id	sid	tid	token	lemma	pos
cord-015684-q10sx1dm	1	1	key	key	JJ
cord-015684-q10sx1dm	1	2	:	:	:
cord-015684-q10sx1dm	1	3	cord-015684-q10sx1	cord-015684-q10sx1	JJ
cord-015684-q10sx1dm	1	4	dm	dm	NN
cord-015684-q10sx1dm	1	5	authors	author	NNS
cord-015684-q10sx1dm	1	6	:	:	:
cord-015684-q10sx1dm	1	7	Cacabelos	cacabelos	RB
cord-015684-q10sx1dm	1	8	,	,	,
cord-015684-q10sx1dm	1	9	Ramón	Ramón	NNP
cord-015684-q10sx1dm	1	10	title	title	NN
cord-015684-q10sx1dm	1	11	:	:	:
cord-015684-q10sx1dm	1	12	Pharmacogenomic	Pharmacogenomic	NNP
cord-015684-q10sx1dm	1	13	Biomarkers	Biomarkers	NNPS
cord-015684-q10sx1dm	1	14	in	in	IN
cord-015684-q10sx1dm	1	15	Neuropsychiatry	Neuropsychiatry	NNP
cord-015684-q10sx1dm	1	16	:	:	:
cord-015684-q10sx1dm	2	1	The	the	DT
cord-015684-q10sx1dm	2	2	Path	Path	NNP
cord-015684-q10sx1dm	2	3	to	to	IN
cord-015684-q10sx1dm	2	4	Personalized	Personalized	NNP
cord-015684-q10sx1dm	2	5	Medicine	Medicine	NNP
cord-015684-q10sx1dm	2	6	in	in	IN
cord-015684-q10sx1dm	2	7	Mental	Mental	NNP
cord-015684-q10sx1dm	2	8	Disorders	Disorders	NNPS
cord-015684-q10sx1dm	2	9	date	date	NN
cord-015684-q10sx1dm	2	10	:	:	:
cord-015684-q10sx1dm	3	1	2009	2009	CD
cord-015684-q10sx1dm	3	2	journal	journal	NNP
cord-015684-q10sx1dm	3	3	:	:	:
cord-015684-q10sx1dm	4	1	The	the	DT
cord-015684-q10sx1dm	4	2	Handbook	Handbook	NNP
cord-015684-q10sx1dm	4	3	of	of	IN
cord-015684-q10sx1dm	4	4	Neuropsychiatric	Neuropsychiatric	NNP
cord-015684-q10sx1dm	4	5	Biomarkers	Biomarkers	NNPS
cord-015684-q10sx1dm	4	6	,	,	,
cord-015684-q10sx1dm	4	7	Endophenotypes	Endophenotypes	NNP
cord-015684-q10sx1dm	4	8	and	and	CC
cord-015684-q10sx1dm	4	9	Genes	Genes	NNPS
cord-015684-q10sx1dm	4	10	DOI	DOI	NNP
cord-015684-q10sx1dm	4	11	:	:	:
cord-015684-q10sx1dm	5	1	10.1007/978	10.1007/978	LS
cord-015684-q10sx1dm	5	2	-	-	SYM
cord-015684-q10sx1dm	5	3	90	90	CD
cord-015684-q10sx1dm	5	4	-	-	HYPH
cord-015684-q10sx1dm	5	5	481	481	CD
cord-015684-q10sx1dm	5	6	-	-	HYPH
cord-015684-q10sx1dm	5	7	2298	2298	CD
cord-015684-q10sx1dm	5	8	-	-	SYM
cord-015684-q10sx1dm	5	9	1_1	1_1	CD
cord-015684-q10sx1dm	5	10	sha	sha	NN
cord-015684-q10sx1dm	5	11	:	:	:
cord-015684-q10sx1dm	5	12	0a63872b4b6c7baa3afe4277f6b225856e281054	0a63872b4b6c7baa3afe4277f6b225856e281054	XX
cord-015684-q10sx1dm	6	1	doc_id	doc_id	CD
cord-015684-q10sx1dm	6	2	:	:	:
cord-015684-q10sx1dm	6	3	15684	15684	CD
cord-015684-q10sx1dm	6	4	cord_uid	cord_uid	NNS
cord-015684-q10sx1dm	6	5	:	:	:
cord-015684-q10sx1dm	7	1	q10sx1	q10sx1	:
cord-015684-q10sx1dm	7	2	dm	dm	NNP
cord-015684-q10sx1dm	7	3	Neuropsychiatric	neuropsychiatric	JJ
cord-015684-q10sx1dm	7	4	disorders	disorder	NNS
cord-015684-q10sx1dm	7	5	and	and	CC
cord-015684-q10sx1dm	7	6	dementia	dementia	NN
cord-015684-q10sx1dm	7	7	represent	represent	VBP
cord-015684-q10sx1dm	7	8	a	a	DT
cord-015684-q10sx1dm	7	9	major	major	JJ
cord-015684-q10sx1dm	7	10	cause	cause	NN
cord-015684-q10sx1dm	7	11	of	of	IN
cord-015684-q10sx1dm	7	12	disability	disability	NN
cord-015684-q10sx1dm	7	13	and	and	CC
cord-015684-q10sx1dm	7	14	high	high	JJ
cord-015684-q10sx1dm	7	15	cost	cost	NN
cord-015684-q10sx1dm	7	16	in	in	IN
cord-015684-q10sx1dm	7	17	developed	develop	VBN
cord-015684-q10sx1dm	7	18	societies	society	NNS
cord-015684-q10sx1dm	7	19	.	.	.
cord-015684-q10sx1dm	8	1	Most	Most	JJS
cord-015684-q10sx1dm	8	2	disorders	disorder	NNS
cord-015684-q10sx1dm	8	3	of	of	IN
cord-015684-q10sx1dm	8	4	the	the	DT
cord-015684-q10sx1dm	8	5	central	central	JJ
cord-015684-q10sx1dm	8	6	nervous	nervous	JJ
cord-015684-q10sx1dm	8	7	system	system	NN
cord-015684-q10sx1dm	8	8	(	(	-LRB-
cord-015684-q10sx1dm	8	9	CNS	CNS	NNP
cord-015684-q10sx1dm	8	10	)	)	-RRB-
cord-015684-q10sx1dm	8	11	share	share	VBP
cord-015684-q10sx1dm	8	12	some	some	DT
cord-015684-q10sx1dm	8	13	common	common	JJ
cord-015684-q10sx1dm	8	14	features	feature	NNS
cord-015684-q10sx1dm	8	15	,	,	,
cord-015684-q10sx1dm	8	16	such	such	JJ
cord-015684-q10sx1dm	8	17	as	as	IN
cord-015684-q10sx1dm	8	18	a	a	DT
cord-015684-q10sx1dm	8	19	genomic	genomic	JJ
cord-015684-q10sx1dm	8	20	background	background	NN
cord-015684-q10sx1dm	8	21	in	in	IN
cord-015684-q10sx1dm	8	22	which	which	WDT
cord-015684-q10sx1dm	8	23	hundreds	hundred	NNS
cord-015684-q10sx1dm	8	24	of	of	IN
cord-015684-q10sx1dm	8	25	genes	gene	NNS
cord-015684-q10sx1dm	8	26	might	may	MD
cord-015684-q10sx1dm	8	27	be	be	VB
cord-015684-q10sx1dm	8	28	involved	involve	VBN
cord-015684-q10sx1dm	8	29	,	,	,
cord-015684-q10sx1dm	8	30	genome	genome	NN
cord-015684-q10sx1dm	8	31	-	-	HYPH
cord-015684-q10sx1dm	8	32	environment	environment	NN
cord-015684-q10sx1dm	8	33	interactions	interaction	NNS
cord-015684-q10sx1dm	8	34	,	,	,
cord-015684-q10sx1dm	8	35	complex	complex	JJ
cord-015684-q10sx1dm	8	36	pathogenic	pathogenic	JJ
cord-015684-q10sx1dm	8	37	pathways	pathway	NNS
cord-015684-q10sx1dm	8	38	,	,	,
cord-015684-q10sx1dm	8	39	poor	poor	JJ
cord-015684-q10sx1dm	8	40	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	8	41	outcomes	outcome	NNS
cord-015684-q10sx1dm	8	42	,	,	,
cord-015684-q10sx1dm	8	43	and	and	CC
cord-015684-q10sx1dm	8	44	chronic	chronic	JJ
cord-015684-q10sx1dm	8	45	disability	disability	NN
cord-015684-q10sx1dm	8	46	.	.	.
cord-015684-q10sx1dm	9	1	Recent	recent	JJ
cord-015684-q10sx1dm	9	2	advances	advance	NNS
cord-015684-q10sx1dm	9	3	in	in	IN
cord-015684-q10sx1dm	9	4	genomic	genomic	JJ
cord-015684-q10sx1dm	9	5	medicine	medicine	NN
cord-015684-q10sx1dm	9	6	can	can	MD
cord-015684-q10sx1dm	9	7	contribute	contribute	VB
cord-015684-q10sx1dm	9	8	to	to	TO
cord-015684-q10sx1dm	9	9	accelerate	accelerate	VB
cord-015684-q10sx1dm	9	10	our	-PRON-	PRP$
cord-015684-q10sx1dm	9	11	understanding	understanding	NN
cord-015684-q10sx1dm	9	12	on	on	IN
cord-015684-q10sx1dm	9	13	the	the	DT
cord-015684-q10sx1dm	9	14	pathogenesis	pathogenesis	NN
cord-015684-q10sx1dm	9	15	of	of	IN
cord-015684-q10sx1dm	9	16	CNS	CNS	NNP
cord-015684-q10sx1dm	9	17	disorders	disorder	NNS
cord-015684-q10sx1dm	9	18	,	,	,
cord-015684-q10sx1dm	9	19	improve	improve	VB
cord-015684-q10sx1dm	9	20	diagnostic	diagnostic	JJ
cord-015684-q10sx1dm	9	21	accuracy	accuracy	NN
cord-015684-q10sx1dm	9	22	with	with	IN
cord-015684-q10sx1dm	9	23	the	the	DT
cord-015684-q10sx1dm	9	24	introduction	introduction	NN
cord-015684-q10sx1dm	9	25	of	of	IN
cord-015684-q10sx1dm	9	26	novel	novel	JJ
cord-015684-q10sx1dm	9	27	biomarkers	biomarker	NNS
cord-015684-q10sx1dm	9	28	,	,	,
cord-015684-q10sx1dm	9	29	and	and	CC
cord-015684-q10sx1dm	9	30	personalize	personalize	VB
cord-015684-q10sx1dm	9	31	therapeutics	therapeutic	NNS
cord-015684-q10sx1dm	9	32	with	with	IN
cord-015684-q10sx1dm	9	33	the	the	DT
cord-015684-q10sx1dm	9	34	incorporation	incorporation	NN
cord-015684-q10sx1dm	9	35	of	of	IN
cord-015684-q10sx1dm	9	36	pharmacogenetic	pharmacogenetic	NNP
cord-015684-q10sx1dm	9	37	and	and	CC
cord-015684-q10sx1dm	9	38	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	9	39	procedures	procedure	NNS
cord-015684-q10sx1dm	9	40	to	to	IN
cord-015684-q10sx1dm	9	41	drug	drug	NN
cord-015684-q10sx1dm	9	42	development	development	NN
cord-015684-q10sx1dm	9	43	and	and	CC
cord-015684-q10sx1dm	9	44	clinical	clinical	JJ
cord-015684-q10sx1dm	9	45	practice	practice	NN
cord-015684-q10sx1dm	9	46	.	.	.
cord-015684-q10sx1dm	10	1	The	the	DT
cord-015684-q10sx1dm	10	2	pharmacological	pharmacological	JJ
cord-015684-q10sx1dm	10	3	treatment	treatment	NN
cord-015684-q10sx1dm	10	4	of	of	IN
cord-015684-q10sx1dm	10	5	CNS	CNS	NNP
cord-015684-q10sx1dm	10	6	disorders	disorder	NNS
cord-015684-q10sx1dm	10	7	,	,	,
cord-015684-q10sx1dm	10	8	in	in	IN
cord-015684-q10sx1dm	10	9	general	general	JJ
cord-015684-q10sx1dm	10	10	,	,	,
cord-015684-q10sx1dm	10	11	accounts	account	VBZ
cord-015684-q10sx1dm	10	12	for	for	IN
cord-015684-q10sx1dm	10	13	10–20	10–20	CD
cord-015684-q10sx1dm	10	14	%	%	NN
cord-015684-q10sx1dm	10	15	of	of	IN
cord-015684-q10sx1dm	10	16	direct	direct	JJ
cord-015684-q10sx1dm	10	17	costs	cost	NNS
cord-015684-q10sx1dm	10	18	,	,	,
cord-015684-q10sx1dm	10	19	and	and	CC
cord-015684-q10sx1dm	10	20	less	less	JJR
cord-015684-q10sx1dm	10	21	than	than	IN
cord-015684-q10sx1dm	10	22	30–40	30–40	CD
cord-015684-q10sx1dm	10	23	%	%	NN
cord-015684-q10sx1dm	10	24	of	of	IN
cord-015684-q10sx1dm	10	25	the	the	DT
cord-015684-q10sx1dm	10	26	patients	patient	NNS
cord-015684-q10sx1dm	10	27	are	be	VBP
cord-015684-q10sx1dm	10	28	moderate	moderate	JJ
cord-015684-q10sx1dm	10	29	responders	responder	NNS
cord-015684-q10sx1dm	10	30	to	to	IN
cord-015684-q10sx1dm	10	31	conventional	conventional	JJ
cord-015684-q10sx1dm	10	32	drugs	drug	NNS
cord-015684-q10sx1dm	10	33	,	,	,
cord-015684-q10sx1dm	10	34	some	some	DT
cord-015684-q10sx1dm	10	35	of	of	IN
cord-015684-q10sx1dm	10	36	which	which	WDT
cord-015684-q10sx1dm	10	37	may	may	MD
cord-015684-q10sx1dm	10	38	cause	cause	VB
cord-015684-q10sx1dm	10	39	important	important	JJ
cord-015684-q10sx1dm	10	40	adverse	adverse	JJ
cord-015684-q10sx1dm	10	41	drugs	drug	NNS
cord-015684-q10sx1dm	10	42	reactions	reaction	NNS
cord-015684-q10sx1dm	10	43	(	(	-LRB-
cord-015684-q10sx1dm	10	44	ADRs	adr	NNS
cord-015684-q10sx1dm	10	45	)	)	-RRB-
cord-015684-q10sx1dm	10	46	.	.	.
cord-015684-q10sx1dm	11	1	Pharmacogenetic	pharmacogenetic	JJ
cord-015684-q10sx1dm	11	2	and	and	CC
cord-015684-q10sx1dm	11	3	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	11	4	factors	factor	NNS
cord-015684-q10sx1dm	11	5	may	may	MD
cord-015684-q10sx1dm	11	6	account	account	VB
cord-015684-q10sx1dm	11	7	for	for	IN
cord-015684-q10sx1dm	11	8	60–90	60–90	CD
cord-015684-q10sx1dm	11	9	%	%	NN
cord-015684-q10sx1dm	11	10	of	of	IN
cord-015684-q10sx1dm	11	11	drug	drug	NN
cord-015684-q10sx1dm	11	12	variability	variability	NN
cord-015684-q10sx1dm	11	13	in	in	IN
cord-015684-q10sx1dm	11	14	drug	drug	NN
cord-015684-q10sx1dm	11	15	disposition	disposition	NN
cord-015684-q10sx1dm	11	16	and	and	CC
cord-015684-q10sx1dm	11	17	pharmacodynamics	pharmacodynamic	NNS
cord-015684-q10sx1dm	11	18	.	.	.
cord-015684-q10sx1dm	12	1	Approximately	approximately	RB
cord-015684-q10sx1dm	12	2	60–80	60–80	CD
cord-015684-q10sx1dm	12	3	%	%	NN
cord-015684-q10sx1dm	12	4	of	of	IN
cord-015684-q10sx1dm	12	5	CNS	CNS	NNP
cord-015684-q10sx1dm	12	6	drugs	drug	NNS
cord-015684-q10sx1dm	12	7	are	be	VBP
cord-015684-q10sx1dm	12	8	metabolized	metabolize	VBN
cord-015684-q10sx1dm	12	9	via	via	IN
cord-015684-q10sx1dm	12	10	enzymes	enzyme	NNS
cord-015684-q10sx1dm	12	11	of	of	IN
cord-015684-q10sx1dm	12	12	the	the	DT
cord-015684-q10sx1dm	12	13	CYP	CYP	NNP
cord-015684-q10sx1dm	12	14	gene	gene	NN
cord-015684-q10sx1dm	12	15	superfamily	superfamily	NN
cord-015684-q10sx1dm	12	16	;	;	:
cord-015684-q10sx1dm	12	17	18	18	CD
cord-015684-q10sx1dm	12	18	%	%	NN
cord-015684-q10sx1dm	12	19	of	of	IN
cord-015684-q10sx1dm	12	20	neuroleptics	neuroleptic	NNS
cord-015684-q10sx1dm	12	21	are	be	VBP
cord-015684-q10sx1dm	12	22	major	major	JJ
cord-015684-q10sx1dm	12	23	substrates	substrate	NNS
cord-015684-q10sx1dm	12	24	of	of	IN
cord-015684-q10sx1dm	12	25	CYP1A2	CYP1A2	NNP
cord-015684-q10sx1dm	12	26	enzymes	enzyme	NNS
cord-015684-q10sx1dm	12	27	,	,	,
cord-015684-q10sx1dm	12	28	40	40	CD
cord-015684-q10sx1dm	12	29	%	%	NN
cord-015684-q10sx1dm	12	30	of	of	IN
cord-015684-q10sx1dm	12	31	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	12	32	,	,	,
cord-015684-q10sx1dm	12	33	and	and	CC
cord-015684-q10sx1dm	12	34	23	23	CD
cord-015684-q10sx1dm	12	35	%	%	NN
cord-015684-q10sx1dm	12	36	of	of	IN
cord-015684-q10sx1dm	12	37	CYP3A4	CYP3A4	NNP
cord-015684-q10sx1dm	12	38	;	;	:
cord-015684-q10sx1dm	12	39	24	24	CD
cord-015684-q10sx1dm	12	40	%	%	NN
cord-015684-q10sx1dm	12	41	of	of	IN
cord-015684-q10sx1dm	12	42	antidepressants	antidepressant	NNS
cord-015684-q10sx1dm	12	43	are	be	VBP
cord-015684-q10sx1dm	12	44	major	major	JJ
cord-015684-q10sx1dm	12	45	substrates	substrate	NNS
cord-015684-q10sx1dm	12	46	of	of	IN
cord-015684-q10sx1dm	12	47	CYP1A2	CYP1A2	NNP
cord-015684-q10sx1dm	12	48	enzymes	enzyme	NNS
cord-015684-q10sx1dm	12	49	,	,	,
cord-015684-q10sx1dm	12	50	5	5	CD
cord-015684-q10sx1dm	12	51	%	%	NN
cord-015684-q10sx1dm	12	52	of	of	IN
cord-015684-q10sx1dm	12	53	CYP2B6	CYP2B6	NNP
cord-015684-q10sx1dm	12	54	,	,	,
cord-015684-q10sx1dm	12	55	38	38	CD
cord-015684-q10sx1dm	12	56	%	%	NN
cord-015684-q10sx1dm	12	57	of	of	IN
cord-015684-q10sx1dm	12	58	CYP2C19	CYP2C19	NNP
cord-015684-q10sx1dm	12	59	,	,	,
cord-015684-q10sx1dm	12	60	85	85	CD
cord-015684-q10sx1dm	12	61	%	%	NN
cord-015684-q10sx1dm	12	62	of	of	IN
cord-015684-q10sx1dm	12	63	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	12	64	,	,	,
cord-015684-q10sx1dm	12	65	and	and	CC
cord-015684-q10sx1dm	12	66	38	38	CD
cord-015684-q10sx1dm	12	67	%	%	NN
cord-015684-q10sx1dm	12	68	of	of	IN
cord-015684-q10sx1dm	12	69	CYP3A4	CYP3A4	NNP
cord-015684-q10sx1dm	12	70	;	;	:
cord-015684-q10sx1dm	12	71	7	7	CD
cord-015684-q10sx1dm	12	72	%	%	NN
cord-015684-q10sx1dm	12	73	of	of	IN
cord-015684-q10sx1dm	12	74	benzodiazepines	benzodiazepine	NNS
cord-015684-q10sx1dm	12	75	are	be	VBP
cord-015684-q10sx1dm	12	76	major	major	JJ
cord-015684-q10sx1dm	12	77	substrates	substrate	NNS
cord-015684-q10sx1dm	12	78	of	of	IN
cord-015684-q10sx1dm	12	79	CYP2C19	CYP2C19	NNP
cord-015684-q10sx1dm	12	80	enzymes	enzyme	NNS
cord-015684-q10sx1dm	12	81	,	,	,
cord-015684-q10sx1dm	12	82	20	20	CD
cord-015684-q10sx1dm	12	83	%	%	NN
cord-015684-q10sx1dm	12	84	of	of	IN
cord-015684-q10sx1dm	12	85	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	12	86	,	,	,
cord-015684-q10sx1dm	12	87	and	and	CC
cord-015684-q10sx1dm	12	88	95	95	CD
cord-015684-q10sx1dm	12	89	%	%	NN
cord-015684-q10sx1dm	12	90	of	of	IN
cord-015684-q10sx1dm	12	91	CYP3A4	CYP3A4	NNP
cord-015684-q10sx1dm	12	92	.	.	.
cord-015684-q10sx1dm	13	1	About	about	RB
cord-015684-q10sx1dm	13	2	10–20	10–20	CD
cord-015684-q10sx1dm	13	3	%	%	NN
cord-015684-q10sx1dm	13	4	of	of	IN
cord-015684-q10sx1dm	13	5	Caucasians	Caucasians	NNPS
cord-015684-q10sx1dm	13	6	are	be	VBP
cord-015684-q10sx1dm	13	7	carriers	carrier	NNS
cord-015684-q10sx1dm	13	8	of	of	IN
cord-015684-q10sx1dm	13	9	defective	defective	JJ
cord-015684-q10sx1dm	13	10	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	13	11	polymorphic	polymorphic	JJ
cord-015684-q10sx1dm	13	12	variants	variant	NNS
cord-015684-q10sx1dm	13	13	that	that	WDT
cord-015684-q10sx1dm	13	14	alter	alter	VBP
cord-015684-q10sx1dm	13	15	the	the	DT
cord-015684-q10sx1dm	13	16	metabolism	metabolism	NN
cord-015684-q10sx1dm	13	17	of	of	IN
cord-015684-q10sx1dm	13	18	many	many	JJ
cord-015684-q10sx1dm	13	19	psychotropic	psychotropic	JJ
cord-015684-q10sx1dm	13	20	agents	agent	NNS
cord-015684-q10sx1dm	13	21	.	.	.
cord-015684-q10sx1dm	14	1	Other	other	JJ
cord-015684-q10sx1dm	14	2	100	100	CD
cord-015684-q10sx1dm	14	3	genes	gene	NNS
cord-015684-q10sx1dm	14	4	participate	participate	VBP
cord-015684-q10sx1dm	14	5	in	in	IN
cord-015684-q10sx1dm	14	6	the	the	DT
cord-015684-q10sx1dm	14	7	efficacy	efficacy	NN
cord-015684-q10sx1dm	14	8	and	and	CC
cord-015684-q10sx1dm	14	9	safety	safety	NN
cord-015684-q10sx1dm	14	10	of	of	IN
cord-015684-q10sx1dm	14	11	psychotropic	psychotropic	JJ
cord-015684-q10sx1dm	14	12	drugs	drug	NNS
cord-015684-q10sx1dm	14	13	.	.	.
cord-015684-q10sx1dm	15	1	The	the	DT
cord-015684-q10sx1dm	15	2	incorporation	incorporation	NN
cord-015684-q10sx1dm	15	3	of	of	IN
cord-015684-q10sx1dm	15	4	pharmacogenetic/	pharmacogenetic/	CD
cord-015684-q10sx1dm	15	5	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	15	6	protocols	protocol	NNS
cord-015684-q10sx1dm	15	7	to	to	IN
cord-015684-q10sx1dm	15	8	CNS	CNS	NNP
cord-015684-q10sx1dm	15	9	research	research	NN
cord-015684-q10sx1dm	15	10	and	and	CC
cord-015684-q10sx1dm	15	11	clinical	clinical	JJ
cord-015684-q10sx1dm	15	12	practice	practice	NN
cord-015684-q10sx1dm	15	13	can	can	MD
cord-015684-q10sx1dm	15	14	foster	foster	VB
cord-015684-q10sx1dm	15	15	therapeutics	therapeutics	NN
cord-015684-q10sx1dm	15	16	optimization	optimization	NN
cord-015684-q10sx1dm	15	17	by	by	IN
cord-015684-q10sx1dm	15	18	helping	help	VBG
cord-015684-q10sx1dm	15	19	to	to	TO
cord-015684-q10sx1dm	15	20	develop	develop	VB
cord-015684-q10sx1dm	15	21	cost	cost	NN
cord-015684-q10sx1dm	15	22	-	-	HYPH
cord-015684-q10sx1dm	15	23	effective	effective	JJ
cord-015684-q10sx1dm	15	24	pharmaceuticals	pharmaceutical	NNS
cord-015684-q10sx1dm	15	25	and	and	CC
cord-015684-q10sx1dm	15	26	improving	improve	VBG
cord-015684-q10sx1dm	15	27	drug	drug	NN
cord-015684-q10sx1dm	15	28	efficacy	efficacy	NN
cord-015684-q10sx1dm	15	29	and	and	CC
cord-015684-q10sx1dm	15	30	safety	safety	NN
cord-015684-q10sx1dm	15	31	.	.	.
cord-015684-q10sx1dm	16	1	To	to	TO
cord-015684-q10sx1dm	16	2	achieve	achieve	VB
cord-015684-q10sx1dm	16	3	this	this	DT
cord-015684-q10sx1dm	16	4	goal	goal	NN
cord-015684-q10sx1dm	16	5	several	several	JJ
cord-015684-q10sx1dm	16	6	measures	measure	NNS
cord-015684-q10sx1dm	16	7	have	have	VBP
cord-015684-q10sx1dm	16	8	to	to	TO
cord-015684-q10sx1dm	16	9	be	be	VB
cord-015684-q10sx1dm	16	10	taken	take	VBN
cord-015684-q10sx1dm	16	11	,	,	,
cord-015684-q10sx1dm	16	12	including	include	VBG
cord-015684-q10sx1dm	16	13	:	:	:
cord-015684-q10sx1dm	16	14	(	(	-LRB-
cord-015684-q10sx1dm	16	15	a	a	LS
cord-015684-q10sx1dm	16	16	)	)	-RRB-
cord-015684-q10sx1dm	16	17	educate	educate	VBP
cord-015684-q10sx1dm	16	18	physicians	physician	NNS
cord-015684-q10sx1dm	16	19	and	and	CC
cord-015684-q10sx1dm	16	20	the	the	DT
cord-015684-q10sx1dm	16	21	public	public	NN
cord-015684-q10sx1dm	16	22	on	on	IN
cord-015684-q10sx1dm	16	23	the	the	DT
cord-015684-q10sx1dm	16	24	use	use	NN
cord-015684-q10sx1dm	16	25	of	of	IN
cord-015684-q10sx1dm	16	26	genetic/	genetic/	CD
cord-015684-q10sx1dm	16	27	genomic	genomic	JJ
cord-015684-q10sx1dm	16	28	screening	screening	NN
cord-015684-q10sx1dm	16	29	in	in	IN
cord-015684-q10sx1dm	16	30	the	the	DT
cord-015684-q10sx1dm	16	31	daily	daily	JJ
cord-015684-q10sx1dm	16	32	clinical	clinical	JJ
cord-015684-q10sx1dm	16	33	practice	practice	NN
cord-015684-q10sx1dm	16	34	;	;	,
cord-015684-q10sx1dm	16	35	(	(	-LRB-
cord-015684-q10sx1dm	16	36	b	b	NN
cord-015684-q10sx1dm	16	37	)	)	-RRB-
cord-015684-q10sx1dm	16	38	standardize	standardize	VB
cord-015684-q10sx1dm	16	39	genetic	genetic	JJ
cord-015684-q10sx1dm	16	40	testing	testing	NN
cord-015684-q10sx1dm	16	41	for	for	IN
cord-015684-q10sx1dm	16	42	major	major	JJ
cord-015684-q10sx1dm	16	43	categories	category	NNS
cord-015684-q10sx1dm	16	44	of	of	IN
cord-015684-q10sx1dm	16	45	drugs	drug	NNS
cord-015684-q10sx1dm	16	46	;	;	,
cord-015684-q10sx1dm	16	47	(	(	-LRB-
cord-015684-q10sx1dm	16	48	c	c	NN
cord-015684-q10sx1dm	16	49	)	)	-RRB-
cord-015684-q10sx1dm	16	50	validate	validate	VB
cord-015684-q10sx1dm	16	51	pharmacogenetic	pharmacogenetic	JJ
cord-015684-q10sx1dm	16	52	and	and	CC
cord-015684-q10sx1dm	16	53	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	16	54	procedures	procedure	NNS
cord-015684-q10sx1dm	16	55	according	accord	VBG
cord-015684-q10sx1dm	16	56	to	to	IN
cord-015684-q10sx1dm	16	57	drug	drug	NN
cord-015684-q10sx1dm	16	58	category	category	NN
cord-015684-q10sx1dm	16	59	and	and	CC
cord-015684-q10sx1dm	16	60	pathology	pathology	NN
cord-015684-q10sx1dm	16	61	;	;	,
cord-015684-q10sx1dm	16	62	(	(	-LRB-
cord-015684-q10sx1dm	16	63	d	d	LS
cord-015684-q10sx1dm	16	64	)	)	-RRB-
cord-015684-q10sx1dm	16	65	regulate	regulate	VB
cord-015684-q10sx1dm	16	66	ethical	ethical	JJ
cord-015684-q10sx1dm	16	67	,	,	,
cord-015684-q10sx1dm	16	68	social	social	JJ
cord-015684-q10sx1dm	16	69	,	,	,
cord-015684-q10sx1dm	16	70	and	and	CC
cord-015684-q10sx1dm	16	71	economic	economic	JJ
cord-015684-q10sx1dm	16	72	issues	issue	NNS
cord-015684-q10sx1dm	16	73	;	;	:
cord-015684-q10sx1dm	16	74	and	and	CC
cord-015684-q10sx1dm	16	75	(	(	-LRB-
cord-015684-q10sx1dm	16	76	e	e	LS
cord-015684-q10sx1dm	16	77	)	)	-RRB-
cord-015684-q10sx1dm	16	78	incorporate	incorporate	VB
cord-015684-q10sx1dm	16	79	pharmacogenetic	pharmacogenetic	NN
cord-015684-q10sx1dm	16	80	and	and	CC
cord-015684-q10sx1dm	16	81	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	16	82	procedures	procedure	NNS
cord-015684-q10sx1dm	16	83	to	to	IN
cord-015684-q10sx1dm	16	84	both	both	DT
cord-015684-q10sx1dm	16	85	drugs	drug	NNS
cord-015684-q10sx1dm	16	86	in	in	IN
cord-015684-q10sx1dm	16	87	development	development	NN
cord-015684-q10sx1dm	16	88	and	and	CC
cord-015684-q10sx1dm	16	89	drugs	drug	NNS
cord-015684-q10sx1dm	16	90	in	in	IN
cord-015684-q10sx1dm	16	91	the	the	DT
cord-015684-q10sx1dm	16	92	market	market	NN
cord-015684-q10sx1dm	16	93	to	to	TO
cord-015684-q10sx1dm	16	94	optimize	optimize	VB
cord-015684-q10sx1dm	16	95	therapeutics	therapeutic	NNS
cord-015684-q10sx1dm	16	96	.	.	.
cord-015684-q10sx1dm	17	1	Central	central	JJ
cord-015684-q10sx1dm	17	2	nervous	nervous	JJ
cord-015684-q10sx1dm	17	3	system	system	NN
cord-015684-q10sx1dm	17	4	(	(	-LRB-
cord-015684-q10sx1dm	17	5	CNS	CNS	NNP
cord-015684-q10sx1dm	17	6	)	)	-RRB-
cord-015684-q10sx1dm	17	7	disorders	disorder	NNS
cord-015684-q10sx1dm	17	8	are	be	VBP
cord-015684-q10sx1dm	17	9	the	the	DT
cord-015684-q10sx1dm	17	10	third	third	JJ
cord-015684-q10sx1dm	17	11	problem	problem	NN
cord-015684-q10sx1dm	17	12	of	of	IN
cord-015684-q10sx1dm	17	13	health	health	NN
cord-015684-q10sx1dm	17	14	in	in	IN
cord-015684-q10sx1dm	17	15	developed	develop	VBN
cord-015684-q10sx1dm	17	16	countries	country	NNS
cord-015684-q10sx1dm	17	17	,	,	,
cord-015684-q10sx1dm	17	18	representing	represent	VBG
cord-015684-q10sx1dm	17	19	10	10	CD
cord-015684-q10sx1dm	17	20	-	-	SYM
cord-015684-q10sx1dm	17	21	15	15	CD
cord-015684-q10sx1dm	17	22	%	%	NN
cord-015684-q10sx1dm	17	23	of	of	IN
cord-015684-q10sx1dm	17	24	deaths	death	NNS
cord-015684-q10sx1dm	17	25	,	,	,
cord-015684-q10sx1dm	17	26	after	after	IN
cord-015684-q10sx1dm	17	27	cardiovascular	cardiovascular	JJ
cord-015684-q10sx1dm	17	28	disorders	disorder	NNS
cord-015684-q10sx1dm	17	29	(	(	-LRB-
cord-015684-q10sx1dm	17	30	25	25	CD
cord-015684-q10sx1dm	17	31	-	-	SYM
cord-015684-q10sx1dm	17	32	30	30	CD
cord-015684-q10sx1dm	17	33	%	%	NN
cord-015684-q10sx1dm	17	34	)	)	-RRB-
cord-015684-q10sx1dm	17	35	and	and	CC
cord-015684-q10sx1dm	17	36	cancer	cancer	NN
cord-015684-q10sx1dm	17	37	(	(	-LRB-
cord-015684-q10sx1dm	17	38	20	20	CD
cord-015684-q10sx1dm	17	39	-	-	SYM
cord-015684-q10sx1dm	17	40	25	25	CD
cord-015684-q10sx1dm	17	41	%	%	NN
cord-015684-q10sx1dm	17	42	)	)	-RRB-
cord-015684-q10sx1dm	17	43	.	.	.
cord-015684-q10sx1dm	18	1	Approximately	approximately	RB
cord-015684-q10sx1dm	18	2	,	,	,
cord-015684-q10sx1dm	18	3	127	127	CD
cord-015684-q10sx1dm	18	4	million	million	CD
cord-015684-q10sx1dm	18	5	Europeans	Europeans	NNPS
cord-015684-q10sx1dm	18	6	suffer	suffer	VBP
cord-015684-q10sx1dm	18	7	brain	brain	NN
cord-015684-q10sx1dm	18	8	disorders	disorder	NNS
cord-015684-q10sx1dm	18	9	.	.	.
cord-015684-q10sx1dm	19	1	The	the	DT
cord-015684-q10sx1dm	19	2	total	total	JJ
cord-015684-q10sx1dm	19	3	annual	annual	JJ
cord-015684-q10sx1dm	19	4	cost	cost	NN
cord-015684-q10sx1dm	19	5	of	of	IN
cord-015684-q10sx1dm	19	6	brain	brain	NN
cord-015684-q10sx1dm	19	7	disorders	disorder	NNS
cord-015684-q10sx1dm	19	8	in	in	IN
cord-015684-q10sx1dm	19	9	Europe	Europe	NNP
cord-015684-q10sx1dm	19	10	is	be	VBZ
cord-015684-q10sx1dm	19	11	about	about	RB
cord-015684-q10sx1dm	19	12	€	€	$
cord-015684-q10sx1dm	19	13	386	386	CD
cord-015684-q10sx1dm	19	14	billion	billion	CD
cord-015684-q10sx1dm	19	15	,	,	,
cord-015684-q10sx1dm	19	16	with	with	IN
cord-015684-q10sx1dm	19	17	€	€	$
cord-015684-q10sx1dm	19	18	135	135	CD
cord-015684-q10sx1dm	19	19	billion	billion	CD
cord-015684-q10sx1dm	19	20	of	of	IN
cord-015684-q10sx1dm	19	21	direct	direct	JJ
cord-015684-q10sx1dm	19	22	medical	medical	JJ
cord-015684-q10sx1dm	19	23	expenditures	expenditure	NNS
cord-015684-q10sx1dm	19	24	(	(	-LRB-
cord-015684-q10sx1dm	19	25	€	€	$
cord-015684-q10sx1dm	19	26	78	78	CD
cord-015684-q10sx1dm	19	27	billion	billion	CD
cord-015684-q10sx1dm	19	28	,	,	,
cord-015684-q10sx1dm	19	29	inpatients	inpatient	NNS
cord-015684-q10sx1dm	19	30	;	;	:
cord-015684-q10sx1dm	19	31	€	€	$
cord-015684-q10sx1dm	19	32	45	45	CD
cord-015684-q10sx1dm	19	33	billion	billion	CD
cord-015684-q10sx1dm	19	34	,	,	,
cord-015684-q10sx1dm	19	35	outpatients	outpatient	NNS
cord-015684-q10sx1dm	19	36	;	;	:
cord-015684-q10sx1dm	19	37	€	€	$
cord-015684-q10sx1dm	19	38	13	13	CD
cord-015684-q10sx1dm	19	39	billion	billion	CD
cord-015684-q10sx1dm	19	40	,	,	,
cord-015684-q10sx1dm	19	41	pharmacological	pharmacological	JJ
cord-015684-q10sx1dm	19	42	treatment	treatment	NN
cord-015684-q10sx1dm	19	43	)	)	-RRB-
cord-015684-q10sx1dm	19	44	,	,	,
cord-015684-q10sx1dm	19	45	€	€	$
cord-015684-q10sx1dm	19	46	179	179	CD
cord-015684-q10sx1dm	19	47	billion	billion	CD
cord-015684-q10sx1dm	19	48	of	of	IN
cord-015684-q10sx1dm	19	49	indirect	indirect	JJ
cord-015684-q10sx1dm	19	50	costs	cost	NNS
cord-015684-q10sx1dm	19	51	(	(	-LRB-
cord-015684-q10sx1dm	19	52	lost	lose	VBN
cord-015684-q10sx1dm	19	53	workdays	workday	NNS
cord-015684-q10sx1dm	19	54	,	,	,
cord-015684-q10sx1dm	19	55	productivity	productivity	NN
cord-015684-q10sx1dm	19	56	loss	loss	NN
cord-015684-q10sx1dm	19	57	,	,	,
cord-015684-q10sx1dm	19	58	permanent	permanent	JJ
cord-015684-q10sx1dm	19	59	disability	disability	NN
cord-015684-q10sx1dm	19	60	)	)	-RRB-
cord-015684-q10sx1dm	19	61	,	,	,
cord-015684-q10sx1dm	19	62	and	and	CC
cord-015684-q10sx1dm	19	63	€	€	$
cord-015684-q10sx1dm	19	64	72	72	CD
cord-015684-q10sx1dm	19	65	billion	billion	CD
cord-015684-q10sx1dm	19	66	of	of	IN
cord-015684-q10sx1dm	19	67	direct	direct	JJ
cord-015684-q10sx1dm	19	68	non	non	JJ
cord-015684-q10sx1dm	19	69	-	-	JJ
cord-015684-q10sx1dm	19	70	medical	medical	JJ
cord-015684-q10sx1dm	19	71	costs	cost	NNS
cord-015684-q10sx1dm	19	72	.	.	.
cord-015684-q10sx1dm	20	1	Mental	mental	JJ
cord-015684-q10sx1dm	20	2	disorders	disorder	NNS
cord-015684-q10sx1dm	20	3	represent	represent	VBP
cord-015684-q10sx1dm	20	4	€	€	$
cord-015684-q10sx1dm	20	5	240	240	CD
cord-015684-q10sx1dm	20	6	billion	billion	CD
cord-015684-q10sx1dm	20	7	(	(	-LRB-
cord-015684-q10sx1dm	20	8	62	62	CD
cord-015684-q10sx1dm	20	9	%	%	NN
cord-015684-q10sx1dm	20	10	of	of	IN
cord-015684-q10sx1dm	20	11	the	the	DT
cord-015684-q10sx1dm	20	12	total	total	JJ
cord-015684-q10sx1dm	20	13	cost	cost	NN
cord-015684-q10sx1dm	20	14	,	,	,
cord-015684-q10sx1dm	20	15	excluding	exclude	VBG
cord-015684-q10sx1dm	20	16	dementia	dementia	NN
cord-015684-q10sx1dm	20	17	)	)	-RRB-
cord-015684-q10sx1dm	20	18	,	,	,
cord-015684-q10sx1dm	20	19	followed	follow	VBN
cord-015684-q10sx1dm	20	20	by	by	IN
cord-015684-q10sx1dm	20	21	neurological	neurological	JJ
cord-015684-q10sx1dm	20	22	diseases	disease	NNS
cord-015684-q10sx1dm	20	23	(	(	-LRB-
cord-015684-q10sx1dm	20	24	€	€	$
cord-015684-q10sx1dm	20	25	84	84	CD
cord-015684-q10sx1dm	20	26	billion	billion	CD
cord-015684-q10sx1dm	20	27	,	,	,
cord-015684-q10sx1dm	20	28	22	22	CD
cord-015684-q10sx1dm	20	29	%	%	NN
cord-015684-q10sx1dm	20	30	)	)	-RRB-
cord-015684-q10sx1dm	20	31	.	.	.
cord-015684-q10sx1dm	21	1	1	1	LS
cord-015684-q10sx1dm	21	2	Senile	senile	JJ
cord-015684-q10sx1dm	21	3	dementia	dementia	NN
cord-015684-q10sx1dm	21	4	is	be	VBZ
cord-015684-q10sx1dm	21	5	becoming	become	VBG
cord-015684-q10sx1dm	21	6	a	a	DT
cord-015684-q10sx1dm	21	7	major	major	JJ
cord-015684-q10sx1dm	21	8	problem	problem	NN
cord-015684-q10sx1dm	21	9	of	of	IN
cord-015684-q10sx1dm	21	10	health	health	NN
cord-015684-q10sx1dm	21	11	in	in	IN
cord-015684-q10sx1dm	21	12	developed	develop	VBN
cord-015684-q10sx1dm	21	13	countries	country	NNS
cord-015684-q10sx1dm	21	14	,	,	,
cord-015684-q10sx1dm	21	15	and	and	CC
cord-015684-q10sx1dm	21	16	the	the	DT
cord-015684-q10sx1dm	21	17	primary	primary	JJ
cord-015684-q10sx1dm	21	18	cause	cause	NN
cord-015684-q10sx1dm	21	19	of	of	IN
cord-015684-q10sx1dm	21	20	disability	disability	NN
cord-015684-q10sx1dm	21	21	in	in	IN
cord-015684-q10sx1dm	21	22	the	the	DT
cord-015684-q10sx1dm	21	23	elderly	elderly	JJ
cord-015684-q10sx1dm	21	24	.	.	.
cord-015684-q10sx1dm	22	1	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	22	2	's	's	POS
cord-015684-q10sx1dm	22	3	disease	disease	NN
cord-015684-q10sx1dm	22	4	(	(	-LRB-
cord-015684-q10sx1dm	22	5	AD	ad	NN
cord-015684-q10sx1dm	22	6	)	)	-RRB-
cord-015684-q10sx1dm	22	7	is	be	VBZ
cord-015684-q10sx1dm	22	8	the	the	DT
cord-015684-q10sx1dm	22	9	most	most	RBS
cord-015684-q10sx1dm	22	10	frequent	frequent	JJ
cord-015684-q10sx1dm	22	11	form	form	NN
cord-015684-q10sx1dm	22	12	of	of	IN
cord-015684-q10sx1dm	22	13	dementia	dementia	NN
cord-015684-q10sx1dm	22	14	(	(	-LRB-
cord-015684-q10sx1dm	22	15	50	50	CD
cord-015684-q10sx1dm	22	16	-	-	SYM
cord-015684-q10sx1dm	22	17	70	70	CD
cord-015684-q10sx1dm	22	18	%	%	NN
cord-015684-q10sx1dm	22	19	)	)	-RRB-
cord-015684-q10sx1dm	22	20	,	,	,
cord-015684-q10sx1dm	22	21	followed	follow	VBN
cord-015684-q10sx1dm	22	22	by	by	IN
cord-015684-q10sx1dm	22	23	vascular	vascular	JJ
cord-015684-q10sx1dm	22	24	dementia	dementia	NN
cord-015684-q10sx1dm	22	25	(	(	-LRB-
cord-015684-q10sx1dm	22	26	30	30	CD
cord-015684-q10sx1dm	22	27	-	-	SYM
cord-015684-q10sx1dm	22	28	40	40	CD
cord-015684-q10sx1dm	22	29	%	%	NN
cord-015684-q10sx1dm	22	30	)	)	-RRB-
cord-015684-q10sx1dm	22	31	,	,	,
cord-015684-q10sx1dm	22	32	and	and	CC
cord-015684-q10sx1dm	22	33	mixed	mixed	JJ
cord-015684-q10sx1dm	22	34	dementia	dementia	NN
cord-015684-q10sx1dm	22	35	(	(	-LRB-
cord-015684-q10sx1dm	22	36	15	15	CD
cord-015684-q10sx1dm	22	37	-	-	SYM
cord-015684-q10sx1dm	22	38	20	20	CD
cord-015684-q10sx1dm	22	39	%	%	NN
cord-015684-q10sx1dm	22	40	)	)	-RRB-
cord-015684-q10sx1dm	22	41	.	.	.
cord-015684-q10sx1dm	23	1	These	these	DT
cord-015684-q10sx1dm	23	2	prevalent	prevalent	JJ
cord-015684-q10sx1dm	23	3	forms	form	NNS
cord-015684-q10sx1dm	23	4	of	of	IN
cord-015684-q10sx1dm	23	5	agerelated	agerelate	VBN
cord-015684-q10sx1dm	23	6	neurodegeneration	neurodegeneration	NN
cord-015684-q10sx1dm	23	7	affect	affect	VBP
cord-015684-q10sx1dm	23	8	more	more	JJR
cord-015684-q10sx1dm	23	9	than	than	IN
cord-015684-q10sx1dm	23	10	25	25	CD
cord-015684-q10sx1dm	23	11	million	million	CD
cord-015684-q10sx1dm	23	12	people	people	NNS
cord-015684-q10sx1dm	23	13	at	at	IN
cord-015684-q10sx1dm	23	14	present	present	NN
cord-015684-q10sx1dm	23	15	,	,	,
cord-015684-q10sx1dm	23	16	and	and	CC
cord-015684-q10sx1dm	23	17	probably	probably	RB
cord-015684-q10sx1dm	23	18	more	more	JJR
cord-015684-q10sx1dm	23	19	than	than	IN
cord-015684-q10sx1dm	23	20	75	75	CD
cord-015684-q10sx1dm	23	21	million	million	CD
cord-015684-q10sx1dm	23	22	people	people	NNS
cord-015684-q10sx1dm	23	23	will	will	MD
cord-015684-q10sx1dm	23	24	be	be	VB
cord-015684-q10sx1dm	23	25	at	at	IN
cord-015684-q10sx1dm	23	26	risk	risk	NN
cord-015684-q10sx1dm	23	27	in	in	IN
cord-015684-q10sx1dm	23	28	the	the	DT
cord-015684-q10sx1dm	23	29	next	next	JJ
cord-015684-q10sx1dm	23	30	20	20	CD
cord-015684-q10sx1dm	23	31	-	-	SYM
cord-015684-q10sx1dm	23	32	25	25	CD
cord-015684-q10sx1dm	23	33	years	year	NNS
cord-015684-q10sx1dm	23	34	worldwide	worldwide	RB
cord-015684-q10sx1dm	23	35	.	.	.
cord-015684-q10sx1dm	24	1	The	the	DT
cord-015684-q10sx1dm	24	2	prevalence	prevalence	NN
cord-015684-q10sx1dm	24	3	of	of	IN
cord-015684-q10sx1dm	24	4	dementia	dementia	NN
cord-015684-q10sx1dm	24	5	increases	increase	NNS
cord-015684-q10sx1dm	24	6	exponentially	exponentially	RB
cord-015684-q10sx1dm	24	7	from	from	IN
cord-015684-q10sx1dm	24	8	approximately	approximately	RB
cord-015684-q10sx1dm	24	9	1	1	CD
cord-015684-q10sx1dm	24	10	%	%	NN
cord-015684-q10sx1dm	24	11	at	at	IN
cord-015684-q10sx1dm	24	12	60	60	CD
cord-015684-q10sx1dm	24	13	-	-	SYM
cord-015684-q10sx1dm	24	14	65	65	CD
cord-015684-q10sx1dm	24	15	years	year	NNS
cord-015684-q10sx1dm	24	16	of	of	IN
cord-015684-q10sx1dm	24	17	age	age	NN
cord-015684-q10sx1dm	24	18	to	to	IN
cord-015684-q10sx1dm	24	19	more	more	JJR
cord-015684-q10sx1dm	24	20	than	than	IN
cord-015684-q10sx1dm	24	21	30	30	CD
cord-015684-q10sx1dm	24	22	-	-	SYM
cord-015684-q10sx1dm	24	23	35	35	CD
cord-015684-q10sx1dm	24	24	%	%	NN
cord-015684-q10sx1dm	24	25	in	in	IN
cord-015684-q10sx1dm	24	26	people	people	NNS
cord-015684-q10sx1dm	24	27	older	old	JJR
cord-015684-q10sx1dm	24	28	than	than	IN
cord-015684-q10sx1dm	24	29	80	80	CD
cord-015684-q10sx1dm	24	30	years	year	NNS
cord-015684-q10sx1dm	24	31	.	.	.
cord-015684-q10sx1dm	25	1	It	-PRON-	PRP
cord-015684-q10sx1dm	25	2	is	be	VBZ
cord-015684-q10sx1dm	25	3	very	very	RB
cord-015684-q10sx1dm	25	4	likely	likely	JJ
cord-015684-q10sx1dm	25	5	that	that	IN
cord-015684-q10sx1dm	25	6	in	in	IN
cord-015684-q10sx1dm	25	7	those	those	DT
cord-015684-q10sx1dm	25	8	patients	patient	NNS
cord-015684-q10sx1dm	25	9	older	old	JJR
cord-015684-q10sx1dm	25	10	than	than	IN
cord-015684-q10sx1dm	25	11	75	75	CD
cord-015684-q10sx1dm	25	12	-	-	SYM
cord-015684-q10sx1dm	25	13	80	80	CD
cord-015684-q10sx1dm	25	14	years	year	NNS
cord-015684-q10sx1dm	25	15	of	of	IN
cord-015684-q10sx1dm	25	16	age	age	NN
cord-015684-q10sx1dm	25	17	most	most	JJS
cord-015684-q10sx1dm	25	18	cases	case	NNS
cord-015684-q10sx1dm	25	19	of	of	IN
cord-015684-q10sx1dm	25	20	dementia	dementia	NN
cord-015684-q10sx1dm	25	21	are	be	VBP
cord-015684-q10sx1dm	25	22	mixed	mix	VBN
cord-015684-q10sx1dm	25	23	in	in	IN
cord-015684-q10sx1dm	25	24	nature	nature	NN
cord-015684-q10sx1dm	25	25	(	(	-LRB-
cord-015684-q10sx1dm	25	26	degenerative	degenerative	JJ
cord-015684-q10sx1dm	25	27	+	+	CC
cord-015684-q10sx1dm	25	28	vascular	vascular	JJ
cord-015684-q10sx1dm	25	29	)	)	-RRB-
cord-015684-q10sx1dm	25	30	,	,	,
cord-015684-q10sx1dm	25	31	whereas	whereas	IN
cord-015684-q10sx1dm	25	32	pure	pure	JJ
cord-015684-q10sx1dm	25	33	AD	ad	NN
cord-015684-q10sx1dm	25	34	cases	case	NNS
cord-015684-q10sx1dm	25	35	are	be	VBP
cord-015684-q10sx1dm	25	36	very	very	RB
cord-015684-q10sx1dm	25	37	rare	rare	JJ
cord-015684-q10sx1dm	25	38	after	after	IN
cord-015684-q10sx1dm	25	39	80	80	CD
cord-015684-q10sx1dm	25	40	years	year	NNS
cord-015684-q10sx1dm	25	41	of	of	IN
cord-015684-q10sx1dm	25	42	age	age	NN
cord-015684-q10sx1dm	25	43	.	.	.
cord-015684-q10sx1dm	26	1	The	the	DT
cord-015684-q10sx1dm	26	2	average	average	JJ
cord-015684-q10sx1dm	26	3	annual	annual	JJ
cord-015684-q10sx1dm	26	4	cost	cost	NN
cord-015684-q10sx1dm	26	5	per	per	IN
cord-015684-q10sx1dm	26	6	person	person	NN
cord-015684-q10sx1dm	26	7	with	with	IN
cord-015684-q10sx1dm	26	8	dementia	dementia	NN
cord-015684-q10sx1dm	26	9	ranges	range	NNS
cord-015684-q10sx1dm	26	10	from	from	IN
cord-015684-q10sx1dm	26	11	€	€	$
cord-015684-q10sx1dm	26	12	10,000	10,000	CD
cord-015684-q10sx1dm	26	13	to	to	IN
cord-015684-q10sx1dm	26	14	40,000	40,000	CD
cord-015684-q10sx1dm	26	15	,	,	,
cord-015684-q10sx1dm	26	16	depending	depend	VBG
cord-015684-q10sx1dm	26	17	upon	upon	IN
cord-015684-q10sx1dm	26	18	disease	disease	NN
cord-015684-q10sx1dm	26	19	stage	stage	NN
cord-015684-q10sx1dm	26	20	and	and	CC
cord-015684-q10sx1dm	26	21	country	country	NN
cord-015684-q10sx1dm	26	22	,	,	,
cord-015684-q10sx1dm	26	23	with	with	IN
cord-015684-q10sx1dm	26	24	a	a	DT
cord-015684-q10sx1dm	26	25	lifetime	lifetime	NN
cord-015684-q10sx1dm	26	26	cost	cost	NN
cord-015684-q10sx1dm	26	27	per	per	IN
cord-015684-q10sx1dm	26	28	patient	patient	NN
cord-015684-q10sx1dm	26	29	of	of	IN
cord-015684-q10sx1dm	26	30	more	more	JJR
cord-015684-q10sx1dm	26	31	than	than	IN
cord-015684-q10sx1dm	26	32	€	€	$
cord-015684-q10sx1dm	26	33	150,000	150,000	CD
cord-015684-q10sx1dm	26	34	.	.	.
cord-015684-q10sx1dm	27	1	In	in	IN
cord-015684-q10sx1dm	27	2	some	some	DT
cord-015684-q10sx1dm	27	3	countries	country	NNS
cord-015684-q10sx1dm	27	4	,	,	,
cord-015684-q10sx1dm	27	5	approximately	approximately	RB
cord-015684-q10sx1dm	27	6	80	80	CD
cord-015684-q10sx1dm	27	7	%	%	NN
cord-015684-q10sx1dm	27	8	of	of	IN
cord-015684-q10sx1dm	27	9	the	the	DT
cord-015684-q10sx1dm	27	10	global	global	JJ
cord-015684-q10sx1dm	27	11	costs	cost	NNS
cord-015684-q10sx1dm	27	12	of	of	IN
cord-015684-q10sx1dm	27	13	dementia	dementia	NN
cord-015684-q10sx1dm	27	14	(	(	-LRB-
cord-015684-q10sx1dm	27	15	direct	direct	JJ
cord-015684-q10sx1dm	27	16	+	+	CC
cord-015684-q10sx1dm	27	17	indirect	indirect	JJ
cord-015684-q10sx1dm	27	18	costs	cost	NNS
cord-015684-q10sx1dm	27	19	)	)	-RRB-
cord-015684-q10sx1dm	27	20	are	be	VBP
cord-015684-q10sx1dm	27	21	assumed	assume	VBN
cord-015684-q10sx1dm	27	22	by	by	IN
cord-015684-q10sx1dm	27	23	the	the	DT
cord-015684-q10sx1dm	27	24	patients	patient	NNS
cord-015684-q10sx1dm	27	25	and/or	and/or	CC
cord-015684-q10sx1dm	27	26	their	-PRON-	PRP$
cord-015684-q10sx1dm	27	27	families	family	NNS
cord-015684-q10sx1dm	27	28	.	.	.
cord-015684-q10sx1dm	28	1	About	about	RB
cord-015684-q10sx1dm	28	2	10	10	CD
cord-015684-q10sx1dm	28	3	-	-	SYM
cord-015684-q10sx1dm	28	4	20	20	CD
cord-015684-q10sx1dm	28	5	%	%	NN
cord-015684-q10sx1dm	28	6	of	of	IN
cord-015684-q10sx1dm	28	7	the	the	DT
cord-015684-q10sx1dm	28	8	costs	cost	NNS
cord-015684-q10sx1dm	28	9	in	in	IN
cord-015684-q10sx1dm	28	10	dementia	dementia	NN
cord-015684-q10sx1dm	28	11	are	be	VBP
cord-015684-q10sx1dm	28	12	attributed	attribute	VBN
cord-015684-q10sx1dm	28	13	to	to	IN
cord-015684-q10sx1dm	28	14	pharmacological	pharmacological	JJ
cord-015684-q10sx1dm	28	15	treatment	treatment	NN
cord-015684-q10sx1dm	28	16	,	,	,
cord-015684-q10sx1dm	28	17	including	include	VBG
cord-015684-q10sx1dm	28	18	anti	anti	JJ
cord-015684-q10sx1dm	28	19	-	-	JJ
cord-015684-q10sx1dm	28	20	dementia	dementia	JJ
cord-015684-q10sx1dm	28	21	drugs	drug	NNS
cord-015684-q10sx1dm	28	22	,	,	,
cord-015684-q10sx1dm	28	23	psychotropics	psychotropic	NNS
cord-015684-q10sx1dm	28	24	(	(	-LRB-
cord-015684-q10sx1dm	28	25	antidepressants	antidepressant	NNS
cord-015684-q10sx1dm	28	26	,	,	,
cord-015684-q10sx1dm	28	27	neuroleptics	neuroleptic	NNS
cord-015684-q10sx1dm	28	28	,	,	,
cord-015684-q10sx1dm	28	29	anxiolytics	anxiolytic	NNS
cord-015684-q10sx1dm	28	30	)	)	-RRB-
cord-015684-q10sx1dm	28	31	,	,	,
cord-015684-q10sx1dm	28	32	and	and	CC
cord-015684-q10sx1dm	28	33	other	other	JJ
cord-015684-q10sx1dm	28	34	drugs	drug	NNS
cord-015684-q10sx1dm	28	35	currently	currently	RB
cord-015684-q10sx1dm	28	36	prescribed	prescribe	VBN
cord-015684-q10sx1dm	28	37	in	in	IN
cord-015684-q10sx1dm	28	38	the	the	DT
cord-015684-q10sx1dm	28	39	elderly	elderly	JJ
cord-015684-q10sx1dm	28	40	(	(	-LRB-
cord-015684-q10sx1dm	28	41	antiparkinsonians	antiparkinsonian	NNS
cord-015684-q10sx1dm	28	42	,	,	,
cord-015684-q10sx1dm	28	43	anticonvulsants	anticonvulsant	NNS
cord-015684-q10sx1dm	28	44	,	,	,
cord-015684-q10sx1dm	28	45	vasoactive	vasoactive	JJ
cord-015684-q10sx1dm	28	46	compounds	compound	NNS
cord-015684-q10sx1dm	28	47	,	,	,
cord-015684-q10sx1dm	28	48	antiinfl	antiinfl	NNP
cord-015684-q10sx1dm	28	49	ammatory	ammatory	NNP
cord-015684-q10sx1dm	28	50	drugs	drug	NNS
cord-015684-q10sx1dm	28	51	,	,	,
cord-015684-q10sx1dm	28	52	etc	etc	FW
cord-015684-q10sx1dm	28	53	)	)	-RRB-
cord-015684-q10sx1dm	28	54	.	.	.
cord-015684-q10sx1dm	29	1	In	in	IN
cord-015684-q10sx1dm	29	2	addition	addition	NN
cord-015684-q10sx1dm	29	3	,	,	,
cord-015684-q10sx1dm	29	4	during	during	IN
cord-015684-q10sx1dm	29	5	the	the	DT
cord-015684-q10sx1dm	29	6	past	past	JJ
cord-015684-q10sx1dm	29	7	20	20	CD
cord-015684-q10sx1dm	29	8	years	year	NNS
cord-015684-q10sx1dm	29	9	more	more	JJR
cord-015684-q10sx1dm	29	10	than	than	IN
cord-015684-q10sx1dm	29	11	300	300	CD
cord-015684-q10sx1dm	29	12	drugs	drug	NNS
cord-015684-q10sx1dm	29	13	have	have	VBP
cord-015684-q10sx1dm	29	14	been	be	VBN
cord-015684-q10sx1dm	29	15	partially	partially	RB
cord-015684-q10sx1dm	29	16	or	or	CC
cord-015684-q10sx1dm	29	17	totally	totally	RB
cord-015684-q10sx1dm	29	18	developed	develop	VBN
cord-015684-q10sx1dm	29	19	for	for	IN
cord-015684-q10sx1dm	29	20	AD	ad	NN
cord-015684-q10sx1dm	29	21	,	,	,
cord-015684-q10sx1dm	29	22	with	with	IN
cord-015684-q10sx1dm	29	23	the	the	DT
cord-015684-q10sx1dm	29	24	subsequent	subsequent	JJ
cord-015684-q10sx1dm	29	25	costs	cost	NNS
cord-015684-q10sx1dm	29	26	for	for	IN
cord-015684-q10sx1dm	29	27	the	the	DT
cord-015684-q10sx1dm	29	28	pharmaceutical	pharmaceutical	NN
cord-015684-q10sx1dm	29	29	industry	industry	NN
cord-015684-q10sx1dm	29	30	,	,	,
cord-015684-q10sx1dm	29	31	and	and	CC
cord-015684-q10sx1dm	29	32	only	only	RB
cord-015684-q10sx1dm	29	33	5	5	CD
cord-015684-q10sx1dm	29	34	drugs	drug	NNS
cord-015684-q10sx1dm	29	35	with	with	IN
cord-015684-q10sx1dm	29	36	moderate	moderate	JJ
cord-015684-q10sx1dm	29	37	-	-	HYPH
cord-015684-q10sx1dm	29	38	to	to	IN
cord-015684-q10sx1dm	29	39	-	-	HYPH
cord-015684-q10sx1dm	29	40	poor	poor	JJ
cord-015684-q10sx1dm	29	41	effi	effi	NNP
cord-015684-q10sx1dm	29	42	cacy	cacy	NN
cord-015684-q10sx1dm	29	43	and	and	CC
cord-015684-q10sx1dm	29	44	questionable	questionable	JJ
cord-015684-q10sx1dm	29	45	cost	cost	NN
cord-015684-q10sx1dm	29	46	-	-	HYPH
cord-015684-q10sx1dm	29	47	effectiveness	effectiveness	NN
cord-015684-q10sx1dm	29	48	have	have	VBP
cord-015684-q10sx1dm	29	49	been	be	VBN
cord-015684-q10sx1dm	29	50	approved	approve	VBN
cord-015684-q10sx1dm	29	51	in	in	IN
cord-015684-q10sx1dm	29	52	developed	develop	VBN
cord-015684-q10sx1dm	29	53	countries	country	NNS
cord-015684-q10sx1dm	29	54	.	.	.
cord-015684-q10sx1dm	30	1	[	[	-LRB-
cord-015684-q10sx1dm	30	2	2	2	LS
cord-015684-q10sx1dm	30	3	]	]	-RRB-
cord-015684-q10sx1dm	30	4	[	[	-LRB-
cord-015684-q10sx1dm	30	5	3	3	CD
cord-015684-q10sx1dm	30	6	]	]	-RRB-
cord-015684-q10sx1dm	30	7	[	[	-LRB-
cord-015684-q10sx1dm	30	8	4	4	CD
cord-015684-q10sx1dm	30	9	]	]	-RRB-
cord-015684-q10sx1dm	31	1	The	the	DT
cord-015684-q10sx1dm	31	2	lack	lack	NN
cord-015684-q10sx1dm	31	3	of	of	IN
cord-015684-q10sx1dm	31	4	accurate	accurate	JJ
cord-015684-q10sx1dm	31	5	diagnostic	diagnostic	JJ
cord-015684-q10sx1dm	31	6	markers	marker	NNS
cord-015684-q10sx1dm	31	7	for	for	IN
cord-015684-q10sx1dm	31	8	early	early	JJ
cord-015684-q10sx1dm	31	9	prediction	prediction	NN
cord-015684-q10sx1dm	31	10	and	and	CC
cord-015684-q10sx1dm	31	11	an	an	DT
cord-015684-q10sx1dm	31	12	effective	effective	JJ
cord-015684-q10sx1dm	31	13	therapy	therapy	NN
cord-015684-q10sx1dm	31	14	of	of	IN
cord-015684-q10sx1dm	31	15	CNS	CNS	NNP
cord-015684-q10sx1dm	31	16	disorders	disorder	NNS
cord-015684-q10sx1dm	31	17	are	be	VBP
cord-015684-q10sx1dm	31	18	the	the	DT
cord-015684-q10sx1dm	31	19	two	two	CD
cord-015684-q10sx1dm	31	20	most	most	RBS
cord-015684-q10sx1dm	31	21	important	important	JJ
cord-015684-q10sx1dm	31	22	problems	problem	NNS
cord-015684-q10sx1dm	31	23	to	to	IN
cord-015684-q10sx1dm	31	24	effi	effi	NNP
cord-015684-q10sx1dm	31	25	ciently	ciently	RB
cord-015684-q10sx1dm	31	26	diagnose	diagnose	VB
cord-015684-q10sx1dm	31	27	and	and	CC
cord-015684-q10sx1dm	31	28	halt	halt	VB
cord-015684-q10sx1dm	31	29	disease	disease	NN
cord-015684-q10sx1dm	31	30	progression	progression	NN
cord-015684-q10sx1dm	31	31	.	.	.
cord-015684-q10sx1dm	32	1	The	the	DT
cord-015684-q10sx1dm	32	2	pharmacological	pharmacological	JJ
cord-015684-q10sx1dm	32	3	treatment	treatment	NN
cord-015684-q10sx1dm	32	4	of	of	IN
cord-015684-q10sx1dm	32	5	CNS	CNS	NNP
cord-015684-q10sx1dm	32	6	disorders	disorder	NNS
cord-015684-q10sx1dm	32	7	,	,	,
cord-015684-q10sx1dm	32	8	in	in	IN
cord-015684-q10sx1dm	32	9	general	general	JJ
cord-015684-q10sx1dm	32	10	,	,	,
cord-015684-q10sx1dm	32	11	accounts	account	VBZ
cord-015684-q10sx1dm	32	12	for	for	IN
cord-015684-q10sx1dm	32	13	10	10	CD
cord-015684-q10sx1dm	32	14	-	-	SYM
cord-015684-q10sx1dm	32	15	20	20	CD
cord-015684-q10sx1dm	32	16	%	%	NN
cord-015684-q10sx1dm	32	17	of	of	IN
cord-015684-q10sx1dm	32	18	direct	direct	JJ
cord-015684-q10sx1dm	32	19	costs	cost	NNS
cord-015684-q10sx1dm	32	20	,	,	,
cord-015684-q10sx1dm	32	21	and	and	CC
cord-015684-q10sx1dm	32	22	less	less	JJR
cord-015684-q10sx1dm	32	23	than	than	IN
cord-015684-q10sx1dm	32	24	30	30	CD
cord-015684-q10sx1dm	32	25	-	-	SYM
cord-015684-q10sx1dm	32	26	40	40	CD
cord-015684-q10sx1dm	32	27	%	%	NN
cord-015684-q10sx1dm	32	28	of	of	IN
cord-015684-q10sx1dm	32	29	the	the	DT
cord-015684-q10sx1dm	32	30	patients	patient	NNS
cord-015684-q10sx1dm	32	31	are	be	VBP
cord-015684-q10sx1dm	32	32	moderate	moderate	JJ
cord-015684-q10sx1dm	32	33	responders	responder	NNS
cord-015684-q10sx1dm	32	34	to	to	IN
cord-015684-q10sx1dm	32	35	conventional	conventional	JJ
cord-015684-q10sx1dm	32	36	drugs	drug	NNS
cord-015684-q10sx1dm	32	37	,	,	,
cord-015684-q10sx1dm	32	38	some	some	DT
cord-015684-q10sx1dm	32	39	of	of	IN
cord-015684-q10sx1dm	32	40	which	which	WDT
cord-015684-q10sx1dm	32	41	may	may	MD
cord-015684-q10sx1dm	32	42	cause	cause	VB
cord-015684-q10sx1dm	32	43	important	important	JJ
cord-015684-q10sx1dm	32	44	adverse	adverse	JJ
cord-015684-q10sx1dm	32	45	drugs	drug	NNS
cord-015684-q10sx1dm	32	46	reactions	reaction	NNS
cord-015684-q10sx1dm	32	47	(	(	-LRB-
cord-015684-q10sx1dm	32	48	ADRs	adr	NNS
cord-015684-q10sx1dm	32	49	)	)	-RRB-
cord-015684-q10sx1dm	32	50	.	.	.
cord-015684-q10sx1dm	33	1	In	in	IN
cord-015684-q10sx1dm	33	2	the	the	DT
cord-015684-q10sx1dm	33	3	case	case	NN
cord-015684-q10sx1dm	33	4	of	of	IN
cord-015684-q10sx1dm	33	5	dementia	dementia	NN
cord-015684-q10sx1dm	33	6	,	,	,
cord-015684-q10sx1dm	33	7	less	less	JJR
cord-015684-q10sx1dm	33	8	than	than	IN
cord-015684-q10sx1dm	33	9	20	20	CD
cord-015684-q10sx1dm	33	10	%	%	NN
cord-015684-q10sx1dm	33	11	of	of	IN
cord-015684-q10sx1dm	33	12	the	the	DT
cord-015684-q10sx1dm	33	13	patients	patient	NNS
cord-015684-q10sx1dm	33	14	can	can	MD
cord-015684-q10sx1dm	33	15	benefi	benefi	VB
cord-015684-q10sx1dm	33	16	t	t	NN
cord-015684-q10sx1dm	33	17	from	from	IN
cord-015684-q10sx1dm	33	18	current	current	JJ
cord-015684-q10sx1dm	33	19	drugs	drug	NNS
cord-015684-q10sx1dm	33	20	(	(	-LRB-
cord-015684-q10sx1dm	33	21	donepezil	donepezil	NNP
cord-015684-q10sx1dm	33	22	,	,	,
cord-015684-q10sx1dm	33	23	rivastigmine	rivastigmine	NNP
cord-015684-q10sx1dm	33	24	,	,	,
cord-015684-q10sx1dm	33	25	galantamine	galantamine	NNP
cord-015684-q10sx1dm	33	26	,	,	,
cord-015684-q10sx1dm	33	27	memantine	memantine	NNP
cord-015684-q10sx1dm	33	28	)	)	-RRB-
cord-015684-q10sx1dm	33	29	,	,	,
cord-015684-q10sx1dm	33	30	with	with	IN
cord-015684-q10sx1dm	33	31	doubtful	doubtful	JJ
cord-015684-q10sx1dm	33	32	cost	cost	NN
cord-015684-q10sx1dm	33	33	-	-	HYPH
cord-015684-q10sx1dm	33	34	effectiveness	effectiveness	NN
cord-015684-q10sx1dm	33	35	.	.	.
