id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-336687-iw3bzy0m	Kraemer, M. U. G.	Big city, small world: density, contact rates, and transmission of dengue across Pakistan	2015-10-06		.txt	text/plain	4517	231	41	Here, we fitted a mathematical model of dengue virus transmission to spatial time-series data from Pakistan and compared maximum-likelihood estimates of 'mixing parameters' when disaggregating data across an urban–rural gradient. Accounting for differences in mobility by incorporating two fine-scale, density-dependent covariate layers eliminates differences in mixing but results in a doubling of the estimated transmission potential of the large urban district of Lahore. In no application of the TSIR model to date has the potential for variation in these parameters been assessed, leaving the extent to which inhomogeneity of mixing varies across space and time as an open question in the study of infectious disease dynamics. To assess the potential for spatial variation in the inhomogeneity of mixing as it pertains dengue transmission, we performed an analysis of district-level time series of dengue transmission in the Punjab province of Pakistan using a TSIR model with separate mixing parameters for urban and rural districts.	./cache/cord-336687-iw3bzy0m.txt	./txt/cord-336687-iw3bzy0m.txt