id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-280020-nrnc8u28	Zhao, Yang	Appealing for Efficient, Well Organized Clinical Trials on COVID-19	2020-03-07		.txt	text/plain	907	65	50	We reviewed the characteristics of interventional trials from Chinese Clinical Trial Registration (ChiCTR) and ClinicalTrials.gov. We found some studies with potential defects including unreasonable design, inappropriate primary endpoint definition, insufficient sample size and ethical issue. Herein, we reviewed the characteristics of interventional trials from Chinese Clinical Trial Registration (ChiCTR) and Two authors (Zhao and Shen) were independently responsible for collecting the relevant information, including clinical phase, study design, presence or absence of randomization, blinding, sample size, severity of disease and source of samples. Through analyzing currently-registered interventional trials, we found some studies with potential defects including unreasonable design, inappropriate PE definition, small sample size and ethical issue. https://doi.org/10.1101/2020.03.05.20031476 doi: medRxiv preprint As appealed by some Chinese scientists recently, clinical trials on COVID-19 should be designed based on scientific rules (appropriate controls, randomization, blinding, and sufficient sample size)，ethics and patients' benefits 5 CC-BY-NC 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.	./cache/cord-280020-nrnc8u28.txt	./txt/cord-280020-nrnc8u28.txt