id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-316626-258rbcwb	Serpa Neto, Ary	Will Evidence-based Medicine Survive the COVID-19 Pandemic?	2020-09-17		.txt	text/plain	1459	71	43	One major challenge during the pandemic is to design clinical trials that can mitigate these concerns and quickly identify effective or harmful interventions to improve patient outcomes. In a pandemic with more than 75,000 new cases per day, the use of a Bayesian adaptive trial design can quickly incorporate existing evidence, drop interventions that have a higher probability of futility, redirect patients to be randomized to the most promising ones, and constantly include new and potential candidate interventions. 1144-1153) (13) describe the study protocol of a randomized, doubleblind, placebo-controlled clinical trial (ORCHID trial) assessing the impact of hydroxychloroquine in hospitalized adults with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) and symptoms of acute respiratory infection. Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a randomized clinical trial Rationale and design of ORCHID: a randomized placebo-controlled clinical trial of hydroxychloroquine for adults hospitalized with COVID-19	./cache/cord-316626-258rbcwb.txt	./txt/cord-316626-258rbcwb.txt