13 in in IN cord-001273-plz1ja2e 283 14 epithelial epithelial JJ cord-001273-plz1ja2e 283 15 cells cell NNS cord-001273-plz1ja2e 283 16 , , , cord-001273-plz1ja2e 283 17 is be VBZ cord-001273-plz1ja2e 283 18 not not RB cord-001273-plz1ja2e 283 19 functional functional JJ cord-001273-plz1ja2e 283 20 for for IN cord-001273-plz1ja2e 283 21 Listeria Listeria NNP cord-001273-plz1ja2e 283 22 uptake uptake NN cord-001273-plz1ja2e 283 23 in in IN cord-001273-plz1ja2e 283 24 the the DT cord-001273-plz1ja2e 283 25 mouse mouse NN cord-001273-plz1ja2e 283 26 . . . cord-001273-plz1ja2e 284 1 Thus thus RB cord-001273-plz1ja2e 284 2 , , , cord-001273-plz1ja2e 284 3 the the DT cord-001273-plz1ja2e 284 4 route route NN cord-001273-plz1ja2e 284 5 of of IN cord-001273-plz1ja2e 284 6 entry entry NN cord-001273-plz1ja2e 284 7 of of IN cord-001273-plz1ja2e 284 8 Listeria Listeria NNP cord-001273-plz1ja2e 284 9 is be VBZ cord-001273-plz1ja2e 284 10 not not RB cord-001273-plz1ja2e 284 11 strictly strictly RB cord-001273-plz1ja2e 284 12 the the DT cord-001273-plz1ja2e 284 13 same same JJ cord-001273-plz1ja2e 284 14 in in IN cord-001273-plz1ja2e 284 15 mice mouse NNS cord-001273-plz1ja2e 284 16 and and CC cord-001273-plz1ja2e 284 17 humans human NNS cord-001273-plz1ja2e 284 18 . . . cord-001273-plz1ja2e 285 1 Moreover moreover RB cord-001273-plz1ja2e 285 2 , , , cord-001273-plz1ja2e 285 3 ISGs ISGs NNP cord-001273-plz1ja2e 285 4 induced induce VBN cord-001273-plz1ja2e 285 5 in in IN cord-001273-plz1ja2e 285 6 response response NN cord-001273-plz1ja2e 285 7 to to IN cord-001273-plz1ja2e 285 8 infection infection NN cord-001273-plz1ja2e 285 9 are be VBP cord-001273-plz1ja2e 285 10 not not RB cord-001273-plz1ja2e 285 11 identical identical JJ cord-001273-plz1ja2e 285 12 in in IN cord-001273-plz1ja2e 285 13 mice mouse NNS cord-001273-plz1ja2e 285 14 and and CC cord-001273-plz1ja2e 285 15 humans human NNS cord-001273-plz1ja2e 285 16 . . . cord-001273-plz1ja2e 286 1 Additionally additionally RB cord-001273-plz1ja2e 286 2 , , , cord-001273-plz1ja2e 286 3 murine murine JJ cord-001273-plz1ja2e 286 4 hepatocytes hepatocyte NNS cord-001273-plz1ja2e 286 5 do do VBP cord-001273-plz1ja2e 286 6 not not RB cord-001273-plz1ja2e 286 7 respond respond VB cord-001273-plz1ja2e 286 8 to to TO cord-001273-plz1ja2e 286 9 type type VB cord-001273-plz1ja2e 286 10 III III NNP cord-001273-plz1ja2e 286 11 - - HYPH cord-001273-plz1ja2e 286 12 IFNs IFNs NNP cord-001273-plz1ja2e 286 13 ( ( -LRB- cord-001273-plz1ja2e 286 14 Hermant Hermant NNP cord-001273-plz1ja2e 286 15 et et NNP cord-001273-plz1ja2e 286 16 al al NNP cord-001273-plz1ja2e 286 17 . . NNP cord-001273-plz1ja2e 286 18 , , , cord-001273-plz1ja2e 286 19 2014 2014 CD cord-001273-plz1ja2e 286 20 ) ) -RRB- cord-001273-plz1ja2e 286 21 , , , cord-001273-plz1ja2e 286 22 precluding preclude VBG cord-001273-plz1ja2e 286 23 the the DT cord-001273-plz1ja2e 286 24 study study NN cord-001273-plz1ja2e 286 25 of of IN cord-001273-plz1ja2e 286 26 these these DT cord-001273-plz1ja2e 286 27 IFNs ifn NNS cord-001273-plz1ja2e 286 28 during during IN cord-001273-plz1ja2e 286 29 infection infection NN cord-001273-plz1ja2e 286 30 by by IN cord-001273-plz1ja2e 286 31 human human JJ cord-001273-plz1ja2e 286 32 hepatotropic hepatotropic JJ cord-001273-plz1ja2e 286 33 pathogens pathogen NNS cord-001273-plz1ja2e 286 34 , , , cord-001273-plz1ja2e 286 35 such such JJ cord-001273-plz1ja2e 286 36 as as IN cord-001273-plz1ja2e 286 37 L. L. NNP cord-001273-plz1ja2e 286 38 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 286 39 . . . cord-001273-plz1ja2e 287 1 Altogether altogether RB cord-001273-plz1ja2e 287 2 , , , cord-001273-plz1ja2e 287 3 species species NN cord-001273-plz1ja2e 287 4 - - HYPH cord-001273-plz1ja2e 287 5 specific specific JJ cord-001273-plz1ja2e 287 6 differences difference NNS cord-001273-plz1ja2e 287 7 provide provide VBP cord-001273-plz1ja2e 287 8 limits limit NNS cord-001273-plz1ja2e 287 9 to to IN cord-001273-plz1ja2e 287 10 the the DT cord-001273-plz1ja2e 287 11 use use NN cord-001273-plz1ja2e 287 12 of of IN cord-001273-plz1ja2e 287 13 mouse mouse NN cord-001273-plz1ja2e 287 14 models model NNS cord-001273-plz1ja2e 287 15 in in IN cord-001273-plz1ja2e 287 16 characterizing characterize VBG cord-001273-plz1ja2e 287 17 IFN IFN NNP cord-001273-plz1ja2e 287 18 pathways pathway NNS cord-001273-plz1ja2e 287 19 engaged engage VBN cord-001273-plz1ja2e 287 20 during during IN cord-001273-plz1ja2e 287 21 Listeria Listeria NNP cord-001273-plz1ja2e 287 22 infection infection NN cord-001273-plz1ja2e 287 23 in in IN cord-001273-plz1ja2e 287 24 humans human NNS cord-001273-plz1ja2e 287 25 , , , cord-001273-plz1ja2e 287 26 especially especially RB cord-001273-plz1ja2e 287 27 in in IN cord-001273-plz1ja2e 287 28 key key JJ cord-001273-plz1ja2e 287 29 epithelial epithelial JJ cord-001273-plz1ja2e 287 30 organs organ NNS cord-001273-plz1ja2e 287 31 such such JJ cord-001273-plz1ja2e 287 32 as as IN cord-001273-plz1ja2e 287 33 the the DT cord-001273-plz1ja2e 287 34 gut gut NN cord-001273-plz1ja2e 287 35 , , , cord-001273-plz1ja2e 287 36 liver liver NN cord-001273-plz1ja2e 287 37 and and CC cord-001273-plz1ja2e 287 38 placenta placenta NN cord-001273-plz1ja2e 287 39 . . . cord-001273-plz1ja2e 288 1 It -PRON- PRP cord-001273-plz1ja2e 288 2 will will MD cord-001273-plz1ja2e 288 3 be be VB cord-001273-plz1ja2e 288 4 important important JJ cord-001273-plz1ja2e 288 5 to to TO cord-001273-plz1ja2e 288 6 perform perform VB cord-001273-plz1ja2e 288 7 future future JJ cord-001273-plz1ja2e 288 8 studies study NNS cord-001273-plz1ja2e 288 9 using use VBG cord-001273-plz1ja2e 288 10 adapted adapt VBN cord-001273-plz1ja2e 288 11 animal animal NN cord-001273-plz1ja2e 288 12 models model NNS cord-001273-plz1ja2e 288 13 , , , cord-001273-plz1ja2e 288 14 such such JJ cord-001273-plz1ja2e 288 15 as as IN cord-001273-plz1ja2e 288 16 humanized humanized JJ cord-001273-plz1ja2e 288 17 mice mouse NNS cord-001273-plz1ja2e 288 18 permissive permissive JJ cord-001273-plz1ja2e 288 19 to to IN cord-001273-plz1ja2e 288 20 oral oral JJ cord-001273-plz1ja2e 288 21 infection infection NN cord-001273-plz1ja2e 288 22 or or CC cord-001273-plz1ja2e 288 23 transgenic transgenic JJ cord-001273-plz1ja2e 288 24 mice mouse NNS cord-001273-plz1ja2e 288 25 with with IN cord-001273-plz1ja2e 288 26 human human JJ cord-001273-plz1ja2e 288 27 xenografts xenograft NNS cord-001273-plz1ja2e 288 28 ( ( -LRB- cord-001273-plz1ja2e 288 29 Walters Walters NNP cord-001273-plz1ja2e 288 30 et et NNP cord-001273-plz1ja2e 288 31 al al NNP cord-001273-plz1ja2e 288 32 . . NNP cord-001273-plz1ja2e 288 33 , , , cord-001273-plz1ja2e 288 34 2006 2006 CD cord-001273-plz1ja2e 288 35 ) ) -RRB- cord-001273-plz1ja2e 288 36 , , , cord-001273-plz1ja2e 288 37 since since IN cord-001273-plz1ja2e 288 38 the the DT cord-001273-plz1ja2e 288 39 effect effect NN cord-001273-plz1ja2e 288 40 of of IN cord-001273-plz1ja2e 288 41 type type NN cord-001273-plz1ja2e 288 42 I I NNP cord-001273-plz1ja2e 288 43 - - HYPH cord-001273-plz1ja2e 288 44 IFN IFN NNP cord-001273-plz1ja2e 288 45 on on IN cord-001273-plz1ja2e 288 46 Listeria Listeria NNP cord-001273-plz1ja2e 288 47 infection infection NN cord-001273-plz1ja2e 288 48 depends depend VBZ cord-001273-plz1ja2e 288 49 on on IN cord-001273-plz1ja2e 288 50 the the DT cord-001273-plz1ja2e 288 51 route route NN cord-001273-plz1ja2e 288 52 and and CC cord-001273-plz1ja2e 288 53 time time NN cord-001273-plz1ja2e 288 54 of of IN cord-001273-plz1ja2e 288 55 infection infection NN cord-001273-plz1ja2e 289 1 ( ( -LRB- cord-001273-plz1ja2e 289 2 Pontiroli Pontiroli NNP cord-001273-plz1ja2e 289 3 et et NNP cord-001273-plz1ja2e 289 4 al al NNP cord-001273-plz1ja2e 289 5 . . NNP cord-001273-plz1ja2e 289 6 , , , cord-001273-plz1ja2e 289 7 2012 2012 CD cord-001273-plz1ja2e 289 8 ; ; : cord-001273-plz1ja2e 289 9 Kernbauer Kernbauer NNP cord-001273-plz1ja2e 289 10 et et NNP cord-001273-plz1ja2e 289 11 al al NNP cord-001273-plz1ja2e 289 12 . . NNP cord-001273-plz1ja2e 289 13 , , , cord-001273-plz1ja2e 289 14 2013 2013 CD cord-001273-plz1ja2e 289 15 ) ) -RRB- cord-001273-plz1ja2e 289 16 and and CC cord-001273-plz1ja2e 290 1 type type NNP cord-001273-plz1ja2e 290 2 III III NNP cord-001273-plz1ja2e 290 3 - - HYPH cord-001273-plz1ja2e 290 4 IFN IFN NNP cord-001273-plz1ja2e 290 5 requires require VBZ cord-001273-plz1ja2e 290 6 bacterial bacterial JJ cord-001273-plz1ja2e 290 7 interaction interaction NN cord-001273-plz1ja2e 290 8 with with IN cord-001273-plz1ja2e 290 9 epithelia epithelium NNS cord-001273-plz1ja2e 290 10 . . . cord-001273-plz1ja2e 291 1 Finally finally RB cord-001273-plz1ja2e 291 2 , , , cord-001273-plz1ja2e 291 3 numerous numerous JJ cord-001273-plz1ja2e 291 4 ISGs isg NNS cord-001273-plz1ja2e 291 5 are be VBP cord-001273-plz1ja2e 291 6 induced induce VBN cord-001273-plz1ja2e 291 7 upon upon IN cord-001273-plz1ja2e 291 8 Listeria Listeria NNP cord-001273-plz1ja2e 291 9 infection infection NN cord-001273-plz1ja2e 291 10 in in IN cord-001273-plz1ja2e 291 11 vitro vitro FW cord-001273-plz1ja2e 291 12 , , , cord-001273-plz1ja2e 291 13 but but CC cord-001273-plz1ja2e 291 14 the the DT cord-001273-plz1ja2e 291 15 relevant relevant JJ cord-001273-plz1ja2e 291 16 ISGs isg NNS cord-001273-plz1ja2e 291 17 and and CC cord-001273-plz1ja2e 291 18 their -PRON- PRP$ cord-001273-plz1ja2e 291 19 cellular cellular JJ cord-001273-plz1ja2e 291 20 functions function NNS cord-001273-plz1ja2e 291 21 remain remain VBP cord-001273-plz1ja2e 291 22 to to TO cord-001273-plz1ja2e 291 23 be be VB cord-001273-plz1ja2e 291 24 identified identify VBN cord-001273-plz1ja2e 291 25 . . . cord-001273-plz1ja2e 292 1 Validation validation NN cord-001273-plz1ja2e 292 2 of of IN cord-001273-plz1ja2e 292 3 ISGs isg NNS cord-001273-plz1ja2e 292 4 identified identify VBN cord-001273-plz1ja2e 292 5 in in IN cord-001273-plz1ja2e 292 6 cultured cultured JJ cord-001273-plz1ja2e 292 7 cells cell NNS cord-001273-plz1ja2e 292 8 in in IN cord-001273-plz1ja2e 292 9 adequate adequate NN cord-001273-plz1ja2e 292 10 in in IN cord-001273-plz1ja2e 292 11 vivo vivo NN cord-001273-plz1ja2e 292 12 models model NNS cord-001273-plz1ja2e 292 13 or or CC cord-001273-plz1ja2e 292 14 deduced deduce VBN cord-001273-plz1ja2e 292 15 from from IN cord-001273-plz1ja2e 292 16 analyses analysis NNS cord-001273-plz1ja2e 292 17 of of IN cord-001273-plz1ja2e 292 18 patient patient NN cord-001273-plz1ja2e 292 19 samples sample NNS cord-001273-plz1ja2e 292 20 , , , cord-001273-plz1ja2e 292 21 will will MD cord-001273-plz1ja2e 292 22 be be VB cord-001273-plz1ja2e 292 23 required require VBN cord-001273-plz1ja2e 292 24 to to TO cord-001273-plz1ja2e 292 25 address address VB cord-001273-plz1ja2e 292 26 the the DT cord-001273-plz1ja2e 292 27 complex complex JJ cord-001273-plz1ja2e 292 28 role role NN cord-001273-plz1ja2e 292 29 of of IN cord-001273-plz1ja2e 292 30 IFNs ifn NNS cord-001273-plz1ja2e 292 31 and and CC cord-001273-plz1ja2e 292 32 bacterial bacterial JJ cord-001273-plz1ja2e 292 33 subversion subversion NN cord-001273-plz1ja2e 292 34 strategies strategy NNS cord-001273-plz1ja2e 292 35 and and CC cord-001273-plz1ja2e 292 36 provide provide VB cord-001273-plz1ja2e 292 37 new new JJ cord-001273-plz1ja2e 292 38 insights insight NNS cord-001273-plz1ja2e 292 39 into into IN cord-001273-plz1ja2e 292 40 Listeria Listeria NNP cord-001273-plz1ja2e 292 41 pathogenesis pathogenesis NN cord-001273-plz1ja2e 292 42 . . . cord-001273-plz1ja2e 293 1 RIG rig NN cord-001273-plz1ja2e 293 2 - - : cord-001273-plz1ja2e 293 3 I -PRON- PRP cord-001273-plz1ja2e 293 4 detects detect VBZ cord-001273-plz1ja2e 293 5 infection infection NN cord-001273-plz1ja2e 293 6 with with IN cord-001273-plz1ja2e 293 7 live live JJ cord-001273-plz1ja2e 293 8 Listeria Listeria NNP cord-001273-plz1ja2e 293 9 by by IN cord-001273-plz1ja2e 293 10 sensing sense VBG cord-001273-plz1ja2e 293 11 secreted secrete VBN cord-001273-plz1ja2e 293 12 bacterial bacterial JJ cord-001273-plz1ja2e 293 13 nucleic nucleic JJ cord-001273-plz1ja2e 293 14 acids acid NNS cord-001273-plz1ja2e 294 1 cGAS cGAS NNP cord-001273-plz1ja2e 294 2 produces produce VBZ cord-001273-plz1ja2e 294 3 a a DT cord-001273-plz1ja2e 294 4 2 2 CD cord-001273-plz1ja2e 294 5 -5 -5 CD cord-001273-plz1ja2e 294 6 -linked -linked JJ cord-001273-plz1ja2e 294 7 cyclic cyclic JJ cord-001273-plz1ja2e 294 8 dinucleotide dinucleotide NN cord-001273-plz1ja2e 294 9 second second JJ cord-001273-plz1ja2e 294 10 messenger messenger NN cord-001273-plz1ja2e 294 11 that that WDT cord-001273-plz1ja2e 294 12 activates activate VBZ cord-001273-plz1ja2e 294 13 STING STING NNP cord-001273-plz1ja2e 294 14 Impact impact NN cord-001273-plz1ja2e 294 15 of of IN cord-001273-plz1ja2e 294 16 lactobacilli lactobacillus NNS cord-001273-plz1ja2e 294 17 on on IN cord-001273-plz1ja2e 294 18 orally orally RB cord-001273-plz1ja2e 294 19 acquired acquire VBN cord-001273-plz1ja2e 294 20 listeriosis listeriosis NN cord-001273-plz1ja2e 294 21 STING sting NN cord-001273-plz1ja2e 294 22 - - HYPH cord-001273-plz1ja2e 294 23 dependent dependent JJ cord-001273-plz1ja2e 294 24 type type NN cord-001273-plz1ja2e 295 1 I -PRON- PRP cord-001273-plz1ja2e 295 2 IFN IFN NNP cord-001273-plz1ja2e 295 3 production production NN cord-001273-plz1ja2e 295 4 inhibits inhibit VBZ cord-001273-plz1ja2e 295 5 cell cell NN cord-001273-plz1ja2e 295 6 - - HYPH cord-001273-plz1ja2e 295 7 mediated mediate VBN cord-001273-plz1ja2e 295 8 immunity immunity NN cord-001273-plz1ja2e 295 9 to to IN cord-001273-plz1ja2e 295 10 Listeria Listeria NNP cord-001273-plz1ja2e 295 11 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 296 1 Both both DT cord-001273-plz1ja2e 296 2 TLR2 TLR2 NNP cord-001273-plz1ja2e 296 3 and and CC cord-001273-plz1ja2e 296 4 TRIF TRIF NNP cord-001273-plz1ja2e 296 5 contribute contribute VBP cord-001273-plz1ja2e 296 6 to to IN