cord-015684-q10sx1dm	34	1	The	the	DT
cord-015684-q10sx1dm	34	2	pathogenic	pathogenic	JJ
cord-015684-q10sx1dm	34	3	mechanisms	mechanism	NNS
cord-015684-q10sx1dm	34	4	of	of	IN
cord-015684-q10sx1dm	34	5	most	most	JJS
cord-015684-q10sx1dm	34	6	CNS	cns	JJ
cord-015684-q10sx1dm	34	7	disorders	disorder	NNS
cord-015684-q10sx1dm	34	8	(	(	-LRB-
cord-015684-q10sx1dm	34	9	e.g.	e.g.	RB
cord-015684-q10sx1dm	34	10	,	,	,
cord-015684-q10sx1dm	34	11	psychosis	psychosis	NN
cord-015684-q10sx1dm	34	12	,	,	,
cord-015684-q10sx1dm	34	13	depression	depression	NN
cord-015684-q10sx1dm	34	14	,	,	,
cord-015684-q10sx1dm	34	15	anxiety	anxiety	NN
cord-015684-q10sx1dm	34	16	,	,	,
cord-015684-q10sx1dm	34	17	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	34	18	's	's	POS
cord-015684-q10sx1dm	34	19	disease	disease	NN
cord-015684-q10sx1dm	34	20	,	,	,
cord-015684-q10sx1dm	34	21	Parkinson	Parkinson	NNP
cord-015684-q10sx1dm	34	22	's	's	POS
cord-015684-q10sx1dm	34	23	disease	disease	NN
cord-015684-q10sx1dm	34	24	,	,	,
cord-015684-q10sx1dm	34	25	Huntington	Huntington	NNP
cord-015684-q10sx1dm	34	26	's	's	POS
cord-015684-q10sx1dm	34	27	disease	disease	NN
cord-015684-q10sx1dm	34	28	,	,	,
cord-015684-q10sx1dm	34	29	multiple	multiple	JJ
cord-015684-q10sx1dm	34	30	sclerosis	sclerosis	NN
cord-015684-q10sx1dm	34	31	,	,	,
cord-015684-q10sx1dm	34	32	etc	etc	FW
cord-015684-q10sx1dm	34	33	)	)	-RRB-
cord-015684-q10sx1dm	34	34	are	be	VBP
cord-015684-q10sx1dm	34	35	poorly	poorly	RB
cord-015684-q10sx1dm	34	36	understood	understand	VBN
cord-015684-q10sx1dm	34	37	.	.	.
cord-015684-q10sx1dm	35	1	This	this	DT
cord-015684-q10sx1dm	35	2	circumstance	circumstance	NN
cord-015684-q10sx1dm	35	3	makes	make	VBZ
cord-015684-q10sx1dm	35	4	it	-PRON-	PRP
cord-015684-q10sx1dm	35	5	diffi	diffi	JJ
cord-015684-q10sx1dm	35	6	cult	cult	NN
cord-015684-q10sx1dm	35	7	the	the	DT
cord-015684-q10sx1dm	35	8	implantation	implantation	NN
cord-015684-q10sx1dm	35	9	of	of	IN
cord-015684-q10sx1dm	35	10	a	a	DT
cord-015684-q10sx1dm	35	11	molecular	molecular	JJ
cord-015684-q10sx1dm	35	12	intervention	intervention	NN
cord-015684-q10sx1dm	35	13	to	to	TO
cord-015684-q10sx1dm	35	14	neutralize	neutralize	VB
cord-015684-q10sx1dm	35	15	causative	causative	JJ
cord-015684-q10sx1dm	35	16	factors	factor	NNS
cord-015684-q10sx1dm	35	17	.	.	.
cord-015684-q10sx1dm	36	1	In	in	IN
cord-015684-q10sx1dm	36	2	fact	fact	NN
cord-015684-q10sx1dm	36	3	,	,	,
cord-015684-q10sx1dm	36	4	more	more	JJR
cord-015684-q10sx1dm	36	5	than	than	IN
cord-015684-q10sx1dm	36	6	80	80	CD
cord-015684-q10sx1dm	36	7	%	%	NN
cord-015684-q10sx1dm	36	8	of	of	IN
cord-015684-q10sx1dm	36	9	the	the	DT
cord-015684-q10sx1dm	36	10	25,000	25,000	CD
cord-015684-q10sx1dm	36	11	genes	gene	NNS
cord-015684-q10sx1dm	36	12	integrating	integrate	VBG
cord-015684-q10sx1dm	36	13	the	the	DT
cord-015684-q10sx1dm	36	14	human	human	JJ
cord-015684-q10sx1dm	36	15	genome	genome	NN
cord-015684-q10sx1dm	36	16	are	be	VBP
cord-015684-q10sx1dm	36	17	expressed	express	VBN
cord-015684-q10sx1dm	36	18	in	in	IN
cord-015684-q10sx1dm	36	19	the	the	DT
cord-015684-q10sx1dm	36	20	CNS	CNS	NNP
cord-015684-q10sx1dm	36	21	at	at	IN
cord-015684-q10sx1dm	36	22	different	different	JJ
cord-015684-q10sx1dm	36	23	periods	period	NNS
cord-015684-q10sx1dm	36	24	of	of	IN
cord-015684-q10sx1dm	36	25	the	the	DT
cord-015684-q10sx1dm	36	26	life	life	NN
cord-015684-q10sx1dm	36	27	span	span	NN
cord-015684-q10sx1dm	36	28	,	,	,
cord-015684-q10sx1dm	36	29	and	and	CC
cord-015684-q10sx1dm	36	30	only	only	RB
cord-015684-q10sx1dm	36	31	a	a	DT
cord-015684-q10sx1dm	36	32	few	few	JJ
cord-015684-q10sx1dm	36	33	neurotransmitters	neurotransmitter	NNS
cord-015684-q10sx1dm	36	34	(	(	-LRB-
cord-015684-q10sx1dm	36	35	e.g.	e.g.	RB
cord-015684-q10sx1dm	36	36	,	,	,
cord-015684-q10sx1dm	36	37	noradrenaline	noradrenaline	NN
cord-015684-q10sx1dm	36	38	,	,	,
cord-015684-q10sx1dm	36	39	dopamine	dopamine	NN
cord-015684-q10sx1dm	36	40	,	,	,
cord-015684-q10sx1dm	36	41	acetylcholine	acetylcholine	NN
cord-015684-q10sx1dm	36	42	,	,	,
cord-015684-q10sx1dm	36	43	GABA	GABA	NNP
cord-015684-q10sx1dm	36	44	,	,	,
cord-015684-q10sx1dm	36	45	histamine	histamine	NN
cord-015684-q10sx1dm	36	46	,	,	,
cord-015684-q10sx1dm	36	47	and	and	CC
cord-015684-q10sx1dm	36	48	less	less	JJR
cord-015684-q10sx1dm	36	49	than	than	IN
cord-015684-q10sx1dm	36	50	ten	ten	CD
cord-015684-q10sx1dm	36	51	neuropeptides	neuropeptide	NNS
cord-015684-q10sx1dm	36	52	)	)	-RRB-
cord-015684-q10sx1dm	36	53	are	be	VBP
cord-015684-q10sx1dm	36	54	the	the	DT
cord-015684-q10sx1dm	36	55	actual	actual	JJ
cord-015684-q10sx1dm	36	56	targets	target	NNS
cord-015684-q10sx1dm	36	57	of	of	IN
cord-015684-q10sx1dm	36	58	conventional	conventional	JJ
cord-015684-q10sx1dm	36	59	psychopharmacology	psychopharmacology	NN
cord-015684-q10sx1dm	36	60	.	.	.
cord-015684-q10sx1dm	37	1	Common	common	JJ
cord-015684-q10sx1dm	37	2	features	feature	NNS
cord-015684-q10sx1dm	37	3	in	in	IN
cord-015684-q10sx1dm	37	4	CNS	CNS	NNP
cord-015684-q10sx1dm	37	5	disorders	disorder	NNS
cord-015684-q10sx1dm	37	6	include	include	VBP
cord-015684-q10sx1dm	37	7	the	the	DT
cord-015684-q10sx1dm	37	8	following	follow	VBG
cord-015684-q10sx1dm	37	9	:	:	:
cord-015684-q10sx1dm	37	10	(	(	-LRB-
cord-015684-q10sx1dm	37	11	a	a	LS
cord-015684-q10sx1dm	37	12	)	)	-RRB-
cord-015684-q10sx1dm	37	13	polygenic/	polygenic/	JJ
cord-015684-q10sx1dm	37	14	complex	complex	JJ
cord-015684-q10sx1dm	37	15	disorders	disorder	NNS
cord-015684-q10sx1dm	37	16	in	in	IN
cord-015684-q10sx1dm	37	17	which	which	WDT
cord-015684-q10sx1dm	37	18	genomic	genomic	JJ
cord-015684-q10sx1dm	37	19	and	and	CC
cord-015684-q10sx1dm	37	20	environmental	environmental	JJ
cord-015684-q10sx1dm	37	21	factors	factor	NNS
cord-015684-q10sx1dm	37	22	are	be	VBP
cord-015684-q10sx1dm	37	23	involved	involve	VBN
cord-015684-q10sx1dm	37	24	;	;	:
cord-015684-q10sx1dm	37	25	(	(	-LRB-
cord-015684-q10sx1dm	37	26	b	b	NN
cord-015684-q10sx1dm	37	27	)	)	-RRB-
cord-015684-q10sx1dm	37	28	deterioration	deterioration	NN
cord-015684-q10sx1dm	37	29	of	of	IN
cord-015684-q10sx1dm	37	30	higher	high	JJR
cord-015684-q10sx1dm	37	31	activities	activity	NNS
cord-015684-q10sx1dm	37	32	of	of	IN
cord-015684-q10sx1dm	37	33	the	the	DT
cord-015684-q10sx1dm	37	34	CNS	CNS	NNP
cord-015684-q10sx1dm	37	35	;	;	:
cord-015684-q10sx1dm	37	36	(	(	-LRB-
cord-015684-q10sx1dm	37	37	c	c	NN
cord-015684-q10sx1dm	37	38	)	)	-RRB-
cord-015684-q10sx1dm	37	39	multifactorial	multifactorial	JJ
cord-015684-q10sx1dm	37	40	dysfunctions	dysfunction	NNS
cord-015684-q10sx1dm	37	41	in	in	IN
cord-015684-q10sx1dm	37	42	several	several	JJ
cord-015684-q10sx1dm	37	43	brain	brain	NN
cord-015684-q10sx1dm	37	44	circuits	circuit	NNS
cord-015684-q10sx1dm	37	45	;	;	:
cord-015684-q10sx1dm	37	46	and	and	CC
cord-015684-q10sx1dm	37	47	(	(	-LRB-
cord-015684-q10sx1dm	37	48	d	d	LS
cord-015684-q10sx1dm	37	49	)	)	-RRB-
cord-015684-q10sx1dm	37	50	accumulation	accumulation	NN
cord-015684-q10sx1dm	37	51	of	of	IN
cord-015684-q10sx1dm	37	52	toxic	toxic	JJ
cord-015684-q10sx1dm	37	53	proteins	protein	NNS
cord-015684-q10sx1dm	37	54	in	in	IN
cord-015684-q10sx1dm	37	55	the	the	DT
cord-015684-q10sx1dm	37	56	nervous	nervous	JJ
cord-015684-q10sx1dm	37	57	tissue	tissue	NN
cord-015684-q10sx1dm	37	58	in	in	IN
cord-015684-q10sx1dm	37	59	cases	case	NNS
cord-015684-q10sx1dm	37	60	of	of	IN
cord-015684-q10sx1dm	37	61	neurodegeneration	neurodegeneration	NN
cord-015684-q10sx1dm	37	62	.	.	.
cord-015684-q10sx1dm	38	1	For	for	IN
cord-015684-q10sx1dm	38	2	instance	instance	NN
cord-015684-q10sx1dm	38	3	,	,	,
cord-015684-q10sx1dm	38	4	the	the	DT
cord-015684-q10sx1dm	38	5	neuropathological	neuropathological	JJ
cord-015684-q10sx1dm	38	6	hallmark	hallmark	NN
cord-015684-q10sx1dm	38	7	of	of	IN
cord-015684-q10sx1dm	38	8	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	38	9	's	's	POS
cord-015684-q10sx1dm	38	10	disease	disease	NN
cord-015684-q10sx1dm	38	11	(	(	-LRB-
cord-015684-q10sx1dm	38	12	AD	ad	NN
cord-015684-q10sx1dm	38	13	)	)	-RRB-
cord-015684-q10sx1dm	38	14	(	(	-LRB-
cord-015684-q10sx1dm	38	15	amyloid	amyloid	NN
cord-015684-q10sx1dm	38	16	deposition	deposition	NN
cord-015684-q10sx1dm	38	17	in	in	IN
cord-015684-q10sx1dm	38	18	senile	senile	JJ
cord-015684-q10sx1dm	38	19	plaques	plaque	NNS
cord-015684-q10sx1dm	38	20	,	,	,
cord-015684-q10sx1dm	38	21	neurofi	neurofi	NNP
cord-015684-q10sx1dm	38	22	brillary	brillary	NNP
cord-015684-q10sx1dm	38	23	tangle	tangle	NNP
cord-015684-q10sx1dm	38	24	formation	formation	NN
cord-015684-q10sx1dm	38	25	,	,	,
cord-015684-q10sx1dm	38	26	and	and	CC
cord-015684-q10sx1dm	38	27	neuronal	neuronal	JJ
cord-015684-q10sx1dm	38	28	loss	loss	NN
cord-015684-q10sx1dm	38	29	)	)	-RRB-
cord-015684-q10sx1dm	38	30	is	be	VBZ
cord-015684-q10sx1dm	38	31	but	but	CC
cord-015684-q10sx1dm	38	32	the	the	DT
cord-015684-q10sx1dm	38	33	phenotypic	phenotypic	JJ
cord-015684-q10sx1dm	38	34	expression	expression	NN
cord-015684-q10sx1dm	38	35	of	of	IN
cord-015684-q10sx1dm	38	36	a	a	DT
cord-015684-q10sx1dm	38	37	pathogenic	pathogenic	JJ
cord-015684-q10sx1dm	38	38	process	process	NN
cord-015684-q10sx1dm	38	39	in	in	IN
cord-015684-q10sx1dm	38	40	which	which	WDT
cord-015684-q10sx1dm	38	41	more	more	JJR
cord-015684-q10sx1dm	38	42	than	than	IN
cord-015684-q10sx1dm	38	43	200	200	CD
cord-015684-q10sx1dm	38	44	genes	gene	NNS
cord-015684-q10sx1dm	38	45	and	and	CC
cord-015684-q10sx1dm	38	46	their	-PRON-	PRP$
cord-015684-q10sx1dm	38	47	products	product	NNS
cord-015684-q10sx1dm	38	48	are	be	VBP
cord-015684-q10sx1dm	38	49	potentially	potentially	RB
cord-015684-q10sx1dm	38	50	involved	involve	VBN
cord-015684-q10sx1dm	38	51	.	.	.
cord-015684-q10sx1dm	39	1	Drug	drug	NN
cord-015684-q10sx1dm	39	2	metabolism	metabolism	NN
cord-015684-q10sx1dm	39	3	,	,	,
cord-015684-q10sx1dm	39	4	and	and	CC
cord-015684-q10sx1dm	39	5	the	the	DT
cord-015684-q10sx1dm	39	6	mechanisms	mechanism	NNS
cord-015684-q10sx1dm	39	7	underlying	underlie	VBG
cord-015684-q10sx1dm	39	8	drug	drug	NN
cord-015684-q10sx1dm	39	9	effi	effi	NNP
cord-015684-q10sx1dm	39	10	cacy	cacy	NNP
cord-015684-q10sx1dm	39	11	and	and	CC
cord-015684-q10sx1dm	39	12	safety	safety	NN
cord-015684-q10sx1dm	39	13	,	,	,
cord-015684-q10sx1dm	39	14	are	be	VBP
cord-015684-q10sx1dm	39	15	also	also	RB
cord-015684-q10sx1dm	39	16	genetically	genetically	RB
cord-015684-q10sx1dm	39	17	regulated	regulate	VBN
cord-015684-q10sx1dm	39	18	complex	complex	JJ
cord-015684-q10sx1dm	39	19	traits	trait	NNS
cord-015684-q10sx1dm	39	20	in	in	IN
cord-015684-q10sx1dm	39	21	which	which	WDT
cord-015684-q10sx1dm	39	22	hundreds	hundred	NNS
cord-015684-q10sx1dm	39	23	of	of	IN
cord-015684-q10sx1dm	39	24	genes	gene	NNS
cord-015684-q10sx1dm	39	25	cooperatively	cooperatively	RB
cord-015684-q10sx1dm	39	26	participate	participate	VBP
cord-015684-q10sx1dm	39	27	.	.	.
cord-015684-q10sx1dm	40	1	Structural	structural	JJ
cord-015684-q10sx1dm	40	2	and	and	CC
cord-015684-q10sx1dm	40	3	functional	functional	JJ
cord-015684-q10sx1dm	40	4	genomics	genomic	NNS
cord-015684-q10sx1dm	40	5	studies	study	NNS
cord-015684-q10sx1dm	40	6	demonstrate	demonstrate	VBP
cord-015684-q10sx1dm	40	7	that	that	IN
cord-015684-q10sx1dm	40	8	genomic	genomic	JJ
cord-015684-q10sx1dm	40	9	factors	factor	NNS
cord-015684-q10sx1dm	40	10	,	,	,
cord-015684-q10sx1dm	40	11	probably	probably	RB
cord-015684-q10sx1dm	40	12	induced	induce	VBN
cord-015684-q10sx1dm	40	13	by	by	IN
cord-015684-q10sx1dm	40	14	environmental	environmental	JJ
cord-015684-q10sx1dm	40	15	factors	factor	NNS
cord-015684-q10sx1dm	40	16	,	,	,
cord-015684-q10sx1dm	40	17	cerebrovascular	cerebrovascular	JJ
cord-015684-q10sx1dm	40	18	dysfunction	dysfunction	NN
cord-015684-q10sx1dm	40	19	,	,	,
cord-015684-q10sx1dm	40	20	and	and	CC
cord-015684-q10sx1dm	40	21	epigenetic	epigenetic	JJ
cord-015684-q10sx1dm	40	22	phenomena	phenomenon	NNS
cord-015684-q10sx1dm	40	23	,	,	,
cord-015684-q10sx1dm	40	24	might	may	MD
cord-015684-q10sx1dm	40	25	be	be	VB
cord-015684-q10sx1dm	40	26	responsible	responsible	JJ
cord-015684-q10sx1dm	40	27	for	for	IN
cord-015684-q10sx1dm	40	28	pathogenic	pathogenic	JJ
cord-015684-q10sx1dm	40	29	events	event	NNS
cord-015684-q10sx1dm	40	30	leading	lead	VBG
cord-015684-q10sx1dm	40	31	to	to	IN
cord-015684-q10sx1dm	40	32	premature	premature	JJ
cord-015684-q10sx1dm	40	33	neuronal	neuronal	JJ
cord-015684-q10sx1dm	40	34	dysfunction	dysfunction	NN
cord-015684-q10sx1dm	40	35	and/or	and/or	CC
cord-015684-q10sx1dm	40	36	death	death	NN
cord-015684-q10sx1dm	40	37	.	.	.
cord-015684-q10sx1dm	41	1	Pharmacogenetic	pharmacogenetic	JJ
cord-015684-q10sx1dm	41	2	and	and	CC
cord-015684-q10sx1dm	41	3	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	41	4	factors	factor	NNS
cord-015684-q10sx1dm	41	5	may	may	MD
cord-015684-q10sx1dm	41	6	account	account	VB
cord-015684-q10sx1dm	41	7	for	for	IN
cord-015684-q10sx1dm	41	8	60	60	CD
cord-015684-q10sx1dm	41	9	-	-	SYM
cord-015684-q10sx1dm	41	10	90	90	CD
cord-015684-q10sx1dm	41	11	%	%	NN
cord-015684-q10sx1dm	41	12	of	of	IN
cord-015684-q10sx1dm	41	13	drug	drug	NN
cord-015684-q10sx1dm	41	14	variability	variability	NN
cord-015684-q10sx1dm	41	15	in	in	IN
cord-015684-q10sx1dm	41	16	drug	drug	NN
cord-015684-q10sx1dm	41	17	disposition	disposition	NN
cord-015684-q10sx1dm	41	18	and	and	CC
cord-015684-q10sx1dm	41	19	pharmacodynamics	pharmacodynamic	NNS
cord-015684-q10sx1dm	41	20	.	.	.
cord-015684-q10sx1dm	42	1	About	about	RB
cord-015684-q10sx1dm	42	2	10	10	CD
cord-015684-q10sx1dm	42	3	-	-	SYM
cord-015684-q10sx1dm	42	4	20	20	CD
cord-015684-q10sx1dm	42	5	%	%	NN
cord-015684-q10sx1dm	42	6	of	of	IN
cord-015684-q10sx1dm	42	7	Caucasians	Caucasians	NNPS
cord-015684-q10sx1dm	42	8	are	be	VBP
cord-015684-q10sx1dm	42	9	carriers	carrier	NNS
cord-015684-q10sx1dm	42	10	of	of	IN
cord-015684-q10sx1dm	42	11	defective	defective	JJ
cord-015684-q10sx1dm	42	12	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	42	13	polymorphic	polymorphic	JJ
cord-015684-q10sx1dm	42	14	variants	variant	NNS
cord-015684-q10sx1dm	42	15	that	that	WDT
cord-015684-q10sx1dm	42	16	alter	alter	VBP
cord-015684-q10sx1dm	42	17	the	the	DT
cord-015684-q10sx1dm	42	18	metabolism	metabolism	NN
cord-015684-q10sx1dm	42	19	of	of	IN
cord-015684-q10sx1dm	42	20	many	many	JJ
cord-015684-q10sx1dm	42	21	psychotropic	psychotropic	JJ
cord-015684-q10sx1dm	42	22	agents	agent	NNS
cord-015684-q10sx1dm	42	23	.	.	.
cord-015684-q10sx1dm	43	1	The	the	DT
cord-015684-q10sx1dm	43	2	incorporation	incorporation	NN
cord-015684-q10sx1dm	43	3	of	of	IN
cord-015684-q10sx1dm	43	4	pharmacogenetic	pharmacogenetic	JJ
cord-015684-q10sx1dm	43	5	/	/	SYM
cord-015684-q10sx1dm	43	6	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	43	7	protocols	protocol	NNS
cord-015684-q10sx1dm	43	8	to	to	IN
cord-015684-q10sx1dm	43	9	CNS	CNS	NNP
cord-015684-q10sx1dm	43	10	research	research	NN
cord-015684-q10sx1dm	43	11	and	and	CC
cord-015684-q10sx1dm	43	12	clinical	clinical	JJ
cord-015684-q10sx1dm	43	13	practice	practice	NN
cord-015684-q10sx1dm	43	14	can	can	MD
cord-015684-q10sx1dm	43	15	foster	foster	VB
cord-015684-q10sx1dm	43	16	therapeutics	therapeutics	NN
cord-015684-q10sx1dm	43	17	optimization	optimization	NN
cord-015684-q10sx1dm	43	18	by	by	IN
cord-015684-q10sx1dm	43	19	helping	help	VBG
cord-015684-q10sx1dm	43	20	to	to	TO
cord-015684-q10sx1dm	43	21	develop	develop	VB
cord-015684-q10sx1dm	43	22	cost	cost	NN
cord-015684-q10sx1dm	43	23	-	-	HYPH
cord-015684-q10sx1dm	43	24	effective	effective	JJ
cord-015684-q10sx1dm	43	25	pharmaceuticals	pharmaceutical	NNS
cord-015684-q10sx1dm	43	26	and	and	CC
cord-015684-q10sx1dm	43	27	improving	improve	VBG
cord-015684-q10sx1dm	43	28	drug	drug	NN
cord-015684-q10sx1dm	43	29	effi	effi	NNP
cord-015684-q10sx1dm	43	30	cacy	cacy	NNP
cord-015684-q10sx1dm	43	31	and	and	CC
cord-015684-q10sx1dm	43	32	safety	safety	NN
cord-015684-q10sx1dm	43	33	.	.	.
cord-015684-q10sx1dm	44	1	[	[	-LRB-
cord-015684-q10sx1dm	44	2	5	5	CD
cord-015684-q10sx1dm	44	3	]	]	-RRB-
cord-015684-q10sx1dm	44	4	[	[	-LRB-
cord-015684-q10sx1dm	44	5	6	6	CD
cord-015684-q10sx1dm	44	6	]	]	-RRB-
cord-015684-q10sx1dm	44	7	[	[	-LRB-
cord-015684-q10sx1dm	44	8	7	7	CD
cord-015684-q10sx1dm	44	9	]	]	-RRB-
cord-015684-q10sx1dm	44	10	 	 	_SP
cord-015684-q10sx1dm	45	1	Extensive	extensive	JJ
cord-015684-q10sx1dm	45	2	molecular	molecular	JJ
cord-015684-q10sx1dm	45	3	genetics	genetics	NN
cord-015684-q10sx1dm	45	4	studies	study	NNS
cord-015684-q10sx1dm	45	5	carried	carry	VBN
cord-015684-q10sx1dm	45	6	out	out	RP
cord-015684-q10sx1dm	45	7	in	in	IN
cord-015684-q10sx1dm	45	8	the	the	DT
cord-015684-q10sx1dm	45	9	past	past	JJ
cord-015684-q10sx1dm	45	10	2	2	CD
cord-015684-q10sx1dm	45	11	decades	decade	NNS
cord-015684-q10sx1dm	45	12	have	have	VBP
cord-015684-q10sx1dm	45	13	demonstrated	demonstrate	VBN
cord-015684-q10sx1dm	45	14	that	that	IN
cord-015684-q10sx1dm	45	15	most	most	JJS
cord-015684-q10sx1dm	45	16	CNS	cns	JJ
cord-015684-q10sx1dm	45	17	disorders	disorder	NNS
cord-015684-q10sx1dm	45	18	are	be	VBP
cord-015684-q10sx1dm	45	19	multifactorial	multifactorial	JJ
cord-015684-q10sx1dm	45	20	,	,	,
cord-015684-q10sx1dm	45	21	polygenic	polygenic	JJ
cord-015684-q10sx1dm	45	22	/	/	SYM
cord-015684-q10sx1dm	45	23	complex	complex	JJ
cord-015684-q10sx1dm	45	24	disorders	disorder	NNS
cord-015684-q10sx1dm	45	25	in	in	IN
cord-015684-q10sx1dm	45	26	which	which	WDT
cord-015684-q10sx1dm	45	27	hundreds	hundred	NNS
cord-015684-q10sx1dm	45	28	of	of	IN
cord-015684-q10sx1dm	45	29	genes	gene	NNS
cord-015684-q10sx1dm	45	30	distributed	distribute	VBN
cord-015684-q10sx1dm	45	31	across	across	IN
cord-015684-q10sx1dm	45	32	the	the	DT
cord-015684-q10sx1dm	45	33	human	human	JJ
cord-015684-q10sx1dm	45	34	genome	genome	NN
cord-015684-q10sx1dm	45	35	might	may	MD
cord-015684-q10sx1dm	45	36	be	be	VB
cord-015684-q10sx1dm	45	37	involved	involve	VBN
cord-015684-q10sx1dm	45	38	(	(	-LRB-
cord-015684-q10sx1dm	45	39	Tables	table	NNS
cord-015684-q10sx1dm	45	40	40.1	40.1	CD
cord-015684-q10sx1dm	45	41	-	-	SYM
cord-015684-q10sx1dm	45	42	40	40	CD
cord-015684-q10sx1dm	45	43	.	.	.
cord-015684-q10sx1dm	45	44	3	3	CD
cord-015684-q10sx1dm	45	45	)	)	-RRB-
cord-015684-q10sx1dm	45	46	.	.	.
cord-015684-q10sx1dm	46	1	8	8	CD
cord-015684-q10sx1dm	46	2	,	,	,
cord-015684-q10sx1dm	46	3	9	9	CD
cord-015684-q10sx1dm	47	1	For	for	IN
cord-015684-q10sx1dm	47	2	example	example	NN
cord-015684-q10sx1dm	47	3	,	,	,
cord-015684-q10sx1dm	47	4	255	255	CD
cord-015684-q10sx1dm	47	5	genes	gene	NNS
cord-015684-q10sx1dm	47	6	have	have	VBP
cord-015684-q10sx1dm	47	7	been	be	VBN
cord-015684-q10sx1dm	47	8	associated	associate	VBN
cord-015684-q10sx1dm	47	9	with	with	IN
cord-015684-q10sx1dm	47	10	dementia	dementia	NN
cord-015684-q10sx1dm	47	11	(	(	-LRB-
cord-015684-q10sx1dm	47	12	Table	table	NN
cord-015684-q10sx1dm	47	13	40	40	CD
cord-015684-q10sx1dm	47	14	.1	.1	CD
cord-015684-q10sx1dm	47	15	)	)	-RRB-
cord-015684-q10sx1dm	47	16	,	,	,
cord-015684-q10sx1dm	47	17	205	205	CD
cord-015684-q10sx1dm	47	18	with	with	IN
cord-015684-q10sx1dm	47	19	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	47	20	(	(	-LRB-
cord-015684-q10sx1dm	47	21	Table	Table	NNP
cord-015684-q10sx1dm	47	22	 	 	_SP
cord-015684-q10sx1dm	47	23	40	40	CD
cord-015684-q10sx1dm	47	24	.	.	.
cord-015684-q10sx1dm	47	25	2	2	LS
cord-015684-q10sx1dm	47	26	)	)	-RRB-
cord-015684-q10sx1dm	47	27	,	,	,
cord-015684-q10sx1dm	47	28	106	106	CD
cord-015684-q10sx1dm	47	29	with	with	IN
cord-015684-q10sx1dm	47	30	depression	depression	NN
cord-015684-q10sx1dm	47	31	(	(	-LRB-
cord-015684-q10sx1dm	47	32	Table	table	NN
cord-015684-q10sx1dm	47	33	40	40	CD
cord-015684-q10sx1dm	47	34	.	.	.
cord-015684-q10sx1dm	47	35	3	3	LS
cord-015684-q10sx1dm	47	36	)	)	-RRB-
cord-015684-q10sx1dm	47	37	,	,	,
cord-015684-q10sx1dm	47	38	107	107	CD
cord-015684-q10sx1dm	47	39	with	with	IN
cord-015684-q10sx1dm	47	40	anxiety	anxiety	NN
cord-015684-q10sx1dm	47	41	,	,	,
cord-015684-q10sx1dm	47	42	103	103	CD
cord-015684-q10sx1dm	47	43	with	with	IN
cord-015684-q10sx1dm	47	44	stroke	stroke	NN
cord-015684-q10sx1dm	47	45	,	,	,
cord-015684-q10sx1dm	47	46	385	385	CD
cord-015684-q10sx1dm	47	47	with	with	IN
cord-015684-q10sx1dm	47	48	different	different	JJ
cord-015684-q10sx1dm	47	49	types	type	NNS
cord-015684-q10sx1dm	47	50	of	of	IN
cord-015684-q10sx1dm	47	51	ataxia	ataxia	NN
cord-015684-q10sx1dm	47	52	,	,	,
cord-015684-q10sx1dm	47	53	155	155	CD
cord-015684-q10sx1dm	47	54	with	with	IN
cord-015684-q10sx1dm	47	55	epilepsiy	epilepsiy	NNP
cord-015684-q10sx1dm	47	56	,	,	,
cord-015684-q10sx1dm	47	57	83	83	CD
cord-015684-q10sx1dm	47	58	with	with	IN
cord-015684-q10sx1dm	47	59	meningioma	meningioma	NN
cord-015684-q10sx1dm	47	60	,	,	,
cord-015684-q10sx1dm	47	61	105	105	CD
cord-015684-q10sx1dm	47	62	with	with	IN
cord-015684-q10sx1dm	47	63	glioblastoma	glioblastoma	NN
cord-015684-q10sx1dm	47	64	,	,	,
cord-015684-q10sx1dm	47	65	27	27	CD
cord-015684-q10sx1dm	47	66	with	with	IN
cord-015684-q10sx1dm	47	67	astrocytoma	astrocytoma	NN
cord-015684-q10sx1dm	47	68	,	,	,
cord-015684-q10sx1dm	47	69	73	73	CD
cord-015684-q10sx1dm	47	70	with	with	IN
cord-015684-q10sx1dm	47	71	Parkinson	Parkinson	NNP
cord-015684-q10sx1dm	47	72	's	's	POS
cord-015684-q10sx1dm	47	73	disease	disease	NN
cord-015684-q10sx1dm	47	74	,	,	,
cord-015684-q10sx1dm	47	75	and	and	CC
cord-015684-q10sx1dm	47	76	more	more	JJR
cord-015684-q10sx1dm	47	77	than	than	IN
cord-015684-q10sx1dm	47	78	30	30	CD
cord-015684-q10sx1dm	47	79	genes	gene	NNS
cord-015684-q10sx1dm	47	80	with	with	IN
cord-015684-q10sx1dm	47	81	cerebrovascular	cerebrovascular	JJ
cord-015684-q10sx1dm	47	82	disorders	disorder	NNS
cord-015684-q10sx1dm	47	83	.	.	.
cord-015684-q10sx1dm	48	1	8	8	CD
cord-015684-q10sx1dm	48	2	,	,	,
cord-015684-q10sx1dm	48	3	10	10	CD
cord-015684-q10sx1dm	48	4	Many	many	JJ
cord-015684-q10sx1dm	48	5	of	of	IN
cord-015684-q10sx1dm	48	6	these	these	DT
cord-015684-q10sx1dm	48	7	genetic	genetic	JJ
cord-015684-q10sx1dm	48	8	associations	association	NNS
cord-015684-q10sx1dm	48	9	could	could	MD
cord-015684-q10sx1dm	48	10	not	not	RB
cord-015684-q10sx1dm	48	11	be	be	VB
cord-015684-q10sx1dm	48	12	replicated	replicate	VBN
cord-015684-q10sx1dm	48	13	in	in	IN
cord-015684-q10sx1dm	48	14	different	different	JJ
cord-015684-q10sx1dm	48	15	settings	setting	NNS
cord-015684-q10sx1dm	48	16	and	and	CC
cord-015684-q10sx1dm	48	17	different	different	JJ
cord-015684-q10sx1dm	48	18	populations	population	NNS
cord-015684-q10sx1dm	48	19	due	due	JJ
cord-015684-q10sx1dm	48	20	to	to	IN
cord-015684-q10sx1dm	48	21	many	many	JJ
cord-015684-q10sx1dm	48	22	complex	complex	JJ
cord-015684-q10sx1dm	48	23	(	(	-LRB-
cord-015684-q10sx1dm	48	24	methodological	methodological	JJ
cord-015684-q10sx1dm	48	25	,	,	,
cord-015684-q10sx1dm	48	26	technological	technological	JJ
cord-015684-q10sx1dm	48	27	)	)	-RRB-
cord-015684-q10sx1dm	48	28	factors	factor	NNS
cord-015684-q10sx1dm	48	29	.	.	.
cord-015684-q10sx1dm	49	1	8	8	CD
cord-015684-q10sx1dm	49	2	,	,	,
cord-015684-q10sx1dm	49	3	11	11	CD
cord-015684-q10sx1dm	49	4	,	,	,
cord-015684-q10sx1dm	49	5	12	12	CD
cord-015684-q10sx1dm	50	1	Furthermore	furthermore	RB
cord-015684-q10sx1dm	50	2	,	,	,
cord-015684-q10sx1dm	50	3	the	the	DT
cord-015684-q10sx1dm	50	4	same	same	JJ
cord-015684-q10sx1dm	50	5	genomic	genomic	JJ
cord-015684-q10sx1dm	50	6	defect	defect	NN
cord-015684-q10sx1dm	50	7	can	can	MD
cord-015684-q10sx1dm	50	8	give	give	VB
cord-015684-q10sx1dm	50	9	rise	rise	NN
cord-015684-q10sx1dm	50	10	to	to	IN
cord-015684-q10sx1dm	50	11	apparent	apparent	JJ
cord-015684-q10sx1dm	50	12	diverse	diverse	JJ
cord-015684-q10sx1dm	50	13	phenotypes	phenotype	NNS
cord-015684-q10sx1dm	50	14	,	,	,
cord-015684-q10sx1dm	50	15	and	and	CC
cord-015684-q10sx1dm	50	16	different	different	JJ
cord-015684-q10sx1dm	50	17	genomic	genomic	JJ
cord-015684-q10sx1dm	50	18	defects	defect	NNS
cord-015684-q10sx1dm	50	19	can	can	MD
cord-015684-q10sx1dm	50	20	converge	converge	VB
cord-015684-q10sx1dm	50	21	in	in	IN
cord-015684-q10sx1dm	50	22	an	an	DT
cord-015684-q10sx1dm	50	23	apparently	apparently	RB
cord-015684-q10sx1dm	50	24	common	common	JJ
cord-015684-q10sx1dm	50	25	phenotype	phenotype	NN
cord-015684-q10sx1dm	50	26	,	,	,
cord-015684-q10sx1dm	50	27	this	this	DT
cord-015684-q10sx1dm	50	28	increasing	increase	VBG
cord-015684-q10sx1dm	50	29	the	the	DT
cord-015684-q10sx1dm	50	30	complexity	complexity	NN
cord-015684-q10sx1dm	50	31	of	of	IN
cord-015684-q10sx1dm	50	32	genomic	genomic	JJ
cord-015684-q10sx1dm	50	33	studies	study	NNS
cord-015684-q10sx1dm	50	34	(	(	-LRB-
cord-015684-q10sx1dm	50	35	e.g.	e.g.	RB
cord-015684-q10sx1dm	50	36	,	,	,
cord-015684-q10sx1dm	50	37	patient	patient	NN
cord-015684-q10sx1dm	50	38	recruitment	recruitment	NN
cord-015684-q10sx1dm	50	39	,	,	,
cord-015684-q10sx1dm	50	40	pure	pure	JJ
cord-015684-q10sx1dm	50	41	controls	control	NNS
cord-015684-q10sx1dm	50	42	,	,	,
cord-015684-q10sx1dm	50	43	concomitant	concomitant	JJ
cord-015684-q10sx1dm	50	44	pathology	pathology	NN
cord-015684-q10sx1dm	50	45	,	,	,
cord-015684-q10sx1dm	50	46	epigenetic	epigenetic	JJ
cord-015684-q10sx1dm	50	47	factors	factor	NNS
cord-015684-q10sx1dm	50	48	,	,	,
cord-015684-q10sx1dm	50	49	environmental	environmental	JJ
cord-015684-q10sx1dm	50	50	factors	factor	NNS
cord-015684-q10sx1dm	50	51	)	)	-RRB-
cord-015684-q10sx1dm	50	52	.	.	.
cord-015684-q10sx1dm	51	1	Several	several	JJ
cord-015684-q10sx1dm	51	2	candidate	candidate	NN
cord-015684-q10sx1dm	51	3	genes	gene	NNS
cord-015684-q10sx1dm	51	4	for	for	IN
cord-015684-q10sx1dm	51	5	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	51	6	may	may	MD
cord-015684-q10sx1dm	51	7	also	also	RB
cord-015684-q10sx1dm	51	8	be	be	VB
cord-015684-q10sx1dm	51	9	associated	associate	VBN
cord-015684-q10sx1dm	51	10	with	with	IN
cord-015684-q10sx1dm	51	11	bipolar	bipolar	JJ
cord-015684-q10sx1dm	51	12	disorder	disorder	NN
cord-015684-q10sx1dm	51	13	,	,	,
cord-015684-q10sx1dm	51	14	including	include	VBG
cord-015684-q10sx1dm	51	15	G72	G72	NNP
cord-015684-q10sx1dm	51	16	,	,	,
cord-015684-q10sx1dm	51	17	DISC1	DISC1	NNS
cord-015684-q10sx1dm	51	18	,	,	,
cord-015684-q10sx1dm	51	19	NRG1	NRG1	NNP
cord-015684-q10sx1dm	51	20	,	,	,
cord-015684-q10sx1dm	51	21	RGS4	rgs4	RB
cord-015684-q10sx1dm	51	22	,	,	,
cord-015684-q10sx1dm	51	23	NCAM1	NCAM1	NNP
cord-015684-q10sx1dm	51	24	,	,	,
cord-015684-q10sx1dm	51	25	DAO	DAO	NNP
cord-015684-q10sx1dm	51	26	,	,	,
cord-015684-q10sx1dm	51	27	GRM3	GRM3	NNP
cord-015684-q10sx1dm	51	28	,	,	,
cord-015684-q10sx1dm	51	29	GRM4	GRM4	NNP
cord-015684-q10sx1dm	51	30	,	,	,
cord-015684-q10sx1dm	51	31	GRIN2B	GRIN2B	NNP
cord-015684-q10sx1dm	51	32	,	,	,
cord-015684-q10sx1dm	51	33	MLC1	MLC1	NNP
cord-015684-q10sx1dm	51	34	,	,	,
cord-015684-q10sx1dm	51	35	SYNGR1	syngr1	NN
cord-015684-q10sx1dm	51	36	,	,	,
cord-015684-q10sx1dm	51	37	and	and	CC
cord-015684-q10sx1dm	51	38	SLC12A6	slc12a6	NN
cord-015684-q10sx1dm	51	39	.	.	.
cord-015684-q10sx1dm	52	1	Genes	gene	NNS
cord-015684-q10sx1dm	52	2	associated	associate	VBN
cord-015684-q10sx1dm	52	3	with	with	IN
cord-015684-q10sx1dm	52	4	bipolar	bipolar	JJ
cord-015684-q10sx1dm	52	5	disorder	disorder	NN
cord-015684-q10sx1dm	52	6	include	include	VBP
cord-015684-q10sx1dm	52	7	TRPM2	TRPM2	VBN
cord-015684-q10sx1dm	52	8	(	(	-LRB-
cord-015684-q10sx1dm	52	9	21q22.3	21q22.3	NNP
cord-015684-q10sx1dm	52	10	)	)	-RRB-
cord-015684-q10sx1dm	52	11	,	,	,
cord-015684-q10sx1dm	52	12	GPR50	gpr50	FW
cord-015684-q10sx1dm	52	13	(	(	-LRB-
cord-015684-q10sx1dm	53	1	Xq28	Xq28	NNP
cord-015684-q10sx1dm	53	2	)	)	-RRB-
cord-015684-q10sx1dm	53	3	,	,	,
cord-015684-q10sx1dm	53	4	Citron	Citron	NNP
cord-015684-q10sx1dm	53	5	(	(	-LRB-
cord-015684-q10sx1dm	53	6	12q24	12q24	CD
cord-015684-q10sx1dm	53	7	)	)	-RRB-
cord-015684-q10sx1dm	53	8	,	,	,
cord-015684-q10sx1dm	53	9	CHP1.5	CHP1.5	NNP
cord-015684-q10sx1dm	53	10	(	(	-LRB-
cord-015684-q10sx1dm	53	11	18p11.2	18p11.2	NNP
cord-015684-q10sx1dm	53	12	)	)	-RRB-
cord-015684-q10sx1dm	53	13	,	,	,
cord-015684-q10sx1dm	53	14	GCHI	GCHI	NNP
cord-015684-q10sx1dm	53	15	(	(	-LRB-
cord-015684-q10sx1dm	53	16	14q22	14q22	CD
cord-015684-q10sx1dm	53	17	-	-	SYM
cord-015684-q10sx1dm	53	18	24	24	CD
cord-015684-q10sx1dm	53	19	)	)	-RRB-
cord-015684-q10sx1dm	53	20	,	,	,
cord-015684-q10sx1dm	53	21	MLC1	MLC1	NNP
cord-015684-q10sx1dm	53	22	(	(	-LRB-
cord-015684-q10sx1dm	53	23	22q13	22q13	CD
cord-015684-q10sx1dm	53	24	)	)	-RRB-
cord-015684-q10sx1dm	53	25	,	,	,
cord-015684-q10sx1dm	53	26	GABRA5	gabra5	XX
cord-015684-q10sx1dm	54	1	(	(	-LRB-
cord-015684-q10sx1dm	54	2	15q11-q13	15q11-q13	LS
cord-015684-q10sx1dm	54	3	)	)	-RRB-
cord-015684-q10sx1dm	54	4	,	,	,
cord-015684-q10sx1dm	54	5	BCR	BCR	NNP
cord-015684-q10sx1dm	54	6	(	(	-LRB-
cord-015684-q10sx1dm	54	7	22q11	22q11	CD
cord-015684-q10sx1dm	54	8	)	)	-RRB-
cord-015684-q10sx1dm	54	9	,	,	,
cord-015684-q10sx1dm	54	10	CUX2	CUX2	NNP
cord-015684-q10sx1dm	54	11	,	,	,
cord-015684-q10sx1dm	55	1	FLJ32356	FLJ32356	NNP
cord-015684-q10sx1dm	55	2	(	(	-LRB-
cord-015684-q10sx1dm	55	3	12q23-q24	12q23-q24	CD
cord-015684-q10sx1dm	55	4	)	)	-RRB-
cord-015684-q10sx1dm	55	5	,	,	,
cord-015684-q10sx1dm	55	6	and	and	CC
cord-015684-q10sx1dm	55	7	NAPG	NAPG	NNP
cord-015684-q10sx1dm	55	8	(	(	-LRB-
cord-015684-q10sx1dm	55	9	18p11	18p11	CD
cord-015684-q10sx1dm	55	10	)	)	-RRB-
cord-015684-q10sx1dm	55	11	.	.	.
cord-015684-q10sx1dm	56	1	9	9	CD
cord-015684-q10sx1dm	57	1	Another	another	DT
cord-015684-q10sx1dm	57	2	paradigmatic	paradigmatic	JJ
cord-015684-q10sx1dm	57	3	example	example	NN
cord-015684-q10sx1dm	57	4	of	of	IN
cord-015684-q10sx1dm	57	5	heterogeneity	heterogeneity	NN
cord-015684-q10sx1dm	57	6	and	and	CC
cord-015684-q10sx1dm	57	7	complexity	complexity	NN
cord-015684-q10sx1dm	57	8	is	be	VBZ
cord-015684-q10sx1dm	57	9	dementia	dementia	NN
cord-015684-q10sx1dm	57	10	,	,	,
cord-015684-q10sx1dm	57	11	one	one	CD
cord-015684-q10sx1dm	57	12	of	of	IN
cord-015684-q10sx1dm	57	13	the	the	DT
cord-015684-q10sx1dm	57	14	most	most	RBS
cord-015684-q10sx1dm	57	15	heterogeneous	heterogeneous	JJ
cord-015684-q10sx1dm	57	16	disorders	disorder	NNS
cord-015684-q10sx1dm	57	17	of	of	IN
cord-015684-q10sx1dm	57	18	the	the	DT
cord-015684-q10sx1dm	57	19	CNS	CNS	NNP
cord-015684-q10sx1dm	57	20	.	.	.
cord-015684-q10sx1dm	58	1	The	the	DT
cord-015684-q10sx1dm	58	2	genetic	genetic	JJ
cord-015684-q10sx1dm	58	3	defects	defect	NNS
cord-015684-q10sx1dm	58	4	identifi	identifi	NNP
cord-015684-q10sx1dm	58	5	ed	ed	NN
cord-015684-q10sx1dm	58	6	in	in	IN
cord-015684-q10sx1dm	58	7	AD	ad	NN
cord-015684-q10sx1dm	58	8	during	during	IN
cord-015684-q10sx1dm	58	9	the	the	DT
cord-015684-q10sx1dm	58	10	past	past	JJ
cord-015684-q10sx1dm	58	11	25	25	CD
cord-015684-q10sx1dm	58	12	years	year	NNS
cord-015684-q10sx1dm	58	13	can	can	MD
cord-015684-q10sx1dm	58	14	be	be	VB
cord-015684-q10sx1dm	58	15	classifi	classifi	NNP
cord-015684-q10sx1dm	58	16	ed	ed	NN
cord-015684-q10sx1dm	58	17	into	into	IN
cord-015684-q10sx1dm	58	18	three	three	CD
cord-015684-q10sx1dm	58	19	main	main	JJ
cord-015684-q10sx1dm	58	20	categories	category	NNS
cord-015684-q10sx1dm	58	21	:	:	:
cord-015684-q10sx1dm	58	22	(	(	-LRB-
cord-015684-q10sx1dm	58	23	a	a	LS
cord-015684-q10sx1dm	58	24	)	)	-RRB-
cord-015684-q10sx1dm	58	25	Mendelian	mendelian	JJ
cord-015684-q10sx1dm	58	26	or	or	CC
cord-015684-q10sx1dm	58	27	mutational	mutational	JJ
cord-015684-q10sx1dm	58	28	defects	defect	NNS
cord-015684-q10sx1dm	58	29	in	in	IN
cord-015684-q10sx1dm	58	30	genes	gene	NNS
cord-015684-q10sx1dm	58	31	directly	directly	RB
cord-015684-q10sx1dm	58	32	linked	link	VBN
cord-015684-q10sx1dm	58	33	to	to	IN
cord-015684-q10sx1dm	58	34	AD	ad	NN
cord-015684-q10sx1dm	58	35	,	,	,
cord-015684-q10sx1dm	58	36	including	include	VBG
cord-015684-q10sx1dm	58	37	(	(	-LRB-
cord-015684-q10sx1dm	58	38	i	i	NN
cord-015684-q10sx1dm	58	39	)	)	-RRB-
cord-015684-q10sx1dm	58	40	32	32	CD
cord-015684-q10sx1dm	58	41	mutations	mutation	NNS
cord-015684-q10sx1dm	58	42	in	in	IN
cord-015684-q10sx1dm	58	43	the	the	DT
cord-015684-q10sx1dm	58	44	amyloid	amyloid	NN
cord-015684-q10sx1dm	58	45	beta	beta	NN
cord-015684-q10sx1dm	58	46	(	(	-LRB-
cord-015684-q10sx1dm	58	47	Aβ)(ABP	aβ)(abp	NN
cord-015684-q10sx1dm	58	48	)	)	-RRB-
cord-015684-q10sx1dm	58	49	precursor	precursor	NN
cord-015684-q10sx1dm	58	50	protein	protein	NN
cord-015684-q10sx1dm	58	51	(	(	-LRB-
cord-015684-q10sx1dm	58	52	APP	app	NN
cord-015684-q10sx1dm	58	53	)	)	-RRB-
cord-015684-q10sx1dm	58	54	gene	gene	NN
cord-015684-q10sx1dm	58	55	(	(	-LRB-
cord-015684-q10sx1dm	58	56	21q21	21q21	CD
cord-015684-q10sx1dm	58	57	)	)	-RRB-
cord-015684-q10sx1dm	58	58	;	;	:
cord-015684-q10sx1dm	58	59	(	(	-LRB-
cord-015684-q10sx1dm	58	60	ii	ii	NN
cord-015684-q10sx1dm	58	61	)	)	-RRB-
cord-015684-q10sx1dm	58	62	165	165	CD
cord-015684-q10sx1dm	58	63	mutations	mutation	NNS
cord-015684-q10sx1dm	58	64	in	in	IN
cord-015684-q10sx1dm	58	65	the	the	DT
cord-015684-q10sx1dm	58	66	presenilin	presenilin	NN
cord-015684-q10sx1dm	58	67	1	1	CD
cord-015684-q10sx1dm	58	68	(	(	-LRB-
cord-015684-q10sx1dm	58	69	PS1	PS1	NNP
cord-015684-q10sx1dm	58	70	)	)	-RRB-
cord-015684-q10sx1dm	58	71	gene	gene	NN
cord-015684-q10sx1dm	58	72	(	(	-LRB-
cord-015684-q10sx1dm	58	73	14q24.3	14q24.3	CD
cord-015684-q10sx1dm	58	74	)	)	-RRB-
cord-015684-q10sx1dm	58	75	;	;	:
cord-015684-q10sx1dm	58	76	and	and	CC
cord-015684-q10sx1dm	58	77	(	(	-LRB-
cord-015684-q10sx1dm	58	78	iii	iii	NN
cord-015684-q10sx1dm	58	79	)	)	-RRB-
cord-015684-q10sx1dm	59	1	12	12	CD
cord-015684-q10sx1dm	59	2	mutations	mutation	NNS
cord-015684-q10sx1dm	59	3	in	in	IN
cord-015684-q10sx1dm	59	4	the	the	DT
cord-015684-q10sx1dm	59	5	presenilin	presenilin	NN
cord-015684-q10sx1dm	59	6	2	2	CD
cord-015684-q10sx1dm	59	7	(	(	-LRB-
cord-015684-q10sx1dm	59	8	PS2	PS2	NNP
cord-015684-q10sx1dm	59	9	)	)	-RRB-
cord-015684-q10sx1dm	59	10	gene	gene	NN
cord-015684-q10sx1dm	59	11	(	(	-LRB-
cord-015684-q10sx1dm	59	12	1q31-q42	1q31-q42	NNP
cord-015684-q10sx1dm	59	13	)	)	-RRB-
cord-015684-q10sx1dm	59	14	8	8	CD
cord-015684-q10sx1dm	59	15	,	,	,
cord-015684-q10sx1dm	59	16	10	10	CD
cord-015684-q10sx1dm	59	17	,	,	,
cord-015684-q10sx1dm	59	18	13	13	CD
cord-015684-q10sx1dm	60	1	(	(	-LRB-
cord-015684-q10sx1dm	60	2	Table	table	NN
cord-015684-q10sx1dm	60	3	40	40	CD
cord-015684-q10sx1dm	60	4	.1	.1	CD
cord-015684-q10sx1dm	60	5	)	)	-RRB-
cord-015684-q10sx1dm	60	6	.	.	.
cord-015684-q10sx1dm	61	1	(	(	-LRB-
cord-015684-q10sx1dm	61	2	b	b	LS
cord-015684-q10sx1dm	61	3	)	)	-RRB-
cord-015684-q10sx1dm	61	4	Multiple	multiple	JJ
cord-015684-q10sx1dm	61	5	polymorphic	polymorphic	JJ
cord-015684-q10sx1dm	61	6	variants	variant	NNS
cord-015684-q10sx1dm	61	7	of	of	IN
cord-015684-q10sx1dm	61	8	risk	risk	NN
cord-015684-q10sx1dm	61	9	characterized	characterize	VBN
cord-015684-q10sx1dm	61	10	in	in	IN
cord-015684-q10sx1dm	61	11	more	more	JJR
cord-015684-q10sx1dm	61	12	than	than	IN
cord-015684-q10sx1dm	61	13	200	200	CD
cord-015684-q10sx1dm	61	14	different	different	JJ
cord-015684-q10sx1dm	61	15	genes	gene	NNS
cord-015684-q10sx1dm	61	16	distributed	distribute	VBN
cord-015684-q10sx1dm	61	17	across	across	IN
cord-015684-q10sx1dm	61	18	the	the	DT
cord-015684-q10sx1dm	61	19	human	human	JJ
cord-015684-q10sx1dm	61	20	genome	genome	NN
cord-015684-q10sx1dm	61	21	can	can	MD
cord-015684-q10sx1dm	61	22	increase	increase	VB
cord-015684-q10sx1dm	61	23	neuronal	neuronal	JJ
cord-015684-q10sx1dm	61	24	vulnerability	vulnerability	NN
cord-015684-q10sx1dm	61	25	to	to	IN
cord-015684-q10sx1dm	61	26	premature	premature	JJ
cord-015684-q10sx1dm	61	27	death	death	NN
cord-015684-q10sx1dm	61	28	8	8	CD
cord-015684-q10sx1dm	62	1	(	(	-LRB-
cord-015684-q10sx1dm	62	2	Table	table	NN
cord-015684-q10sx1dm	62	3	40	40	CD
cord-015684-q10sx1dm	62	4	.1	.1	CD
cord-015684-q10sx1dm	62	5	)	)	-RRB-
cord-015684-q10sx1dm	62	6	.	.	.
cord-015684-q10sx1dm	63	1	Among	among	IN
cord-015684-q10sx1dm	63	2	these	these	DT
cord-015684-q10sx1dm	63	3	genes	gene	NNS
cord-015684-q10sx1dm	63	4	of	of	IN
cord-015684-q10sx1dm	63	5	susceptibility	susceptibility	NN
cord-015684-q10sx1dm	63	6	,	,	,
cord-015684-q10sx1dm	63	7	the	the	DT
cord-015684-q10sx1dm	63	8	apolipoprotein	apolipoprotein	NN
cord-015684-q10sx1dm	63	9	E	e	NN
cord-015684-q10sx1dm	63	10	(	(	-LRB-
cord-015684-q10sx1dm	63	11	APOE	APOE	NNP
cord-015684-q10sx1dm	63	12	)	)	-RRB-
cord-015684-q10sx1dm	63	13	gene	gene	NN
cord-015684-q10sx1dm	63	14	(	(	-LRB-
cord-015684-q10sx1dm	63	15	19q13.2	19q13.2	NNP
cord-015684-q10sx1dm	63	16	)	)	-RRB-
cord-015684-q10sx1dm	63	17	is	be	VBZ
cord-015684-q10sx1dm	63	18	the	the	DT
cord-015684-q10sx1dm	63	19	most	most	RBS
cord-015684-q10sx1dm	63	20	prevalent	prevalent	JJ
cord-015684-q10sx1dm	63	21	as	as	IN
cord-015684-q10sx1dm	63	22	a	a	DT
cord-015684-q10sx1dm	63	23	risk	risk	NN
cord-015684-q10sx1dm	63	24	factor	factor	NN
cord-015684-q10sx1dm	63	25	for	for	IN
cord-015684-q10sx1dm	63	26	AD	ad	NN
cord-015684-q10sx1dm	63	27	,	,	,
cord-015684-q10sx1dm	63	28	especially	especially	RB
cord-015684-q10sx1dm	63	29	in	in	IN
cord-015684-q10sx1dm	63	30	those	those	DT
cord-015684-q10sx1dm	63	31	subjects	subject	NNS
cord-015684-q10sx1dm	63	32	harbouring	harbour	VBG
cord-015684-q10sx1dm	63	33	the	the	DT
cord-015684-q10sx1dm	63	34	APOE-4	APOE-4	NNP
cord-015684-q10sx1dm	63	35	allele	allele	NN
cord-015684-q10sx1dm	63	36	,	,	,
cord-015684-q10sx1dm	63	37	whereas	whereas	IN
cord-015684-q10sx1dm	63	38	carriers	carrier	NNS
cord-015684-q10sx1dm	63	39	of	of	IN
cord-015684-q10sx1dm	63	40	the	the	DT
cord-015684-q10sx1dm	63	41	APOE-2	APOE-2	NNP
cord-015684-q10sx1dm	63	42	allele	allele	NN
cord-015684-q10sx1dm	63	43	might	may	MD
cord-015684-q10sx1dm	63	44	be	be	VB
cord-015684-q10sx1dm	63	45	protected	protect	VBN
cord-015684-q10sx1dm	63	46	against	against	IN
cord-015684-q10sx1dm	63	47	dementia	dementia	NN
cord-015684-q10sx1dm	63	48	.	.	.
cord-015684-q10sx1dm	64	1	8	8	CD
cord-015684-q10sx1dm	64	2	APOE	apoe	NN
cord-015684-q10sx1dm	64	3	-	-	HYPH
cord-015684-q10sx1dm	64	4	related	relate	VBN
cord-015684-q10sx1dm	64	5	pathogenic	pathogenic	JJ
cord-015684-q10sx1dm	64	6	mechanisms	mechanism	NNS
cord-015684-q10sx1dm	64	7	are	be	VBP
cord-015684-q10sx1dm	64	8	also	also	RB
cord-015684-q10sx1dm	64	9	associated	associate	VBN
cord-015684-q10sx1dm	64	10	with	with	IN
cord-015684-q10sx1dm	64	11	brain	brain	NN
cord-015684-q10sx1dm	64	12	aging	age	VBG
cord-015684-q10sx1dm	64	13	and	and	CC
cord-015684-q10sx1dm	64	14	with	with	IN
cord-015684-q10sx1dm	64	15	the	the	DT
cord-015684-q10sx1dm	64	16	neuropathological	neuropathological	NNP
cord-015684-q10sx1dm	64	17	hallmarks	hallmark	NNS
cord-015684-q10sx1dm	64	18	of	of	IN
cord-015684-q10sx1dm	64	19	AD	ad	NN
cord-015684-q10sx1dm	64	20	.	.	.
cord-015684-q10sx1dm	65	1	8	8	CD
cord-015684-q10sx1dm	66	1	(	(	-LRB-
cord-015684-q10sx1dm	66	2	c	c	NN
cord-015684-q10sx1dm	66	3	)	)	-RRB-
cord-015684-q10sx1dm	67	1	Diverse	diverse	JJ
cord-015684-q10sx1dm	67	2	mutations	mutation	NNS
cord-015684-q10sx1dm	67	3	located	locate	VBN
cord-015684-q10sx1dm	67	4	in	in	IN
cord-015684-q10sx1dm	67	5	mitochondrial	mitochondrial	JJ
cord-015684-q10sx1dm	67	6	DNA	dna	NN
cord-015684-q10sx1dm	67	7	(	(	-LRB-
cord-015684-q10sx1dm	67	8	mtDNA	mtDNA	NNP
cord-015684-q10sx1dm	67	9	)	)	-RRB-
cord-015684-q10sx1dm	67	10	through	through	IN
cord-015684-q10sx1dm	67	11	heteroplasmic	heteroplasmic	NNP
cord-015684-q10sx1dm	67	12	transmission	transmission	NN
cord-015684-q10sx1dm	67	13	can	can	MD
cord-015684-q10sx1dm	67	14	infl	infl	XX
cord-015684-q10sx1dm	67	15	uence	uence	NN
cord-015684-q10sx1dm	67	16	aging	aging	NN
cord-015684-q10sx1dm	67	17	and	and	CC
cord-015684-q10sx1dm	67	18	oxidative	oxidative	JJ
cord-015684-q10sx1dm	67	19	stress	stress	NN
cord-015684-q10sx1dm	67	20	conditions	condition	NNS
cord-015684-q10sx1dm	67	21	,	,	,
cord-015684-q10sx1dm	67	22	conferring	confer	VBG
cord-015684-q10sx1dm	67	23	phenotypic	phenotypic	JJ
cord-015684-q10sx1dm	67	24	heterogeneity	heterogeneity	NN
cord-015684-q10sx1dm	67	25	.	.	.
cord-015684-q10sx1dm	68	1	8	8	CD
cord-015684-q10sx1dm	68	2	,	,	,
cord-015684-q10sx1dm	68	3	14	14	CD
cord-015684-q10sx1dm	68	4	,	,	,
cord-015684-q10sx1dm	68	5	15	15	CD
cord-015684-q10sx1dm	69	1	It	-PRON-	PRP
cord-015684-q10sx1dm	69	2	is	be	VBZ
cord-015684-q10sx1dm	69	3	also	also	RB
cord-015684-q10sx1dm	69	4	likely	likely	JJ
cord-015684-q10sx1dm	69	5	that	that	IN
cord-015684-q10sx1dm	69	6	defective	defective	JJ
cord-015684-q10sx1dm	69	7	functions	function	NNS
cord-015684-q10sx1dm	69	8	of	of	IN
cord-015684-q10sx1dm	69	9	genes	gene	NNS
cord-015684-q10sx1dm	69	10	associated	associate	VBN
cord-015684-q10sx1dm	69	11	with	with	IN
cord-015684-q10sx1dm	69	12	longevity	longevity	NN
cord-015684-q10sx1dm	69	13	may	may	MD
cord-015684-q10sx1dm	69	14	infl	infl	VB
cord-015684-q10sx1dm	69	15	uence	uence	NN
cord-015684-q10sx1dm	69	16	premature	premature	JJ
cord-015684-q10sx1dm	69	17	neuronal	neuronal	JJ
cord-015684-q10sx1dm	69	18	survival	survival	NN
cord-015684-q10sx1dm	69	19	,	,	,
cord-015684-q10sx1dm	69	20	since	since	IN
cord-015684-q10sx1dm	69	21	neurons	neuron	NNS
cord-015684-q10sx1dm	69	22	are	be	VBP
cord-015684-q10sx1dm	69	23	potential	potential	JJ
cord-015684-q10sx1dm	69	24	pacemakers	pacemaker	NNS
cord-015684-q10sx1dm	69	25	defi	defi	NNP
cord-015684-q10sx1dm	69	26	ning	ning	NNP
cord-015684-q10sx1dm	69	27	life	life	NN
cord-015684-q10sx1dm	69	28	span	span	NN
cord-015684-q10sx1dm	69	29	in	in	IN
cord-015684-q10sx1dm	69	30	mammals	mammal	NNS
cord-015684-q10sx1dm	69	31	.	.	.
cord-015684-q10sx1dm	70	1	8	8	CD
cord-015684-q10sx1dm	71	1	All	all	PDT
cord-015684-q10sx1dm	71	2	these	these	DT
cord-015684-q10sx1dm	71	3	genetic	genetic	JJ
cord-015684-q10sx1dm	71	4	factors	factor	NNS
cord-015684-q10sx1dm	71	5	may	may	MD
cord-015684-q10sx1dm	71	6	interact	interact	VB
cord-015684-q10sx1dm	71	7	in	in	IN
cord-015684-q10sx1dm	71	8	still	still	RB
cord-015684-q10sx1dm	71	9	unknown	unknown	JJ
cord-015684-q10sx1dm	71	10	genetic	genetic	JJ
cord-015684-q10sx1dm	71	11	networks	network	NNS
cord-015684-q10sx1dm	71	12	leading	lead	VBG
cord-015684-q10sx1dm	71	13	to	to	IN
cord-015684-q10sx1dm	71	14	a	a	DT
cord-015684-q10sx1dm	71	15	cascade	cascade	NN
cord-015684-q10sx1dm	71	16	of	of	IN
cord-015684-q10sx1dm	71	17	pathogenic	pathogenic	JJ
cord-015684-q10sx1dm	71	18	events	event	NNS
cord-015684-q10sx1dm	71	19	characterized	characterize	VBN
cord-015684-q10sx1dm	71	20	by	by	IN
cord-015684-q10sx1dm	71	21	abnormal	abnormal	JJ
cord-015684-q10sx1dm	71	22	protein	protein	NN
cord-015684-q10sx1dm	71	23	processing	processing	NN
cord-015684-q10sx1dm	71	24	and	and	CC
cord-015684-q10sx1dm	71	25	misfolding	misfolde	VBG
cord-015684-q10sx1dm	71	26	with	with	IN
cord-015684-q10sx1dm	71	27	subsequent	subsequent	JJ
cord-015684-q10sx1dm	71	28	accumulation	accumulation	NN
cord-015684-q10sx1dm	71	29	of	of	IN
cord-015684-q10sx1dm	71	30	abnormal	abnormal	JJ
cord-015684-q10sx1dm	71	31	proteins	protein	NNS
cord-015684-q10sx1dm	71	32	(	(	-LRB-
cord-015684-q10sx1dm	71	33	conformational	conformational	JJ
cord-015684-q10sx1dm	71	34	changes	change	NNS
cord-015684-q10sx1dm	71	35	)	)	-RRB-
cord-015684-q10sx1dm	71	36	,	,	,
cord-015684-q10sx1dm	71	37	ubiquitin	ubiquitin	NN
cord-015684-q10sx1dm	71	38	-	-	HYPH
cord-015684-q10sx1dm	71	39	proteasome	proteasome	VBN
cord-015684-q10sx1dm	71	40	system	system	NN
cord-015684-q10sx1dm	71	41	dysfunction	dysfunction	NN
cord-015684-q10sx1dm	71	42	,	,	,
cord-015684-q10sx1dm	71	43	excitotoxic	excitotoxic	JJ
cord-015684-q10sx1dm	71	44	reactions	reaction	NNS
cord-015684-q10sx1dm	71	45	,	,	,
cord-015684-q10sx1dm	71	46	oxidative	oxidative	JJ
cord-015684-q10sx1dm	71	47	and	and	CC
cord-015684-q10sx1dm	71	48	nitrosative	nitrosative	JJ
cord-015684-q10sx1dm	71	49	stress	stress	NN
cord-015684-q10sx1dm	71	50	,	,	,
cord-015684-q10sx1dm	71	51	mitochondrial	mitochondrial	JJ
cord-015684-q10sx1dm	71	52	injury	injury	NN
cord-015684-q10sx1dm	71	53	,	,	,
cord-015684-q10sx1dm	71	54	synaptic	synaptic	JJ
cord-015684-q10sx1dm	71	55	failure	failure	NN
cord-015684-q10sx1dm	71	56	,	,	,
cord-015684-q10sx1dm	71	57	altered	alter	VBN
cord-015684-q10sx1dm	71	58	metal	metal	NN
cord-015684-q10sx1dm	71	59	homeostasis	homeostasis	NN
cord-015684-q10sx1dm	71	60	,	,	,
cord-015684-q10sx1dm	71	61	dysfunction	dysfunction	NN
cord-015684-q10sx1dm	71	62	of	of	IN
cord-015684-q10sx1dm	71	63	axonal	axonal	JJ
cord-015684-q10sx1dm	71	64	and	and	CC
cord-015684-q10sx1dm	71	65	dendritic	dendritic	JJ
cord-015684-q10sx1dm	71	66	transport	transport	NN
cord-015684-q10sx1dm	71	67	,	,	,
cord-015684-q10sx1dm	71	68	and	and	CC
cord-015684-q10sx1dm	71	69	chaperone	chaperone	NN
cord-015684-q10sx1dm	71	70	misoperation	misoperation	NN
cord-015684-q10sx1dm	71	71	8,16	8,16	CD
cord-015684-q10sx1dm	71	72	-	-	HYPH
cord-015684-q10sx1dm	71	73	20	20	CD
cord-015684-q10sx1dm	72	1	(	(	-LRB-
cord-015684-q10sx1dm	72	2	Fig	Fig	NNP
cord-015684-q10sx1dm	72	3	.	.	.
cord-015684-q10sx1dm	72	4	40.1	40.1	CD
cord-015684-q10sx1dm	72	5	)	)	-RRB-
cord-015684-q10sx1dm	72	6	.	.	.
