id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001124-qcjbtflt	Carrero, Javier Antonio	Confounding roles for type I interferons during bacterial and viral pathogenesis	2013-10-24		.txt	text/plain	4545	276	42	Although type I interferons (IFN-I) were initially defined as potent antiviral agents, they can also cause decreased host resistance to some bacterial and viral infections. In contrast, there is a negative effect of IFN-I on host resistance during chronic infection with lymphocytic choriomeningitis virus (LCMV) and acute infections with intracellular bacteria. Following Listeria infection, IFN-I promote the cell death of macrophages and lymphocytes, which leads to innate immune suppression. Because of the extent of the IFN-I literature, this review will mostly limit itself to experiments that have examined viral and bacterial pathogenesis in IFNAR -/mice with a particular emphasis on work that has examined lethality and pathogen burden. In the case of influenza and potentially other respiratory viruses, the type III interferon system (which comprises IFN-λ subtypes and signals using IL-10R2-IFNLR1) plays a dominant role in restricting acute epithelial cell infection, thereby limiting the requirement of IFN-I signaling (10, 11) . Production of type I IFN sensitizes macrophages to cell death induced by Listeria monocytogenes	./cache/cord-001124-qcjbtflt.txt	./txt/cord-001124-qcjbtflt.txt