cord-001273-plz1ja2e 296 7 interferon interferon NN cord-001273-plz1ja2e 296 8 - - HYPH cord-001273-plz1ja2e 296 9 β β NN cord-001273-plz1ja2e 296 10 production production NN cord-001273-plz1ja2e 296 11 during during IN cord-001273-plz1ja2e 296 12 Listeria Listeria NNP cord-001273-plz1ja2e 296 13 infection infection NN cord-001273-plz1ja2e 297 1 OatA OatA NNP cord-001273-plz1ja2e 297 2 , , , cord-001273-plz1ja2e 297 3 a a DT cord-001273-plz1ja2e 297 4 peptidoglycan peptidoglycan JJ cord-001273-plz1ja2e 297 5 O o NN cord-001273-plz1ja2e 297 6 - - HYPH cord-001273-plz1ja2e 297 7 acetyltransferase acetyltransferase NN cord-001273-plz1ja2e 297 8 involved involve VBN cord-001273-plz1ja2e 297 9 in in IN cord-001273-plz1ja2e 297 10 Listeria Listeria NNP cord-001273-plz1ja2e 297 11 monocytogenes monocytogene NNS cord-001273-plz1ja2e 297 12 immune immune JJ cord-001273-plz1ja2e 297 13 escape escape NN cord-001273-plz1ja2e 297 14 , , , cord-001273-plz1ja2e 297 15 is be VBZ cord-001273-plz1ja2e 297 16 critical critical JJ cord-001273-plz1ja2e 297 17 for for IN cord-001273-plz1ja2e 297 18 virulence virulence NN cord-001273-plz1ja2e 297 19 Mice mouse NNS cord-001273-plz1ja2e 297 20 lacking lack VBG cord-001273-plz1ja2e 297 21 the the DT cord-001273-plz1ja2e 297 22 type type NN cord-001273-plz1ja2e 297 23 I -PRON- PRP cord-001273-plz1ja2e 297 24 interferon interferon VBD cord-001273-plz1ja2e 297 25 receptor receptor NN cord-001273-plz1ja2e 297 26 are be VBP cord-001273-plz1ja2e 297 27 resistant resistant JJ cord-001273-plz1ja2e 297 28 to to IN cord-001273-plz1ja2e 297 29 Listeria Listeria NNP cord-001273-plz1ja2e 297 30 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 298 1 The the DT cord-001273-plz1ja2e 298 2 IFN IFN NNP cord-001273-plz1ja2e 298 3 gamma gamma NN cord-001273-plz1ja2e 298 4 receptor receptor NN cord-001273-plz1ja2e 298 5 : : : cord-001273-plz1ja2e 299 1 a a DT cord-001273-plz1ja2e 299 2 paradigm paradigm NN cord-001273-plz1ja2e 299 3 for for IN cord-001273-plz1ja2e 299 4 cytokine cytokine NN cord-001273-plz1ja2e 299 5 receptor receptor NN cord-001273-plz1ja2e 299 6 signaling signal VBG cord-001273-plz1ja2e 299 7 Human Human NNP cord-001273-plz1ja2e 299 8 BAHD1 bahd1 XX cord-001273-plz1ja2e 299 9 promotes promote VBZ cord-001273-plz1ja2e 299 10 heterochromatic heterochromatic JJ cord-001273-plz1ja2e 299 11 gene gene NN cord-001273-plz1ja2e 299 12 silencing silence VBG cord-001273-plz1ja2e 299 13 Activation activation NN cord-001273-plz1ja2e 299 14 of of IN cord-001273-plz1ja2e 299 15 type type NN cord-001273-plz1ja2e 299 16 III iii CD cord-001273-plz1ja2e 299 17 interferon interferon NN cord-001273-plz1ja2e 299 18 genes gene NNS cord-001273-plz1ja2e 299 19 by by IN cord-001273-plz1ja2e 299 20 pathogenic pathogenic JJ cord-001273-plz1ja2e 299 21 bacteria bacteria NNS cord-001273-plz1ja2e 299 22 in in IN cord-001273-plz1ja2e 299 23 infected infected JJ cord-001273-plz1ja2e 299 24 epithelial epithelial JJ cord-001273-plz1ja2e 299 25 cells cell NNS cord-001273-plz1ja2e 299 26 and and CC cord-001273-plz1ja2e 299 27 mouse mouse NN cord-001273-plz1ja2e 299 28 placenta placenta NN cord-001273-plz1ja2e 300 1 Two two CD cord-001273-plz1ja2e 300 2 families family NNS cord-001273-plz1ja2e 300 3 of of IN cord-001273-plz1ja2e 300 4 GTPases gtpase NNS cord-001273-plz1ja2e 300 5 dominate dominate VBP cord-001273-plz1ja2e 300 6 the the DT cord-001273-plz1ja2e 300 7 complex complex JJ cord-001273-plz1ja2e 300 8 cellular cellular JJ cord-001273-plz1ja2e 300 9 response response NN cord-001273-plz1ja2e 300 10 to to IN cord-001273-plz1ja2e 300 11 IFN IFN NNP cord-001273-plz1ja2e 300 12 - - HYPH cord-001273-plz1ja2e 300 13 gamma gamma NNP cord-001273-plz1ja2e 300 14 A a DT cord-001273-plz1ja2e 300 15 critical critical JJ cord-001273-plz1ja2e 300 16 role role NN cord-001273-plz1ja2e 300 17 for for IN cord-001273-plz1ja2e 300 18 peptidoglycan peptidoglycan JJ cord-001273-plz1ja2e 300 19 N n CD cord-001273-plz1ja2e 300 20 - - HYPH cord-001273-plz1ja2e 300 21 deacetylation deacetylation NN cord-001273-plz1ja2e 300 22 in in IN cord-001273-plz1ja2e 300 23 Listeria Listeria NNP cord-001273-plz1ja2e 300 24 evasion evasion NN cord-001273-plz1ja2e 300 25 from from IN cord-001273-plz1ja2e 300 26 the the DT cord-001273-plz1ja2e 300 27 host host NN cord-001273-plz1ja2e 300 28 innate innate JJ cord-001273-plz1ja2e 300 29 immune immune JJ cord-001273-plz1ja2e 300 30 system system NN cord-001273-plz1ja2e 300 31 Multiple multiple JJ cord-001273-plz1ja2e 300 32 mechanisms mechanism NNS cord-001273-plz1ja2e 300 33 contribute contribute VBP cord-001273-plz1ja2e 300 34 to to IN cord-001273-plz1ja2e 300 35 the the DT cord-001273-plz1ja2e 300 36 robust robust JJ cord-001273-plz1ja2e 300 37 rapid rapid JJ cord-001273-plz1ja2e 300 38 gamma gamma NN cord-001273-plz1ja2e 300 39 interferon interferon NN cord-001273-plz1ja2e 300 40 response response NN cord-001273-plz1ja2e 300 41 by by IN cord-001273-plz1ja2e 300 42 CD8 CD8 NNP cord-001273-plz1ja2e 300 43 + + CC cord-001273-plz1ja2e 300 44 T T NNP cord-001273-plz1ja2e 300 45 cells cell NNS cord-001273-plz1ja2e 300 46 during during IN cord-001273-plz1ja2e 301 1 Listeria Listeria NNP cord-001273-plz1ja2e 301 2 monocytogenes monocytogene VBZ cord-001273-plz1ja2e 301 3 infection infection NN cord-001273-plz1ja2e 301 4 Type type NN cord-001273-plz1ja2e 301 5 I -PRON- PRP cord-001273-plz1ja2e 301 6 interferon interferon NN cord-001273-plz1ja2e 301 7 signaling signal VBG cord-001273-plz1ja2e 301 8 regulates regulate VBZ cord-001273-plz1ja2e 301 9 the the DT cord-001273-plz1ja2e 301 10 composition composition NN cord-001273-plz1ja2e 301 11 of of IN cord-001273-plz1ja2e 301 12 inflammatory inflammatory JJ cord-001273-plz1ja2e 301 13 infiltrates infiltrate NNS cord-001273-plz1ja2e 301 14 upon upon IN cord-001273-plz1ja2e 301 15 infection infection NN cord-001273-plz1ja2e 301 16 with with IN cord-001273-plz1ja2e 301 17 Listeria Listeria NNP cord-001273-plz1ja2e 301 18 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 301 19 Requirement Requirement NNP cord-001273-plz1ja2e 301 20 of of IN cord-001273-plz1ja2e 301 21 endogenous endogenous JJ cord-001273-plz1ja2e 301 22 interferon interferon NN cord-001273-plz1ja2e 301 23 - - HYPH cord-001273-plz1ja2e 301 24 gamma gamma NN cord-001273-plz1ja2e 301 25 production production NN cord-001273-plz1ja2e 301 26 for for IN cord-001273-plz1ja2e 301 27 resolution resolution NN cord-001273-plz1ja2e 301 28 of of IN cord-001273-plz1ja2e 301 29 Listeria Listeria NNP cord-001273-plz1ja2e 301 30 monocytogenes monocytogene NNS cord-001273-plz1ja2e 301 31 infection infection NN cord-001273-plz1ja2e 301 32 STING sting NN cord-001273-plz1ja2e 302 1 is be VBZ cord-001273-plz1ja2e 302 2 a a DT cord-001273-plz1ja2e 302 3 direct direct JJ cord-001273-plz1ja2e 302 4 innate innate JJ cord-001273-plz1ja2e 302 5 immune immune JJ cord-001273-plz1ja2e 302 6 sensor sensor NN cord-001273-plz1ja2e 302 7 of of IN cord-001273-plz1ja2e 302 8 cyclic cyclic JJ cord-001273-plz1ja2e 302 9 di di FW cord-001273-plz1ja2e 302 10 - - HYPH cord-001273-plz1ja2e 302 11 GMP GMP NNP cord-001273-plz1ja2e 303 1 The the DT cord-001273-plz1ja2e 303 2 arsenal arsenal NN cord-001273-plz1ja2e 303 3 of of IN cord-001273-plz1ja2e 303 4 virulence virulence NN cord-001273-plz1ja2e 303 5 factors factor NNS cord-001273-plz1ja2e 303 6 deployed deploy VBN cord-001273-plz1ja2e 303 7 by by IN cord-001273-plz1ja2e 303 8 Listeria Listeria NNP cord-001273-plz1ja2e 303 9 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 303 10 to to TO cord-001273-plz1ja2e 303 11 promote promote VB cord-001273-plz1ja2e 303 12 its -PRON- PRP$ cord-001273-plz1ja2e 303 13 cell cell NN cord-001273-plz1ja2e 303 14 infection infection NN cord-001273-plz1ja2e 303 15 cycle cycle NN cord-001273-plz1ja2e 303 16 Lymphocyte Lymphocyte NNP cord-001273-plz1ja2e 303 17 apoptosis apoptosis NN cord-001273-plz1ja2e 303 18 as as IN cord-001273-plz1ja2e 303 19 an an DT cord-001273-plz1ja2e 303 20 immune immune JJ cord-001273-plz1ja2e 303 21 subversion subversion NN cord-001273-plz1ja2e 303 22 strategy strategy NN cord-001273-plz1ja2e 303 23 of of IN cord-001273-plz1ja2e 303 24 microbial microbial JJ cord-001273-plz1ja2e 303 25 pathogens pathogen NNS cord-001273-plz1ja2e 303 26 Confounding confound VBG cord-001273-plz1ja2e 303 27 roles role NNS cord-001273-plz1ja2e 303 28 for for IN cord-001273-plz1ja2e 303 29 type type NN cord-001273-plz1ja2e 304 1 I -PRON- PRP cord-001273-plz1ja2e 304 2 interferons interferon NNS cord-001273-plz1ja2e 304 3 during during IN cord-001273-plz1ja2e 304 4 bacterial bacterial JJ cord-001273-plz1ja2e 304 5 and and CC cord-001273-plz1ja2e 304 6 viral viral JJ cord-001273-plz1ja2e 304 7 pathogenesis pathogenesis NN cord-001273-plz1ja2e 304 8 Type type NN cord-001273-plz1ja2e 305 1 I -PRON- PRP cord-001273-plz1ja2e 305 2 interferon interferon NN cord-001273-plz1ja2e 305 3 sensitizes sensitize VBZ cord-001273-plz1ja2e 305 4 lymphocytes lymphocyte NNS cord-001273-plz1ja2e 305 5 to to IN cord-001273-plz1ja2e 305 6 apoptosis apoptosis NN cord-001273-plz1ja2e 305 7 and and CC cord-001273-plz1ja2e 305 8 reduces reduce VBZ cord-001273-plz1ja2e 305 9 resistance resistance NN cord-001273-plz1ja2e 305 10 to to IN cord-001273-plz1ja2e 305 11 Listeria Listeria NNP cord-001273-plz1ja2e 305 12 infection infection NN cord-001273-plz1ja2e 305 13 Listeriosis Listeriosis NNP cord-001273-plz1ja2e 305 14 outbreaks outbreak NNS cord-001273-plz1ja2e 305 15 and and CC cord-001273-plz1ja2e 305 16 associated associate VBD cord-001273-plz1ja2e 305 17 food food NN cord-001273-plz1ja2e 305 18 vehicles vehicle NNS cord-001273-plz1ja2e 306 1 Listerial listerial JJ cord-001273-plz1ja2e 306 2 invasion invasion NN cord-001273-plz1ja2e 306 3 protein protein NN cord-001273-plz1ja2e 306 4 internalin internalin NNP cord-001273-plz1ja2e 306 5 B B NNP cord-001273-plz1ja2e 306 6 promotes promote VBZ cord-001273-plz1ja2e 306 7 entry entry NN cord-001273-plz1ja2e 306 8 into into IN cord-001273-plz1ja2e 306 9 ileal ileal JJ cord-001273-plz1ja2e 306 10 Peyer Peyer NNP cord-001273-plz1ja2e 306 11 's 's POS cord-001273-plz1ja2e 306 12 patches patch NNS cord-001273-plz1ja2e 306 13 in in IN cord-001273-plz1ja2e 306 14 vivo vivo NN cord-001273-plz1ja2e 306 15 Cutting cut VBG cord-001273-plz1ja2e 306 16 edge edge NN cord-001273-plz1ja2e 306 17 : : : cord-001273-plz1ja2e 306 18 IFN IFN NNP cord-001273-plz1ja2e 306 19 - - HYPH cord-001273-plz1ja2e 306 20 inducible inducible JJ cord-001273-plz1ja2e 306 21 ELR ELR NNP cord-001273-plz1ja2e 306 22 − − NNP cord-001273-plz1ja2e 306 23 CXC CXC NNP cord-001273-plz1ja2e 306 24 chemokines chemokine NNS cord-001273-plz1ja2e 306 25 display display NN cord-001273-plz1ja2e 306 26 defensinlike defensinlike RB cord-001273-plz1ja2e 306 27 antimicrobial antimicrobial JJ cord-001273-plz1ja2e 306 28 activity activity NN cord-001273-plz1ja2e 306 29 Listeria Listeria NNP cord-001273-plz1ja2e 306 30 monocytogenes monocytogene VBZ cord-001273-plz1ja2e 306 31 infection infection NN cord-001273-plz1ja2e 306 32 in in IN cord-001273-plz1ja2e 306 33 the the DT cord-001273-plz1ja2e 306 34 face face NN cord-001273-plz1ja2e 306 35 of of IN cord-001273-plz1ja2e 306 36 innate innate JJ cord-001273-plz1ja2e 306 37 immunity immunity NN cord-001273-plz1ja2e 306 38 Illuminating illuminate VBG cord-001273-plz1ja2e 306 39 the the DT cord-001273-plz1ja2e 306 40 landscape landscape NN cord-001273-plz1ja2e 306 41 of of IN cord-001273-plz1ja2e 306 42 host host NN cord-001273-plz1ja2e 306 43 - - HYPH cord-001273-plz1ja2e 306 44 pathogen pathogen NN cord-001273-plz1ja2e 306 45 interactions interaction NNS cord-001273-plz1ja2e 306 46 with with IN cord-001273-plz1ja2e 306 47 the the DT cord-001273-plz1ja2e 306 48 bacterium bacterium NN cord-001273-plz1ja2e 306 49 Listeria Listeria NNP cord-001273-plz1ja2e 306 50 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 307 1 Listeria listeria NN cord-001273-plz1ja2e 307 2 monocytogenes monocytogenes NN cord-001273-plz1ja2e 307 3 multidrug multidrug NN cord-001273-plz1ja2e 307 4 resistance resistance NN cord-001273-plz1ja2e 307 5 transporters transporter NNS cord-001273-plz1ja2e 307 6 activate activate VBP cord-001273-plz1ja2e 307 7 a a DT cord-001273-plz1ja2e 307 8 cytosolic cytosolic JJ cord-001273-plz1ja2e 307 9 surveillance surveillance NN cord-001273-plz1ja2e 307 10 pathway pathway NN cord-001273-plz1ja2e 307 11 of of IN cord-001273-plz1ja2e 307 12 innate innate JJ cord-001273-plz1ja2e 307 13 immunity immunity NN cord-001273-plz1ja2e 307 14 Multiple multiple JJ cord-001273-plz1ja2e 307 15 defects defect NNS cord-001273-plz1ja2e 307 16 of of IN cord-001273-plz1ja2e 307 17 immune immune JJ cord-001273-plz1ja2e 307 18 cell cell NN cord-001273-plz1ja2e 307 19 function function NN cord-001273-plz1ja2e 307 20 in in IN cord-001273-plz1ja2e 307 21 mice mouse NNS cord-001273-plz1ja2e 307 22 with with IN cord-001273-plz1ja2e 307 23 disrupted disrupt VBN cord-001273-plz1ja2e 307 24 interferon interferon NN cord-001273-plz1ja2e 307 25 - - HYPH cord-001273-plz1ja2e 307 26 gamma gamma NN cord-001273-plz1ja2e 307 27 genes gene NNS cord-001273-plz1ja2e 307 28 MyD88 MyD88 NNS cord-001273-plz1ja2e 307 29 and and CC cord-001273-plz1ja2e 307 30 STING sting VB cord-001273-plz1ja2e 307 31 signaling signal VBG cord-001273-plz1ja2e 307 32 pathways pathway NNS cord-001273-plz1ja2e 307 33 are be VBP cord-001273-plz1ja2e 307 34 required require VBN cord-001273-plz1ja2e 307 35 for for IN cord-001273-plz1ja2e 307 36 IRF3-mediated IRF3-mediated NNP cord-001273-plz1ja2e 307 37 IFN IFN NNP cord-001273-plz1ja2e 307 38 - - HYPH cord-001273-plz1ja2e 307 39 β β NNP cord-001273-plz1ja2e 307 40 induction induction NN cord-001273-plz1ja2e 307 41 in in IN cord-001273-plz1ja2e 307 42 response response NN cord-001273-plz1ja2e 307 43 to to IN cord-001273-plz1ja2e 307 44 Brucella Brucella NNP cord-001273-plz1ja2e 307 45 abortus abortus NN