cord-015684-q10sx1dm	73	1	These	these	DT
cord-015684-q10sx1dm	73	2	pathogenic	pathogenic	JJ
cord-015684-q10sx1dm	73	3	events	event	NNS
cord-015684-q10sx1dm	73	4	may	may	MD
cord-015684-q10sx1dm	73	5	exert	exert	VB
cord-015684-q10sx1dm	73	6	an	an	DT
cord-015684-q10sx1dm	73	7	additive	additive	NN
cord-015684-q10sx1dm	73	8	effect	effect	NN
cord-015684-q10sx1dm	73	9	,	,	,
cord-015684-q10sx1dm	73	10	converging	converge	VBG
cord-015684-q10sx1dm	73	11	in	in	IN
cord-015684-q10sx1dm	73	12	fi	fi	NNP
cord-015684-q10sx1dm	73	13	nal	nal	NNP
cord-015684-q10sx1dm	73	14	pathways	pathway	NNS
cord-015684-q10sx1dm	73	15	leading	lead	VBG
cord-015684-q10sx1dm	73	16	to	to	IN
cord-015684-q10sx1dm	73	17	premature	premature	JJ
cord-015684-q10sx1dm	73	18	neuronal	neuronal	JJ
cord-015684-q10sx1dm	73	19	death	death	NN
cord-015684-q10sx1dm	73	20	.	.	.
cord-015684-q10sx1dm	74	1	Some	some	DT
cord-015684-q10sx1dm	74	2	of	of	IN
cord-015684-q10sx1dm	74	3	these	these	DT
cord-015684-q10sx1dm	74	4	mechanisms	mechanism	NNS
cord-015684-q10sx1dm	74	5	are	be	VBP
cord-015684-q10sx1dm	74	6	common	common	JJ
cord-015684-q10sx1dm	74	7	to	to	IN
cord-015684-q10sx1dm	74	8	several	several	JJ
cord-015684-q10sx1dm	74	9	neurodegenerative	neurodegenerative	JJ
cord-015684-q10sx1dm	74	10	disorders	disorder	NNS
cord-015684-q10sx1dm	74	11	which	which	WDT
cord-015684-q10sx1dm	74	12	differ	differ	VBP
cord-015684-q10sx1dm	74	13	depending	depend	VBG
cord-015684-q10sx1dm	74	14	upon	upon	IN
cord-015684-q10sx1dm	74	15	the	the	DT
cord-015684-q10sx1dm	74	16	gene(s	gene(s	NNP
cord-015684-q10sx1dm	74	17	)	)	-RRB-
cord-015684-q10sx1dm	74	18	affected	affect	VBD
cord-015684-q10sx1dm	74	19	and	and	CC
cord-015684-q10sx1dm	74	20	the	the	DT
cord-015684-q10sx1dm	74	21	involvement	involvement	NN
cord-015684-q10sx1dm	74	22	of	of	IN
cord-015684-q10sx1dm	74	23	specifi	specifi	NNP
cord-015684-q10sx1dm	74	24	c	c	NNP
cord-015684-q10sx1dm	74	25	genetic	genetic	JJ
cord-015684-q10sx1dm	74	26	networks	network	NNS
cord-015684-q10sx1dm	74	27	,	,	,
cord-015684-q10sx1dm	74	28	together	together	RB
cord-015684-q10sx1dm	74	29	with	with	IN
cord-015684-q10sx1dm	74	30	cerebrovascular	cerebrovascular	JJ
cord-015684-q10sx1dm	74	31	factors	factor	NNS
cord-015684-q10sx1dm	74	32	,	,	,
cord-015684-q10sx1dm	74	33	epigenetic	epigenetic	JJ
cord-015684-q10sx1dm	74	34	factors	factor	NNS
cord-015684-q10sx1dm	74	35	(	(	-LRB-
cord-015684-q10sx1dm	74	36	DNA	dna	NN
cord-015684-q10sx1dm	74	37	methylation	methylation	NN
cord-015684-q10sx1dm	74	38	)	)	-RRB-
cord-015684-q10sx1dm	74	39	and	and	CC
cord-015684-q10sx1dm	74	40	environmental	environmental	JJ
cord-015684-q10sx1dm	74	41	conditions	condition	NNS
cord-015684-q10sx1dm	74	42	(	(	-LRB-
cord-015684-q10sx1dm	74	43	nutrition	nutrition	NN
cord-015684-q10sx1dm	74	44	,	,	,
cord-015684-q10sx1dm	74	45	toxicity	toxicity	NN
cord-015684-q10sx1dm	74	46	,	,	,
cord-015684-q10sx1dm	74	47	social	social	JJ
cord-015684-q10sx1dm	74	48	factors	factor	NNS
cord-015684-q10sx1dm	74	49	,	,	,
cord-015684-q10sx1dm	74	50	etc	etc	FW
cord-015684-q10sx1dm	74	51	)	)	-RRB-
cord-015684-q10sx1dm	74	52	.	.	.
cord-015684-q10sx1dm	75	1	8	8	CD
cord-015684-q10sx1dm	75	2	,	,	,
cord-015684-q10sx1dm	75	3	[	[	-LRB-
cord-015684-q10sx1dm	75	4	16	16	CD
cord-015684-q10sx1dm	75	5	]	]	-RRB-
cord-015684-q10sx1dm	75	6	[	[	-LRB-
cord-015684-q10sx1dm	75	7	17	17	CD
cord-015684-q10sx1dm	75	8	]	]	-RRB-
cord-015684-q10sx1dm	75	9	[	[	-LRB-
cord-015684-q10sx1dm	75	10	18	18	CD
cord-015684-q10sx1dm	75	11	]	]	-RRB-
cord-015684-q10sx1dm	75	12	[	[	-LRB-
cord-015684-q10sx1dm	75	13	19	19	CD
cord-015684-q10sx1dm	75	14	]	]	-RRB-
cord-015684-q10sx1dm	76	1	[	[	-LRB-
cord-015684-q10sx1dm	76	2	20	20	CD
cord-015684-q10sx1dm	76	3	]	]	-RRB-
cord-015684-q10sx1dm	76	4	[	[	-LRB-
cord-015684-q10sx1dm	76	5	21	21	CD
cord-015684-q10sx1dm	76	6	]	]	-RRB-
cord-015684-q10sx1dm	77	1	[	[	-LRB-
cord-015684-q10sx1dm	77	2	22	22	CD
cord-015684-q10sx1dm	77	3	]	]	-RRB-
cord-015684-q10sx1dm	78	1	The	the	DT
cord-015684-q10sx1dm	78	2	higher	high	JJR
cord-015684-q10sx1dm	78	3	the	the	DT
cord-015684-q10sx1dm	78	4	number	number	NN
cord-015684-q10sx1dm	78	5	of	of	IN
cord-015684-q10sx1dm	78	6	genes	gene	NNS
cord-015684-q10sx1dm	78	7	involved	involve	VBN
cord-015684-q10sx1dm	78	8	in	in	IN
cord-015684-q10sx1dm	78	9	AD	ad	NN
cord-015684-q10sx1dm	78	10	pathogenesis	pathogenesis	NN
cord-015684-q10sx1dm	78	11	,	,	,
cord-015684-q10sx1dm	78	12	the	the	DT
cord-015684-q10sx1dm	78	13	earlier	early	JJR
cord-015684-q10sx1dm	78	14	the	the	DT
cord-015684-q10sx1dm	78	15	onset	onset	NN
cord-015684-q10sx1dm	78	16	of	of	IN
cord-015684-q10sx1dm	78	17	the	the	DT
cord-015684-q10sx1dm	78	18	disease	disease	NN
cord-015684-q10sx1dm	78	19	,	,	,
cord-015684-q10sx1dm	78	20	the	the	DT
cord-015684-q10sx1dm	78	21	faster	fast	RBR
cord-015684-q10sx1dm	78	22	its	-PRON-	PRP$
cord-015684-q10sx1dm	78	23	clinical	clinical	JJ
cord-015684-q10sx1dm	78	24	course	course	NN
cord-015684-q10sx1dm	78	25	,	,	,
cord-015684-q10sx1dm	78	26	and	and	CC
cord-015684-q10sx1dm	78	27	the	the	DT
cord-015684-q10sx1dm	78	28	poorer	poor	JJR
cord-015684-q10sx1dm	78	29	its	-PRON-	PRP$
cord-015684-q10sx1dm	78	30	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	78	31	outcome	outcome	NN
cord-015684-q10sx1dm	78	32	.	.	.
cord-015684-q10sx1dm	79	1	8	8	CD
cord-015684-q10sx1dm	79	2	,	,	,
cord-015684-q10sx1dm	79	3	[	[	-LRB-
cord-015684-q10sx1dm	79	4	16	16	CD
cord-015684-q10sx1dm	79	5	]	]	-RRB-
cord-015684-q10sx1dm	80	1	[	[	-LRB-
cord-015684-q10sx1dm	80	2	17	17	CD
cord-015684-q10sx1dm	80	3	]	]	-RRB-
cord-015684-q10sx1dm	80	4	[	[	-LRB-
cord-015684-q10sx1dm	80	5	18	18	CD
cord-015684-q10sx1dm	80	6	]	]	-RRB-
cord-015684-q10sx1dm	80	7	[	[	-LRB-
cord-015684-q10sx1dm	80	8	19	19	CD
cord-015684-q10sx1dm	80	9	]	]	-RRB-
cord-015684-q10sx1dm	80	10	[	[	-LRB-
cord-015684-q10sx1dm	80	11	20	20	CD
cord-015684-q10sx1dm	80	12	]	]	-RRB-
cord-015684-q10sx1dm	80	13	High	high	JJ
cord-015684-q10sx1dm	80	14	throughput	throughput	NN
cord-015684-q10sx1dm	80	15	microarray	microarray	NN
cord-015684-q10sx1dm	80	16	gene	gene	NN
cord-015684-q10sx1dm	80	17	expression	expression	NN
cord-015684-q10sx1dm	81	1	profi	profi	NNP
cord-015684-q10sx1dm	81	2	ling	ling	NNP
cord-015684-q10sx1dm	81	3	is	be	VBZ
cord-015684-q10sx1dm	81	4	an	an	DT
cord-015684-q10sx1dm	81	5	effective	effective	JJ
cord-015684-q10sx1dm	81	6	approach	approach	NN
cord-015684-q10sx1dm	81	7	for	for	IN
cord-015684-q10sx1dm	81	8	the	the	DT
cord-015684-q10sx1dm	81	9	identifi	identifi	NNP
cord-015684-q10sx1dm	81	10	cation	cation	NNP
cord-015684-q10sx1dm	81	11	of	of	IN
cord-015684-q10sx1dm	81	12	candidate	candidate	NN
cord-015684-q10sx1dm	81	13	genes	gene	NNS
cord-015684-q10sx1dm	81	14	and	and	CC
cord-015684-q10sx1dm	81	15	associated	associate	VBD
cord-015684-q10sx1dm	81	16	molecular	molecular	JJ
cord-015684-q10sx1dm	81	17	pathways	pathway	NNS
cord-015684-q10sx1dm	81	18	implicated	implicate	VBN
cord-015684-q10sx1dm	81	19	in	in	IN
cord-015684-q10sx1dm	81	20	a	a	DT
cord-015684-q10sx1dm	81	21	wide	wide	JJ
cord-015684-q10sx1dm	81	22	variety	variety	NN
cord-015684-q10sx1dm	81	23	of	of	IN
cord-015684-q10sx1dm	81	24	biological	biological	JJ
cord-015684-q10sx1dm	81	25	processes	process	NNS
cord-015684-q10sx1dm	81	26	or	or	CC
cord-015684-q10sx1dm	81	27	disease	disease	NN
cord-015684-q10sx1dm	81	28	states	state	NNS
cord-015684-q10sx1dm	81	29	.	.	.
cord-015684-q10sx1dm	82	1	The	the	DT
cord-015684-q10sx1dm	82	2	cellular	cellular	JJ
cord-015684-q10sx1dm	82	3	complexity	complexity	NN
cord-015684-q10sx1dm	82	4	of	of	IN
cord-015684-q10sx1dm	82	5	the	the	DT
cord-015684-q10sx1dm	82	6	CNS	CNS	NNP
cord-015684-q10sx1dm	82	7	(	(	-LRB-
cord-015684-q10sx1dm	82	8	with	with	IN
cord-015684-q10sx1dm	82	9	10	10	CD
cord-015684-q10sx1dm	82	10	3	3	CD
cord-015684-q10sx1dm	82	11	different	different	JJ
cord-015684-q10sx1dm	82	12	cell	cell	NN
cord-015684-q10sx1dm	82	13	types	type	NNS
cord-015684-q10sx1dm	82	14	)	)	-RRB-
cord-015684-q10sx1dm	82	15	and	and	CC
cord-015684-q10sx1dm	82	16	synapses	synapsis	NNS
cord-015684-q10sx1dm	82	17	(	(	-LRB-
cord-015684-q10sx1dm	82	18	with	with	IN
cord-015684-q10sx1dm	82	19	each	each	DT
cord-015684-q10sx1dm	82	20	of	of	IN
cord-015684-q10sx1dm	82	21	the	the	DT
cord-015684-q10sx1dm	82	22	10	10	CD
cord-015684-q10sx1dm	82	23	11	11	CD
cord-015684-q10sx1dm	82	24	neurons	neuron	NNS
cord-015684-q10sx1dm	82	25	in	in	IN
cord-015684-q10sx1dm	82	26	the	the	DT
cord-015684-q10sx1dm	82	27	brain	brain	NN
cord-015684-q10sx1dm	82	28	having	have	VBG
cord-015684-q10sx1dm	82	29	around	around	RB
cord-015684-q10sx1dm	82	30	10	10	CD
cord-015684-q10sx1dm	82	31	3	3	CD
cord-015684-q10sx1dm	82	32	-10	-10	SYM
cord-015684-q10sx1dm	82	33	4	4	CD
cord-015684-q10sx1dm	82	34	synapses	synapsis	NNS
cord-015684-q10sx1dm	82	35	with	with	IN
cord-015684-q10sx1dm	82	36	a	a	DT
cord-015684-q10sx1dm	82	37	complex	complex	JJ
cord-015684-q10sx1dm	82	38	multiprotein	multiprotein	NNP
cord-015684-q10sx1dm	82	39	structure	structure	NN
cord-015684-q10sx1dm	82	40	integrated	integrate	VBN
cord-015684-q10sx1dm	82	41	by	by	IN
cord-015684-q10sx1dm	82	42	10	10	CD
cord-015684-q10sx1dm	82	43	3	3	CD
cord-015684-q10sx1dm	82	44	different	different	JJ
cord-015684-q10sx1dm	82	45	proteins	protein	NNS
cord-015684-q10sx1dm	82	46	)	)	-RRB-
cord-015684-q10sx1dm	82	47	requires	require	VBZ
cord-015684-q10sx1dm	82	48	a	a	DT
cord-015684-q10sx1dm	82	49	very	very	RB
cord-015684-q10sx1dm	82	50	powerful	powerful	JJ
cord-015684-q10sx1dm	82	51	technology	technology	NN
cord-015684-q10sx1dm	82	52	for	for	IN
cord-015684-q10sx1dm	82	53	gene	gene	NN
cord-015684-q10sx1dm	82	54	expression	expression	NN
cord-015684-q10sx1dm	82	55	profi	profi	NNP
cord-015684-q10sx1dm	82	56	ling	ling	NNP
cord-015684-q10sx1dm	82	57	,	,	,
cord-015684-q10sx1dm	82	58	which	which	WDT
cord-015684-q10sx1dm	82	59	is	be	VBZ
cord-015684-q10sx1dm	82	60	still	still	RB
cord-015684-q10sx1dm	82	61	in	in	IN
cord-015684-q10sx1dm	82	62	the	the	DT
cord-015684-q10sx1dm	82	63	very	very	RB
cord-015684-q10sx1dm	82	64	early	early	JJ
cord-015684-q10sx1dm	82	65	stages	stage	NNS
cord-015684-q10sx1dm	82	66	and	and	CC
cord-015684-q10sx1dm	82	67	is	be	VBZ
cord-015684-q10sx1dm	82	68	not	not	RB
cord-015684-q10sx1dm	82	69	devoid	devoid	JJ
cord-015684-q10sx1dm	82	70	of	of	IN
cord-015684-q10sx1dm	82	71	technical	technical	JJ
cord-015684-q10sx1dm	82	72	obstacles	obstacle	NNS
cord-015684-q10sx1dm	82	73	and	and	CC
cord-015684-q10sx1dm	82	74	limitations	limitation	NNS
cord-015684-q10sx1dm	82	75	.	.	.
cord-015684-q10sx1dm	83	1	23	23	CD
cord-015684-q10sx1dm	83	2	Transcripts	transcript	NNS
cord-015684-q10sx1dm	83	3	of	of	IN
cord-015684-q10sx1dm	83	4	16,896	16,896	CD
cord-015684-q10sx1dm	83	5	genes	gene	NNS
cord-015684-q10sx1dm	83	6	have	have	VBP
cord-015684-q10sx1dm	83	7	been	be	VBN
cord-015684-q10sx1dm	83	8	measured	measure	VBN
cord-015684-q10sx1dm	83	9	in	in	IN
cord-015684-q10sx1dm	83	10	different	different	JJ
cord-015684-q10sx1dm	83	11	CNS	CNS	NNP
cord-015684-q10sx1dm	83	12	regions	region	NNS
cord-015684-q10sx1dm	83	13	.	.	.
cord-015684-q10sx1dm	84	1	Each	each	DT
cord-015684-q10sx1dm	84	2	region	region	NN
cord-015684-q10sx1dm	84	3	possess	possess	VBP
cord-015684-q10sx1dm	84	4	its	-PRON-	PRP$
cord-015684-q10sx1dm	84	5	own	own	JJ
cord-015684-q10sx1dm	84	6	unique	unique	JJ
cord-015684-q10sx1dm	84	7	transcriptome	transcriptome	NN
cord-015684-q10sx1dm	84	8	fi	fi	NN
cord-015684-q10sx1dm	84	9	ngerprint	ngerprint	NNP
cord-015684-q10sx1dm	84	10	that	that	WDT
cord-015684-q10sx1dm	84	11	is	be	VBZ
cord-015684-q10sx1dm	84	12	independent	independent	JJ
cord-015684-q10sx1dm	84	13	of	of	IN
cord-015684-q10sx1dm	84	14	age	age	NN
cord-015684-q10sx1dm	84	15	,	,	,
cord-015684-q10sx1dm	84	16	gender	gender	NN
cord-015684-q10sx1dm	84	17	and	and	CC
cord-015684-q10sx1dm	84	18	energy	energy	NN
cord-015684-q10sx1dm	84	19	intake	intake	NN
cord-015684-q10sx1dm	84	20	.	.	.
cord-015684-q10sx1dm	85	1	Less	Less	JJR
cord-015684-q10sx1dm	85	2	than	than	IN
cord-015684-q10sx1dm	85	3	10	10	CD
cord-015684-q10sx1dm	85	4	%	%	NN
cord-015684-q10sx1dm	85	5	of	of	IN
cord-015684-q10sx1dm	85	6	genes	gene	NNS
cord-015684-q10sx1dm	85	7	are	be	VBP
cord-015684-q10sx1dm	85	8	affected	affect	VBN
cord-015684-q10sx1dm	85	9	by	by	IN
cord-015684-q10sx1dm	85	10	age	age	NN
cord-015684-q10sx1dm	85	11	,	,	,
cord-015684-q10sx1dm	85	12	diet	diet	NN
cord-015684-q10sx1dm	85	13	or	or	CC
cord-015684-q10sx1dm	85	14	gender	gender	NN
cord-015684-q10sx1dm	85	15	,	,	,
cord-015684-q10sx1dm	85	16	with	with	IN
cord-015684-q10sx1dm	85	17	most	most	JJS
cord-015684-q10sx1dm	85	18	of	of	IN
cord-015684-q10sx1dm	85	19	these	these	DT
cord-015684-q10sx1dm	85	20	changes	change	NNS
cord-015684-q10sx1dm	85	21	occurring	occur	VBG
cord-015684-q10sx1dm	85	22	between	between	IN
cord-015684-q10sx1dm	85	23	middle	middle	JJ
cord-015684-q10sx1dm	85	24	and	and	CC
cord-015684-q10sx1dm	85	25	old	old	JJ
cord-015684-q10sx1dm	85	26	age	age	NN
cord-015684-q10sx1dm	85	27	.	.	.
cord-015684-q10sx1dm	86	1	Gender	gender	NN
cord-015684-q10sx1dm	86	2	and	and	CC
cord-015684-q10sx1dm	86	3	energy	energy	NN
cord-015684-q10sx1dm	86	4	restriction	restriction	NN
cord-015684-q10sx1dm	86	5	have	have	VBP
cord-015684-q10sx1dm	86	6	robust	robust	JJ
cord-015684-q10sx1dm	86	7	infl	infl	NN
cord-015684-q10sx1dm	86	8	uences	uence	NNS
cord-015684-q10sx1dm	86	9	on	on	IN
cord-015684-q10sx1dm	86	10	the	the	DT
cord-015684-q10sx1dm	86	11	hippocampal	hippocampal	JJ
cord-015684-q10sx1dm	86	12	transcriptome	transcriptome	NN
cord-015684-q10sx1dm	86	13	of	of	IN
cord-015684-q10sx1dm	86	14	middle	middle	NN
cord-015684-q10sx1dm	86	15	-	-	HYPH
cord-015684-q10sx1dm	86	16	aged	aged	JJ
cord-015684-q10sx1dm	86	17	animals	animal	NNS
cord-015684-q10sx1dm	86	18	.	.	.
cord-015684-q10sx1dm	87	1	Prominent	prominent	JJ
cord-015684-q10sx1dm	87	2	functional	functional	JJ
cord-015684-q10sx1dm	87	3	groups	group	NNS
cord-015684-q10sx1dm	87	4	of	of	IN
cord-015684-q10sx1dm	87	5	age	age	NN
cord-015684-q10sx1dm	87	6	-	-	HYPH
cord-015684-q10sx1dm	87	7	and	and	CC
cord-015684-q10sx1dm	87	8	energy	energy	NN
cord-015684-q10sx1dm	87	9	-	-	HYPH
cord-015684-q10sx1dm	87	10	sensitive	sensitive	JJ
cord-015684-q10sx1dm	87	11	genes	gene	NNS
cord-015684-q10sx1dm	87	12	are	be	VBP
cord-015684-q10sx1dm	87	13	those	those	DT
cord-015684-q10sx1dm	87	14	encoding	encode	VBG
cord-015684-q10sx1dm	87	15	proteins	protein	NNS
cord-015684-q10sx1dm	87	16	involved	involve	VBN
cord-015684-q10sx1dm	87	17	in	in	IN
cord-015684-q10sx1dm	87	18	DNA	dna	NN
cord-015684-q10sx1dm	87	19	damage	damage	NN
cord-015684-q10sx1dm	87	20	responses	response	NNS
cord-015684-q10sx1dm	87	21	,	,	,
cord-015684-q10sx1dm	87	22	mitochondrial	mitochondrial	NN
cord-015684-q10sx1dm	87	23	and	and	CC
cord-015684-q10sx1dm	87	24	proteasome	proteasome	NN
cord-015684-q10sx1dm	87	25	functions	function	NNS
cord-015684-q10sx1dm	87	26	,	,	,
cord-015684-q10sx1dm	87	27	cell	cell	NN
cord-015684-q10sx1dm	87	28	fate	fate	NN
cord-015684-q10sx1dm	87	29	determination	determination	NN
cord-015684-q10sx1dm	87	30	and	and	CC
cord-015684-q10sx1dm	87	31	synaptic	synaptic	JJ
cord-015684-q10sx1dm	87	32	vesicle	vesicle	NN
cord-015684-q10sx1dm	87	33	traffi	traffi	NNP
cord-015684-q10sx1dm	87	34	cking	cking	NNP
cord-015684-q10sx1dm	87	35	.	.	.
cord-015684-q10sx1dm	88	1	The	the	DT
cord-015684-q10sx1dm	88	2	systematic	systematic	JJ
cord-015684-q10sx1dm	88	3	transcriptome	transcriptome	NN
cord-015684-q10sx1dm	88	4	dataset	dataset	NN
cord-015684-q10sx1dm	88	5	provides	provide	VBZ
cord-015684-q10sx1dm	88	6	a	a	DT
cord-015684-q10sx1dm	88	7	window	window	NN
cord-015684-q10sx1dm	88	8	into	into	IN
cord-015684-q10sx1dm	88	9	mechanisms	mechanism	NNS
cord-015684-q10sx1dm	88	10	of	of	IN
cord-015684-q10sx1dm	88	11	neuropathogenesis	neuropathogenesis	NN
cord-015684-q10sx1dm	88	12	and	and	CC
cord-015684-q10sx1dm	88	13	CNS	CNS	NNP
cord-015684-q10sx1dm	88	14	vulnerability	vulnerability	NN
cord-015684-q10sx1dm	88	15	.	.	.
cord-015684-q10sx1dm	89	1	24	24	CD
cord-015684-q10sx1dm	90	1	With	with	IN
cord-015684-q10sx1dm	90	2	the	the	DT
cord-015684-q10sx1dm	90	3	advent	advent	NN
cord-015684-q10sx1dm	90	4	of	of	IN
cord-015684-q10sx1dm	90	5	modern	modern	JJ
cord-015684-q10sx1dm	90	6	genomic	genomic	JJ
cord-015684-q10sx1dm	90	7	technologies	technology	NNS
cord-015684-q10sx1dm	90	8	,	,	,
cord-015684-q10sx1dm	90	9	new	new	JJ
cord-015684-q10sx1dm	90	10	loci	locus	NNS
cord-015684-q10sx1dm	90	11	have	have	VBP
cord-015684-q10sx1dm	90	12	been	be	VBN
cord-015684-q10sx1dm	90	13	associated	associate	VBN
cord-015684-q10sx1dm	90	14	with	with	IN
cord-015684-q10sx1dm	90	15	different	different	JJ
cord-015684-q10sx1dm	90	16	neuropsychiatric	neuropsychiatric	JJ
cord-015684-q10sx1dm	90	17	disorders	disorder	NNS
cord-015684-q10sx1dm	90	18	,	,	,
cord-015684-q10sx1dm	90	19	and	and	CC
cord-015684-q10sx1dm	90	20	novel	novel	JJ
cord-015684-q10sx1dm	90	21	pathogenic	pathogenic	JJ
cord-015684-q10sx1dm	90	22	mechanisms	mechanism	NNS
cord-015684-q10sx1dm	90	23	have	have	VBP
cord-015684-q10sx1dm	90	24	been	be	VBN
cord-015684-q10sx1dm	90	25	postulated	postulate	VBN
cord-015684-q10sx1dm	90	26	.	.	.
cord-015684-q10sx1dm	91	1	Cryptic	cryptic	JJ
cord-015684-q10sx1dm	91	2	chromosome	chromosome	NN
cord-015684-q10sx1dm	91	3	imbalances	imbalance	NNS
cord-015684-q10sx1dm	91	4	are	be	VBP
cord-015684-q10sx1dm	91	5	increasingly	increasingly	RB
cord-015684-q10sx1dm	91	6	acknowledged	acknowledge	VBN
cord-015684-q10sx1dm	91	7	as	as	IN
cord-015684-q10sx1dm	91	8	a	a	DT
cord-015684-q10sx1dm	91	9	cause	cause	NN
cord-015684-q10sx1dm	91	10	for	for	IN
cord-015684-q10sx1dm	91	11	mental	mental	JJ
cord-015684-q10sx1dm	91	12	retardation	retardation	NN
cord-015684-q10sx1dm	91	13	and	and	CC
cord-015684-q10sx1dm	91	14	learning	learn	VBG
cord-015684-q10sx1dm	91	15	disability	disability	NN
cord-015684-q10sx1dm	91	16	.	.	.
cord-015684-q10sx1dm	92	1	With	with	IN
cord-015684-q10sx1dm	92	2	subtelomeric	subtelomeric	JJ
cord-015684-q10sx1dm	92	3	screening	screening	NN
cord-015684-q10sx1dm	92	4	,	,	,
cord-015684-q10sx1dm	92	5	nine	nine	CD
cord-015684-q10sx1dm	92	6	chromosomal	chromosomal	JJ
cord-015684-q10sx1dm	92	7	anomalies	anomaly	NNS
cord-015684-q10sx1dm	92	8	and	and	CC
cord-015684-q10sx1dm	92	9	submicroscopic	submicroscopic	JJ
cord-015684-q10sx1dm	92	10	deletions	deletion	NNS
cord-015684-q10sx1dm	92	11	of	of	IN
cord-015684-q10sx1dm	92	12	1pter	1pter	CD
cord-015684-q10sx1dm	92	13	,	,	,
cord-015684-q10sx1dm	92	14	2qter	2qter	CD
cord-015684-q10sx1dm	92	15	,	,	,
cord-015684-q10sx1dm	92	16	4pter	4pter	CD
cord-015684-q10sx1dm	92	17	,	,	,
cord-015684-q10sx1dm	92	18	5qter	5qter	CD
cord-015684-q10sx1dm	92	19	and	and	CC
cord-015684-q10sx1dm	92	20	9qter	9qter	CD
cord-015684-q10sx1dm	93	1	have	have	VBP
cord-015684-q10sx1dm	93	2	been	be	VBN
cord-015684-q10sx1dm	93	3	identifi	identifi	VBN
cord-015684-q10sx1dm	93	4	ed	ed	NN
cord-015684-q10sx1dm	93	5	in	in	IN
cord-015684-q10sx1dm	93	6	patients	patient	NNS
cord-015684-q10sx1dm	93	7	with	with	IN
cord-015684-q10sx1dm	93	8	mental	mental	JJ
cord-015684-q10sx1dm	93	9	retardation	retardation	NN
cord-015684-q10sx1dm	93	10	.	.	.
cord-015684-q10sx1dm	94	1	25	25	CD
cord-015684-q10sx1dm	94	2	Increased	increase	VBN
cord-015684-q10sx1dm	94	3	DNA	dna	NN
cord-015684-q10sx1dm	94	4	fragmentation	fragmentation	NN
cord-015684-q10sx1dm	94	5	was	be	VBD
cord-015684-q10sx1dm	94	6	observed	observe	VBN
cord-015684-q10sx1dm	94	7	in	in	IN
cord-015684-q10sx1dm	94	8	non	non	JJ
cord-015684-q10sx1dm	94	9	-	-	JJ
cord-015684-q10sx1dm	94	10	GABAergic	gabaergic	JJ
cord-015684-q10sx1dm	94	11	neurons	neuron	NNS
cord-015684-q10sx1dm	94	12	in	in	IN
cord-015684-q10sx1dm	94	13	bipolar	bipolar	JJ
cord-015684-q10sx1dm	94	14	disorder	disorder	NN
cord-015684-q10sx1dm	94	15	,	,	,
cord-015684-q10sx1dm	94	16	suggesting	suggest	VBG
cord-015684-q10sx1dm	94	17	that	that	IN
cord-015684-q10sx1dm	94	18	non	non	JJ
cord-015684-q10sx1dm	94	19	-	-	JJ
cord-015684-q10sx1dm	94	20	GABAergic	gabaergic	JJ
cord-015684-q10sx1dm	94	21	cell	cell	NN
cord-015684-q10sx1dm	94	22	may	may	MD
cord-015684-q10sx1dm	94	23	be	be	VB
cord-015684-q10sx1dm	94	24	selectively	selectively	RB
cord-015684-q10sx1dm	94	25	vulnerable	vulnerable	JJ
cord-015684-q10sx1dm	94	26	to	to	IN
cord-015684-q10sx1dm	94	27	oxidative	oxidative	JJ
cord-015684-q10sx1dm	94	28	stress	stress	NN
cord-015684-q10sx1dm	94	29	and	and	CC
cord-015684-q10sx1dm	94	30	apoptosis	apoptosis	NN
cord-015684-q10sx1dm	94	31	in	in	IN
cord-015684-q10sx1dm	94	32	patients	patient	NNS
cord-015684-q10sx1dm	94	33	with	with	IN
cord-015684-q10sx1dm	94	34	bipolar	bipolar	JJ
cord-015684-q10sx1dm	94	35	disorder	disorder	NN
cord-015684-q10sx1dm	94	36	.	.	.
cord-015684-q10sx1dm	95	1	26	26	CD
cord-015684-q10sx1dm	95	2	[	[	-LRB-
cord-015684-q10sx1dm	95	3	17	17	CD
cord-015684-q10sx1dm	95	4	]	]	-RRB-
cord-015684-q10sx1dm	95	5	[	[	-LRB-
cord-015684-q10sx1dm	95	6	18	18	CD
cord-015684-q10sx1dm	95	7	]	]	-RRB-
cord-015684-q10sx1dm	95	8	[	[	-LRB-
cord-015684-q10sx1dm	95	9	19	19	CD
cord-015684-q10sx1dm	95	10	]	]	-RRB-
cord-015684-q10sx1dm	95	11	[	[	-LRB-
cord-015684-q10sx1dm	95	12	20	20	CD
cord-015684-q10sx1dm	95	13	]	]	-RRB-
cord-015684-q10sx1dm	96	1	With	with	IN
cord-015684-q10sx1dm	96	2	laser	laser	NN
cord-015684-q10sx1dm	96	3	microdissection	microdissection	NN
cord-015684-q10sx1dm	96	4	,	,	,
cord-015684-q10sx1dm	96	5	RNA	RNA	NNP
cord-015684-q10sx1dm	96	6	amplifi	amplifi	NNP
cord-015684-q10sx1dm	96	7	cation	cation	NN
cord-015684-q10sx1dm	96	8	,	,	,
cord-015684-q10sx1dm	96	9	and	and	CC
cord-015684-q10sx1dm	96	10	array	array	NN
cord-015684-q10sx1dm	96	11	hybridization	hybridization	NN
cord-015684-q10sx1dm	96	12	,	,	,
cord-015684-q10sx1dm	97	1	expression	expression	NN
cord-015684-q10sx1dm	97	2	of	of	IN
cord-015684-q10sx1dm	97	3	more	more	JJR
cord-015684-q10sx1dm	97	4	than	than	IN
cord-015684-q10sx1dm	97	5	1,000	1,000	CD
cord-015684-q10sx1dm	97	6	genes	gene	NNS
cord-015684-q10sx1dm	97	7	was	be	VBD
cord-015684-q10sx1dm	97	8	detected	detect	VBN
cord-015684-q10sx1dm	97	9	in	in	IN
cord-015684-q10sx1dm	97	10	CA1	CA1	NNP
cord-015684-q10sx1dm	97	11	and	and	CC
cord-015684-q10sx1dm	97	12	CA3	CA3	NNP
cord-015684-q10sx1dm	97	13	hippocampal	hippocampal	JJ
cord-015684-q10sx1dm	97	14	neurons	neuron	NNS
cord-015684-q10sx1dm	97	15	under	under	IN
cord-015684-q10sx1dm	97	16	normoxic	normoxic	JJ
cord-015684-q10sx1dm	97	17	conditions	condition	NNS
cord-015684-q10sx1dm	97	18	.	.	.
cord-015684-q10sx1dm	98	1	The	the	DT
cord-015684-q10sx1dm	98	2	comparison	comparison	NN
cord-015684-q10sx1dm	98	3	of	of	IN
cord-015684-q10sx1dm	98	4	each	each	DT
cord-015684-q10sx1dm	98	5	region	region	NN
cord-015684-q10sx1dm	98	6	under	under	IN
cord-015684-q10sx1dm	98	7	normoxic	normoxic	JJ
cord-015684-q10sx1dm	98	8	and	and	CC
cord-015684-q10sx1dm	98	9	ischemic	ischemic	JJ
cord-015684-q10sx1dm	98	10	conditions	condition	NNS
cord-015684-q10sx1dm	98	11	revealed	reveal	VBD
cord-015684-q10sx1dm	98	12	more	more	JJR
cord-015684-q10sx1dm	98	13	than	than	IN
cord-015684-q10sx1dm	98	14	5,000	5,000	CD
cord-015684-q10sx1dm	98	15	ischemia	ischemia	NN
cord-015684-q10sx1dm	98	16	-	-	HYPH
cord-015684-q10sx1dm	98	17	regulated	regulate	VBN
cord-015684-q10sx1dm	98	18	genes	gene	NNS
cord-015684-q10sx1dm	98	19	for	for	IN
cord-015684-q10sx1dm	98	20	each	each	DT
cord-015684-q10sx1dm	98	21	individual	individual	JJ
cord-015684-q10sx1dm	98	22	cell	cell	NN
cord-015684-q10sx1dm	98	23	type	type	NN
cord-015684-q10sx1dm	98	24	.	.	.
cord-015684-q10sx1dm	99	1	27	27	CD
cord-015684-q10sx1dm	99	2	Microarray	Microarray	NNP
cord-015684-q10sx1dm	99	3	technology	technology	NN
cord-015684-q10sx1dm	99	4	has	have	VBZ
cord-015684-q10sx1dm	99	5	helped	help	VBN
cord-015684-q10sx1dm	99	6	to	to	TO
cord-015684-q10sx1dm	99	7	elucidate	elucidate	VB
cord-015684-q10sx1dm	99	8	gene	gene	NN
cord-015684-q10sx1dm	99	9	expression	expression	NN
cord-015684-q10sx1dm	99	10	profi	profi	NNP
cord-015684-q10sx1dm	99	11	les	les	NNP
cord-015684-q10sx1dm	99	12	and	and	CC
cord-015684-q10sx1dm	99	13	potential	potential	JJ
cord-015684-q10sx1dm	99	14	pathogenic	pathogenic	JJ
cord-015684-q10sx1dm	99	15	mechanisms	mechanism	NNS
cord-015684-q10sx1dm	99	16	in	in	IN
cord-015684-q10sx1dm	99	17	many	many	JJ
cord-015684-q10sx1dm	99	18	other	other	JJ
cord-015684-q10sx1dm	99	19	CNS	CNS	NNP
cord-015684-q10sx1dm	99	20	disorders	disorder	NNS
cord-015684-q10sx1dm	99	21	including	include	VBG
cord-015684-q10sx1dm	99	22	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	99	23	and	and	CC
cord-015684-q10sx1dm	99	24	bipolar	bipolar	JJ
cord-015684-q10sx1dm	99	25	disorder	disorder	NN
cord-015684-q10sx1dm	99	26	,	,	,
cord-015684-q10sx1dm	99	27	[	[	-LRB-
cord-015684-q10sx1dm	99	28	28	28	CD
cord-015684-q10sx1dm	99	29	]	]	-RRB-
cord-015684-q10sx1dm	99	30	[	[	-LRB-
cord-015684-q10sx1dm	99	31	29	29	CD
cord-015684-q10sx1dm	99	32	]	]	-RRB-
cord-015684-q10sx1dm	99	33	[	[	-LRB-
cord-015684-q10sx1dm	99	34	30	30	CD
cord-015684-q10sx1dm	99	35	]	]	-RRB-
cord-015684-q10sx1dm	99	36	speech	speech	NN
cord-015684-q10sx1dm	99	37	and	and	CC
cord-015684-q10sx1dm	99	38	language	language	NN
cord-015684-q10sx1dm	99	39	disorders	disorder	NNS
cord-015684-q10sx1dm	99	40	,	,	,
cord-015684-q10sx1dm	99	41	31	31	CD
cord-015684-q10sx1dm	99	42	Parkinson	Parkinson	NNP
cord-015684-q10sx1dm	99	43	's	's	POS
cord-015684-q10sx1dm	99	44	disease	disease	NN
cord-015684-q10sx1dm	99	45	,	,	,
cord-015684-q10sx1dm	99	46	32	32	CD
cord-015684-q10sx1dm	99	47	,	,	,
cord-015684-q10sx1dm	99	48	33	33	CD
cord-015684-q10sx1dm	99	49	Huntington	Huntington	NNP
cord-015684-q10sx1dm	99	50	's	's	POS
cord-015684-q10sx1dm	99	51	disease	disease	NN
cord-015684-q10sx1dm	99	52	,	,	,
cord-015684-q10sx1dm	99	53	34	34	CD
cord-015684-q10sx1dm	99	54	prion	prion	NN
cord-015684-q10sx1dm	99	55	disease	disease	NN
cord-015684-q10sx1dm	99	56	,	,	,
cord-015684-q10sx1dm	99	57	35	35	CD
cord-015684-q10sx1dm	99	58	drug	drug	NN
cord-015684-q10sx1dm	99	59	addiction	addiction	NN
cord-015684-q10sx1dm	99	60	,	,	,
cord-015684-q10sx1dm	99	61	36,37	36,37	CD
cord-015684-q10sx1dm	99	62	alcoholism	alcoholism	NN
cord-015684-q10sx1dm	99	63	,	,	,
cord-015684-q10sx1dm	99	64	38	38	CD
cord-015684-q10sx1dm	99	65	brain	brain	NN
cord-015684-q10sx1dm	99	66	trauma	trauma	NN
cord-015684-q10sx1dm	99	67	,	,	,
cord-015684-q10sx1dm	99	68	39	39	CD
cord-015684-q10sx1dm	99	69	epilepsy	epilepsy	NN
cord-015684-q10sx1dm	99	70	,	,	,
cord-015684-q10sx1dm	99	71	[	[	-LRB-
cord-015684-q10sx1dm	99	72	40	40	CD
cord-015684-q10sx1dm	99	73	]	]	-RRB-
cord-015684-q10sx1dm	99	74	[	[	-LRB-
cord-015684-q10sx1dm	99	75	41	41	CD
cord-015684-q10sx1dm	99	76	]	]	-RRB-
cord-015684-q10sx1dm	99	77	[	[	-LRB-
cord-015684-q10sx1dm	99	78	42	42	CD
cord-015684-q10sx1dm	99	79	]	]	-RRB-
cord-015684-q10sx1dm	99	80	Cockayne	Cockayne	NNP
cord-015684-q10sx1dm	99	81	syndrome	syndrome	NN
cord-015684-q10sx1dm	99	82	,	,	,
cord-015684-q10sx1dm	99	83	43	43	CD
cord-015684-q10sx1dm	99	84	Rett	Rett	NNP
cord-015684-q10sx1dm	99	85	syndrome	syndrome	NN
cord-015684-q10sx1dm	99	86	,	,	,
cord-015684-q10sx1dm	99	87	44	44	CD
cord-015684-q10sx1dm	99	88	Friedreich	Friedreich	NNP
cord-015684-q10sx1dm	99	89	ataxia	ataxia	NN
cord-015684-q10sx1dm	99	90	,	,	,
cord-015684-q10sx1dm	99	91	45	45	CD
cord-015684-q10sx1dm	99	92	neuronal	neuronal	JJ
cord-015684-q10sx1dm	99	93	ceroid	ceroid	JJ
cord-015684-q10sx1dm	99	94	lipofuscinosis	lipofuscinosis	NN
cord-015684-q10sx1dm	99	95	,	,	,
cord-015684-q10sx1dm	99	96	46	46	CD
cord-015684-q10sx1dm	99	97	multiple	multiple	JJ
cord-015684-q10sx1dm	99	98	sclerosis	sclerosis	NN
cord-015684-q10sx1dm	99	99	,	,	,
cord-015684-q10sx1dm	99	100	47	47	CD
cord-015684-q10sx1dm	99	101	amyotrophic	amyotrophic	JJ
cord-015684-q10sx1dm	99	102	lateral	lateral	JJ
cord-015684-q10sx1dm	99	103	esclerosis	esclerosis	NN
cord-015684-q10sx1dm	99	104	,	,	,
cord-015684-q10sx1dm	99	105	48	48	CD
cord-015684-q10sx1dm	99	106	acute	acute	JJ
cord-015684-q10sx1dm	99	107	pneumococcal	pneumococcal	JJ
cord-015684-q10sx1dm	99	108	meningitis	meningitis	NN
cord-015684-q10sx1dm	99	109	,	,	,
cord-015684-q10sx1dm	99	110	49	49	CD
cord-015684-q10sx1dm	99	111	and	and	CC
cord-015684-q10sx1dm	99	112	the	the	DT
cord-015684-q10sx1dm	99	113	role	role	NN
cord-015684-q10sx1dm	99	114	of	of	IN
cord-015684-q10sx1dm	99	115	lipids	lipid	NNS
cord-015684-q10sx1dm	99	116	in	in	IN
cord-015684-q10sx1dm	99	117	brain	brain	NN
cord-015684-q10sx1dm	99	118	injury	injury	NN
cord-015684-q10sx1dm	99	119	,	,	,
cord-015684-q10sx1dm	99	120	psychiatric	psychiatric	JJ
cord-015684-q10sx1dm	99	121	disorders	disorder	NNS
cord-015684-q10sx1dm	99	122	,	,	,
cord-015684-q10sx1dm	99	123	and	and	CC
cord-015684-q10sx1dm	99	124	neurodegenerative	neurodegenerative	JJ
cord-015684-q10sx1dm	99	125	diseases	disease	NNS
cord-015684-q10sx1dm	99	126	.	.	.
cord-015684-q10sx1dm	100	1	[	[	-LRB-
cord-015684-q10sx1dm	100	2	50	50	CD
cord-015684-q10sx1dm	100	3	]	]	-RRB-
cord-015684-q10sx1dm	100	4	[	[	-LRB-
cord-015684-q10sx1dm	100	5	51	51	CD
cord-015684-q10sx1dm	100	6	]	]	-RRB-
cord-015684-q10sx1dm	101	1	[	[	-LRB-
cord-015684-q10sx1dm	101	2	52	52	CD
cord-015684-q10sx1dm	101	3	]	]	-RRB-
cord-015684-q10sx1dm	101	4	Interactions	Interactions	NNPS
cord-015684-q10sx1dm	101	5	between	between	IN
cord-015684-q10sx1dm	101	6	genomic	genomic	JJ
cord-015684-q10sx1dm	101	7	factors	factor	NNS
cord-015684-q10sx1dm	101	8	and	and	CC
cord-015684-q10sx1dm	101	9	environmental	environmental	JJ
cord-015684-q10sx1dm	101	10	factors	factor	NNS
cord-015684-q10sx1dm	101	11	have	have	VBP
cord-015684-q10sx1dm	101	12	been	be	VBN
cord-015684-q10sx1dm	101	13	proposed	propose	VBN
cord-015684-q10sx1dm	101	14	as	as	IN
cord-015684-q10sx1dm	101	15	important	important	JJ
cord-015684-q10sx1dm	101	16	contributors	contributor	NNS
cord-015684-q10sx1dm	101	17	for	for	IN
cord-015684-q10sx1dm	101	18	brain	brain	NN
cord-015684-q10sx1dm	101	19	neuropathology	neuropathology	NN
cord-015684-q10sx1dm	101	20	.	.	.
cord-015684-q10sx1dm	102	1	In	in	IN
cord-015684-q10sx1dm	102	2	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	102	3	,	,	,
cord-015684-q10sx1dm	102	4	neurodevelopmental	neurodevelopmental	JJ
cord-015684-q10sx1dm	102	5	disturbances	disturbance	NNS
cord-015684-q10sx1dm	102	6	,	,	,
cord-015684-q10sx1dm	102	7	neurotoxins	neurotoxin	NNS
cord-015684-q10sx1dm	102	8	and	and	CC
cord-015684-q10sx1dm	102	9	perinatal	perinatal	JJ
cord-015684-q10sx1dm	102	10	infections	infection	NNS
cord-015684-q10sx1dm	102	11	,	,	,
cord-015684-q10sx1dm	102	12	myelin	myelin	NN
cord-015684-q10sx1dm	102	13	-	-	HYPH
cord-015684-q10sx1dm	102	14	and	and	CC
cord-015684-q10sx1dm	102	15	olygodendrocytes	olygodendrocyte	NNS
cord-015684-q10sx1dm	102	16	abnormalities	abnormality	NNS
cord-015684-q10sx1dm	102	17	and	and	CC
cord-015684-q10sx1dm	102	18	synaptic	synaptic	JJ
cord-015684-q10sx1dm	102	19	dysfunctions	dysfunction	NNS
cord-015684-q10sx1dm	102	20	have	have	VBP
cord-015684-q10sx1dm	102	21	been	be	VBN
cord-015684-q10sx1dm	102	22	suggested	suggest	VBN
cord-015684-q10sx1dm	102	23	as	as	IN
cord-015684-q10sx1dm	102	24	pathophysiological	pathophysiological	JJ
cord-015684-q10sx1dm	102	25	factors	factor	NNS
cord-015684-q10sx1dm	102	26	.	.	.
cord-015684-q10sx1dm	103	1	Individual	individual	JJ
cord-015684-q10sx1dm	103	2	genotoxicants	genotoxicant	NNS
cord-015684-q10sx1dm	103	3	can	can	MD
cord-015684-q10sx1dm	103	4	induce	induce	VB
cord-015684-q10sx1dm	103	5	distinct	distinct	JJ
cord-015684-q10sx1dm	103	6	gene	gene	NN
cord-015684-q10sx1dm	103	7	expression	expression	NN
cord-015684-q10sx1dm	103	8	signatures	signature	NNS
cord-015684-q10sx1dm	103	9	.	.	.
cord-015684-q10sx1dm	104	1	Exposure	exposure	NN
cord-015684-q10sx1dm	104	2	of	of	IN
cord-015684-q10sx1dm	104	3	the	the	DT
cord-015684-q10sx1dm	104	4	brain	brain	NN
cord-015684-q10sx1dm	104	5	to	to	IN
cord-015684-q10sx1dm	104	6	environmental	environmental	JJ
cord-015684-q10sx1dm	104	7	agents	agent	NNS
cord-015684-q10sx1dm	104	8	during	during	IN
cord-015684-q10sx1dm	104	9	critical	critical	JJ
cord-015684-q10sx1dm	104	10	periods	period	NNS
cord-015684-q10sx1dm	104	11	of	of	IN
cord-015684-q10sx1dm	104	12	neuronal	neuronal	JJ
cord-015684-q10sx1dm	104	13	development	development	NN
cord-015684-q10sx1dm	104	14	can	can	MD
cord-015684-q10sx1dm	104	15	alter	alter	VB
cord-015684-q10sx1dm	104	16	neuronal	neuronal	JJ
cord-015684-q10sx1dm	104	17	viability	viability	NN
cord-015684-q10sx1dm	104	18	and	and	CC
cord-015684-q10sx1dm	104	19	differentiation	differentiation	NN
cord-015684-q10sx1dm	104	20	,	,	,
cord-015684-q10sx1dm	104	21	global	global	JJ
cord-015684-q10sx1dm	104	22	gene	gene	NN
cord-015684-q10sx1dm	104	23	expression	expression	NN
cord-015684-q10sx1dm	104	24	,	,	,
cord-015684-q10sx1dm	104	25	stress	stress	NN
cord-015684-q10sx1dm	104	26	and	and	CC
cord-015684-q10sx1dm	104	27	immune	immune	JJ
cord-015684-q10sx1dm	104	28	response	response	NN
cord-015684-q10sx1dm	104	29	,	,	,
cord-015684-q10sx1dm	104	30	and	and	CC
cord-015684-q10sx1dm	104	31	signal	signal	NN
cord-015684-q10sx1dm	104	32	transduction	transduction	NN
cord-015684-q10sx1dm	104	33	.	.	.
cord-015684-q10sx1dm	105	1	53	53	CD
cord-015684-q10sx1dm	106	1	The	the	DT
cord-015684-q10sx1dm	106	2	binomial	binomial	JJ
cord-015684-q10sx1dm	106	3	genome	genome	NN
cord-015684-q10sx1dm	106	4	-	-	HYPH
cord-015684-q10sx1dm	106	5	neurotoxicants	neurotoxicants	NN
cord-015684-q10sx1dm	106	6	effect	effect	NN
cord-015684-q10sx1dm	106	7	can	can	MD
cord-015684-q10sx1dm	106	8	be	be	VB
cord-015684-q10sx1dm	106	9	documented	document	VBN
cord-015684-q10sx1dm	106	10	in	in	IN
cord-015684-q10sx1dm	106	11	cases	case	NNS
cord-015684-q10sx1dm	106	12	of	of	IN
cord-015684-q10sx1dm	106	13	drug	drug	NN
cord-015684-q10sx1dm	106	14	abuse	abuse	NN
cord-015684-q10sx1dm	106	15	or	or	CC
cord-015684-q10sx1dm	106	16	alcohol	alcohol	NN
cord-015684-q10sx1dm	106	17	dependence	dependence	NN
cord-015684-q10sx1dm	106	18	.	.	.
cord-015684-q10sx1dm	107	1	Functional	functional	JJ
cord-015684-q10sx1dm	107	2	gene	gene	NN
cord-015684-q10sx1dm	107	3	expression	expression	NN
cord-015684-q10sx1dm	107	4	differences	difference	NNS
cord-015684-q10sx1dm	107	5	between	between	IN
cord-015684-q10sx1dm	107	6	inbred	inbred	JJ
cord-015684-q10sx1dm	107	7	alcohol	alcohol	NN
cord-015684-q10sx1dm	107	8	-	-	:
cord-015684-q10sx1dm	107	9	preferring	preferring	NN
cord-015684-q10sx1dm	107	10	and	and	CC
cord-015684-q10sx1dm	107	11	nonpreferring	nonpreferre	VBG
cord-015684-q10sx1dm	107	12	rats	rat	NNS
cord-015684-q10sx1dm	107	13	suggest	suggest	VBP
cord-015684-q10sx1dm	107	14	the	the	DT
cord-015684-q10sx1dm	107	15	presence	presence	NN
cord-015684-q10sx1dm	107	16	of	of	IN
cord-015684-q10sx1dm	107	17	powerful	powerful	JJ
cord-015684-q10sx1dm	107	18	genomic	genomic	JJ
cord-015684-q10sx1dm	107	19	infl	infl	NN
cord-015684-q10sx1dm	107	20	uences	uence	NNS
cord-015684-q10sx1dm	107	21	on	on	IN
cord-015684-q10sx1dm	107	22	alcohol	alcohol	NN
cord-015684-q10sx1dm	107	23	dependence	dependence	NN
cord-015684-q10sx1dm	107	24	.	.	.
cord-015684-q10sx1dm	108	1	54	54	CD
cord-015684-q10sx1dm	108	2	Alcohol	alcohol	NN
cord-015684-q10sx1dm	108	3	dependence	dependence	NN
cord-015684-q10sx1dm	108	4	and	and	CC
cord-015684-q10sx1dm	108	5	associated	associate	VBN
cord-015684-q10sx1dm	108	6	cognitive	cognitive	JJ
cord-015684-q10sx1dm	108	7	impairment	impairment	NN
cord-015684-q10sx1dm	108	8	may	may	MD
cord-015684-q10sx1dm	108	9	result	result	VB
cord-015684-q10sx1dm	108	10	from	from	IN
cord-015684-q10sx1dm	108	11	neuroadaptations	neuroadaptation	NNS
cord-015684-q10sx1dm	108	12	to	to	IN
cord-015684-q10sx1dm	108	13	chronic	chronic	JJ
cord-015684-q10sx1dm	108	14	alcohol	alcohol	NN
cord-015684-q10sx1dm	108	15	consumption	consumption	NN
cord-015684-q10sx1dm	108	16	involving	involve	VBG
cord-015684-q10sx1dm	108	17	changes	change	NNS
cord-015684-q10sx1dm	108	18	in	in	IN
cord-015684-q10sx1dm	108	19	expression	expression	NN
cord-015684-q10sx1dm	108	20	of	of	IN
cord-015684-q10sx1dm	108	21	multiple	multiple	JJ
cord-015684-q10sx1dm	108	22	genes	gene	NNS
cord-015684-q10sx1dm	108	23	.	.	.
cord-015684-q10sx1dm	109	1	It	-PRON-	PRP
cord-015684-q10sx1dm	109	2	has	have	VBZ
cord-015684-q10sx1dm	109	3	been	be	VBN
cord-015684-q10sx1dm	109	4	suggested	suggest	VBN
cord-015684-q10sx1dm	109	5	that	that	IN
cord-015684-q10sx1dm	109	6	cycles	cycle	NNS
cord-015684-q10sx1dm	109	7	of	of	IN
cord-015684-q10sx1dm	109	8	alcohol	alcohol	NN
cord-015684-q10sx1dm	109	9	intoxication	intoxication	NN
cord-015684-q10sx1dm	109	10	/	/	SYM
cord-015684-q10sx1dm	109	11	withdrawal	withdrawal	NN
cord-015684-q10sx1dm	109	12	,	,	,
cord-015684-q10sx1dm	109	13	which	which	WDT
cord-015684-q10sx1dm	109	14	may	may	MD
cord-015684-q10sx1dm	109	15	initially	initially	RB
cord-015684-q10sx1dm	109	16	activate	activate	VB
cord-015684-q10sx1dm	109	17	nuclear	nuclear	JJ
cord-015684-q10sx1dm	109	18	factor	factor	NN
cord-015684-q10sx1dm	109	19	-	-	HYPH
cord-015684-q10sx1dm	109	20	kappa	kappa	NN
cord-015684-q10sx1dm	109	21	B	b	NN
cord-015684-q10sx1dm	109	22	(	(	-LRB-
cord-015684-q10sx1dm	109	23	NF	NF	NNP
cord-015684-q10sx1dm	109	24	-	-	HYPH
cord-015684-q10sx1dm	109	25	κB	κB	NNP
cord-015684-q10sx1dm	109	26	)	)	-RRB-
cord-015684-q10sx1dm	109	27	,	,	,
cord-015684-q10sx1dm	109	28	when	when	WRB
cord-015684-q10sx1dm	109	29	repeated	repeat	VBN
cord-015684-q10sx1dm	109	30	over	over	IN
cord-015684-q10sx1dm	109	31	years	year	NNS
cord-015684-q10sx1dm	109	32	downregulate	downregulate	VB
cord-015684-q10sx1dm	109	33	p65	p65	CD
cord-015684-q10sx1dm	109	34	(	(	-LRB-
cord-015684-q10sx1dm	109	35	RELA	RELA	NNP
cord-015684-q10sx1dm	109	36	)	)	-RRB-
cord-015684-q10sx1dm	109	37	mRNA	mrna	NN
cord-015684-q10sx1dm	109	38	expression	expression	NN
cord-015684-q10sx1dm	109	39	and	and	CC
cord-015684-q10sx1dm	109	40	NF	nf	NN
cord-015684-q10sx1dm	109	41	-	-	HYPH
cord-015684-q10sx1dm	109	42	κB	κB	NNP
cord-015684-q10sx1dm	109	43	and	and	CC
cord-015684-q10sx1dm	109	44	p50	p50	NN
cord-015684-q10sx1dm	109	45	homodimer	homodimer	JJ
cord-015684-q10sx1dm	109	46	DNA	dna	NN
cord-015684-q10sx1dm	109	47	-	-	HYPH
cord-015684-q10sx1dm	109	48	binding	binding	NN
cord-015684-q10sx1dm	109	49	.	.	.
cord-015684-q10sx1dm	110	1	Downregulation	Downregulation	NNP
cord-015684-q10sx1dm	110	2	of	of	IN
cord-015684-q10sx1dm	110	3	the	the	DT
cord-015684-q10sx1dm	110	4	dominant	dominant	JJ
cord-015684-q10sx1dm	110	5	p50	p50	NN
cord-015684-q10sx1dm	110	6	homodimer	homodimer	NN
cord-015684-q10sx1dm	110	7	,	,	,
cord-015684-q10sx1dm	110	8	a	a	DT
cord-015684-q10sx1dm	110	9	potent	potent	JJ
cord-015684-q10sx1dm	110	10	inhibitor	inhibitor	NN
cord-015684-q10sx1dm	110	11	of	of	IN
cord-015684-q10sx1dm	110	12	gene	gene	NN
cord-015684-q10sx1dm	110	13	transcription	transcription	NN
cord-015684-q10sx1dm	110	14	apparently	apparently	RB
cord-015684-q10sx1dm	110	15	results	result	VBZ
cord-015684-q10sx1dm	110	16	in	in	IN
cord-015684-q10sx1dm	110	17	depression	depression	NN
cord-015684-q10sx1dm	110	18	of	of	IN
cord-015684-q10sx1dm	110	19	κB	κb	CD
cord-015684-q10sx1dm	110	20	regulated	regulate	VBN
cord-015684-q10sx1dm	110	21	genes	gene	NNS
cord-015684-q10sx1dm	110	22	.	.	.
cord-015684-q10sx1dm	111	1	Alterations	alteration	NNS
cord-015684-q10sx1dm	111	2	in	in	IN
cord-015684-q10sx1dm	111	3	expression	expression	NN
cord-015684-q10sx1dm	111	4	of	of	IN
cord-015684-q10sx1dm	111	5	p50	p50	NN
cord-015684-q10sx1dm	111	6	homodimer	homodimer	NNP
cord-015684-q10sx1dm	111	7	/	/	SYM
cord-015684-q10sx1dm	111	8	NF	NF	NNP
cord-015684-q10sx1dm	111	9	-	-	HYPH
cord-015684-q10sx1dm	111	10	κB	κb	CD
cord-015684-q10sx1dm	111	11	regulated	regulate	VBN
cord-015684-q10sx1dm	111	12	genes	gene	NNS
cord-015684-q10sx1dm	111	13	may	may	MD
cord-015684-q10sx1dm	111	14	contribute	contribute	VB
cord-015684-q10sx1dm	111	15	to	to	IN
cord-015684-q10sx1dm	111	16	neuroplastic	neuroplastic	JJ
cord-015684-q10sx1dm	111	17	adaptation	adaptation	NN
cord-015684-q10sx1dm	111	18	underlying	underlie	VBG
cord-015684-q10sx1dm	111	19	alcoholism	alcoholism	NN
cord-015684-q10sx1dm	111	20	.	.	.
cord-015684-q10sx1dm	112	1	55	55	CD
cord-015684-q10sx1dm	112	2	Gene	gene	NN
cord-015684-q10sx1dm	112	3	expression	expression	NN
cord-015684-q10sx1dm	112	4	profi	profi	NNP
cord-015684-q10sx1dm	112	5	ling	ling	NNP
cord-015684-q10sx1dm	112	6	of	of	IN
cord-015684-q10sx1dm	112	7	the	the	DT
cord-015684-q10sx1dm	112	8	nucleus	nucleus	NN
cord-015684-q10sx1dm	112	9	accumbens	accumben	NNS
cord-015684-q10sx1dm	112	10	of	of	IN
cord-015684-q10sx1dm	112	11	cocaine	cocaine	NN
cord-015684-q10sx1dm	112	12	abusers	abuser	NNS
cord-015684-q10sx1dm	112	13	suggests	suggest	VBZ
cord-015684-q10sx1dm	112	14	a	a	DT
cord-015684-q10sx1dm	112	15	dysregulation	dysregulation	NN
cord-015684-q10sx1dm	112	16	of	of	IN
cord-015684-q10sx1dm	112	17	myelin	myelin	NN
cord-015684-q10sx1dm	112	18	.	.	.
cord-015684-q10sx1dm	113	1	56	56	CD
cord-015684-q10sx1dm	113	2	Humans	human	NNS
cord-015684-q10sx1dm	113	3	who	who	WP
cord-015684-q10sx1dm	113	4	abused	abuse	VBD
cord-015684-q10sx1dm	113	5	cocaine	cocaine	NN
cord-015684-q10sx1dm	113	6	,	,	,
cord-015684-q10sx1dm	113	7	cannabis	cannabis	NN
cord-015684-q10sx1dm	113	8	and/or	and/or	CC
cord-015684-q10sx1dm	113	9	phencyclidine	phencyclidine	NN
cord-015684-q10sx1dm	113	10	share	share	VBP
cord-015684-q10sx1dm	113	11	a	a	DT
cord-015684-q10sx1dm	113	12	decrease	decrease	NN
cord-015684-q10sx1dm	113	13	in	in	IN
cord-015684-q10sx1dm	113	14	transcription	transcription	NN
cord-015684-q10sx1dm	113	15	of	of	IN
cord-015684-q10sx1dm	113	16	calmodulin	calmodulin	NN
cord-015684-q10sx1dm	113	17	-	-	HYPH
cord-015684-q10sx1dm	113	18	related	relate	VBN
cord-015684-q10sx1dm	113	19	genes	gene	NNS
cord-015684-q10sx1dm	113	20	and	and	CC
cord-015684-q10sx1dm	113	21	increased	increase	VBD
cord-015684-q10sx1dm	113	22	transcription	transcription	NN
cord-015684-q10sx1dm	113	23	related	relate	VBN
cord-015684-q10sx1dm	113	24	to	to	IN
cord-015684-q10sx1dm	113	25	lipid	lipid	NN
cord-015684-q10sx1dm	113	26	/	/	SYM
cord-015684-q10sx1dm	113	27	cholesterol	cholesterol	NN
cord-015684-q10sx1dm	113	28	and	and	CC
cord-015684-q10sx1dm	113	29	Golgi	Golgi	NNP
cord-015684-q10sx1dm	113	30	/	/	SYM
cord-015684-q10sx1dm	113	31	ER	ER	NNP
cord-015684-q10sx1dm	113	32	function	function	NN
cord-015684-q10sx1dm	113	33	.	.	.
cord-015684-q10sx1dm	114	1	57	57	CD
cord-015684-q10sx1dm	115	1	Another	another	DT
cord-015684-q10sx1dm	115	2	important	important	JJ
cord-015684-q10sx1dm	115	3	issue	issue	NN
cord-015684-q10sx1dm	115	4	in	in	IN
cord-015684-q10sx1dm	115	5	the	the	DT
cord-015684-q10sx1dm	115	6	pathogenesis	pathogenesis	NN
cord-015684-q10sx1dm	115	7	and	and	CC
cord-015684-q10sx1dm	115	8	therapeutics	therapeutic	NNS
cord-015684-q10sx1dm	115	9	of	of	IN
cord-015684-q10sx1dm	115	10	CNS	CNS	NNP
cord-015684-q10sx1dm	115	11	disorders	disorder	NNS
cord-015684-q10sx1dm	115	12	is	be	VBZ
cord-015684-q10sx1dm	115	13	the	the	DT
cord-015684-q10sx1dm	115	14	role	role	NN
cord-015684-q10sx1dm	115	15	of	of	IN
cord-015684-q10sx1dm	115	16	microR	microR	NNP
cord-015684-q10sx1dm	115	17	-	-	HYPH
cord-015684-q10sx1dm	115	18	NAs	NAs	NNPS
cord-015684-q10sx1dm	115	19	(	(	-LRB-
cord-015684-q10sx1dm	115	20	miRNAs	miRNAs	NNP
cord-015684-q10sx1dm	115	21	)	)	-RRB-
cord-015684-q10sx1dm	115	22	.	.	.
cord-015684-q10sx1dm	116	1	miRNAs	miRNAs	NNP
cord-015684-q10sx1dm	116	2	are	be	VBP
cord-015684-q10sx1dm	116	3	small	small	JJ
cord-015684-q10sx1dm	116	4	(	(	-LRB-
cord-015684-q10sx1dm	116	5	22	22	CD
cord-015684-q10sx1dm	116	6	nucleotide	nucleotide	NN
cord-015684-q10sx1dm	116	7	)	)	-RRB-
cord-015684-q10sx1dm	116	8	,	,	,
cord-015684-q10sx1dm	116	9	endogenous	endogenous	JJ
cord-015684-q10sx1dm	116	10	noncoding	noncoding	JJ
cord-015684-q10sx1dm	116	11	RNA	RNA	NNP
cord-015684-q10sx1dm	116	12	molecules	molecule	NNS
cord-015684-q10sx1dm	116	13	that	that	WDT
cord-015684-q10sx1dm	116	14	posttranscriptionally	posttranscriptionally	RB
cord-015684-q10sx1dm	116	15	regulate	regulate	VBP
cord-015684-q10sx1dm	116	16	expression	expression	NN
cord-015684-q10sx1dm	116	17	of	of	IN
cord-015684-q10sx1dm	116	18	protein	protein	NN
cord-015684-q10sx1dm	116	19	-	-	HYPH
cord-015684-q10sx1dm	116	20	coding	code	VBG
cord-015684-q10sx1dm	116	21	genes	gene	NNS
cord-015684-q10sx1dm	116	22	.	.	.
cord-015684-q10sx1dm	117	1	Computational	computational	JJ
cord-015684-q10sx1dm	117	2	predictions	prediction	NNS
cord-015684-q10sx1dm	117	3	estimate	estimate	VBP
cord-015684-q10sx1dm	117	4	that	that	IN
cord-015684-q10sx1dm	117	5	the	the	DT
cord-015684-q10sx1dm	117	6	vertebrate	vertebrate	JJ
cord-015684-q10sx1dm	117	7	genomes	genome	NNS
cord-015684-q10sx1dm	117	8	may	may	MD
cord-015684-q10sx1dm	117	9	contain	contain	VB
cord-015684-q10sx1dm	117	10	up	up	IN
cord-015684-q10sx1dm	117	11	to	to	IN
cord-015684-q10sx1dm	117	12	1,000	1,000	CD
cord-015684-q10sx1dm	117	13	miRNA	miRNA	NNP
cord-015684-q10sx1dm	117	14	genes	gene	NNS
cord-015684-q10sx1dm	117	15	.	.	.
cord-015684-q10sx1dm	118	1	miRNAs	miRNAs	NNP
cord-015684-q10sx1dm	118	2	are	be	VBP
cord-015684-q10sx1dm	118	3	generated	generate	VBN
cord-015684-q10sx1dm	118	4	from	from	IN
cord-015684-q10sx1dm	118	5	long	long	JJ
cord-015684-q10sx1dm	118	6	primary	primary	JJ
cord-015684-q10sx1dm	118	7	transcripts	transcript	NNS
cord-015684-q10sx1dm	118	8	that	that	WDT
cord-015684-q10sx1dm	118	9	are	be	VBP
cord-015684-q10sx1dm	118	10	processed	process	VBN
cord-015684-q10sx1dm	118	11	in	in	IN
cord-015684-q10sx1dm	118	12	multiple	multiple	JJ
cord-015684-q10sx1dm	118	13	steps	step	NNS
cord-015684-q10sx1dm	118	14	to	to	TO
cord-015684-q10sx1dm	118	15	cytoplasmic	cytoplasmic	VB
cord-015684-q10sx1dm	118	16	22	22	CD
cord-015684-q10sx1dm	118	17	nucleotide	nucleotide	NN
cord-015684-q10sx1dm	118	18	mature	mature	NN
cord-015684-q10sx1dm	118	19	miRNAs	miRNAs	NNP
cord-015684-q10sx1dm	118	20	.	.	.
