id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-260793-bb4h255w	Brann, David H.	Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia	2020-05-18		.txt	text/plain	11985	604	53	It has recently been demonstrated through single cell RNA sequencing analysis (referred to herein as scSeq) that cells from the human upper airway -including nasal RE goblet, basal and ciliated cells -express high levels of ACE2 and TMPRSS2, suggesting that these RE cell types may serve as a viral reservoir during CoV-2 infection (33) . The presence of Ace2 and Tmprss2 transcripts in mouse WOM and their (near total) absence in purified OSNs suggest that the molecular components that enable CoV-2 entry into cells are expressed in non-neuronal cell types in the mouse nasal epithelium. An independent mouse scSeq data set (obtained using the 10x Chromium platform, see Methods) revealed that olfactory sensory neurons did not express Ace2 (2 of 28769 mature OSNs were positive for Ace2), while expression was observed in a fraction of Bowman's gland cells and HBCs ( Figure S4 , see methods).	./cache/cord-260793-bb4h255w.txt	./txt/cord-260793-bb4h255w.txt