cord-001273-plz1ja2e 307 46 infection infection NN cord-001273-plz1ja2e 308 1 The the DT cord-001273-plz1ja2e 308 2 Yin Yin NNP cord-001273-plz1ja2e 308 3 and and CC cord-001273-plz1ja2e 308 4 Yang Yang NNP cord-001273-plz1ja2e 308 5 of of IN cord-001273-plz1ja2e 308 6 type type NN cord-001273-plz1ja2e 309 1 I -PRON- PRP cord-001273-plz1ja2e 309 2 interferon interferon VBD cord-001273-plz1ja2e 309 3 activity activity NN cord-001273-plz1ja2e 309 4 in in IN cord-001273-plz1ja2e 309 5 bacterial bacterial JJ cord-001273-plz1ja2e 309 6 infection infection NN cord-001273-plz1ja2e 309 7 Conjugated conjugate VBN cord-001273-plz1ja2e 309 8 action action NN cord-001273-plz1ja2e 309 9 of of IN cord-001273-plz1ja2e 309 10 two two CD cord-001273-plz1ja2e 309 11 species specie NNS cord-001273-plz1ja2e 309 12 - - HYPH cord-001273-plz1ja2e 309 13 specific specific JJ cord-001273-plz1ja2e 309 14 invasion invasion NN cord-001273-plz1ja2e 309 15 proteins protein NNS cord-001273-plz1ja2e 309 16 for for IN cord-001273-plz1ja2e 309 17 fetoplacental fetoplacental JJ cord-001273-plz1ja2e 309 18 listeriosis listeriosis NN cord-001273-plz1ja2e 310 1 Listeria listeria NN cord-001273-plz1ja2e 310 2 and and CC cord-001273-plz1ja2e 310 3 autophagy autophagy NN cord-001273-plz1ja2e 310 4 escape escape NN cord-001273-plz1ja2e 310 5 : : : cord-001273-plz1ja2e 310 6 involvement involvement NN cord-001273-plz1ja2e 310 7 of of IN cord-001273-plz1ja2e 310 8 InlK InlK NNP cord-001273-plz1ja2e 310 9 , , , cord-001273-plz1ja2e 310 10 an an DT cord-001273-plz1ja2e 310 11 internalin internalin NN cord-001273-plz1ja2e 310 12 - - HYPH cord-001273-plz1ja2e 310 13 like like JJ cord-001273-plz1ja2e 310 14 protein protein NN cord-001273-plz1ja2e 310 15 Interferon interferon NN cord-001273-plz1ja2e 310 16 induction induction NN cord-001273-plz1ja2e 310 17 and and CC cord-001273-plz1ja2e 310 18 function function NN cord-001273-plz1ja2e 310 19 at at IN cord-001273-plz1ja2e 310 20 the the DT cord-001273-plz1ja2e 310 21 mucosal mucosal NN cord-001273-plz1ja2e 310 22 surface surface NN cord-001273-plz1ja2e 311 1 The the DT cord-001273-plz1ja2e 311 2 role role NN cord-001273-plz1ja2e 311 3 of of IN cord-001273-plz1ja2e 311 4 genomic genomic JJ cord-001273-plz1ja2e 311 5 data datum NNS cord-001273-plz1ja2e 311 6 in in IN cord-001273-plz1ja2e 311 7 the the DT cord-001273-plz1ja2e 311 8 discovery discovery NN cord-001273-plz1ja2e 311 9 , , , cord-001273-plz1ja2e 311 10 annotation annotation NN cord-001273-plz1ja2e 311 11 and and CC cord-001273-plz1ja2e 311 12 evolutionary evolutionary JJ cord-001273-plz1ja2e 311 13 interpretation interpretation NN cord-001273-plz1ja2e 311 14 of of IN cord-001273-plz1ja2e 311 15 the the DT cord-001273-plz1ja2e 311 16 interferon interferon NN cord-001273-plz1ja2e 311 17 - - HYPH cord-001273-plz1ja2e 311 18 lambda lambda NN cord-001273-plz1ja2e 311 19 family family NN cord-001273-plz1ja2e 311 20 Listeria Listeria NNP cord-001273-plz1ja2e 311 21 monocytogenesfrom monocytogenesfrom NNP cord-001273-plz1ja2e 311 22 saprophyte saprophyte NNP cord-001273-plz1ja2e 311 23 to to IN cord-001273-plz1ja2e 311 24 intracellular intracellular JJ cord-001273-plz1ja2e 311 25 pathogen pathogen NN cord-001273-plz1ja2e 311 26 Gastrointestinal gastrointestinal JJ cord-001273-plz1ja2e 311 27 phase phase NN cord-001273-plz1ja2e 311 28 of of IN cord-001273-plz1ja2e 311 29 Listeria Listeria NNP cord-001273-plz1ja2e 311 30 monocytogenes monocytogene VBZ cord-001273-plz1ja2e 311 31 infection infection NN cord-001273-plz1ja2e 312 1 Cyclic cyclic JJ cord-001273-plz1ja2e 312 2 GMP GMP NNP cord-001273-plz1ja2e 312 3 - - HYPH cord-001273-plz1ja2e 312 4 AMP AMP NNP cord-001273-plz1ja2e 312 5 synthase synthase NN cord-001273-plz1ja2e 312 6 is be VBZ cord-001273-plz1ja2e 312 7 an an DT cord-001273-plz1ja2e 312 8 innate innate JJ cord-001273-plz1ja2e 312 9 immune immune JJ cord-001273-plz1ja2e 312 10 sensor sensor NN cord-001273-plz1ja2e 312 11 of of IN cord-001273-plz1ja2e 312 12 HIV HIV NNP cord-001273-plz1ja2e 312 13 and and CC cord-001273-plz1ja2e 312 14 other other JJ cord-001273-plz1ja2e 312 15 retroviruses retrovirus NNS cord-001273-plz1ja2e 313 1 Irf3 irf3 NN cord-001273-plz1ja2e 313 2 polymorphism polymorphism NN cord-001273-plz1ja2e 313 3 alters alter VBZ cord-001273-plz1ja2e 313 4 induction induction NN cord-001273-plz1ja2e 313 5 of of IN cord-001273-plz1ja2e 313 6 interferon interferon NN cord-001273-plz1ja2e 313 7 beta beta NN cord-001273-plz1ja2e 313 8 in in IN cord-001273-plz1ja2e 313 9 response response NN cord-001273-plz1ja2e 313 10 to to IN cord-001273-plz1ja2e 313 11 Listeria Listeria NNP cord-001273-plz1ja2e 313 12 monocytogenes monocytogene NNS cord-001273-plz1ja2e 313 13 infection infection NN cord-001273-plz1ja2e 314 1 Recent recent JJ cord-001273-plz1ja2e 314 2 developments development NNS cord-001273-plz1ja2e 314 3 in in IN cord-001273-plz1ja2e 314 4 the the DT cord-001273-plz1ja2e 314 5 transcriptional transcriptional JJ cord-001273-plz1ja2e 314 6 regulation regulation NN cord-001273-plz1ja2e 314 7 of of IN cord-001273-plz1ja2e 314 8 cytolytic cytolytic JJ cord-001273-plz1ja2e 314 9 effector effector NN cord-001273-plz1ja2e 314 10 cells cell NNS cord-001273-plz1ja2e 314 11 Control Control NNP cord-001273-plz1ja2e 314 12 points point NNS cord-001273-plz1ja2e 314 13 in in IN cord-001273-plz1ja2e 314 14 NKT NKT NNP cord-001273-plz1ja2e 314 15 - - HYPH cord-001273-plz1ja2e 314 16 cell cell NN cord-001273-plz1ja2e 314 17 development development NN cord-001273-plz1ja2e 315 1 The the DT cord-001273-plz1ja2e 315 2 Listeria Listeria NNP cord-001273-plz1ja2e 315 3 monocytogenes monocytogenes NN cord-001273-plz1ja2e 315 4 InlC InlC NNP cord-001273-plz1ja2e 315 5 protein protein NN cord-001273-plz1ja2e 315 6 interferes interfere VBZ cord-001273-plz1ja2e 315 7 with with IN cord-001273-plz1ja2e 315 8 innate innate JJ cord-001273-plz1ja2e 315 9 immune immune JJ cord-001273-plz1ja2e 315 10 responses response NNS cord-001273-plz1ja2e 315 11 by by IN cord-001273-plz1ja2e 315 12 targeting target VBG cord-001273-plz1ja2e 315 13 the the DT cord-001273-plz1ja2e 315 14 IκB iκb NN cord-001273-plz1ja2e 315 15 kinase kinase NN cord-001273-plz1ja2e 315 16 subunit subunit NN cord-001273-plz1ja2e 315 17 IKKα ikkα NN cord-001273-plz1ja2e 315 18 Incidence incidence NN cord-001273-plz1ja2e 315 19 of of IN cord-001273-plz1ja2e 315 20 listeriosis listeriosis NN cord-001273-plz1ja2e 315 21 and and CC cord-001273-plz1ja2e 315 22 related relate VBN cord-001273-plz1ja2e 315 23 mortality mortality NN cord-001273-plz1ja2e 315 24 among among IN cord-001273-plz1ja2e 315 25 groups group NNS cord-001273-plz1ja2e 315 26 at at IN cord-001273-plz1ja2e 315 27 risk risk NN cord-001273-plz1ja2e 315 28 of of IN cord-001273-plz1ja2e 315 29 acquiring acquire VBG cord-001273-plz1ja2e 315 30 listeriosis listeriosis NN cord-001273-plz1ja2e 315 31 RIG rig NN cord-001273-plz1ja2e 315 32 - - : cord-001273-plz1ja2e 315 33 I -PRON- PRP cord-001273-plz1ja2e 315 34 detects detect VBZ cord-001273-plz1ja2e 315 35 triphosphorylated triphosphorylate VBN cord-001273-plz1ja2e 315 36 RNA RNA NNP cord-001273-plz1ja2e 315 37 of of IN cord-001273-plz1ja2e 315 38 Listeria Listeria NNP cord-001273-plz1ja2e 315 39 monocytogenes monocytogene NNS cord-001273-plz1ja2e 315 40 during during IN cord-001273-plz1ja2e 315 41 infection infection NN cord-001273-plz1ja2e 315 42 in in IN cord-001273-plz1ja2e 315 43 non non JJ cord-001273-plz1ja2e 315 44 - - JJ cord-001273-plz1ja2e 315 45 immune immune JJ cord-001273-plz1ja2e 315 46 cells cell NNS cord-001273-plz1ja2e 315 47 Importance importance NN cord-001273-plz1ja2e 315 48 of of IN cord-001273-plz1ja2e 315 49 murine murine JJ cord-001273-plz1ja2e 315 50 Vdelta1 Vdelta1 NNP cord-001273-plz1ja2e 315 51 gammadelta gammadelta NNP cord-001273-plz1ja2e 315 52 T t NN cord-001273-plz1ja2e 315 53 cells cell NNS cord-001273-plz1ja2e 315 54 expressing express VBG cord-001273-plz1ja2e 315 55 interferon interferon NN cord-001273-plz1ja2e 315 56 - - HYPH cord-001273-plz1ja2e 315 57 gamma gamma NN cord-001273-plz1ja2e 315 58 and and CC cord-001273-plz1ja2e 315 59 interleukin-17A interleukin-17A NNP cord-001273-plz1ja2e 315 60 in in IN cord-001273-plz1ja2e 315 61 innate innate JJ cord-001273-plz1ja2e 315 62 protection protection NN cord-001273-plz1ja2e 315 63 against against IN cord-001273-plz1ja2e 315 64 Listeria Listeria NNP cord-001273-plz1ja2e 315 65 monocytogenes monocytogene NNS cord-001273-plz1ja2e 315 66 infection infection NN cord-001273-plz1ja2e 316 1 Interferon interferon NN cord-001273-plz1ja2e 316 2 lambda lambda NN cord-001273-plz1ja2e 316 3 4 4 CD cord-001273-plz1ja2e 316 4 signals signal NNS cord-001273-plz1ja2e 316 5 via via IN cord-001273-plz1ja2e 316 6 the the DT cord-001273-plz1ja2e 316 7 IFN IFN NNP cord-001273-plz1ja2e 316 8 - - HYPH cord-001273-plz1ja2e 316 9 λ λ NN cord-001273-plz1ja2e 316 10 receptor receptor NN cord-001273-plz1ja2e 316 11 to to TO cord-001273-plz1ja2e 316 12 regulate regulate VB cord-001273-plz1ja2e 316 13 antiviral antiviral JJ cord-001273-plz1ja2e 316 14 activity activity NN cord-001273-plz1ja2e 316 15 against against IN cord-001273-plz1ja2e 316 16 HCV HCV NNP cord-001273-plz1ja2e 316 17 and and CC cord-001273-plz1ja2e 316 18 coronaviruses coronaviruses NNP cord-001273-plz1ja2e 317 1 Histone histone JJ cord-001273-plz1ja2e 317 2 modifications modification NNS cord-001273-plz1ja2e 317 3 induced induce VBN cord-001273-plz1ja2e 317 4 by by IN cord-001273-plz1ja2e 317 5 a a DT cord-001273-plz1ja2e 317 6 family family NN cord-001273-plz1ja2e 317 7 of of IN cord-001273-plz1ja2e 317 8 bacterial bacterial JJ cord-001273-plz1ja2e 317 9 toxins toxin NNS cord-001273-plz1ja2e 317 10 Specific specific JJ cord-001273-plz1ja2e 317 11 immunity immunity NN cord-001273-plz1ja2e 317 12 to to IN cord-001273-plz1ja2e 317 13 Listeria Listeria NNP cord-001273-plz1ja2e 317 14 monocytogenes monocytogene NNS cord-001273-plz1ja2e 317 15 in in IN cord-001273-plz1ja2e 317 16 the the DT cord-001273-plz1ja2e 317 17 absence absence NN cord-001273-plz1ja2e 317 18 of of IN cord-001273-plz1ja2e 317 19 IFN IFN NNP cord-001273-plz1ja2e 317 20 gamma gamma NN cord-001273-plz1ja2e 317 21 25 25 CD cord-001273-plz1ja2e 317 22 years year NNS cord-001273-plz1ja2e 317 23 of of IN cord-001273-plz1ja2e 317 24 interferon interferon NN cord-001273-plz1ja2e 317 25 - - HYPH cord-001273-plz1ja2e 317 26 based base VBN cord-001273-plz1ja2e 317 27 treatment treatment NN cord-001273-plz1ja2e 317 28 of of IN cord-001273-plz1ja2e 317 29 chronic chronic JJ cord-001273-plz1ja2e 317 30 hepatitis hepatitis NN cord-001273-plz1ja2e 317 31 C c NN cord-001273-plz1ja2e 317 32 : : : cord-001273-plz1ja2e 317 33 an an DT cord-001273-plz1ja2e 317 34 epoch epoch NN cord-001273-plz1ja2e 317 35 coming come VBG cord-001273-plz1ja2e 317 36 to to IN cord-001273-plz1ja2e 317 37 an an DT cord-001273-plz1ja2e 317 38 end end NN cord-001273-plz1ja2e 317 39 Type type NN cord-001273-plz1ja2e 317 40 I -PRON- PRP cord-001273-plz1ja2e 317 41 IFN IFN NNP cord-001273-plz1ja2e 317 42 signaling signal VBG cord-001273-plz1ja2e 317 43 constrains constrain VBZ cord-001273-plz1ja2e 317 44 IL-17A IL-17A NNP cord-001273-plz1ja2e 317 45 / / SYM cord-001273-plz1ja2e 317 46 F F NNP cord-001273-plz1ja2e 317 47 secretion secretion NN cord-001273-plz1ja2e 317 48 by by IN cord-001273-plz1ja2e 317 49 gammadelta gammadelta NNP cord-001273-plz1ja2e 317 50 T T NNP cord-001273-plz1ja2e 317 51 cells cell NNS cord-001273-plz1ja2e 317 52 during during IN cord-001273-plz1ja2e 317 53 bacterial bacterial JJ cord-001273-plz1ja2e 317 54 infections infection NNS cord-001273-plz1ja2e 317 55 Human human JJ cord-001273-plz1ja2e 317 56 but but CC cord-001273-plz1ja2e 318 1 not not RB cord-001273-plz1ja2e 318 2 mouse mouse NN cord-001273-plz1ja2e 318 3 hepatocytes hepatocyte NNS cord-001273-plz1ja2e 318 4 respond respond VBP cord-001273-plz1ja2e 318 5 to to IN cord-001273-plz1ja2e 318 6 interferon interferon NN cord-001273-plz1ja2e 318 7 - - HYPH cord-001273-plz1ja2e 318 8 lambda lambda NN cord-001273-plz1ja2e 318 9 in in IN cord-001273-plz1ja2e 318 10 vivo vivo NNP cord-001273-plz1ja2e 318 11 Animal Animal NNP cord-001273-plz1ja2e 318 12 models model NNS cord-001273-plz1ja2e 318 13 of of IN cord-001273-plz1ja2e 318 14 listeriosis listeriosis NN cord-001273-plz1ja2e 318 15 : : : cord-001273-plz1ja2e 319 1 a a DT cord-001273-plz1ja2e 319 2 comparative comparative JJ cord-001273-plz1ja2e 319 3 review review NN cord-001273-plz1ja2e 319 4 of of IN cord-001273-plz1ja2e 319 5 the the DT cord-001273-plz1ja2e 319 6 current current JJ cord-001273-plz1ja2e 319 7 state state NN cord-001273-plz1ja2e 319 8 of of IN cord-001273-plz1ja2e 319 9 the the DT cord-001273-plz1ja2e 319 10 art art NN cord-001273-plz1ja2e 319 11 and and CC cord-001273-plz1ja2e 319 12 lessons lesson NNS cord-001273-plz1ja2e 319 13 learned learn VBD cord-001273-plz1ja2e 319 14 Chronic Chronic NNP cord-001273-plz1ja2e 319 15 granulomatous granulomatous JJ cord-001273-plz1ja2e 319 16 disease disease NN cord-001273-plz1ja2e 319 17 Type type NN cord-001273-plz1ja2e 320 1 I -PRON- PRP cord-001273-plz1ja2e 320 2 interferon interferon VBD cord-001273-plz1ja2e 320 3 gene gene NN cord-001273-plz1ja2e 320 4 induction induction NN cord-001273-plz1ja2e 320 5 by by IN cord-001273-plz1ja2e 320 6 the the DT cord-001273-plz1ja2e 320 7 interferon interferon NN cord-001273-plz1ja2e 320 8 regulatory regulatory JJ cord-001273-plz1ja2e 320 9 factor factor NN cord-001273-plz1ja2e 320 10 family family NN cord-001273-plz1ja2e 320 11 of of IN cord-001273-plz1ja2e 320 12 transcription transcription NN cord-001273-plz1ja2e 320 13 factors factor NNS cord-001273-plz1ja2e 321 1 IRF-7 IRF-7 NNP cord-001273-plz1ja2e 321 2 is be VBZ cord-001273-plz1ja2e 321 3 the the DT cord-001273-plz1ja2e 321 4 master master NN cord-001273-plz1ja2e 321 5 regulator regulator NN cord-001273-plz1ja2e 321 6 of of IN