cord-015684-q10sx1dm	119	1	The	the	DT
cord-015684-q10sx1dm	119	2	mature	mature	JJ
cord-015684-q10sx1dm	119	3	miRNA	miRNA	NNP
cord-015684-q10sx1dm	119	4	is	be	VBZ
cord-015684-q10sx1dm	119	5	incorporated	incorporate	VBN
cord-015684-q10sx1dm	119	6	into	into	IN
cord-015684-q10sx1dm	119	7	the	the	DT
cord-015684-q10sx1dm	119	8	miRNA	miRNA	NNP
cord-015684-q10sx1dm	119	9	-	-	HYPH
cord-015684-q10sx1dm	119	10	induced	induce	VBN
cord-015684-q10sx1dm	119	11	silencing	silence	VBG
cord-015684-q10sx1dm	119	12	complex	complex	NN
cord-015684-q10sx1dm	119	13	(	(	-LRB-
cord-015684-q10sx1dm	119	14	miRISC	miRISC	NNP
cord-015684-q10sx1dm	119	15	)	)	-RRB-
cord-015684-q10sx1dm	119	16	,	,	,
cord-015684-q10sx1dm	119	17	which	which	WDT
cord-015684-q10sx1dm	119	18	guides	guide	VBZ
cord-015684-q10sx1dm	119	19	it	-PRON-	PRP
cord-015684-q10sx1dm	119	20	to	to	TO
cord-015684-q10sx1dm	119	21	target	target	VB
cord-015684-q10sx1dm	119	22	sequences	sequence	NNS
cord-015684-q10sx1dm	119	23	located	locate	VBN
cord-015684-q10sx1dm	119	24	in	in	IN
cord-015684-q10sx1dm	119	25	3′	3′	CD
cord-015684-q10sx1dm	119	26	UTRs	utr	NNS
cord-015684-q10sx1dm	119	27	where	where	WRB
cord-015684-q10sx1dm	119	28	by	by	IN
cord-015684-q10sx1dm	119	29	incomplete	incomplete	JJ
cord-015684-q10sx1dm	119	30	base	base	NN
cord-015684-q10sx1dm	119	31	-	-	HYPH
cord-015684-q10sx1dm	119	32	pairing	pairing	NN
cord-015684-q10sx1dm	120	1	induce	induce	VB
cord-015684-q10sx1dm	120	2	mRNA	mRNA	NNP
cord-015684-q10sx1dm	120	3	destabilization	destabilization	NN
cord-015684-q10sx1dm	120	4	or	or	CC
cord-015684-q10sx1dm	120	5	translational	translational	JJ
cord-015684-q10sx1dm	120	6	repression	repression	NN
cord-015684-q10sx1dm	120	7	of	of	IN
cord-015684-q10sx1dm	120	8	the	the	DT
cord-015684-q10sx1dm	120	9	target	target	NN
cord-015684-q10sx1dm	120	10	genes	gene	NNS
cord-015684-q10sx1dm	120	11	.	.	.
cord-015684-q10sx1dm	121	1	An	an	DT
cord-015684-q10sx1dm	121	2	inventory	inventory	NN
cord-015684-q10sx1dm	121	3	of	of	IN
cord-015684-q10sx1dm	121	4	miRNA	miRNA	NNP
cord-015684-q10sx1dm	121	5	expression	expression	NN
cord-015684-q10sx1dm	121	6	profi	profi	NNP
cord-015684-q10sx1dm	121	7	les	les	NNP
cord-015684-q10sx1dm	121	8	from	from	IN
cord-015684-q10sx1dm	121	9	13	13	CD
cord-015684-q10sx1dm	121	10	regions	region	NNS
cord-015684-q10sx1dm	121	11	of	of	IN
cord-015684-q10sx1dm	121	12	the	the	DT
cord-015684-q10sx1dm	121	13	mouse	mouse	NN
cord-015684-q10sx1dm	121	14	CNS	CNS	NNP
cord-015684-q10sx1dm	121	15	has	have	VBZ
cord-015684-q10sx1dm	121	16	been	be	VBN
cord-015684-q10sx1dm	121	17	reported	report	VBN
cord-015684-q10sx1dm	121	18	.	.	.
cord-015684-q10sx1dm	122	1	58	58	CD
cord-015684-q10sx1dm	123	1	This	this	DT
cord-015684-q10sx1dm	123	2	inventory	inventory	NN
cord-015684-q10sx1dm	123	3	of	of	IN
cord-015684-q10sx1dm	123	4	CNS	CNS	NNP
cord-015684-q10sx1dm	123	5	miRNA	miRNA	NNP
cord-015684-q10sx1dm	123	6	profi	profi	NNP
cord-015684-q10sx1dm	123	7	les	les	NNP
cord-015684-q10sx1dm	123	8	provides	provide	VBZ
cord-015684-q10sx1dm	123	9	an	an	DT
cord-015684-q10sx1dm	123	10	important	important	JJ
cord-015684-q10sx1dm	123	11	step	step	NN
cord-015684-q10sx1dm	123	12	toward	toward	IN
cord-015684-q10sx1dm	123	13	further	further	JJ
cord-015684-q10sx1dm	123	14	elucidation	elucidation	NN
cord-015684-q10sx1dm	123	15	of	of	IN
cord-015684-q10sx1dm	123	16	miRNA	miRNA	NNP
cord-015684-q10sx1dm	123	17	function	function	NN
cord-015684-q10sx1dm	123	18	and	and	CC
cord-015684-q10sx1dm	123	19	miRNA	miRNA	NNP
cord-015684-q10sx1dm	123	20	-	-	HYPH
cord-015684-q10sx1dm	123	21	related	relate	VBN
cord-015684-q10sx1dm	123	22	gene	gene	NN
cord-015684-q10sx1dm	123	23	regulatory	regulatory	JJ
cord-015684-q10sx1dm	123	24	networks	network	NNS
cord-015684-q10sx1dm	123	25	in	in	IN
cord-015684-q10sx1dm	123	26	the	the	DT
cord-015684-q10sx1dm	123	27	mammalian	mammalian	JJ
cord-015684-q10sx1dm	123	28	CNS	CNS	NNP
cord-015684-q10sx1dm	123	29	.	.	.
cord-015684-q10sx1dm	124	1	58	58	CD
cord-015684-q10sx1dm	125	1	The	the	DT
cord-015684-q10sx1dm	125	2	introduction	introduction	NN
cord-015684-q10sx1dm	125	3	of	of	IN
cord-015684-q10sx1dm	125	4	novel	novel	JJ
cord-015684-q10sx1dm	125	5	procedures	procedure	NNS
cord-015684-q10sx1dm	125	6	into	into	IN
cord-015684-q10sx1dm	125	7	an	an	DT
cord-015684-q10sx1dm	125	8	integral	integral	JJ
cord-015684-q10sx1dm	125	9	genomic	genomic	JJ
cord-015684-q10sx1dm	125	10	medicine	medicine	NN
cord-015684-q10sx1dm	125	11	protocol	protocol	NN
cord-015684-q10sx1dm	125	12	for	for	IN
cord-015684-q10sx1dm	125	13	CNS	CNS	NNP
cord-015684-q10sx1dm	125	14	disorders	disorder	NNS
cord-015684-q10sx1dm	125	15	is	be	VBZ
cord-015684-q10sx1dm	125	16	an	an	DT
cord-015684-q10sx1dm	125	17	imperative	imperative	JJ
cord-015684-q10sx1dm	125	18	requirement	requirement	NN
cord-015684-q10sx1dm	125	19	in	in	IN
cord-015684-q10sx1dm	125	20	drug	drug	NN
cord-015684-q10sx1dm	125	21	development	development	NN
cord-015684-q10sx1dm	125	22	and	and	CC
cord-015684-q10sx1dm	125	23	in	in	IN
cord-015684-q10sx1dm	125	24	the	the	DT
cord-015684-q10sx1dm	125	25	clinical	clinical	JJ
cord-015684-q10sx1dm	125	26	practice	practice	NN
cord-015684-q10sx1dm	125	27	to	to	TO
cord-015684-q10sx1dm	125	28	improve	improve	VB
cord-015684-q10sx1dm	125	29	diagnostic	diagnostic	JJ
cord-015684-q10sx1dm	125	30	accuracy	accuracy	NN
cord-015684-q10sx1dm	125	31	and	and	CC
cord-015684-q10sx1dm	125	32	to	to	TO
cord-015684-q10sx1dm	125	33	optimize	optimize	VB
cord-015684-q10sx1dm	125	34	therapeutics	therapeutic	NNS
cord-015684-q10sx1dm	125	35	.	.	.
cord-015684-q10sx1dm	126	1	This	this	DT
cord-015684-q10sx1dm	126	2	kind	kind	NN
cord-015684-q10sx1dm	126	3	of	of	IN
cord-015684-q10sx1dm	126	4	protocol	protocol	NN
cord-015684-q10sx1dm	126	5	should	should	MD
cord-015684-q10sx1dm	126	6	integrate	integrate	VB
cord-015684-q10sx1dm	126	7	the	the	DT
cord-015684-q10sx1dm	126	8	following	follow	VBG
cord-015684-q10sx1dm	126	9	components	component	NNS
cord-015684-q10sx1dm	126	10	:	:	:
cord-015684-q10sx1dm	126	11	(	(	-LRB-
cord-015684-q10sx1dm	126	12	i	i	NN
cord-015684-q10sx1dm	126	13	)	)	-RRB-
cord-015684-q10sx1dm	126	14	clinical	clinical	JJ
cord-015684-q10sx1dm	126	15	history	history	NN
cord-015684-q10sx1dm	126	16	,	,	.
cord-015684-q10sx1dm	127	1	(	(	-LRB-
cord-015684-q10sx1dm	127	2	ii	ii	LS
cord-015684-q10sx1dm	127	3	)	)	-RRB-
cord-015684-q10sx1dm	127	4	laboratory	laboratory	NN
cord-015684-q10sx1dm	127	5	tests	test	NNS
cord-015684-q10sx1dm	127	6	,	,	,
cord-015684-q10sx1dm	127	7	(	(	-LRB-
cord-015684-q10sx1dm	127	8	iii	iii	NN
cord-015684-q10sx1dm	127	9	)	)	-RRB-
cord-015684-q10sx1dm	127	10	neuropsychological	neuropsychological	JJ
cord-015684-q10sx1dm	127	11	assessment	assessment	NN
cord-015684-q10sx1dm	127	12	,	,	,
cord-015684-q10sx1dm	127	13	(	(	-LRB-
cord-015684-q10sx1dm	127	14	iv	iv	LS
cord-015684-q10sx1dm	127	15	)	)	-RRB-
cord-015684-q10sx1dm	127	16	cardiovascular	cardiovascular	JJ
cord-015684-q10sx1dm	127	17	evaluation	evaluation	NN
cord-015684-q10sx1dm	127	18	,	,	,
cord-015684-q10sx1dm	127	19	(	(	-LRB-
cord-015684-q10sx1dm	127	20	v	v	NN
cord-015684-q10sx1dm	127	21	)	)	-RRB-
cord-015684-q10sx1dm	127	22	conventional	conventional	JJ
cord-015684-q10sx1dm	127	23	X	x	NN
cord-015684-q10sx1dm	127	24	-	-	NN
cord-015684-q10sx1dm	127	25	ray	ray	NN
cord-015684-q10sx1dm	127	26	technology	technology	NN
cord-015684-q10sx1dm	127	27	,	,	,
cord-015684-q10sx1dm	127	28	(	(	-LRB-
cord-015684-q10sx1dm	127	29	vi	vi	NNP
cord-015684-q10sx1dm	127	30	)	)	-RRB-
cord-015684-q10sx1dm	127	31	structural	structural	JJ
cord-015684-q10sx1dm	127	32	neuroimaging	neuroimaging	NN
cord-015684-q10sx1dm	127	33	,	,	,
cord-015684-q10sx1dm	127	34	(	(	-LRB-
cord-015684-q10sx1dm	127	35	vii	vii	NN
cord-015684-q10sx1dm	127	36	)	)	-RRB-
cord-015684-q10sx1dm	127	37	functional	functional	JJ
cord-015684-q10sx1dm	127	38	neuroimaging	neuroimaging	NN
cord-015684-q10sx1dm	127	39	,	,	,
cord-015684-q10sx1dm	127	40	(	(	-LRB-
cord-015684-q10sx1dm	127	41	viii	viii	NNP
cord-015684-q10sx1dm	127	42	)	)	-RRB-
cord-015684-q10sx1dm	127	43	computerized	computerized	JJ
cord-015684-q10sx1dm	127	44	brain	brain	NN
cord-015684-q10sx1dm	127	45	electrophysiology	electrophysiology	NN
cord-015684-q10sx1dm	127	46	,	,	,
cord-015684-q10sx1dm	127	47	(	(	-LRB-
cord-015684-q10sx1dm	127	48	ix	ix	NNP
cord-015684-q10sx1dm	127	49	)	)	-RRB-
cord-015684-q10sx1dm	127	50	cerebrovascular	cerebrovascular	JJ
cord-015684-q10sx1dm	127	51	evaluation	evaluation	NN
cord-015684-q10sx1dm	127	52	,	,	,
cord-015684-q10sx1dm	127	53	(	(	-LRB-
cord-015684-q10sx1dm	127	54	x	x	LS
cord-015684-q10sx1dm	127	55	)	)	-RRB-
cord-015684-q10sx1dm	127	56	structural	structural	JJ
cord-015684-q10sx1dm	127	57	genomics	genomic	NNS
cord-015684-q10sx1dm	127	58	,	,	,
cord-015684-q10sx1dm	127	59	(	(	-LRB-
cord-015684-q10sx1dm	127	60	xi	xi	NNP
cord-015684-q10sx1dm	127	61	)	)	-RRB-
cord-015684-q10sx1dm	127	62	functional	functional	JJ
cord-015684-q10sx1dm	127	63	genomics	genomic	NNS
cord-015684-q10sx1dm	127	64	,	,	,
cord-015684-q10sx1dm	127	65	(	(	-LRB-
cord-015684-q10sx1dm	127	66	xii	xii	NNP
cord-015684-q10sx1dm	127	67	)	)	-RRB-
cord-015684-q10sx1dm	127	68	pharmacogenetics	pharmacogenetics	NNP
cord-015684-q10sx1dm	127	69	,	,	,
cord-015684-q10sx1dm	127	70	(	(	-LRB-
cord-015684-q10sx1dm	127	71	xiii	xiii	NNP
cord-015684-q10sx1dm	127	72	)	)	-RRB-
cord-015684-q10sx1dm	127	73	pharmacogenomics	pharmacogenomics	NNP
cord-015684-q10sx1dm	127	74	,	,	,
cord-015684-q10sx1dm	127	75	(	(	-LRB-
cord-015684-q10sx1dm	127	76	ix	ix	NNP
cord-015684-q10sx1dm	127	77	)	)	-RRB-
cord-015684-q10sx1dm	127	78	nutrigenetics	nutrigenetics	NNPS
cord-015684-q10sx1dm	127	79	,	,	,
cord-015684-q10sx1dm	127	80	(	(	-LRB-
cord-015684-q10sx1dm	127	81	x	x	NN
cord-015684-q10sx1dm	127	82	)	)	-RRB-
cord-015684-q10sx1dm	127	83	nutrigenomics	nutrigenomic	NNS
cord-015684-q10sx1dm	127	84	,	,	,
cord-015684-q10sx1dm	127	85	(	(	-LRB-
cord-015684-q10sx1dm	127	86	xi	xi	NNP
cord-015684-q10sx1dm	127	87	)	)	-RRB-
cord-015684-q10sx1dm	127	88	bioinformatics	bioinformatics	NNP
cord-015684-q10sx1dm	127	89	for	for	IN
cord-015684-q10sx1dm	127	90	data	datum	NNS
cord-015684-q10sx1dm	127	91	management	management	NN
cord-015684-q10sx1dm	127	92	,	,	,
cord-015684-q10sx1dm	127	93	and	and	CC
cord-015684-q10sx1dm	128	1	(	(	-LRB-
cord-015684-q10sx1dm	128	2	xii	xii	NNP
cord-015684-q10sx1dm	128	3	)	)	-RRB-
cord-015684-q10sx1dm	128	4	artifi	artifi	NNP
cord-015684-q10sx1dm	128	5	cial	cial	JJ
cord-015684-q10sx1dm	128	6	intelligence	intelligence	NN
cord-015684-q10sx1dm	128	7	procedures	procedure	NNS
cord-015684-q10sx1dm	128	8	for	for	IN
cord-015684-q10sx1dm	128	9	diagnostic	diagnostic	JJ
cord-015684-q10sx1dm	128	10	assignments	assignment	NNS
cord-015684-q10sx1dm	128	11	and	and	CC
cord-015684-q10sx1dm	128	12	probabilistic	probabilistic	JJ
cord-015684-q10sx1dm	128	13	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	128	14	options	option	NNS
cord-015684-q10sx1dm	129	1	(	(	-LRB-
cord-015684-q10sx1dm	129	2	Table	table	NN
cord-015684-q10sx1dm	129	3	40	40	CD
cord-015684-q10sx1dm	129	4	.4	.4	CD
cord-015684-q10sx1dm	129	5	)	)	-RRB-
cord-015684-q10sx1dm	129	6	.	.	.
cord-015684-q10sx1dm	130	1	2	2	LS
cord-015684-q10sx1dm	130	2	,	,	,
cord-015684-q10sx1dm	130	3	8	8	CD
cord-015684-q10sx1dm	130	4	,	,	,
cord-015684-q10sx1dm	130	5	[	[	-LRB-
cord-015684-q10sx1dm	130	6	16	16	CD
cord-015684-q10sx1dm	130	7	]	]	-RRB-
cord-015684-q10sx1dm	130	8	[	[	-LRB-
cord-015684-q10sx1dm	130	9	17	17	CD
cord-015684-q10sx1dm	130	10	]	]	-RRB-
cord-015684-q10sx1dm	130	11	[	[	-LRB-
cord-015684-q10sx1dm	130	12	18	18	CD
cord-015684-q10sx1dm	130	13	]	]	-RRB-
cord-015684-q10sx1dm	130	14	[	[	-LRB-
cord-015684-q10sx1dm	130	15	19	19	CD
cord-015684-q10sx1dm	130	16	]	]	-RRB-
cord-015684-q10sx1dm	131	1	[	[	-LRB-
cord-015684-q10sx1dm	131	2	20	20	CD
cord-015684-q10sx1dm	131	3	]	]	-RRB-
cord-015684-q10sx1dm	131	4	[	[	-LRB-
cord-015684-q10sx1dm	131	5	21	21	CD
cord-015684-q10sx1dm	131	6	]	]	-RRB-
cord-015684-q10sx1dm	132	1	[	[	-LRB-
cord-015684-q10sx1dm	132	2	22	22	CD
cord-015684-q10sx1dm	132	3	]	]	-RRB-
cord-015684-q10sx1dm	132	4	59	59	CD
cord-015684-q10sx1dm	132	5	,	,	,
cord-015684-q10sx1dm	132	6	60	60	CD
cord-015684-q10sx1dm	133	1	All	all	PDT
cord-015684-q10sx1dm	133	2	these	these	DT
cord-015684-q10sx1dm	133	3	procedures	procedure	NNS
cord-015684-q10sx1dm	133	4	,	,	,
cord-015684-q10sx1dm	133	5	under	under	IN
cord-015684-q10sx1dm	133	6	personalized	personalized	JJ
cord-015684-q10sx1dm	133	7	strategies	strategy	NNS
cord-015684-q10sx1dm	133	8	adapted	adapt	VBN
cord-015684-q10sx1dm	133	9	to	to	IN
cord-015684-q10sx1dm	133	10	the	the	DT
cord-015684-q10sx1dm	133	11	complexity	complexity	NN
cord-015684-q10sx1dm	133	12	of	of	IN
cord-015684-q10sx1dm	133	13	each	each	DT
cord-015684-q10sx1dm	133	14	case	case	NN
cord-015684-q10sx1dm	133	15	,	,	,
cord-015684-q10sx1dm	133	16	are	be	VBP
cord-015684-q10sx1dm	133	17	essential	essential	JJ
cord-015684-q10sx1dm	133	18	to	to	TO
cord-015684-q10sx1dm	133	19	depict	depict	VB
cord-015684-q10sx1dm	133	20	a	a	DT
cord-015684-q10sx1dm	133	21	clinical	clinical	JJ
cord-015684-q10sx1dm	133	22	profi	profi	NNP
cord-015684-q10sx1dm	133	23	le	le	NNP
cord-015684-q10sx1dm	133	24	based	base	VBN
cord-015684-q10sx1dm	133	25	on	on	IN
cord-015684-q10sx1dm	133	26	specifi	specifi	NNP
cord-015684-q10sx1dm	133	27	c	c	NN
cord-015684-q10sx1dm	133	28	biomarkers	biomarker	NNS
cord-015684-q10sx1dm	133	29	correlating	correlate	VBG
cord-015684-q10sx1dm	133	30	with	with	IN
cord-015684-q10sx1dm	133	31	individual	individual	JJ
cord-015684-q10sx1dm	133	32	genomic	genomic	JJ
cord-015684-q10sx1dm	133	33	profi	profi	NNP
cord-015684-q10sx1dm	133	34	les	les	FW
cord-015684-q10sx1dm	133	35	.	.	.
cord-015684-q10sx1dm	134	1	Functional	functional	JJ
cord-015684-q10sx1dm	134	2	genomics	genomic	NNS
cord-015684-q10sx1dm	134	3	studies	study	NNS
cord-015684-q10sx1dm	134	4	have	have	VBP
cord-015684-q10sx1dm	134	5	demonstrated	demonstrate	VBN
cord-015684-q10sx1dm	134	6	the	the	DT
cord-015684-q10sx1dm	134	7	infl	infl	NN
cord-015684-q10sx1dm	134	8	uence	uence	NN
cord-015684-q10sx1dm	134	9	of	of	IN
cord-015684-q10sx1dm	134	10	many	many	JJ
cord-015684-q10sx1dm	134	11	genes	gene	NNS
cord-015684-q10sx1dm	134	12	on	on	IN
cord-015684-q10sx1dm	134	13	CNS	CNS	NNP
cord-015684-q10sx1dm	134	14	pathogenesis	pathogenesis	NN
cord-015684-q10sx1dm	134	15	and	and	CC
cord-015684-q10sx1dm	134	16	phenotype	phenotype	NN
cord-015684-q10sx1dm	134	17	expression	expression	NN
cord-015684-q10sx1dm	134	18	(	(	-LRB-
cord-015684-q10sx1dm	134	19	Tables	table	NNS
cord-015684-q10sx1dm	134	20	40.1	40.1	CD
cord-015684-q10sx1dm	134	21	-	-	SYM
cord-015684-q10sx1dm	134	22	40	40	CD
cord-015684-q10sx1dm	134	23	.	.	.
cord-015684-q10sx1dm	134	24	3	3	CD
cord-015684-q10sx1dm	134	25	)	)	-RRB-
cord-015684-q10sx1dm	134	26	.	.	.
cord-015684-q10sx1dm	135	1	Taking	take	VBG
cord-015684-q10sx1dm	135	2	AD	ad	NN
cord-015684-q10sx1dm	135	3	as	as	IN
cord-015684-q10sx1dm	135	4	an	an	DT
cord-015684-q10sx1dm	135	5	example	example	NN
cord-015684-q10sx1dm	135	6	,	,	,
cord-015684-q10sx1dm	135	7	it	-PRON-	PRP
cord-015684-q10sx1dm	135	8	has	have	VBZ
cord-015684-q10sx1dm	135	9	been	be	VBN
cord-015684-q10sx1dm	135	10	demonstrated	demonstrate	VBN
cord-015684-q10sx1dm	135	11	that	that	IN
cord-015684-q10sx1dm	135	12	mutations	mutation	NNS
cord-015684-q10sx1dm	135	13	in	in	IN
cord-015684-q10sx1dm	135	14	the	the	DT
cord-015684-q10sx1dm	135	15	APP	app	NN
cord-015684-q10sx1dm	135	16	,	,	,
cord-015684-q10sx1dm	135	17	PS1	PS1	NNP
cord-015684-q10sx1dm	135	18	,	,	,
cord-015684-q10sx1dm	135	19	PS2	PS2	NNP
cord-015684-q10sx1dm	135	20	,	,	,
cord-015684-q10sx1dm	135	21	and	and	CC
cord-015684-q10sx1dm	135	22	MAPT	MAPT	NNP
cord-015684-q10sx1dm	135	23	genes	gene	NNS
cord-015684-q10sx1dm	135	24	give	give	VBP
cord-015684-q10sx1dm	135	25	rise	rise	NN
cord-015684-q10sx1dm	135	26	to	to	IN
cord-015684-q10sx1dm	135	27	wellcharacterized	wellcharacterized	JJ
cord-015684-q10sx1dm	135	28	differential	differential	JJ
cord-015684-q10sx1dm	135	29	neuropathological	neuropathological	JJ
cord-015684-q10sx1dm	135	30	and	and	CC
cord-015684-q10sx1dm	135	31	clinical	clinical	JJ
cord-015684-q10sx1dm	135	32	phenotypes	phenotype	NNS
cord-015684-q10sx1dm	135	33	of	of	IN
cord-015684-q10sx1dm	135	34	dementia	dementia	NN
cord-015684-q10sx1dm	135	35	.	.	.
cord-015684-q10sx1dm	136	1	8	8	CD
cord-015684-q10sx1dm	137	1	The	the	DT
cord-015684-q10sx1dm	137	2	analysis	analysis	NN
cord-015684-q10sx1dm	137	3	of	of	IN
cord-015684-q10sx1dm	137	4	genotypephenotype	genotypephenotype	NN
cord-015684-q10sx1dm	137	5	correlations	correlation	NNS
cord-015684-q10sx1dm	137	6	has	have	VBZ
cord-015684-q10sx1dm	137	7	also	also	RB
cord-015684-q10sx1dm	137	8	revealed	reveal	VBN
cord-015684-q10sx1dm	137	9	that	that	IN
cord-015684-q10sx1dm	137	10	the	the	DT
cord-015684-q10sx1dm	137	11	presence	presence	NN
cord-015684-q10sx1dm	137	12	of	of	IN
cord-015684-q10sx1dm	137	13	the	the	DT
cord-015684-q10sx1dm	137	14	APOE-4	APOE-4	NNP
cord-015684-q10sx1dm	137	15	allele	allele	NN
cord-015684-q10sx1dm	137	16	in	in	IN
cord-015684-q10sx1dm	137	17	AD	ad	NN
cord-015684-q10sx1dm	137	18	,	,	,
cord-015684-q10sx1dm	137	19	in	in	IN
cord-015684-q10sx1dm	137	20	conjunction	conjunction	NN
cord-015684-q10sx1dm	137	21	with	with	IN
cord-015684-q10sx1dm	137	22	other	other	JJ
cord-015684-q10sx1dm	137	23	genes	gene	NNS
cord-015684-q10sx1dm	137	24	,	,	,
cord-015684-q10sx1dm	137	25	infl	infl	NNP
cord-015684-q10sx1dm	137	26	uences	uences	NNP
cord-015684-q10sx1dm	137	27	disease	disease	NN
cord-015684-q10sx1dm	137	28	onset	onset	NN
cord-015684-q10sx1dm	137	29	,	,	,
cord-015684-q10sx1dm	137	30	brain	brain	NN
cord-015684-q10sx1dm	137	31	atrophy	atrophy	NN
cord-015684-q10sx1dm	137	32	,	,	,
cord-015684-q10sx1dm	137	33	cerebrovascular	cerebrovascular	JJ
cord-015684-q10sx1dm	137	34	perfusion	perfusion	NN
cord-015684-q10sx1dm	137	35	,	,	,
cord-015684-q10sx1dm	137	36	blood	blood	NN
cord-015684-q10sx1dm	137	37	pressure	pressure	NN
cord-015684-q10sx1dm	137	38	,	,	,
cord-015684-q10sx1dm	137	39	β	β	NN
cord-015684-q10sx1dm	137	40	-	-	HYPH
cord-015684-q10sx1dm	137	41	amyloid	amyloid	JJ
cord-015684-q10sx1dm	137	42	deposition	deposition	NN
cord-015684-q10sx1dm	137	43	,	,	,
cord-015684-q10sx1dm	137	44	ApoE	ApoE	NNP
cord-015684-q10sx1dm	137	45	secretion	secretion	NN
cord-015684-q10sx1dm	137	46	,	,	,
cord-015684-q10sx1dm	137	47	lipid	lipid	NN
cord-015684-q10sx1dm	137	48	metabolism	metabolism	NN
cord-015684-q10sx1dm	137	49	,	,	,
cord-015684-q10sx1dm	137	50	brain	brain	NN
cord-015684-q10sx1dm	137	51	bioelectrical	bioelectrical	JJ
cord-015684-q10sx1dm	137	52	activity	activity	NN
cord-015684-q10sx1dm	137	53	,	,	,
cord-015684-q10sx1dm	137	54	cognition	cognition	NN
cord-015684-q10sx1dm	137	55	,	,	,
cord-015684-q10sx1dm	137	56	apoptosis	apoptosis	NN
cord-015684-q10sx1dm	137	57	,	,	,
cord-015684-q10sx1dm	137	58	and	and	CC
cord-015684-q10sx1dm	137	59	treatment	treatment	NN
cord-015684-q10sx1dm	137	60	outcome	outcome	NN
cord-015684-q10sx1dm	137	61	.	.	.
cord-015684-q10sx1dm	138	1	8	8	CD
cord-015684-q10sx1dm	138	2	,	,	,
cord-015684-q10sx1dm	138	3	[	[	-LRB-
cord-015684-q10sx1dm	138	4	16	16	CD
cord-015684-q10sx1dm	138	5	]	]	-RRB-
cord-015684-q10sx1dm	139	1	[	[	-LRB-
cord-015684-q10sx1dm	139	2	17	17	CD
cord-015684-q10sx1dm	139	3	]	]	-RRB-
cord-015684-q10sx1dm	139	4	[	[	-LRB-
cord-015684-q10sx1dm	139	5	18	18	CD
cord-015684-q10sx1dm	139	6	]	]	-RRB-
cord-015684-q10sx1dm	139	7	[	[	-LRB-
cord-015684-q10sx1dm	139	8	19	19	CD
cord-015684-q10sx1dm	139	9	]	]	-RRB-
cord-015684-q10sx1dm	140	1	[	[	-LRB-
cord-015684-q10sx1dm	140	2	20	20	CD
cord-015684-q10sx1dm	140	3	]	]	-RRB-
cord-015684-q10sx1dm	140	4	[	[	-LRB-
cord-015684-q10sx1dm	140	5	21	21	CD
cord-015684-q10sx1dm	140	6	]	]	-RRB-
cord-015684-q10sx1dm	140	7	[	[	-LRB-
cord-015684-q10sx1dm	140	8	22	22	CD
cord-015684-q10sx1dm	140	9	]	]	-RRB-
cord-015684-q10sx1dm	140	10	61	61	CD
cord-015684-q10sx1dm	141	1	The	the	DT
cord-015684-q10sx1dm	141	2	characterization	characterization	NN
cord-015684-q10sx1dm	141	3	of	of	IN
cord-015684-q10sx1dm	141	4	phenotypic	phenotypic	JJ
cord-015684-q10sx1dm	141	5	profi	profi	NNP
cord-015684-q10sx1dm	141	6	les	les	NNP
cord-015684-q10sx1dm	141	7	according	accord	VBG
cord-015684-q10sx1dm	141	8	to	to	IN
cord-015684-q10sx1dm	141	9	age	age	NN
cord-015684-q10sx1dm	141	10	,	,	,
cord-015684-q10sx1dm	141	11	cognitive	cognitive	JJ
cord-015684-q10sx1dm	141	12	performance	performance	NN
cord-015684-q10sx1dm	141	13	(	(	-LRB-
cord-015684-q10sx1dm	141	14	MMSE	MMSE	NNP
cord-015684-q10sx1dm	141	15	and	and	CC
cord-015684-q10sx1dm	141	16	ADAS	ADAS	NNP
cord-015684-q10sx1dm	141	17	-	-	HYPH
cord-015684-q10sx1dm	141	18	Cog	cog	NN
cord-015684-q10sx1dm	141	19	score	score	NN
cord-015684-q10sx1dm	141	20	)	)	-RRB-
cord-015684-q10sx1dm	141	21	,	,	,
cord-015684-q10sx1dm	141	22	serum	serum	NN
cord-015684-q10sx1dm	141	23	ApoE	ApoE	NNS
cord-015684-q10sx1dm	141	24	levels	level	NNS
cord-015684-q10sx1dm	141	25	,	,	,
cord-015684-q10sx1dm	141	26	serum	serum	NN
cord-015684-q10sx1dm	141	27	lipid	lipid	NN
cord-015684-q10sx1dm	141	28	levels	level	NNS
cord-015684-q10sx1dm	141	29	including	include	VBG
cord-015684-q10sx1dm	141	30	cholesterol	cholesterol	NN
cord-015684-q10sx1dm	141	31	(	(	-LRB-
cord-015684-q10sx1dm	141	32	CHO	CHO	NNP
cord-015684-q10sx1dm	141	33	)	)	-RRB-
cord-015684-q10sx1dm	141	34	,	,	,
cord-015684-q10sx1dm	141	35	HDL	HDL	NNP
cord-015684-q10sx1dm	141	36	-	-	HYPH
cord-015684-q10sx1dm	141	37	CHO	CHO	NNP
cord-015684-q10sx1dm	141	38	,	,	,
cord-015684-q10sx1dm	141	39	LDL	LDL	NNP
cord-015684-q10sx1dm	141	40	-	-	HYPH
cord-015684-q10sx1dm	141	41	CHO	CHO	NNP
cord-015684-q10sx1dm	141	42	,	,	,
cord-015684-q10sx1dm	141	43	VLDL	VLDL	NNP
cord-015684-q10sx1dm	141	44	-	-	HYPH
cord-015684-q10sx1dm	141	45	CHO	CHO	NNP
cord-015684-q10sx1dm	141	46	,	,	,
cord-015684-q10sx1dm	141	47	and	and	CC
cord-015684-q10sx1dm	141	48	triglyceride	triglyceride	NN
cord-015684-q10sx1dm	141	49	(	(	-LRB-
cord-015684-q10sx1dm	141	50	TG	TG	NNP
cord-015684-q10sx1dm	141	51	)	)	-RRB-
cord-015684-q10sx1dm	141	52	levels	level	NNS
cord-015684-q10sx1dm	141	53	,	,	,
cord-015684-q10sx1dm	141	54	as	as	RB
cord-015684-q10sx1dm	141	55	well	well	RB
cord-015684-q10sx1dm	141	56	as	as	IN
cord-015684-q10sx1dm	141	57	serum	serum	NN
cord-015684-q10sx1dm	141	58	nitric	nitric	NN
cord-015684-q10sx1dm	141	59	oxide	oxide	NN
cord-015684-q10sx1dm	141	60	(	(	-LRB-
cord-015684-q10sx1dm	141	61	NO	no	UH
cord-015684-q10sx1dm	141	62	)	)	-RRB-
cord-015684-q10sx1dm	141	63	,	,	,
cord-015684-q10sx1dm	141	64	β	β	NN
cord-015684-q10sx1dm	141	65	-	-	HYPH
cord-015684-q10sx1dm	141	66	amyloid	amyloid	NN
cord-015684-q10sx1dm	141	67	,	,	,
cord-015684-q10sx1dm	141	68	and	and	CC
cord-015684-q10sx1dm	141	69	histamine	histamine	NN
cord-015684-q10sx1dm	141	70	levels	level	NNS
cord-015684-q10sx1dm	141	71	,	,	,
cord-015684-q10sx1dm	141	72	reveals	reveal	VBZ
cord-015684-q10sx1dm	141	73	sex	sex	NN
cord-015684-q10sx1dm	141	74	-	-	HYPH
cord-015684-q10sx1dm	141	75	related	relate	VBN
cord-015684-q10sx1dm	141	76	differences	difference	NNS
cord-015684-q10sx1dm	141	77	in	in	IN
cord-015684-q10sx1dm	141	78	25	25	CD
cord-015684-q10sx1dm	141	79	%	%	NN
cord-015684-q10sx1dm	141	80	of	of	IN
cord-015684-q10sx1dm	141	81	the	the	DT
cord-015684-q10sx1dm	141	82	biological	biological	JJ
cord-015684-q10sx1dm	141	83	parameters	parameter	NNS
cord-015684-q10sx1dm	141	84	and	and	CC
cord-015684-q10sx1dm	141	85	almost	almost	RB
cord-015684-q10sx1dm	141	86	no	no	DT
cord-015684-q10sx1dm	141	87	differences	difference	NNS
cord-015684-q10sx1dm	141	88	(	(	-LRB-
cord-015684-q10sx1dm	141	89	0.24	0.24	CD
cord-015684-q10sx1dm	141	90	%	%	NN
cord-015684-q10sx1dm	141	91	)	)	-RRB-
cord-015684-q10sx1dm	141	92	when	when	WRB
cord-015684-q10sx1dm	141	93	patients	patient	NNS
cord-015684-q10sx1dm	141	94	are	be	VBP
cord-015684-q10sx1dm	141	95	classifi	classifi	NNS
cord-015684-q10sx1dm	141	96	ed	ed	NN
cord-015684-q10sx1dm	141	97	as	as	IN
cord-015684-q10sx1dm	141	98	APOE-4(−	APOE-4(−	NNP
cord-015684-q10sx1dm	141	99	)	)	-RRB-
cord-015684-q10sx1dm	141	100	and	and	CC
cord-015684-q10sx1dm	141	101	APOE-4(+	APOE-4(+	NNP
cord-015684-q10sx1dm	141	102	)	)	-RRB-
cord-015684-q10sx1dm	141	103	carriers	carrier	NNS
cord-015684-q10sx1dm	141	104	,	,	,
cord-015684-q10sx1dm	141	105	probably	probably	RB
cord-015684-q10sx1dm	141	106	indicating	indicate	VBG
cord-015684-q10sx1dm	141	107	that	that	IN
cord-015684-q10sx1dm	141	108	genderrelated	genderrelate	VBN
cord-015684-q10sx1dm	141	109	factors	factor	NNS
cord-015684-q10sx1dm	141	110	may	may	MD
cord-015684-q10sx1dm	141	111	infl	infl	VB
cord-015684-q10sx1dm	141	112	uence	uence	VB
cord-015684-q10sx1dm	141	113	these	these	DT
cord-015684-q10sx1dm	141	114	parametric	parametric	JJ
cord-015684-q10sx1dm	141	115	variables	variable	NNS
cord-015684-q10sx1dm	141	116	more	more	RBR
cord-015684-q10sx1dm	141	117	powerfully	powerfully	RB
cord-015684-q10sx1dm	141	118	than	than	IN
cord-015684-q10sx1dm	141	119	the	the	DT
cord-015684-q10sx1dm	141	120	presence	presence	NN
cord-015684-q10sx1dm	141	121	or	or	CC
cord-015684-q10sx1dm	141	122	absence	absence	NN
cord-015684-q10sx1dm	141	123	of	of	IN
cord-015684-q10sx1dm	141	124	the	the	DT
cord-015684-q10sx1dm	141	125	APOE-4	APOE-4	NNP
cord-015684-q10sx1dm	141	126	allele	allele	NN
cord-015684-q10sx1dm	141	127	;	;	:
cord-015684-q10sx1dm	141	128	in	in	IN
cord-015684-q10sx1dm	141	129	contrast	contrast	NN
cord-015684-q10sx1dm	141	130	,	,	,
cord-015684-q10sx1dm	141	131	when	when	WRB
cord-015684-q10sx1dm	141	132	patients	patient	NNS
cord-015684-q10sx1dm	141	133	are	be	VBP
cord-015684-q10sx1dm	141	134	classifi	classifi	NNP
cord-015684-q10sx1dm	141	135	ed	ed	NN
cord-015684-q10sx1dm	141	136	according	accord	VBG
cord-015684-q10sx1dm	141	137	to	to	IN
cord-015684-q10sx1dm	141	138	their	-PRON-	PRP$
cord-015684-q10sx1dm	141	139	APOE	APOE	NNP
cord-015684-q10sx1dm	141	140	genotype	genotype	NN
cord-015684-q10sx1dm	141	141	,	,	,
cord-015684-q10sx1dm	141	142	dramatic	dramatic	JJ
cord-015684-q10sx1dm	141	143	differences	difference	NNS
cord-015684-q10sx1dm	141	144	emerge	emerge	VBP
cord-015684-q10sx1dm	141	145	among	among	IN
cord-015684-q10sx1dm	141	146	APOE	apoe	NN
cord-015684-q10sx1dm	141	147	genotypes	genotype	NNS
cord-015684-q10sx1dm	141	148	(	(	-LRB-
cord-015684-q10sx1dm	141	149	>	>	NFP
cord-015684-q10sx1dm	141	150	45	45	CD
cord-015684-q10sx1dm	141	151	%	%	NN
cord-015684-q10sx1dm	141	152	)	)	-RRB-
cord-015684-q10sx1dm	141	153	,	,	,
cord-015684-q10sx1dm	141	154	with	with	IN
cord-015684-q10sx1dm	141	155	a	a	DT
cord-015684-q10sx1dm	141	156	clear	clear	JJ
cord-015684-q10sx1dm	141	157	biological	biological	JJ
cord-015684-q10sx1dm	141	158	disadvantage	disadvantage	NN
cord-015684-q10sx1dm	141	159	in	in	IN
cord-015684-q10sx1dm	141	160	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	141	161	carriers	carrier	NNS
cord-015684-q10sx1dm	141	162	who	who	WP
cord-015684-q10sx1dm	141	163	exhibit	exhibit	VBP
cord-015684-q10sx1dm	141	164	(	(	-LRB-
cord-015684-q10sx1dm	141	165	i	i	NN
cord-015684-q10sx1dm	141	166	)	)	-RRB-
cord-015684-q10sx1dm	141	167	earlier	early	JJR
cord-015684-q10sx1dm	141	168	age	age	NN
cord-015684-q10sx1dm	141	169	of	of	IN
cord-015684-q10sx1dm	141	170	onset	onset	NN
cord-015684-q10sx1dm	141	171	,	,	,
cord-015684-q10sx1dm	141	172	(	(	-LRB-
cord-015684-q10sx1dm	141	173	ii	ii	NN
cord-015684-q10sx1dm	141	174	)	)	-RRB-
cord-015684-q10sx1dm	141	175	low	low	JJ
cord-015684-q10sx1dm	141	176	ApoE	ApoE	NNPS
cord-015684-q10sx1dm	141	177	levels	level	NNS
cord-015684-q10sx1dm	141	178	,	,	,
cord-015684-q10sx1dm	141	179	(	(	-LRB-
cord-015684-q10sx1dm	141	180	iii	iii	NN
cord-015684-q10sx1dm	141	181	)	)	-RRB-
cord-015684-q10sx1dm	142	1	high	high	JJ
cord-015684-q10sx1dm	142	2	CHO	CHO	NNP
cord-015684-q10sx1dm	142	3	and	and	CC
cord-015684-q10sx1dm	142	4	LDL	LDL	NNP
cord-015684-q10sx1dm	142	5	-	-	HYPH
cord-015684-q10sx1dm	142	6	CHO	CHO	NNP
cord-015684-q10sx1dm	142	7	levels	level	NNS
cord-015684-q10sx1dm	142	8	,	,	,
cord-015684-q10sx1dm	142	9	and	and	CC
cord-015684-q10sx1dm	142	10	(	(	-LRB-
cord-015684-q10sx1dm	142	11	iv	iv	LS
cord-015684-q10sx1dm	142	12	)	)	-RRB-
cord-015684-q10sx1dm	143	1	low	low	JJ
cord-015684-q10sx1dm	144	1	NO	no	UH
cord-015684-q10sx1dm	144	2	,	,	,
cord-015684-q10sx1dm	144	3	β	β	NN
cord-015684-q10sx1dm	144	4	-	-	HYPH
cord-015684-q10sx1dm	144	5	amyloid	amyloid	NN
cord-015684-q10sx1dm	144	6	,	,	,
cord-015684-q10sx1dm	144	7	and	and	CC
cord-015684-q10sx1dm	144	8	histamine	histamine	NN
cord-015684-q10sx1dm	144	9	levels	level	NNS
cord-015684-q10sx1dm	144	10	in	in	IN
cord-015684-q10sx1dm	144	11	blood	blood	NN
cord-015684-q10sx1dm	144	12	.	.	.
cord-015684-q10sx1dm	145	1	8	8	CD
cord-015684-q10sx1dm	145	2	,	,	,
cord-015684-q10sx1dm	145	3	[	[	-LRB-
cord-015684-q10sx1dm	145	4	16	16	CD
cord-015684-q10sx1dm	145	5	]	]	-RRB-
cord-015684-q10sx1dm	146	1	[	[	-LRB-
cord-015684-q10sx1dm	146	2	17	17	CD
cord-015684-q10sx1dm	146	3	]	]	-RRB-
cord-015684-q10sx1dm	146	4	[	[	-LRB-
cord-015684-q10sx1dm	146	5	18	18	CD
cord-015684-q10sx1dm	146	6	]	]	-RRB-
cord-015684-q10sx1dm	146	7	[	[	-LRB-
cord-015684-q10sx1dm	146	8	19	19	CD
cord-015684-q10sx1dm	146	9	]	]	-RRB-
cord-015684-q10sx1dm	147	1	[	[	-LRB-
cord-015684-q10sx1dm	147	2	20	20	CD
cord-015684-q10sx1dm	147	3	]	]	-RRB-
cord-015684-q10sx1dm	147	4	[	[	-LRB-
cord-015684-q10sx1dm	147	5	21	21	CD
cord-015684-q10sx1dm	147	6	]	]	-RRB-
cord-015684-q10sx1dm	147	7	[	[	-LRB-
cord-015684-q10sx1dm	147	8	22	22	CD
cord-015684-q10sx1dm	147	9	]	]	-RRB-
cord-015684-q10sx1dm	147	10	61	61	CD
cord-015684-q10sx1dm	148	1	These	these	DT
cord-015684-q10sx1dm	148	2	phenotypic	phenotypic	JJ
cord-015684-q10sx1dm	148	3	differences	difference	NNS
cord-015684-q10sx1dm	148	4	are	be	VBP
cord-015684-q10sx1dm	148	5	less	less	RBR
cord-015684-q10sx1dm	148	6	pronounced	pronounce	VBN
cord-015684-q10sx1dm	148	7	when	when	WRB
cord-015684-q10sx1dm	148	8	AD	ad	NN
cord-015684-q10sx1dm	148	9	patients	patient	NNS
cord-015684-q10sx1dm	148	10	are	be	VBP
cord-015684-q10sx1dm	148	11	classifi	classifi	NNP
cord-015684-q10sx1dm	148	12	ed	ed	NN
cord-015684-q10sx1dm	148	13	according	accord	VBG
cord-015684-q10sx1dm	148	14	to	to	IN
cord-015684-q10sx1dm	148	15	their	-PRON-	PRP$
cord-015684-q10sx1dm	148	16	PS1	PS1	NNP
cord-015684-q10sx1dm	148	17	(	(	-LRB-
cord-015684-q10sx1dm	148	18	15.6	15.6	CD
cord-015684-q10sx1dm	148	19	%	%	NN
cord-015684-q10sx1dm	148	20	)	)	-RRB-
cord-015684-q10sx1dm	148	21	or	or	CC
cord-015684-q10sx1dm	148	22	ACE	ace	NN
cord-015684-q10sx1dm	148	23	genotypes	genotype	NNS
cord-015684-q10sx1dm	148	24	(	(	-LRB-
cord-015684-q10sx1dm	148	25	23.52	23.52	CD
cord-015684-q10sx1dm	148	26	%	%	NN
cord-015684-q10sx1dm	148	27	)	)	-RRB-
cord-015684-q10sx1dm	148	28	,	,	,
cord-015684-q10sx1dm	148	29	refl	refl	NNP
cord-015684-q10sx1dm	148	30	ecting	ecte	VBG
cord-015684-q10sx1dm	148	31	a	a	DT
cord-015684-q10sx1dm	148	32	weak	weak	JJ
cord-015684-q10sx1dm	148	33	impact	impact	NN
cord-015684-q10sx1dm	148	34	of	of	IN
cord-015684-q10sx1dm	148	35	PS1-and	PS1-and	NNP
cord-015684-q10sx1dm	148	36	ACE	ace	NN
cord-015684-q10sx1dm	148	37	-	-	HYPH
cord-015684-q10sx1dm	148	38	related	relate	VBN
cord-015684-q10sx1dm	148	39	genotypes	genotype	NNS
cord-015684-q10sx1dm	148	40	on	on	IN
cord-015684-q10sx1dm	148	41	the	the	DT
cord-015684-q10sx1dm	148	42	phenotypic	phenotypic	JJ
cord-015684-q10sx1dm	148	43	expression	expression	NN
cord-015684-q10sx1dm	148	44	of	of	IN
cord-015684-q10sx1dm	148	45	biological	biological	JJ
cord-015684-q10sx1dm	148	46	markers	marker	NNS
cord-015684-q10sx1dm	148	47	in	in	IN
cord-015684-q10sx1dm	148	48	AD	ad	NN
cord-015684-q10sx1dm	148	49	.	.	.
cord-015684-q10sx1dm	149	1	PS1related	ps1related	JJ
cord-015684-q10sx1dm	149	2	genotypes	genotype	NNS
cord-015684-q10sx1dm	149	3	appear	appear	VBP
cord-015684-q10sx1dm	149	4	to	to	IN
cord-015684-q10sx1dm	149	5	infl	infl	NN
cord-015684-q10sx1dm	149	6	uence	uence	NN
cord-015684-q10sx1dm	149	7	age	age	NN
cord-015684-q10sx1dm	149	8	of	of	IN
cord-015684-q10sx1dm	149	9	onset	onset	NN
cord-015684-q10sx1dm	149	10	,	,	,
cord-015684-q10sx1dm	149	11	blood	blood	NN
cord-015684-q10sx1dm	149	12	histamine	histamine	NN
cord-015684-q10sx1dm	149	13	levels	level	NNS
cord-015684-q10sx1dm	149	14	and	and	CC
cord-015684-q10sx1dm	149	15	cerebrovascular	cerebrovascular	JJ
cord-015684-q10sx1dm	149	16	hemodynamics	hemodynamic	NNS
cord-015684-q10sx1dm	149	17	,	,	,
cord-015684-q10sx1dm	149	18	as	as	IN
cord-015684-q10sx1dm	149	19	refl	refl	NNP
cord-015684-q10sx1dm	149	20	ected	ecte	VBN
cord-015684-q10sx1dm	149	21	by	by	IN
cord-015684-q10sx1dm	149	22	signifi	signifi	NNP
cord-015684-q10sx1dm	149	23	ca	can	MD
cord-015684-q10sx1dm	149	24	nt	not	RB
cord-015684-q10sx1dm	149	25	changes	change	NNS
cord-015684-q10sx1dm	149	26	in	in	IN
cord-015684-q10sx1dm	149	27	systolic	systolic	JJ
cord-015684-q10sx1dm	149	28	(	(	-LRB-
cord-015684-q10sx1dm	149	29	Sv	Sv	NNP
cord-015684-q10sx1dm	149	30	)	)	-RRB-
cord-015684-q10sx1dm	149	31	,	,	,
cord-015684-q10sx1dm	149	32	diastolic	diastolic	JJ
cord-015684-q10sx1dm	149	33	(	(	-LRB-
cord-015684-q10sx1dm	149	34	Dv	Dv	NNP
cord-015684-q10sx1dm	149	35	)	)	-RRB-
cord-015684-q10sx1dm	149	36	,	,	,
cord-015684-q10sx1dm	149	37	and	and	CC
cord-015684-q10sx1dm	149	38	mean	mean	JJ
cord-015684-q10sx1dm	149	39	velocities	velocity	NNS
cord-015684-q10sx1dm	149	40	(	(	-LRB-
cord-015684-q10sx1dm	149	41	Mv	Mv	NNP
cord-015684-q10sx1dm	149	42	)	)	-RRB-
cord-015684-q10sx1dm	149	43	in	in	IN
cord-015684-q10sx1dm	149	44	the	the	DT
cord-015684-q10sx1dm	149	45	left	left	JJ
cord-015684-q10sx1dm	149	46	middle	middle	JJ
cord-015684-q10sx1dm	149	47	cerebral	cerebral	JJ
cord-015684-q10sx1dm	149	48	arteries	artery	NNS
cord-015684-q10sx1dm	149	49	(	(	-LRB-
cord-015684-q10sx1dm	149	50	MCA	MCA	NNP
cord-015684-q10sx1dm	149	51	)	)	-RRB-
cord-015684-q10sx1dm	149	52	.	.	.
cord-015684-q10sx1dm	150	1	19	19	CD
cord-015684-q10sx1dm	150	2	ACE	ace	NN
cord-015684-q10sx1dm	150	3	-	-	HYPH
cord-015684-q10sx1dm	150	4	related	relate	VBN
cord-015684-q10sx1dm	150	5	phenotypes	phenotype	NNS
cord-015684-q10sx1dm	150	6	seem	seem	VBP
cord-015684-q10sx1dm	150	7	to	to	TO
cord-015684-q10sx1dm	150	8	be	be	VB
cord-015684-q10sx1dm	150	9	more	more	RBR
cord-015684-q10sx1dm	150	10	infl	infl	NN
cord-015684-q10sx1dm	150	11	uential	uential	NN
cord-015684-q10sx1dm	150	12	than	than	IN
cord-015684-q10sx1dm	150	13	PS1	PS1	NNP
cord-015684-q10sx1dm	150	14	genotypes	genotype	NNS
cord-015684-q10sx1dm	150	15	in	in	IN
cord-015684-q10sx1dm	150	16	defi	defi	NNP
cord-015684-q10sx1dm	150	17	ning	ning	NNP
cord-015684-q10sx1dm	150	18	biological	biological	JJ
cord-015684-q10sx1dm	150	19	phenotypes	phenotype	NNS
cord-015684-q10sx1dm	150	20	,	,	,
cord-015684-q10sx1dm	150	21	such	such	JJ
cord-015684-q10sx1dm	150	22	as	as	IN
cord-015684-q10sx1dm	150	23	age	age	NN
cord-015684-q10sx1dm	150	24	of	of	IN
cord-015684-q10sx1dm	150	25	onset	onset	NN
cord-015684-q10sx1dm	150	26	,	,	,
cord-015684-q10sx1dm	150	27	cognitive	cognitive	JJ
cord-015684-q10sx1dm	150	28	performance	performance	NN
cord-015684-q10sx1dm	150	29	,	,	,
cord-015684-q10sx1dm	150	30	HDL	HDL	NNP
cord-015684-q10sx1dm	150	31	-	-	HYPH
cord-015684-q10sx1dm	150	32	CHO	CHO	NNP
cord-015684-q10sx1dm	150	33	levels	level	NNS
cord-015684-q10sx1dm	150	34	,	,	,
cord-015684-q10sx1dm	150	35	ACE	ace	NN
cord-015684-q10sx1dm	150	36	and	and	CC
cord-015684-q10sx1dm	150	37	NO	no	DT
cord-015684-q10sx1dm	150	38	levels	level	NNS
cord-015684-q10sx1dm	150	39	,	,	,
cord-015684-q10sx1dm	150	40	and	and	CC
cord-015684-q10sx1dm	150	41	brain	brain	NN
cord-015684-q10sx1dm	150	42	blood	blood	NN
cord-015684-q10sx1dm	150	43	fl	fl	NNP
cord-015684-q10sx1dm	150	44	ow	ow	NNP
cord-015684-q10sx1dm	150	45	Mv	Mv	NNP
cord-015684-q10sx1dm	150	46	in	in	IN
cord-015684-q10sx1dm	150	47	MCA	MCA	NNP
cord-015684-q10sx1dm	150	48	.	.	.
cord-015684-q10sx1dm	151	1	However	however	RB
cord-015684-q10sx1dm	151	2	,	,	,
cord-015684-q10sx1dm	151	3	when	when	WRB
cord-015684-q10sx1dm	151	4	APOE	APOE	NNP
cord-015684-q10sx1dm	151	5	and	and	CC
cord-015684-q10sx1dm	151	6	PS1	PS1	NNP
cord-015684-q10sx1dm	151	7	genotypes	genotype	NNS
cord-015684-q10sx1dm	151	8	are	be	VBP
cord-015684-q10sx1dm	151	9	integrated	integrate	VBN
cord-015684-q10sx1dm	151	10	in	in	IN
cord-015684-q10sx1dm	151	11	bigenic	bigenic	JJ
cord-015684-q10sx1dm	151	12	clusters	cluster	NNS
cord-015684-q10sx1dm	151	13	and	and	CC
cord-015684-q10sx1dm	151	14	the	the	DT
cord-015684-q10sx1dm	151	15	resulting	result	VBG
cord-015684-q10sx1dm	151	16	bigenic	bigenic	JJ
cord-015684-q10sx1dm	151	17	genotypes	genotype	NNS
cord-015684-q10sx1dm	151	18	are	be	VBP
cord-015684-q10sx1dm	151	19	differentiated	differentiate	VBN
cord-015684-q10sx1dm	151	20	according	accord	VBG
cord-015684-q10sx1dm	151	21	to	to	IN
cord-015684-q10sx1dm	151	22	their	-PRON-	PRP$
cord-015684-q10sx1dm	151	23	corresponding	corresponding	JJ
cord-015684-q10sx1dm	151	24	phenotypes	phenotype	NNS
cord-015684-q10sx1dm	151	25	,	,	,
cord-015684-q10sx1dm	151	26	an	an	DT
cord-015684-q10sx1dm	151	27	almost	almost	RB
cord-015684-q10sx1dm	151	28	logarithmic	logarithmic	JJ
cord-015684-q10sx1dm	151	29	increased	increase	VBN
cord-015684-q10sx1dm	151	30	expression	expression	NN
cord-015684-q10sx1dm	151	31	of	of	IN
cord-015684-q10sx1dm	151	32	differential	differential	JJ
cord-015684-q10sx1dm	151	33	phenotypes	phenotype	NNS
cord-015684-q10sx1dm	151	34	is	be	VBZ
cord-015684-q10sx1dm	151	35	observed	observe	VBN
cord-015684-q10sx1dm	151	36	(	(	-LRB-
cord-015684-q10sx1dm	151	37	61.46	61.46	CD
cord-015684-q10sx1dm	151	38	%	%	NN
cord-015684-q10sx1dm	151	39	variation	variation	NN
cord-015684-q10sx1dm	151	40	)	)	-RRB-
cord-015684-q10sx1dm	151	41	,	,	,
cord-015684-q10sx1dm	151	42	indicating	indicate	VBG
cord-015684-q10sx1dm	151	43	the	the	DT
cord-015684-q10sx1dm	151	44	existence	existence	NN
cord-015684-q10sx1dm	151	45	of	of	IN
cord-015684-q10sx1dm	151	46	a	a	DT
cord-015684-q10sx1dm	151	47	synergistic	synergistic	JJ
cord-015684-q10sx1dm	151	48	effect	effect	NN
cord-015684-q10sx1dm	151	49	of	of	IN
cord-015684-q10sx1dm	151	50	the	the	DT
cord-015684-q10sx1dm	151	51	bigenic	bigenic	JJ
cord-015684-q10sx1dm	151	52	(	(	-LRB-
cord-015684-q10sx1dm	151	53	APOE	APOE	NNP
cord-015684-q10sx1dm	151	54	+	+	SYM
cord-015684-q10sx1dm	151	55	PS1	PS1	NNP
cord-015684-q10sx1dm	151	56	)	)	-RRB-
cord-015684-q10sx1dm	151	57	cluster	cluster	NN
cord-015684-q10sx1dm	151	58	on	on	IN
cord-015684-q10sx1dm	151	59	the	the	DT
cord-015684-q10sx1dm	151	60	expression	expression	NN
cord-015684-q10sx1dm	151	61	of	of	IN
cord-015684-q10sx1dm	151	62	biological	biological	JJ
cord-015684-q10sx1dm	151	63	markers	marker	NNS
cord-015684-q10sx1dm	151	64	,	,	,
cord-015684-q10sx1dm	151	65	apparently	apparently	RB
cord-015684-q10sx1dm	151	66	unrelated	unrelated	JJ
cord-015684-q10sx1dm	151	67	to	to	IN
cord-015684-q10sx1dm	151	68	APP	app	NN
cord-015684-q10sx1dm	151	69	/	/	SYM
cord-015684-q10sx1dm	151	70	PS1	ps1	NN
cord-015684-q10sx1dm	151	71	mutations	mutation	NNS
cord-015684-q10sx1dm	151	72	,	,	,
cord-015684-q10sx1dm	151	73	since	since	IN
cord-015684-q10sx1dm	151	74	none	none	NN
cord-015684-q10sx1dm	151	75	of	of	IN
cord-015684-q10sx1dm	151	76	the	the	DT
cord-015684-q10sx1dm	151	77	patients	patient	NNS
cord-015684-q10sx1dm	151	78	included	include	VBN
cord-015684-q10sx1dm	151	79	in	in	IN
cord-015684-q10sx1dm	151	80	the	the	DT
cord-015684-q10sx1dm	151	81	sample	sample	NN
cord-015684-q10sx1dm	151	82	were	be	VBD
cord-015684-q10sx1dm	151	83	carriers	carrier	NNS
cord-015684-q10sx1dm	151	84	of	of	IN
cord-015684-q10sx1dm	151	85	either	either	DT
cord-015684-q10sx1dm	151	86	APP	app	NN
cord-015684-q10sx1dm	151	87	or	or	CC
cord-015684-q10sx1dm	151	88	PS1	PS1	NNP
cord-015684-q10sx1dm	151	89	mutations	mutation	NNS
cord-015684-q10sx1dm	151	90	.	.	.
cord-015684-q10sx1dm	152	1	19	19	CD
cord-015684-q10sx1dm	152	2	,	,	,
cord-015684-q10sx1dm	152	3	61	61	CD
cord-015684-q10sx1dm	152	4	,	,	,
cord-015684-q10sx1dm	152	5	62	62	CD
cord-015684-q10sx1dm	153	1	These	these	DT
cord-015684-q10sx1dm	153	2	examples	example	NNS
cord-015684-q10sx1dm	153	3	illustrate	illustrate	VBP
cord-015684-q10sx1dm	153	4	the	the	DT
cord-015684-q10sx1dm	153	5	potential	potential	JJ
cord-015684-q10sx1dm	153	6	additive	additive	NN
cord-015684-q10sx1dm	153	7	effects	effect	NNS
cord-015684-q10sx1dm	153	8	of	of	IN
cord-015684-q10sx1dm	153	9	AD	ad	NN
cord-015684-q10sx1dm	153	10	-	-	HYPH
cord-015684-q10sx1dm	153	11	related	relate	VBN
cord-015684-q10sx1dm	153	12	genes	gene	NNS
cord-015684-q10sx1dm	153	13	on	on	IN
cord-015684-q10sx1dm	153	14	the	the	DT
cord-015684-q10sx1dm	153	15	phenotypic	phenotypic	JJ
cord-015684-q10sx1dm	153	16	expression	expression	NN
cord-015684-q10sx1dm	153	17	of	of	IN
cord-015684-q10sx1dm	153	18	biological	biological	JJ
cord-015684-q10sx1dm	153	19	markers	marker	NNS
cord-015684-q10sx1dm	153	20	.	.	.
cord-015684-q10sx1dm	154	1	Furthermore	furthermore	RB
cord-015684-q10sx1dm	154	2	,	,	,
cord-015684-q10sx1dm	154	3	the	the	DT
cord-015684-q10sx1dm	154	4	analysis	analysis	NN
cord-015684-q10sx1dm	154	5	of	of	IN
cord-015684-q10sx1dm	154	6	genotype	genotype	NN
cord-015684-q10sx1dm	154	7	-	-	HYPH
cord-015684-q10sx1dm	154	8	phenotype	phenotype	NN
cord-015684-q10sx1dm	154	9	correlations	correlation	NNS
cord-015684-q10sx1dm	154	10	with	with	IN
cord-015684-q10sx1dm	154	11	a	a	DT
cord-015684-q10sx1dm	154	12	monogenic	monogenic	NNP
cord-015684-q10sx1dm	154	13	or	or	CC
cord-015684-q10sx1dm	154	14	bigenic	bigenic	NNP
cord-015684-q10sx1dm	154	15	approach	approach	NN
cord-015684-q10sx1dm	154	16	documents	document	VBZ
cord-015684-q10sx1dm	154	17	a	a	DT
cord-015684-q10sx1dm	154	18	modest	modest	JJ
cord-015684-q10sx1dm	154	19	genotype	genotype	NN
cord-015684-q10sx1dm	154	20	-	-	HYPH
cord-015684-q10sx1dm	154	21	related	relate	VBN
cord-015684-q10sx1dm	154	22	variation	variation	NN
cord-015684-q10sx1dm	154	23	in	in	IN
cord-015684-q10sx1dm	154	24	serum	serum	NN
cord-015684-q10sx1dm	154	25	amyloid	amyloid	NN
cord-015684-q10sx1dm	154	26	-	-	HYPH
cord-015684-q10sx1dm	154	27	β	β	NN
cord-015684-q10sx1dm	154	28	(	(	-LRB-
cord-015684-q10sx1dm	154	29	ABP	ABP	NNP
cord-015684-q10sx1dm	154	30	)	)	-RRB-
cord-015684-q10sx1dm	154	31	levels	level	NNS
cord-015684-q10sx1dm	154	32	,	,	,
cord-015684-q10sx1dm	154	33	suggesting	suggest	VBG
cord-015684-q10sx1dm	154	34	that	that	IN
cord-015684-q10sx1dm	154	35	peripheral	peripheral	JJ
cord-015684-q10sx1dm	154	36	levels	level	NNS
cord-015684-q10sx1dm	154	37	of	of	IN
cord-015684-q10sx1dm	154	38	ABP	ABP	NNP
cord-015684-q10sx1dm	154	39	are	be	VBP
cord-015684-q10sx1dm	154	40	of	of	IN
cord-015684-q10sx1dm	154	41	relative	relative	JJ
cord-015684-q10sx1dm	154	42	value	value	NN
cord-015684-q10sx1dm	154	43	as	as	IN
cord-015684-q10sx1dm	154	44	predictors	predictor	NNS
cord-015684-q10sx1dm	154	45	of	of	IN
cord-015684-q10sx1dm	154	46	disease	disease	NN
cord-015684-q10sx1dm	154	47	-	-	HYPH
cord-015684-q10sx1dm	154	48	stage	stage	NN
cord-015684-q10sx1dm	154	49	or	or	CC
cord-015684-q10sx1dm	154	50	as	as	IN
cord-015684-q10sx1dm	154	51	markers	marker	NNS
cord-015684-q10sx1dm	154	52	of	of	IN
cord-015684-q10sx1dm	154	53	disease	disease	NN
cord-015684-q10sx1dm	154	54	progression	progression	NN
cord-015684-q10sx1dm	154	55	and/	and/	NNP
cord-015684-q10sx1dm	154	56	or	or	CC
cord-015684-q10sx1dm	154	57	treatment	treatment	NN
cord-015684-q10sx1dm	154	58	-	-	HYPH
cord-015684-q10sx1dm	154	59	related	relate	VBN
cord-015684-q10sx1dm	154	60	disease	disease	NN
cord-015684-q10sx1dm	154	61	-	-	HYPH
cord-015684-q10sx1dm	154	62	modifying	modify	VBG
cord-015684-q10sx1dm	154	63	effects	effect	NNS
cord-015684-q10sx1dm	154	64	.	.	.
cord-015684-q10sx1dm	155	1	19	19	CD
cord-015684-q10sx1dm	155	2	,	,	,
cord-015684-q10sx1dm	155	3	61	61	CD
cord-015684-q10sx1dm	155	4	,	,	,
cord-015684-q10sx1dm	155	5	62	62	CD
cord-015684-q10sx1dm	156	1	The	the	DT
cord-015684-q10sx1dm	156	2	peripheral	peripheral	JJ
cord-015684-q10sx1dm	156	3	levels	level	NNS
cord-015684-q10sx1dm	156	4	of	of	IN
cord-015684-q10sx1dm	156	5	ABP	ABP	NNP
cord-015684-q10sx1dm	156	6	in	in	IN
cord-015684-q10sx1dm	156	7	serum	serum	NN
cord-015684-q10sx1dm	156	8	exhibit	exhibit	NN
cord-015684-q10sx1dm	156	9	an	an	DT
cord-015684-q10sx1dm	156	10	APOE	APOE	NNP
cord-015684-q10sx1dm	156	11	-	-	HYPH
cord-015684-q10sx1dm	156	12	dependent	dependent	JJ
cord-015684-q10sx1dm	156	13	pattern	pattern	NN
cord-015684-q10sx1dm	156	14	according	accord	VBG
cord-015684-q10sx1dm	156	15	to	to	IN
cord-015684-q10sx1dm	156	16	which	which	WDT
cord-015684-q10sx1dm	156	17	both	both	DT
cord-015684-q10sx1dm	156	18	APOE-4(+	apoe-4(+	XX
cord-015684-q10sx1dm	156	19	)	)	-RRB-
cord-015684-q10sx1dm	156	20	and	and	CC
cord-015684-q10sx1dm	156	21	APOE-2(+	apoe-2(+	JJ
cord-015684-q10sx1dm	156	22	)	)	-RRB-
cord-015684-q10sx1dm	156	23	carriers	carrier	NNS
cord-015684-q10sx1dm	156	24	tend	tend	VBP
cord-015684-q10sx1dm	156	25	to	to	TO
cord-015684-q10sx1dm	156	26	show	show	VB
cord-015684-q10sx1dm	156	27	higher	high	JJR
cord-015684-q10sx1dm	156	28	ABP	ABP	NNP
cord-015684-q10sx1dm	156	29	levels	level	NNS
cord-015684-q10sx1dm	156	30	than	than	IN
cord-015684-q10sx1dm	156	31	APOE-4(−	APOE-4(−	NNP
cord-015684-q10sx1dm	156	32	)	)	-RRB-
cord-015684-q10sx1dm	156	33	or	or	CC
cord-015684-q10sx1dm	156	34	APOE-3	APOE-3	NNP
cord-015684-q10sx1dm	156	35	carriers	carrier	NNS
cord-015684-q10sx1dm	157	1	19,61	19,61	CD
cord-015684-q10sx1dm	157	2	-	-	SYM
cord-015684-q10sx1dm	157	3	63	63	CD
cord-015684-q10sx1dm	158	1	(	(	-LRB-
cord-015684-q10sx1dm	158	2	Fig	Fig	NNP
cord-015684-q10sx1dm	158	3	.	.	.
cord-015684-q10sx1dm	158	4	40	40	CD
cord-015684-q10sx1dm	158	5	est	est	NN
cord-015684-q10sx1dm	158	6	concentration	concentration	NN
cord-015684-q10sx1dm	158	7	of	of	IN
cord-015684-q10sx1dm	158	8	serum	serum	NN
cord-015684-q10sx1dm	158	9	histamine	histamine	NN
cord-015684-q10sx1dm	158	10	is	be	VBZ
cord-015684-q10sx1dm	158	11	systematically	systematically	RB
cord-015684-q10sx1dm	158	12	present	present	JJ
cord-015684-q10sx1dm	158	13	in	in	IN
cord-015684-q10sx1dm	158	14	APOE-2(+	apoe-2(+	$
cord-015684-q10sx1dm	158	15	)	)	-RRB-
cord-015684-q10sx1dm	159	1	and	and	CC
cord-015684-q10sx1dm	159	2	APOE-4(+	APOE-4(+	NNP
cord-015684-q10sx1dm	159	3	)	)	-RRB-
cord-015684-q10sx1dm	159	4	carriers	carrier	NNS
cord-015684-q10sx1dm	159	5	,	,	,
cord-015684-q10sx1dm	159	6	and	and	CC
cord-015684-q10sx1dm	159	7	the	the	DT
cord-015684-q10sx1dm	159	8	highest	high	JJS
cord-015684-q10sx1dm	159	9	levels	level	NNS
cord-015684-q10sx1dm	159	10	of	of	IN
cord-015684-q10sx1dm	159	11	histamine	histamine	NN
cord-015684-q10sx1dm	159	12	are	be	VBP
cord-015684-q10sx1dm	159	13	seen	see	VBN
cord-015684-q10sx1dm	159	14	in	in	IN
cord-015684-q10sx1dm	159	15	APOE-3(+	APOE-3(+	NNP
cord-015684-q10sx1dm	159	16	)	)	-RRB-
cord-015684-q10sx1dm	159	17	carriers	carrier	NNS
cord-015684-q10sx1dm	159	18	(	(	-LRB-
cord-015684-q10sx1dm	159	19	Fig	Fig	NNP
cord-015684-q10sx1dm	159	20	.	.	.
