id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-299756-m0va36er	Raaben, Matthijs	Type I interferon receptor-independent and -dependent host transcriptional responses to mouse hepatitis coronavirus infection in vivo	2009-08-03		.txt	text/plain	4568	258	54	As the BALB/c and the IFNAR-/129SvEv mice demonstrated very similar viral loads in their brains, we also compared their gene expression profiles upon infection with MHV in order to identify type I IFN-dependent transcriptional responses. CONCLUSION: Transcriptional profiling of mice infected with MHV demonstrated the induction of a robust IFN response, which correlated with the viral load. Furthermore, gene expression profiling of 129SvEv mice lacking the type I IFN receptor, which are not able to control the MHV infection [11] , allowed us to identify type I IFN-independent transcriptional responses. To study the role of type I IFN-independent and -dependent gene expression in the control of MHV infection in vivo in more detail, we next made use of the IFNAR-/-mice [30] . Transcriptional profiling of mice infected with MHV demonstrated the induction of a robust IFN response, which correlated with the viral load.	./cache/cord-299756-m0va36er.txt	./txt/cord-299756-m0va36er.txt