cord-001273-plz1ja2e 321 7 type type NN cord-001273-plz1ja2e 321 8 - - : cord-001273-plz1ja2e 321 9 I -PRON- PRP cord-001273-plz1ja2e 321 10 interferon interferon NN cord-001273-plz1ja2e 321 11 - - HYPH cord-001273-plz1ja2e 321 12 dependent dependent JJ cord-001273-plz1ja2e 321 13 immune immune JJ cord-001273-plz1ja2e 321 14 responses response NNS cord-001273-plz1ja2e 322 1 Cross cross NN cord-001273-plz1ja2e 322 2 - - NN cord-001273-plz1ja2e 322 3 regulation regulation NN cord-001273-plz1ja2e 322 4 of of IN cord-001273-plz1ja2e 322 5 signaling signal VBG cord-001273-plz1ja2e 322 6 pathways pathway NNS cord-001273-plz1ja2e 322 7 by by IN cord-001273-plz1ja2e 322 8 interferon interferon NN cord-001273-plz1ja2e 322 9 - - HYPH cord-001273-plz1ja2e 322 10 gamma gamma NN cord-001273-plz1ja2e 322 11 : : : cord-001273-plz1ja2e 322 12 implications implication NNS cord-001273-plz1ja2e 322 13 for for IN cord-001273-plz1ja2e 322 14 immune immune JJ cord-001273-plz1ja2e 322 15 responses response NNS cord-001273-plz1ja2e 322 16 and and CC cord-001273-plz1ja2e 322 17 autoimmune autoimmune JJ cord-001273-plz1ja2e 322 18 diseases disease NNS cord-001273-plz1ja2e 323 1 Immune immune JJ cord-001273-plz1ja2e 323 2 response response NN cord-001273-plz1ja2e 323 3 in in IN cord-001273-plz1ja2e 323 4 mice mouse NNS cord-001273-plz1ja2e 323 5 that that WDT cord-001273-plz1ja2e 323 6 lack lack VBP cord-001273-plz1ja2e 323 7 the the DT cord-001273-plz1ja2e 323 8 interferon interferon NN cord-001273-plz1ja2e 323 9 - - HYPH cord-001273-plz1ja2e 323 10 gamma gamma NN cord-001273-plz1ja2e 323 11 receptor receptor NN cord-001273-plz1ja2e 323 12 Virus Virus NNP cord-001273-plz1ja2e 323 13 Interference Interference NNP cord-001273-plz1ja2e 323 14 . . . cord-001273-plz1ja2e 324 1 I. I. NNP cord-001273-plz1ja2e 325 1 The the DT cord-001273-plz1ja2e 325 2 Interferon Interferon NNP cord-001273-plz1ja2e 325 3 Mechanisms Mechanisms NNPS cord-001273-plz1ja2e 325 4 of of IN cord-001273-plz1ja2e 325 5 type type NN cord-001273-plz1ja2e 325 6 III iii CD cord-001273-plz1ja2e 326 1 interferon interferon NN cord-001273-plz1ja2e 326 2 expression expression NN cord-001273-plz1ja2e 326 3 MyD88 MyD88 NNS cord-001273-plz1ja2e 326 4 and and CC cord-001273-plz1ja2e 327 1 Type type NN cord-001273-plz1ja2e 327 2 I -PRON- PRP cord-001273-plz1ja2e 328 1 interferon interferon NNP cord-001273-plz1ja2e 328 2 receptor receptor NN cord-001273-plz1ja2e 328 3 - - HYPH cord-001273-plz1ja2e 328 4 mediated mediate VBN cord-001273-plz1ja2e 328 5 chemokine chemokine NN cord-001273-plz1ja2e 328 6 induction induction NN cord-001273-plz1ja2e 328 7 and and CC cord-001273-plz1ja2e 328 8 monocyte monocyte NNP cord-001273-plz1ja2e 328 9 recruitment recruitment NNP cord-001273-plz1ja2e 328 10 during during IN cord-001273-plz1ja2e 328 11 Listeria Listeria NNP cord-001273-plz1ja2e 328 12 monocytogenes monocytogene VBZ cord-001273-plz1ja2e 328 13 infection infection NN cord-001273-plz1ja2e 329 1 Interferon interferon NN cord-001273-plz1ja2e 329 2 - - HYPH cord-001273-plz1ja2e 329 3 gamma gamma NN cord-001273-plz1ja2e 329 4 - - HYPH cord-001273-plz1ja2e 329 5 receptor receptor NN cord-001273-plz1ja2e 329 6 deficiency deficiency NN cord-001273-plz1ja2e 329 7 in in IN cord-001273-plz1ja2e 329 8 an an DT cord-001273-plz1ja2e 329 9 infant infant NN cord-001273-plz1ja2e 329 10 with with IN cord-001273-plz1ja2e 329 11 fatal fatal JJ cord-001273-plz1ja2e 329 12 bacille bacille NNP cord-001273-plz1ja2e 329 13 Calmette Calmette NNP cord-001273-plz1ja2e 329 14 - - HYPH cord-001273-plz1ja2e 329 15 Guérin Guérin NNP cord-001273-plz1ja2e 329 16 infection infection NN cord-001273-plz1ja2e 329 17 IL-12 IL-12 NNP cord-001273-plz1ja2e 329 18 and and CC cord-001273-plz1ja2e 329 19 IFN IFN NNP cord-001273-plz1ja2e 329 20 - - HYPH cord-001273-plz1ja2e 329 21 gamma gamma NNP cord-001273-plz1ja2e 329 22 in in IN cord-001273-plz1ja2e 329 23 host host NN cord-001273-plz1ja2e 329 24 defense defense NN cord-001273-plz1ja2e 329 25 against against IN cord-001273-plz1ja2e 329 26 mycobacteria mycobacterium NNS cord-001273-plz1ja2e 329 27 and and CC cord-001273-plz1ja2e 329 28 salmonella salmonella NN cord-001273-plz1ja2e 329 29 in in IN cord-001273-plz1ja2e 329 30 mice mouse NNS cord-001273-plz1ja2e 329 31 and and CC cord-001273-plz1ja2e 329 32 men man NNS cord-001273-plz1ja2e 329 33 Mice mouse NNS cord-001273-plz1ja2e 329 34 that that WDT cord-001273-plz1ja2e 329 35 lack lack VBP cord-001273-plz1ja2e 329 36 the the DT cord-001273-plz1ja2e 329 37 interferon interferon NN cord-001273-plz1ja2e 329 38 - - HYPH cord-001273-plz1ja2e 329 39 gamma gamma NN cord-001273-plz1ja2e 329 40 receptor receptor NN cord-001273-plz1ja2e 329 41 have have VBP cord-001273-plz1ja2e 329 42 profoundly profoundly RB cord-001273-plz1ja2e 329 43 altered alter VBN cord-001273-plz1ja2e 329 44 responses response NNS cord-001273-plz1ja2e 329 45 to to IN cord-001273-plz1ja2e 329 46 infection infection NN cord-001273-plz1ja2e 329 47 with with IN cord-001273-plz1ja2e 329 48 Bacillus Bacillus NNP cord-001273-plz1ja2e 329 49 Calmette Calmette NNP cord-001273-plz1ja2e 329 50 - - HYPH cord-001273-plz1ja2e 329 51 Guérin Guérin NNP cord-001273-plz1ja2e 329 52 and and CC cord-001273-plz1ja2e 329 53 subsequent subsequent JJ cord-001273-plz1ja2e 329 54 challenge challenge NN cord-001273-plz1ja2e 329 55 with with IN cord-001273-plz1ja2e 329 56 lipopolysaccharide lipopolysaccharide NN cord-001273-plz1ja2e 329 57 Demonstration demonstration NN cord-001273-plz1ja2e 329 58 of of IN cord-001273-plz1ja2e 329 59 an an DT cord-001273-plz1ja2e 329 60 interferon interferon NN cord-001273-plz1ja2e 329 61 gamma gamma NN cord-001273-plz1ja2e 329 62 - - HYPH cord-001273-plz1ja2e 329 63 dependent dependent JJ cord-001273-plz1ja2e 329 64 tumor tumor NN cord-001273-plz1ja2e 329 65 surveillance surveillance NN cord-001273-plz1ja2e 329 66 system system NN cord-001273-plz1ja2e 329 67 in in IN cord-001273-plz1ja2e 329 68 immunocompetent immunocompetent JJ cord-001273-plz1ja2e 329 69 mice mouse NNS cord-001273-plz1ja2e 329 70 Type type NN cord-001273-plz1ja2e 330 1 I -PRON- PRP cord-001273-plz1ja2e 330 2 IFNs ifns VBP cord-001273-plz1ja2e 330 3 downregulate downregulate VB cord-001273-plz1ja2e 330 4 myeloid myeloid JJ cord-001273-plz1ja2e 330 5 cell cell NN cord-001273-plz1ja2e 330 6 IFN IFN NNP cord-001273-plz1ja2e 330 7 - - HYPH cord-001273-plz1ja2e 330 8 gamma gamma NN cord-001273-plz1ja2e 330 9 receptor receptor NN cord-001273-plz1ja2e 330 10 by by IN cord-001273-plz1ja2e 330 11 inducing induce VBG cord-001273-plz1ja2e 330 12 recruitment recruitment NN cord-001273-plz1ja2e 330 13 of of IN cord-001273-plz1ja2e 330 14 an an DT cord-001273-plz1ja2e 330 15 early early JJ cord-001273-plz1ja2e 330 16 growth growth NN cord-001273-plz1ja2e 330 17 response response NN cord-001273-plz1ja2e 330 18 3 3 CD cord-001273-plz1ja2e 330 19 / / SYM cord-001273-plz1ja2e 330 20 NGFI NGFI NNP cord-001273-plz1ja2e 330 21 - - HYPH cord-001273-plz1ja2e 330 22 A a DT cord-001273-plz1ja2e 330 23 binding bind VBG cord-001273-plz1ja2e 330 24 protein protein NN cord-001273-plz1ja2e 330 25 1 1 CD cord-001273-plz1ja2e 330 26 complex complex NN cord-001273-plz1ja2e 330 27 that that WDT cord-001273-plz1ja2e 330 28 silences silence VBZ cord-001273-plz1ja2e 330 29 ifngr1 ifngr1 JJ cord-001273-plz1ja2e 330 30 transcription transcription NN cord-001273-plz1ja2e 330 31 Route Route NNP cord-001273-plz1ja2e 330 32 of of IN cord-001273-plz1ja2e 330 33 infection infection NN cord-001273-plz1ja2e 331 1 determines determine VBZ cord-001273-plz1ja2e 331 2 the the DT cord-001273-plz1ja2e 331 3 impact impact NN cord-001273-plz1ja2e 331 4 of of IN cord-001273-plz1ja2e 331 5 type type NN cord-001273-plz1ja2e 331 6 I -PRON- PRP cord-001273-plz1ja2e 331 7 interferons interferon NNS cord-001273-plz1ja2e 331 8 on on IN cord-001273-plz1ja2e 331 9 innate innate JJ cord-001273-plz1ja2e 331 10 immunity immunity NN cord-001273-plz1ja2e 331 11 to to IN cord-001273-plz1ja2e 331 12 Listeria Listeria NNP cord-001273-plz1ja2e 331 13 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 331 14 Conditional conditional JJ cord-001273-plz1ja2e 331 15 Stat1 stat1 JJ cord-001273-plz1ja2e 331 16 ablation ablation NN cord-001273-plz1ja2e 331 17 reveals reveal VBZ cord-001273-plz1ja2e 331 18 the the DT cord-001273-plz1ja2e 331 19 importance importance NN cord-001273-plz1ja2e 331 20 of of IN cord-001273-plz1ja2e 331 21 interferon interferon NN cord-001273-plz1ja2e 331 22 signaling signal VBG cord-001273-plz1ja2e 331 23 for for IN cord-001273-plz1ja2e 331 24 immunity immunity NN cord-001273-plz1ja2e 331 25 to to IN cord-001273-plz1ja2e 331 26 Listeria Listeria NNP cord-001273-plz1ja2e 331 27 monocytogenes monocytogene NNS cord-001273-plz1ja2e 331 28 infection infection NN cord-001273-plz1ja2e 332 1 A a DT cord-001273-plz1ja2e 332 2 family family NN cord-001273-plz1ja2e 332 3 of of IN cord-001273-plz1ja2e 332 4 IFN IFN NNP cord-001273-plz1ja2e 332 5 - - HYPH cord-001273-plz1ja2e 332 6 gamma gamma NN cord-001273-plz1ja2e 332 7 - - HYPH cord-001273-plz1ja2e 332 8 inducible inducible JJ cord-001273-plz1ja2e 332 9 65-kD 65-kd CD cord-001273-plz1ja2e 333 1 GTPases GTPases NNP cord-001273-plz1ja2e 333 2 protects protect VBZ cord-001273-plz1ja2e 333 3 against against IN cord-001273-plz1ja2e 333 4 bacterial bacterial JJ cord-001273-plz1ja2e 333 5 infection infection NN cord-001273-plz1ja2e 334 1 IFN IFN NNP cord-001273-plz1ja2e 334 2 - - HYPH cord-001273-plz1ja2e 334 3 λs λs NNP cord-001273-plz1ja2e 334 4 IFN IFN NNP cord-001273-plz1ja2e 334 5 - - HYPH cord-001273-plz1ja2e 334 6 λs λs NNP cord-001273-plz1ja2e 334 7 mediate mediate VB cord-001273-plz1ja2e 334 8 antiviral antiviral JJ cord-001273-plz1ja2e 334 9 protection protection NN cord-001273-plz1ja2e 334 10 through through IN cord-001273-plz1ja2e 334 11 a a DT cord-001273-plz1ja2e 334 12 distinct distinct JJ cord-001273-plz1ja2e 334 13 class class NN cord-001273-plz1ja2e 334 14 II ii NN cord-001273-plz1ja2e 334 15 cytokine cytokine NN cord-001273-plz1ja2e 334 16 receptor receptor NN cord-001273-plz1ja2e 334 17 complex complex NN cord-001273-plz1ja2e 334 18 T T NNP cord-001273-plz1ja2e 334 19 - - HYPH cord-001273-plz1ja2e 334 20 bet bet NN cord-001273-plz1ja2e 334 21 : : : cord-001273-plz1ja2e 334 22 a a DT cord-001273-plz1ja2e 334 23 bridge bridge NN cord-001273-plz1ja2e 334 24 between between IN cord-001273-plz1ja2e 334 25 innate innate JJ cord-001273-plz1ja2e 334 26 and and CC cord-001273-plz1ja2e 334 27 adaptive adaptive JJ cord-001273-plz1ja2e 334 28 immunity immunity NN cord-001273-plz1ja2e 334 29 Bacteria Bacteria NNS cord-001273-plz1ja2e 334 30 tune tune VBP cord-001273-plz1ja2e 334 31 interferon interferon NN cord-001273-plz1ja2e 334 32 responses response NNS cord-001273-plz1ja2e 334 33 by by IN cord-001273-plz1ja2e 334 34 playing play VBG cord-001273-plz1ja2e 334 35 with with IN cord-001273-plz1ja2e 334 36 chromatin chromatin NN cord-001273-plz1ja2e 334 37 Structural structural JJ cord-001273-plz1ja2e 334 38 basis basis NN cord-001273-plz1ja2e 334 39 for for IN cord-001273-plz1ja2e 334 40 the the DT cord-001273-plz1ja2e 334 41 inhibition inhibition NN cord-001273-plz1ja2e 334 42 of of IN cord-001273-plz1ja2e 334 43 the the DT cord-001273-plz1ja2e 334 44 chromatin chromatin NN cord-001273-plz1ja2e 334 45 repressor repressor NN cord-001273-plz1ja2e 334 46 BAHD1 BAHD1 NNS cord-001273-plz1ja2e 334 47 by by IN cord-001273-plz1ja2e 334 48 the the DT cord-001273-plz1ja2e 334 49 bacterial bacterial JJ cord-001273-plz1ja2e 334 50 nucleomodulin nucleomodulin NN cord-001273-plz1ja2e 334 51 LntA LntA NNP cord-001273-plz1ja2e 334 52 A A NNP cord-001273-plz1ja2e 335 1 bacterial bacterial JJ cord-001273-plz1ja2e 335 2 protein protein NN cord-001273-plz1ja2e 335 3 targets target VBZ cord-001273-plz1ja2e 335 4 the the DT cord-001273-plz1ja2e 335 5 BAHD1 BAHD1 NNS cord-001273-plz1ja2e 335 6 chromatin chromatin NN cord-001273-plz1ja2e 335 7 complex complex JJ cord-001273-plz1ja2e 335 8 to to TO cord-001273-plz1ja2e 335 9 stimulate stimulate VB cord-001273-plz1ja2e 335 10 type type NN cord-001273-plz1ja2e 335 11 III iii CD cord-001273-plz1ja2e 335 12 interferon interferon NN cord-001273-plz1ja2e 335 13 response response NN cord-001273-plz1ja2e 335 14 Human human JJ cord-001273-plz1ja2e 335 15 listeriosis listeriosis NN cord-001273-plz1ja2e 335 16 and and CC cord-001273-plz1ja2e 335 17 animal animal NN cord-001273-plz1ja2e 335 18 models model NNS cord-001273-plz1ja2e 336 1 A a DT cord-001273-plz1ja2e 336 2 transgenic transgenic JJ cord-001273-plz1ja2e 336 3 model model NN cord-001273-plz1ja2e 336 4 for for IN cord-001273-plz1ja2e 336 5 listeriosis listeriosis NN cord-001273-plz1ja2e 336 6 : : : cord-001273-plz1ja2e 336 7 role role NN cord-001273-plz1ja2e 336 8 of of IN cord-001273-plz1ja2e 336 9 internalin internalin NNP cord-001273-plz1ja2e 336 10 in in IN cord-001273-plz1ja2e 336 11 crossing cross VBG cord-001273-plz1ja2e 336 12 the the DT cord-001273-plz1ja2e 336 13 intestinal intestinal JJ cord-001273-plz1ja2e 336 14 barrier barrier NN cord-001273-plz1ja2e 336 15 Induction Induction NNP cord-001273-plz1ja2e 336 16 and and CC cord-001273-plz1ja2e 336 17 function function NN cord-001273-plz1ja2e 336 18 of of IN cord-001273-plz1ja2e 336 19 type type NN cord-001273-plz1ja2e 336 20 I -PRON- PRP cord-001273-plz1ja2e 336 21 and and CC cord-001273-plz1ja2e 336 22 III III NNP cord-001273-plz1ja2e 336 23 interferon interferon NN cord-001273-plz1ja2e 336 24 in in IN cord-001273-plz1ja2e 336 25 response response NN cord-001273-plz1ja2e 336 26 to to IN cord-001273-plz1ja2e 336 27 viral viral JJ cord-001273-plz1ja2e 336 28 infection infection NN cord-001273-plz1ja2e 336 29 DUOX2-derived DUOX2-derived : cord-001273-plz1ja2e 336 30 reactive reactive JJ cord-001273-plz1ja2e 336 31 oxygen oxygen NN cord-001273-plz1ja2e 336 32 species specie NNS cord-001273-plz1ja2e 336 33 are be VBP