cord-015684-q10sx1dm	159	21	40.3	40.3	CD
cord-015684-q10sx1dm	159	22	)	)	-RRB-
cord-015684-q10sx1dm	159	23	.	.	.
cord-015684-q10sx1dm	160	1	Central	central	JJ
cord-015684-q10sx1dm	160	2	and	and	CC
cord-015684-q10sx1dm	160	3	peripheral	peripheral	JJ
cord-015684-q10sx1dm	160	4	histaminergic	histaminergic	JJ
cord-015684-q10sx1dm	160	5	mechanisms	mechanism	NNS
cord-015684-q10sx1dm	160	6	may	may	MD
cord-015684-q10sx1dm	160	7	regulate	regulate	VB
cord-015684-q10sx1dm	160	8	cerebrovascular	cerebrovascular	JJ
cord-015684-q10sx1dm	160	9	function	function	NN
cord-015684-q10sx1dm	160	10	in	in	IN
cord-015684-q10sx1dm	160	11	AD	ad	NN
cord-015684-q10sx1dm	160	12	,	,	,
cord-015684-q10sx1dm	160	13	which	which	WDT
cord-015684-q10sx1dm	160	14	is	be	VBZ
cord-015684-q10sx1dm	160	15	signifi	signifi	NNP
cord-015684-q10sx1dm	160	16	cantly	cantly	RB
cord-015684-q10sx1dm	160	17	altered	alter	VBN
cord-015684-q10sx1dm	160	18	in	in	IN
cord-015684-q10sx1dm	160	19	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	160	20	carriers	carrier	NNS
cord-015684-q10sx1dm	160	21	.	.	.
cord-015684-q10sx1dm	161	1	19	19	CD
cord-015684-q10sx1dm	161	2	,	,	,
cord-015684-q10sx1dm	161	3	[	[	-LRB-
cord-015684-q10sx1dm	161	4	61	61	CD
cord-015684-q10sx1dm	161	5	]	]	-RRB-
cord-015684-q10sx1dm	161	6	[	[	-LRB-
cord-015684-q10sx1dm	161	7	62	62	CD
cord-015684-q10sx1dm	161	8	]	]	-RRB-
cord-015684-q10sx1dm	161	9	[	[	-LRB-
cord-015684-q10sx1dm	161	10	63	63	CD
cord-015684-q10sx1dm	161	11	]	]	-RRB-
cord-015684-q10sx1dm	162	1	[	[	-LRB-
cord-015684-q10sx1dm	162	2	64	64	CD
cord-015684-q10sx1dm	162	3	]	]	-RRB-
cord-015684-q10sx1dm	163	1	[	[	-LRB-
cord-015684-q10sx1dm	163	2	65	65	CD
cord-015684-q10sx1dm	163	3	]	]	-RRB-
cord-015684-q10sx1dm	164	1	[	[	-LRB-
cord-015684-q10sx1dm	164	2	66	66	CD
cord-015684-q10sx1dm	164	3	]	]	-RRB-
cord-015684-q10sx1dm	165	1	These	these	DT
cord-015684-q10sx1dm	165	2	observations	observation	NNS
cord-015684-q10sx1dm	165	3	can	can	MD
cord-015684-q10sx1dm	165	4	lead	lead	VB
cord-015684-q10sx1dm	165	5	to	to	IN
cord-015684-q10sx1dm	165	6	the	the	DT
cord-015684-q10sx1dm	165	7	conclusion	conclusion	NN
cord-015684-q10sx1dm	165	8	that	that	IN
cord-015684-q10sx1dm	165	9	the	the	DT
cord-015684-q10sx1dm	165	10	simple	simple	JJ
cord-015684-q10sx1dm	165	11	quantifi	quantifi	NN
cord-015684-q10sx1dm	165	12	cation	cation	NN
cord-015684-q10sx1dm	165	13	of	of	IN
cord-015684-q10sx1dm	165	14	biochemical	biochemical	JJ
cord-015684-q10sx1dm	165	15	markers	marker	NNS
cord-015684-q10sx1dm	165	16	in	in	IN
cord-015684-q10sx1dm	165	17	fl	fl	NNP
cord-015684-q10sx1dm	165	18	uids	uid	NNS
cord-015684-q10sx1dm	165	19	or	or	CC
cord-015684-q10sx1dm	165	20	tissues	tissue	NNS
cord-015684-q10sx1dm	165	21	of	of	IN
cord-015684-q10sx1dm	165	22	AD	ad	NN
cord-015684-q10sx1dm	165	23	patients	patient	NNS
cord-015684-q10sx1dm	165	24	with	with	IN
cord-015684-q10sx1dm	165	25	the	the	DT
cord-015684-q10sx1dm	165	26	aim	aim	NN
cord-015684-q10sx1dm	165	27	of	of	IN
cord-015684-q10sx1dm	165	28	identifying	identify	VBG
cord-015684-q10sx1dm	165	29	pathogenic	pathogenic	JJ
cord-015684-q10sx1dm	165	30	mechanisms	mechanism	NNS
cord-015684-q10sx1dm	165	31	and/or	and/or	CC
cord-015684-q10sx1dm	165	32	monitoring	monitor	VBG
cord-015684-q10sx1dm	165	33	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	165	34	effects	effect	NNS
cord-015684-q10sx1dm	165	35	,	,	,
cord-015684-q10sx1dm	165	36	when	when	WRB
cord-015684-q10sx1dm	165	37	they	-PRON-	PRP
cord-015684-q10sx1dm	165	38	are	be	VBP
cord-015684-q10sx1dm	165	39	not	not	RB
cord-015684-q10sx1dm	165	40	accompanied	accompany	VBN
cord-015684-q10sx1dm	165	41	by	by	IN
cord-015684-q10sx1dm	165	42	differential	differential	JJ
cord-015684-q10sx1dm	165	43	genotyping	genotyping	NN
cord-015684-q10sx1dm	165	44	for	for	IN
cord-015684-q10sx1dm	165	45	sample	sample	NN
cord-015684-q10sx1dm	165	46	homogenization	homogenization	NN
cord-015684-q10sx1dm	165	47	,	,	,
cord-015684-q10sx1dm	165	48	are	be	VBP
cord-015684-q10sx1dm	165	49	of	of	IN
cord-015684-q10sx1dm	165	50	very	very	RB
cord-015684-q10sx1dm	165	51	poor	poor	JJ
cord-015684-q10sx1dm	165	52	value	value	NN
cord-015684-q10sx1dm	165	53	.	.	.
cord-015684-q10sx1dm	166	1	Differential	differential	JJ
cord-015684-q10sx1dm	166	2	patterns	pattern	NNS
cord-015684-q10sx1dm	166	3	of	of	IN
cord-015684-q10sx1dm	166	4	APOE-	apoe-	RB
cord-015684-q10sx1dm	166	5	,	,	,
cord-015684-q10sx1dm	166	6	PS1-	PS1-	NNP
cord-015684-q10sx1dm	166	7	,	,	,
cord-015684-q10sx1dm	166	8	PS2-	PS2-	NNP
cord-015684-q10sx1dm	166	9	,	,	,
cord-015684-q10sx1dm	166	10	and	and	CC
cord-015684-q10sx1dm	166	11	trigenic	trigenic	JJ
cord-015684-q10sx1dm	166	12	(	(	-LRB-
cord-015684-q10sx1dm	166	13	APOE	APOE	NNP
cord-015684-q10sx1dm	166	14	+	+	SYM
cord-015684-q10sx1dm	166	15	PS1	PS1	NNP
cord-015684-q10sx1dm	166	16	+	+	CC
cord-015684-q10sx1dm	166	17	PS2	PS2	NNP
cord-015684-q10sx1dm	166	18	)	)	-RRB-
cord-015684-q10sx1dm	166	19	cluster	cluster	NN
cord-015684-q10sx1dm	166	20	-	-	HYPH
cord-015684-q10sx1dm	166	21	related	relate	VBN
cord-015684-q10sx1dm	166	22	lymphocyte	lymphocyte	NN
cord-015684-q10sx1dm	166	23	apoptosis	apoptosis	NN
cord-015684-q10sx1dm	166	24	have	have	VBP
cord-015684-q10sx1dm	166	25	been	be	VBN
cord-015684-q10sx1dm	166	26	detected	detect	VBN
cord-015684-q10sx1dm	166	27	in	in	IN
cord-015684-q10sx1dm	166	28	AD	ad	NN
cord-015684-q10sx1dm	166	29	.	.	.
cord-015684-q10sx1dm	167	1	Fas	Fas	NNP
cord-015684-q10sx1dm	167	2	receptor	receptor	NN
cord-015684-q10sx1dm	167	3	expression	expression	NN
cord-015684-q10sx1dm	167	4	is	be	VBZ
cord-015684-q10sx1dm	167	5	signifi	signifi	NNP
cord-015684-q10sx1dm	167	6	cantly	cantly	RB
cord-015684-q10sx1dm	167	7	increased	increase	VBN
cord-015684-q10sx1dm	167	8	in	in	IN
cord-015684-q10sx1dm	167	9	AD	ad	NN
cord-015684-q10sx1dm	167	10	,	,	,
cord-015684-q10sx1dm	167	11	especially	especially	RB
cord-015684-q10sx1dm	167	12	in	in	IN
cord-015684-q10sx1dm	167	13	APOE-4	APOE-4	NNP
cord-015684-q10sx1dm	167	14	carriers	carrier	NNS
cord-015684-q10sx1dm	167	15	where	where	WRB
cord-015684-q10sx1dm	167	16	lymphocyte	lymphocyte	NN
cord-015684-q10sx1dm	167	17	apoptosis	apoptosis	NN
cord-015684-q10sx1dm	167	18	is	be	VBZ
cord-015684-q10sx1dm	167	19	more	more	RBR
cord-015684-q10sx1dm	167	20	relevant	relevant	JJ
cord-015684-q10sx1dm	167	21	.	.	.
cord-015684-q10sx1dm	168	1	19	19	CD
cord-015684-q10sx1dm	168	2	,	,	,
cord-015684-q10sx1dm	168	3	67	67	CD
cord-015684-q10sx1dm	169	1	It	-PRON-	PRP
cord-015684-q10sx1dm	169	2	has	have	VBZ
cord-015684-q10sx1dm	169	3	been	be	VBN
cord-015684-q10sx1dm	169	4	demonstrated	demonstrate	VBN
cord-015684-q10sx1dm	169	5	that	that	IN
cord-015684-q10sx1dm	169	6	brain	brain	NN
cord-015684-q10sx1dm	169	7	activity	activity	NN
cord-015684-q10sx1dm	169	8	slowing	slowing	NN
cord-015684-q10sx1dm	169	9	correlates	correlate	VBZ
cord-015684-q10sx1dm	169	10	with	with	IN
cord-015684-q10sx1dm	169	11	progressive	progressive	JJ
cord-015684-q10sx1dm	169	12	GDS	GDS	NNP
cord-015684-q10sx1dm	169	13	staging	staging	NN
cord-015684-q10sx1dm	169	14	in	in	IN
cord-015684-q10sx1dm	169	15	dementia	dementia	NN
cord-015684-q10sx1dm	169	16	8	8	CD
cord-015684-q10sx1dm	169	17	,	,	,
cord-015684-q10sx1dm	169	18	16	16	CD
cord-015684-q10sx1dm	169	19	,	,	,
cord-015684-q10sx1dm	169	20	[	[	-LRB-
cord-015684-q10sx1dm	169	21	18	18	CD
cord-015684-q10sx1dm	169	22	]	]	-RRB-
cord-015684-q10sx1dm	169	23	[	[	-LRB-
cord-015684-q10sx1dm	169	24	19	19	CD
cord-015684-q10sx1dm	169	25	]	]	-RRB-
cord-015684-q10sx1dm	169	26	[	[	-LRB-
cord-015684-q10sx1dm	169	27	20	20	CD
cord-015684-q10sx1dm	169	28	]	]	-RRB-
cord-015684-q10sx1dm	169	29	(	(	-LRB-
cord-015684-q10sx1dm	170	1	Fig	Fig	NNP
cord-015684-q10sx1dm	170	2	.	.	.
cord-015684-q10sx1dm	170	3	40.4	40.4	CD
cord-015684-q10sx1dm	170	4	)	)	-RRB-
cord-015684-q10sx1dm	170	5	.	.	.
cord-015684-q10sx1dm	171	1	In	in	IN
cord-015684-q10sx1dm	171	2	the	the	DT
cord-015684-q10sx1dm	171	3	general	general	JJ
cord-015684-q10sx1dm	171	4	population	population	NN
cord-015684-q10sx1dm	171	5	subjects	subject	NNS
cord-015684-q10sx1dm	171	6	harbouring	harbour	VBG
cord-015684-q10sx1dm	171	7	the	the	DT
cord-015684-q10sx1dm	171	8	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	171	9	genotype	genotype	NN
cord-015684-q10sx1dm	171	10	exhibit	exhibit	NN
cord-015684-q10sx1dm	171	11	a	a	DT
cord-015684-q10sx1dm	171	12	premature	premature	JJ
cord-015684-q10sx1dm	171	13	slowing	slowing	NN
cord-015684-q10sx1dm	171	14	in	in	IN
cord-015684-q10sx1dm	171	15	brain	brain	NN
cord-015684-q10sx1dm	171	16	mapping	mapping	NN
cord-015684-q10sx1dm	171	17	activity	activity	NN
cord-015684-q10sx1dm	171	18	represented	represent	VBN
cord-015684-q10sx1dm	171	19	by	by	IN
cord-015684-q10sx1dm	171	20	increased	increase	VBN
cord-015684-q10sx1dm	171	21	slow	slow	JJ
cord-015684-q10sx1dm	171	22	delta	delta	NN
cord-015684-q10sx1dm	171	23	and	and	CC
cord-015684-q10sx1dm	171	24	theta	theta	NN
cord-015684-q10sx1dm	171	25	activities	activity	NNS
cord-015684-q10sx1dm	171	26	as	as	IN
cord-015684-q10sx1dm	171	27	compared	compare	VBN
cord-015684-q10sx1dm	171	28	with	with	IN
cord-015684-q10sx1dm	171	29	other	other	JJ
cord-015684-q10sx1dm	171	30	APOE	APOE	NNP
cord-015684-q10sx1dm	171	31	genotypes	genotype	NNS
cord-015684-q10sx1dm	171	32	.	.	.
cord-015684-q10sx1dm	172	1	In	in	IN
cord-015684-q10sx1dm	172	2	patients	patient	NNS
cord-015684-q10sx1dm	172	3	with	with	IN
cord-015684-q10sx1dm	172	4	AD	ad	NN
cord-015684-q10sx1dm	172	5	,	,	,
cord-015684-q10sx1dm	172	6	slow	slow	JJ
cord-015684-q10sx1dm	172	7	activity	activity	NN
cord-015684-q10sx1dm	172	8	predominates	predominate	VBZ
cord-015684-q10sx1dm	172	9	in	in	IN
cord-015684-q10sx1dm	172	10	APOE-4	APOE-4	NNP
cord-015684-q10sx1dm	172	11	carriers	carrier	NNS
cord-015684-q10sx1dm	172	12	with	with	IN
cord-015684-q10sx1dm	172	13	similar	similar	JJ
cord-015684-q10sx1dm	172	14	GDS	GDS	NNP
cord-015684-q10sx1dm	172	15	stage	stage	NN
cord-015684-q10sx1dm	173	1	8,16,18	8,16,18	CD
cord-015684-q10sx1dm	173	2	-	-	SYM
cord-015684-q10sx1dm	173	3	20	20	CD
cord-015684-q10sx1dm	174	1	(	(	-LRB-
cord-015684-q10sx1dm	174	2	Fig	Fig	NNP
cord-015684-q10sx1dm	174	3	.	.	.
cord-015684-q10sx1dm	174	4	40.4	40.4	CD
cord-015684-q10sx1dm	174	5	)	)	-RRB-
cord-015684-q10sx1dm	174	6	.	.	.
cord-015684-q10sx1dm	175	1	AD	ad	NN
cord-015684-q10sx1dm	175	2	patients	patient	NNS
cord-015684-q10sx1dm	175	3	harbouring	harbour	VBG
cord-015684-q10sx1dm	175	4	the	the	DT
cord-015684-q10sx1dm	175	5	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	175	6	genotype	genotype	NN
cord-015684-q10sx1dm	175	7	also	also	RB
cord-015684-q10sx1dm	175	8	exhibit	exhibit	VBP
cord-015684-q10sx1dm	175	9	a	a	DT
cord-015684-q10sx1dm	175	10	dramatically	dramatically	RB
cord-015684-q10sx1dm	175	11	different	different	JJ
cord-015684-q10sx1dm	175	12	brain	brain	NN
cord-015684-q10sx1dm	175	13	optical	optical	JJ
cord-015684-q10sx1dm	175	14	topography	topography	NN
cord-015684-q10sx1dm	175	15	map	map	NN
cord-015684-q10sx1dm	175	16	refl	refl	NNP
cord-015684-q10sx1dm	175	17	ecting	ecte	VBG
cord-015684-q10sx1dm	175	18	a	a	DT
cord-015684-q10sx1dm	175	19	genotype	genotype	NN
cord-015684-q10sx1dm	175	20	-	-	HYPH
cord-015684-q10sx1dm	175	21	specifi	specifi	VBN
cord-015684-q10sx1dm	175	22	c	c	NN
cord-015684-q10sx1dm	175	23	differential	differential	NN
cord-015684-q10sx1dm	175	24	pattern	pattern	NN
cord-015684-q10sx1dm	175	25	of	of	IN
cord-015684-q10sx1dm	175	26	neocortical	neocortical	JJ
cord-015684-q10sx1dm	175	27	oxygenation	oxygenation	NN
cord-015684-q10sx1dm	175	28	as	as	RB
cord-015684-q10sx1dm	175	29	well	well	RB
cord-015684-q10sx1dm	175	30	as	as	IN
cord-015684-q10sx1dm	175	31	a	a	DT
cord-015684-q10sx1dm	175	32	poorer	poor	JJR
cord-015684-q10sx1dm	175	33	activation	activation	NN
cord-015684-q10sx1dm	175	34	of	of	IN
cord-015684-q10sx1dm	175	35	cortical	cortical	JJ
cord-015684-q10sx1dm	175	36	neurons	neuron	NNS
cord-015684-q10sx1dm	175	37	in	in	IN
cord-015684-q10sx1dm	175	38	response	response	NN
cord-015684-q10sx1dm	175	39	to	to	IN
cord-015684-q10sx1dm	175	40	somatosensory	somatosensory	JJ
cord-015684-q10sx1dm	175	41	stimuli	stimulus	NNS
cord-015684-q10sx1dm	175	42	(	(	-LRB-
cord-015684-q10sx1dm	175	43	Fig	Fig	NNP
cord-015684-q10sx1dm	175	44	.	.	.
cord-015684-q10sx1dm	175	45	40	40	CD
cord-015684-q10sx1dm	175	46	.5	.5	CD
cord-015684-q10sx1dm	175	47	)	)	-RRB-
cord-015684-q10sx1dm	175	48	.	.	.
cord-015684-q10sx1dm	176	1	All	all	PDT
cord-015684-q10sx1dm	176	2	these	these	DT
cord-015684-q10sx1dm	176	3	examples	example	NNS
cord-015684-q10sx1dm	176	4	of	of	IN
cord-015684-q10sx1dm	176	5	genotype	genotype	NN
cord-015684-q10sx1dm	176	6	-	-	HYPH
cord-015684-q10sx1dm	176	7	phenotype	phenotype	NN
cord-015684-q10sx1dm	176	8	correlations	correlation	NNS
cord-015684-q10sx1dm	176	9	,	,	,
cord-015684-q10sx1dm	176	10	as	as	IN
cord-015684-q10sx1dm	176	11	a	a	DT
cord-015684-q10sx1dm	176	12	gross	gross	JJ
cord-015684-q10sx1dm	176	13	approach	approach	NN
cord-015684-q10sx1dm	176	14	to	to	IN
cord-015684-q10sx1dm	176	15	functional	functional	JJ
cord-015684-q10sx1dm	176	16	genomics	genomic	NNS
cord-015684-q10sx1dm	176	17	,	,	,
cord-015684-q10sx1dm	176	18	illustrate	illustrate	VB
cord-015684-q10sx1dm	176	19	the	the	DT
cord-015684-q10sx1dm	176	20	importance	importance	NN
cord-015684-q10sx1dm	176	21	of	of	IN
cord-015684-q10sx1dm	176	22	genotype	genotype	NN
cord-015684-q10sx1dm	176	23	-	-	HYPH
cord-015684-q10sx1dm	176	24	related	relate	VBN
cord-015684-q10sx1dm	176	25	differences	difference	NNS
cord-015684-q10sx1dm	176	26	in	in	IN
cord-015684-q10sx1dm	176	27	AD	ad	NN
cord-015684-q10sx1dm	176	28	and	and	CC
cord-015684-q10sx1dm	176	29	their	-PRON-	PRP$
cord-015684-q10sx1dm	176	30	impact	impact	NN
cord-015684-q10sx1dm	176	31	on	on	IN
cord-015684-q10sx1dm	176	32	phenotype	phenotype	NN
cord-015684-q10sx1dm	176	33	expression	expression	NN
cord-015684-q10sx1dm	176	34	.	.	.
cord-015684-q10sx1dm	177	1	8	8	CD
cord-015684-q10sx1dm	177	2	,	,	,
cord-015684-q10sx1dm	177	3	[	[	-LRB-
cord-015684-q10sx1dm	177	4	16	16	CD
cord-015684-q10sx1dm	177	5	]	]	-RRB-
cord-015684-q10sx1dm	178	1	[	[	-LRB-
cord-015684-q10sx1dm	178	2	17	17	CD
cord-015684-q10sx1dm	178	3	]	]	-RRB-
cord-015684-q10sx1dm	178	4	[	[	-LRB-
cord-015684-q10sx1dm	178	5	18	18	CD
cord-015684-q10sx1dm	178	6	]	]	-RRB-
cord-015684-q10sx1dm	178	7	[	[	-LRB-
cord-015684-q10sx1dm	178	8	19	19	CD
cord-015684-q10sx1dm	178	9	]	]	-RRB-
cord-015684-q10sx1dm	179	1	[	[	-LRB-
cord-015684-q10sx1dm	179	2	20	20	CD
cord-015684-q10sx1dm	179	3	]	]	-RRB-
cord-015684-q10sx1dm	179	4	[	[	-LRB-
cord-015684-q10sx1dm	179	5	21	21	CD
cord-015684-q10sx1dm	179	6	]	]	-RRB-
cord-015684-q10sx1dm	179	7	[	[	-LRB-
cord-015684-q10sx1dm	179	8	22	22	CD
cord-015684-q10sx1dm	179	9	]	]	-RRB-
cord-015684-q10sx1dm	179	10	62	62	CD
cord-015684-q10sx1dm	179	11	,	,	,
cord-015684-q10sx1dm	179	12	63	63	CD
cord-015684-q10sx1dm	179	13	Similar	similar	JJ
cord-015684-q10sx1dm	179	14	protocols	protocol	NNS
cord-015684-q10sx1dm	179	15	are	be	VBP
cord-015684-q10sx1dm	179	16	applied	apply	VBN
cord-015684-q10sx1dm	179	17	to	to	IN
cord-015684-q10sx1dm	179	18	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	179	19	,	,	,
cord-015684-q10sx1dm	179	20	depression	depression	NN
cord-015684-q10sx1dm	179	21	,	,	,
cord-015684-q10sx1dm	179	22	anxiety	anxiety	NN
cord-015684-q10sx1dm	179	23	and	and	CC
cord-015684-q10sx1dm	179	24	other	other	JJ
cord-015684-q10sx1dm	179	25	neuropsychiatric	neuropsychiatric	JJ
cord-015684-q10sx1dm	179	26	disorders	disorder	NNS
cord-015684-q10sx1dm	179	27	.	.	.
cord-015684-q10sx1dm	180	1	Most	Most	JJS
cord-015684-q10sx1dm	180	2	biological	biological	JJ
cord-015684-q10sx1dm	180	3	parameters	parameter	NNS
cord-015684-q10sx1dm	180	4	,	,	,
cord-015684-q10sx1dm	180	5	potentially	potentially	RB
cord-015684-q10sx1dm	180	6	modifi	modifi	RB
cord-015684-q10sx1dm	180	7	able	able	JJ
cord-015684-q10sx1dm	180	8	by	by	IN
cord-015684-q10sx1dm	180	9	monogenic	monogenic	NNP
cord-015684-q10sx1dm	180	10	genotypes	genotype	NNS
cord-015684-q10sx1dm	180	11	and/or	and/or	CC
cord-015684-q10sx1dm	180	12	polygenic	polygenic	JJ
cord-015684-q10sx1dm	180	13	cluster	cluster	NN
cord-015684-q10sx1dm	180	14	profi	profi	NNP
cord-015684-q10sx1dm	180	15	les	les	FW
cord-015684-q10sx1dm	180	16	,	,	,
cord-015684-q10sx1dm	180	17	can	can	MD
cord-015684-q10sx1dm	180	18	be	be	VB
cord-015684-q10sx1dm	180	19	used	use	VBN
cord-015684-q10sx1dm	180	20	in	in	IN
cord-015684-q10sx1dm	180	21	clinical	clinical	JJ
cord-015684-q10sx1dm	180	22	trials	trial	NNS
cord-015684-q10sx1dm	180	23	for	for	IN
cord-015684-q10sx1dm	180	24	monitoring	monitor	VBG
cord-015684-q10sx1dm	180	25	effi	effi	NNP
cord-015684-q10sx1dm	180	26	cacy	cacy	NNP
cord-015684-q10sx1dm	180	27	outcomes	outcome	NNS
cord-015684-q10sx1dm	180	28	.	.	.
cord-015684-q10sx1dm	181	1	These	these	DT
cord-015684-q10sx1dm	181	2	parametric	parametric	JJ
cord-015684-q10sx1dm	181	3	variables	variable	NNS
cord-015684-q10sx1dm	181	4	also	also	RB
cord-015684-q10sx1dm	181	5	show	show	VBP
cord-015684-q10sx1dm	181	6	a	a	DT
cord-015684-q10sx1dm	181	7	genotypedependent	genotypedependent	NN
cord-015684-q10sx1dm	181	8	profi	profi	NNP
cord-015684-q10sx1dm	181	9	le	le	NNP
cord-015684-q10sx1dm	181	10	in	in	IN
cord-015684-q10sx1dm	181	11	different	different	JJ
cord-015684-q10sx1dm	181	12	types	type	NNS
cord-015684-q10sx1dm	181	13	of	of	IN
cord-015684-q10sx1dm	181	14	dementia	dementia	NN
cord-015684-q10sx1dm	181	15	(	(	-LRB-
cord-015684-q10sx1dm	181	16	e.g.	e.g.	RB
cord-015684-q10sx1dm	181	17	,	,	,
cord-015684-q10sx1dm	181	18	AD	ad	NN
cord-015684-q10sx1dm	181	19	vs.	vs.	FW
cord-015684-q10sx1dm	181	20	vascular	vascular	JJ
cord-015684-q10sx1dm	181	21	dementia	dementia	NN
cord-015684-q10sx1dm	181	22	)	)	-RRB-
cord-015684-q10sx1dm	181	23	.	.	.
cord-015684-q10sx1dm	182	1	For	for	IN
cord-015684-q10sx1dm	182	2	instance	instance	NN
cord-015684-q10sx1dm	182	3	,	,	,
cord-015684-q10sx1dm	182	4	striking	strike	VBG
cord-015684-q10sx1dm	182	5	differences	difference	NNS
cord-015684-q10sx1dm	182	6	have	have	VBP
cord-015684-q10sx1dm	182	7	been	be	VBN
cord-015684-q10sx1dm	182	8	found	find	VBN
cord-015684-q10sx1dm	182	9	between	between	IN
cord-015684-q10sx1dm	182	10	AD	ad	NN
cord-015684-q10sx1dm	182	11	and	and	CC
cord-015684-q10sx1dm	182	12	vascular	vascular	JJ
cord-015684-q10sx1dm	182	13	dementia	dementia	NN
cord-015684-q10sx1dm	182	14	in	in	IN
cord-015684-q10sx1dm	182	15	structural	structural	JJ
cord-015684-q10sx1dm	182	16	and	and	CC
cord-015684-q10sx1dm	182	17	functional	functional	JJ
cord-015684-q10sx1dm	182	18	genomics	genomic	NNS
cord-015684-q10sx1dm	182	19	studies	study	NNS
cord-015684-q10sx1dm	182	20	.	.	.
cord-015684-q10sx1dm	183	1	8	8	CD
cord-015684-q10sx1dm	183	2	,	,	,
cord-015684-q10sx1dm	183	3	[	[	-LRB-
cord-015684-q10sx1dm	183	4	16	16	CD
cord-015684-q10sx1dm	183	5	]	]	-RRB-
cord-015684-q10sx1dm	184	1	[	[	-LRB-
cord-015684-q10sx1dm	184	2	17	17	CD
cord-015684-q10sx1dm	184	3	]	]	-RRB-
cord-015684-q10sx1dm	184	4	[	[	-LRB-
cord-015684-q10sx1dm	184	5	18	18	CD
cord-015684-q10sx1dm	184	6	]	]	-RRB-
cord-015684-q10sx1dm	184	7	[	[	-LRB-
cord-015684-q10sx1dm	184	8	19	19	CD
cord-015684-q10sx1dm	184	9	]	]	-RRB-
cord-015684-q10sx1dm	185	1	[	[	-LRB-
cord-015684-q10sx1dm	185	2	20	20	CD
cord-015684-q10sx1dm	185	3	]	]	-RRB-
cord-015684-q10sx1dm	185	4	[	[	-LRB-
cord-015684-q10sx1dm	185	5	21	21	CD
cord-015684-q10sx1dm	185	6	]	]	-RRB-
cord-015684-q10sx1dm	186	1	[	[	-LRB-
cord-015684-q10sx1dm	186	2	22	22	CD
cord-015684-q10sx1dm	186	3	]	]	-RRB-
cord-015684-q10sx1dm	186	4	62	62	CD
cord-015684-q10sx1dm	186	5	,	,	,
cord-015684-q10sx1dm	186	6	63	63	CD
cord-015684-q10sx1dm	186	7	 	 	_SP
cord-015684-q10sx1dm	187	1	Our	-PRON-	PRP$
cord-015684-q10sx1dm	187	2	understanding	understanding	NN
cord-015684-q10sx1dm	187	3	of	of	IN
cord-015684-q10sx1dm	187	4	the	the	DT
cord-015684-q10sx1dm	187	5	pathophysiology	pathophysiology	NN
cord-015684-q10sx1dm	187	6	of	of	IN
cord-015684-q10sx1dm	187	7	CNS	CNS	NNP
cord-015684-q10sx1dm	187	8	disorders	disorder	NNS
cord-015684-q10sx1dm	187	9	has	have	VBZ
cord-015684-q10sx1dm	187	10	advanced	advance	VBN
cord-015684-q10sx1dm	187	11	dramatically	dramatically	RB
cord-015684-q10sx1dm	187	12	in	in	IN
cord-015684-q10sx1dm	187	13	the	the	DT
cord-015684-q10sx1dm	187	14	last	last	JJ
cord-015684-q10sx1dm	187	15	30	30	CD
cord-015684-q10sx1dm	187	16	years	year	NNS
cord-015684-q10sx1dm	187	17	,	,	,
cord-015684-q10sx1dm	187	18	especially	especially	RB
cord-015684-q10sx1dm	187	19	in	in	IN
cord-015684-q10sx1dm	187	20	terms	term	NNS
cord-015684-q10sx1dm	187	21	of	of	IN
cord-015684-q10sx1dm	187	22	their	-PRON-	PRP$
cord-015684-q10sx1dm	187	23	molecular	molecular	JJ
cord-015684-q10sx1dm	187	24	pathogenesis	pathogenesis	NN
cord-015684-q10sx1dm	187	25	and	and	CC
cord-015684-q10sx1dm	187	26	genetics	genetic	NNS
cord-015684-q10sx1dm	187	27	.	.	.
cord-015684-q10sx1dm	188	1	Drug	drug	NN
cord-015684-q10sx1dm	188	2	treatment	treatment	NN
cord-015684-q10sx1dm	188	3	of	of	IN
cord-015684-q10sx1dm	188	4	CNS	CNS	NNP
cord-015684-q10sx1dm	188	5	disorders	disorder	NNS
cord-015684-q10sx1dm	188	6	has	have	VBZ
cord-015684-q10sx1dm	188	7	also	also	RB
cord-015684-q10sx1dm	188	8	made	make	VBN
cord-015684-q10sx1dm	188	9	remarkable	remarkable	JJ
cord-015684-q10sx1dm	188	10	strides	stride	NNS
cord-015684-q10sx1dm	188	11	,	,	,
cord-015684-q10sx1dm	188	12	with	with	IN
cord-015684-q10sx1dm	188	13	the	the	DT
cord-015684-q10sx1dm	188	14	introduction	introduction	NN
cord-015684-q10sx1dm	188	15	of	of	IN
cord-015684-q10sx1dm	188	16	many	many	JJ
cord-015684-q10sx1dm	188	17	new	new	JJ
cord-015684-q10sx1dm	188	18	drugs	drug	NNS
cord-015684-q10sx1dm	188	19	for	for	IN
cord-015684-q10sx1dm	188	20	the	the	DT
cord-015684-q10sx1dm	188	21	treatment	treatment	NN
cord-015684-q10sx1dm	188	22	of	of	IN
cord-015684-q10sx1dm	188	23	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	188	24	,	,	,
cord-015684-q10sx1dm	188	25	depression	depression	NN
cord-015684-q10sx1dm	188	26	,	,	,
cord-015684-q10sx1dm	188	27	anxiety	anxiety	NN
cord-015684-q10sx1dm	188	28	,	,	,
cord-015684-q10sx1dm	188	29	epilepsy	epilepsy	NN
cord-015684-q10sx1dm	188	30	,	,	,
cord-015684-q10sx1dm	188	31	Parkinson	Parkinson	NNP
cord-015684-q10sx1dm	188	32	's	's	POS
cord-015684-q10sx1dm	188	33	disease	disease	NN
cord-015684-q10sx1dm	188	34	,	,	,
cord-015684-q10sx1dm	188	35	and	and	CC
cord-015684-q10sx1dm	188	36	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	188	37	's	's	POS
cord-015684-q10sx1dm	188	38	disease	disease	NN
cord-015684-q10sx1dm	188	39	,	,	,
cord-015684-q10sx1dm	188	40	among	among	IN
cord-015684-q10sx1dm	188	41	many	many	JJ
cord-015684-q10sx1dm	188	42	other	other	JJ
cord-015684-q10sx1dm	188	43	quantitatively	quantitatively	RB
cord-015684-q10sx1dm	188	44	and	and	CC
cord-015684-q10sx1dm	188	45	qualita	qualita	NNP
cord-015684-q10sx1dm	188	46	-	-	HYPH
cord-015684-q10sx1dm	188	47	tively	tively	JJ
cord-015684-q10sx1dm	188	48	important	important	JJ
cord-015684-q10sx1dm	188	49	neuropsychiatric	neuropsychiatric	JJ
cord-015684-q10sx1dm	188	50	disorders	disorder	NNS
cord-015684-q10sx1dm	188	51	.	.	.
cord-015684-q10sx1dm	189	1	Improvement	improvement	NN
cord-015684-q10sx1dm	189	2	in	in	IN
cord-015684-q10sx1dm	189	3	terms	term	NNS
cord-015684-q10sx1dm	189	4	of	of	IN
cord-015684-q10sx1dm	189	5	clinical	clinical	JJ
cord-015684-q10sx1dm	189	6	outcome	outcome	NN
cord-015684-q10sx1dm	189	7	,	,	,
cord-015684-q10sx1dm	189	8	however	however	RB
cord-015684-q10sx1dm	189	9	,	,	,
cord-015684-q10sx1dm	189	10	has	have	VBZ
cord-015684-q10sx1dm	189	11	fallen	fall	VBN
cord-015684-q10sx1dm	189	12	short	short	RB
cord-015684-q10sx1dm	189	13	of	of	IN
cord-015684-q10sx1dm	189	14	expectations	expectation	NNS
cord-015684-q10sx1dm	189	15	,	,	,
cord-015684-q10sx1dm	189	16	with	with	IN
cord-015684-q10sx1dm	189	17	up	up	IN
cord-015684-q10sx1dm	189	18	to	to	TO
cord-015684-q10sx1dm	189	19	one	one	CD
cord-015684-q10sx1dm	189	20	third	third	NN
cord-015684-q10sx1dm	189	21	of	of	IN
cord-015684-q10sx1dm	189	22	the	the	DT
cord-015684-q10sx1dm	189	23	patients	patient	NNS
cord-015684-q10sx1dm	189	24	continuing	continue	VBG
cord-015684-q10sx1dm	189	25	to	to	TO
cord-015684-q10sx1dm	189	26	experience	experience	VB
cord-015684-q10sx1dm	189	27	clinical	clinical	JJ
cord-015684-q10sx1dm	189	28	relapse	relapse	NN
cord-015684-q10sx1dm	189	29	or	or	CC
cord-015684-q10sx1dm	189	30	unacceptable	unacceptable	JJ
cord-015684-q10sx1dm	189	31	medication	medication	NN
cord-015684-q10sx1dm	189	32	-	-	HYPH
cord-015684-q10sx1dm	189	33	related	relate	VBN
cord-015684-q10sx1dm	189	34	side	side	NN
cord-015684-q10sx1dm	189	35	effects	effect	NNS
cord-015684-q10sx1dm	189	36	in	in	IN
cord-015684-q10sx1dm	189	37	spite	spite	NN
cord-015684-q10sx1dm	189	38	of	of	IN
cord-015684-q10sx1dm	189	39	efforts	effort	NNS
cord-015684-q10sx1dm	189	40	to	to	TO
cord-015684-q10sx1dm	189	41	identify	identify	VB
cord-015684-q10sx1dm	189	42	optimal	optimal	JJ
cord-015684-q10sx1dm	189	43	treatment	treatment	NN
cord-015684-q10sx1dm	189	44	regimes	regime	NNS
cord-015684-q10sx1dm	189	45	with	with	IN
cord-015684-q10sx1dm	189	46	one	one	CD
cord-015684-q10sx1dm	189	47	or	or	CC
cord-015684-q10sx1dm	189	48	more	more	JJR
cord-015684-q10sx1dm	189	49	drugs	drug	NNS
cord-015684-q10sx1dm	189	50	.	.	.
cord-015684-q10sx1dm	190	1	68	68	CD
cord-015684-q10sx1dm	191	1	Potential	potential	JJ
cord-015684-q10sx1dm	191	2	reasons	reason	NNS
cord-015684-q10sx1dm	191	3	to	to	TO
cord-015684-q10sx1dm	191	4	explain	explain	VB
cord-015684-q10sx1dm	191	5	this	this	DT
cord-015684-q10sx1dm	191	6	historical	historical	JJ
cord-015684-q10sx1dm	191	7	setback	setback	NN
cord-015684-q10sx1dm	191	8	might	may	MD
cord-015684-q10sx1dm	191	9	be	be	VB
cord-015684-q10sx1dm	191	10	that	that	DT
cord-015684-q10sx1dm	191	11	:	:	:
cord-015684-q10sx1dm	191	12	(	(	-LRB-
cord-015684-q10sx1dm	191	13	a	a	LS
cord-015684-q10sx1dm	191	14	)	)	-RRB-
cord-015684-q10sx1dm	191	15	the	the	DT
cord-015684-q10sx1dm	191	16	molecular	molecular	JJ
cord-015684-q10sx1dm	191	17	pathology	pathology	NN
cord-015684-q10sx1dm	191	18	of	of	IN
cord-015684-q10sx1dm	191	19	most	most	JJS
cord-015684-q10sx1dm	191	20	CNS	CNS	NNP
cord-015684-q10sx1dm	191	21	disorders	disorder	NNS
cord-015684-q10sx1dm	191	22	is	be	VBZ
cord-015684-q10sx1dm	191	23	still	still	RB
cord-015684-q10sx1dm	191	24	poorly	poorly	RB
cord-015684-q10sx1dm	191	25	understood	understand	VBN
cord-015684-q10sx1dm	191	26	;	;	:
cord-015684-q10sx1dm	191	27	(	(	-LRB-
cord-015684-q10sx1dm	191	28	b	b	NN
cord-015684-q10sx1dm	191	29	)	)	-RRB-
cord-015684-q10sx1dm	191	30	drug	drug	NN
cord-015684-q10sx1dm	191	31	targets	target	NNS
cord-015684-q10sx1dm	191	32	are	be	VBP
cord-015684-q10sx1dm	191	33	inappropriate	inappropriate	JJ
cord-015684-q10sx1dm	191	34	,	,	,
cord-015684-q10sx1dm	191	35	not	not	RB
cord-015684-q10sx1dm	191	36	fi	fi	VB
cord-015684-q10sx1dm	191	37	tting	tting	NN
cord-015684-q10sx1dm	191	38	into	into	IN
cord-015684-q10sx1dm	191	39	the	the	DT
cord-015684-q10sx1dm	191	40	real	real	JJ
cord-015684-q10sx1dm	191	41	etiology	etiology	NN
cord-015684-q10sx1dm	191	42	of	of	IN
cord-015684-q10sx1dm	191	43	the	the	DT
cord-015684-q10sx1dm	191	44	disease	disease	NN
cord-015684-q10sx1dm	191	45	;	;	,
cord-015684-q10sx1dm	191	46	(	(	-LRB-
cord-015684-q10sx1dm	191	47	c	c	NN
cord-015684-q10sx1dm	191	48	)	)	-RRB-
cord-015684-q10sx1dm	191	49	most	most	JJS
cord-015684-q10sx1dm	191	50	treatments	treatment	NNS
cord-015684-q10sx1dm	191	51	are	be	VBP
cord-015684-q10sx1dm	191	52	symptomatic	symptomatic	JJ
cord-015684-q10sx1dm	191	53	,	,	,
cord-015684-q10sx1dm	191	54	but	but	CC
cord-015684-q10sx1dm	191	55	not	not	RB
cord-015684-q10sx1dm	191	56	anti	anti	JJ
cord-015684-q10sx1dm	191	57	-	-	JJ
cord-015684-q10sx1dm	191	58	pathogenic	pathogenic	JJ
cord-015684-q10sx1dm	191	59	;	;	:
cord-015684-q10sx1dm	191	60	(	(	-LRB-
cord-015684-q10sx1dm	191	61	d	d	LS
cord-015684-q10sx1dm	191	62	)	)	-RRB-
cord-015684-q10sx1dm	191	63	the	the	DT
cord-015684-q10sx1dm	191	64	genetic	genetic	JJ
cord-015684-q10sx1dm	191	65	component	component	NN
cord-015684-q10sx1dm	191	66	of	of	IN
cord-015684-q10sx1dm	191	67	most	most	JJS
cord-015684-q10sx1dm	191	68	CNS	CNS	NNP
cord-015684-q10sx1dm	191	69	disorders	disorder	NNS
cord-015684-q10sx1dm	191	70	is	be	VBZ
cord-015684-q10sx1dm	191	71	poorly	poorly	RB
cord-015684-q10sx1dm	191	72	defi	defi	XX
cord-015684-q10sx1dm	191	73	ned	ned	NN
cord-015684-q10sx1dm	191	74	;	;	:
cord-015684-q10sx1dm	191	75	and	and	CC
cord-015684-q10sx1dm	191	76	(	(	-LRB-
cord-015684-q10sx1dm	191	77	e	e	LS
cord-015684-q10sx1dm	191	78	)	)	-RRB-
cord-015684-q10sx1dm	191	79	the	the	DT
cord-015684-q10sx1dm	191	80	understanding	understanding	NN
cord-015684-q10sx1dm	191	81	of	of	IN
cord-015684-q10sx1dm	191	82	genome	genome	NN
cord-015684-q10sx1dm	191	83	-	-	HYPH
cord-015684-q10sx1dm	191	84	drug	drug	NN
cord-015684-q10sx1dm	191	85	interactions	interaction	NNS
cord-015684-q10sx1dm	191	86	is	be	VBZ
cord-015684-q10sx1dm	191	87	very	very	RB
cord-015684-q10sx1dm	191	88	limited	limited	JJ
cord-015684-q10sx1dm	191	89	.	.	.
cord-015684-q10sx1dm	192	1	With	with	IN
cord-015684-q10sx1dm	192	2	the	the	DT
cord-015684-q10sx1dm	192	3	advent	advent	NN
cord-015684-q10sx1dm	192	4	of	of	IN
cord-015684-q10sx1dm	192	5	recent	recent	JJ
cord-015684-q10sx1dm	192	6	knowledge	knowledge	NN
cord-015684-q10sx1dm	192	7	on	on	IN
cord-015684-q10sx1dm	192	8	the	the	DT
cord-015684-q10sx1dm	192	9	human	human	JJ
cord-015684-q10sx1dm	192	10	genome	genome	NN
cord-015684-q10sx1dm	192	11	69,70	69,70	CD
cord-015684-q10sx1dm	192	12	and	and	CC
cord-015684-q10sx1dm	192	13	the	the	DT
cord-015684-q10sx1dm	192	14	identifi	identifi	NNP
cord-015684-q10sx1dm	192	15	cation	cation	NN
cord-015684-q10sx1dm	192	16	and	and	CC
cord-015684-q10sx1dm	192	17	characterization	characterization	NN
cord-015684-q10sx1dm	192	18	of	of	IN
cord-015684-q10sx1dm	192	19	many	many	JJ
cord-015684-q10sx1dm	192	20	genes	gene	NNS
cord-015684-q10sx1dm	192	21	associated	associate	VBN
cord-015684-q10sx1dm	192	22	with	with	IN
cord-015684-q10sx1dm	192	23	CNS	CNS	NNP
cord-015684-q10sx1dm	192	24	disorders	disorder	NNS
cord-015684-q10sx1dm	192	25	,	,	,
cord-015684-q10sx1dm	192	26	8	8	CD
cord-015684-q10sx1dm	192	27	,	,	,
cord-015684-q10sx1dm	192	28	19	19	CD
cord-015684-q10sx1dm	192	29	as	as	RB
cord-015684-q10sx1dm	192	30	well	well	RB
cord-015684-q10sx1dm	192	31	as	as	IN
cord-015684-q10sx1dm	192	32	novel	novel	JJ
cord-015684-q10sx1dm	192	33	data	datum	NNS
cord-015684-q10sx1dm	192	34	regarding	regard	VBG
cord-015684-q10sx1dm	192	35	CYP	CYP	NNP
cord-015684-q10sx1dm	192	36	family	family	NN
cord-015684-q10sx1dm	192	37	genes	gene	NNS
cord-015684-q10sx1dm	192	38	and	and	CC
cord-015684-q10sx1dm	192	39	other	other	JJ
cord-015684-q10sx1dm	192	40	genes	gene	NNS
cord-015684-q10sx1dm	192	41	whose	whose	WP$
cord-015684-q10sx1dm	192	42	enzymatic	enzymatic	JJ
cord-015684-q10sx1dm	192	43	products	product	NNS
cord-015684-q10sx1dm	192	44	are	be	VBP
cord-015684-q10sx1dm	192	45	responsible	responsible	JJ
cord-015684-q10sx1dm	192	46	for	for	IN
cord-015684-q10sx1dm	192	47	drug	drug	NN
cord-015684-q10sx1dm	192	48	metabolism	metabolism	NN
cord-015684-q10sx1dm	192	49	in	in	IN
cord-015684-q10sx1dm	192	50	the	the	DT
cord-015684-q10sx1dm	192	51	liver	liver	NN
cord-015684-q10sx1dm	192	52	(	(	-LRB-
cord-015684-q10sx1dm	192	53	e.g.	e.g.	RB
cord-015684-q10sx1dm	192	54	,	,	,
cord-015684-q10sx1dm	192	55	NATs	NATs	NNP
cord-015684-q10sx1dm	192	56	,	,	,
cord-015684-q10sx1dm	192	57	ABCBs/	ABCBs/	NNP
cord-015684-q10sx1dm	192	58	MDRs	mdr	NNS
cord-015684-q10sx1dm	192	59	,	,	,
cord-015684-q10sx1dm	192	60	TPMT	TPMT	NNP
cord-015684-q10sx1dm	192	61	)	)	-RRB-
cord-015684-q10sx1dm	192	62	,	,	,
cord-015684-q10sx1dm	192	63	it	-PRON-	PRP
cord-015684-q10sx1dm	192	64	has	have	VBZ
cord-015684-q10sx1dm	192	65	been	be	VBN
cord-015684-q10sx1dm	192	66	convincingly	convincingly	RB
cord-015684-q10sx1dm	192	67	postulated	postulate	VBN
cord-015684-q10sx1dm	192	68	that	that	IN
cord-015684-q10sx1dm	192	69	the	the	DT
cord-015684-q10sx1dm	192	70	incorporation	incorporation	NN
cord-015684-q10sx1dm	192	71	of	of	IN
cord-015684-q10sx1dm	192	72	pharmacogenetic	pharmacogenetic	NNP
cord-015684-q10sx1dm	192	73	and	and	CC
cord-015684-q10sx1dm	192	74	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	192	75	procedures	procedure	NNS
cord-015684-q10sx1dm	192	76	(	(	-LRB-
cord-015684-q10sx1dm	192	77	Fig	Fig	NNP
cord-015684-q10sx1dm	192	78	.	.	.
cord-015684-q10sx1dm	192	79	40	40	CD
cord-015684-q10sx1dm	192	80	.6	.6	CD
cord-015684-q10sx1dm	192	81	)	)	-RRB-
cord-015684-q10sx1dm	192	82	in	in	IN
cord-015684-q10sx1dm	192	83	drug	drug	NN
cord-015684-q10sx1dm	192	84	development	development	NN
cord-015684-q10sx1dm	192	85	might	may	MD
cord-015684-q10sx1dm	192	86	bring	bring	VB
cord-015684-q10sx1dm	192	87	about	about	RP
cord-015684-q10sx1dm	192	88	substantial	substantial	JJ
cord-015684-q10sx1dm	192	89	benefi	benefi	JJ
cord-015684-q10sx1dm	192	90	ts	ts	NN
cord-015684-q10sx1dm	192	91	in	in	IN
cord-015684-q10sx1dm	192	92	terms	term	NNS
cord-015684-q10sx1dm	192	93	of	of	IN
cord-015684-q10sx1dm	192	94	therapeutics	therapeutic	NNS
cord-015684-q10sx1dm	192	95	optimization	optimization	NN
cord-015684-q10sx1dm	192	96	in	in	IN
cord-015684-q10sx1dm	192	97	CNS	CNS	NNP
cord-015684-q10sx1dm	192	98	disorders	disorder	NNS
cord-015684-q10sx1dm	192	99	and	and	CC
cord-015684-q10sx1dm	192	100	in	in	IN
cord-015684-q10sx1dm	192	101	many	many	JJ
cord-015684-q10sx1dm	192	102	other	other	JJ
cord-015684-q10sx1dm	192	103	complex	complex	JJ
cord-015684-q10sx1dm	192	104	disorders	disorder	NNS
cord-015684-q10sx1dm	192	105	,	,	,
cord-015684-q10sx1dm	192	106	assuming	assume	VBG
cord-015684-q10sx1dm	192	107	that	that	IN
cord-015684-q10sx1dm	192	108	genetic	genetic	JJ
cord-015684-q10sx1dm	192	109	factors	factor	NNS
cord-015684-q10sx1dm	192	110	are	be	VBP
cord-015684-q10sx1dm	192	111	determinant	determinant	JJ
cord-015684-q10sx1dm	192	112	for	for	IN
cord-015684-q10sx1dm	192	113	both	both	DT
cord-015684-q10sx1dm	192	114	neuronal	neuronal	JJ
cord-015684-q10sx1dm	192	115	dysregulation	dysregulation	NN
cord-015684-q10sx1dm	192	116	(	(	-LRB-
cord-015684-q10sx1dm	192	117	and/or	and/or	CC
cord-015684-q10sx1dm	192	118	neuronal	neuronal	JJ
cord-015684-q10sx1dm	192	119	death	death	NN
cord-015684-q10sx1dm	192	120	)	)	-RRB-
cord-015684-q10sx1dm	192	121	8,16	8,16	CD
cord-015684-q10sx1dm	192	122	-	-	SYM
cord-015684-q10sx1dm	192	123	22	22	CD
cord-015684-q10sx1dm	192	124	and	and	CC
cord-015684-q10sx1dm	192	125	drug	drug	NN
cord-015684-q10sx1dm	192	126	metabolism	metabolism	NN
cord-015684-q10sx1dm	192	127	.	.	.
cord-015684-q10sx1dm	193	1	[	[	-LRB-
cord-015684-q10sx1dm	193	2	71	71	CD
cord-015684-q10sx1dm	193	3	]	]	-RRB-
cord-015684-q10sx1dm	193	4	[	[	-LRB-
cord-015684-q10sx1dm	193	5	72	72	CD
cord-015684-q10sx1dm	193	6	]	]	-RRB-
cord-015684-q10sx1dm	194	1	[	[	-LRB-
cord-015684-q10sx1dm	194	2	73	73	CD
cord-015684-q10sx1dm	194	3	]	]	-RRB-
cord-015684-q10sx1dm	195	1	Fig	Fig	NNP
cord-015684-q10sx1dm	195	2	.	.	.
cord-015684-q10sx1dm	196	1	40.6	40.6	CD
cord-015684-q10sx1dm	197	1	Effi	Effi	NNP
cord-015684-q10sx1dm	197	2	cacy	cacy	NN
cord-015684-q10sx1dm	197	3	and	and	CC
cord-015684-q10sx1dm	197	4	safety	safety	NN
cord-015684-q10sx1dm	197	5	issues	issue	NNS
cord-015684-q10sx1dm	197	6	associated	associate	VBN
cord-015684-q10sx1dm	197	7	with	with	IN
cord-015684-q10sx1dm	197	8	pharmacogenetics	pharmacogenetic	NNS
cord-015684-q10sx1dm	197	9	and	and	CC
cord-015684-q10sx1dm	197	10	pharmacogenomics	pharmacogenomics	NNP
cord-015684-q10sx1dm	198	1	(	(	-LRB-
cord-015684-q10sx1dm	198	2	Adapted	adapt	VBN
cord-015684-q10sx1dm	198	3	from	from	IN
cord-015684-q10sx1dm	198	4	R.	R.	NNP
cord-015684-q10sx1dm	198	5	Cacabelos	Cacabelos	NNP
cord-015684-q10sx1dm	198	6	19	19	CD
cord-015684-q10sx1dm	198	7	,	,	,
cord-015684-q10sx1dm	198	8	20	20	CD
cord-015684-q10sx1dm	198	9	)	)	-RRB-
cord-015684-q10sx1dm	199	1	However	however	RB
cord-015684-q10sx1dm	199	2	,	,	,
cord-015684-q10sx1dm	199	3	this	this	DT
cord-015684-q10sx1dm	199	4	fi	fi	XX
cord-015684-q10sx1dm	199	5	eld	eld	NNP
cord-015684-q10sx1dm	199	6	is	be	VBZ
cord-015684-q10sx1dm	199	7	still	still	RB
cord-015684-q10sx1dm	199	8	in	in	IN
cord-015684-q10sx1dm	199	9	its	-PRON-	PRP$
cord-015684-q10sx1dm	199	10	infancy	infancy	NN
cord-015684-q10sx1dm	199	11	;	;	:
cord-015684-q10sx1dm	199	12	and	and	CC
cord-015684-q10sx1dm	199	13	the	the	DT
cord-015684-q10sx1dm	199	14	incorporation	incorporation	NN
cord-015684-q10sx1dm	199	15	of	of	IN
cord-015684-q10sx1dm	199	16	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	199	17	strategies	strategy	NNS
cord-015684-q10sx1dm	199	18	to	to	IN
cord-015684-q10sx1dm	199	19	drug	drug	NN
cord-015684-q10sx1dm	199	20	development	development	NN
cord-015684-q10sx1dm	199	21	and	and	CC
cord-015684-q10sx1dm	199	22	pharmacological	pharmacological	JJ
cord-015684-q10sx1dm	199	23	screening	screening	NN
cord-015684-q10sx1dm	199	24	in	in	IN
cord-015684-q10sx1dm	199	25	CNS	CNS	NNP
cord-015684-q10sx1dm	199	26	disorders	disorder	NNS
cord-015684-q10sx1dm	199	27	is	be	VBZ
cord-015684-q10sx1dm	199	28	not	not	RB
cord-015684-q10sx1dm	199	29	an	an	DT
cord-015684-q10sx1dm	199	30	easy	easy	JJ
cord-015684-q10sx1dm	199	31	task	task	NN
cord-015684-q10sx1dm	199	32	.	.	.
cord-015684-q10sx1dm	200	1	The	the	DT
cord-015684-q10sx1dm	200	2	natural	natural	JJ
cord-015684-q10sx1dm	200	3	course	course	NN
cord-015684-q10sx1dm	200	4	of	of	IN
cord-015684-q10sx1dm	200	5	technical	technical	JJ
cord-015684-q10sx1dm	200	6	events	event	NNS
cord-015684-q10sx1dm	200	7	to	to	TO
cord-015684-q10sx1dm	200	8	achieve	achieve	VB
cord-015684-q10sx1dm	200	9	effi	effi	NNP
cord-015684-q10sx1dm	200	10	cient	cient	NNP
cord-015684-q10sx1dm	200	11	goals	goal	NNS
cord-015684-q10sx1dm	200	12	in	in	IN
cord-015684-q10sx1dm	200	13	pharmacogenetics	pharmacogenetic	NNS
cord-015684-q10sx1dm	200	14	and	and	CC
cord-015684-q10sx1dm	200	15	pharmacogenomics	pharmacogenomic	NNS
cord-015684-q10sx1dm	200	16	include	include	VBP
cord-015684-q10sx1dm	200	17	the	the	DT
cord-015684-q10sx1dm	200	18	following	follow	VBG
cord-015684-q10sx1dm	200	19	steps	step	NNS
cord-015684-q10sx1dm	200	20	:	:	:
cord-015684-q10sx1dm	200	21	(	(	-LRB-
cord-015684-q10sx1dm	200	22	a	a	DT
cord-015684-q10sx1dm	200	23	)	)	-RRB-
cord-015684-q10sx1dm	200	24	genetic	genetic	JJ
cord-015684-q10sx1dm	200	25	testing	testing	NN
cord-015684-q10sx1dm	200	26	of	of	IN
cord-015684-q10sx1dm	200	27	mutant	mutant	JJ
cord-015684-q10sx1dm	200	28	genes	gene	NNS
cord-015684-q10sx1dm	200	29	and/or	and/or	CC
cord-015684-q10sx1dm	200	30	polymorphic	polymorphic	JJ
cord-015684-q10sx1dm	200	31	variants	variant	NNS
cord-015684-q10sx1dm	200	32	of	of	IN
cord-015684-q10sx1dm	200	33	risk	risk	NN
cord-015684-q10sx1dm	200	34	;	;	:
cord-015684-q10sx1dm	200	35	(	(	-LRB-
cord-015684-q10sx1dm	200	36	b	b	NN
cord-015684-q10sx1dm	200	37	)	)	-RRB-
cord-015684-q10sx1dm	200	38	genomic	genomic	JJ
cord-015684-q10sx1dm	200	39	screening	screening	NN
cord-015684-q10sx1dm	200	40	,	,	,
cord-015684-q10sx1dm	200	41	and	and	CC
cord-015684-q10sx1dm	200	42	understanding	understanding	NN
cord-015684-q10sx1dm	200	43	of	of	IN
cord-015684-q10sx1dm	200	44	transcriptomic	transcriptomic	NNP
cord-015684-q10sx1dm	200	45	,	,	,
cord-015684-q10sx1dm	200	46	proteomic	proteomic	JJ
cord-015684-q10sx1dm	200	47	,	,	,
cord-015684-q10sx1dm	200	48	and	and	CC
cord-015684-q10sx1dm	200	49	metabolomic	metabolomic	JJ
cord-015684-q10sx1dm	200	50	networks	network	NNS
cord-015684-q10sx1dm	200	51	;	;	,
cord-015684-q10sx1dm	200	52	(	(	-LRB-
cord-015684-q10sx1dm	200	53	c	c	NN
cord-015684-q10sx1dm	200	54	)	)	-RRB-
cord-015684-q10sx1dm	200	55	functional	functional	JJ
cord-015684-q10sx1dm	200	56	genomics	genomic	NNS
cord-015684-q10sx1dm	200	57	studies	study	NNS
cord-015684-q10sx1dm	200	58	and	and	CC
cord-015684-q10sx1dm	200	59	genotype	genotype	NN
cord-015684-q10sx1dm	200	60	-	-	HYPH
cord-015684-q10sx1dm	200	61	phenotype	phenotype	NN
cord-015684-q10sx1dm	200	62	correlation	correlation	NN
cord-015684-q10sx1dm	200	63	analysis	analysis	NN
cord-015684-q10sx1dm	200	64	;	;	,
cord-015684-q10sx1dm	200	65	and	and	CC
cord-015684-q10sx1dm	200	66	(	(	-LRB-
cord-015684-q10sx1dm	200	67	d	d	NNP
cord-015684-q10sx1dm	200	68	)	)	-RRB-
cord-015684-q10sx1dm	200	69	pharmacogenetics	pharmacogenetics	NNP
cord-015684-q10sx1dm	200	70	and	and	CC
cord-015684-q10sx1dm	200	71	pharmacogenomics	pharmacogenomic	NNS
cord-015684-q10sx1dm	200	72	developments	development	NNS
cord-015684-q10sx1dm	200	73	,	,	,
cord-015684-q10sx1dm	200	74	addressing	address	VBG
cord-015684-q10sx1dm	200	75	drug	drug	NN
cord-015684-q10sx1dm	200	76	safety	safety	NN
cord-015684-q10sx1dm	200	77	and	and	CC
cord-015684-q10sx1dm	200	78	effi	effi	NNP
cord-015684-q10sx1dm	200	79	cacy	cacy	NNP
cord-015684-q10sx1dm	200	80	,	,	,
cord-015684-q10sx1dm	200	81	respectively	respectively	RB
cord-015684-q10sx1dm	200	82	.	.	.
cord-015684-q10sx1dm	201	1	8	8	CD
cord-015684-q10sx1dm	201	2	,	,	,
cord-015684-q10sx1dm	201	3	[	[	-LRB-
cord-015684-q10sx1dm	201	4	16	16	CD
cord-015684-q10sx1dm	201	5	]	]	-RRB-
cord-015684-q10sx1dm	201	6	[	[	-LRB-
cord-015684-q10sx1dm	201	7	17	17	CD
cord-015684-q10sx1dm	201	8	]	]	-RRB-
cord-015684-q10sx1dm	201	9	[	[	-LRB-
cord-015684-q10sx1dm	201	10	18	18	CD
cord-015684-q10sx1dm	201	11	]	]	-RRB-
cord-015684-q10sx1dm	201	12	[	[	-LRB-
cord-015684-q10sx1dm	201	13	19	19	CD
cord-015684-q10sx1dm	201	14	]	]	-RRB-
cord-015684-q10sx1dm	201	15	[	[	-LRB-
cord-015684-q10sx1dm	201	16	20	20	CD
cord-015684-q10sx1dm	201	17	]	]	-RRB-
cord-015684-q10sx1dm	201	18	[	[	-LRB-
cord-015684-q10sx1dm	201	19	21	21	CD
cord-015684-q10sx1dm	201	20	]	]	-RRB-
cord-015684-q10sx1dm	201	21	[	[	-LRB-
cord-015684-q10sx1dm	201	22	22	22	CD
cord-015684-q10sx1dm	201	23	]	]	-RRB-
cord-015684-q10sx1dm	201	24	[	[	-LRB-
cord-015684-q10sx1dm	201	25	74	74	CD
cord-015684-q10sx1dm	201	26	]	]	-RRB-
cord-015684-q10sx1dm	201	27	[	[	-LRB-
cord-015684-q10sx1dm	201	28	75	75	CD
cord-015684-q10sx1dm	201	29	]	]	-RRB-
cord-015684-q10sx1dm	201	30	[	[	-LRB-
cord-015684-q10sx1dm	201	31	76	76	CD
cord-015684-q10sx1dm	201	32	]	]	-RRB-
cord-015684-q10sx1dm	201	33	[	[	-LRB-
cord-015684-q10sx1dm	201	34	77	77	CD
cord-015684-q10sx1dm	201	35	]	]	-RRB-
cord-015684-q10sx1dm	202	1	With	with	IN
cord-015684-q10sx1dm	202	2	pharmacogenetics	pharmacogenetic	NNS
cord-015684-q10sx1dm	202	3	we	-PRON-	PRP
cord-015684-q10sx1dm	202	4	can	can	MD
cord-015684-q10sx1dm	202	5	understand	understand	VB
cord-015684-q10sx1dm	202	6	how	how	WRB
cord-015684-q10sx1dm	202	7	genomic	genomic	JJ
cord-015684-q10sx1dm	202	8	factors	factor	NNS
cord-015684-q10sx1dm	202	9	associated	associate	VBN
cord-015684-q10sx1dm	202	10	with	with	IN
cord-015684-q10sx1dm	202	11	genes	gene	NNS
cord-015684-q10sx1dm	202	12	encoding	encoding	NN
cord-015684-q10sx1dm	202	13	enzymes	enzyme	NNS
cord-015684-q10sx1dm	202	14	responsible	responsible	JJ
cord-015684-q10sx1dm	202	15	for	for	IN
cord-015684-q10sx1dm	202	16	drug	drug	NN
cord-015684-q10sx1dm	202	17	metabolism	metabolism	NN
cord-015684-q10sx1dm	202	18	regulate	regulate	VBP
cord-015684-q10sx1dm	202	19	pharmacokinetics	pharmacokinetic	NNS
cord-015684-q10sx1dm	202	20	and	and	CC
cord-015684-q10sx1dm	202	21	pharmacodynamics	pharmacodynamic	NNS
cord-015684-q10sx1dm	202	22	(	(	-LRB-
cord-015684-q10sx1dm	202	23	mostly	mostly	RB
cord-015684-q10sx1dm	202	24	safety	safety	NN
cord-015684-q10sx1dm	202	25	issues	issue	NNS
cord-015684-q10sx1dm	202	26	)	)	-RRB-
cord-015684-q10sx1dm	202	27	.	.	.
cord-015684-q10sx1dm	203	1	[	[	-LRB-
cord-015684-q10sx1dm	203	2	78	78	CD
cord-015684-q10sx1dm	203	3	]	]	-RRB-
cord-015684-q10sx1dm	203	4	[	[	-LRB-
cord-015684-q10sx1dm	203	5	79	79	CD
cord-015684-q10sx1dm	203	6	]	]	-RRB-
cord-015684-q10sx1dm	204	1	[	[	-LRB-
cord-015684-q10sx1dm	204	2	80	80	CD
cord-015684-q10sx1dm	204	3	]	]	-RRB-
cord-015684-q10sx1dm	205	1	With	with	IN
cord-015684-q10sx1dm	205	2	pharmacogenomics	pharmacogenomic	NNS
cord-015684-q10sx1dm	205	3	we	-PRON-	PRP
cord-015684-q10sx1dm	205	4	can	can	MD
cord-015684-q10sx1dm	205	5	differentiate	differentiate	VB
cord-015684-q10sx1dm	205	6	the	the	DT
cord-015684-q10sx1dm	205	7	specifi	specifi	NN
cord-015684-q10sx1dm	205	8	c	c	NN
cord-015684-q10sx1dm	205	9	disease	disease	NN
cord-015684-q10sx1dm	205	10	-	-	HYPH
cord-015684-q10sx1dm	205	11	modifying	modify	VBG
cord-015684-q10sx1dm	205	12	effects	effect	NNS
cord-015684-q10sx1dm	205	13	of	of	IN
cord-015684-q10sx1dm	205	14	drugs	drug	NNS
cord-015684-q10sx1dm	205	15	(	(	-LRB-
cord-015684-q10sx1dm	205	16	effi	effi	NNP
cord-015684-q10sx1dm	205	17	cacy	cacy	NNP
cord-015684-q10sx1dm	205	18	issues	issue	NNS
cord-015684-q10sx1dm	205	19	)	)	-RRB-
cord-015684-q10sx1dm	205	20	acting	act	VBG
cord-015684-q10sx1dm	205	21	on	on	IN
cord-015684-q10sx1dm	205	22	pathogenic	pathogenic	JJ
cord-015684-q10sx1dm	205	23	mechanisms	mechanism	NNS
cord-015684-q10sx1dm	205	24	directly	directly	RB
cord-015684-q10sx1dm	205	25	linked	link	VBN
cord-015684-q10sx1dm	205	26	to	to	IN
cord-015684-q10sx1dm	205	27	genes	gene	NNS
cord-015684-q10sx1dm	205	28	whose	whose	WP$
cord-015684-q10sx1dm	205	29	mutations	mutation	NNS
cord-015684-q10sx1dm	205	30	determine	determine	VBP
cord-015684-q10sx1dm	205	31	the	the	DT
cord-015684-q10sx1dm	205	32	disease	disease	NN
cord-015684-q10sx1dm	205	33	phenotype	phenotype	NN
cord-015684-q10sx1dm	205	34	.	.	.
