id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-341690-h8fqijk5	Hu, Weiwei	The epidermal growth factor receptor regulates cofilin activity and promotes transmissible gastroenteritis virus entry into intestinal epithelial cells	2016-02-25		.txt	text/plain	7529	432	55	title: The epidermal growth factor receptor regulates cofilin activity and promotes transmissible gastroenteritis virus entry into intestinal epithelial cells The TGEV spike protein is capable of binding with EGFR, activating the downstream phosphoinositide-3 kinase (PI3K), then causing the phosphorylation of cofilin and F-actin polymerization via Rac1/Cdc42 GTPases. We found that TGEV acted via the EGFR-PI3K-Rac1/Cdc42-PAK-LIMK signaling pathway to regulate the activity of cofilin and F-actin arrangement early in infection, and also demonstrated that EGFR was a promoter for TGEV entry. During the early phase of TGEV infection, the destruction of lipid rafts inhibited the activation of EGFR, Akt, and LIMK, and also inhibited the phosphorylation of cofilin ( Figure 7E ). Our results also indicate that TGEV binding induces the phosphorylation of cofilin through the EGFR-PI3K-Rac1/ Cdc42-PAK-LIMK signaling pathways, resulting in actin polymerization around the cell membrane and foming multiple poutrusions.	./cache/cord-341690-h8fqijk5.txt	./txt/cord-341690-h8fqijk5.txt