cord-001273-plz1ja2e 336 34 effectors effector NNS cord-001273-plz1ja2e 336 35 of of IN cord-001273-plz1ja2e 336 36 NOD2-mediated nod2-mediated JJ cord-001273-plz1ja2e 336 37 antibacterial antibacterial JJ cord-001273-plz1ja2e 336 38 responses response NNS cord-001273-plz1ja2e 337 1 Listeriosis Listeriosis NNP cord-001273-plz1ja2e 337 2 Cellular cellular JJ cord-001273-plz1ja2e 337 3 resistance resistance NN cord-001273-plz1ja2e 337 4 to to IN cord-001273-plz1ja2e 337 5 infection infection NN cord-001273-plz1ja2e 337 6 IFN IFN NNP cord-001273-plz1ja2e 337 7 - - HYPH cord-001273-plz1ja2e 337 8 inducible inducible JJ cord-001273-plz1ja2e 337 9 GTPases gtpase NNS cord-001273-plz1ja2e 337 10 and and CC cord-001273-plz1ja2e 337 11 immunity immunity NN cord-001273-plz1ja2e 337 12 to to IN cord-001273-plz1ja2e 337 13 intracellular intracellular JJ cord-001273-plz1ja2e 337 14 pathogens pathogen NNS cord-001273-plz1ja2e 338 1 Interferon interferon NN cord-001273-plz1ja2e 338 2 - - HYPH cord-001273-plz1ja2e 338 3 inducible inducible JJ cord-001273-plz1ja2e 338 4 effector effector NN cord-001273-plz1ja2e 338 5 mechanisms mechanism NNS cord-001273-plz1ja2e 338 6 in in IN cord-001273-plz1ja2e 338 7 cellautonomous cellautonomous JJ cord-001273-plz1ja2e 338 8 immunity immunity NN cord-001273-plz1ja2e 338 9 Role role NN cord-001273-plz1ja2e 338 10 of of IN cord-001273-plz1ja2e 338 11 type type NN cord-001273-plz1ja2e 339 1 I -PRON- PRP cord-001273-plz1ja2e 339 2 interferons interferon NNS cord-001273-plz1ja2e 339 3 in in IN cord-001273-plz1ja2e 339 4 inflammasome inflammasome NN cord-001273-plz1ja2e 339 5 activation activation NN cord-001273-plz1ja2e 339 6 , , , cord-001273-plz1ja2e 339 7 cell cell NN cord-001273-plz1ja2e 339 8 death death NN cord-001273-plz1ja2e 339 9 , , , cord-001273-plz1ja2e 339 10 and and CC cord-001273-plz1ja2e 339 11 disease disease NN cord-001273-plz1ja2e 339 12 during during IN cord-001273-plz1ja2e 339 13 microbial microbial JJ cord-001273-plz1ja2e 339 14 infection infection NN cord-001273-plz1ja2e 339 15 Type type NN cord-001273-plz1ja2e 339 16 I -PRON- PRP cord-001273-plz1ja2e 339 17 IFN IFN NNP cord-001273-plz1ja2e 339 18 signaling signal VBG cord-001273-plz1ja2e 339 19 is be VBZ cord-001273-plz1ja2e 339 20 crucial crucial JJ cord-001273-plz1ja2e 339 21 for for IN cord-001273-plz1ja2e 339 22 host host NN cord-001273-plz1ja2e 339 23 resistance resistance NN cord-001273-plz1ja2e 339 24 against against IN cord-001273-plz1ja2e 339 25 different different JJ cord-001273-plz1ja2e 339 26 species specie NNS cord-001273-plz1ja2e 339 27 of of IN cord-001273-plz1ja2e 339 28 pathogenic pathogenic JJ cord-001273-plz1ja2e 339 29 bacteria bacteria NNS cord-001273-plz1ja2e 339 30 Regulation regulation NN cord-001273-plz1ja2e 339 31 of of IN cord-001273-plz1ja2e 339 32 mouse mouse NN cord-001273-plz1ja2e 339 33 NK NK NNP cord-001273-plz1ja2e 339 34 cell cell NN cord-001273-plz1ja2e 339 35 development development NN cord-001273-plz1ja2e 339 36 and and CC cord-001273-plz1ja2e 339 37 function function NN cord-001273-plz1ja2e 339 38 by by IN cord-001273-plz1ja2e 339 39 cytokines cytokine NNS cord-001273-plz1ja2e 339 40 Interferons Interferons NNPS cord-001273-plz1ja2e 339 41 α α NN cord-001273-plz1ja2e 339 42 and and CC cord-001273-plz1ja2e 339 43 λ λ NN cord-001273-plz1ja2e 339 44 inhibit inhibit VBP cord-001273-plz1ja2e 339 45 hepatitis hepatitis NN cord-001273-plz1ja2e 339 46 C c NN cord-001273-plz1ja2e 339 47 virus virus NN cord-001273-plz1ja2e 339 48 replication replication NN cord-001273-plz1ja2e 339 49 with with IN cord-001273-plz1ja2e 339 50 distinct distinct JJ cord-001273-plz1ja2e 339 51 signal signal NN cord-001273-plz1ja2e 339 52 transduction transduction NN cord-001273-plz1ja2e 339 53 and and CC cord-001273-plz1ja2e 339 54 gene gene NN cord-001273-plz1ja2e 339 55 regulation regulation NN cord-001273-plz1ja2e 339 56 kinetics kinetics NN cord-001273-plz1ja2e 340 1 Staphylococcus staphylococcus NN cord-001273-plz1ja2e 340 2 aureus aureus NN cord-001273-plz1ja2e 340 3 activates activate VBZ cord-001273-plz1ja2e 340 4 type type NN cord-001273-plz1ja2e 341 1 I -PRON- PRP cord-001273-plz1ja2e 341 2 IFN IFN NNP cord-001273-plz1ja2e 341 3 signaling signal VBG cord-001273-plz1ja2e 341 4 in in IN cord-001273-plz1ja2e 341 5 mice mouse NNS cord-001273-plz1ja2e 341 6 and and CC cord-001273-plz1ja2e 341 7 humans human NNS cord-001273-plz1ja2e 341 8 through through IN cord-001273-plz1ja2e 341 9 the the DT cord-001273-plz1ja2e 341 10 Xr Xr NNP cord-001273-plz1ja2e 341 11 repeated repeat VBN cord-001273-plz1ja2e 341 12 sequences sequence NNS cord-001273-plz1ja2e 341 13 of of IN cord-001273-plz1ja2e 341 14 protein protein NN cord-001273-plz1ja2e 341 15 A a DT cord-001273-plz1ja2e 341 16 A a DT cord-001273-plz1ja2e 341 17 specific specific JJ cord-001273-plz1ja2e 341 18 gene gene NN cord-001273-plz1ja2e 341 19 expression expression NN cord-001273-plz1ja2e 341 20 program program NN cord-001273-plz1ja2e 341 21 triggered trigger VBN cord-001273-plz1ja2e 341 22 by by IN cord-001273-plz1ja2e 341 23 Gram gram NN cord-001273-plz1ja2e 341 24 - - HYPH cord-001273-plz1ja2e 341 25 positive positive JJ cord-001273-plz1ja2e 341 26 bacteria bacteria NNS cord-001273-plz1ja2e 341 27 in in IN cord-001273-plz1ja2e 341 28 the the DT cord-001273-plz1ja2e 341 29 cytosol cytosol NN cord-001273-plz1ja2e 341 30 Induction Induction NNP cord-001273-plz1ja2e 341 31 of of IN cord-001273-plz1ja2e 341 32 type type NN cord-001273-plz1ja2e 342 1 I -PRON- PRP cord-001273-plz1ja2e 342 2 interferons interferon NNS cord-001273-plz1ja2e 342 3 by by IN cord-001273-plz1ja2e 342 4 bacteria bacteria NNS cord-001273-plz1ja2e 343 1 What what WP cord-001273-plz1ja2e 343 2 have have VBP cord-001273-plz1ja2e 343 3 we -PRON- PRP cord-001273-plz1ja2e 343 4 learned learn VBN cord-001273-plz1ja2e 343 5 from from IN cord-001273-plz1ja2e 343 6 the the DT cord-001273-plz1ja2e 343 7 IL28 IL28 NNP cord-001273-plz1ja2e 343 8 receptor receptor NN cord-001273-plz1ja2e 343 9 knockout knockout NN cord-001273-plz1ja2e 343 10 mouse mouse NN cord-001273-plz1ja2e 343 11 ? ? . cord-001273-plz1ja2e 344 1 Localized localized JJ cord-001273-plz1ja2e 344 2 reactive reactive JJ cord-001273-plz1ja2e 344 3 oxygen oxygen NN cord-001273-plz1ja2e 344 4 and and CC cord-001273-plz1ja2e 344 5 nitrogen nitrogen NN cord-001273-plz1ja2e 344 6 intermediates intermediate NNS cord-001273-plz1ja2e 344 7 inhibit inhibit VBP cord-001273-plz1ja2e 344 8 escape escape NN cord-001273-plz1ja2e 344 9 of of IN cord-001273-plz1ja2e 344 10 Listeria Listeria NNP cord-001273-plz1ja2e 344 11 monocytogenes monocytogene NNS cord-001273-plz1ja2e 344 12 from from IN cord-001273-plz1ja2e 344 13 vacuoles vacuole NNS cord-001273-plz1ja2e 344 14 in in IN cord-001273-plz1ja2e 344 15 activated activate VBN cord-001273-plz1ja2e 344 16 macrophages macrophage NNS cord-001273-plz1ja2e 344 17 Whatever whatever WDT cord-001273-plz1ja2e 344 18 turns turn VBZ cord-001273-plz1ja2e 344 19 you -PRON- PRP cord-001273-plz1ja2e 344 20 on on IN cord-001273-plz1ja2e 344 21 : : : cord-001273-plz1ja2e 344 22 accessory accessory NN cord-001273-plz1ja2e 344 23 - - HYPH cord-001273-plz1ja2e 344 24 celldependent celldependent NN cord-001273-plz1ja2e 344 25 activation activation NN cord-001273-plz1ja2e 344 26 of of IN cord-001273-plz1ja2e 344 27 NK NK NNP cord-001273-plz1ja2e 344 28 cells cell NNS cord-001273-plz1ja2e 344 29 by by IN cord-001273-plz1ja2e 344 30 pathogens pathogen NNS cord-001273-plz1ja2e 344 31 A a DT cord-001273-plz1ja2e 344 32 mutation mutation NN cord-001273-plz1ja2e 344 33 in in IN cord-001273-plz1ja2e 344 34 the the DT cord-001273-plz1ja2e 344 35 interferon interferon NN cord-001273-plz1ja2e 344 36 - - HYPH cord-001273-plz1ja2e 344 37 gamma gamma NN cord-001273-plz1ja2e 344 38 - - HYPH cord-001273-plz1ja2e 344 39 receptor receptor NN cord-001273-plz1ja2e 344 40 gene gene NN cord-001273-plz1ja2e 344 41 and and CC cord-001273-plz1ja2e 344 42 susceptibility susceptibility NN cord-001273-plz1ja2e 344 43 to to IN cord-001273-plz1ja2e 344 44 mycobacterial mycobacterial NNP cord-001273-plz1ja2e 344 45 infection infection NN cord-001273-plz1ja2e 344 46 Transcytosis Transcytosis NNP cord-001273-plz1ja2e 344 47 of of IN cord-001273-plz1ja2e 344 48 Listeria Listeria NNP cord-001273-plz1ja2e 344 49 monocytogenes monocytogene NNS cord-001273-plz1ja2e 344 50 across across IN cord-001273-plz1ja2e 344 51 the the DT cord-001273-plz1ja2e 344 52 intestinal intestinal JJ cord-001273-plz1ja2e 344 53 barrier barrier NN cord-001273-plz1ja2e 344 54 upon upon IN cord-001273-plz1ja2e 344 55 specific specific JJ cord-001273-plz1ja2e 344 56 targeting targeting NN cord-001273-plz1ja2e 344 57 of of IN cord-001273-plz1ja2e 344 58 goblet goblet NN cord-001273-plz1ja2e 344 59 cell cell NN cord-001273-plz1ja2e 344 60 accessible accessible JJ cord-001273-plz1ja2e 344 61 E e NN cord-001273-plz1ja2e 344 62 - - NN cord-001273-plz1ja2e 344 63 cadherin cadherin JJ cord-001273-plz1ja2e 344 64 Type type NN cord-001273-plz1ja2e 345 1 I -PRON- PRP cord-001273-plz1ja2e 346 1 interferon interferon NN cord-001273-plz1ja2e 346 2 production production NN cord-001273-plz1ja2e 346 3 enhances enhance VBZ cord-001273-plz1ja2e 346 4 susceptibility susceptibility NN cord-001273-plz1ja2e 346 5 to to IN cord-001273-plz1ja2e 346 6 Listeria Listeria NNP cord-001273-plz1ja2e 346 7 monocytogenes monocytogene NNS cord-001273-plz1ja2e 346 8 infection infection NN cord-001273-plz1ja2e 346 9 Immune immune JJ cord-001273-plz1ja2e 346 10 activation activation NN cord-001273-plz1ja2e 346 11 of of IN cord-001273-plz1ja2e 346 12 type type NN cord-001273-plz1ja2e 347 1 I -PRON- PRP cord-001273-plz1ja2e 347 2 IFNs ifns VBP cord-001273-plz1ja2e 347 3 by by IN cord-001273-plz1ja2e 347 4 Listeria Listeria NNP cord-001273-plz1ja2e 347 5 monocytogenes monocytogene NNS cord-001273-plz1ja2e 347 6 occurs occur VBZ cord-001273-plz1ja2e 347 7 independently independently RB cord-001273-plz1ja2e 347 8 of of IN cord-001273-plz1ja2e 347 9 TLR4 TLR4 NNP cord-001273-plz1ja2e 347 10 , , , cord-001273-plz1ja2e 347 11 TLR2 TLR2 NNP cord-001273-plz1ja2e 347 12 , , , cord-001273-plz1ja2e 347 13 and and CC cord-001273-plz1ja2e 347 14 receptor receptor NN cord-001273-plz1ja2e 347 15 interacting interact VBG cord-001273-plz1ja2e 347 16 protein protein NN cord-001273-plz1ja2e 347 17 2 2 CD cord-001273-plz1ja2e 347 18 but but CC cord-001273-plz1ja2e 347 19 involves involve VBZ cord-001273-plz1ja2e 347 20 TNFR TNFR NNP cord-001273-plz1ja2e 347 21 - - HYPH cord-001273-plz1ja2e 347 22 associated associate VBN cord-001273-plz1ja2e 347 23 NF NF NNP cord-001273-plz1ja2e 347 24 kappa kappa NN cord-001273-plz1ja2e 347 25 B B NNP cord-001273-plz1ja2e 347 26 kinase kinase NN cord-001273-plz1ja2e 347 27 - - HYPH cord-001273-plz1ja2e 347 28 binding bind VBG cord-001273-plz1ja2e 347 29 kinase kinase NN cord-001273-plz1ja2e 347 30 1 1 CD cord-001273-plz1ja2e 347 31 Host host NN cord-001273-plz1ja2e 347 32 defense defense NN cord-001273-plz1ja2e 347 33 and and CC cord-001273-plz1ja2e 347 34 endogenous endogenous JJ cord-001273-plz1ja2e 347 35 interferon interferon NN cord-001273-plz1ja2e 347 36 - - HYPH cord-001273-plz1ja2e 347 37 gamma gamma NN cord-001273-plz1ja2e 347 38 in in IN cord-001273-plz1ja2e 347 39 the the DT cord-001273-plz1ja2e 347 40 intestines intestine NNS cord-001273-plz1ja2e 347 41 during during IN cord-001273-plz1ja2e 347 42 an an DT cord-001273-plz1ja2e 347 43 oral oral JJ cord-001273-plz1ja2e 347 44 infection infection NN cord-001273-plz1ja2e 347 45 with with IN cord-001273-plz1ja2e 347 46 Listeria Listeria NNP cord-001273-plz1ja2e 347 47 monocytogenes monocytogene NNS cord-001273-plz1ja2e 347 48 Gastroenteritis Gastroenteritis NNP cord-001273-plz1ja2e 347 49 due due JJ cord-001273-plz1ja2e 347 50 to to IN cord-001273-plz1ja2e 347 51 Listeria Listeria NNP cord-001273-plz1ja2e 347 52 monocytogenes monocytogene NNS cord-001273-plz1ja2e 347 53 Innate innate JJ cord-001273-plz1ja2e 347 54 recognition recognition NN cord-001273-plz1ja2e 347 55 of of IN cord-001273-plz1ja2e 347 56 bacteria bacteria NNS cord-001273-plz1ja2e 347 57 by by IN cord-001273-plz1ja2e 347 58 a a DT cord-001273-plz1ja2e 347 59 macrophage macrophage NN cord-001273-plz1ja2e 347 60 cytosolic cytosolic JJ cord-001273-plz1ja2e 347 61 surveillance surveillance NN cord-001273-plz1ja2e 347 62 pathway pathway NN cord-001273-plz1ja2e 348 1 The the DT cord-001273-plz1ja2e 348 2 enhanceosome enhanceosome NN cord-001273-plz1ja2e 349 1 An an DT cord-001273-plz1ja2e 349 2 atomic atomic JJ cord-001273-plz1ja2e 349 3 model model NN cord-001273-plz1ja2e 349 4 of of IN cord-001273-plz1ja2e 349 5 the the DT cord-001273-plz1ja2e 349 6 interferon interferon NN cord-001273-plz1ja2e 349 7 - - HYPH cord-001273-plz1ja2e 349 8 beta beta NN cord-001273-plz1ja2e 349 9 enhanceosome enhanceosome NN cord-001273-plz1ja2e 350 1 The the DT cord-001273-plz1ja2e 350 2 helicase helicase NN cord-001273-plz1ja2e 350 3 DDX41 DDX41 NNP cord-001273-plz1ja2e 350 4 recognizes recognize VBZ cord-001273-plz1ja2e 350 5 the the DT cord-001273-plz1ja2e 350 6 bacterial bacterial JJ cord-001273-plz1ja2e 350 7 secondary secondary JJ cord-001273-plz1ja2e 350 8 messengers messenger NNS cord-001273-plz1ja2e 350 9 cyclic cyclic JJ cord-001273-plz1ja2e 350 10 di di FW cord-001273-plz1ja2e 350 11 - - HYPH cord-001273-plz1ja2e 350 12 GMP GMP NNP cord-001273-plz1ja2e 350 13 and and CC cord-001273-plz1ja2e 350 14 cyclic cyclic JJ cord-001273-plz1ja2e 350 15 di di FW cord-001273-plz1ja2e 350 16 - - HYPH cord-001273-plz1ja2e 350 17 AMP AMP NNP cord-001273-plz1ja2e 350 18 to to TO cord-001273-plz1ja2e 350 19 activate activate VB cord-001273-plz1ja2e 350 20 a a DT cord-001273-plz1ja2e 350 21 type type NN cord-001273-plz1ja2e 351 1 I -PRON- PRP cord-001273-plz1ja2e 351 2 interferon interferon VBP cord-001273-plz1ja2e 351 3 immune immune VBP cord-001273-plz1ja2e 351 4 response