cord-015684-q10sx1dm	206	1	[	[	-LRB-
cord-015684-q10sx1dm	206	2	16	16	CD
cord-015684-q10sx1dm	206	3	]	]	-RRB-
cord-015684-q10sx1dm	206	4	[	[	-LRB-
cord-015684-q10sx1dm	206	5	17	17	CD
cord-015684-q10sx1dm	206	6	]	]	-RRB-
cord-015684-q10sx1dm	206	7	[	[	-LRB-
cord-015684-q10sx1dm	206	8	18	18	CD
cord-015684-q10sx1dm	206	9	]	]	-RRB-
cord-015684-q10sx1dm	206	10	[	[	-LRB-
cord-015684-q10sx1dm	206	11	19	19	CD
cord-015684-q10sx1dm	206	12	]	]	-RRB-
cord-015684-q10sx1dm	207	1	[	[	-LRB-
cord-015684-q10sx1dm	207	2	20	20	CD
cord-015684-q10sx1dm	207	3	]	]	-RRB-
cord-015684-q10sx1dm	207	4	[	[	-LRB-
cord-015684-q10sx1dm	207	5	21	21	CD
cord-015684-q10sx1dm	207	6	]	]	-RRB-
cord-015684-q10sx1dm	208	1	[	[	-LRB-
cord-015684-q10sx1dm	208	2	22	22	CD
cord-015684-q10sx1dm	208	3	]	]	-RRB-
cord-015684-q10sx1dm	208	4	[	[	-LRB-
cord-015684-q10sx1dm	208	5	74	74	CD
cord-015684-q10sx1dm	208	6	]	]	-RRB-
cord-015684-q10sx1dm	209	1	[	[	-LRB-
cord-015684-q10sx1dm	209	2	75	75	CD
cord-015684-q10sx1dm	209	3	]	]	-RRB-
cord-015684-q10sx1dm	209	4	[	[	-LRB-
cord-015684-q10sx1dm	209	5	76	76	CD
cord-015684-q10sx1dm	209	6	]	]	-RRB-
cord-015684-q10sx1dm	209	7	[	[	-LRB-
cord-015684-q10sx1dm	209	8	77	77	CD
cord-015684-q10sx1dm	209	9	]	]	-RRB-
cord-015684-q10sx1dm	210	1	The	the	DT
cord-015684-q10sx1dm	210	2	capacity	capacity	NN
cord-015684-q10sx1dm	210	3	of	of	IN
cord-015684-q10sx1dm	210	4	drugs	drug	NNS
cord-015684-q10sx1dm	210	5	to	to	TO
cord-015684-q10sx1dm	210	6	reverse	reverse	VB
cord-015684-q10sx1dm	210	7	the	the	DT
cord-015684-q10sx1dm	210	8	effects	effect	NNS
cord-015684-q10sx1dm	210	9	of	of	IN
cord-015684-q10sx1dm	210	10	the	the	DT
cord-015684-q10sx1dm	210	11	activation	activation	NN
cord-015684-q10sx1dm	210	12	of	of	IN
cord-015684-q10sx1dm	210	13	pathogenic	pathogenic	JJ
cord-015684-q10sx1dm	210	14	cascades	cascade	NNS
cord-015684-q10sx1dm	210	15	(	(	-LRB-
cord-015684-q10sx1dm	210	16	phenotype	phenotype	NN
cord-015684-q10sx1dm	210	17	expression	expression	NN
cord-015684-q10sx1dm	210	18	)	)	-RRB-
cord-015684-q10sx1dm	210	19	regulated	regulate	VBN
cord-015684-q10sx1dm	210	20	by	by	IN
cord-015684-q10sx1dm	210	21	networking	networking	NN
cord-015684-q10sx1dm	210	22	genes	gene	NNS
cord-015684-q10sx1dm	210	23	basically	basically	RB
cord-015684-q10sx1dm	210	24	deals	deal	VBZ
cord-015684-q10sx1dm	210	25	with	with	IN
cord-015684-q10sx1dm	210	26	effi	effi	NNP
cord-015684-q10sx1dm	210	27	cacy	cacy	NNP
cord-015684-q10sx1dm	210	28	issues	issue	NNS
cord-015684-q10sx1dm	210	29	.	.	.
cord-015684-q10sx1dm	211	1	At	at	IN
cord-015684-q10sx1dm	211	2	present	present	NN
cord-015684-q10sx1dm	211	3	,	,	,
cord-015684-q10sx1dm	211	4	the	the	DT
cord-015684-q10sx1dm	211	5	terms	term	NNS
cord-015684-q10sx1dm	211	6	pharmacogenetics	pharmacogenetic	NNS
cord-015684-q10sx1dm	211	7	and	and	CC
cord-015684-q10sx1dm	211	8	pharmacogenomics	pharmacogenomic	NNS
cord-015684-q10sx1dm	211	9	are	be	VBP
cord-015684-q10sx1dm	211	10	often	often	RB
cord-015684-q10sx1dm	211	11	used	use	VBN
cord-015684-q10sx1dm	211	12	interchangeably	interchangeably	RB
cord-015684-q10sx1dm	211	13	to	to	TO
cord-015684-q10sx1dm	211	14	refer	refer	VB
cord-015684-q10sx1dm	211	15	to	to	IN
cord-015684-q10sx1dm	211	16	studies	study	NNS
cord-015684-q10sx1dm	211	17	of	of	IN
cord-015684-q10sx1dm	211	18	the	the	DT
cord-015684-q10sx1dm	211	19	contribution	contribution	NN
cord-015684-q10sx1dm	211	20	of	of	IN
cord-015684-q10sx1dm	211	21	inheritance	inheritance	NN
cord-015684-q10sx1dm	211	22	to	to	IN
cord-015684-q10sx1dm	211	23	variation	variation	NN
cord-015684-q10sx1dm	211	24	in	in	IN
cord-015684-q10sx1dm	211	25	the	the	DT
cord-015684-q10sx1dm	211	26	drug	drug	NN
cord-015684-q10sx1dm	211	27	response	response	NN
cord-015684-q10sx1dm	211	28	phenotype	phenotype	NN
cord-015684-q10sx1dm	211	29	73	73	CD
cord-015684-q10sx1dm	211	30	;	;	:
cord-015684-q10sx1dm	211	31	however	however	RB
cord-015684-q10sx1dm	211	32	,	,	,
cord-015684-q10sx1dm	211	33	from	from	IN
cord-015684-q10sx1dm	211	34	historical	historical	JJ
cord-015684-q10sx1dm	211	35	and	and	CC
cord-015684-q10sx1dm	211	36	didactic	didactic	JJ
cord-015684-q10sx1dm	211	37	reasons	reason	NNS
cord-015684-q10sx1dm	211	38	(	(	-LRB-
cord-015684-q10sx1dm	211	39	until	until	IN
cord-015684-q10sx1dm	211	40	a	a	DT
cord-015684-q10sx1dm	211	41	more	more	RBR
cord-015684-q10sx1dm	211	42	suitable	suitable	JJ
cord-015684-q10sx1dm	211	43	and	and	CC
cord-015684-q10sx1dm	211	44	universal	universal	JJ
cord-015684-q10sx1dm	211	45	defi	defi	NNP
cord-015684-q10sx1dm	211	46	nition	nition	NN
cord-015684-q10sx1dm	211	47	can	can	MD
cord-015684-q10sx1dm	211	48	be	be	VB
cord-015684-q10sx1dm	211	49	established	establish	VBN
cord-015684-q10sx1dm	211	50	)	)	-RRB-
cord-015684-q10sx1dm	211	51	it	-PRON-	PRP
cord-015684-q10sx1dm	211	52	would	would	MD
cord-015684-q10sx1dm	211	53	be	be	VB
cord-015684-q10sx1dm	211	54	preferable	preferable	JJ
cord-015684-q10sx1dm	211	55	to	to	TO
cord-015684-q10sx1dm	211	56	maintain	maintain	VB
cord-015684-q10sx1dm	211	57	the	the	DT
cord-015684-q10sx1dm	211	58	term	term	NN
cord-015684-q10sx1dm	211	59	of	of	IN
cord-015684-q10sx1dm	211	60	pharmacogenetics	pharmacogenetic	NNS
cord-015684-q10sx1dm	211	61	for	for	IN
cord-015684-q10sx1dm	211	62	the	the	DT
cord-015684-q10sx1dm	211	63	discipline	discipline	NN
cord-015684-q10sx1dm	211	64	dealing	deal	VBG
cord-015684-q10sx1dm	211	65	with	with	IN
cord-015684-q10sx1dm	211	66	genetic	genetic	JJ
cord-015684-q10sx1dm	211	67	factors	factor	NNS
cord-015684-q10sx1dm	211	68	associated	associate	VBN
cord-015684-q10sx1dm	211	69	with	with	IN
cord-015684-q10sx1dm	211	70	drug	drug	NN
cord-015684-q10sx1dm	211	71	metabolism	metabolism	NN
cord-015684-q10sx1dm	211	72	and	and	CC
cord-015684-q10sx1dm	211	73	safety	safety	NN
cord-015684-q10sx1dm	211	74	issues	issue	NNS
cord-015684-q10sx1dm	211	75	,	,	,
cord-015684-q10sx1dm	211	76	whereas	whereas	IN
cord-015684-q10sx1dm	211	77	pharmacogenomics	pharmacogenomic	NNS
cord-015684-q10sx1dm	211	78	would	would	MD
cord-015684-q10sx1dm	211	79	refer	refer	VB
cord-015684-q10sx1dm	211	80	to	to	IN
cord-015684-q10sx1dm	211	81	the	the	DT
cord-015684-q10sx1dm	211	82	reciprocal	reciprocal	JJ
cord-015684-q10sx1dm	211	83	infl	infl	NN
cord-015684-q10sx1dm	211	84	uence	uence	NN
cord-015684-q10sx1dm	211	85	of	of	IN
cord-015684-q10sx1dm	211	86	drugs	drug	NNS
cord-015684-q10sx1dm	211	87	and	and	CC
cord-015684-q10sx1dm	211	88	genomic	genomic	JJ
cord-015684-q10sx1dm	211	89	factors	factor	NNS
cord-015684-q10sx1dm	211	90	on	on	IN
cord-015684-q10sx1dm	211	91	pathogenetic	pathogenetic	JJ
cord-015684-q10sx1dm	211	92	cascades	cascade	NNS
cord-015684-q10sx1dm	211	93	and	and	CC
cord-015684-q10sx1dm	211	94	disease	disease	NN
cord-015684-q10sx1dm	211	95	-	-	HYPH
cord-015684-q10sx1dm	211	96	associated	associate	VBN
cord-015684-q10sx1dm	211	97	gene	gene	NN
cord-015684-q10sx1dm	211	98	expression	expression	NN
cord-015684-q10sx1dm	211	99	(	(	-LRB-
cord-015684-q10sx1dm	211	100	effi	effi	NNP
cord-015684-q10sx1dm	211	101	cacy	cacy	NNP
cord-015684-q10sx1dm	211	102	issues	issue	NNS
cord-015684-q10sx1dm	211	103	)	)	-RRB-
cord-015684-q10sx1dm	211	104	.	.	.
cord-015684-q10sx1dm	212	1	[	[	-LRB-
cord-015684-q10sx1dm	212	2	18	18	CD
cord-015684-q10sx1dm	212	3	]	]	-RRB-
cord-015684-q10sx1dm	212	4	[	[	-LRB-
cord-015684-q10sx1dm	212	5	19	19	CD
cord-015684-q10sx1dm	212	6	]	]	-RRB-
cord-015684-q10sx1dm	212	7	[	[	-LRB-
cord-015684-q10sx1dm	212	8	20	20	CD
cord-015684-q10sx1dm	212	9	]	]	-RRB-
cord-015684-q10sx1dm	212	10	[	[	-LRB-
cord-015684-q10sx1dm	212	11	21	21	CD
cord-015684-q10sx1dm	212	12	]	]	-RRB-
cord-015684-q10sx1dm	213	1	[	[	-LRB-
cord-015684-q10sx1dm	213	2	22	22	CD
cord-015684-q10sx1dm	213	3	]	]	-RRB-
cord-015684-q10sx1dm	213	4	[	[	-LRB-
cord-015684-q10sx1dm	213	5	74	74	CD
cord-015684-q10sx1dm	213	6	]	]	-RRB-
cord-015684-q10sx1dm	214	1	[	[	-LRB-
cord-015684-q10sx1dm	214	2	75	75	CD
cord-015684-q10sx1dm	214	3	]	]	-RRB-
cord-015684-q10sx1dm	214	4	[	[	-LRB-
cord-015684-q10sx1dm	214	5	76	76	CD
cord-015684-q10sx1dm	214	6	]	]	-RRB-
cord-015684-q10sx1dm	214	7	[	[	-LRB-
cord-015684-q10sx1dm	214	8	77	77	CD
cord-015684-q10sx1dm	214	9	]	]	-RRB-
cord-015684-q10sx1dm	215	1	The	the	DT
cord-015684-q10sx1dm	215	2	application	application	NN
cord-015684-q10sx1dm	215	3	of	of	IN
cord-015684-q10sx1dm	215	4	these	these	DT
cord-015684-q10sx1dm	215	5	procedures	procedure	NNS
cord-015684-q10sx1dm	215	6	to	to	IN
cord-015684-q10sx1dm	215	7	CNS	CNS	NNP
cord-015684-q10sx1dm	215	8	disorders	disorder	NNS
cord-015684-q10sx1dm	215	9	is	be	VBZ
cord-015684-q10sx1dm	215	10	a	a	DT
cord-015684-q10sx1dm	215	11	very	very	RB
cord-015684-q10sx1dm	215	12	diffi	diffi	JJ
cord-015684-q10sx1dm	215	13	cult	cult	NN
cord-015684-q10sx1dm	215	14	task	task	NN
cord-015684-q10sx1dm	215	15	,	,	,
cord-015684-q10sx1dm	215	16	since	since	IN
cord-015684-q10sx1dm	215	17	most	most	JJS
cord-015684-q10sx1dm	215	18	neuropsychiatric	neuropsychiatric	JJ
cord-015684-q10sx1dm	215	19	diseases	disease	NNS
cord-015684-q10sx1dm	215	20	are	be	VBP
cord-015684-q10sx1dm	215	21	complex	complex	JJ
cord-015684-q10sx1dm	215	22	disorders	disorder	NNS
cord-015684-q10sx1dm	215	23	in	in	IN
cord-015684-q10sx1dm	215	24	which	which	WDT
cord-015684-q10sx1dm	215	25	hundreds	hundred	NNS
cord-015684-q10sx1dm	215	26	of	of	IN
cord-015684-q10sx1dm	215	27	genes	gene	NNS
cord-015684-q10sx1dm	215	28	might	may	MD
cord-015684-q10sx1dm	215	29	be	be	VB
cord-015684-q10sx1dm	215	30	involved	involve	VBN
cord-015684-q10sx1dm	215	31	8	8	CD
cord-015684-q10sx1dm	215	32	,	,	,
cord-015684-q10sx1dm	215	33	[	[	-LRB-
cord-015684-q10sx1dm	215	34	16	16	CD
cord-015684-q10sx1dm	215	35	]	]	-RRB-
cord-015684-q10sx1dm	215	36	[	[	-LRB-
cord-015684-q10sx1dm	215	37	17	17	CD
cord-015684-q10sx1dm	215	38	]	]	-RRB-
cord-015684-q10sx1dm	215	39	[	[	-LRB-
cord-015684-q10sx1dm	215	40	18	18	CD
cord-015684-q10sx1dm	215	41	]	]	-RRB-
cord-015684-q10sx1dm	215	42	[	[	-LRB-
cord-015684-q10sx1dm	215	43	19	19	CD
cord-015684-q10sx1dm	215	44	]	]	-RRB-
cord-015684-q10sx1dm	215	45	[	[	-LRB-
cord-015684-q10sx1dm	215	46	20	20	CD
cord-015684-q10sx1dm	215	47	]	]	-RRB-
cord-015684-q10sx1dm	215	48	[	[	-LRB-
cord-015684-q10sx1dm	215	49	21	21	CD
cord-015684-q10sx1dm	215	50	]	]	-RRB-
cord-015684-q10sx1dm	215	51	[	[	-LRB-
cord-015684-q10sx1dm	215	52	22	22	CD
cord-015684-q10sx1dm	215	53	]	]	-RRB-
cord-015684-q10sx1dm	215	54	[	[	-LRB-
cord-015684-q10sx1dm	215	55	74	74	CD
cord-015684-q10sx1dm	215	56	]	]	-RRB-
cord-015684-q10sx1dm	215	57	[	[	-LRB-
cord-015684-q10sx1dm	215	58	75	75	CD
cord-015684-q10sx1dm	215	59	]	]	-RRB-
cord-015684-q10sx1dm	215	60	[	[	-LRB-
cord-015684-q10sx1dm	215	61	76	76	CD
cord-015684-q10sx1dm	215	62	]	]	-RRB-
cord-015684-q10sx1dm	215	63	[	[	-LRB-
cord-015684-q10sx1dm	215	64	77	77	CD
cord-015684-q10sx1dm	215	65	]	]	-RRB-
cord-015684-q10sx1dm	216	1	(	(	-LRB-
cord-015684-q10sx1dm	216	2	Tables	table	NNS
cord-015684-q10sx1dm	216	3	40.1	40.1	CD
cord-015684-q10sx1dm	216	4	-	-	HYPH
cord-015684-q10sx1dm	216	5	40.3	40.3	CD
cord-015684-q10sx1dm	216	6	)	)	-RRB-
cord-015684-q10sx1dm	216	7	.	.	.
cord-015684-q10sx1dm	217	1	In	in	IN
cord-015684-q10sx1dm	217	2	addition	addition	NN
cord-015684-q10sx1dm	217	3	,	,	,
cord-015684-q10sx1dm	217	4	it	-PRON-	PRP
cord-015684-q10sx1dm	217	5	is	be	VBZ
cord-015684-q10sx1dm	217	6	very	very	RB
cord-015684-q10sx1dm	217	7	unlikely	unlikely	JJ
cord-015684-q10sx1dm	217	8	that	that	IN
cord-015684-q10sx1dm	217	9	a	a	DT
cord-015684-q10sx1dm	217	10	single	single	JJ
cord-015684-q10sx1dm	217	11	drug	drug	NN
cord-015684-q10sx1dm	217	12	be	be	VB
cord-015684-q10sx1dm	217	13	able	able	JJ
cord-015684-q10sx1dm	217	14	to	to	TO
cord-015684-q10sx1dm	217	15	reverse	reverse	VB
cord-015684-q10sx1dm	217	16	the	the	DT
cord-015684-q10sx1dm	217	17	multifactorial	multifactorial	JJ
cord-015684-q10sx1dm	217	18	mechanisms	mechanism	NNS
cord-015684-q10sx1dm	217	19	associated	associate	VBN
cord-015684-q10sx1dm	217	20	with	with	IN
cord-015684-q10sx1dm	217	21	neuronal	neuronal	JJ
cord-015684-q10sx1dm	217	22	dysfunction	dysfunction	NN
cord-015684-q10sx1dm	217	23	in	in	IN
cord-015684-q10sx1dm	217	24	most	most	JJS
cord-015684-q10sx1dm	217	25	CNS	CNS	NNP
cord-015684-q10sx1dm	217	26	processes	process	NNS
cord-015684-q10sx1dm	217	27	with	with	IN
cord-015684-q10sx1dm	217	28	a	a	DT
cord-015684-q10sx1dm	217	29	complex	complex	JJ
cord-015684-q10sx1dm	217	30	phenotype	phenotype	NN
cord-015684-q10sx1dm	217	31	affecting	affect	VBG
cord-015684-q10sx1dm	217	32	mood	mood	NN
cord-015684-q10sx1dm	217	33	,	,	,
cord-015684-q10sx1dm	217	34	personality	personality	NN
cord-015684-q10sx1dm	217	35	,	,	,
cord-015684-q10sx1dm	217	36	behaviour	behaviour	NN
cord-015684-q10sx1dm	217	37	,	,	,
cord-015684-q10sx1dm	217	38	cognition	cognition	NN
cord-015684-q10sx1dm	217	39	,	,	,
cord-015684-q10sx1dm	217	40	and	and	CC
cord-015684-q10sx1dm	217	41	functioning	function	VBG
cord-015684-q10sx1dm	217	42	.	.	.
cord-015684-q10sx1dm	218	1	This	this	DT
cord-015684-q10sx1dm	218	2	heterogeneous	heterogeneous	JJ
cord-015684-q10sx1dm	218	3	clinical	clinical	JJ
cord-015684-q10sx1dm	218	4	picture	picture	NN
cord-015684-q10sx1dm	218	5	usually	usually	RB
cord-015684-q10sx1dm	218	6	requires	require	VBZ
cord-015684-q10sx1dm	218	7	the	the	DT
cord-015684-q10sx1dm	218	8	utilization	utilization	NN
cord-015684-q10sx1dm	218	9	of	of	IN
cord-015684-q10sx1dm	218	10	different	different	JJ
cord-015684-q10sx1dm	218	11	drugs	drug	NNS
cord-015684-q10sx1dm	218	12	administered	administer	VBN
cord-015684-q10sx1dm	218	13	simultaneously	simultaneously	RB
cord-015684-q10sx1dm	218	14	.	.	.
cord-015684-q10sx1dm	219	1	This	this	DT
cord-015684-q10sx1dm	219	2	is	be	VBZ
cord-015684-q10sx1dm	219	3	particularly	particularly	RB
cord-015684-q10sx1dm	219	4	important	important	JJ
cord-015684-q10sx1dm	219	5	in	in	IN
cord-015684-q10sx1dm	219	6	the	the	DT
cord-015684-q10sx1dm	219	7	elderly	elderly	JJ
cord-015684-q10sx1dm	219	8	population	population	NN
cord-015684-q10sx1dm	219	9	.	.	.
cord-015684-q10sx1dm	220	1	In	in	IN
cord-015684-q10sx1dm	220	2	fact	fact	NN
cord-015684-q10sx1dm	220	3	,	,	,
cord-015684-q10sx1dm	220	4	the	the	DT
cord-015684-q10sx1dm	220	5	average	average	JJ
cord-015684-q10sx1dm	220	6	number	number	NN
cord-015684-q10sx1dm	220	7	of	of	IN
cord-015684-q10sx1dm	220	8	drugs	drug	NNS
cord-015684-q10sx1dm	220	9	taken	take	VBN
cord-015684-q10sx1dm	220	10	by	by	IN
cord-015684-q10sx1dm	220	11	patients	patient	NNS
cord-015684-q10sx1dm	220	12	with	with	IN
cord-015684-q10sx1dm	220	13	dementia	dementia	NN
cord-015684-q10sx1dm	220	14	ranges	range	NNS
cord-015684-q10sx1dm	220	15	from	from	IN
cord-015684-q10sx1dm	220	16	six	six	CD
cord-015684-q10sx1dm	220	17	to	to	IN
cord-015684-q10sx1dm	220	18	more	more	JJR
cord-015684-q10sx1dm	220	19	than	than	IN
cord-015684-q10sx1dm	220	20	ten	ten	CD
cord-015684-q10sx1dm	220	21	per	per	IN
cord-015684-q10sx1dm	220	22	day	day	NN
cord-015684-q10sx1dm	220	23	depending	depend	VBG
cord-015684-q10sx1dm	220	24	upon	upon	IN
cord-015684-q10sx1dm	220	25	their	-PRON-	PRP$
cord-015684-q10sx1dm	220	26	physical	physical	JJ
cord-015684-q10sx1dm	220	27	and	and	CC
cord-015684-q10sx1dm	220	28	mental	mental	JJ
cord-015684-q10sx1dm	220	29	conditions	condition	NNS
cord-015684-q10sx1dm	220	30	.	.	.
cord-015684-q10sx1dm	221	1	Nursing	nursing	NN
cord-015684-q10sx1dm	221	2	home	home	NN
cord-015684-q10sx1dm	221	3	residents	resident	NNS
cord-015684-q10sx1dm	221	4	receive	receive	VBP
cord-015684-q10sx1dm	221	5	,	,	,
cord-015684-q10sx1dm	221	6	on	on	IN
cord-015684-q10sx1dm	221	7	average	average	JJ
cord-015684-q10sx1dm	221	8	,	,	,
cord-015684-q10sx1dm	221	9	seven	seven	CD
cord-015684-q10sx1dm	221	10	to	to	TO
cord-015684-q10sx1dm	221	11	eight	eight	CD
cord-015684-q10sx1dm	221	12	medications	medication	NNS
cord-015684-q10sx1dm	221	13	each	each	DT
cord-015684-q10sx1dm	221	14	month	month	NN
cord-015684-q10sx1dm	221	15	,	,	,
cord-015684-q10sx1dm	221	16	and	and	CC
cord-015684-q10sx1dm	221	17	more	more	JJR
cord-015684-q10sx1dm	221	18	than	than	IN
cord-015684-q10sx1dm	221	19	30	30	CD
cord-015684-q10sx1dm	221	20	%	%	NN
cord-015684-q10sx1dm	221	21	of	of	IN
cord-015684-q10sx1dm	221	22	residents	resident	NNS
cord-015684-q10sx1dm	221	23	have	have	VBP
cord-015684-q10sx1dm	221	24	monthly	monthly	JJ
cord-015684-q10sx1dm	221	25	drug	drug	NN
cord-015684-q10sx1dm	221	26	regimes	regime	NNS
cord-015684-q10sx1dm	221	27	of	of	IN
cord-015684-q10sx1dm	221	28	nine	nine	CD
cord-015684-q10sx1dm	221	29	or	or	CC
cord-015684-q10sx1dm	221	30	more	more	JJR
cord-015684-q10sx1dm	221	31	medications	medication	NNS
cord-015684-q10sx1dm	221	32	,	,	,
cord-015684-q10sx1dm	221	33	including	include	VBG
cord-015684-q10sx1dm	221	34	(	(	-LRB-
cord-015684-q10sx1dm	221	35	in	in	IN
cord-015684-q10sx1dm	221	36	descending	descend	VBG
cord-015684-q10sx1dm	221	37	order	order	NN
cord-015684-q10sx1dm	221	38	)	)	-RRB-
cord-015684-q10sx1dm	221	39	analgesics	analgesic	NNS
cord-015684-q10sx1dm	221	40	,	,	,
cord-015684-q10sx1dm	221	41	antipyretics	antipyretic	NNS
cord-015684-q10sx1dm	221	42	,	,	,
cord-015684-q10sx1dm	221	43	gastrointestinal	gastrointestinal	JJ
cord-015684-q10sx1dm	221	44	agents	agent	NNS
cord-015684-q10sx1dm	221	45	,	,	,
cord-015684-q10sx1dm	221	46	electrolytic	electrolytic	JJ
cord-015684-q10sx1dm	221	47	and	and	CC
cord-015684-q10sx1dm	221	48	caloric	caloric	JJ
cord-015684-q10sx1dm	221	49	preparations	preparation	NNS
cord-015684-q10sx1dm	221	50	,	,	,
cord-015684-q10sx1dm	221	51	central	central	JJ
cord-015684-q10sx1dm	221	52	nervous	nervous	JJ
cord-015684-q10sx1dm	221	53	system	system	NN
cord-015684-q10sx1dm	221	54	(	(	-LRB-
cord-015684-q10sx1dm	221	55	CNS	CNS	NNP
cord-015684-q10sx1dm	221	56	)	)	-RRB-
cord-015684-q10sx1dm	221	57	agents	agent	NNS
cord-015684-q10sx1dm	221	58	,	,	,
cord-015684-q10sx1dm	221	59	anti	anti	JJ
cord-015684-q10sx1dm	221	60	-	-	JJ
cord-015684-q10sx1dm	221	61	infective	infective	JJ
cord-015684-q10sx1dm	221	62	agents	agent	NNS
cord-015684-q10sx1dm	221	63	,	,	,
cord-015684-q10sx1dm	221	64	and	and	CC
cord-015684-q10sx1dm	221	65	cardiovascular	cardiovascular	JJ
cord-015684-q10sx1dm	221	66	agents	agent	NNS
cord-015684-q10sx1dm	221	67	.	.	.
cord-015684-q10sx1dm	222	1	81	81	CD
cord-015684-q10sx1dm	223	1	In	in	IN
cord-015684-q10sx1dm	223	2	population	population	NN
cord-015684-q10sx1dm	223	3	-	-	HYPH
cord-015684-q10sx1dm	223	4	based	base	VBN
cord-015684-q10sx1dm	223	5	studies	study	NNS
cord-015684-q10sx1dm	223	6	more	more	JJR
cord-015684-q10sx1dm	223	7	than	than	IN
cord-015684-q10sx1dm	223	8	35	35	CD
cord-015684-q10sx1dm	223	9	%	%	NN
cord-015684-q10sx1dm	223	10	of	of	IN
cord-015684-q10sx1dm	223	11	patients	patient	NNS
cord-015684-q10sx1dm	223	12	older	old	JJR
cord-015684-q10sx1dm	223	13	than	than	IN
cord-015684-q10sx1dm	223	14	85	85	CD
cord-015684-q10sx1dm	223	15	years	year	NNS
cord-015684-q10sx1dm	223	16	are	be	VBP
cord-015684-q10sx1dm	223	17	moderate	moderate	JJ
cord-015684-q10sx1dm	223	18	or	or	CC
cord-015684-q10sx1dm	223	19	chronic	chronic	JJ
cord-015684-q10sx1dm	223	20	antidepressant	antidepressant	JJ
cord-015684-q10sx1dm	223	21	users	user	NNS
cord-015684-q10sx1dm	223	22	.	.	.
cord-015684-q10sx1dm	224	1	82	82	CD
cord-015684-q10sx1dm	224	2	Polypharmacy	Polypharmacy	NNP
cord-015684-q10sx1dm	224	3	,	,	,
cord-015684-q10sx1dm	224	4	drug	drug	NN
cord-015684-q10sx1dm	224	5	-	-	HYPH
cord-015684-q10sx1dm	224	6	drug	drug	NN
cord-015684-q10sx1dm	224	7	interactions	interaction	NNS
cord-015684-q10sx1dm	224	8	,	,	,
cord-015684-q10sx1dm	224	9	adverse	adverse	JJ
cord-015684-q10sx1dm	224	10	reactions	reaction	NNS
cord-015684-q10sx1dm	224	11	,	,	,
cord-015684-q10sx1dm	224	12	and	and	CC
cord-015684-q10sx1dm	224	13	non	non	JJ
cord-015684-q10sx1dm	224	14	-	-	NN
cord-015684-q10sx1dm	224	15	compliance	compliance	NN
cord-015684-q10sx1dm	224	16	are	be	VBP
cord-015684-q10sx1dm	224	17	substantial	substantial	JJ
cord-015684-q10sx1dm	224	18	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	224	19	problems	problem	NNS
cord-015684-q10sx1dm	224	20	in	in	IN
cord-015684-q10sx1dm	224	21	the	the	DT
cord-015684-q10sx1dm	224	22	pharmacological	pharmacological	JJ
cord-015684-q10sx1dm	224	23	management	management	NN
cord-015684-q10sx1dm	224	24	of	of	IN
cord-015684-q10sx1dm	224	25	elderly	elderly	JJ
cord-015684-q10sx1dm	224	26	patients	patient	NNS
cord-015684-q10sx1dm	224	27	,	,	,
cord-015684-q10sx1dm	224	28	83	83	CD
cord-015684-q10sx1dm	224	29	adding	add	VBG
cord-015684-q10sx1dm	224	30	further	further	JJ
cord-015684-q10sx1dm	224	31	complications	complication	NNS
cord-015684-q10sx1dm	224	32	and	and	CC
cord-015684-q10sx1dm	224	33	costs	cost	NNS
cord-015684-q10sx1dm	224	34	to	to	IN
cord-015684-q10sx1dm	224	35	the	the	DT
cord-015684-q10sx1dm	224	36	patients	patient	NNS
cord-015684-q10sx1dm	224	37	and	and	CC
cord-015684-q10sx1dm	224	38	their	-PRON-	PRP$
cord-015684-q10sx1dm	224	39	caregivers	caregiver	NNS
cord-015684-q10sx1dm	224	40	.	.	.
cord-015684-q10sx1dm	225	1	In	in	IN
cord-015684-q10sx1dm	225	2	2000	2000	CD
cord-015684-q10sx1dm	225	3	-	-	SYM
cord-015684-q10sx1dm	225	4	2001	2001	CD
cord-015684-q10sx1dm	225	5	,	,	,
cord-015684-q10sx1dm	225	6	23.0	23.0	CD
cord-015684-q10sx1dm	225	7	-	-	HYPH
cord-015684-q10sx1dm	225	8	36.5	36.5	CD
cord-015684-q10sx1dm	225	9	%	%	NN
cord-015684-q10sx1dm	225	10	of	of	IN
cord-015684-q10sx1dm	225	11	elderly	elderly	JJ
cord-015684-q10sx1dm	225	12	individuals	individual	NNS
cord-015684-q10sx1dm	225	13	received	receive	VBD
cord-015684-q10sx1dm	225	14	at	at	IN
cord-015684-q10sx1dm	225	15	least	least	JJS
cord-015684-q10sx1dm	225	16	1	1	CD
cord-015684-q10sx1dm	225	17	of	of	IN
cord-015684-q10sx1dm	225	18	33	33	CD
cord-015684-q10sx1dm	225	19	potentially	potentially	RB
cord-015684-q10sx1dm	225	20	inappropriate	inappropriate	JJ
cord-015684-q10sx1dm	225	21	medications	medication	NNS
cord-015684-q10sx1dm	225	22	in	in	IN
cord-015684-q10sx1dm	225	23	ten	ten	CD
cord-015684-q10sx1dm	225	24	health	health	NN
cord-015684-q10sx1dm	225	25	maintenance	maintenance	NN
cord-015684-q10sx1dm	225	26	organizations	organization	NNS
cord-015684-q10sx1dm	225	27	(	(	-LRB-
cord-015684-q10sx1dm	225	28	HMOs	hmo	NNS
cord-015684-q10sx1dm	225	29	)	)	-RRB-
cord-015684-q10sx1dm	225	30	of	of	IN
cord-015684-q10sx1dm	225	31	the	the	DT
cord-015684-q10sx1dm	225	32	USA	USA	NNP
cord-015684-q10sx1dm	225	33	.	.	.
cord-015684-q10sx1dm	226	1	84	84	CD
cord-015684-q10sx1dm	227	1	Although	although	IN
cord-015684-q10sx1dm	227	2	drug	drug	NN
cord-015684-q10sx1dm	227	3	effect	effect	NN
cord-015684-q10sx1dm	227	4	is	be	VBZ
cord-015684-q10sx1dm	227	5	a	a	DT
cord-015684-q10sx1dm	227	6	complex	complex	JJ
cord-015684-q10sx1dm	227	7	phenotype	phenotype	NN
cord-015684-q10sx1dm	227	8	that	that	WDT
cord-015684-q10sx1dm	227	9	depends	depend	VBZ
cord-015684-q10sx1dm	227	10	on	on	IN
cord-015684-q10sx1dm	227	11	many	many	JJ
cord-015684-q10sx1dm	227	12	factors	factor	NNS
cord-015684-q10sx1dm	227	13	,	,	,
cord-015684-q10sx1dm	227	14	it	-PRON-	PRP
cord-015684-q10sx1dm	227	15	is	be	VBZ
cord-015684-q10sx1dm	227	16	estimated	estimate	VBN
cord-015684-q10sx1dm	227	17	that	that	IN
cord-015684-q10sx1dm	227	18	genetics	genetics	NN
cord-015684-q10sx1dm	227	19	accounts	account	VBZ
cord-015684-q10sx1dm	227	20	for	for	IN
cord-015684-q10sx1dm	227	21	20	20	CD
cord-015684-q10sx1dm	227	22	-	-	SYM
cord-015684-q10sx1dm	227	23	95	95	CD
cord-015684-q10sx1dm	227	24	%	%	NN
cord-015684-q10sx1dm	227	25	of	of	IN
cord-015684-q10sx1dm	227	26	variability	variability	NN
cord-015684-q10sx1dm	227	27	in	in	IN
cord-015684-q10sx1dm	227	28	drug	drug	NN
cord-015684-q10sx1dm	227	29	disposition	disposition	NN
cord-015684-q10sx1dm	227	30	and	and	CC
cord-015684-q10sx1dm	227	31	pharmacodynamics	pharmacodynamic	NNS
cord-015684-q10sx1dm	227	32	.	.	.
cord-015684-q10sx1dm	228	1	79	79	CD
cord-015684-q10sx1dm	228	2	Under	under	IN
cord-015684-q10sx1dm	228	3	these	these	DT
cord-015684-q10sx1dm	228	4	circumstances	circumstance	NNS
cord-015684-q10sx1dm	228	5	,	,	,
cord-015684-q10sx1dm	228	6	therapeutics	therapeutic	NNS
cord-015684-q10sx1dm	228	7	optimization	optimization	NN
cord-015684-q10sx1dm	228	8	is	be	VBZ
cord-015684-q10sx1dm	228	9	a	a	DT
cord-015684-q10sx1dm	228	10	major	major	JJ
cord-015684-q10sx1dm	228	11	goal	goal	NN
cord-015684-q10sx1dm	228	12	in	in	IN
cord-015684-q10sx1dm	228	13	neuropsychiatric	neuropsychiatric	JJ
cord-015684-q10sx1dm	228	14	disorders	disorder	NNS
cord-015684-q10sx1dm	228	15	and	and	CC
cord-015684-q10sx1dm	228	16	in	in	IN
cord-015684-q10sx1dm	228	17	the	the	DT
cord-015684-q10sx1dm	228	18	elderly	elderly	JJ
cord-015684-q10sx1dm	228	19	population	population	NN
cord-015684-q10sx1dm	228	20	,	,	,
cord-015684-q10sx1dm	228	21	and	and	CC
cord-015684-q10sx1dm	228	22	novel	novel	NN
cord-015684-q10sx1dm	228	23	pharmacogenetic	pharmacogenetic	NN
cord-015684-q10sx1dm	228	24	and	and	CC
cord-015684-q10sx1dm	228	25	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	228	26	procedures	procedure	NNS
cord-015684-q10sx1dm	228	27	may	may	MD
cord-015684-q10sx1dm	228	28	help	help	VB
cord-015684-q10sx1dm	228	29	in	in	IN
cord-015684-q10sx1dm	228	30	this	this	DT
cord-015684-q10sx1dm	228	31	endeavour	endeavour	NN
cord-015684-q10sx1dm	228	32	.	.	.
cord-015684-q10sx1dm	229	1	[	[	-LRB-
cord-015684-q10sx1dm	229	2	16	16	CD
cord-015684-q10sx1dm	229	3	]	]	-RRB-
cord-015684-q10sx1dm	229	4	[	[	-LRB-
cord-015684-q10sx1dm	229	5	17	17	CD
cord-015684-q10sx1dm	229	6	]	]	-RRB-
cord-015684-q10sx1dm	229	7	[	[	-LRB-
cord-015684-q10sx1dm	229	8	18	18	CD
cord-015684-q10sx1dm	229	9	]	]	-RRB-
cord-015684-q10sx1dm	229	10	[	[	-LRB-
cord-015684-q10sx1dm	229	11	19	19	CD
cord-015684-q10sx1dm	229	12	]	]	-RRB-
cord-015684-q10sx1dm	230	1	[	[	-LRB-
cord-015684-q10sx1dm	230	2	20	20	CD
cord-015684-q10sx1dm	230	3	]	]	-RRB-
cord-015684-q10sx1dm	230	4	[	[	-LRB-
cord-015684-q10sx1dm	230	5	21	21	CD
cord-015684-q10sx1dm	230	6	]	]	-RRB-
cord-015684-q10sx1dm	231	1	[	[	-LRB-
cord-015684-q10sx1dm	231	2	22	22	CD
cord-015684-q10sx1dm	231	3	]	]	-RRB-
cord-015684-q10sx1dm	231	4	[	[	-LRB-
cord-015684-q10sx1dm	231	5	74	74	CD
cord-015684-q10sx1dm	231	6	]	]	-RRB-
cord-015684-q10sx1dm	232	1	[	[	-LRB-
cord-015684-q10sx1dm	232	2	75	75	CD
cord-015684-q10sx1dm	232	3	]	]	-RRB-
cord-015684-q10sx1dm	232	4	[	[	-LRB-
cord-015684-q10sx1dm	232	5	76	76	CD
cord-015684-q10sx1dm	232	6	]	]	-RRB-
cord-015684-q10sx1dm	233	1	[	[	-LRB-
cord-015684-q10sx1dm	233	2	77	77	CD
cord-015684-q10sx1dm	233	3	]	]	-RRB-
cord-015684-q10sx1dm	233	4	 	 	_SP
cord-015684-q10sx1dm	234	1	The	the	DT
cord-015684-q10sx1dm	234	2	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	234	3	outcome	outcome	NN
cord-015684-q10sx1dm	234	4	depends	depend	VBZ
cord-015684-q10sx1dm	234	5	upon	upon	IN
cord-015684-q10sx1dm	234	6	many	many	JJ
cord-015684-q10sx1dm	234	7	different	different	JJ
cord-015684-q10sx1dm	234	8	determinant	determinant	NN
cord-015684-q10sx1dm	234	9	factors	factor	NNS
cord-015684-q10sx1dm	234	10	including	include	VBG
cord-015684-q10sx1dm	234	11	(	(	-LRB-
cord-015684-q10sx1dm	234	12	i	i	NN
cord-015684-q10sx1dm	234	13	)	)	-RRB-
cord-015684-q10sx1dm	234	14	genomic	genomic	JJ
cord-015684-q10sx1dm	234	15	profi	profi	NNP
cord-015684-q10sx1dm	234	16	le	le	NNP
cord-015684-q10sx1dm	234	17	(	(	-LRB-
cord-015684-q10sx1dm	234	18	family	family	NN
cord-015684-q10sx1dm	234	19	history	history	NN
cord-015684-q10sx1dm	234	20	,	,	,
cord-015684-q10sx1dm	234	21	ethnic	ethnic	JJ
cord-015684-q10sx1dm	234	22	background	background	NN
cord-015684-q10sx1dm	234	23	,	,	,
cord-015684-q10sx1dm	234	24	disease	disease	NN
cord-015684-q10sx1dm	234	25	-	-	HYPH
cord-015684-q10sx1dm	234	26	related	relate	VBN
cord-015684-q10sx1dm	234	27	genotype	genotype	NN
cord-015684-q10sx1dm	234	28	,	,	,
cord-015684-q10sx1dm	234	29	pharmacogenetic	pharmacogenetic	JJ
cord-015684-q10sx1dm	234	30	genotype	genotype	NN
cord-015684-q10sx1dm	234	31	,	,	,
cord-015684-q10sx1dm	234	32	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	234	33	genotype	genotype	NN
cord-015684-q10sx1dm	234	34	,	,	,
cord-015684-q10sx1dm	234	35	nutrigenetic	nutrigenetic	JJ
cord-015684-q10sx1dm	234	36	genotype	genotype	NN
cord-015684-q10sx1dm	234	37	,	,	,
cord-015684-q10sx1dm	234	38	nutrigenomic	nutrigenomic	NNP
cord-015684-q10sx1dm	234	39	genotype	genotype	NNP
cord-015684-q10sx1dm	234	40	)	)	-RRB-
cord-015684-q10sx1dm	234	41	,	,	,
cord-015684-q10sx1dm	234	42	(	(	-LRB-
cord-015684-q10sx1dm	234	43	ii	ii	NN
cord-015684-q10sx1dm	234	44	)	)	-RRB-
cord-015684-q10sx1dm	234	45	disease	disease	NN
cord-015684-q10sx1dm	234	46	phenotype	phenotype	NN
cord-015684-q10sx1dm	234	47	(	(	-LRB-
cord-015684-q10sx1dm	234	48	age	age	NN
cord-015684-q10sx1dm	234	49	at	at	IN
cord-015684-q10sx1dm	234	50	onset	onset	NN
cord-015684-q10sx1dm	234	51	,	,	,
cord-015684-q10sx1dm	234	52	disease	disease	NN
cord-015684-q10sx1dm	234	53	severity	severity	NN
cord-015684-q10sx1dm	234	54	,	,	,
cord-015684-q10sx1dm	234	55	clinical	clinical	JJ
cord-015684-q10sx1dm	234	56	symptoms	symptom	NNS
cord-015684-q10sx1dm	234	57	)	)	-RRB-
cord-015684-q10sx1dm	234	58	,	,	,
cord-015684-q10sx1dm	234	59	(	(	-LRB-
cord-015684-q10sx1dm	234	60	iii	iii	NN
cord-015684-q10sx1dm	234	61	)	)	-RRB-
cord-015684-q10sx1dm	235	1	concomitant	concomitant	JJ
cord-015684-q10sx1dm	235	2	pathology	pathology	NN
cord-015684-q10sx1dm	235	3	,	,	,
cord-015684-q10sx1dm	235	4	(	(	-LRB-
cord-015684-q10sx1dm	235	5	iv	iv	LS
cord-015684-q10sx1dm	235	6	)	)	-RRB-
cord-015684-q10sx1dm	235	7	genotype	genotype	NN
cord-015684-q10sx1dm	235	8	-	-	HYPH
cord-015684-q10sx1dm	235	9	phenotype	phenotype	NN
cord-015684-q10sx1dm	235	10	correlations	correlation	NNS
cord-015684-q10sx1dm	235	11	,	,	,
cord-015684-q10sx1dm	235	12	(	(	-LRB-
cord-015684-q10sx1dm	235	13	v	v	LS
cord-015684-q10sx1dm	235	14	)	)	-RRB-
cord-015684-q10sx1dm	235	15	nutritional	nutritional	JJ
cord-015684-q10sx1dm	235	16	conditions	condition	NNS
cord-015684-q10sx1dm	235	17	,	,	,
cord-015684-q10sx1dm	235	18	(	(	-LRB-
cord-015684-q10sx1dm	235	19	vi	vi	NNP
cord-015684-q10sx1dm	235	20	)	)	-RRB-
cord-015684-q10sx1dm	235	21	age	age	NN
cord-015684-q10sx1dm	235	22	and	and	CC
cord-015684-q10sx1dm	235	23	gender	gender	NN
cord-015684-q10sx1dm	235	24	,	,	,
cord-015684-q10sx1dm	235	25	(	(	-LRB-
cord-015684-q10sx1dm	235	26	vii	vii	NN
cord-015684-q10sx1dm	235	27	)	)	-RRB-
cord-015684-q10sx1dm	236	1	pharmacological	pharmacological	JJ
cord-015684-q10sx1dm	236	2	profi	profi	NNP
cord-015684-q10sx1dm	236	3	le	le	NNP
cord-015684-q10sx1dm	236	4	of	of	IN
cord-015684-q10sx1dm	236	5	the	the	DT
cord-015684-q10sx1dm	236	6	drugs	drug	NNS
cord-015684-q10sx1dm	236	7	,	,	,
cord-015684-q10sx1dm	236	8	(	(	-LRB-
cord-015684-q10sx1dm	236	9	viii	viii	NNP
cord-015684-q10sx1dm	236	10	)	)	-RRB-
cord-015684-q10sx1dm	236	11	drug	drug	NN
cord-015684-q10sx1dm	236	12	-	-	HYPH
cord-015684-q10sx1dm	236	13	drug	drug	NN
cord-015684-q10sx1dm	236	14	interactions	interaction	NNS
cord-015684-q10sx1dm	236	15	,	,	,
cord-015684-q10sx1dm	236	16	(	(	-LRB-
cord-015684-q10sx1dm	236	17	ix	ix	LS
cord-015684-q10sx1dm	236	18	)	)	-RRB-
cord-015684-q10sx1dm	236	19	gene	gene	NN
cord-015684-q10sx1dm	236	20	expression	expression	NN
cord-015684-q10sx1dm	236	21	profi	profi	NNP
cord-015684-q10sx1dm	236	22	le	le	NNP
cord-015684-q10sx1dm	236	23	,	,	,
cord-015684-q10sx1dm	236	24	(	(	-LRB-
cord-015684-q10sx1dm	236	25	x	x	LS
cord-015684-q10sx1dm	236	26	)	)	-RRB-
cord-015684-q10sx1dm	236	27	transcriptomic	transcriptomic	NNP
cord-015684-q10sx1dm	236	28	cascade	cascade	NN
cord-015684-q10sx1dm	236	29	,	,	,
cord-015684-q10sx1dm	236	30	(	(	-LRB-
cord-015684-q10sx1dm	236	31	xi	xi	NNP
cord-015684-q10sx1dm	236	32	)	)	-RRB-
cord-015684-q10sx1dm	236	33	proteomic	proteomic	JJ
cord-015684-q10sx1dm	236	34	profi	profi	NNP
cord-015684-q10sx1dm	236	35	le	le	NNP
cord-015684-q10sx1dm	236	36	,	,	,
cord-015684-q10sx1dm	236	37	and	and	CC
cord-015684-q10sx1dm	236	38	(	(	-LRB-
cord-015684-q10sx1dm	236	39	xii	xii	NNP
cord-015684-q10sx1dm	236	40	)	)	-RRB-
cord-015684-q10sx1dm	236	41	metabolomic	metabolomic	JJ
cord-015684-q10sx1dm	236	42	networking	networking	NN
cord-015684-q10sx1dm	236	43	(	(	-LRB-
cord-015684-q10sx1dm	236	44	Fig	Fig	NNP
cord-015684-q10sx1dm	236	45	.	.	.
cord-015684-q10sx1dm	236	46	40.7	40.7	CD
cord-015684-q10sx1dm	236	47	)	)	-RRB-
cord-015684-q10sx1dm	236	48	.	.	.
cord-015684-q10sx1dm	237	1	The	the	DT
cord-015684-q10sx1dm	237	2	dissection	dissection	NN
cord-015684-q10sx1dm	237	3	and	and	CC
cord-015684-q10sx1dm	237	4	further	further	JJ
cord-015684-q10sx1dm	237	5	integration	integration	NN
cord-015684-q10sx1dm	237	6	of	of	IN
cord-015684-q10sx1dm	237	7	all	all	PDT
cord-015684-q10sx1dm	237	8	these	these	DT
cord-015684-q10sx1dm	237	9	factors	factor	NNS
cord-015684-q10sx1dm	237	10	is	be	VBZ
cord-015684-q10sx1dm	237	11	of	of	IN
cord-015684-q10sx1dm	237	12	paramount	paramount	JJ
cord-015684-q10sx1dm	237	13	importance	importance	NN
cord-015684-q10sx1dm	237	14	for	for	IN
cord-015684-q10sx1dm	237	15	the	the	DT
cord-015684-q10sx1dm	237	16	assessment	assessment	NN
cord-015684-q10sx1dm	237	17	of	of	IN
cord-015684-q10sx1dm	237	18	the	the	DT
cord-015684-q10sx1dm	237	19	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	237	20	outcome	outcome	NN
cord-015684-q10sx1dm	237	21	in	in	IN
cord-015684-q10sx1dm	237	22	terms	term	NNS
cord-015684-q10sx1dm	237	23	of	of	IN
cord-015684-q10sx1dm	237	24	safety	safety	NN
cord-015684-q10sx1dm	237	25	and	and	CC
cord-015684-q10sx1dm	237	26	effi	effi	NNP
cord-015684-q10sx1dm	237	27	cacy	cacy	NNP
cord-015684-q10sx1dm	237	28	(	(	-LRB-
cord-015684-q10sx1dm	237	29	Figs	Figs	NNP
cord-015684-q10sx1dm	237	30	.	.	.
cord-015684-q10sx1dm	237	31	40.8	40.8	CD
cord-015684-q10sx1dm	237	32	and	and	CC
cord-015684-q10sx1dm	237	33	40.9	40.9	CD
cord-015684-q10sx1dm	237	34	)	)	-RRB-
cord-015684-q10sx1dm	237	35	.	.	.
cord-015684-q10sx1dm	237	36	 	 	_SP
cord-015684-q10sx1dm	238	1	More	More	JJR
cord-015684-q10sx1dm	238	2	than	than	IN
cord-015684-q10sx1dm	238	3	80	80	CD
cord-015684-q10sx1dm	238	4	%	%	NN
cord-015684-q10sx1dm	238	5	of	of	IN
cord-015684-q10sx1dm	238	6	psychotropic	psychotropic	JJ
cord-015684-q10sx1dm	238	7	drugs	drug	NNS
cord-015684-q10sx1dm	238	8	(	(	-LRB-
cord-015684-q10sx1dm	238	9	Table	table	NN
cord-015684-q10sx1dm	238	10	40	40	CD
cord-015684-q10sx1dm	238	11	.5	.5	NFP
cord-015684-q10sx1dm	238	12	)	)	-RRB-
cord-015684-q10sx1dm	238	13	are	be	VBP
cord-015684-q10sx1dm	238	14	metabolized	metabolize	VBN
cord-015684-q10sx1dm	238	15	by	by	IN
cord-015684-q10sx1dm	238	16	enzymes	enzyme	NNS
cord-015684-q10sx1dm	238	17	known	know	VBN
cord-015684-q10sx1dm	238	18	to	to	TO
cord-015684-q10sx1dm	238	19	be	be	VB
cord-015684-q10sx1dm	238	20	genetically	genetically	RB
cord-015684-q10sx1dm	238	21	variable	variable	JJ
cord-015684-q10sx1dm	238	22	,	,	,
cord-015684-q10sx1dm	238	23	including	include	VBG
cord-015684-q10sx1dm	238	24	:	:	:
cord-015684-q10sx1dm	238	25	(	(	-LRB-
cord-015684-q10sx1dm	238	26	a	a	LS
cord-015684-q10sx1dm	238	27	)	)	-RRB-
cord-015684-q10sx1dm	238	28	esterases	esterase	NNS
cord-015684-q10sx1dm	238	29	:	:	:
cord-015684-q10sx1dm	238	30	butyrylcholinesterase	butyrylcholinesterase	NNP
cord-015684-q10sx1dm	238	31	,	,	,
cord-015684-q10sx1dm	238	32	paraoxonase	paraoxonase	NN
cord-015684-q10sx1dm	238	33	/	/	SYM
cord-015684-q10sx1dm	238	34	arylesterase	arylesterase	NN
cord-015684-q10sx1dm	238	35	;	;	,
cord-015684-q10sx1dm	238	36	(	(	-LRB-
cord-015684-q10sx1dm	238	37	b	b	NN
cord-015684-q10sx1dm	238	38	)	)	-RRB-
cord-015684-q10sx1dm	238	39	transferases	transferase	NNS
cord-015684-q10sx1dm	238	40	:	:	:
cord-015684-q10sx1dm	238	41	N	n	CD
cord-015684-q10sx1dm	238	42	-	-	HYPH
cord-015684-q10sx1dm	238	43	acetyltransferase	acetyltransferase	NNP
cord-015684-q10sx1dm	238	44	,	,	,
cord-015684-q10sx1dm	238	45	sulfotransferase	sulfotransferase	NNP
cord-015684-q10sx1dm	238	46	,	,	,
cord-015684-q10sx1dm	238	47	thiol	thiol	NN
cord-015684-q10sx1dm	238	48	methyltransferase	methyltransferase	NN
cord-015684-q10sx1dm	238	49	,	,	,
cord-015684-q10sx1dm	238	50	thiopurine	thiopurine	NN
cord-015684-q10sx1dm	238	51	methyltransferase	methyltransferase	NN
cord-015684-q10sx1dm	238	52	,	,	,
cord-015684-q10sx1dm	238	53	catechol	catechol	NN
cord-015684-q10sx1dm	238	54	-	-	HYPH
cord-015684-q10sx1dm	238	55	O	o	NN
cord-015684-q10sx1dm	238	56	-	-	HYPH
cord-015684-q10sx1dm	238	57	methyltransferase	methyltransferase	NN
cord-015684-q10sx1dm	238	58	,	,	,
cord-015684-q10sx1dm	238	59	glutathione	glutathione	NN
cord-015684-q10sx1dm	238	60	-	-	HYPH
cord-015684-q10sx1dm	238	61	S	s	NN
cord-015684-q10sx1dm	238	62	-	-	HYPH
cord-015684-q10sx1dm	238	63	transferases	transferase	NNS
cord-015684-q10sx1dm	238	64	,	,	,
cord-015684-q10sx1dm	238	65	UDP	udp	NN
cord-015684-q10sx1dm	238	66	-	-	HYPH
cord-015684-q10sx1dm	238	67	glucuronosyltransferases	glucuronosyltransferase	NNS
cord-015684-q10sx1dm	238	68	,	,	,
cord-015684-q10sx1dm	238	69	glucosyltransferase	glucosyltransferase	NN
cord-015684-q10sx1dm	238	70	,	,	,
cord-015684-q10sx1dm	238	71	histamine	histamine	NN
cord-015684-q10sx1dm	238	72	methyltransferase	methyltransferase	NN
cord-015684-q10sx1dm	238	73	;	;	.
cord-015684-q10sx1dm	239	1	(	(	-LRB-
cord-015684-q10sx1dm	239	2	c	c	NN
cord-015684-q10sx1dm	239	3	)	)	-RRB-
cord-015684-q10sx1dm	239	4	Reductases	Reductases	NNP
cord-015684-q10sx1dm	239	5	:	:	:
cord-015684-q10sx1dm	239	6	NADPH	nadph	NN
cord-015684-q10sx1dm	239	7	:	:	:
cord-015684-q10sx1dm	239	8	quinine	quinine	NN
cord-015684-q10sx1dm	239	9	oxidoreductase	oxidoreductase	NN
cord-015684-q10sx1dm	239	10	,	,	,
cord-015684-q10sx1dm	239	11	glucose-6-phosphate	glucose-6-phosphate	JJ
cord-015684-q10sx1dm	239	12	dehydrogenase	dehydrogenase	NN
cord-015684-q10sx1dm	239	13	;	;	,
cord-015684-q10sx1dm	239	14	(	(	-LRB-
cord-015684-q10sx1dm	239	15	d	d	NN
cord-015684-q10sx1dm	239	16	)	)	-RRB-
cord-015684-q10sx1dm	239	17	oxidases	oxidase	NNS
cord-015684-q10sx1dm	239	18	:	:	:
cord-015684-q10sx1dm	239	19	alcohol	alcohol	NN
cord-015684-q10sx1dm	239	20	dehydrogenase	dehydrogenase	NN
cord-015684-q10sx1dm	239	21	,	,	,
cord-015684-q10sx1dm	239	22	aldehydehydrogenase	aldehydehydrogenase	NN
cord-015684-q10sx1dm	239	23	,	,	,
cord-015684-q10sx1dm	239	24	monoamine	monoamine	NN
cord-015684-q10sx1dm	239	25	oxidase	oxidase	NN
cord-015684-q10sx1dm	239	26	B	b	NN
cord-015684-q10sx1dm	239	27	,	,	,
cord-015684-q10sx1dm	239	28	catalase	catalase	NN
cord-015684-q10sx1dm	239	29	,	,	,
cord-015684-q10sx1dm	239	30	superoxide	superoxide	NN
cord-015684-q10sx1dm	239	31	dismutase	dismutase	NN
cord-015684-q10sx1dm	239	32	,	,	,
cord-015684-q10sx1dm	239	33	trimethylamine	trimethylamine	NN
cord-015684-q10sx1dm	239	34	N	n	CD
cord-015684-q10sx1dm	239	35	-	-	HYPH
cord-015684-q10sx1dm	239	36	oxidase	oxidase	NN
cord-015684-q10sx1dm	239	37	,	,	,
cord-015684-q10sx1dm	239	38	dihydropyrimidine	dihydropyrimidine	JJ
cord-015684-q10sx1dm	239	39	dehydrogenase	dehydrogenase	NN
cord-015684-q10sx1dm	239	40	;	;	:
cord-015684-q10sx1dm	239	41	and	and	CC
cord-015684-q10sx1dm	239	42	(	(	-LRB-
cord-015684-q10sx1dm	239	43	e	e	LS
cord-015684-q10sx1dm	239	44	)	)	-RRB-
cord-015684-q10sx1dm	239	45	cytochrome	cytochrome	JJ
cord-015684-q10sx1dm	239	46	P450	p450	JJ
cord-015684-q10sx1dm	239	47	enzymes	enzyme	NNS
cord-015684-q10sx1dm	239	48	,	,	,
cord-015684-q10sx1dm	239	49	such	such	JJ
cord-015684-q10sx1dm	239	50	as	as	IN
cord-015684-q10sx1dm	239	51	CYP1A1	CYP1A1	NNP
cord-015684-q10sx1dm	239	52	,	,	,
cord-015684-q10sx1dm	239	53	CYP2A6	CYP2A6	NNP
cord-015684-q10sx1dm	239	54	,	,	,
cord-015684-q10sx1dm	239	55	CYP2C8	CYP2C8	NNP
cord-015684-q10sx1dm	239	56	,	,	,
cord-015684-q10sx1dm	239	57	CYP2C9	CYP2C9	NNP
cord-015684-q10sx1dm	239	58	,	,	,
cord-015684-q10sx1dm	239	59	CYP2C19	CYP2C19	NNP
cord-015684-q10sx1dm	239	60	,	,	,
cord-015684-q10sx1dm	239	61	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	239	62	,	,	,
cord-015684-q10sx1dm	239	63	CYP2E1	CYP2E1	NNP
cord-015684-q10sx1dm	239	64	,	,	,
cord-015684-q10sx1dm	239	65	CYP3A5	CYP3A5	NNP
cord-015684-q10sx1dm	239	66	(	(	-LRB-
cord-015684-q10sx1dm	239	67	Table	table	NN
cord-015684-q10sx1dm	239	68	40	40	CD
cord-015684-q10sx1dm	239	69	.6	.6	CD
cord-015684-q10sx1dm	239	70	)	)	-RRB-
cord-015684-q10sx1dm	239	71	and	and	CC
cord-015684-q10sx1dm	239	72	many	many	JJ
cord-015684-q10sx1dm	239	73	others	other	NNS
cord-015684-q10sx1dm	239	74	.	.	.
cord-015684-q10sx1dm	240	1	19	19	CD
cord-015684-q10sx1dm	240	2	,	,	,
cord-015684-q10sx1dm	240	3	20	20	CD
cord-015684-q10sx1dm	240	4	Polymorphic	polymorphic	JJ
cord-015684-q10sx1dm	240	5	variants	variant	NNS
cord-015684-q10sx1dm	240	6	in	in	IN
cord-015684-q10sx1dm	240	7	these	these	DT
cord-015684-q10sx1dm	240	8	genes	gene	NNS
cord-015684-q10sx1dm	240	9	can	can	MD
cord-015684-q10sx1dm	240	10	induce	induce	VB
cord-015684-q10sx1dm	240	11	alterations	alteration	NNS
cord-015684-q10sx1dm	240	12	in	in	IN
cord-015684-q10sx1dm	240	13	drug	drug	NN
cord-015684-q10sx1dm	240	14	metabolism	metabolism	NN
cord-015684-q10sx1dm	240	15	modifying	modify	VBG
cord-015684-q10sx1dm	240	16	the	the	DT
cord-015684-q10sx1dm	240	17	effi	effi	NNP
cord-015684-q10sx1dm	240	18	cacy	cacy	NNP
cord-015684-q10sx1dm	240	19	and	and	CC
cord-015684-q10sx1dm	240	20	safety	safety	NN
cord-015684-q10sx1dm	240	21	of	of	IN
cord-015684-q10sx1dm	240	22	the	the	DT
cord-015684-q10sx1dm	240	23	prescribed	prescribed	JJ
cord-015684-q10sx1dm	240	24	drugs	drug	NNS
cord-015684-q10sx1dm	240	25	.	.	.
cord-015684-q10sx1dm	241	1	85	85	CD
cord-015684-q10sx1dm	241	2	Drug	drug	NN
cord-015684-q10sx1dm	241	3	metabolism	metabolism	NN
cord-015684-q10sx1dm	241	4	includes	include	VBZ
cord-015684-q10sx1dm	241	5	phase	phase	NN
cord-015684-q10sx1dm	242	1	I	-PRON-	PRP
cord-015684-q10sx1dm	242	2	reactions	reaction	NNS
cord-015684-q10sx1dm	242	3	(	(	-LRB-
cord-015684-q10sx1dm	242	4	i.e.	i.e.	FW
cord-015684-q10sx1dm	242	5	,	,	,
cord-015684-q10sx1dm	242	6	oxidation	oxidation	NN
cord-015684-q10sx1dm	242	7	,	,	,
cord-015684-q10sx1dm	242	8	reduction	reduction	NN
cord-015684-q10sx1dm	242	9	,	,	,
cord-015684-q10sx1dm	242	10	hydrolysis	hydrolysis	NN
cord-015684-q10sx1dm	242	11	)	)	-RRB-
cord-015684-q10sx1dm	242	12	and	and	CC
cord-015684-q10sx1dm	242	13	phase	phase	NN
cord-015684-q10sx1dm	242	14	II	ii	CD
cord-015684-q10sx1dm	242	15	conjugation	conjugation	NN
cord-015684-q10sx1dm	242	16	reactions	reaction	NNS
cord-015684-q10sx1dm	242	17	(	(	-LRB-
cord-015684-q10sx1dm	242	18	i.e.	i.e.	FW
cord-015684-q10sx1dm	242	19	,	,	,
cord-015684-q10sx1dm	242	20	acetylation	acetylation	NN
cord-015684-q10sx1dm	242	21	,	,	,
cord-015684-q10sx1dm	242	22	glucuronidation	glucuronidation	NN
cord-015684-q10sx1dm	242	23	,	,	,
cord-015684-q10sx1dm	242	24	sulfation	sulfation	NN
cord-015684-q10sx1dm	242	25	,	,	,
cord-015684-q10sx1dm	242	26	methylation	methylation	NNP
cord-015684-q10sx1dm	242	27	)	)	-RRB-
cord-015684-q10sx1dm	242	28	.	.	.
cord-015684-q10sx1dm	243	1	80	80	CD
cord-015684-q10sx1dm	244	1	The	the	DT
cord-015684-q10sx1dm	244	2	principal	principal	JJ
cord-015684-q10sx1dm	244	3	enzymes	enzyme	NNS
cord-015684-q10sx1dm	244	4	with	with	IN
cord-015684-q10sx1dm	244	5	polymorphic	polymorphic	JJ
cord-015684-q10sx1dm	244	6	variants	variant	NNS
cord-015684-q10sx1dm	244	7	involved	involve	VBN
cord-015684-q10sx1dm	244	8	in	in	IN
cord-015684-q10sx1dm	244	9	phase	phase	NN
cord-015684-q10sx1dm	244	10	I	-PRON-	PRP
cord-015684-q10sx1dm	244	11	reactions	reaction	NNS
cord-015684-q10sx1dm	244	12	are	be	VBP
cord-015684-q10sx1dm	244	13	the	the	DT
cord-015684-q10sx1dm	244	14	following	follow	VBG
cord-015684-q10sx1dm	244	15	:	:	:
cord-015684-q10sx1dm	244	16	CYP3A4/5/7	CYP3A4/5/7	NNP
cord-015684-q10sx1dm	244	17	,	,	,
cord-015684-q10sx1dm	244	18	CYP2E1	CYP2E1	NNP
cord-015684-q10sx1dm	244	19	,	,	,
cord-015684-q10sx1dm	244	20	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	244	21	,	,	,
cord-015684-q10sx1dm	244	22	CYP2C19	CYP2C19	NNP
cord-015684-q10sx1dm	244	23	,	,	,
cord-015684-q10sx1dm	244	24	CYP2C9	CYP2C9	NNP
cord-015684-q10sx1dm	244	25	,	,	,
cord-015684-q10sx1dm	244	26	CYP2C8	CYP2C8	NNP
cord-015684-q10sx1dm	244	27	,	,	,
cord-015684-q10sx1dm	244	28	CYP2B6	CYP2B6	NNP
cord-015684-q10sx1dm	244	29	,	,	,
cord-015684-q10sx1dm	244	30	CYP2A6	CYP2A6	NNP
cord-015684-q10sx1dm	244	31	,	,	,
cord-015684-q10sx1dm	244	32	CYP1B1	CYP1B1	NNP
cord-015684-q10sx1dm	244	33	,	,	,
cord-015684-q10sx1dm	244	34	CYP1A1/2	CYP1A1/2	NNP
cord-015684-q10sx1dm	244	35	,	,	,
cord-015684-q10sx1dm	244	36	epoxide	epoxide	NN
cord-015684-q10sx1dm	244	37	hydrolase	hydrolase	NN
cord-015684-q10sx1dm	244	38	,	,	,
cord-015684-q10sx1dm	244	39	esterases	esterases	NNP
cord-015684-q10sx1dm	244	40	,	,	,
cord-015684-q10sx1dm	244	41	NQO1	NQO1	NNP
cord-015684-q10sx1dm	244	42	(	(	-LRB-
cord-015684-q10sx1dm	244	43	NADPH	NADPH	NNP
cord-015684-q10sx1dm	244	44	-	-	HYPH
cord-015684-q10sx1dm	244	45	quinone	quinone	NN
cord-015684-q10sx1dm	244	46	oxidoreductase	oxidoreductase	NN
cord-015684-q10sx1dm	244	47	)	)	-RRB-
cord-015684-q10sx1dm	244	48	,	,	,
cord-015684-q10sx1dm	244	49	DPD	DPD	NNP
cord-015684-q10sx1dm	244	50	(	(	-LRB-
cord-015684-q10sx1dm	244	51	dihydropyrimidine	dihydropyrimidine	JJ
cord-015684-q10sx1dm	244	52	dehydrogenase	dehydrogenase	NN
cord-015684-q10sx1dm	244	53	)	)	-RRB-
cord-015684-q10sx1dm	244	54	,	,	,
cord-015684-q10sx1dm	244	55	ADH	ADH	NNP
cord-015684-q10sx1dm	244	56	(	(	-LRB-
cord-015684-q10sx1dm	244	57	alcohol	alcohol	NN
cord-015684-q10sx1dm	244	58	dehydrogenase	dehydrogenase	NN
cord-015684-q10sx1dm	244	59	)	)	-RRB-
cord-015684-q10sx1dm	244	60	,	,	,
cord-015684-q10sx1dm	244	61	and	and	CC
cord-015684-q10sx1dm	244	62	ALDH	ALDH	NNP
cord-015684-q10sx1dm	244	63	(	(	-LRB-
cord-015684-q10sx1dm	244	64	aldehyde	aldehyde	JJ
cord-015684-q10sx1dm	244	65	dehydrogenase	dehydrogenase	NN
cord-015684-q10sx1dm	244	66	)	)	-RRB-
cord-015684-q10sx1dm	244	67	.	.	.
