id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-010657-5qtsj8xv	Heckman, Carol A.	Pathogenesis of Lesions Induced in Rat Lung by Chronic Tobacco Smoke Inhalation	1982-07-01		.txt	text/plain	4324	280	48	In serially killed animals, four types of lesions were found: 1) perivascular or peribronchiolar accumulation of lymphoreticular cells, 2) fibrotic and cellular enlargement of peribronchiolar septa, 3) type II cell hyperplasia with septal fibrosis, and 4) air-space enlargement (emphysema). The type II hyperplastic and peribronchiolar alveolar lesions involved larger portions of the parenchyma in fibrotic changes but differed in structure, location, and frequency. In studies by Roe's group (1, 2) , the major lesions induced in the rat lung by lifetime exposure were columnar, cuboidal, and squamous metaplasias of the alveolar epithelium. (3) on rats exposed to tobacco smoke for 6 weeks showed characteristic lesions at the level of the respiratory bronchiole, including peribronchiolar and perivascular infiltration by lymphocytes, focal pneumonitis, and alveolar cuboidal or columnar metaplasia. The present studies have shown that the most common type of focal lesions to develop in the lungs of tobacco smoke-exposed animals consisted of accumulated lymphocytes and macrophages in the vascular adventitia.	./cache/cord-010657-5qtsj8xv.txt	./txt/cord-010657-5qtsj8xv.txt