response NN cord-001273-plz1ja2e 352 1 Opposing oppose VBG cord-001273-plz1ja2e 352 2 roles role NNS cord-001273-plz1ja2e 352 3 for for IN cord-001273-plz1ja2e 352 4 interferon interferon NN cord-001273-plz1ja2e 352 5 regulatory regulatory JJ cord-001273-plz1ja2e 352 6 factor-3 factor-3 NNP cord-001273-plz1ja2e 352 7 ( ( -LRB- cord-001273-plz1ja2e 352 8 IRF-3 IRF-3 NNP cord-001273-plz1ja2e 352 9 ) ) -RRB- cord-001273-plz1ja2e 352 10 and and CC cord-001273-plz1ja2e 352 11 type type NN cord-001273-plz1ja2e 352 12 I -PRON- PRP cord-001273-plz1ja2e 352 13 interferon interferon NN cord-001273-plz1ja2e 352 14 signaling signal VBG cord-001273-plz1ja2e 352 15 during during IN cord-001273-plz1ja2e 352 16 plague plague NN cord-001273-plz1ja2e 352 17 Listeria Listeria NNP cord-001273-plz1ja2e 352 18 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 352 19 invades invade VBZ cord-001273-plz1ja2e 352 20 the the DT cord-001273-plz1ja2e 352 21 epithelial epithelial JJ cord-001273-plz1ja2e 352 22 junctions junction NNS cord-001273-plz1ja2e 352 23 at at IN cord-001273-plz1ja2e 352 24 sites site NNS cord-001273-plz1ja2e 352 25 of of IN cord-001273-plz1ja2e 352 26 cell cell NN cord-001273-plz1ja2e 352 27 extrusion extrusion NN cord-001273-plz1ja2e 353 1 The the DT cord-001273-plz1ja2e 353 2 stress stress NN cord-001273-plz1ja2e 353 3 - - HYPH cord-001273-plz1ja2e 353 4 induced induce VBN cord-001273-plz1ja2e 353 5 virulence virulence NN cord-001273-plz1ja2e 353 6 protein protein NN cord-001273-plz1ja2e 353 7 InlH InlH NNP cord-001273-plz1ja2e 353 8 controls control VBZ cord-001273-plz1ja2e 353 9 interleukin-6 interleukin-6 NNP cord-001273-plz1ja2e 353 10 production production NN cord-001273-plz1ja2e 353 11 during during IN cord-001273-plz1ja2e 353 12 murine murine JJ cord-001273-plz1ja2e 353 13 listeriosis listeriosis NN cord-001273-plz1ja2e 354 1 The the DT cord-001273-plz1ja2e 354 2 interferons interferon NNS cord-001273-plz1ja2e 354 3 : : : cord-001273-plz1ja2e 354 4 50 50 CD cord-001273-plz1ja2e 354 5 years year NNS cord-001273-plz1ja2e 354 6 after after IN cord-001273-plz1ja2e 354 7 their -PRON- PRP$ cord-001273-plz1ja2e 354 8 discovery discovery NN cord-001273-plz1ja2e 354 9 , , , cord-001273-plz1ja2e 354 10 there there EX cord-001273-plz1ja2e 354 11 is be VBZ cord-001273-plz1ja2e 354 12 much much RB cord-001273-plz1ja2e 354 13 more more JJR cord-001273-plz1ja2e 354 14 to to TO cord-001273-plz1ja2e 354 15 learn learn VB cord-001273-plz1ja2e 354 16 Interferons Interferons NNP cord-001273-plz1ja2e 354 17 , , , cord-001273-plz1ja2e 354 18 interferon interferon NN cord-001273-plz1ja2e 354 19 - - HYPH cord-001273-plz1ja2e 354 20 like like JJ cord-001273-plz1ja2e 354 21 cytokines cytokine NNS cord-001273-plz1ja2e 354 22 , , , cord-001273-plz1ja2e 354 23 and and CC cord-001273-plz1ja2e 354 24 their -PRON- PRP$ cord-001273-plz1ja2e 354 25 receptors receptor NNS cord-001273-plz1ja2e 354 26 Structural structural JJ cord-001273-plz1ja2e 354 27 and and CC cord-001273-plz1ja2e 354 28 dynamic dynamic JJ cord-001273-plz1ja2e 354 29 determinants determinant NNS cord-001273-plz1ja2e 354 30 of of IN cord-001273-plz1ja2e 354 31 type type NN cord-001273-plz1ja2e 355 1 I -PRON- PRP cord-001273-plz1ja2e 355 2 interferon interferon VBD cord-001273-plz1ja2e 355 3 receptor receptor NN cord-001273-plz1ja2e 355 4 assembly assembly NN cord-001273-plz1ja2e 355 5 and and CC cord-001273-plz1ja2e 355 6 their -PRON- PRP$ cord-001273-plz1ja2e 355 7 functional functional JJ cord-001273-plz1ja2e 355 8 interpretation interpretation NN cord-001273-plz1ja2e 355 9 Inhibition inhibition NN cord-001273-plz1ja2e 355 10 of of IN cord-001273-plz1ja2e 355 11 dynamin dynamin NN cord-001273-plz1ja2e 355 12 - - HYPH cord-001273-plz1ja2e 355 13 dependent dependent JJ cord-001273-plz1ja2e 355 14 endocytosis endocytosis NN cord-001273-plz1ja2e 355 15 interferes interfere VBZ cord-001273-plz1ja2e 355 16 with with IN cord-001273-plz1ja2e 355 17 type type NN cord-001273-plz1ja2e 355 18 III III NNP cord-001273-plz1ja2e 355 19 IFN IFN NNP cord-001273-plz1ja2e 355 20 expression expression NN cord-001273-plz1ja2e 355 21 in in IN cord-001273-plz1ja2e 355 22 bacteria bacteria NNS cord-001273-plz1ja2e 355 23 - - HYPH cord-001273-plz1ja2e 355 24 infected infect VBN cord-001273-plz1ja2e 355 25 human human JJ cord-001273-plz1ja2e 355 26 monocyte monocyte NN cord-001273-plz1ja2e 355 27 - - HYPH cord-001273-plz1ja2e 355 28 derived derive VBN cord-001273-plz1ja2e 355 29 DCs dc NNS cord-001273-plz1ja2e 356 1 The the DT cord-001273-plz1ja2e 356 2 timing timing NN cord-001273-plz1ja2e 356 3 of of IN cord-001273-plz1ja2e 356 4 IFNβ IFNβ NNS cord-001273-plz1ja2e 356 5 production production NN cord-001273-plz1ja2e 356 6 affects affect VBZ cord-001273-plz1ja2e 356 7 early early JJ cord-001273-plz1ja2e 356 8 innate innate JJ cord-001273-plz1ja2e 356 9 responses response NNS cord-001273-plz1ja2e 356 10 to to IN cord-001273-plz1ja2e 356 11 Listeria Listeria NNP cord-001273-plz1ja2e 356 12 monocytogenes monocytogene NNS cord-001273-plz1ja2e 356 13 and and CC cord-001273-plz1ja2e 356 14 determines determine VBZ cord-001273-plz1ja2e 356 15 the the DT cord-001273-plz1ja2e 356 16 overall overall JJ cord-001273-plz1ja2e 356 17 outcome outcome NN cord-001273-plz1ja2e 356 18 of of IN cord-001273-plz1ja2e 356 19 lethal lethal JJ cord-001273-plz1ja2e 356 20 infection infection NN cord-001273-plz1ja2e 356 21 Indoleamine Indoleamine NNP cord-001273-plz1ja2e 356 22 2,3-dioxygenase 2,3-dioxygenase NNP cord-001273-plz1ja2e 356 23 - - HYPH cord-001273-plz1ja2e 356 24 expressing express VBG cord-001273-plz1ja2e 356 25 dendritic dendritic JJ cord-001273-plz1ja2e 356 26 cells cell NNS cord-001273-plz1ja2e 356 27 form form VBP cord-001273-plz1ja2e 356 28 suppurative suppurative JJ cord-001273-plz1ja2e 356 29 granulomas granuloma NNS cord-001273-plz1ja2e 356 30 following follow VBG cord-001273-plz1ja2e 356 31 Listeria Listeria NNP cord-001273-plz1ja2e 356 32 monocytogenes monocytogene NNS cord-001273-plz1ja2e 356 33 infection infection NN cord-001273-plz1ja2e 357 1 A a DT cord-001273-plz1ja2e 357 2 variant variant NN cord-001273-plz1ja2e 357 3 upstream upstream NN cord-001273-plz1ja2e 357 4 of of IN cord-001273-plz1ja2e 357 5 IFNL3 ifnl3 XX cord-001273-plz1ja2e 358 1 ( ( -LRB- cord-001273-plz1ja2e 358 2 IL28B il28b NN cord-001273-plz1ja2e 358 3 ) ) -RRB- cord-001273-plz1ja2e 358 4 creating create VBG cord-001273-plz1ja2e 358 5 a a DT cord-001273-plz1ja2e 358 6 new new JJ cord-001273-plz1ja2e 358 7 interferon interferon NN cord-001273-plz1ja2e 358 8 gene gene NN cord-001273-plz1ja2e 358 9 IFNL4 IFNL4 NNP cord-001273-plz1ja2e 358 10 is be VBZ cord-001273-plz1ja2e 358 11 associated associate VBN cord-001273-plz1ja2e 358 12 with with IN cord-001273-plz1ja2e 358 13 impaired impaired JJ cord-001273-plz1ja2e 358 14 clearance clearance NN cord-001273-plz1ja2e 358 15 of of IN cord-001273-plz1ja2e 358 16 hepatitis hepatitis NN cord-001273-plz1ja2e 358 17 C C NNP cord-001273-plz1ja2e 358 18 virus virus NN cord-001273-plz1ja2e 358 19 Type type NN cord-001273-plz1ja2e 358 20 I -PRON- PRP cord-001273-plz1ja2e 358 21 IFNs ifns VBP cord-001273-plz1ja2e 358 22 enhance enhance VB cord-001273-plz1ja2e 358 23 susceptibility susceptibility NN cord-001273-plz1ja2e 358 24 to to IN cord-001273-plz1ja2e 358 25 Chlamydia Chlamydia NNP cord-001273-plz1ja2e 358 26 muridarum muridarum NN cord-001273-plz1ja2e 358 27 lung lung NN cord-001273-plz1ja2e 358 28 infection infection NN cord-001273-plz1ja2e 358 29 by by IN cord-001273-plz1ja2e 358 30 enhancing enhance VBG cord-001273-plz1ja2e 358 31 apoptosis apoptosis NN cord-001273-plz1ja2e 358 32 of of IN cord-001273-plz1ja2e 358 33 local local JJ cord-001273-plz1ja2e 358 34 macrophages macrophage NNS cord-001273-plz1ja2e 358 35 Mutations mutation NNS cord-001273-plz1ja2e 358 36 of of IN cord-001273-plz1ja2e 358 37 the the DT cord-001273-plz1ja2e 358 38 Listeria Listeria NNP cord-001273-plz1ja2e 358 39 monocytogenes monocytogene NNS cord-001273-plz1ja2e 358 40 peptidoglycan peptidoglycan NNP cord-001273-plz1ja2e 358 41 N N NNP cord-001273-plz1ja2e 358 42 - - HYPH cord-001273-plz1ja2e 358 43 deacetylase deacetylase NNP cord-001273-plz1ja2e 358 44 and and CC cord-001273-plz1ja2e 358 45 O o NN cord-001273-plz1ja2e 358 46 - - HYPH cord-001273-plz1ja2e 358 47 acetylase acetylase JJ cord-001273-plz1ja2e 358 48 result result NN cord-001273-plz1ja2e 358 49 in in IN cord-001273-plz1ja2e 358 50 enhanced enhanced JJ cord-001273-plz1ja2e 358 51 lysozyme lysozyme NNS cord-001273-plz1ja2e 358 52 sensitivity sensitivity NN cord-001273-plz1ja2e 358 53 , , , cord-001273-plz1ja2e 358 54 bacteriolysis bacteriolysis NNP cord-001273-plz1ja2e 358 55 , , , cord-001273-plz1ja2e 358 56 and and CC cord-001273-plz1ja2e 358 57 hyperinduction hyperinduction NN cord-001273-plz1ja2e 358 58 of of IN cord-001273-plz1ja2e 358 59 innate innate JJ cord-001273-plz1ja2e 358 60 immune immune JJ cord-001273-plz1ja2e 358 61 pathways pathway NNS cord-001273-plz1ja2e 358 62 Antagonistic antagonistic JJ cord-001273-plz1ja2e 358 63 crosstalk crosstalk NN cord-001273-plz1ja2e 358 64 between between IN cord-001273-plz1ja2e 358 65 type type NN cord-001273-plz1ja2e 358 66 I i NN cord-001273-plz1ja2e 358 67 and and CC cord-001273-plz1ja2e 358 68 II II NNP cord-001273-plz1ja2e 358 69 interferons interferon NNS cord-001273-plz1ja2e 358 70 and and CC cord-001273-plz1ja2e 358 71 increased increase VBN cord-001273-plz1ja2e 358 72 host host NN cord-001273-plz1ja2e 358 73 susceptibility susceptibility NN cord-001273-plz1ja2e 358 74 to to IN cord-001273-plz1ja2e 358 75 bacterial bacterial JJ cord-001273-plz1ja2e 358 76 infections infection NNS cord-001273-plz1ja2e 358 77 Type type NN cord-001273-plz1ja2e 359 1 I -PRON- PRP cord-001273-plz1ja2e 359 2 IFN IFN NNP cord-001273-plz1ja2e 359 3 are be VBP cord-001273-plz1ja2e 359 4 host host NN cord-001273-plz1ja2e 359 5 modulators modulator NNS cord-001273-plz1ja2e 359 6 of of IN cord-001273-plz1ja2e 359 7 strain strain NN cord-001273-plz1ja2e 359 8 - - HYPH cord-001273-plz1ja2e 359 9 specific specific JJ cord-001273-plz1ja2e 359 10 Listeria Listeria NNP cord-001273-plz1ja2e 359 11 monocytogenes monocytogenes NN cord-001273-plz1ja2e 359 12 virulence virulence NN cord-001273-plz1ja2e 359 13 Identity identity NN cord-001273-plz1ja2e 359 14 , , , cord-001273-plz1ja2e 359 15 regulation regulation NN cord-001273-plz1ja2e 359 16 and and CC cord-001273-plz1ja2e 359 17 in in IN cord-001273-plz1ja2e 359 18 vivo vivo NN cord-001273-plz1ja2e 359 19 function function NN cord-001273-plz1ja2e 359 20 of of IN cord-001273-plz1ja2e 359 21 gut gut NN cord-001273-plz1ja2e 359 22 NKp46(+)RORγt(+ NKp46(+)RORγt(+ NNS cord-001273-plz1ja2e 359 23 ) ) -RRB- cord-001273-plz1ja2e 359 24 and and CC cord-001273-plz1ja2e 360 1 NKp46(+)RORγt(- NKp46(+)RORγt(- NNP cord-001273-plz1ja2e 360 2 ) ) -RRB- cord-001273-plz1ja2e 360 3 lymphoid lymphoid JJ cord-001273-plz1ja2e 360 4 cells cell NNS cord-001273-plz1ja2e 360 5 Type type NN cord-001273-plz1ja2e 361 1 I -PRON- PRP cord-001273-plz1ja2e 361 2 interferon interferon RB cord-001273-plz1ja2e 361 3 induces induce VBZ cord-001273-plz1ja2e 361 4 necroptosis necroptosis NNP cord-001273-plz1ja2e 361 5 in in IN cord-001273-plz1ja2e 361 6 macrophages macrophage NNS cord-001273-plz1ja2e 361 7 during during IN cord-001273-plz1ja2e 361 8 infection infection NN cord-001273-plz1ja2e 361 9 with with IN cord-001273-plz1ja2e 361 10 Salmonella Salmonella NNP cord-001273-plz1ja2e 361 11 enterica enterica NNP cord-001273-plz1ja2e 362 1 serovar serovar NNP cord-001273-plz1ja2e 362 2 Typhimurium Typhimurium NNP cord-001273-plz1ja2e 362 3 Listeria Listeria NNP cord-001273-plz1ja2e 362 4 monocytogenes monocytogene NNS cord-001273-plz1ja2e 362 5 and and CC cord-001273-plz1ja2e 362 6 recurrent recurrent JJ cord-001273-plz1ja2e 362 7 mycobacterial mycobacterial JJ cord-001273-plz1ja2e 362 8 infections infection NNS cord-001273-plz1ja2e 362 9 in in IN cord-001273-plz1ja2e 362 10 a a DT cord-001273-plz1ja2e 362 11 child child NN cord-001273-plz1ja2e 362 12 with with IN cord-001273-plz1ja2e 362 13 complete complete JJ cord-001273-plz1ja2e 362 14 interferon interferon NN cord-001273-plz1ja2e 362 15 - - HYPH cord-001273-plz1ja2e 362 16 gamma gamma NN cord-001273-plz1ja2e 362 17 - - HYPH cord-001273-plz1ja2e 362 18 receptor receptor NN cord-001273-plz1ja2e 362 19 ( ( -LRB- cord-001273-plz1ja2e 362 20 IFNgammaR1 IFNgammaR1 NNP cord-001273-plz1ja2e 362 21 ) ) -RRB- cord-001273-plz1ja2e 362 22 deficiency deficiency NN cord-001273-plz1ja2e 362 23 : : : cord-001273-plz1ja2e 362 24 mutational mutational JJ cord-001273-plz1ja2e 362 25 analysis analysis NN cord-001273-plz1ja2e 362 26 and and CC cord-001273-plz1ja2e 362 27 evaluation evaluation NN cord-001273-plz1ja2e 362 28 of of IN cord-001273-plz1ja2e 362 29 therapeutic therapeutic JJ cord-001273-plz1ja2e 362 30 options option NNS cord-001273-plz1ja2e 362 31 Interferome Interferome NNP cord-001273-plz1ja2e 363 1 v2.0 v2.0 NNP cord-001273-plz1ja2e 363 2 : : : cord-001273-plz1ja2e 364 1 an an DT cord-001273-plz1ja2e 364 2 updated update VBN cord-001273-plz1ja2e 364 3 database database NN cord-001273-plz1ja2e 364 4 of of IN cord-001273-plz1ja2e 364 5 annotated annotate VBN cord-001273-plz1ja2e 364 6 interferon interferon NN cord-001273-plz1ja2e 364 7 - - HYPH cord-001273-plz1ja2e 364 8 regulated regulate VBN cord-001273-plz1ja2e 364 9 genes gene NNS cord-001273-plz1ja2e 364 10 CREB CREB NNP cord-001273-plz1ja2e 364 11 , , , cord-001273-plz1ja2e 364 12 ATF ATF NNP cord-001273-plz1ja2e 364 13 , , , cord-001273-plz1ja2e 364 14 and and CC cord-001273-plz1ja2e 365 1 AP-1 AP-1 NNP cord-001273-plz1ja2e 365 2 transcription transcription NN cord-001273-plz1ja2e 365 3 factors factor NNS cord-001273-plz1ja2e 365 4 regulate regulate VBP cord-001273-plz1ja2e 365 5 IFN IFN NNP cord-001273-plz1ja2e 365 6 - - HYPH cord-001273-plz1ja2e 365 7 gamma