cord-015684-q10sx1dm	245	1	Major	major	JJ
cord-015684-q10sx1dm	245	2	enzymes	enzyme	NNS
cord-015684-q10sx1dm	245	3	involved	involve	VBN
cord-015684-q10sx1dm	245	4	in	in	IN
cord-015684-q10sx1dm	245	5	phase	phase	NN
cord-015684-q10sx1dm	245	6	II	ii	CD
cord-015684-q10sx1dm	245	7	reactions	reaction	NNS
cord-015684-q10sx1dm	245	8	include	include	VBP
cord-015684-q10sx1dm	245	9	the	the	DT
cord-015684-q10sx1dm	245	10	following	follow	VBG
cord-015684-q10sx1dm	245	11	:	:	:
cord-015684-q10sx1dm	245	12	UGTs	ugt	NNS
cord-015684-q10sx1dm	245	13	(	(	-LRB-
cord-015684-q10sx1dm	245	14	uridine	uridine	NNP
cord-015684-q10sx1dm	245	15	5′-triphosphate	5′-triphosphate	CD
cord-015684-q10sx1dm	245	16	glucuronosyl	glucuronosyl	NN
cord-015684-q10sx1dm	245	17	transferases	transferase	NNS
cord-015684-q10sx1dm	245	18	)	)	-RRB-
cord-015684-q10sx1dm	245	19	,	,	,
cord-015684-q10sx1dm	245	20	TPMT	TPMT	NNP
cord-015684-q10sx1dm	245	21	(	(	-LRB-
cord-015684-q10sx1dm	245	22	thiopurine	thiopurine	NNP
cord-015684-q10sx1dm	245	23	methyltransferase	methyltransferase	NNP
cord-015684-q10sx1dm	245	24	)	)	-RRB-
cord-015684-q10sx1dm	245	25	,	,	,
cord-015684-q10sx1dm	245	26	COMT	COMT	NNP
cord-015684-q10sx1dm	245	27	(	(	-LRB-
cord-015684-q10sx1dm	245	28	catechol	catechol	NN
cord-015684-q10sx1dm	245	29	-	-	HYPH
cord-015684-q10sx1dm	245	30	O	o	NN
cord-015684-q10sx1dm	245	31	-	-	HYPH
cord-015684-q10sx1dm	245	32	methyltransferase	methyltransferase	NN
cord-015684-q10sx1dm	245	33	)	)	-RRB-
cord-015684-q10sx1dm	245	34	,	,	,
cord-015684-q10sx1dm	245	35	HMT	HMT	NNP
cord-015684-q10sx1dm	245	36	(	(	-LRB-
cord-015684-q10sx1dm	245	37	histamine	histamine	NN
cord-015684-q10sx1dm	245	38	methyl	methyl	NN
cord-015684-q10sx1dm	245	39	-	-	HYPH
cord-015684-q10sx1dm	245	40	transferase	transferase	NN
cord-015684-q10sx1dm	245	41	)	)	-RRB-
cord-015684-q10sx1dm	245	42	,	,	,
cord-015684-q10sx1dm	245	43	STs	STs	NNPS
cord-015684-q10sx1dm	245	44	(	(	-LRB-
cord-015684-q10sx1dm	245	45	sulfotransferases	sulfotransferases	NNP
cord-015684-q10sx1dm	245	46	)	)	-RRB-
cord-015684-q10sx1dm	245	47	,	,	,
cord-015684-q10sx1dm	245	48	GST	GST	NNP
cord-015684-q10sx1dm	245	49	-	-	HYPH
cord-015684-q10sx1dm	245	50	A	A	NNP
cord-015684-q10sx1dm	245	51	(	(	-LRB-
cord-015684-q10sx1dm	245	52	glutathion	glutathion	NN
cord-015684-q10sx1dm	245	53	S	s	NN
cord-015684-q10sx1dm	245	54	-	-	HYPH
cord-015684-q10sx1dm	245	55	transferase	transferase	NNP
cord-015684-q10sx1dm	245	56	A	A	NNP
cord-015684-q10sx1dm	245	57	)	)	-RRB-
cord-015684-q10sx1dm	245	58	,	,	,
cord-015684-q10sx1dm	245	59	GST	GST	NNP
cord-015684-q10sx1dm	245	60	-	-	HYPH
cord-015684-q10sx1dm	245	61	P	P	NNP
cord-015684-q10sx1dm	245	62	,	,	,
cord-015684-q10sx1dm	245	63	GST	GST	NNP
cord-015684-q10sx1dm	245	64	-	-	HYPH
cord-015684-q10sx1dm	245	65	T	T	NNP
cord-015684-q10sx1dm	245	66	,	,	,
cord-015684-q10sx1dm	245	67	GST	GST	NNP
cord-015684-q10sx1dm	245	68	-	-	HYPH
cord-015684-q10sx1dm	245	69	M	M	NNP
cord-015684-q10sx1dm	245	70	,	,	,
cord-015684-q10sx1dm	245	71	NAT2	NAT2	NNP
cord-015684-q10sx1dm	245	72	(	(	-LRB-
cord-015684-q10sx1dm	245	73	N	n	CD
cord-015684-q10sx1dm	245	74	-	-	HYPH
cord-015684-q10sx1dm	245	75	acetyl	acetyl	NN
cord-015684-q10sx1dm	245	76	transferase	transferase	NN
cord-015684-q10sx1dm	245	77	)	)	-RRB-
cord-015684-q10sx1dm	245	78	,	,	,
cord-015684-q10sx1dm	245	79	NAT1	NAT1	NNP
cord-015684-q10sx1dm	245	80	,	,	,
cord-015684-q10sx1dm	245	81	and	and	CC
cord-015684-q10sx1dm	245	82	others	other	NNS
cord-015684-q10sx1dm	245	83	.	.	.
cord-015684-q10sx1dm	246	1	86	86	CD
cord-015684-q10sx1dm	246	2	Polymorphisms	polymorphism	NNS
cord-015684-q10sx1dm	246	3	in	in	IN
cord-015684-q10sx1dm	246	4	genes	gene	NNS
cord-015684-q10sx1dm	246	5	associated	associate	VBN
cord-015684-q10sx1dm	246	6	with	with	IN
cord-015684-q10sx1dm	246	7	phase	phase	NN
cord-015684-q10sx1dm	246	8	II	ii	CD
cord-015684-q10sx1dm	246	9	metabolism	metabolism	NN
cord-015684-q10sx1dm	246	10	enzymes	enzyme	NNS
cord-015684-q10sx1dm	246	11	,	,	,
cord-015684-q10sx1dm	246	12	such	such	JJ
cord-015684-q10sx1dm	246	13	as	as	IN
cord-015684-q10sx1dm	246	14	GSTM1	GSTM1	NNP
cord-015684-q10sx1dm	246	15	,	,	,
cord-015684-q10sx1dm	246	16	GSTT1	GSTT1	NNP
cord-015684-q10sx1dm	246	17	,	,	,
cord-015684-q10sx1dm	246	18	NAT2	NAT2	NNP
cord-015684-q10sx1dm	246	19	and	and	CC
cord-015684-q10sx1dm	246	20	TPMT	TPMT	NNP
cord-015684-q10sx1dm	246	21	are	be	VBP
cord-015684-q10sx1dm	246	22	well	well	RB
cord-015684-q10sx1dm	246	23	understood	understand	VBN
cord-015684-q10sx1dm	246	24	,	,	,
cord-015684-q10sx1dm	246	25	and	and	CC
cord-015684-q10sx1dm	246	26	information	information	NN
cord-015684-q10sx1dm	246	27	is	be	VBZ
cord-015684-q10sx1dm	246	28	also	also	RB
cord-015684-q10sx1dm	246	29	emerging	emerge	VBG
cord-015684-q10sx1dm	246	30	on	on	IN
cord-015684-q10sx1dm	246	31	other	other	JJ
cord-015684-q10sx1dm	246	32	GST	gst	NN
cord-015684-q10sx1dm	246	33	polymorphisms	polymorphism	NNS
cord-015684-q10sx1dm	246	34	and	and	CC
cord-015684-q10sx1dm	246	35	on	on	IN
cord-015684-q10sx1dm	246	36	polymorphisms	polymorphism	NNS
cord-015684-q10sx1dm	246	37	in	in	IN
cord-015684-q10sx1dm	246	38	the	the	DT
cord-015684-q10sx1dm	246	39	UDP	udp	NN
cord-015684-q10sx1dm	246	40	-	-	HYPH
cord-015684-q10sx1dm	246	41	glucuronosyltransferases	glucuronosyltransferase	NNS
cord-015684-q10sx1dm	246	42	and	and	CC
cord-015684-q10sx1dm	246	43	sulfotransferases	sulfotransferase	NNS
cord-015684-q10sx1dm	246	44	.	.	.
cord-015684-q10sx1dm	247	1	The	the	DT
cord-015684-q10sx1dm	247	2	typical	typical	JJ
cord-015684-q10sx1dm	247	3	paradigm	paradigm	NN
cord-015684-q10sx1dm	247	4	for	for	IN
cord-015684-q10sx1dm	247	5	the	the	DT
cord-015684-q10sx1dm	247	6	pharmacogenetics	pharmacogenetic	NNS
cord-015684-q10sx1dm	247	7	of	of	IN
cord-015684-q10sx1dm	247	8	phase	phase	NN
cord-015684-q10sx1dm	247	9	I	-PRON-	PRP
cord-015684-q10sx1dm	247	10	drug	drug	NN
cord-015684-q10sx1dm	247	11	metabolism	metabolism	NN
cord-015684-q10sx1dm	247	12	is	be	VBZ
cord-015684-q10sx1dm	247	13	represented	represent	VBN
cord-015684-q10sx1dm	247	14	by	by	IN
cord-015684-q10sx1dm	247	15	the	the	DT
cord-015684-q10sx1dm	247	16	cytochrome	cytochrome	NN
cord-015684-q10sx1dm	247	17	P-450	P-450	VBD
cord-015684-q10sx1dm	247	18	enzymes	enzyme	NNS
cord-015684-q10sx1dm	247	19	,	,	,
cord-015684-q10sx1dm	247	20	a	a	DT
cord-015684-q10sx1dm	247	21	superfamily	superfamily	NN
cord-015684-q10sx1dm	247	22	of	of	IN
cord-015684-q10sx1dm	247	23	microsomal	microsomal	NNP
cord-015684-q10sx1dm	247	24	Nonsteroidal	nonsteroidal	JJ
cord-015684-q10sx1dm	247	25	anti	anti	JJ
cord-015684-q10sx1dm	247	26	-	-	JJ
cord-015684-q10sx1dm	247	27	infl	infl	JJ
cord-015684-q10sx1dm	247	28	ammatory	ammatory	NNP
cord-015684-q10sx1dm	247	29	drug	drug	NNP
cord-015684-q10sx1dm	247	30	drug	drug	NN
cord-015684-q10sx1dm	247	31	-	-	HYPH
cord-015684-q10sx1dm	247	32	metabolizing	metabolize	VBG
cord-015684-q10sx1dm	247	33	enzymes	enzyme	NNS
cord-015684-q10sx1dm	247	34	.	.	.
cord-015684-q10sx1dm	248	1	P450	p450	JJ
cord-015684-q10sx1dm	248	2	enzymes	enzyme	NNS
cord-015684-q10sx1dm	248	3	comprise	comprise	VBP
cord-015684-q10sx1dm	248	4	a	a	DT
cord-015684-q10sx1dm	248	5	superfamily	superfamily	NN
cord-015684-q10sx1dm	248	6	of	of	IN
cord-015684-q10sx1dm	248	7	heme	heme	JJ
cord-015684-q10sx1dm	248	8	-	-	HYPH
cord-015684-q10sx1dm	248	9	thiolate	thiolate	NN
cord-015684-q10sx1dm	248	10	proteins	protein	NNS
cord-015684-q10sx1dm	248	11	widely	widely	RB
cord-015684-q10sx1dm	248	12	distributed	distribute	VBN
cord-015684-q10sx1dm	248	13	in	in	IN
cord-015684-q10sx1dm	248	14	bacteria	bacteria	NNS
cord-015684-q10sx1dm	248	15	,	,	,
cord-015684-q10sx1dm	248	16	fungi	fungus	NNS
cord-015684-q10sx1dm	248	17	,	,	,
cord-015684-q10sx1dm	248	18	plants	plant	NNS
cord-015684-q10sx1dm	248	19	and	and	CC
cord-015684-q10sx1dm	248	20	animals	animal	NNS
cord-015684-q10sx1dm	248	21	.	.	.
cord-015684-q10sx1dm	249	1	The	the	DT
cord-015684-q10sx1dm	249	2	P450	p450	JJ
cord-015684-q10sx1dm	249	3	enzymes	enzyme	NNS
cord-015684-q10sx1dm	249	4	are	be	VBP
cord-015684-q10sx1dm	249	5	encoded	encode	VBN
cord-015684-q10sx1dm	249	6	in	in	IN
cord-015684-q10sx1dm	249	7	genes	gene	NNS
cord-015684-q10sx1dm	249	8	of	of	IN
cord-015684-q10sx1dm	249	9	the	the	DT
cord-015684-q10sx1dm	249	10	CYP	CYP	NNP
cord-015684-q10sx1dm	249	11	superfamily	superfamily	NN
cord-015684-q10sx1dm	249	12	(	(	-LRB-
cord-015684-q10sx1dm	249	13	Table	table	NN
cord-015684-q10sx1dm	249	14	40	40	CD
cord-015684-q10sx1dm	249	15	.6	.6	CD
cord-015684-q10sx1dm	249	16	)	)	-RRB-
cord-015684-q10sx1dm	249	17	and	and	CC
cord-015684-q10sx1dm	249	18	act	act	VB
cord-015684-q10sx1dm	249	19	as	as	IN
cord-015684-q10sx1dm	249	20	terminal	terminal	JJ
cord-015684-q10sx1dm	249	21	oxidases	oxidase	NNS
cord-015684-q10sx1dm	249	22	in	in	IN
cord-015684-q10sx1dm	249	23	multicomponent	multicomponent	NN
cord-015684-q10sx1dm	249	24	electron	electron	NN
cord-015684-q10sx1dm	249	25	transfer	transfer	NN
cord-015684-q10sx1dm	249	26	chains	chain	NNS
cord-015684-q10sx1dm	249	27	which	which	WDT
cord-015684-q10sx1dm	249	28	are	be	VBP
cord-015684-q10sx1dm	249	29	called	call	VBN
cord-015684-q10sx1dm	249	30	P450containing	p450containe	VBG
cord-015684-q10sx1dm	249	31	monooxigenase	monooxigenase	NNP
cord-015684-q10sx1dm	249	32	systems	system	NNS
cord-015684-q10sx1dm	249	33	.	.	.
cord-015684-q10sx1dm	250	1	Some	some	DT
cord-015684-q10sx1dm	250	2	of	of	IN
cord-015684-q10sx1dm	250	3	the	the	DT
cord-015684-q10sx1dm	250	4	enzymatic	enzymatic	JJ
cord-015684-q10sx1dm	250	5	products	product	NNS
cord-015684-q10sx1dm	250	6	of	of	IN
cord-015684-q10sx1dm	250	7	the	the	DT
cord-015684-q10sx1dm	250	8	CYP	CYP	NNP
cord-015684-q10sx1dm	250	9	gene	gene	NN
cord-015684-q10sx1dm	250	10	superfamily	superfamily	NN
cord-015684-q10sx1dm	250	11	can	can	MD
cord-015684-q10sx1dm	250	12	share	share	VB
cord-015684-q10sx1dm	250	13	substrates	substrate	NNS
cord-015684-q10sx1dm	250	14	,	,	,
cord-015684-q10sx1dm	250	15	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	250	16	and	and	CC
cord-015684-q10sx1dm	250	17	inducers	inducer	NNS
cord-015684-q10sx1dm	250	18	whereas	whereas	IN
cord-015684-q10sx1dm	250	19	others	other	NNS
cord-015684-q10sx1dm	250	20	are	be	VBP
cord-015684-q10sx1dm	250	21	quite	quite	RB
cord-015684-q10sx1dm	250	22	specifi	specifi	JJ
cord-015684-q10sx1dm	250	23	c	c	NN
cord-015684-q10sx1dm	250	24	for	for	IN
cord-015684-q10sx1dm	250	25	their	-PRON-	PRP$
cord-015684-q10sx1dm	250	26	substrates	substrate	NNS
cord-015684-q10sx1dm	250	27	and	and	CC
cord-015684-q10sx1dm	250	28	interacting	interact	VBG
cord-015684-q10sx1dm	250	29	drugs	drug	NNS
cord-015684-q10sx1dm	250	30	.	.	.
cord-015684-q10sx1dm	251	1	[	[	-LRB-
cord-015684-q10sx1dm	251	2	18	18	CD
cord-015684-q10sx1dm	251	3	]	]	-RRB-
cord-015684-q10sx1dm	251	4	[	[	-LRB-
cord-015684-q10sx1dm	251	5	19	19	CD
cord-015684-q10sx1dm	251	6	]	]	-RRB-
cord-015684-q10sx1dm	251	7	[	[	-LRB-
cord-015684-q10sx1dm	251	8	20	20	CD
cord-015684-q10sx1dm	251	9	]	]	-RRB-
cord-015684-q10sx1dm	251	10	[	[	-LRB-
cord-015684-q10sx1dm	251	11	71	71	CD
cord-015684-q10sx1dm	251	12	]	]	-RRB-
cord-015684-q10sx1dm	251	13	[	[	-LRB-
cord-015684-q10sx1dm	251	14	72	72	CD
cord-015684-q10sx1dm	251	15	]	]	-RRB-
cord-015684-q10sx1dm	251	16	[	[	-LRB-
cord-015684-q10sx1dm	251	17	73	73	CD
cord-015684-q10sx1dm	251	18	]	]	-RRB-
cord-015684-q10sx1dm	251	19	[	[	-LRB-
cord-015684-q10sx1dm	251	20	78	78	CD
cord-015684-q10sx1dm	251	21	]	]	-RRB-
cord-015684-q10sx1dm	251	22	[	[	-LRB-
cord-015684-q10sx1dm	251	23	79	79	CD
cord-015684-q10sx1dm	251	24	]	]	-RRB-
cord-015684-q10sx1dm	252	1	[	[	-LRB-
cord-015684-q10sx1dm	252	2	80	80	CD
cord-015684-q10sx1dm	252	3	]	]	-RRB-
cord-015684-q10sx1dm	253	1	There	there	EX
cord-015684-q10sx1dm	253	2	are	be	VBP
cord-015684-q10sx1dm	253	3	more	more	JJR
cord-015684-q10sx1dm	253	4	than	than	IN
cord-015684-q10sx1dm	253	5	200	200	CD
cord-015684-q10sx1dm	253	6	P450	p450	JJ
cord-015684-q10sx1dm	253	7	genes	gene	NNS
cord-015684-q10sx1dm	253	8	identifi	identifi	NNP
cord-015684-q10sx1dm	253	9	ed	ed	NN
cord-015684-q10sx1dm	253	10	in	in	IN
cord-015684-q10sx1dm	253	11	different	different	JJ
cord-015684-q10sx1dm	253	12	species	specie	NNS
cord-015684-q10sx1dm	253	13	.	.	.
cord-015684-q10sx1dm	254	1	Saito	Saito	NNP
cord-015684-q10sx1dm	254	2	et	et	NNP
cord-015684-q10sx1dm	254	3	al	al	NNP
cord-015684-q10sx1dm	254	4	87	87	CD
cord-015684-q10sx1dm	254	5	provided	provide	VBD
cord-015684-q10sx1dm	254	6	a	a	DT
cord-015684-q10sx1dm	254	7	catalogue	catalogue	NN
cord-015684-q10sx1dm	254	8	of	of	IN
cord-015684-q10sx1dm	254	9	680	680	CD
cord-015684-q10sx1dm	254	10	variants	variant	NNS
cord-015684-q10sx1dm	254	11	among	among	IN
cord-015684-q10sx1dm	254	12	eight	eight	CD
cord-015684-q10sx1dm	254	13	CYP450	cyp450	JJ
cord-015684-q10sx1dm	254	14	genes	gene	NNS
cord-015684-q10sx1dm	254	15	,	,	,
cord-015684-q10sx1dm	254	16	nine	nine	CD
cord-015684-q10sx1dm	254	17	esterase	esterase	NN
cord-015684-q10sx1dm	254	18	genes	gene	NNS
cord-015684-q10sx1dm	254	19	,	,	,
cord-015684-q10sx1dm	254	20	and	and	CC
cord-015684-q10sx1dm	254	21	two	two	CD
cord-015684-q10sx1dm	254	22	other	other	JJ
cord-015684-q10sx1dm	254	23	genes	gene	NNS
cord-015684-q10sx1dm	254	24	in	in	IN
cord-015684-q10sx1dm	254	25	the	the	DT
cord-015684-q10sx1dm	254	26	Japanese	japanese	JJ
cord-015684-q10sx1dm	254	27	population	population	NN
cord-015684-q10sx1dm	254	28	.	.	.
cord-015684-q10sx1dm	255	1	The	the	DT
cord-015684-q10sx1dm	255	2	microsomal	microsomal	NN
cord-015684-q10sx1dm	255	3	,	,	,
cord-015684-q10sx1dm	255	4	membrane	membrane	NN
cord-015684-q10sx1dm	255	5	-	-	HYPH
cord-015684-q10sx1dm	255	6	associated	associate	VBN
cord-015684-q10sx1dm	255	7	,	,	,
cord-015684-q10sx1dm	256	1	P450	p450	JJ
cord-015684-q10sx1dm	256	2	isoforms	isoform	NNS
cord-015684-q10sx1dm	256	3	CYP3A4	CYP3A4	NNP
cord-015684-q10sx1dm	256	4	,	,	,
cord-015684-q10sx1dm	256	5	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	256	6	,	,	,
cord-015684-q10sx1dm	256	7	CYP2C9	CYP2C9	NNP
cord-015684-q10sx1dm	256	8	,	,	,
cord-015684-q10sx1dm	256	9	CYP2C19	CYP2C19	NNP
cord-015684-q10sx1dm	256	10	,	,	,
cord-015684-q10sx1dm	256	11	CYP2E1	CYP2E1	NNP
cord-015684-q10sx1dm	256	12	,	,	,
cord-015684-q10sx1dm	256	13	and	and	CC
cord-015684-q10sx1dm	256	14	CYP1A2	CYP1A2	NNP
cord-015684-q10sx1dm	256	15	are	be	VBP
cord-015684-q10sx1dm	256	16	responsible	responsible	JJ
cord-015684-q10sx1dm	256	17	for	for	IN
cord-015684-q10sx1dm	256	18	the	the	DT
cord-015684-q10sx1dm	256	19	oxidative	oxidative	JJ
cord-015684-q10sx1dm	256	20	metabolism	metabolism	NN
cord-015684-q10sx1dm	256	21	of	of	IN
cord-015684-q10sx1dm	256	22	more	more	JJR
cord-015684-q10sx1dm	256	23	than	than	IN
cord-015684-q10sx1dm	256	24	90	90	CD
cord-015684-q10sx1dm	256	25	%	%	NN
cord-015684-q10sx1dm	256	26	of	of	IN
cord-015684-q10sx1dm	256	27	marketed	market	VBN
cord-015684-q10sx1dm	256	28	drugs	drug	NNS
cord-015684-q10sx1dm	256	29	.	.	.
cord-015684-q10sx1dm	257	1	About	about	RB
cord-015684-q10sx1dm	257	2	60	60	CD
cord-015684-q10sx1dm	257	3	-	-	SYM
cord-015684-q10sx1dm	257	4	80	80	CD
cord-015684-q10sx1dm	257	5	%	%	NN
cord-015684-q10sx1dm	257	6	of	of	IN
cord-015684-q10sx1dm	257	7	the	the	DT
cord-015684-q10sx1dm	257	8	psychotropic	psychotropic	JJ
cord-015684-q10sx1dm	257	9	agents	agent	NNS
cord-015684-q10sx1dm	257	10	currently	currently	RB
cord-015684-q10sx1dm	257	11	used	use	VBN
cord-015684-q10sx1dm	257	12	for	for	IN
cord-015684-q10sx1dm	257	13	the	the	DT
cord-015684-q10sx1dm	257	14	treatment	treatment	NN
cord-015684-q10sx1dm	257	15	of	of	IN
cord-015684-q10sx1dm	257	16	neuropsychiatric	neuropsychiatric	JJ
cord-015684-q10sx1dm	257	17	disorders	disorder	NNS
cord-015684-q10sx1dm	257	18	are	be	VBP
cord-015684-q10sx1dm	257	19	metabolized	metabolize	VBN
cord-015684-q10sx1dm	257	20	via	via	IN
cord-015684-q10sx1dm	257	21	enzymes	enzyme	NNS
cord-015684-q10sx1dm	257	22	of	of	IN
cord-015684-q10sx1dm	257	23	the	the	DT
cord-015684-q10sx1dm	257	24	CYP	CYP	NNP
cord-015684-q10sx1dm	257	25	family	family	NN
cord-015684-q10sx1dm	257	26	,	,	,
cord-015684-q10sx1dm	257	27	especially	especially	RB
cord-015684-q10sx1dm	257	28	CYP1A2	CYP1A2	NNP
cord-015684-q10sx1dm	257	29	,	,	,
cord-015684-q10sx1dm	257	30	CYP2B6	CYP2B6	NNP
cord-015684-q10sx1dm	257	31	,	,	,
cord-015684-q10sx1dm	257	32	CYP2C8/9	CYP2C8/9	NNP
cord-015684-q10sx1dm	257	33	,	,	,
cord-015684-q10sx1dm	257	34	CYP2C19	CYP2C19	NNP
cord-015684-q10sx1dm	257	35	,	,	,
cord-015684-q10sx1dm	257	36	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	257	37	and	and	CC
cord-015684-q10sx1dm	257	38	CYP3A4	CYP3A4	NNP
cord-015684-q10sx1dm	257	39	(	(	-LRB-
cord-015684-q10sx1dm	257	40	Table	table	NN
cord-015684-q10sx1dm	257	41	40	40	CD
cord-015684-q10sx1dm	257	42	.5	.5	CD
cord-015684-q10sx1dm	257	43	)	)	-RRB-
cord-015684-q10sx1dm	257	44	.	.	.
cord-015684-q10sx1dm	258	1	CYP3A4	CYP3A4	NNP
cord-015684-q10sx1dm	258	2	metabolizes	metabolize	VBZ
cord-015684-q10sx1dm	258	3	more	more	JJR
cord-015684-q10sx1dm	258	4	drug	drug	NN
cord-015684-q10sx1dm	258	5	molecules	molecule	NNS
cord-015684-q10sx1dm	258	6	than	than	IN
cord-015684-q10sx1dm	258	7	all	all	DT
cord-015684-q10sx1dm	258	8	other	other	JJ
cord-015684-q10sx1dm	258	9	isoforms	isoform	NNS
cord-015684-q10sx1dm	258	10	together	together	RB
cord-015684-q10sx1dm	258	11	.	.	.
cord-015684-q10sx1dm	259	1	Most	Most	JJS
cord-015684-q10sx1dm	259	2	of	of	IN
cord-015684-q10sx1dm	259	3	these	these	DT
cord-015684-q10sx1dm	259	4	polymorphisms	polymorphism	NNS
cord-015684-q10sx1dm	259	5	exhibit	exhibit	VBP
cord-015684-q10sx1dm	259	6	geographic	geographic	JJ
cord-015684-q10sx1dm	259	7	and	and	CC
cord-015684-q10sx1dm	259	8	ethnic	ethnic	JJ
cord-015684-q10sx1dm	259	9	differences	difference	NNS
cord-015684-q10sx1dm	259	10	.	.	.
cord-015684-q10sx1dm	260	1	[	[	-LRB-
cord-015684-q10sx1dm	260	2	88	88	CD
cord-015684-q10sx1dm	260	3	]	]	-RRB-
cord-015684-q10sx1dm	260	4	[	[	-LRB-
cord-015684-q10sx1dm	260	5	89	89	CD
cord-015684-q10sx1dm	260	6	]	]	-RRB-
cord-015684-q10sx1dm	261	1	[	[	-LRB-
cord-015684-q10sx1dm	261	2	90	90	CD
cord-015684-q10sx1dm	261	3	]	]	-RRB-
cord-015684-q10sx1dm	261	4	[	[	-LRB-
cord-015684-q10sx1dm	261	5	91	91	CD
cord-015684-q10sx1dm	261	6	]	]	-RRB-
cord-015684-q10sx1dm	261	7	[	[	-LRB-
cord-015684-q10sx1dm	261	8	92	92	CD
cord-015684-q10sx1dm	261	9	]	]	-RRB-
cord-015684-q10sx1dm	262	1	[	[	-LRB-
cord-015684-q10sx1dm	262	2	93	93	CD
cord-015684-q10sx1dm	262	3	]	]	-RRB-
cord-015684-q10sx1dm	263	1	[	[	-LRB-
cord-015684-q10sx1dm	263	2	94	94	CD
cord-015684-q10sx1dm	263	3	]	]	-RRB-
cord-015684-q10sx1dm	264	1	These	these	DT
cord-015684-q10sx1dm	264	2	differences	difference	NNS
cord-015684-q10sx1dm	264	3	infl	infl	XX
cord-015684-q10sx1dm	264	4	uence	uence	NN
cord-015684-q10sx1dm	264	5	drug	drug	NN
cord-015684-q10sx1dm	264	6	metabolism	metabolism	NN
cord-015684-q10sx1dm	264	7	in	in	IN
cord-015684-q10sx1dm	264	8	different	different	JJ
cord-015684-q10sx1dm	264	9	ethnic	ethnic	JJ
cord-015684-q10sx1dm	264	10	groups	group	NNS
cord-015684-q10sx1dm	264	11	in	in	IN
cord-015684-q10sx1dm	264	12	which	which	WDT
cord-015684-q10sx1dm	264	13	drug	drug	NN
cord-015684-q10sx1dm	264	14	dosage	dosage	NN
cord-015684-q10sx1dm	264	15	should	should	MD
cord-015684-q10sx1dm	264	16	be	be	VB
cord-015684-q10sx1dm	264	17	adjusted	adjust	VBN
cord-015684-q10sx1dm	264	18	according	accord	VBG
cord-015684-q10sx1dm	264	19	to	to	IN
cord-015684-q10sx1dm	264	20	their	-PRON-	PRP$
cord-015684-q10sx1dm	264	21	enzymatic	enzymatic	JJ
cord-015684-q10sx1dm	264	22	capacity	capacity	NN
cord-015684-q10sx1dm	264	23	,	,	,
cord-015684-q10sx1dm	264	24	differentiating	differentiate	VBG
cord-015684-q10sx1dm	264	25	normal	normal	JJ
cord-015684-q10sx1dm	264	26	or	or	CC
cord-015684-q10sx1dm	264	27	extensive	extensive	JJ
cord-015684-q10sx1dm	264	28	metabolizers	metabolizer	NNS
cord-015684-q10sx1dm	264	29	(	(	-LRB-
cord-015684-q10sx1dm	264	30	EMs	EMs	NNP
cord-015684-q10sx1dm	264	31	)	)	-RRB-
cord-015684-q10sx1dm	264	32	,	,	,
cord-015684-q10sx1dm	264	33	poor	poor	JJ
cord-015684-q10sx1dm	264	34	metabolizers	metabolizer	NNS
cord-015684-q10sx1dm	264	35	(	(	-LRB-
cord-015684-q10sx1dm	264	36	PMs	PMs	NNP
cord-015684-q10sx1dm	264	37	)	)	-RRB-
cord-015684-q10sx1dm	264	38	and	and	CC
cord-015684-q10sx1dm	264	39	ultrarapid	ultrarapid	NNP
cord-015684-q10sx1dm	264	40	metabolizers	metabolizer	NNS
cord-015684-q10sx1dm	264	41	(	(	-LRB-
cord-015684-q10sx1dm	264	42	UMs	UMs	NNPS
cord-015684-q10sx1dm	264	43	)	)	-RRB-
cord-015684-q10sx1dm	264	44	.	.	.
cord-015684-q10sx1dm	265	1	Most	Most	JJS
cord-015684-q10sx1dm	265	2	drugs	drug	NNS
cord-015684-q10sx1dm	265	3	act	act	VBP
cord-015684-q10sx1dm	265	4	as	as	IN
cord-015684-q10sx1dm	265	5	substrates	substrate	NNS
cord-015684-q10sx1dm	265	6	,	,	,
cord-015684-q10sx1dm	265	7	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	265	8	or	or	CC
cord-015684-q10sx1dm	265	9	inducers	inducer	NNS
cord-015684-q10sx1dm	265	10	of	of	IN
cord-015684-q10sx1dm	265	11	CYP	CYP	NNP
cord-015684-q10sx1dm	265	12	enzymes	enzyme	NNS
cord-015684-q10sx1dm	265	13	.	.	.
cord-015684-q10sx1dm	266	1	Enzyme	enzyme	NN
cord-015684-q10sx1dm	266	2	induction	induction	NN
cord-015684-q10sx1dm	266	3	enables	enable	VBZ
cord-015684-q10sx1dm	266	4	some	some	DT
cord-015684-q10sx1dm	266	5	xenobiotics	xenobiotic	NNS
cord-015684-q10sx1dm	266	6	to	to	TO
cord-015684-q10sx1dm	266	7	accelerate	accelerate	VB
cord-015684-q10sx1dm	266	8	their	-PRON-	PRP$
cord-015684-q10sx1dm	266	9	own	own	JJ
cord-015684-q10sx1dm	266	10	biotransformation	biotransformation	NN
cord-015684-q10sx1dm	266	11	(	(	-LRB-
cord-015684-q10sx1dm	266	12	auto	auto	NN
cord-015684-q10sx1dm	266	13	-	-	HYPH
cord-015684-q10sx1dm	266	14	induction	induction	NN
cord-015684-q10sx1dm	266	15	)	)	-RRB-
cord-015684-q10sx1dm	266	16	or	or	CC
cord-015684-q10sx1dm	266	17	the	the	DT
cord-015684-q10sx1dm	266	18	biotransformation	biotransformation	NN
cord-015684-q10sx1dm	266	19	and	and	CC
cord-015684-q10sx1dm	266	20	elimination	elimination	NN
cord-015684-q10sx1dm	266	21	of	of	IN
cord-015684-q10sx1dm	266	22	other	other	JJ
cord-015684-q10sx1dm	266	23	drugs	drug	NNS
cord-015684-q10sx1dm	266	24	.	.	.
cord-015684-q10sx1dm	267	1	A	a	DT
cord-015684-q10sx1dm	267	2	number	number	NN
cord-015684-q10sx1dm	267	3	of	of	IN
cord-015684-q10sx1dm	267	4	P450	p450	JJ
cord-015684-q10sx1dm	267	5	enzymes	enzyme	NNS
cord-015684-q10sx1dm	267	6	in	in	IN
cord-015684-q10sx1dm	267	7	human	human	JJ
cord-015684-q10sx1dm	267	8	liver	liver	NN
cord-015684-q10sx1dm	267	9	are	be	VBP
cord-015684-q10sx1dm	267	10	inducible	inducible	JJ
cord-015684-q10sx1dm	267	11	.	.	.
cord-015684-q10sx1dm	268	1	Induction	induction	NN
cord-015684-q10sx1dm	268	2	of	of	IN
cord-015684-q10sx1dm	268	3	the	the	DT
cord-015684-q10sx1dm	268	4	majority	majority	NN
cord-015684-q10sx1dm	268	5	of	of	IN
cord-015684-q10sx1dm	268	6	P450	p450	JJ
cord-015684-q10sx1dm	268	7	enzymes	enzyme	NNS
cord-015684-q10sx1dm	268	8	occurs	occur	VBZ
cord-015684-q10sx1dm	268	9	by	by	IN
cord-015684-q10sx1dm	268	10	increase	increase	NN
cord-015684-q10sx1dm	268	11	in	in	IN
cord-015684-q10sx1dm	268	12	the	the	DT
cord-015684-q10sx1dm	268	13	rate	rate	NN
cord-015684-q10sx1dm	268	14	of	of	IN
cord-015684-q10sx1dm	268	15	gene	gene	NN
cord-015684-q10sx1dm	268	16	transcription	transcription	NN
cord-015684-q10sx1dm	268	17	and	and	CC
cord-015684-q10sx1dm	268	18	involves	involve	VBZ
cord-015684-q10sx1dm	268	19	ligand	ligand	NN
cord-015684-q10sx1dm	268	20	-	-	HYPH
cord-015684-q10sx1dm	268	21	activated	activate	VBN
cord-015684-q10sx1dm	268	22	transcription	transcription	NN
cord-015684-q10sx1dm	268	23	factors	factor	NNS
cord-015684-q10sx1dm	268	24	,	,	,
cord-015684-q10sx1dm	268	25	aryl	aryl	NN
cord-015684-q10sx1dm	268	26	hydrocarbon	hydrocarbon	NN
cord-015684-q10sx1dm	268	27	receptor	receptor	NN
cord-015684-q10sx1dm	268	28	,	,	,
cord-015684-q10sx1dm	268	29	constitutive	constitutive	JJ
cord-015684-q10sx1dm	268	30	androstane	androstane	NN
cord-015684-q10sx1dm	268	31	receptor	receptor	NN
cord-015684-q10sx1dm	268	32	(	(	-LRB-
cord-015684-q10sx1dm	268	33	CAR	car	NN
cord-015684-q10sx1dm	268	34	)	)	-RRB-
cord-015684-q10sx1dm	268	35	,	,	,
cord-015684-q10sx1dm	268	36	and	and	CC
cord-015684-q10sx1dm	268	37	pregnane	pregnane	NNP
cord-015684-q10sx1dm	268	38	X	X	NNP
cord-015684-q10sx1dm	268	39	receptor	receptor	NN
cord-015684-q10sx1dm	268	40	(	(	-LRB-
cord-015684-q10sx1dm	268	41	PXR	PXR	NNP
cord-015684-q10sx1dm	268	42	)	)	-RRB-
cord-015684-q10sx1dm	268	43	.	.	.
cord-015684-q10sx1dm	269	1	93	93	CD
cord-015684-q10sx1dm	269	2	,	,	,
cord-015684-q10sx1dm	269	3	95	95	CD
cord-015684-q10sx1dm	270	1	In	in	IN
cord-015684-q10sx1dm	270	2	general	general	JJ
cord-015684-q10sx1dm	270	3	,	,	,
cord-015684-q10sx1dm	270	4	binding	bind	VBG
cord-015684-q10sx1dm	270	5	of	of	IN
cord-015684-q10sx1dm	270	6	the	the	DT
cord-015684-q10sx1dm	270	7	appropriate	appropriate	JJ
cord-015684-q10sx1dm	270	8	ligand	ligand	NN
cord-015684-q10sx1dm	270	9	to	to	IN
cord-015684-q10sx1dm	270	10	the	the	DT
cord-015684-q10sx1dm	270	11	receptor	receptor	NN
cord-015684-q10sx1dm	270	12	initiates	initiate	VBZ
cord-015684-q10sx1dm	270	13	the	the	DT
cord-015684-q10sx1dm	270	14	induction	induction	NN
cord-015684-q10sx1dm	270	15	process	process	NN
cord-015684-q10sx1dm	270	16	that	that	WDT
cord-015684-q10sx1dm	270	17	cascades	cascade	VBZ
cord-015684-q10sx1dm	270	18	through	through	IN
cord-015684-q10sx1dm	270	19	a	a	DT
cord-015684-q10sx1dm	270	20	dimerization	dimerization	NN
cord-015684-q10sx1dm	270	21	of	of	IN
cord-015684-q10sx1dm	270	22	the	the	DT
cord-015684-q10sx1dm	270	23	receptors	receptor	NNS
cord-015684-q10sx1dm	270	24	,	,	,
cord-015684-q10sx1dm	270	25	their	-PRON-	PRP$
cord-015684-q10sx1dm	270	26	translocation	translocation	NN
cord-015684-q10sx1dm	270	27	to	to	IN
cord-015684-q10sx1dm	270	28	the	the	DT
cord-015684-q10sx1dm	270	29	nucleus	nucleus	NN
cord-015684-q10sx1dm	270	30	and	and	CC
cord-015684-q10sx1dm	270	31	binding	bind	VBG
cord-015684-q10sx1dm	270	32	to	to	IN
cord-015684-q10sx1dm	270	33	specifi	specifi	NN
cord-015684-q10sx1dm	270	34	c	c	NN
cord-015684-q10sx1dm	270	35	regions	region	NNS
cord-015684-q10sx1dm	270	36	in	in	IN
cord-015684-q10sx1dm	270	37	the	the	DT
cord-015684-q10sx1dm	270	38	promoters	promoter	NNS
cord-015684-q10sx1dm	270	39	of	of	IN
cord-015684-q10sx1dm	270	40	CYPs	cyp	NNS
cord-015684-q10sx1dm	270	41	.	.	.
cord-015684-q10sx1dm	271	1	95	95	CD
cord-015684-q10sx1dm	271	2	CYPs	cyp	NNS
cord-015684-q10sx1dm	271	3	are	be	VBP
cord-015684-q10sx1dm	271	4	also	also	RB
cord-015684-q10sx1dm	271	5	expressed	express	VBN
cord-015684-q10sx1dm	271	6	in	in	IN
cord-015684-q10sx1dm	271	7	the	the	DT
cord-015684-q10sx1dm	271	8	CNS	CNS	NNP
cord-015684-q10sx1dm	271	9	,	,	,
cord-015684-q10sx1dm	271	10	and	and	CC
cord-015684-q10sx1dm	271	11	a	a	DT
cord-015684-q10sx1dm	271	12	complete	complete	JJ
cord-015684-q10sx1dm	271	13	characterization	characterization	NN
cord-015684-q10sx1dm	271	14	of	of	IN
cord-015684-q10sx1dm	271	15	constitutive	constitutive	JJ
cord-015684-q10sx1dm	271	16	and	and	CC
cord-015684-q10sx1dm	271	17	induced	induced	JJ
cord-015684-q10sx1dm	271	18	CYPs	cyps	NN
cord-015684-q10sx1dm	271	19	in	in	IN
cord-015684-q10sx1dm	271	20	brain	brain	NN
cord-015684-q10sx1dm	271	21	is	be	VBZ
cord-015684-q10sx1dm	271	22	essential	essential	JJ
cord-015684-q10sx1dm	271	23	for	for	IN
cord-015684-q10sx1dm	271	24	understanding	understand	VBG
cord-015684-q10sx1dm	271	25	the	the	DT
cord-015684-q10sx1dm	271	26	role	role	NN
cord-015684-q10sx1dm	271	27	of	of	IN
cord-015684-q10sx1dm	271	28	these	these	DT
cord-015684-q10sx1dm	271	29	enzymes	enzyme	NNS
cord-015684-q10sx1dm	271	30	in	in	IN
cord-015684-q10sx1dm	271	31	neurobiological	neurobiological	JJ
cord-015684-q10sx1dm	271	32	functions	function	NNS
cord-015684-q10sx1dm	271	33	and	and	CC
cord-015684-q10sx1dm	271	34	in	in	IN
cord-015684-q10sx1dm	271	35	age	age	NN
cord-015684-q10sx1dm	271	36	-	-	HYPH
cord-015684-q10sx1dm	271	37	related	relate	VBN
cord-015684-q10sx1dm	271	38	and	and	CC
cord-015684-q10sx1dm	271	39	xenobiotic	xenobiotic	JJ
cord-015684-q10sx1dm	271	40	-	-	HYPH
cord-015684-q10sx1dm	271	41	induced	induce	VBN
cord-015684-q10sx1dm	271	42	neurotoxicity	neurotoxicity	NN
cord-015684-q10sx1dm	271	43	.	.	.
cord-015684-q10sx1dm	272	1	96	96	CD
cord-015684-q10sx1dm	273	1	Assuming	assume	VBG
cord-015684-q10sx1dm	273	2	that	that	IN
cord-015684-q10sx1dm	273	3	the	the	DT
cord-015684-q10sx1dm	273	4	human	human	JJ
cord-015684-q10sx1dm	273	5	genome	genome	NN
cord-015684-q10sx1dm	273	6	contains	contain	VBZ
cord-015684-q10sx1dm	273	7	about	about	IN
cord-015684-q10sx1dm	273	8	20,000	20,000	CD
cord-015684-q10sx1dm	273	9	-	-	SYM
cord-015684-q10sx1dm	273	10	30,000	30,000	CD
cord-015684-q10sx1dm	273	11	genes	gene	NNS
cord-015684-q10sx1dm	273	12	,	,	,
cord-015684-q10sx1dm	273	13	at	at	IN
cord-015684-q10sx1dm	273	14	the	the	DT
cord-015684-q10sx1dm	273	15	present	present	JJ
cord-015684-q10sx1dm	273	16	time	time	NN
cord-015684-q10sx1dm	273	17	only	only	RB
cord-015684-q10sx1dm	273	18	0.31	0.31	CD
cord-015684-q10sx1dm	273	19	%	%	NN
cord-015684-q10sx1dm	273	20	of	of	IN
cord-015684-q10sx1dm	273	21	commercial	commercial	JJ
cord-015684-q10sx1dm	273	22	drugs	drug	NNS
cord-015684-q10sx1dm	273	23	have	have	VBP
cord-015684-q10sx1dm	273	24	been	be	VBN
cord-015684-q10sx1dm	273	25	assigned	assign	VBN
cord-015684-q10sx1dm	273	26	to	to	IN
cord-015684-q10sx1dm	273	27	corresponding	corresponding	JJ
cord-015684-q10sx1dm	273	28	genes	gene	NNS
cord-015684-q10sx1dm	273	29	whose	whose	WP$
cord-015684-q10sx1dm	273	30	gene	gene	NN
cord-015684-q10sx1dm	273	31	products	product	NNS
cord-015684-q10sx1dm	273	32	might	may	MD
cord-015684-q10sx1dm	273	33	be	be	VB
cord-015684-q10sx1dm	273	34	involved	involve	VBN
cord-015684-q10sx1dm	273	35	in	in	IN
cord-015684-q10sx1dm	273	36	pharmacokinetic	pharmacokinetic	JJ
cord-015684-q10sx1dm	273	37	and	and	CC
cord-015684-q10sx1dm	273	38	pharmacodynamic	pharmacodynamic	JJ
cord-015684-q10sx1dm	273	39	activities	activity	NNS
cord-015684-q10sx1dm	273	40	of	of	IN
cord-015684-q10sx1dm	273	41	a	a	DT
cord-015684-q10sx1dm	273	42	given	give	VBN
cord-015684-q10sx1dm	273	43	drug	drug	NN
cord-015684-q10sx1dm	273	44	;	;	:
cord-015684-q10sx1dm	273	45	and	and	CC
cord-015684-q10sx1dm	273	46	only	only	RB
cord-015684-q10sx1dm	273	47	4	4	CD
cord-015684-q10sx1dm	273	48	%	%	NN
cord-015684-q10sx1dm	273	49	of	of	IN
cord-015684-q10sx1dm	273	50	the	the	DT
cord-015684-q10sx1dm	273	51	human	human	JJ
cord-015684-q10sx1dm	273	52	genes	gene	NNS
cord-015684-q10sx1dm	273	53	have	have	VBP
cord-015684-q10sx1dm	273	54	been	be	VBN
cord-015684-q10sx1dm	273	55	assigned	assign	VBN
cord-015684-q10sx1dm	273	56	to	to	IN
cord-015684-q10sx1dm	273	57	a	a	DT
cord-015684-q10sx1dm	273	58	particular	particular	JJ
cord-015684-q10sx1dm	273	59	drug	drug	NN
cord-015684-q10sx1dm	273	60	metabolic	metabolic	JJ
cord-015684-q10sx1dm	273	61	pathway	pathway	NN
cord-015684-q10sx1dm	273	62	.	.	.
cord-015684-q10sx1dm	274	1	Supposing	suppose	VBG
cord-015684-q10sx1dm	274	2	a	a	DT
cord-015684-q10sx1dm	274	3	theoretical	theoretical	JJ
cord-015684-q10sx1dm	274	4	number	number	NN
cord-015684-q10sx1dm	274	5	of	of	IN
cord-015684-q10sx1dm	274	6	100,000	100,000	CD
cord-015684-q10sx1dm	274	7	chemicals	chemical	NNS
cord-015684-q10sx1dm	274	8	in	in	IN
cord-015684-q10sx1dm	274	9	current	current	JJ
cord-015684-q10sx1dm	274	10	use	use	NN
cord-015684-q10sx1dm	274	11	worldwide	worldwide	RB
cord-015684-q10sx1dm	274	12	,	,	,
cord-015684-q10sx1dm	274	13	and	and	CC
cord-015684-q10sx1dm	274	14	assuming	assume	VBG
cord-015684-q10sx1dm	274	15	that	that	IN
cord-015684-q10sx1dm	274	16	practically	practically	RB
cord-015684-q10sx1dm	274	17	all	all	DT
cord-015684-q10sx1dm	274	18	human	human	JJ
cord-015684-q10sx1dm	274	19	genes	gene	NNS
cord-015684-q10sx1dm	274	20	can	can	MD
cord-015684-q10sx1dm	274	21	interact	interact	VB
cord-015684-q10sx1dm	274	22	with	with	IN
cord-015684-q10sx1dm	274	23	drugs	drug	NNS
cord-015684-q10sx1dm	274	24	taken	take	VBN
cord-015684-q10sx1dm	274	25	by	by	IN
cord-015684-q10sx1dm	274	26	human	human	JJ
cord-015684-q10sx1dm	274	27	beings	being	NNS
cord-015684-q10sx1dm	274	28	,	,	,
cord-015684-q10sx1dm	274	29	each	each	DT
cord-015684-q10sx1dm	274	30	gene	gene	NN
cord-015684-q10sx1dm	274	31	in	in	IN
cord-015684-q10sx1dm	274	32	the	the	DT
cord-015684-q10sx1dm	274	33	human	human	JJ
cord-015684-q10sx1dm	274	34	genome	genome	NN
cord-015684-q10sx1dm	274	35	should	should	MD
cord-015684-q10sx1dm	274	36	be	be	VB
cord-015684-q10sx1dm	274	37	involved	involve	VBN
cord-015684-q10sx1dm	274	38	in	in	IN
cord-015684-q10sx1dm	274	39	the	the	DT
cord-015684-q10sx1dm	274	40	metabolism	metabolism	NN
cord-015684-q10sx1dm	274	41	and/or	and/or	CC
cord-015684-q10sx1dm	274	42	biopharmacological	biopharmacological	JJ
cord-015684-q10sx1dm	274	43	effect	effect	NN
cord-015684-q10sx1dm	274	44	of	of	IN
cord-015684-q10sx1dm	274	45	30	30	CD
cord-015684-q10sx1dm	274	46	-	-	SYM
cord-015684-q10sx1dm	274	47	40	40	CD
cord-015684-q10sx1dm	274	48	drugs	drug	NNS
cord-015684-q10sx1dm	274	49	;	;	:
cord-015684-q10sx1dm	274	50	however	however	RB
cord-015684-q10sx1dm	274	51	,	,	,
cord-015684-q10sx1dm	274	52	assuming	assume	VBG
cord-015684-q10sx1dm	274	53	that	that	IN
cord-015684-q10sx1dm	274	54	most	most	JJS
cord-015684-q10sx1dm	274	55	xenobiotic	xenobiotic	JJ
cord-015684-q10sx1dm	274	56	substances	substance	NNS
cord-015684-q10sx1dm	274	57	in	in	IN
cord-015684-q10sx1dm	274	58	contact	contact	NN
cord-015684-q10sx1dm	274	59	with	with	IN
cord-015684-q10sx1dm	274	60	our	-PRON-	PRP$
cord-015684-q10sx1dm	274	61	organism	organism	NN
cord-015684-q10sx1dm	274	62	can	can	MD
cord-015684-q10sx1dm	274	63	infl	infl	VB
cord-015684-q10sx1dm	274	64	uence	uence	NN
cord-015684-q10sx1dm	274	65	genomic	genomic	JJ
cord-015684-q10sx1dm	274	66	function	function	NN
cord-015684-q10sx1dm	274	67	,	,	,
cord-015684-q10sx1dm	274	68	it	-PRON-	PRP
cord-015684-q10sx1dm	274	69	might	may	MD
cord-015684-q10sx1dm	274	70	be	be	VB
cord-015684-q10sx1dm	274	71	possible	possible	JJ
cord-015684-q10sx1dm	274	72	that	that	IN
cord-015684-q10sx1dm	274	73	for	for	IN
cord-015684-q10sx1dm	274	74	1,000,000	1,000,000	CD
cord-015684-q10sx1dm	274	75	xenobiotics	xenobiotic	NNS
cord-015684-q10sx1dm	274	76	in	in	IN
cord-015684-q10sx1dm	274	77	daily	daily	JJ
cord-015684-q10sx1dm	274	78	contact	contact	NN
cord-015684-q10sx1dm	274	79	with	with	IN
cord-015684-q10sx1dm	274	80	humans	human	NNS
cord-015684-q10sx1dm	274	81	,	,	,
cord-015684-q10sx1dm	274	82	an	an	DT
cord-015684-q10sx1dm	274	83	average	average	NN
cord-015684-q10sx1dm	274	84	of	of	IN
cord-015684-q10sx1dm	274	85	350	350	CD
cord-015684-q10sx1dm	274	86	-	-	SYM
cord-015684-q10sx1dm	274	87	500	500	CD
cord-015684-q10sx1dm	274	88	xenobiotics	xenobiotic	NNS
cord-015684-q10sx1dm	274	89	have	have	VBP
cord-015684-q10sx1dm	274	90	to	to	TO
cord-015684-q10sx1dm	274	91	be	be	VB
cord-015684-q10sx1dm	274	92	assigned	assign	VBN
cord-015684-q10sx1dm	274	93	to	to	IN
cord-015684-q10sx1dm	274	94	each	each	DT
cord-015684-q10sx1dm	274	95	one	one	CD
cord-015684-q10sx1dm	274	96	of	of	IN
cord-015684-q10sx1dm	274	97	the	the	DT
cord-015684-q10sx1dm	274	98	genes	gene	NNS
cord-015684-q10sx1dm	274	99	potentially	potentially	RB
cord-015684-q10sx1dm	274	100	involved	involve	VBN
cord-015684-q10sx1dm	274	101	in	in	IN
cord-015684-q10sx1dm	274	102	drug	drug	NN
cord-015684-q10sx1dm	274	103	metabolism	metabolism	NN
cord-015684-q10sx1dm	274	104	and/or	and/or	CC
cord-015684-q10sx1dm	274	105	xenobiotics	xenobiotic	NNS
cord-015684-q10sx1dm	274	106	processing	processing	NN
cord-015684-q10sx1dm	274	107	.	.	.
cord-015684-q10sx1dm	275	1	To	to	IN
cord-015684-q10sx1dm	275	2	fulfi	fulfi	NNP
cord-015684-q10sx1dm	275	3	l	l	NNP
cord-015684-q10sx1dm	275	4	this	this	DT
cord-015684-q10sx1dm	275	5	task	task	NN
cord-015684-q10sx1dm	276	1	a	a	DT
cord-015684-q10sx1dm	276	2	single	single	JJ
cord-015684-q10sx1dm	276	3	gene	gene	NN
cord-015684-q10sx1dm	276	4	has	have	VBZ
cord-015684-q10sx1dm	276	5	to	to	TO
cord-015684-q10sx1dm	276	6	possess	possess	VB
cord-015684-q10sx1dm	276	7	the	the	DT
cord-015684-q10sx1dm	276	8	capacity	capacity	NN
cord-015684-q10sx1dm	276	9	of	of	IN
cord-015684-q10sx1dm	276	10	metabolizing	metabolize	VBG
cord-015684-q10sx1dm	276	11	many	many	JJ
cord-015684-q10sx1dm	276	12	different	different	JJ
cord-015684-q10sx1dm	276	13	xenobiotic	xenobiotic	JJ
cord-015684-q10sx1dm	276	14	substances	substance	NNS
cord-015684-q10sx1dm	276	15	and	and	CC
cord-015684-q10sx1dm	276	16	at	at	IN
cord-015684-q10sx1dm	276	17	the	the	DT
cord-015684-q10sx1dm	276	18	same	same	JJ
cord-015684-q10sx1dm	276	19	time	time	NN
cord-015684-q10sx1dm	276	20	many	many	JJ
cord-015684-q10sx1dm	276	21	different	different	JJ
cord-015684-q10sx1dm	276	22	genes	gene	NNS
cord-015684-q10sx1dm	276	23	have	have	VBP
cord-015684-q10sx1dm	276	24	to	to	TO
cord-015684-q10sx1dm	276	25	cooperate	cooperate	VB
cord-015684-q10sx1dm	276	26	in	in	IN
cord-015684-q10sx1dm	276	27	orchestrated	orchestrate	VBN
cord-015684-q10sx1dm	276	28	networks	network	NNS
cord-015684-q10sx1dm	276	29	to	to	TO
cord-015684-q10sx1dm	276	30	metabolize	metabolize	VB
cord-015684-q10sx1dm	276	31	a	a	DT
cord-015684-q10sx1dm	276	32	particular	particular	JJ
cord-015684-q10sx1dm	276	33	drug	drug	NN
cord-015684-q10sx1dm	276	34	or	or	CC
cord-015684-q10sx1dm	276	35	xenobiotic	xenobiotic	JJ
cord-015684-q10sx1dm	276	36	under	under	IN
cord-015684-q10sx1dm	276	37	sequential	sequential	JJ
cord-015684-q10sx1dm	276	38	biotransformation	biotransformation	NN
cord-015684-q10sx1dm	276	39	steps	step	NNS
cord-015684-q10sx1dm	276	40	(	(	-LRB-
cord-015684-q10sx1dm	276	41	Figs	fig	NNS
cord-015684-q10sx1dm	276	42	.	.	.
cord-015684-q10sx1dm	277	1	40.7	40.7	CD
cord-015684-q10sx1dm	277	2	and	and	CC
cord-015684-q10sx1dm	277	3	40.8	40.8	CD
cord-015684-q10sx1dm	277	4	)	)	-RRB-
cord-015684-q10sx1dm	277	5	.	.	.
cord-015684-q10sx1dm	278	1	Numerous	numerous	JJ
cord-015684-q10sx1dm	278	2	chemicals	chemical	NNS
cord-015684-q10sx1dm	278	3	increase	increase	VBP
cord-015684-q10sx1dm	278	4	the	the	DT
cord-015684-q10sx1dm	278	5	metabolic	metabolic	JJ
cord-015684-q10sx1dm	278	6	capability	capability	NN
cord-015684-q10sx1dm	278	7	of	of	IN
cord-015684-q10sx1dm	278	8	organisms	organism	NNS
cord-015684-q10sx1dm	278	9	by	by	IN
cord-015684-q10sx1dm	278	10	their	-PRON-	PRP$
cord-015684-q10sx1dm	278	11	ability	ability	NN
cord-015684-q10sx1dm	278	12	to	to	TO
cord-015684-q10sx1dm	278	13	activate	activate	VB
cord-015684-q10sx1dm	278	14	genes	gene	NNS
cord-015684-q10sx1dm	278	15	encoding	encode	VBG
cord-015684-q10sx1dm	278	16	various	various	JJ
cord-015684-q10sx1dm	278	17	xenochemical	xenochemical	RB
cord-015684-q10sx1dm	278	18	-	-	HYPH
cord-015684-q10sx1dm	278	19	metabolizing	metabolize	VBG
cord-015684-q10sx1dm	278	20	enzymes	enzyme	NNS
cord-015684-q10sx1dm	278	21	,	,	,
cord-015684-q10sx1dm	278	22	such	such	JJ
cord-015684-q10sx1dm	278	23	as	as	IN
cord-015684-q10sx1dm	278	24	CYPs	cyps	NN
cord-015684-q10sx1dm	278	25	,	,	,
cord-015684-q10sx1dm	278	26	transferases	transferase	NNS
cord-015684-q10sx1dm	278	27	and	and	CC
cord-015684-q10sx1dm	278	28	transporters	transporter	NNS
cord-015684-q10sx1dm	278	29	.	.	.
cord-015684-q10sx1dm	279	1	Many	many	JJ
cord-015684-q10sx1dm	279	2	natural	natural	JJ
cord-015684-q10sx1dm	279	3	and	and	CC
cord-015684-q10sx1dm	279	4	artifi	artifi	NN
cord-015684-q10sx1dm	279	5	cial	cial	JJ
cord-015684-q10sx1dm	279	6	substances	substance	NNS
cord-015684-q10sx1dm	279	7	induce	induce	VBP
cord-015684-q10sx1dm	279	8	the	the	DT
cord-015684-q10sx1dm	279	9	hepatic	hepatic	JJ
cord-015684-q10sx1dm	279	10	CYP	CYP	NNP
cord-015684-q10sx1dm	279	11	subfamilies	subfamily	NNS
cord-015684-q10sx1dm	279	12	in	in	IN
cord-015684-q10sx1dm	279	13	humans	human	NNS
cord-015684-q10sx1dm	279	14	,	,	,
cord-015684-q10sx1dm	279	15	and	and	CC
cord-015684-q10sx1dm	279	16	these	these	DT
cord-015684-q10sx1dm	279	17	inductions	induction	NNS
cord-015684-q10sx1dm	279	18	might	may	MD
cord-015684-q10sx1dm	279	19	lead	lead	VB
cord-015684-q10sx1dm	279	20	to	to	IN
cord-015684-q10sx1dm	279	21	clinically	clinically	RB
cord-015684-q10sx1dm	279	22	important	important	JJ
cord-015684-q10sx1dm	279	23	drug	drug	NN
cord-015684-q10sx1dm	279	24	-	-	HYPH
cord-015684-q10sx1dm	279	25	drug	drug	NN
cord-015684-q10sx1dm	279	26	interactions	interaction	NNS
cord-015684-q10sx1dm	279	27	.	.	.
cord-015684-q10sx1dm	280	1	Some	some	DT
cord-015684-q10sx1dm	280	2	of	of	IN
cord-015684-q10sx1dm	280	3	the	the	DT
cord-015684-q10sx1dm	280	4	key	key	JJ
cord-015684-q10sx1dm	280	5	cellular	cellular	JJ
cord-015684-q10sx1dm	280	6	receptors	receptor	NNS
cord-015684-q10sx1dm	280	7	that	that	WDT
cord-015684-q10sx1dm	280	8	mediate	mediate	VBP
cord-015684-q10sx1dm	280	9	such	such	JJ
cord-015684-q10sx1dm	280	10	inductions	induction	NNS
cord-015684-q10sx1dm	280	11	have	have	VBP
cord-015684-q10sx1dm	280	12	been	be	VBN
cord-015684-q10sx1dm	280	13	recently	recently	RB
cord-015684-q10sx1dm	280	14	identifi	identifi	VBN
cord-015684-q10sx1dm	280	15	ed	ed	NNP
cord-015684-q10sx1dm	280	16	,	,	,
cord-015684-q10sx1dm	280	17	including	include	VBG
cord-015684-q10sx1dm	280	18	nuclear	nuclear	JJ
cord-015684-q10sx1dm	280	19	receptors	receptor	NNS
cord-015684-q10sx1dm	280	20	,	,	,
cord-015684-q10sx1dm	280	21	such	such	JJ
cord-015684-q10sx1dm	280	22	as	as	IN
cord-015684-q10sx1dm	280	23	the	the	DT
cord-015684-q10sx1dm	280	24	constitutive	constitutive	JJ
cord-015684-q10sx1dm	280	25	androstane	androstane	NN
cord-015684-q10sx1dm	280	26	receptor	receptor	NN
cord-015684-q10sx1dm	280	27	(	(	-LRB-
cord-015684-q10sx1dm	280	28	CAR	car	NN
cord-015684-q10sx1dm	280	29	,	,	,
cord-015684-q10sx1dm	280	30	NR1I3	NR1I3	NNP
cord-015684-q10sx1dm	280	31	)	)	-RRB-
cord-015684-q10sx1dm	280	32	,	,	,
cord-015684-q10sx1dm	280	33	the	the	DT
cord-015684-q10sx1dm	280	34	retinoid	retinoid	NN
cord-015684-q10sx1dm	280	35	X	x	NN
cord-015684-q10sx1dm	280	36	receptor	receptor	NN
cord-015684-q10sx1dm	280	37	(	(	-LRB-
cord-015684-q10sx1dm	280	38	RXR	rxr	UH
cord-015684-q10sx1dm	280	39	,	,	,
cord-015684-q10sx1dm	280	40	NR2B1	NR2B1	NNP
cord-015684-q10sx1dm	280	41	)	)	-RRB-
cord-015684-q10sx1dm	280	42	,	,	,
cord-015684-q10sx1dm	280	43	the	the	DT
cord-015684-q10sx1dm	280	44	pregnane	pregnane	NNP
cord-015684-q10sx1dm	280	45	X	X	NNP
cord-015684-q10sx1dm	280	46	receptor	receptor	NN
cord-015684-q10sx1dm	280	47	(	(	-LRB-
cord-015684-q10sx1dm	280	48	PXR	PXR	NNP
cord-015684-q10sx1dm	280	49	,	,	,
cord-015684-q10sx1dm	280	50	NR1I3	NR1I3	NNP
cord-015684-q10sx1dm	280	51	)	)	-RRB-
cord-015684-q10sx1dm	280	52	,	,	,
cord-015684-q10sx1dm	280	53	and	and	CC
cord-015684-q10sx1dm	280	54	the	the	DT
cord-015684-q10sx1dm	280	55	vitamin	vitamin	NN
cord-015684-q10sx1dm	280	56	D	d	NN
cord-015684-q10sx1dm	280	57	receptor	receptor	NN
cord-015684-q10sx1dm	280	58	(	(	-LRB-
cord-015684-q10sx1dm	280	59	VDR	VDR	NNP
cord-015684-q10sx1dm	280	60	,	,	,
cord-015684-q10sx1dm	280	61	NR1I1	nr1i1	NN
cord-015684-q10sx1dm	280	62	)	)	-RRB-
cord-015684-q10sx1dm	280	63	and	and	CC
cord-015684-q10sx1dm	280	64	steroid	steroid	NN
cord-015684-q10sx1dm	280	65	receptors	receptor	NNS
cord-015684-q10sx1dm	280	66	such	such	JJ
cord-015684-q10sx1dm	280	67	as	as	IN
cord-015684-q10sx1dm	280	68	the	the	DT
cord-015684-q10sx1dm	280	69	glucocorticoid	glucocorticoid	NN
cord-015684-q10sx1dm	280	70	receptor	receptor	NN
cord-015684-q10sx1dm	280	71	(	(	-LRB-
cord-015684-q10sx1dm	280	72	GR	GR	NNP
cord-015684-q10sx1dm	280	73	,	,	,
cord-015684-q10sx1dm	280	74	NR3C1	NR3C1	NNP
cord-015684-q10sx1dm	280	75	)	)	-RRB-
cord-015684-q10sx1dm	280	76	.	.	.
cord-015684-q10sx1dm	281	1	97	97	CD
cord-015684-q10sx1dm	282	1	There	there	EX
cord-015684-q10sx1dm	282	2	is	be	VBZ
cord-015684-q10sx1dm	282	3	a	a	DT
cord-015684-q10sx1dm	282	4	wide	wide	JJ
cord-015684-q10sx1dm	282	5	promiscuity	promiscuity	NN
cord-015684-q10sx1dm	282	6	of	of	IN
cord-015684-q10sx1dm	282	7	these	these	DT
cord-015684-q10sx1dm	282	8	receptors	receptor	NNS
cord-015684-q10sx1dm	282	9	in	in	IN
cord-015684-q10sx1dm	282	10	the	the	DT
cord-015684-q10sx1dm	282	11	induction	induction	NN
cord-015684-q10sx1dm	282	12	of	of	IN
cord-015684-q10sx1dm	282	13	CYPs	cyps	NN
cord-015684-q10sx1dm	282	14	in	in	IN
cord-015684-q10sx1dm	282	15	response	response	NN
cord-015684-q10sx1dm	282	16	to	to	IN
cord-015684-q10sx1dm	282	17	xenobiotics	xenobiotic	NNS
cord-015684-q10sx1dm	282	18	.	.	.
cord-015684-q10sx1dm	283	1	Indeed	indeed	RB
cord-015684-q10sx1dm	283	2	,	,	,
cord-015684-q10sx1dm	283	3	this	this	DT
cord-015684-q10sx1dm	283	4	adaptive	adaptive	JJ
cord-015684-q10sx1dm	283	5	system	system	NN
cord-015684-q10sx1dm	283	6	acts	act	VBZ
cord-015684-q10sx1dm	283	7	as	as	IN
cord-015684-q10sx1dm	283	8	an	an	DT
cord-015684-q10sx1dm	283	9	effective	effective	JJ
cord-015684-q10sx1dm	283	10	network	network	NN
cord-015684-q10sx1dm	283	11	where	where	WRB
cord-015684-q10sx1dm	283	12	receptors	receptor	NNS
cord-015684-q10sx1dm	283	13	share	share	VBP
cord-015684-q10sx1dm	283	14	partners	partner	NNS
cord-015684-q10sx1dm	283	15	,	,	,
cord-015684-q10sx1dm	283	16	ligands	ligand	NNS
cord-015684-q10sx1dm	283	17	,	,	,
cord-015684-q10sx1dm	283	18	DNA	dna	NN
cord-015684-q10sx1dm	283	19	response	response	NN
cord-015684-q10sx1dm	283	20	elements	element	NNS
cord-015684-q10sx1dm	283	21	and	and	CC
cord-015684-q10sx1dm	283	22	target	target	NN
cord-015684-q10sx1dm	283	23	genes	gene	NNS
cord-015684-q10sx1dm	283	24	,	,	,
cord-015684-q10sx1dm	283	25	infl	infl	NNP
cord-015684-q10sx1dm	283	26	uencing	uence	VBG
cord-015684-q10sx1dm	283	27	their	-PRON-	PRP$
cord-015684-q10sx1dm	283	28	mutual	mutual	JJ
cord-015684-q10sx1dm	283	29	relative	relative	JJ
cord-015684-q10sx1dm	283	30	expression	expression	NN
cord-015684-q10sx1dm	283	31	.	.	.
cord-015684-q10sx1dm	284	1	97,98	97,98	NFP
cord-015684-q10sx1dm	284	2	The	the	DT
cord-015684-q10sx1dm	284	3	most	most	RBS
cord-015684-q10sx1dm	284	4	important	important	JJ
cord-015684-q10sx1dm	284	5	enzymes	enzyme	NNS
cord-015684-q10sx1dm	284	6	of	of	IN
cord-015684-q10sx1dm	284	7	the	the	DT
cord-015684-q10sx1dm	284	8	P450	P450	NNP
cord-015684-q10sx1dm	284	9	cytochrome	cytochrome	NN
cord-015684-q10sx1dm	284	10	family	family	NN
cord-015684-q10sx1dm	284	11	in	in	IN
cord-015684-q10sx1dm	284	12	drug	drug	NN
cord-015684-q10sx1dm	284	13	metabolism	metabolism	NN
cord-015684-q10sx1dm	284	14	by	by	IN
cord-015684-q10sx1dm	284	15	decreasing	decrease	VBG
cord-015684-q10sx1dm	284	16	order	order	NN
cord-015684-q10sx1dm	284	17	are	be	VBP
cord-015684-q10sx1dm	284	18	CYP3A4	cyp3a4	JJ
cord-015684-q10sx1dm	284	19	,	,	,
cord-015684-q10sx1dm	284	20	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	284	21	,	,	,
cord-015684-q10sx1dm	284	22	CYP2C9	CYP2C9	NNP
cord-015684-q10sx1dm	284	23	,	,	,
cord-015684-q10sx1dm	284	24	CYP2C19	CYP2C19	NNP
cord-015684-q10sx1dm	284	25	,	,	,
cord-015684-q10sx1dm	284	26	and	and	CC
cord-015684-q10sx1dm	284	27	CYP2A6	CYP2A6	NNP
cord-015684-q10sx1dm	284	28	.	.	.
