id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-021511-88xaynf7	Werner, Linda L.	Immunologic and Plasma Protein Disorders	2009-05-15		.txt	text/plain	6195	376	34	Hypoalbuminemia associated with hepatomegaly; microhepatia; neurologic signs; icterus; decreased blood urea nitrogen (BUN) with or without increased alanine aminotransferase (ALT), serum alkaline phosphatase (SAP), or both; or abnormal hepatic function test results (e.g., serum bile acids) requires a diagnostic workup for hepatic insufficiency (see Chapter 9). Occasionally Indicated • Protein electrophoresis is performed when hyperglobulinemia is not caused by hemoconcentration and either (1) the globulin concentration is high enough to make monoclonal gammopathy a reasonable possibility or (2) humoral immunodeficiencies are suspected. Immunoelectrophoresis is the method of choice to detect urinary and serum Bence Jones protein, a monoclonal protein equivalent to immunoglobulin light chains which occasionally occurs in multiple myeloma and macroglobulinemia. Monoclonal immunoglobulin elevations are also called paraproteins or M proteins and are usually the result of lymphocyte and plasma cell neoplasias (e.g., multiple myeloma, macroglobulinemia, lymphosarcoma; see Table 12 -3). Diagnosis of multiple myeloma in dogs requires finding at least two of the following: lytic skeletal lesions, bone marrow plasmacytosis, Bence Jones proteinuria, or a monoclonal spike on serum protein electrophoresis.	./cache/cord-021511-88xaynf7.txt	./txt/cord-021511-88xaynf7.txt