gamma NN cord-001273-plz1ja2e 365 8 secretion secretion NN cord-001273-plz1ja2e 365 9 by by IN cord-001273-plz1ja2e 365 10 human human JJ cord-001273-plz1ja2e 365 11 T t NN cord-001273-plz1ja2e 365 12 cells cell NNS cord-001273-plz1ja2e 365 13 in in IN cord-001273-plz1ja2e 365 14 response response NN cord-001273-plz1ja2e 365 15 to to IN cord-001273-plz1ja2e 365 16 mycobacterial mycobacterial NNP cord-001273-plz1ja2e 365 17 antigen antigen NNP cord-001273-plz1ja2e 365 18 The the DT cord-001273-plz1ja2e 365 19 ENU ENU NNP cord-001273-plz1ja2e 365 20 - - HYPH cord-001273-plz1ja2e 365 21 induced induce VBN cord-001273-plz1ja2e 365 22 Goldenticket Goldenticket NNP cord-001273-plz1ja2e 365 23 mouse mouse NN cord-001273-plz1ja2e 365 24 mutant mutant NN cord-001273-plz1ja2e 365 25 reveals reveal VBZ cord-001273-plz1ja2e 365 26 an an DT cord-001273-plz1ja2e 365 27 essential essential JJ cord-001273-plz1ja2e 365 28 function function NN cord-001273-plz1ja2e 365 29 of of IN cord-001273-plz1ja2e 365 30 Sting Sting NNP cord-001273-plz1ja2e 365 31 in in IN cord-001273-plz1ja2e 365 32 the the DT cord-001273-plz1ja2e 365 33 in in IN cord-001273-plz1ja2e 365 34 vivo vivo FW cord-001273-plz1ja2e 365 35 interferon interferon NN cord-001273-plz1ja2e 365 36 response response NN cord-001273-plz1ja2e 365 37 to to IN cord-001273-plz1ja2e 365 38 Listeria Listeria NNP cord-001273-plz1ja2e 365 39 monocytogenes monocytogene NNS cord-001273-plz1ja2e 365 40 and and CC cord-001273-plz1ja2e 365 41 cyclic cyclic JJ cord-001273-plz1ja2e 365 42 - - HYPH cord-001273-plz1ja2e 365 43 di di NN cord-001273-plz1ja2e 365 44 - - HYPH cord-001273-plz1ja2e 365 45 nucleotides nucleotides JJ cord-001273-plz1ja2e 365 46 JAK JAK NNP cord-001273-plz1ja2e 365 47 - - HYPH cord-001273-plz1ja2e 365 48 STAT STAT NNP cord-001273-plz1ja2e 365 49 signaling signaling NN cord-001273-plz1ja2e 365 50 : : : cord-001273-plz1ja2e 365 51 from from IN cord-001273-plz1ja2e 365 52 interferons interferon NNS cord-001273-plz1ja2e 365 53 to to IN cord-001273-plz1ja2e 365 54 cytokines cytokine NNS cord-001273-plz1ja2e 365 55 Epidemic epidemic NN cord-001273-plz1ja2e 365 56 listeriosis listeriosis NN cord-001273-plz1ja2e 365 57 : : : cord-001273-plz1ja2e 365 58 evidence evidence NN cord-001273-plz1ja2e 365 59 for for IN cord-001273-plz1ja2e 365 60 transmission transmission NN cord-001273-plz1ja2e 365 61 by by IN cord-001273-plz1ja2e 365 62 food food NN cord-001273-plz1ja2e 365 63 Regulation regulation NN cord-001273-plz1ja2e 365 64 of of IN cord-001273-plz1ja2e 365 65 interferon interferon NN cord-001273-plz1ja2e 365 66 - - HYPH cord-001273-plz1ja2e 365 67 γ γ NN cord-001273-plz1ja2e 365 68 during during IN cord-001273-plz1ja2e 365 69 innate innate JJ cord-001273-plz1ja2e 365 70 and and CC cord-001273-plz1ja2e 365 71 adaptive adaptive JJ cord-001273-plz1ja2e 365 72 immune immune JJ cord-001273-plz1ja2e 365 73 responses response NNS cord-001273-plz1ja2e 366 1 Pan pan JJ cord-001273-plz1ja2e 366 2 - - JJ cord-001273-plz1ja2e 366 3 viral viral JJ cord-001273-plz1ja2e 366 4 specificity specificity NN cord-001273-plz1ja2e 366 5 of of IN cord-001273-plz1ja2e 366 6 IFN IFN NNP cord-001273-plz1ja2e 366 7 - - HYPH cord-001273-plz1ja2e 366 8 induced induce VBN cord-001273-plz1ja2e 366 9 genes gene NNS cord-001273-plz1ja2e 366 10 reveals reveal VBZ cord-001273-plz1ja2e 366 11 new new JJ cord-001273-plz1ja2e 366 12 roles role NNS cord-001273-plz1ja2e 366 13 for for IN cord-001273-plz1ja2e 366 14 cGAS cgas NN cord-001273-plz1ja2e 366 15 in in IN cord-001273-plz1ja2e 366 16 innate innate JJ cord-001273-plz1ja2e 366 17 immunity immunity NN cord-001273-plz1ja2e 366 18 A a DT cord-001273-plz1ja2e 366 19 diverse diverse JJ cord-001273-plz1ja2e 366 20 range range NN cord-001273-plz1ja2e 366 21 of of IN cord-001273-plz1ja2e 366 22 gene gene NN cord-001273-plz1ja2e 366 23 products product NNS cord-001273-plz1ja2e 366 24 are be VBP cord-001273-plz1ja2e 366 25 effectors effector NNS cord-001273-plz1ja2e 366 26 of of IN cord-001273-plz1ja2e 366 27 the the DT cord-001273-plz1ja2e 366 28 type type NN cord-001273-plz1ja2e 367 1 I -PRON- PRP cord-001273-plz1ja2e 367 2 interferon interferon VBP cord-001273-plz1ja2e 367 3 antiviral antiviral JJ cord-001273-plz1ja2e 367 4 response response NN cord-001273-plz1ja2e 368 1 Interferon interferon NN cord-001273-plz1ja2e 368 2 - - HYPH cord-001273-plz1ja2e 368 3 gamma gamma NN cord-001273-plz1ja2e 368 4 : : : cord-001273-plz1ja2e 368 5 an an DT cord-001273-plz1ja2e 368 6 overview overview NN cord-001273-plz1ja2e 368 7 of of IN cord-001273-plz1ja2e 368 8 signals signal NNS cord-001273-plz1ja2e 368 9 , , , cord-001273-plz1ja2e 368 10 mechanisms mechanism NNS cord-001273-plz1ja2e 368 11 and and CC cord-001273-plz1ja2e 368 12 functions function NNS cord-001273-plz1ja2e 368 13 Hyperinduction Hyperinduction NNP cord-001273-plz1ja2e 368 14 of of IN cord-001273-plz1ja2e 368 15 host host NN cord-001273-plz1ja2e 369 1 beta beta NN cord-001273-plz1ja2e 369 2 interferon interferon NN cord-001273-plz1ja2e 369 3 by by IN cord-001273-plz1ja2e 369 4 a a DT cord-001273-plz1ja2e 369 5 Listeria Listeria NNP cord-001273-plz1ja2e 369 6 monocytogenes monocytogene NNS cord-001273-plz1ja2e 369 7 strain strain VBP cord-001273-plz1ja2e 369 8 naturally naturally RB cord-001273-plz1ja2e 369 9 overexpressing overexpresse VBG cord-001273-plz1ja2e 370 1 the the DT cord-001273-plz1ja2e 370 2 multidrug multidrug NN cord-001273-plz1ja2e 370 3 efflux efflux NN cord-001273-plz1ja2e 370 4 pump pump NN cord-001273-plz1ja2e 371 1 MdrT MdrT NNP cord-001273-plz1ja2e 372 1 The the DT cord-001273-plz1ja2e 372 2 role role NN cord-001273-plz1ja2e 372 3 of of IN cord-001273-plz1ja2e 372 4 the the DT cord-001273-plz1ja2e 372 5 activated activate VBN cord-001273-plz1ja2e 372 6 macrophage macrophage NN cord-001273-plz1ja2e 372 7 in in IN cord-001273-plz1ja2e 372 8 clearing clear VBG cord-001273-plz1ja2e 372 9 Listeria Listeria NNP cord-001273-plz1ja2e 372 10 monocytogenes monocytogene NNS cord-001273-plz1ja2e 372 11 infection infection NN cord-001273-plz1ja2e 372 12 IL-28 IL-28 NNP cord-001273-plz1ja2e 372 13 , , , cord-001273-plz1ja2e 372 14 IL-29 IL-29 NNP cord-001273-plz1ja2e 372 15 and and CC cord-001273-plz1ja2e 372 16 their -PRON- PRP$ cord-001273-plz1ja2e 372 17 class class NN cord-001273-plz1ja2e 372 18 II ii CD cord-001273-plz1ja2e 372 19 cytokine cytokine NN cord-001273-plz1ja2e 372 20 receptor receptor NN cord-001273-plz1ja2e 372 21 IL-28R il-28r IN cord-001273-plz1ja2e 372 22 Monocyte Monocyte NNP cord-001273-plz1ja2e 372 23 recruitment recruitment NN cord-001273-plz1ja2e 372 24 during during IN cord-001273-plz1ja2e 372 25 infection infection NN cord-001273-plz1ja2e 372 26 and and CC cord-001273-plz1ja2e 372 27 inflammation inflammation NN cord-001273-plz1ja2e 372 28 Nuclear nuclear JJ cord-001273-plz1ja2e 372 29 receptor receptor NN cord-001273-plz1ja2e 372 30 ERR err NN cord-001273-plz1ja2e 372 31 - - HYPH cord-001273-plz1ja2e 372 32 alpha alpha NN cord-001273-plz1ja2e 372 33 and and CC cord-001273-plz1ja2e 372 34 coactivator coactivator NN cord-001273-plz1ja2e 373 1 PGC-1beta pgc-1beta NN cord-001273-plz1ja2e 373 2 are be VBP cord-001273-plz1ja2e 373 3 effectors effector NNS cord-001273-plz1ja2e 373 4 of of IN cord-001273-plz1ja2e 373 5 IFN IFN NNP cord-001273-plz1ja2e 373 6 - - HYPH cord-001273-plz1ja2e 373 7 gamma gamma NN cord-001273-plz1ja2e 373 8 - - HYPH cord-001273-plz1ja2e 373 9 induced induce VBN cord-001273-plz1ja2e 373 10 host host NN cord-001273-plz1ja2e 373 11 defense defense NN cord-001273-plz1ja2e 373 12 Cell cell NN cord-001273-plz1ja2e 373 13 biology biology NN cord-001273-plz1ja2e 373 14 and and CC cord-001273-plz1ja2e 373 15 immunology immunology NN cord-001273-plz1ja2e 373 16 of of IN cord-001273-plz1ja2e 373 17 Listeria Listeria NNP cord-001273-plz1ja2e 373 18 monocytogenes monocytogenes NN cord-001273-plz1ja2e 373 19 infections infection NNS cord-001273-plz1ja2e 373 20 : : : cord-001273-plz1ja2e 374 1 novel novel JJ cord-001273-plz1ja2e 374 2 insights insight NNS cord-001273-plz1ja2e 374 3 Type Type NNP cord-001273-plz1ja2e 375 1 I -PRON- PRP cord-001273-plz1ja2e 375 2 interferons interferon NNS cord-001273-plz1ja2e 375 3 in in IN cord-001273-plz1ja2e 375 4 host host NN cord-001273-plz1ja2e 375 5 defense defense NN cord-001273-plz1ja2e 375 6 Characterization characterization NN cord-001273-plz1ja2e 375 7 of of IN cord-001273-plz1ja2e 375 8 the the DT cord-001273-plz1ja2e 375 9 interferon interferon NN cord-001273-plz1ja2e 375 10 - - HYPH cord-001273-plz1ja2e 375 11 producing produce VBG cord-001273-plz1ja2e 375 12 cell cell NN cord-001273-plz1ja2e 375 13 in in IN cord-001273-plz1ja2e 375 14 mice mouse NNS cord-001273-plz1ja2e 375 15 infected infect VBN cord-001273-plz1ja2e 375 16 with with IN cord-001273-plz1ja2e 375 17 Listeria Listeria NNP cord-001273-plz1ja2e 375 18 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 375 19 IFN IFN NNP cord-001273-plz1ja2e 375 20 regulatory regulatory JJ cord-001273-plz1ja2e 375 21 factor factor NN cord-001273-plz1ja2e 375 22 3-dependent 3-dependent CD cord-001273-plz1ja2e 375 23 induction induction NN cord-001273-plz1ja2e 375 24 of of IN cord-001273-plz1ja2e 375 25 type type NN cord-001273-plz1ja2e 376 1 I -PRON- PRP cord-001273-plz1ja2e 376 2 IFNs ifns VBP cord-001273-plz1ja2e 376 3 by by IN cord-001273-plz1ja2e 376 4 intracellular intracellular JJ cord-001273-plz1ja2e 376 5 bacteria bacteria NNS cord-001273-plz1ja2e 376 6 is be VBZ cord-001273-plz1ja2e 376 7 mediated mediate VBN cord-001273-plz1ja2e 376 8 by by IN cord-001273-plz1ja2e 376 9 a a DT cord-001273-plz1ja2e 376 10 TLR TLR NNP cord-001273-plz1ja2e 376 11 - - : cord-001273-plz1ja2e 376 12 and and CC cord-001273-plz1ja2e 376 13 Nod2-independent Nod2-independent NNP cord-001273-plz1ja2e 376 14 mechanism mechanism NN cord-001273-plz1ja2e 377 1 Cyclic cyclic JJ cord-001273-plz1ja2e 377 2 GMP GMP NNP cord-001273-plz1ja2e 377 3 - - HYPH cord-001273-plz1ja2e 377 4 AMP AMP NNP cord-001273-plz1ja2e 377 5 synthase synthase NN cord-001273-plz1ja2e 377 6 is be VBZ cord-001273-plz1ja2e 377 7 a a DT cord-001273-plz1ja2e 377 8 cytosolic cytosolic JJ cord-001273-plz1ja2e 377 9 DNA dna NN cord-001273-plz1ja2e 377 10 sensor sensor NN cord-001273-plz1ja2e 377 11 that that WDT cord-001273-plz1ja2e 377 12 activates activate VBZ cord-001273-plz1ja2e 377 13 the the DT cord-001273-plz1ja2e 377 14 type type NN cord-001273-plz1ja2e 377 15 I -PRON- PRP cord-001273-plz1ja2e 377 16 interferon interferon VBD cord-001273-plz1ja2e 377 17 pathway pathway NN cord-001273-plz1ja2e 378 1 The the DT cord-001273-plz1ja2e 378 2 epidemiology epidemiology NN cord-001273-plz1ja2e 378 3 of of IN cord-001273-plz1ja2e 378 4 human human JJ cord-001273-plz1ja2e 378 5 listeriosis listeriosis NN cord-001273-plz1ja2e 378 6 . . . cord-001273-plz1ja2e 379 1 Microbes microbe NNS cord-001273-plz1ja2e 379 2 Infect infect VBP cord-001273-plz1ja2e 379 3 The the DT cord-001273-plz1ja2e 379 4 feedback feedback NN cord-001273-plz1ja2e 379 5 phase phase NN cord-001273-plz1ja2e 379 6 of of IN cord-001273-plz1ja2e 379 7 type type NN cord-001273-plz1ja2e 380 1 I -PRON- PRP cord-001273-plz1ja2e 381 1 interferon interferon NNP cord-001273-plz1ja2e 381 2 induction induction NN cord-001273-plz1ja2e 381 3 in in IN cord-001273-plz1ja2e 381 4 dendritic dendritic JJ cord-001273-plz1ja2e 381 5 cells cell NNS cord-001273-plz1ja2e 381 6 requires require VBZ cord-001273-plz1ja2e 381 7 interferon interferon NN cord-001273-plz1ja2e 381 8 regulatory regulatory JJ cord-001273-plz1ja2e 381 9 factor factor NN cord-001273-plz1ja2e 381 10 8 8 CD cord-001273-plz1ja2e 381 11 Sources source NNS cord-001273-plz1ja2e 381 12 of of IN cord-001273-plz1ja2e 381 13 interferon interferon NN cord-001273-plz1ja2e 381 14 - - HYPH cord-001273-plz1ja2e 381 15 gamma gamma NN cord-001273-plz1ja2e 381 16 in in IN cord-001273-plz1ja2e 381 17 early early JJ cord-001273-plz1ja2e 381 18 immune immune JJ cord-001273-plz1ja2e 381 19 response response NN cord-001273-plz1ja2e 381 20 to to IN cord-001273-plz1ja2e 381 21 Listeria Listeria NNP cord-001273-plz1ja2e 381 22 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 381 23 The the DT cord-001273-plz1ja2e 381 24 Listeria Listeria NNP cord-001273-plz1ja2e 381 25 transcriptional transcriptional JJ cord-001273-plz1ja2e 381 26 landscape landscape NN cord-001273-plz1ja2e 381 27 from from IN cord-001273-plz1ja2e 381 28 saprophytism saprophytism NN cord-001273-plz1ja2e 381 29 to to IN cord-001273-plz1ja2e 381 30 virulence virulence NN cord-001273-plz1ja2e 381 31 Type type NN cord-001273-plz1ja2e 382 1 I -PRON- PRP cord-001273-plz1ja2e 383 1 interferon interferon NN cord-001273-plz1ja2e 383 2 : : : cord-001273-plz1ja2e 383 3 friend friend NN cord-001273-plz1ja2e 383 4 or or CC cord-001273-plz1ja2e 383 5 foe foe NN cord-001273-plz1ja2e 383 6 ? ? . cord-001273-plz1ja2e 384 1 Genetic genetic JJ cord-001273-plz1ja2e 384 2 deficiencies deficiency NNS cord-001273-plz1ja2e 384 3 of of IN cord-001273-plz1ja2e 384 4 innate innate JJ cord-001273-plz1ja2e 384 5 immune immune JJ cord-001273-plz1ja2e 384 6 signalling signalling NN cord-001273-plz1ja2e 384 7 in in IN cord-001273-plz1ja2e 384 8 human human JJ cord-001273-plz1ja2e 384 9 infectious infectious JJ cord-001273-plz1ja2e 384 10 disease disease NN cord-001273-plz1ja2e 384 11 Characterization characterization NN cord-001273-plz1ja2e 384 12 of of IN cord-001273-plz1ja2e 384 13 the the DT cord-001273-plz1ja2e 384 14 murine murine JJ cord-001273-plz1ja2e 384 15 alpha alpha NN cord-001273-plz1ja2e 384 16 interferon interferon NN cord-001273-plz1ja2e 384 17 gene gene NN cord-001273-plz1ja2e 384 18 family family NN cord-001273-plz1ja2e 384 19 Listeria Listeria NNP cord-001273-plz1ja2e 384 20 pathogenesis pathogenesis NN cord-001273-plz1ja2e 384 21 and and CC cord-001273-plz1ja2e 385 1 molecular molecular JJ cord-001273-plz1ja2e 385 2 virulence virulence NN