id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-265224-mwgccr4a	Delmas, Bernard	Aminopeptidase N is a major receptor for the enteropathogenic coronavirus TGEV	1992		.txt	text/plain	2107	117	51	Further evidence that the anti-TGEV-receptor antibodies recognized aminopeptidase N was obtained by showing that (1) an antibody raised against rabbit aminopeptidase N 4 reacted with the same three polypeptides in brush-border membrane preparations (Fig. 2, lane 2) : 95K and 50K, corresponding to the B (amino) and C (carboxy) subunits of the pig aminopeptidase, and 150K, uncleaved aminopeptidase 5 ; (2) the immunoprecipitated material hydrolysed leucine p-nitroanilide, a chromogenic substrate specific for aminopeptidase (ref. A monoclonal antibody designated RBS protected WI38 and RD human cell lines from HCV-229E-induced cytopathic effects and protected WI38 cells from virus infection ( Fig. la-c) . Because aminopeptidase from humans, pigs and other mammals are structurally similar 9 , 12-14, we investigated whether HCV-229E and RBS would bind specifically to hAPN and whether expression of hAPN by murine cells would make them susceptible to infection with HCV-229E.	./cache/cord-265224-mwgccr4a.txt	./txt/cord-265224-mwgccr4a.txt