cord-001273-plz1ja2e 385 3 determinants determinant NNS cord-001273-plz1ja2e 385 4 Host host NN cord-001273-plz1ja2e 385 5 - - HYPH cord-001273-plz1ja2e 385 6 specific specific JJ cord-001273-plz1ja2e 385 7 response response NN cord-001273-plz1ja2e 385 8 to to IN cord-001273-plz1ja2e 385 9 HCV HCV NNP cord-001273-plz1ja2e 385 10 infection infection NN cord-001273-plz1ja2e 385 11 in in IN cord-001273-plz1ja2e 385 12 the the DT cord-001273-plz1ja2e 385 13 chimeric chimeric JJ cord-001273-plz1ja2e 385 14 SCIDbeige SCIDbeige NNS cord-001273-plz1ja2e 385 15 / / SYM cord-001273-plz1ja2e 385 16 Alb Alb NNP cord-001273-plz1ja2e 385 17 - - HYPH cord-001273-plz1ja2e 385 18 uPA uPA NNP cord-001273-plz1ja2e 385 19 mouse mouse NN cord-001273-plz1ja2e 385 20 model model NN cord-001273-plz1ja2e 385 21 : : : cord-001273-plz1ja2e 385 22 role role NN cord-001273-plz1ja2e 385 23 of of IN cord-001273-plz1ja2e 385 24 the the DT cord-001273-plz1ja2e 385 25 innate innate JJ cord-001273-plz1ja2e 385 26 antiviral antiviral JJ cord-001273-plz1ja2e 385 27 immune immune NN cord-001273-plz1ja2e 385 28 response response NN cord-001273-plz1ja2e 385 29 NOD1 NOD1 NNP cord-001273-plz1ja2e 385 30 contributes contribute VBZ cord-001273-plz1ja2e 385 31 to to IN cord-001273-plz1ja2e 385 32 mouse mouse NN cord-001273-plz1ja2e 385 33 host host NN cord-001273-plz1ja2e 385 34 defense defense NN cord-001273-plz1ja2e 385 35 against against IN cord-001273-plz1ja2e 385 36 Helicobacter Helicobacter NNP cord-001273-plz1ja2e 385 37 pylori pylori NN cord-001273-plz1ja2e 385 38 via via IN cord-001273-plz1ja2e 385 39 induction induction NN cord-001273-plz1ja2e 385 40 of of IN cord-001273-plz1ja2e 385 41 type type NN cord-001273-plz1ja2e 386 1 I -PRON- PRP cord-001273-plz1ja2e 386 2 IFN IFN NNP cord-001273-plz1ja2e 386 3 and and CC cord-001273-plz1ja2e 386 4 activation activation NN cord-001273-plz1ja2e 386 5 of of IN cord-001273-plz1ja2e 386 6 the the DT cord-001273-plz1ja2e 386 7 ISGF3 isgf3 NN cord-001273-plz1ja2e 386 8 signaling signal VBG cord-001273-plz1ja2e 386 9 pathway pathway NN cord-001273-plz1ja2e 386 10 Circulating circulate VBG cord-001273-plz1ja2e 386 11 virus virus NN cord-001273-plz1ja2e 386 12 , , , cord-001273-plz1ja2e 386 13 interferon interferon NN cord-001273-plz1ja2e 386 14 and and CC cord-001273-plz1ja2e 386 15 antibody antibody NN cord-001273-plz1ja2e 386 16 after after IN cord-001273-plz1ja2e 386 17 vaccination vaccination NN cord-001273-plz1ja2e 386 18 with with IN cord-001273-plz1ja2e 386 19 the the DT cord-001273-plz1ja2e 386 20 17-D 17-d CD cord-001273-plz1ja2e 386 21 strain strain NN cord-001273-plz1ja2e 386 22 of of IN cord-001273-plz1ja2e 386 23 yellow yellow JJ cord-001273-plz1ja2e 386 24 - - HYPH cord-001273-plz1ja2e 386 25 fever fever NN cord-001273-plz1ja2e 386 26 virus virus NN cord-001273-plz1ja2e 386 27 Decoding decode VBG cord-001273-plz1ja2e 386 28 the the DT cord-001273-plz1ja2e 386 29 complexity complexity NN cord-001273-plz1ja2e 386 30 of of IN cord-001273-plz1ja2e 386 31 type type NN cord-001273-plz1ja2e 387 1 I -PRON- PRP cord-001273-plz1ja2e 387 2 interferon interferon VBP cord-001273-plz1ja2e 387 3 to to TO cord-001273-plz1ja2e 387 4 treat treat VB cord-001273-plz1ja2e 387 5 persistent persistent JJ cord-001273-plz1ja2e 387 6 viral viral JJ cord-001273-plz1ja2e 387 7 infections infection NNS cord-001273-plz1ja2e 387 8 Epigenetic epigenetic JJ cord-001273-plz1ja2e 387 9 control control NN cord-001273-plz1ja2e 387 10 of of IN cord-001273-plz1ja2e 387 11 T T NNP cord-001273-plz1ja2e 387 12 - - HYPH cord-001273-plz1ja2e 387 13 helpercell helpercell NNP cord-001273-plz1ja2e 387 14 differentiation differentiation NN cord-001273-plz1ja2e 388 1 Innate innate JJ cord-001273-plz1ja2e 388 2 immune immune JJ cord-001273-plz1ja2e 388 3 pathways pathway NNS cord-001273-plz1ja2e 388 4 triggered trigger VBN cord-001273-plz1ja2e 388 5 by by IN cord-001273-plz1ja2e 388 6 Listeria Listeria NNP cord-001273-plz1ja2e 388 7 monocytogenes monocytogene NNS cord-001273-plz1ja2e 388 8 and and CC cord-001273-plz1ja2e 388 9 their -PRON- PRP$ cord-001273-plz1ja2e 388 10 role role NN cord-001273-plz1ja2e 388 11 in in IN cord-001273-plz1ja2e 388 12 the the DT cord-001273-plz1ja2e 388 13 induction induction NN cord-001273-plz1ja2e 388 14 of of IN cord-001273-plz1ja2e 388 15 cell cell NN cord-001273-plz1ja2e 388 16 - - HYPH cord-001273-plz1ja2e 388 17 mediated mediate VBN cord-001273-plz1ja2e 388 18 immunity immunity NN cord-001273-plz1ja2e 388 19 c c NN cord-001273-plz1ja2e 388 20 - - HYPH cord-001273-plz1ja2e 388 21 di di FW cord-001273-plz1ja2e 388 22 - - HYPH cord-001273-plz1ja2e 388 23 AMP amp NN cord-001273-plz1ja2e 388 24 secreted secrete VBN cord-001273-plz1ja2e 388 25 by by IN cord-001273-plz1ja2e 388 26 intracellular intracellular JJ cord-001273-plz1ja2e 388 27 Listeria Listeria NNP cord-001273-plz1ja2e 388 28 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 388 29 activates activate VBZ cord-001273-plz1ja2e 388 30 a a DT cord-001273-plz1ja2e 388 31 host host NN cord-001273-plz1ja2e 388 32 type type NN cord-001273-plz1ja2e 389 1 I -PRON- PRP cord-001273-plz1ja2e 389 2 interferon interferon VBD cord-001273-plz1ja2e 389 3 response response NN cord-001273-plz1ja2e 390 1 Cyclic cyclic JJ cord-001273-plz1ja2e 390 2 GMP GMP NNP cord-001273-plz1ja2e 390 3 - - HYPH cord-001273-plz1ja2e 390 4 AMP AMP NNP cord-001273-plz1ja2e 390 5 is be VBZ cord-001273-plz1ja2e 390 6 an an DT cord-001273-plz1ja2e 390 7 endogenous endogenous JJ cord-001273-plz1ja2e 390 8 second second JJ cord-001273-plz1ja2e 390 9 messenger messenger NN cord-001273-plz1ja2e 390 10 in in IN cord-001273-plz1ja2e 390 11 innate innate JJ cord-001273-plz1ja2e 390 12 immune immune JJ cord-001273-plz1ja2e 390 13 signaling signaling NN cord-001273-plz1ja2e 390 14 by by IN cord-001273-plz1ja2e 390 15 cytosolic cytosolic JJ cord-001273-plz1ja2e 390 16 DNA DNA NNP cord-001273-plz1ja2e 390 17 Listeria Listeria NNP cord-001273-plz1ja2e 390 18 monocytogenes monocytogenes NN cord-001273-plz1ja2e 390 19 strain strain NN cord-001273-plz1ja2e 390 20 - - HYPH cord-001273-plz1ja2e 390 21 specific specific JJ cord-001273-plz1ja2e 390 22 impairment impairment NN cord-001273-plz1ja2e 390 23 of of IN cord-001273-plz1ja2e 390 24 the the DT cord-001273-plz1ja2e 390 25 TetR TetR NNP cord-001273-plz1ja2e 390 26 regulator regulator NN cord-001273-plz1ja2e 390 27 underlies underlie VBZ cord-001273-plz1ja2e 390 28 the the DT cord-001273-plz1ja2e 390 29 drastic drastic JJ cord-001273-plz1ja2e 390 30 increase increase NN cord-001273-plz1ja2e 390 31 in in IN cord-001273-plz1ja2e 390 32 cyclic cyclic JJ cord-001273-plz1ja2e 390 33 di di FW cord-001273-plz1ja2e 390 34 - - HYPH cord-001273-plz1ja2e 390 35 AMP amp NN cord-001273-plz1ja2e 390 36 secretion secretion NN cord-001273-plz1ja2e 390 37 and and CC cord-001273-plz1ja2e 390 38 beta beta NN cord-001273-plz1ja2e 390 39 interferoninducing interferoninducing NN cord-001273-plz1ja2e 390 40 ability ability NN cord-001273-plz1ja2e 391 1 The the DT cord-001273-plz1ja2e 391 2 cytosolic cytosolic JJ cord-001273-plz1ja2e 391 3 nucleic nucleic JJ cord-001273-plz1ja2e 391 4 acid acid NN cord-001273-plz1ja2e 391 5 sensor sensor NN cord-001273-plz1ja2e 391 6 LRRFIP1 LRRFIP1 NNP cord-001273-plz1ja2e 391 7 mediates mediate VBZ cord-001273-plz1ja2e 391 8 the the DT cord-001273-plz1ja2e 391 9 production production NN cord-001273-plz1ja2e 391 10 of of IN cord-001273-plz1ja2e 391 11 type type NN cord-001273-plz1ja2e 392 1 I -PRON- PRP cord-001273-plz1ja2e 392 2 interferon interferon VBD cord-001273-plz1ja2e 392 3 via via IN cord-001273-plz1ja2e 392 4 a a DT cord-001273-plz1ja2e 392 5 β β NN cord-001273-plz1ja2e 392 6 - - HYPH cord-001273-plz1ja2e 392 7 catenin catenin NN cord-001273-plz1ja2e 392 8 - - HYPH cord-001273-plz1ja2e 392 9 dependent dependent JJ cord-001273-plz1ja2e 392 10 pathway pathway NN cord-001273-plz1ja2e 392 11 Innate innate JJ cord-001273-plz1ja2e 392 12 and and CC cord-001273-plz1ja2e 392 13 adaptive adaptive JJ cord-001273-plz1ja2e 392 14 immune immune JJ cord-001273-plz1ja2e 392 15 responses response NNS cord-001273-plz1ja2e 392 16 to to IN cord-001273-plz1ja2e 392 17 Listeria Listeria NNP cord-001273-plz1ja2e 392 18 monocytogenes monocytogenes NNP cord-001273-plz1ja2e 393 1 : : : cord-001273-plz1ja2e 393 2 a a DT cord-001273-plz1ja2e 393 3 short short JJ cord-001273-plz1ja2e 393 4 overview overview NN cord-001273-plz1ja2e 394 1 Interferon interferon NN cord-001273-plz1ja2e 394 2 - - HYPH cord-001273-plz1ja2e 394 3 λs λs JJ cord-001273-plz1ja2e 394 4 : : : cord-001273-plz1ja2e 394 5 special special JJ cord-001273-plz1ja2e 394 6 immunomodulatory immunomodulatory JJ cord-001273-plz1ja2e 394 7 agents agent NNS cord-001273-plz1ja2e 394 8 and and CC cord-001273-plz1ja2e 394 9 potential potential JJ cord-001273-plz1ja2e 394 10 therapeutic therapeutic JJ cord-001273-plz1ja2e 394 11 targets target NNS cord-001273-plz1ja2e 394 12 Stimulation stimulation NN cord-001273-plz1ja2e 394 13 of of IN cord-001273-plz1ja2e 394 14 inducible inducible JJ cord-001273-plz1ja2e 394 15 nitric nitric NN cord-001273-plz1ja2e 394 16 oxide oxide NN cord-001273-plz1ja2e 394 17 synthase synthase NN cord-001273-plz1ja2e 394 18 expression expression NN cord-001273-plz1ja2e 394 19 by by IN cord-001273-plz1ja2e 394 20 beta beta NN cord-001273-plz1ja2e 394 21 interferon interferon NN cord-001273-plz1ja2e 394 22 increases increase VBZ cord-001273-plz1ja2e 394 23 necrotic necrotic JJ cord-001273-plz1ja2e 394 24 death death NN cord-001273-plz1ja2e 394 25 of of IN cord-001273-plz1ja2e 394 26 macrophages macrophage NNS cord-001273-plz1ja2e 394 27 upon upon IN cord-001273-plz1ja2e 394 28 Listeria Listeria NNP cord-001273-plz1ja2e 394 29 monocytogenes monocytogene VBZ cord-001273-plz1ja2e 394 30 infection infection NN cord-001273-plz1ja2e 394 31 Conflict conflict NN cord-001273-plz1ja2e 394 32 of of IN cord-001273-plz1ja2e 394 33 Interest Interest NNP cord-001273-plz1ja2e 394 34 Statement Statement NNP cord-001273-plz1ja2e 394 35 : : : cord-001273-plz1ja2e 395 1 The the DT cord-001273-plz1ja2e 395 2 authors author NNS cord-001273-plz1ja2e 395 3 declare declare VBP cord-001273-plz1ja2e 395 4 that that IN cord-001273-plz1ja2e 395 5 the the DT cord-001273-plz1ja2e 395 6 research research NN cord-001273-plz1ja2e 395 7 was be VBD cord-001273-plz1ja2e 395 8 con con XX cord-001273-plz1ja2e 396 1 The the DT cord-001273-plz1ja2e 396 2 authors author NNS cord-001273-plz1ja2e 396 3 declare declare VBP cord-001273-plz1ja2e 396 4 no no DT cord-001273-plz1ja2e 396 5 conflict conflict NN cord-001273-plz1ja2e 396 6 of of IN cord-001273-plz1ja2e 396 7 interest interest NN cord-001273-plz1ja2e 396 8 . . . cord-001273-plz1ja2e 397 1 The the DT cord-001273-plz1ja2e 397 2 authors author NNS cord-001273-plz1ja2e 397 3 ' ' POS cord-001273-plz1ja2e 397 4 work work NN cord-001273-plz1ja2e 397 5 has have VBZ cord-001273-plz1ja2e 397 6 been be VBN cord-001273-plz1ja2e 397 7 supported support VBN cord-001273-plz1ja2e 397 8 in in IN cord-001273-plz1ja2e 397 9 part part NN cord-001273-plz1ja2e 397 10 by by IN cord-001273-plz1ja2e 397 11 the the DT cord-001273-plz1ja2e 397 12 Institut Institut NNP cord-001273-plz1ja2e 397 13 Pasteur Pasteur NNP cord-001273-plz1ja2e 397 14 , , , cord-001273-plz1ja2e 397 15 Inserm Inserm NNP cord-001273-plz1ja2e 397 16 , , , cord-001273-plz1ja2e 397 17 INRA INRA NNP cord-001273-plz1ja2e 397 18 , , , cord-001273-plz1ja2e 397 19 Université Université NNP cord-001273-plz1ja2e 397 20 Paris Paris NNP cord-001273-plz1ja2e 397 21 - - HYPH cord-001273-plz1ja2e 397 22 Diderot Diderot NNP cord-001273-plz1ja2e 397 23 , , , cord-001273-plz1ja2e 397 24 LabEx LabEx NNP cord-001273-plz1ja2e 397 25 IBEID IBEID NNP cord-001273-plz1ja2e 397 26 , , , cord-001273-plz1ja2e 397 27 ANR ANR NNP cord-001273-plz1ja2e 397 28 ( ( -LRB- cord-001273-plz1ja2e 397 29 Grant Grant NNP cord-001273-plz1ja2e 397 30 EPILIS EPILIS NNP cord-001273-plz1ja2e 397 31 ) ) -RRB- cord-001273-plz1ja2e 397 32 , , , cord-001273-plz1ja2e 397 33 French French NNP cord-001273-plz1ja2e 397 34 Ligue Ligue NNP cord-001273-plz1ja2e 397 35 Nationale Nationale NNP cord-001273-plz1ja2e 397 36 contre contre FW cord-001273-plz1ja2e 397 37 le le NNP cord-001273-plz1ja2e 397 38 Cancer Cancer NNP cord-001273-plz1ja2e 397 39 , , , cord-001273-plz1ja2e 397 40 Fondation Fondation NNP cord-001273-plz1ja2e 397 41 Louis Louis NNP cord-001273-plz1ja2e 397 42 - - HYPH cord-001273-plz1ja2e 397 43 Jeantet Jeantet NNP cord-001273-plz1ja2e 397 44 , , , cord-001273-plz1ja2e 397 45 Fondation Fondation NNP cord-001273-plz1ja2e 397 46 Le Le NNP cord-001273-plz1ja2e 397 47 Roch Roch NNP cord-001273-plz1ja2e 397 48 , , , cord-001273-plz1ja2e 397 49 and and CC cord-001273-plz1ja2e 397 50 European European NNP cord-001273-plz1ja2e 397 51 Research Research NNP cord-001273-plz1ja2e 397 52 Council Council NNP cord-001273-plz1ja2e 397 53 ( ( -LRB- cord-001273-plz1ja2e 397 54 Advanced Advanced NNP cord-001273-plz1ja2e 397 55 Grant Grant NNP cord-001273-plz1ja2e 397 56 Award Award NNP cord-001273-plz1ja2e 397 57 233348 233348 CD cord-001273-plz1ja2e 397 58 to to IN cord-001273-plz1ja2e 397 59 Pascale Pascale NNP cord-001273-plz1ja2e 397 60 Cossart Cossart NNP cord-001273-plz1ja2e 397 61 ) ) -RRB- cord-001273-plz1ja2e 397 62 . . . cord-001273-plz1ja2e 398 1 Pascale Pascale NNP cord-001273-plz1ja2e 398 2 Cossart Cossart NNP cord-001273-plz1ja2e 398 3 is be VBZ cord-001273-plz1ja2e 398 4 an an DT cord-001273-plz1ja2e 398 5 international international JJ cord-001273-plz1ja2e 398 6 research research NN cord-001273-plz1ja2e 398 7 scholar scholar NN cord-001273-plz1ja2e 398 8 of of IN cord-001273-plz1ja2e 398 9 the the DT cord-001273-plz1ja2e 398 10 Howard Howard NNP cord-001273-plz1ja2e 398 11 Hughes Hughes NNP cord-001273-plz1ja2e 398 12 Medical Medical NNP cord-001273-plz1ja2e 398 13 Institute Institute NNP cord-001273-plz1ja2e 398 14 . . .