cord-015684-q10sx1dm	285	1	[	[	-LRB-
cord-015684-q10sx1dm	285	2	85	85	CD
cord-015684-q10sx1dm	285	3	]	]	-RRB-
cord-015684-q10sx1dm	285	4	[	[	-LRB-
cord-015684-q10sx1dm	285	5	86	86	CD
cord-015684-q10sx1dm	285	6	]	]	-RRB-
cord-015684-q10sx1dm	286	1	[	[	-LRB-
cord-015684-q10sx1dm	286	2	87	87	CD
cord-015684-q10sx1dm	286	3	]	]	-RRB-
cord-015684-q10sx1dm	286	4	94	94	CD
cord-015684-q10sx1dm	286	5	,	,	,
cord-015684-q10sx1dm	286	6	99	99	CD
cord-015684-q10sx1dm	286	7	,	,	,
cord-015684-q10sx1dm	286	8	100	100	CD
cord-015684-q10sx1dm	287	1	The	the	DT
cord-015684-q10sx1dm	287	2	predominant	predominant	JJ
cord-015684-q10sx1dm	287	3	allelic	allelic	JJ
cord-015684-q10sx1dm	287	4	variants	variant	NNS
cord-015684-q10sx1dm	287	5	in	in	IN
cord-015684-q10sx1dm	287	6	the	the	DT
cord-015684-q10sx1dm	287	7	CYP2A6	CYP2A6	NNP
cord-015684-q10sx1dm	287	8	gene	gene	NN
cord-015684-q10sx1dm	287	9	are	be	VBP
cord-015684-q10sx1dm	287	10	CYP2A6	CYP2A6	NNP
cord-015684-q10sx1dm	287	11	*	*	SYM
cord-015684-q10sx1dm	287	12	2	2	CD
cord-015684-q10sx1dm	287	13	(	(	-LRB-
cord-015684-q10sx1dm	287	14	Leu160His	Leu160His	NNP
cord-015684-q10sx1dm	287	15	)	)	-RRB-
cord-015684-q10sx1dm	287	16	and	and	CC
cord-015684-q10sx1dm	287	17	CYP2A6del	CYP2A6del	NNP
cord-015684-q10sx1dm	287	18	.	.	.
cord-015684-q10sx1dm	288	1	The	the	DT
cord-015684-q10sx1dm	288	2	CYP2A6	CYP2A6	NNP
cord-015684-q10sx1dm	288	3	*	*	SYM
cord-015684-q10sx1dm	288	4	2	2	CD
cord-015684-q10sx1dm	288	5	mutation	mutation	NN
cord-015684-q10sx1dm	288	6	inactivates	inactivate	VBZ
cord-015684-q10sx1dm	288	7	the	the	DT
cord-015684-q10sx1dm	288	8	enzyme	enzyme	NN
cord-015684-q10sx1dm	288	9	and	and	CC
cord-015684-q10sx1dm	288	10	is	be	VBZ
cord-015684-q10sx1dm	288	11	present	present	JJ
cord-015684-q10sx1dm	288	12	in	in	IN
cord-015684-q10sx1dm	288	13	1	1	CD
cord-015684-q10sx1dm	288	14	-	-	SYM
cord-015684-q10sx1dm	288	15	3	3	CD
cord-015684-q10sx1dm	288	16	%	%	NN
cord-015684-q10sx1dm	288	17	of	of	IN
cord-015684-q10sx1dm	288	18	Caucasians	Caucasians	NNPS
cord-015684-q10sx1dm	288	19	.	.	.
cord-015684-q10sx1dm	289	1	The	the	DT
cord-015684-q10sx1dm	289	2	CYP2A6del	CYP2A6del	NNP
cord-015684-q10sx1dm	289	3	mutation	mutation	NN
cord-015684-q10sx1dm	289	4	results	result	VBZ
cord-015684-q10sx1dm	289	5	in	in	IN
cord-015684-q10sx1dm	289	6	no	no	DT
cord-015684-q10sx1dm	289	7	enzyme	enzyme	NN
cord-015684-q10sx1dm	289	8	activity	activity	NN
cord-015684-q10sx1dm	289	9	and	and	CC
cord-015684-q10sx1dm	289	10	is	be	VBZ
cord-015684-q10sx1dm	289	11	present	present	JJ
cord-015684-q10sx1dm	289	12	in	in	IN
cord-015684-q10sx1dm	289	13	1	1	CD
cord-015684-q10sx1dm	289	14	%	%	NN
cord-015684-q10sx1dm	289	15	of	of	IN
cord-015684-q10sx1dm	289	16	Caucasians	Caucasians	NNPS
cord-015684-q10sx1dm	289	17	and	and	CC
cord-015684-q10sx1dm	289	18	15	15	CD
cord-015684-q10sx1dm	289	19	%	%	NN
cord-015684-q10sx1dm	289	20	of	of	IN
cord-015684-q10sx1dm	289	21	Asians	Asians	NNPS
cord-015684-q10sx1dm	289	22	.	.	.
cord-015684-q10sx1dm	290	1	[	[	-LRB-
cord-015684-q10sx1dm	290	2	18	18	CD
cord-015684-q10sx1dm	290	3	]	]	-RRB-
cord-015684-q10sx1dm	290	4	[	[	-LRB-
cord-015684-q10sx1dm	290	5	19	19	CD
cord-015684-q10sx1dm	290	6	]	]	-RRB-
cord-015684-q10sx1dm	290	7	[	[	-LRB-
cord-015684-q10sx1dm	290	8	20	20	CD
cord-015684-q10sx1dm	290	9	]	]	-RRB-
cord-015684-q10sx1dm	290	10	86	86	CD
cord-015684-q10sx1dm	291	1	The	the	DT
cord-015684-q10sx1dm	291	2	most	most	RBS
cord-015684-q10sx1dm	291	3	frequent	frequent	JJ
cord-015684-q10sx1dm	291	4	mutations	mutation	NNS
cord-015684-q10sx1dm	291	5	in	in	IN
cord-015684-q10sx1dm	291	6	the	the	DT
cord-015684-q10sx1dm	291	7	CYP2C9	CYP2C9	NNP
cord-015684-q10sx1dm	291	8	gene	gene	NN
cord-015684-q10sx1dm	291	9	are	be	VBP
cord-015684-q10sx1dm	291	10	CYP2C9	CYP2C9	NNP
cord-015684-q10sx1dm	291	11	*	*	NFP
cord-015684-q10sx1dm	291	12	2	2	CD
cord-015684-q10sx1dm	291	13	(	(	-LRB-
cord-015684-q10sx1dm	291	14	Arg144Cys	Arg144Cys	NNP
cord-015684-q10sx1dm	291	15	)	)	-RRB-
cord-015684-q10sx1dm	291	16	,	,	,
cord-015684-q10sx1dm	291	17	with	with	IN
cord-015684-q10sx1dm	291	18	reduced	reduce	VBN
cord-015684-q10sx1dm	291	19	affi	affi	NNP
cord-015684-q10sx1dm	291	20	nity	nity	NN
cord-015684-q10sx1dm	291	21	for	for	IN
cord-015684-q10sx1dm	291	22	P450	P450	NNPS
cord-015684-q10sx1dm	291	23	in	in	IN
cord-015684-q10sx1dm	291	24	8	8	CD
cord-015684-q10sx1dm	291	25	-	-	SYM
cord-015684-q10sx1dm	291	26	13	13	CD
cord-015684-q10sx1dm	291	27	%	%	NN
cord-015684-q10sx1dm	291	28	of	of	IN
cord-015684-q10sx1dm	291	29	Caucasians	Caucasians	NNPS
cord-015684-q10sx1dm	291	30	,	,	,
cord-015684-q10sx1dm	291	31	and	and	CC
cord-015684-q10sx1dm	291	32	CYP2C9	CYP2C9	NNP
cord-015684-q10sx1dm	291	33	*	*	NFP
cord-015684-q10sx1dm	291	34	3	3	CD
cord-015684-q10sx1dm	291	35	(	(	-LRB-
cord-015684-q10sx1dm	291	36	Ile359Leu	ile359leu	CD
cord-015684-q10sx1dm	291	37	)	)	-RRB-
cord-015684-q10sx1dm	291	38	,	,	,
cord-015684-q10sx1dm	291	39	with	with	IN
cord-015684-q10sx1dm	291	40	alterations	alteration	NNS
cord-015684-q10sx1dm	291	41	in	in	IN
cord-015684-q10sx1dm	291	42	the	the	DT
cord-015684-q10sx1dm	291	43	specifi	specifi	NN
cord-015684-q10sx1dm	291	44	city	city	NN
cord-015684-q10sx1dm	291	45	for	for	IN
cord-015684-q10sx1dm	291	46	the	the	DT
cord-015684-q10sx1dm	291	47	substrate	substrate	NN
cord-015684-q10sx1dm	291	48	in	in	IN
cord-015684-q10sx1dm	291	49	6	6	CD
cord-015684-q10sx1dm	291	50	-	-	SYM
cord-015684-q10sx1dm	291	51	9	9	CD
cord-015684-q10sx1dm	291	52	%	%	NN
cord-015684-q10sx1dm	291	53	of	of	IN
cord-015684-q10sx1dm	291	54	Caucasians	Caucasians	NNPS
cord-015684-q10sx1dm	291	55	and	and	CC
cord-015684-q10sx1dm	291	56	2	2	CD
cord-015684-q10sx1dm	291	57	-	-	SYM
cord-015684-q10sx1dm	291	58	3	3	CD
cord-015684-q10sx1dm	291	59	%	%	NN
cord-015684-q10sx1dm	291	60	of	of	IN
cord-015684-q10sx1dm	291	61	Asians	Asians	NNPS
cord-015684-q10sx1dm	291	62	.	.	.
cord-015684-q10sx1dm	292	1	[	[	-LRB-
cord-015684-q10sx1dm	292	2	18	18	CD
cord-015684-q10sx1dm	292	3	]	]	-RRB-
cord-015684-q10sx1dm	292	4	[	[	-LRB-
cord-015684-q10sx1dm	292	5	19	19	CD
cord-015684-q10sx1dm	292	6	]	]	-RRB-
cord-015684-q10sx1dm	292	7	[	[	-LRB-
cord-015684-q10sx1dm	292	8	20	20	CD
cord-015684-q10sx1dm	292	9	]	]	-RRB-
cord-015684-q10sx1dm	292	10	86	86	CD
cord-015684-q10sx1dm	293	1	The	the	DT
cord-015684-q10sx1dm	293	2	most	most	RBS
cord-015684-q10sx1dm	293	3	prevalent	prevalent	JJ
cord-015684-q10sx1dm	293	4	polymorphic	polymorphic	JJ
cord-015684-q10sx1dm	293	5	variants	variant	NNS
cord-015684-q10sx1dm	293	6	in	in	IN
cord-015684-q10sx1dm	293	7	the	the	DT
cord-015684-q10sx1dm	293	8	CYP2C19	CYP2C19	NNP
cord-015684-q10sx1dm	293	9	gene	gene	NN
cord-015684-q10sx1dm	293	10	are	be	VBP
cord-015684-q10sx1dm	294	1	CYP2C19	CYP2C19	NNP
cord-015684-q10sx1dm	295	1	*	*	NFP
cord-015684-q10sx1dm	295	2	2	2	CD
cord-015684-q10sx1dm	295	3	,	,	,
cord-015684-q10sx1dm	295	4	with	with	IN
cord-015684-q10sx1dm	295	5	an	an	DT
cord-015684-q10sx1dm	295	6	aberrant	aberrant	JJ
cord-015684-q10sx1dm	295	7	splicing	splicing	NN
cord-015684-q10sx1dm	295	8	site	site	NN
cord-015684-q10sx1dm	295	9	resulting	result	VBG
cord-015684-q10sx1dm	295	10	in	in	IN
cord-015684-q10sx1dm	295	11	enzyme	enzyme	NN
cord-015684-q10sx1dm	295	12	inactivation	inactivation	NN
cord-015684-q10sx1dm	295	13	in	in	IN
cord-015684-q10sx1dm	295	14	13	13	CD
cord-015684-q10sx1dm	295	15	%	%	NN
cord-015684-q10sx1dm	295	16	of	of	IN
cord-015684-q10sx1dm	295	17	Caucasians	Caucasians	NNPS
cord-015684-q10sx1dm	295	18	,	,	,
cord-015684-q10sx1dm	295	19	23	23	CD
cord-015684-q10sx1dm	295	20	-	-	SYM
cord-015684-q10sx1dm	295	21	32	32	CD
cord-015684-q10sx1dm	295	22	%	%	NN
cord-015684-q10sx1dm	295	23	of	of	IN
cord-015684-q10sx1dm	295	24	Asians	Asians	NNPS
cord-015684-q10sx1dm	295	25	,	,	,
cord-015684-q10sx1dm	295	26	13	13	CD
cord-015684-q10sx1dm	295	27	%	%	NN
cord-015684-q10sx1dm	295	28	of	of	IN
cord-015684-q10sx1dm	295	29	Africans	Africans	NNPS
cord-015684-q10sx1dm	295	30	,	,	,
cord-015684-q10sx1dm	295	31	and	and	CC
cord-015684-q10sx1dm	295	32	14	14	CD
cord-015684-q10sx1dm	295	33	-	-	SYM
cord-015684-q10sx1dm	295	34	15	15	CD
cord-015684-q10sx1dm	295	35	%	%	NN
cord-015684-q10sx1dm	295	36	of	of	IN
cord-015684-q10sx1dm	295	37	Ethiopians	Ethiopians	NNPS
cord-015684-q10sx1dm	295	38	and	and	CC
cord-015684-q10sx1dm	295	39	Saoudians	Saoudians	NNPS
cord-015684-q10sx1dm	295	40	,	,	,
cord-015684-q10sx1dm	295	41	and	and	CC
cord-015684-q10sx1dm	295	42	CYP2C19	CYP2C19	NNP
cord-015684-q10sx1dm	295	43	*	*	NFP
cord-015684-q10sx1dm	295	44	3	3	CD
cord-015684-q10sx1dm	295	45	,	,	,
cord-015684-q10sx1dm	295	46	a	a	DT
cord-015684-q10sx1dm	295	47	premature	premature	JJ
cord-015684-q10sx1dm	295	48	stop	stop	NN
cord-015684-q10sx1dm	295	49	codon	codon	NN
cord-015684-q10sx1dm	295	50	resulting	result	VBG
cord-015684-q10sx1dm	295	51	in	in	IN
cord-015684-q10sx1dm	295	52	an	an	DT
cord-015684-q10sx1dm	295	53	inactive	inactive	JJ
cord-015684-q10sx1dm	295	54	enzyme	enzyme	NN
cord-015684-q10sx1dm	295	55	present	present	NN
cord-015684-q10sx1dm	295	56	in	in	IN
cord-015684-q10sx1dm	295	57	6	6	CD
cord-015684-q10sx1dm	295	58	-	-	SYM
cord-015684-q10sx1dm	295	59	10	10	CD
cord-015684-q10sx1dm	295	60	%	%	NN
cord-015684-q10sx1dm	295	61	of	of	IN
cord-015684-q10sx1dm	295	62	Asians	Asians	NNPS
cord-015684-q10sx1dm	295	63	,	,	,
cord-015684-q10sx1dm	295	64	and	and	CC
cord-015684-q10sx1dm	295	65	almost	almost	RB
cord-015684-q10sx1dm	295	66	absent	absent	JJ
cord-015684-q10sx1dm	295	67	in	in	IN
cord-015684-q10sx1dm	295	68	Caucasians	Caucasians	NNPS
cord-015684-q10sx1dm	295	69	.	.	.
cord-015684-q10sx1dm	296	1	[	[	-LRB-
cord-015684-q10sx1dm	296	2	18	18	CD
cord-015684-q10sx1dm	296	3	]	]	-RRB-
cord-015684-q10sx1dm	296	4	[	[	-LRB-
cord-015684-q10sx1dm	296	5	19	19	CD
cord-015684-q10sx1dm	296	6	]	]	-RRB-
cord-015684-q10sx1dm	296	7	[	[	-LRB-
cord-015684-q10sx1dm	296	8	20	20	CD
cord-015684-q10sx1dm	296	9	]	]	-RRB-
cord-015684-q10sx1dm	296	10	86	86	CD
cord-015684-q10sx1dm	296	11	,	,	,
cord-015684-q10sx1dm	296	12	101	101	CD
cord-015684-q10sx1dm	297	1	The	the	DT
cord-015684-q10sx1dm	297	2	most	most	RBS
cord-015684-q10sx1dm	297	3	important	important	JJ
cord-015684-q10sx1dm	297	4	mutations	mutation	NNS
cord-015684-q10sx1dm	297	5	in	in	IN
cord-015684-q10sx1dm	297	6	the	the	DT
cord-015684-q10sx1dm	297	7	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	297	8	gene	gene	NN
cord-015684-q10sx1dm	297	9	are	be	VBP
cord-015684-q10sx1dm	297	10	the	the	DT
cord-015684-q10sx1dm	297	11	following	follow	VBG
cord-015684-q10sx1dm	297	12	:	:	:
cord-015684-q10sx1dm	297	13	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	297	14	*	*	NFP
cord-015684-q10sx1dm	297	15	2xN	2xn	CD
cord-015684-q10sx1dm	297	16	,	,	,
cord-015684-q10sx1dm	297	17	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	297	18	*	*	NFP
cord-015684-q10sx1dm	297	19	4	4	CD
cord-015684-q10sx1dm	297	20	,	,	,
cord-015684-q10sx1dm	297	21	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	297	22	*	*	NFP
cord-015684-q10sx1dm	297	23	5	5	CD
cord-015684-q10sx1dm	297	24	,	,	,
cord-015684-q10sx1dm	297	25	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	297	26	*	*	NFP
cord-015684-q10sx1dm	297	27	10	10	CD
cord-015684-q10sx1dm	297	28	and	and	CC
cord-015684-q10sx1dm	297	29	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	297	30	*	*	NFP
cord-015684-q10sx1dm	297	31	17	17	CD
cord-015684-q10sx1dm	297	32	.	.	.
cord-015684-q10sx1dm	298	1	[	[	-LRB-
cord-015684-q10sx1dm	298	2	18	18	CD
cord-015684-q10sx1dm	298	3	]	]	-RRB-
cord-015684-q10sx1dm	298	4	[	[	-LRB-
cord-015684-q10sx1dm	298	5	19	19	CD
cord-015684-q10sx1dm	298	6	]	]	-RRB-
cord-015684-q10sx1dm	298	7	[	[	-LRB-
cord-015684-q10sx1dm	298	8	20	20	CD
cord-015684-q10sx1dm	298	9	]	]	-RRB-
cord-015684-q10sx1dm	298	10	96	96	CD
cord-015684-q10sx1dm	298	11	,	,	,
cord-015684-q10sx1dm	298	12	102	102	CD
cord-015684-q10sx1dm	299	1	The	the	DT
cord-015684-q10sx1dm	299	2	CYP2D6	CYP2D6	NNPS
cord-015684-q10sx1dm	299	3	*	*	NFP
cord-015684-q10sx1dm	299	4	2xN	2xn	CD
cord-015684-q10sx1dm	299	5	mutation	mutation	NN
cord-015684-q10sx1dm	299	6	gives	give	VBZ
cord-015684-q10sx1dm	299	7	rise	rise	NN
cord-015684-q10sx1dm	299	8	to	to	IN
cord-015684-q10sx1dm	299	9	a	a	DT
cord-015684-q10sx1dm	299	10	gene	gene	NN
cord-015684-q10sx1dm	299	11	duplication	duplication	NN
cord-015684-q10sx1dm	299	12	or	or	CC
cord-015684-q10sx1dm	299	13	multiplication	multiplication	NN
cord-015684-q10sx1dm	299	14	resulting	result	VBG
cord-015684-q10sx1dm	299	15	in	in	IN
cord-015684-q10sx1dm	299	16	an	an	DT
cord-015684-q10sx1dm	299	17	increased	increase	VBN
cord-015684-q10sx1dm	299	18	enzyme	enzyme	NN
cord-015684-q10sx1dm	299	19	activity	activity	NN
cord-015684-q10sx1dm	299	20	which	which	WDT
cord-015684-q10sx1dm	299	21	appears	appear	VBZ
cord-015684-q10sx1dm	299	22	in	in	IN
cord-015684-q10sx1dm	299	23	1	1	CD
cord-015684-q10sx1dm	299	24	-	-	SYM
cord-015684-q10sx1dm	299	25	5	5	CD
cord-015684-q10sx1dm	299	26	%	%	NN
cord-015684-q10sx1dm	299	27	of	of	IN
cord-015684-q10sx1dm	299	28	the	the	DT
cord-015684-q10sx1dm	299	29	Caucasian	caucasian	JJ
cord-015684-q10sx1dm	299	30	population	population	NN
cord-015684-q10sx1dm	299	31	,	,	,
cord-015684-q10sx1dm	299	32	0	0	CD
cord-015684-q10sx1dm	299	33	-	-	SYM
cord-015684-q10sx1dm	299	34	2	2	CD
cord-015684-q10sx1dm	299	35	%	%	NN
cord-015684-q10sx1dm	299	36	of	of	IN
cord-015684-q10sx1dm	299	37	Asians	Asians	NNPS
cord-015684-q10sx1dm	299	38	,	,	,
cord-015684-q10sx1dm	299	39	2	2	CD
cord-015684-q10sx1dm	299	40	%	%	NN
cord-015684-q10sx1dm	299	41	of	of	IN
cord-015684-q10sx1dm	299	42	Africans	Africans	NNPS
cord-015684-q10sx1dm	299	43	,	,	,
cord-015684-q10sx1dm	299	44	and	and	CC
cord-015684-q10sx1dm	299	45	10	10	CD
cord-015684-q10sx1dm	299	46	-	-	SYM
cord-015684-q10sx1dm	299	47	16	16	CD
cord-015684-q10sx1dm	299	48	%	%	NN
cord-015684-q10sx1dm	299	49	of	of	IN
cord-015684-q10sx1dm	299	50	Ethiopians	Ethiopians	NNPS
cord-015684-q10sx1dm	299	51	.	.	.
cord-015684-q10sx1dm	300	1	The	the	DT
cord-015684-q10sx1dm	300	2	defective	defective	JJ
cord-015684-q10sx1dm	300	3	splicing	splicing	NN
cord-015684-q10sx1dm	300	4	caused	cause	VBN
cord-015684-q10sx1dm	300	5	by	by	IN
cord-015684-q10sx1dm	300	6	the	the	DT
cord-015684-q10sx1dm	300	7	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	300	8	*	*	NFP
cord-015684-q10sx1dm	300	9	4	4	CD
cord-015684-q10sx1dm	300	10	mutation	mutation	NN
cord-015684-q10sx1dm	300	11	inactivates	inactivate	VBZ
cord-015684-q10sx1dm	300	12	the	the	DT
cord-015684-q10sx1dm	300	13	enzyme	enzyme	NN
cord-015684-q10sx1dm	300	14	and	and	CC
cord-015684-q10sx1dm	300	15	is	be	VBZ
cord-015684-q10sx1dm	300	16	present	present	JJ
cord-015684-q10sx1dm	300	17	in	in	IN
cord-015684-q10sx1dm	300	18	12	12	CD
cord-015684-q10sx1dm	300	19	-	-	SYM
cord-015684-q10sx1dm	300	20	21	21	CD
cord-015684-q10sx1dm	300	21	%	%	NN
cord-015684-q10sx1dm	300	22	of	of	IN
cord-015684-q10sx1dm	300	23	Caucasians	Caucasians	NNPS
cord-015684-q10sx1dm	300	24	.	.	.
cord-015684-q10sx1dm	301	1	The	the	DT
cord-015684-q10sx1dm	301	2	deletion	deletion	NN
cord-015684-q10sx1dm	301	3	in	in	IN
cord-015684-q10sx1dm	301	4	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	301	5	*	*	NFP
cord-015684-q10sx1dm	301	6	5	5	CD
cord-015684-q10sx1dm	301	7	abolishes	abolish	VBZ
cord-015684-q10sx1dm	301	8	enzyme	enzyme	NN
cord-015684-q10sx1dm	301	9	activity	activity	NN
cord-015684-q10sx1dm	301	10	and	and	CC
cord-015684-q10sx1dm	301	11	shows	show	VBZ
cord-015684-q10sx1dm	301	12	a	a	DT
cord-015684-q10sx1dm	301	13	frequency	frequency	NN
cord-015684-q10sx1dm	301	14	of	of	IN
cord-015684-q10sx1dm	301	15	2	2	CD
cord-015684-q10sx1dm	301	16	-	-	SYM
cord-015684-q10sx1dm	301	17	7	7	CD
cord-015684-q10sx1dm	301	18	%	%	NN
cord-015684-q10sx1dm	301	19	in	in	IN
cord-015684-q10sx1dm	301	20	Caucasians	Caucasians	NNPS
cord-015684-q10sx1dm	301	21	,	,	,
cord-015684-q10sx1dm	301	22	1	1	CD
cord-015684-q10sx1dm	301	23	%	%	NN
cord-015684-q10sx1dm	301	24	in	in	IN
cord-015684-q10sx1dm	301	25	Asians	Asians	NNPS
cord-015684-q10sx1dm	301	26	,	,	,
cord-015684-q10sx1dm	301	27	2	2	CD
cord-015684-q10sx1dm	301	28	%	%	NN
cord-015684-q10sx1dm	301	29	in	in	IN
cord-015684-q10sx1dm	301	30	Africans	Africans	NNPS
cord-015684-q10sx1dm	301	31	,	,	,
cord-015684-q10sx1dm	301	32	and	and	CC
cord-015684-q10sx1dm	301	33	1	1	CD
cord-015684-q10sx1dm	301	34	-	-	SYM
cord-015684-q10sx1dm	301	35	3	3	CD
cord-015684-q10sx1dm	301	36	%	%	NN
cord-015684-q10sx1dm	301	37	in	in	IN
cord-015684-q10sx1dm	301	38	Ethiopians	Ethiopians	NNPS
cord-015684-q10sx1dm	301	39	.	.	.
cord-015684-q10sx1dm	302	1	The	the	DT
cord-015684-q10sx1dm	302	2	polymorphism	polymorphism	NN
cord-015684-q10sx1dm	302	3	CYP2D6	cyp2d6	VBP
cord-015684-q10sx1dm	302	4	*	*	NFP
cord-015684-q10sx1dm	302	5	10	10	CD
cord-015684-q10sx1dm	302	6	causes	cause	NNS
cord-015684-q10sx1dm	302	7	Pro34Ser	Pro34Ser	NNP
cord-015684-q10sx1dm	302	8	and	and	CC
cord-015684-q10sx1dm	302	9	Ser486Thr	ser486thr	CD
cord-015684-q10sx1dm	302	10	mutations	mutation	NNS
cord-015684-q10sx1dm	302	11	with	with	IN
cord-015684-q10sx1dm	302	12	unstable	unstable	JJ
cord-015684-q10sx1dm	302	13	enzyme	enzyme	NN
cord-015684-q10sx1dm	302	14	activity	activity	NN
cord-015684-q10sx1dm	302	15	in	in	IN
cord-015684-q10sx1dm	302	16	1	1	CD
cord-015684-q10sx1dm	302	17	-	-	SYM
cord-015684-q10sx1dm	302	18	2	2	CD
cord-015684-q10sx1dm	302	19	%	%	NN
cord-015684-q10sx1dm	302	20	of	of	IN
cord-015684-q10sx1dm	302	21	Caucasians	Caucasians	NNPS
cord-015684-q10sx1dm	302	22	,	,	,
cord-015684-q10sx1dm	302	23	6	6	CD
cord-015684-q10sx1dm	302	24	%	%	NN
cord-015684-q10sx1dm	302	25	of	of	IN
cord-015684-q10sx1dm	302	26	Asians	Asians	NNPS
cord-015684-q10sx1dm	302	27	,	,	,
cord-015684-q10sx1dm	302	28	4	4	CD
cord-015684-q10sx1dm	302	29	%	%	NN
cord-015684-q10sx1dm	302	30	of	of	IN
cord-015684-q10sx1dm	302	31	Africans	Africans	NNPS
cord-015684-q10sx1dm	302	32	,	,	,
cord-015684-q10sx1dm	302	33	and	and	CC
cord-015684-q10sx1dm	302	34	1	1	CD
cord-015684-q10sx1dm	302	35	-	-	SYM
cord-015684-q10sx1dm	302	36	3	3	CD
cord-015684-q10sx1dm	302	37	%	%	NN
cord-015684-q10sx1dm	302	38	of	of	IN
cord-015684-q10sx1dm	302	39	Ethiopians	Ethiopians	NNPS
cord-015684-q10sx1dm	302	40	.	.	.
cord-015684-q10sx1dm	303	1	The	the	DT
cord-015684-q10sx1dm	303	2	CYP2D6	CYP2D6	NNPS
cord-015684-q10sx1dm	303	3	*	*	NFP
cord-015684-q10sx1dm	303	4	17	17	CD
cord-015684-q10sx1dm	303	5	variant	variant	NN
cord-015684-q10sx1dm	303	6	causes	cause	VBZ
cord-015684-q10sx1dm	303	7	Thr107Ile	Thr107Ile	NNP
cord-015684-q10sx1dm	303	8	and	and	CC
cord-015684-q10sx1dm	303	9	Arg296Cys	arg296cys	CD
cord-015684-q10sx1dm	303	10	substitutions	substitution	NNS
cord-015684-q10sx1dm	303	11	which	which	WDT
cord-015684-q10sx1dm	303	12	produce	produce	VBP
cord-015684-q10sx1dm	303	13	a	a	DT
cord-015684-q10sx1dm	303	14	reduced	reduce	VBN
cord-015684-q10sx1dm	303	15	affi	affi	FW
cord-015684-q10sx1dm	303	16	nity	nity	NN
cord-015684-q10sx1dm	303	17	for	for	IN
cord-015684-q10sx1dm	303	18	substrates	substrate	NNS
cord-015684-q10sx1dm	303	19	in	in	IN
cord-015684-q10sx1dm	303	20	51	51	CD
cord-015684-q10sx1dm	303	21	%	%	NN
cord-015684-q10sx1dm	303	22	of	of	IN
cord-015684-q10sx1dm	303	23	Asians	Asians	NNPS
cord-015684-q10sx1dm	303	24	,	,	,
cord-015684-q10sx1dm	303	25	6	6	CD
cord-015684-q10sx1dm	303	26	%	%	NN
cord-015684-q10sx1dm	303	27	of	of	IN
cord-015684-q10sx1dm	303	28	Africans	Africans	NNPS
cord-015684-q10sx1dm	303	29	,	,	,
cord-015684-q10sx1dm	303	30	and	and	CC
cord-015684-q10sx1dm	303	31	3	3	CD
cord-015684-q10sx1dm	303	32	-	-	SYM
cord-015684-q10sx1dm	303	33	9	9	CD
cord-015684-q10sx1dm	303	34	%	%	NN
cord-015684-q10sx1dm	303	35	of	of	IN
cord-015684-q10sx1dm	303	36	Ethiopians	Ethiopians	NNPS
cord-015684-q10sx1dm	303	37	,	,	,
cord-015684-q10sx1dm	303	38	and	and	CC
cord-015684-q10sx1dm	303	39	is	be	VBZ
cord-015684-q10sx1dm	303	40	practically	practically	RB
cord-015684-q10sx1dm	303	41	absent	absent	JJ
cord-015684-q10sx1dm	303	42	in	in	IN
cord-015684-q10sx1dm	303	43	Caucasians	Caucasians	NNPS
cord-015684-q10sx1dm	303	44	.	.	.
cord-015684-q10sx1dm	304	1	[	[	-LRB-
cord-015684-q10sx1dm	304	2	18	18	CD
cord-015684-q10sx1dm	304	3	]	]	-RRB-
cord-015684-q10sx1dm	304	4	[	[	-LRB-
cord-015684-q10sx1dm	304	5	19	19	CD
cord-015684-q10sx1dm	304	6	]	]	-RRB-
cord-015684-q10sx1dm	304	7	[	[	-LRB-
cord-015684-q10sx1dm	304	8	20	20	CD
cord-015684-q10sx1dm	304	9	]	]	-RRB-
cord-015684-q10sx1dm	304	10	86	86	CD
cord-015684-q10sx1dm	304	11	,	,	,
cord-015684-q10sx1dm	304	12	96	96	CD
cord-015684-q10sx1dm	304	13	,	,	,
cord-015684-q10sx1dm	304	14	102	102	CD
cord-015684-q10sx1dm	304	15	 	 	_SP
cord-015684-q10sx1dm	305	1	The	the	DT
cord-015684-q10sx1dm	305	2	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	305	3	enzyme	enzyme	NN
cord-015684-q10sx1dm	305	4	,	,	,
cord-015684-q10sx1dm	305	5	encoded	encode	VBN
cord-015684-q10sx1dm	305	6	by	by	IN
cord-015684-q10sx1dm	305	7	a	a	DT
cord-015684-q10sx1dm	305	8	gene	gene	NN
cord-015684-q10sx1dm	305	9	that	that	WDT
cord-015684-q10sx1dm	305	10	maps	map	VBZ
cord-015684-q10sx1dm	305	11	on	on	IN
cord-015684-q10sx1dm	305	12	22q13.1	22q13.1	CD
cord-015684-q10sx1dm	305	13	-	-	HYPH
cord-015684-q10sx1dm	305	14	13.2	13.2	CD
cord-015684-q10sx1dm	305	15	,	,	,
cord-015684-q10sx1dm	305	16	catalyses	catalyse	VBZ
cord-015684-q10sx1dm	305	17	the	the	DT
cord-015684-q10sx1dm	305	18	oxidative	oxidative	JJ
cord-015684-q10sx1dm	305	19	metabolism	metabolism	NN
cord-015684-q10sx1dm	305	20	of	of	IN
cord-015684-q10sx1dm	305	21	more	more	JJR
cord-015684-q10sx1dm	305	22	than	than	IN
cord-015684-q10sx1dm	305	23	100	100	CD
cord-015684-q10sx1dm	305	24	clinically	clinically	RB
cord-015684-q10sx1dm	305	25	important	important	JJ
cord-015684-q10sx1dm	305	26	and	and	CC
cord-015684-q10sx1dm	305	27	commonly	commonly	RB
cord-015684-q10sx1dm	305	28	prescribed	prescribe	VBN
cord-015684-q10sx1dm	305	29	drugs	drug	NNS
cord-015684-q10sx1dm	305	30	such	such	JJ
cord-015684-q10sx1dm	305	31	as	as	IN
cord-015684-q10sx1dm	305	32	cholinesterase	cholinesterase	NN
cord-015684-q10sx1dm	305	33	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	305	34	,	,	,
cord-015684-q10sx1dm	305	35	antidepressants	antidepressant	NNS
cord-015684-q10sx1dm	305	36	,	,	,
cord-015684-q10sx1dm	305	37	neuroleptics	neuroleptic	NNS
cord-015684-q10sx1dm	305	38	,	,	,
cord-015684-q10sx1dm	305	39	opioids	opioid	NNS
cord-015684-q10sx1dm	305	40	,	,	,
cord-015684-q10sx1dm	305	41	some	some	DT
cord-015684-q10sx1dm	305	42	β	β	NN
cord-015684-q10sx1dm	305	43	-	-	HYPH
cord-015684-q10sx1dm	305	44	blockers	blocker	NNS
cord-015684-q10sx1dm	305	45	,	,	,
cord-015684-q10sx1dm	305	46	class	class	NN
cord-015684-q10sx1dm	305	47	I	-PRON-	PRP
cord-015684-q10sx1dm	305	48	antiarrhythmics	antiarrhythmic	NNS
cord-015684-q10sx1dm	305	49	,	,	,
cord-015684-q10sx1dm	305	50	analgesics	analgesic	NNS
cord-015684-q10sx1dm	305	51	and	and	CC
cord-015684-q10sx1dm	305	52	many	many	JJ
cord-015684-q10sx1dm	305	53	other	other	JJ
cord-015684-q10sx1dm	305	54	drug	drug	NN
cord-015684-q10sx1dm	305	55	categories	category	NNS
cord-015684-q10sx1dm	305	56	,	,	,
cord-015684-q10sx1dm	305	57	acting	act	VBG
cord-015684-q10sx1dm	305	58	as	as	IN
cord-015684-q10sx1dm	305	59	substrates	substrate	NNS
cord-015684-q10sx1dm	305	60	,	,	,
cord-015684-q10sx1dm	305	61	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	305	62	or	or	CC
cord-015684-q10sx1dm	305	63	inducers	inducer	NNS
cord-015684-q10sx1dm	305	64	with	with	IN
cord-015684-q10sx1dm	305	65	which	which	WDT
cord-015684-q10sx1dm	305	66	most	most	JJS
cord-015684-q10sx1dm	305	67	psychotropics	psychotropic	NNS
cord-015684-q10sx1dm	305	68	may	may	MD
cord-015684-q10sx1dm	305	69	potentially	potentially	RB
cord-015684-q10sx1dm	305	70	interact	interact	VB
cord-015684-q10sx1dm	305	71	(	(	-LRB-
cord-015684-q10sx1dm	305	72	Table	table	NN
cord-015684-q10sx1dm	305	73	40	40	CD
cord-015684-q10sx1dm	305	74	.5	.5	CD
cord-015684-q10sx1dm	305	75	)	)	-RRB-
cord-015684-q10sx1dm	305	76	,	,	,
cord-015684-q10sx1dm	305	77	this	this	DT
cord-015684-q10sx1dm	305	78	leading	lead	VBG
cord-015684-q10sx1dm	305	79	to	to	IN
cord-015684-q10sx1dm	305	80	the	the	DT
cord-015684-q10sx1dm	305	81	outcome	outcome	NN
cord-015684-q10sx1dm	305	82	of	of	IN
cord-015684-q10sx1dm	305	83	ADRs	adr	NNS
cord-015684-q10sx1dm	305	84	.	.	.
cord-015684-q10sx1dm	306	1	[	[	-LRB-
cord-015684-q10sx1dm	306	2	18	18	CD
cord-015684-q10sx1dm	306	3	]	]	-RRB-
cord-015684-q10sx1dm	306	4	[	[	-LRB-
cord-015684-q10sx1dm	306	5	19	19	CD
cord-015684-q10sx1dm	306	6	]	]	-RRB-
cord-015684-q10sx1dm	306	7	[	[	-LRB-
cord-015684-q10sx1dm	306	8	20	20	CD
cord-015684-q10sx1dm	306	9	]	]	-RRB-
cord-015684-q10sx1dm	306	10	86	86	CD
cord-015684-q10sx1dm	306	11	,	,	,
cord-015684-q10sx1dm	306	12	96	96	CD
cord-015684-q10sx1dm	306	13	,	,	,
cord-015684-q10sx1dm	306	14	103	103	CD
cord-015684-q10sx1dm	307	1	The	the	DT
cord-015684-q10sx1dm	307	2	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	307	3	locus	locus	NN
cord-015684-q10sx1dm	307	4	is	be	VBZ
cord-015684-q10sx1dm	307	5	highly	highly	RB
cord-015684-q10sx1dm	307	6	polymorphic	polymorphic	JJ
cord-015684-q10sx1dm	307	7	,	,	,
cord-015684-q10sx1dm	307	8	with	with	IN
cord-015684-q10sx1dm	307	9	more	more	JJR
cord-015684-q10sx1dm	307	10	than	than	IN
cord-015684-q10sx1dm	307	11	100	100	CD
cord-015684-q10sx1dm	307	12	different	different	JJ
cord-015684-q10sx1dm	307	13	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	307	14	alleles	allele	NNS
cord-015684-q10sx1dm	307	15	identifi	identifi	VBN
cord-015684-q10sx1dm	307	16	ed	ed	NN
cord-015684-q10sx1dm	307	17	in	in	IN
cord-015684-q10sx1dm	307	18	the	the	DT
cord-015684-q10sx1dm	307	19	general	general	JJ
cord-015684-q10sx1dm	307	20	population	population	NN
cord-015684-q10sx1dm	307	21	showing	show	VBG
cord-015684-q10sx1dm	307	22	defi	defi	NNP
cord-015684-q10sx1dm	307	23	cient	cient	NNP
cord-015684-q10sx1dm	307	24	(	(	-LRB-
cord-015684-q10sx1dm	307	25	poor	poor	JJ
cord-015684-q10sx1dm	307	26	metabolizers	metabolizer	NNS
cord-015684-q10sx1dm	307	27	,	,	,
cord-015684-q10sx1dm	307	28	PM	PM	NNP
cord-015684-q10sx1dm	307	29	)	)	-RRB-
cord-015684-q10sx1dm	307	30	,	,	,
cord-015684-q10sx1dm	307	31	normal	normal	JJ
cord-015684-q10sx1dm	307	32	(	(	-LRB-
cord-015684-q10sx1dm	307	33	extensive	extensive	JJ
cord-015684-q10sx1dm	307	34	metabolizers	metabolizer	NNS
cord-015684-q10sx1dm	307	35	,	,	,
cord-015684-q10sx1dm	307	36	EM	EM	NNP
cord-015684-q10sx1dm	307	37	)	)	-RRB-
cord-015684-q10sx1dm	307	38	or	or	CC
cord-015684-q10sx1dm	307	39	increased	increase	VBN
cord-015684-q10sx1dm	307	40	enzymatic	enzymatic	JJ
cord-015684-q10sx1dm	307	41	activity	activity	NN
cord-015684-q10sx1dm	307	42	(	(	-LRB-
cord-015684-q10sx1dm	307	43	ultra	ultra	JJ
cord-015684-q10sx1dm	307	44	-	-	JJ
cord-015684-q10sx1dm	307	45	rapid	rapid	JJ
cord-015684-q10sx1dm	307	46	metabolizers	metabolizer	NNS
cord-015684-q10sx1dm	307	47	,	,	,
cord-015684-q10sx1dm	307	48	UM	um	UH
cord-015684-q10sx1dm	307	49	)	)	-RRB-
cord-015684-q10sx1dm	307	50	.	.	.
cord-015684-q10sx1dm	308	1	100,104	100,104	CD
cord-015684-q10sx1dm	308	2	Most	Most	JJS
cord-015684-q10sx1dm	308	3	individuals	individual	NNS
cord-015684-q10sx1dm	308	4	(	(	-LRB-
cord-015684-q10sx1dm	308	5	>	>	NFP
cord-015684-q10sx1dm	308	6	80	80	CD
cord-015684-q10sx1dm	308	7	%	%	NN
cord-015684-q10sx1dm	308	8	)	)	-RRB-
cord-015684-q10sx1dm	308	9	are	be	VBP
cord-015684-q10sx1dm	308	10	EMs	em	NNS
cord-015684-q10sx1dm	308	11	;	;	:
cord-015684-q10sx1dm	308	12	however	however	RB
cord-015684-q10sx1dm	308	13	,	,	,
cord-015684-q10sx1dm	308	14	remarkable	remarkable	JJ
cord-015684-q10sx1dm	308	15	interethnic	interethnic	JJ
cord-015684-q10sx1dm	308	16	differences	difference	NNS
cord-015684-q10sx1dm	308	17	exist	exist	VBP
cord-015684-q10sx1dm	308	18	in	in	IN
cord-015684-q10sx1dm	308	19	the	the	DT
cord-015684-q10sx1dm	308	20	frequency	frequency	NN
cord-015684-q10sx1dm	308	21	of	of	IN
cord-015684-q10sx1dm	308	22	the	the	DT
cord-015684-q10sx1dm	308	23	PM	PM	NNP
cord-015684-q10sx1dm	308	24	and	and	CC
cord-015684-q10sx1dm	308	25	UM	UM	NNP
cord-015684-q10sx1dm	308	26	phenotypes	phenotype	NNS
cord-015684-q10sx1dm	308	27	among	among	IN
cord-015684-q10sx1dm	308	28	different	different	JJ
cord-015684-q10sx1dm	308	29	societies	society	NNS
cord-015684-q10sx1dm	308	30	all	all	RB
cord-015684-q10sx1dm	308	31	over	over	IN
cord-015684-q10sx1dm	308	32	the	the	DT
cord-015684-q10sx1dm	308	33	world	world	NN
cord-015684-q10sx1dm	308	34	.	.	.
cord-015684-q10sx1dm	309	1	[	[	-LRB-
cord-015684-q10sx1dm	309	2	18	18	CD
cord-015684-q10sx1dm	309	3	]	]	-RRB-
cord-015684-q10sx1dm	309	4	[	[	-LRB-
cord-015684-q10sx1dm	309	5	19	19	CD
cord-015684-q10sx1dm	309	6	]	]	-RRB-
cord-015684-q10sx1dm	309	7	[	[	-LRB-
cord-015684-q10sx1dm	309	8	20	20	CD
cord-015684-q10sx1dm	309	9	]	]	-RRB-
cord-015684-q10sx1dm	309	10	89	89	CD
cord-015684-q10sx1dm	309	11	,	,	,
cord-015684-q10sx1dm	309	12	[	[	-LRB-
cord-015684-q10sx1dm	309	13	91	91	CD
cord-015684-q10sx1dm	309	14	]	]	-RRB-
cord-015684-q10sx1dm	309	15	[	[	-LRB-
cord-015684-q10sx1dm	309	16	92	92	CD
cord-015684-q10sx1dm	309	17	]	]	-RRB-
cord-015684-q10sx1dm	310	1	[	[	-LRB-
cord-015684-q10sx1dm	310	2	93	93	CD
cord-015684-q10sx1dm	310	3	]	]	-RRB-
cord-015684-q10sx1dm	311	1	[	[	-LRB-
cord-015684-q10sx1dm	311	2	94	94	CD
cord-015684-q10sx1dm	311	3	]	]	-RRB-
cord-015684-q10sx1dm	311	4	102	102	CD
cord-015684-q10sx1dm	312	1	On	on	IN
cord-015684-q10sx1dm	312	2	the	the	DT
cord-015684-q10sx1dm	312	3	average	average	NN
cord-015684-q10sx1dm	312	4	,	,	,
cord-015684-q10sx1dm	312	5	approximately	approximately	RB
cord-015684-q10sx1dm	312	6	6.28	6.28	CD
cord-015684-q10sx1dm	312	7	%	%	NN
cord-015684-q10sx1dm	312	8	of	of	IN
cord-015684-q10sx1dm	312	9	the	the	DT
cord-015684-q10sx1dm	312	10	world	world	NN
cord-015684-q10sx1dm	312	11	population	population	NN
cord-015684-q10sx1dm	312	12	belongs	belong	VBZ
cord-015684-q10sx1dm	312	13	to	to	IN
cord-015684-q10sx1dm	312	14	the	the	DT
cord-015684-q10sx1dm	312	15	PM	PM	NNP
cord-015684-q10sx1dm	312	16	category	category	NN
cord-015684-q10sx1dm	312	17	.	.	.
cord-015684-q10sx1dm	313	1	Europeans	Europeans	NNPS
cord-015684-q10sx1dm	313	2	(	(	-LRB-
cord-015684-q10sx1dm	313	3	7.86	7.86	CD
cord-015684-q10sx1dm	313	4	%	%	NN
cord-015684-q10sx1dm	313	5	)	)	-RRB-
cord-015684-q10sx1dm	313	6	,	,	,
cord-015684-q10sx1dm	313	7	Polynesians	Polynesians	NNPS
cord-015684-q10sx1dm	313	8	(	(	-LRB-
cord-015684-q10sx1dm	313	9	7.27	7.27	CD
cord-015684-q10sx1dm	313	10	%	%	NN
cord-015684-q10sx1dm	313	11	)	)	-RRB-
cord-015684-q10sx1dm	313	12	,	,	,
cord-015684-q10sx1dm	313	13	and	and	CC
cord-015684-q10sx1dm	313	14	Africans	Africans	NNPS
cord-015684-q10sx1dm	313	15	(	(	-LRB-
cord-015684-q10sx1dm	313	16	6.73	6.73	CD
cord-015684-q10sx1dm	313	17	%	%	NN
cord-015684-q10sx1dm	313	18	)	)	-RRB-
cord-015684-q10sx1dm	313	19	exhibit	exhibit	VBP
cord-015684-q10sx1dm	313	20	the	the	DT
cord-015684-q10sx1dm	313	21	highest	high	JJS
cord-015684-q10sx1dm	313	22	rate	rate	NN
cord-015684-q10sx1dm	313	23	of	of	IN
cord-015684-q10sx1dm	313	24	PMs	pm	NNS
cord-015684-q10sx1dm	313	25	,	,	,
cord-015684-q10sx1dm	313	26	whereas	whereas	IN
cord-015684-q10sx1dm	313	27	Orientals	Orientals	NNPS
cord-015684-q10sx1dm	313	28	(	(	-LRB-
cord-015684-q10sx1dm	313	29	0.94	0.94	CD
cord-015684-q10sx1dm	313	30	%	%	NN
cord-015684-q10sx1dm	313	31	)	)	-RRB-
cord-015684-q10sx1dm	313	32	show	show	VBP
cord-015684-q10sx1dm	313	33	the	the	DT
cord-015684-q10sx1dm	313	34	lowest	low	JJS
cord-015684-q10sx1dm	313	35	rate	rate	NN
cord-015684-q10sx1dm	313	36	.	.	.
cord-015684-q10sx1dm	314	1	The	the	DT
cord-015684-q10sx1dm	314	2	frequency	frequency	NN
cord-015684-q10sx1dm	314	3	of	of	IN
cord-015684-q10sx1dm	314	4	PMs	pm	NNS
cord-015684-q10sx1dm	314	5	among	among	IN
cord-015684-q10sx1dm	314	6	Middle	middle	JJ
cord-015684-q10sx1dm	314	7	Eastern	eastern	JJ
cord-015684-q10sx1dm	314	8	populations	population	NNS
cord-015684-q10sx1dm	314	9	,	,	,
cord-015684-q10sx1dm	314	10	Asians	Asians	NNPS
cord-015684-q10sx1dm	314	11	,	,	,
cord-015684-q10sx1dm	314	12	and	and	CC
cord-015684-q10sx1dm	314	13	Americans	Americans	NNPS
cord-015684-q10sx1dm	314	14	is	be	VBZ
cord-015684-q10sx1dm	314	15	in	in	IN
cord-015684-q10sx1dm	314	16	the	the	DT
cord-015684-q10sx1dm	314	17	range	range	NN
cord-015684-q10sx1dm	314	18	of	of	IN
cord-015684-q10sx1dm	314	19	2	2	CD
cord-015684-q10sx1dm	314	20	-	-	SYM
cord-015684-q10sx1dm	314	21	3	3	CD
cord-015684-q10sx1dm	314	22	%	%	NN
cord-015684-q10sx1dm	314	23	.	.	.
cord-015684-q10sx1dm	315	1	[	[	-LRB-
cord-015684-q10sx1dm	315	2	16	16	CD
cord-015684-q10sx1dm	315	3	]	]	-RRB-
cord-015684-q10sx1dm	315	4	[	[	-LRB-
cord-015684-q10sx1dm	315	5	17	17	CD
cord-015684-q10sx1dm	315	6	]	]	-RRB-
cord-015684-q10sx1dm	315	7	[	[	-LRB-
cord-015684-q10sx1dm	315	8	18	18	CD
cord-015684-q10sx1dm	315	9	]	]	-RRB-
cord-015684-q10sx1dm	315	10	[	[	-LRB-
cord-015684-q10sx1dm	315	11	19	19	CD
cord-015684-q10sx1dm	315	12	]	]	-RRB-
cord-015684-q10sx1dm	315	13	[	[	-LRB-
cord-015684-q10sx1dm	315	14	20	20	CD
cord-015684-q10sx1dm	315	15	]	]	-RRB-
cord-015684-q10sx1dm	316	1	94	94	CD
cord-015684-q10sx1dm	316	2	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	316	3	gene	gene	NN
cord-015684-q10sx1dm	316	4	duplications	duplication	NNS
cord-015684-q10sx1dm	316	5	are	be	VBP
cord-015684-q10sx1dm	316	6	relatively	relatively	RB
cord-015684-q10sx1dm	316	7	infrequent	infrequent	JJ
cord-015684-q10sx1dm	316	8	among	among	IN
cord-015684-q10sx1dm	316	9	Northern	northern	JJ
cord-015684-q10sx1dm	316	10	Europeans	Europeans	NNPS
cord-015684-q10sx1dm	316	11	,	,	,
cord-015684-q10sx1dm	316	12	but	but	CC
cord-015684-q10sx1dm	316	13	in	in	IN
cord-015684-q10sx1dm	316	14	East	East	NNP
cord-015684-q10sx1dm	316	15	Africa	Africa	NNP
cord-015684-q10sx1dm	316	16	the	the	DT
cord-015684-q10sx1dm	316	17	frequency	frequency	NN
cord-015684-q10sx1dm	316	18	of	of	IN
cord-015684-q10sx1dm	316	19	alleles	allele	NNS
cord-015684-q10sx1dm	316	20	with	with	IN
cord-015684-q10sx1dm	316	21	duplication	duplication	NN
cord-015684-q10sx1dm	316	22	of	of	IN
cord-015684-q10sx1dm	316	23	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	316	24	is	be	VBZ
cord-015684-q10sx1dm	316	25	as	as	RB
cord-015684-q10sx1dm	316	26	high	high	JJ
cord-015684-q10sx1dm	316	27	as	as	IN
cord-015684-q10sx1dm	316	28	29	29	CD
cord-015684-q10sx1dm	316	29	%	%	NN
cord-015684-q10sx1dm	316	30	.	.	.
cord-015684-q10sx1dm	317	1	73	73	CD
cord-015684-q10sx1dm	318	1	The	the	DT
cord-015684-q10sx1dm	318	2	most	most	RBS
cord-015684-q10sx1dm	318	3	frequent	frequent	JJ
cord-015684-q10sx1dm	318	4	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	318	5	alleles	allele	NNS
cord-015684-q10sx1dm	318	6	in	in	IN
cord-015684-q10sx1dm	318	7	the	the	DT
cord-015684-q10sx1dm	318	8	European	european	JJ
cord-015684-q10sx1dm	318	9	population	population	NN
cord-015684-q10sx1dm	318	10	are	be	VBP
cord-015684-q10sx1dm	318	11	the	the	DT
cord-015684-q10sx1dm	318	12	following	follow	VBG
cord-015684-q10sx1dm	318	13	:	:	:
cord-015684-q10sx1dm	318	14	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	318	15	*	*	NFP
cord-015684-q10sx1dm	318	16	1	1	CD
cord-015684-q10sx1dm	318	17	(	(	-LRB-
cord-015684-q10sx1dm	318	18	wild	wild	JJ
cord-015684-q10sx1dm	318	19	-	-	HYPH
cord-015684-q10sx1dm	318	20	type	type	NN
cord-015684-q10sx1dm	318	21	)	)	-RRB-
cord-015684-q10sx1dm	318	22	(	(	-LRB-
cord-015684-q10sx1dm	318	23	normal	normal	JJ
cord-015684-q10sx1dm	318	24	)	)	-RRB-
cord-015684-q10sx1dm	318	25	,	,	,
cord-015684-q10sx1dm	318	26	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	318	27	*	*	NFP
cord-015684-q10sx1dm	318	28	2	2	CD
cord-015684-q10sx1dm	318	29	(	(	-LRB-
cord-015684-q10sx1dm	318	30	2850C	2850c	CD
cord-015684-q10sx1dm	319	1	>	>	XX
cord-015684-q10sx1dm	320	1	T)(normal	T)(normal	NNP
cord-015684-q10sx1dm	320	2	)	)	-RRB-
cord-015684-q10sx1dm	320	3	,	,	,
cord-015684-q10sx1dm	320	4	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	320	5	*	*	NFP
cord-015684-q10sx1dm	320	6	3	3	CD
cord-015684-q10sx1dm	320	7	(	(	-LRB-
cord-015684-q10sx1dm	320	8	2549A	2549a	UH
cord-015684-q10sx1dm	320	9	>	>	XX
cord-015684-q10sx1dm	320	10	del)(inactive	del)(inactive	NN
cord-015684-q10sx1dm	320	11	)	)	-RRB-
cord-015684-q10sx1dm	320	12	,	,	,
cord-015684-q10sx1dm	320	13	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	320	14	*	*	NFP
cord-015684-q10sx1dm	320	15	4	4	CD
cord-015684-q10sx1dm	320	16	(	(	-LRB-
cord-015684-q10sx1dm	320	17	1846	1846	CD
cord-015684-q10sx1dm	320	18	G	g	NN
cord-015684-q10sx1dm	320	19	>	>	XX
cord-015684-q10sx1dm	320	20	A)(inactive	A)(inactive	NNP
cord-015684-q10sx1dm	320	21	)	)	-RRB-
cord-015684-q10sx1dm	320	22	,	,	,
cord-015684-q10sx1dm	320	23	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	320	24	*	*	NFP
cord-015684-q10sx1dm	320	25	5	5	CD
cord-015684-q10sx1dm	320	26	(	(	-LRB-
cord-015684-q10sx1dm	320	27	gene	gene	NN
cord-015684-q10sx1dm	320	28	deletion)(inactive	deletion)(inactive	NNP
cord-015684-q10sx1dm	320	29	)	)	-RRB-
cord-015684-q10sx1dm	320	30	,	,	,
cord-015684-q10sx1dm	320	31	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	320	32	*	*	NFP
cord-015684-q10sx1dm	320	33	6	6	CD
cord-015684-q10sx1dm	320	34	(	(	-LRB-
cord-015684-q10sx1dm	320	35	1707	1707	CD
cord-015684-q10sx1dm	320	36	T	t	NN
cord-015684-q10sx1dm	320	37	>	>	XX
cord-015684-q10sx1dm	320	38	del)(inactive	del)(inactive	NN
cord-015684-q10sx1dm	320	39	)	)	-RRB-
cord-015684-q10sx1dm	320	40	,	,	,
cord-015684-q10sx1dm	320	41	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	320	42	*	*	NFP
cord-015684-q10sx1dm	320	43	7	7	CD
cord-015684-q10sx1dm	320	44	(	(	-LRB-
cord-015684-q10sx1dm	320	45	2935A	2935a	CD
cord-015684-q10sx1dm	321	1	>	>	XX
cord-015684-q10sx1dm	321	2	C)(inac	c)(inac	JJ
cord-015684-q10sx1dm	321	3	-	-	HYPH
cord-015684-q10sx1dm	321	4	tive	tive	JJ
cord-015684-q10sx1dm	321	5	)	)	-RRB-
cord-015684-q10sx1dm	321	6	,	,	,
cord-015684-q10sx1dm	321	7	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	321	8	*	*	NFP
cord-015684-q10sx1dm	321	9	8	8	CD
cord-015684-q10sx1dm	321	10	(	(	-LRB-
cord-015684-q10sx1dm	321	11	1758	1758	CD
cord-015684-q10sx1dm	321	12	G	g	NN
cord-015684-q10sx1dm	322	1	>	>	XX
cord-015684-q10sx1dm	323	1	T)(inactive	T)(inactive	NNP
cord-015684-q10sx1dm	323	2	)	)	-RRB-
cord-015684-q10sx1dm	323	3	,	,	,
cord-015684-q10sx1dm	323	4	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	323	5	*	*	NFP
cord-015684-q10sx1dm	323	6	9	9	CD
cord-015684-q10sx1dm	323	7	(	(	-LRB-
cord-015684-q10sx1dm	323	8	2613	2613	CD
cord-015684-q10sx1dm	323	9	-	-	SYM
cord-015684-q10sx1dm	323	10	2615	2615	CD
cord-015684-q10sx1dm	324	1	delAGA)(partially	delaga)(partially	RB
cord-015684-q10sx1dm	324	2	active	active	JJ
cord-015684-q10sx1dm	324	3	)	)	-RRB-
cord-015684-q10sx1dm	324	4	,	,	,
cord-015684-q10sx1dm	324	5	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	324	6	*	*	NFP
cord-015684-q10sx1dm	324	7	10	10	CD
cord-015684-q10sx1dm	324	8	(	(	-LRB-
cord-015684-q10sx1dm	324	9	100C	100C	.
cord-015684-q10sx1dm	325	1	>	>	XX
cord-015684-q10sx1dm	326	1	T)(partially	t)(partially	RB
cord-015684-q10sx1dm	326	2	active	active	JJ
cord-015684-q10sx1dm	326	3	)	)	-RRB-
cord-015684-q10sx1dm	326	4	,	,	,
cord-015684-q10sx1dm	326	5	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	326	6	*	*	NFP
cord-015684-q10sx1dm	326	7	11	11	CD
cord-015684-q10sx1dm	326	8	(	(	-LRB-
cord-015684-q10sx1dm	326	9	883	883	CD
cord-015684-q10sx1dm	326	10	G	g	NN
cord-015684-q10sx1dm	326	11	>	>	XX
cord-015684-q10sx1dm	326	12	C	c	NN
cord-015684-q10sx1dm	326	13	)	)	-RRB-
cord-015684-q10sx1dm	326	14	(	(	-LRB-
cord-015684-q10sx1dm	326	15	inactive	inactive	JJ
cord-015684-q10sx1dm	326	16	)	)	-RRB-
cord-015684-q10sx1dm	326	17	,	,	,
cord-015684-q10sx1dm	326	18	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	326	19	*	*	NFP
cord-015684-q10sx1dm	326	20	12	12	CD
cord-015684-q10sx1dm	326	21	(	(	-LRB-
cord-015684-q10sx1dm	326	22	124	124	CD
cord-015684-q10sx1dm	326	23	G	g	NN
cord-015684-q10sx1dm	326	24	>	>	XX
cord-015684-q10sx1dm	326	25	A)(inactive	A)(inactive	NNP
cord-015684-q10sx1dm	326	26	)	)	-RRB-
cord-015684-q10sx1dm	326	27	,	,	,
cord-015684-q10sx1dm	326	28	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	326	29	*	*	NFP
cord-015684-q10sx1dm	326	30	17	17	CD
cord-015684-q10sx1dm	326	31	(	(	-LRB-
cord-015684-q10sx1dm	326	32	1023C	1023C	NNP
cord-015684-q10sx1dm	326	33	>	>	XX
cord-015684-q10sx1dm	327	1	T)(partially	t)(partially	RB
cord-015684-q10sx1dm	327	2	active	active	JJ
cord-015684-q10sx1dm	327	3	)	)	-RRB-
cord-015684-q10sx1dm	327	4	,	,	,
cord-015684-q10sx1dm	327	5	and	and	CC
cord-015684-q10sx1dm	327	6	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	327	7	gene	gene	NN
cord-015684-q10sx1dm	327	8	duplications	duplication	NNS
cord-015684-q10sx1dm	327	9	(	(	-LRB-
cord-015684-q10sx1dm	327	10	with	with	IN
cord-015684-q10sx1dm	327	11	increased	increase	VBN
cord-015684-q10sx1dm	327	12	or	or	CC
cord-015684-q10sx1dm	327	13	decreased	decrease	VBN
cord-015684-q10sx1dm	327	14	enzymatic	enzymatic	JJ
cord-015684-q10sx1dm	327	15	activity	activity	NN
cord-015684-q10sx1dm	327	16	depending	depend	VBG
cord-015684-q10sx1dm	327	17	upon	upon	IN
cord-015684-q10sx1dm	327	18	the	the	DT
cord-015684-q10sx1dm	327	19	alleles	allele	NNS
cord-015684-q10sx1dm	327	20	involved	involve	VBN
cord-015684-q10sx1dm	327	21	)	)	-RRB-
cord-015684-q10sx1dm	327	22	.	.	.
cord-015684-q10sx1dm	328	1	[	[	-LRB-
cord-015684-q10sx1dm	328	2	16	16	CD
cord-015684-q10sx1dm	328	3	]	]	-RRB-
cord-015684-q10sx1dm	328	4	[	[	-LRB-
cord-015684-q10sx1dm	328	5	17	17	CD
cord-015684-q10sx1dm	328	6	]	]	-RRB-
cord-015684-q10sx1dm	328	7	[	[	-LRB-
cord-015684-q10sx1dm	328	8	18	18	CD
cord-015684-q10sx1dm	328	9	]	]	-RRB-
cord-015684-q10sx1dm	328	10	[	[	-LRB-
cord-015684-q10sx1dm	328	11	19	19	CD
cord-015684-q10sx1dm	328	12	]	]	-RRB-
cord-015684-q10sx1dm	329	1	[	[	-LRB-
cord-015684-q10sx1dm	329	2	20	20	CD
cord-015684-q10sx1dm	329	3	]	]	-RRB-
cord-015684-q10sx1dm	329	4	[	[	-LRB-
cord-015684-q10sx1dm	329	5	104	104	CD
cord-015684-q10sx1dm	329	6	]	]	-RRB-
cord-015684-q10sx1dm	329	7	[	[	-LRB-
cord-015684-q10sx1dm	329	8	105	105	CD
cord-015684-q10sx1dm	329	9	]	]	-RRB-
cord-015684-q10sx1dm	329	10	[	[	-LRB-
cord-015684-q10sx1dm	329	11	106	106	CD
cord-015684-q10sx1dm	329	12	]	]	-RRB-
cord-015684-q10sx1dm	330	1	In	in	IN
cord-015684-q10sx1dm	330	2	the	the	DT
cord-015684-q10sx1dm	330	3	Spanish	spanish	JJ
cord-015684-q10sx1dm	330	4	population	population	NN
cord-015684-q10sx1dm	330	5	,	,	,
cord-015684-q10sx1dm	330	6	where	where	WRB
cord-015684-q10sx1dm	330	7	the	the	DT
cord-015684-q10sx1dm	330	8	mixture	mixture	NN
cord-015684-q10sx1dm	330	9	of	of	IN
cord-015684-q10sx1dm	330	10	ancestral	ancestral	JJ
cord-015684-q10sx1dm	330	11	cultures	culture	NNS
cord-015684-q10sx1dm	330	12	has	have	VBZ
cord-015684-q10sx1dm	330	13	occurred	occur	VBN
cord-015684-q10sx1dm	330	14	for	for	IN
cord-015684-q10sx1dm	330	15	centuries	century	NNS
cord-015684-q10sx1dm	330	16	,	,	,
cord-015684-q10sx1dm	330	17	the	the	DT
cord-015684-q10sx1dm	330	18	distribution	distribution	NN
cord-015684-q10sx1dm	330	19	of	of	IN
cord-015684-q10sx1dm	330	20	the	the	DT
cord-015684-q10sx1dm	330	21	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	330	22	genotypes	genotype	NNS
cord-015684-q10sx1dm	330	23	differentiates	differentiate	VBZ
cord-015684-q10sx1dm	330	24	4	4	CD
cord-015684-q10sx1dm	330	25	major	major	JJ
cord-015684-q10sx1dm	330	26	categories	category	NNS
cord-015684-q10sx1dm	330	27	of	of	IN
cord-015684-q10sx1dm	330	28	CYP2D6-related	cyp2d6-related	JJ
cord-015684-q10sx1dm	330	29	metabolizer	metabolizer	NN
cord-015684-q10sx1dm	330	30	types	type	NNS
cord-015684-q10sx1dm	330	31	:	:	:
cord-015684-q10sx1dm	330	32	(	(	-LRB-
cord-015684-q10sx1dm	330	33	i	i	NN
cord-015684-q10sx1dm	330	34	)	)	-RRB-
cord-015684-q10sx1dm	330	35	Extensive	Extensive	NNP
cord-015684-q10sx1dm	330	36	Metabolizers	Metabolizers	NNPS
cord-015684-q10sx1dm	330	37	(	(	-LRB-
cord-015684-q10sx1dm	330	38	EM	EM	NNP
cord-015684-q10sx1dm	330	39	)	)	-RRB-
cord-015684-q10sx1dm	331	1	(	(	-LRB-
cord-015684-q10sx1dm	331	2	*	*	NFP
cord-015684-q10sx1dm	331	3	1/	1/	CD
cord-015684-q10sx1dm	331	4	*	*	SYM
cord-015684-q10sx1dm	331	5	1	1	CD
cord-015684-q10sx1dm	331	6	,	,	,
cord-015684-q10sx1dm	331	7	*	*	NFP
cord-015684-q10sx1dm	331	8	1/	1/	CD
cord-015684-q10sx1dm	331	9	*	*	NFP
cord-015684-q10sx1dm	331	10	10	10	CD
cord-015684-q10sx1dm	331	11	)	)	-RRB-
cord-015684-q10sx1dm	331	12	;	;	:
cord-015684-q10sx1dm	331	13	(	(	-LRB-
cord-015684-q10sx1dm	331	14	ii	ii	NN
cord-015684-q10sx1dm	331	15	)	)	-RRB-
cord-015684-q10sx1dm	331	16	Intermediate	Intermediate	NNP
cord-015684-q10sx1dm	331	17	Metabolizers	Metabolizers	NNPS
cord-015684-q10sx1dm	331	18	(	(	-LRB-
cord-015684-q10sx1dm	331	19	IM	IM	NNP
cord-015684-q10sx1dm	331	20	)	)	-RRB-
cord-015684-q10sx1dm	332	1	(	(	-LRB-
cord-015684-q10sx1dm	332	2	*	*	NFP
cord-015684-q10sx1dm	332	3	1/	1/	CD
cord-015684-q10sx1dm	332	4	*	*	NFP
cord-015684-q10sx1dm	332	5	3	3	CD
cord-015684-q10sx1dm	332	6	,	,	,
cord-015684-q10sx1dm	332	7	*	*	NFP
cord-015684-q10sx1dm	332	8	1/	1/	CD
cord-015684-q10sx1dm	332	9	*	*	NFP
cord-015684-q10sx1dm	332	10	4	4	CD
cord-015684-q10sx1dm	332	11	,	,	,
cord-015684-q10sx1dm	332	12	*	*	NFP
cord-015684-q10sx1dm	332	13	1/	1/	CD
cord-015684-q10sx1dm	332	14	*	*	NFP
cord-015684-q10sx1dm	332	15	5	5	CD
cord-015684-q10sx1dm	332	16	,	,	,
cord-015684-q10sx1dm	332	17	*	*	NFP
cord-015684-q10sx1dm	332	18	1/	1/	CD
cord-015684-q10sx1dm	332	19	*	*	NFP
cord-015684-q10sx1dm	332	20	6	6	CD
cord-015684-q10sx1dm	332	21	,	,	,
cord-015684-q10sx1dm	332	22	*	*	NFP
cord-015684-q10sx1dm	332	23	1/	1/	CD
cord-015684-q10sx1dm	332	24	*	*	SYM
cord-015684-q10sx1dm	332	25	7	7	CD
cord-015684-q10sx1dm	332	26	,	,	,
cord-015684-q10sx1dm	333	1	*	*	NFP
cord-015684-q10sx1dm	333	2	10/	10/	LS
cord-015684-q10sx1dm	333	3	*	*	NFP
cord-015684-q10sx1dm	333	4	10	10	CD
cord-015684-q10sx1dm	333	5	,	,	,
cord-015684-q10sx1dm	334	1	*	*	NFP
cord-015684-q10sx1dm	334	2	4/	4/	CD
cord-015684-q10sx1dm	334	3	*	*	NFP
cord-015684-q10sx1dm	334	4	10	10	CD
cord-015684-q10sx1dm	334	5	,	,	,
cord-015684-q10sx1dm	335	1	*	*	NFP
cord-015684-q10sx1dm	335	2	6/	6/	CD
cord-015684-q10sx1dm	335	3	*	*	NFP
cord-015684-q10sx1dm	335	4	10	10	CD
cord-015684-q10sx1dm	335	5	,	,	,
cord-015684-q10sx1dm	335	6	*	*	NFP
cord-015684-q10sx1dm	335	7	7/	7/	CD
cord-015684-q10sx1dm	335	8	*	*	NFP
cord-015684-q10sx1dm	335	9	10	10	CD
cord-015684-q10sx1dm	335	10	)	)	-RRB-
cord-015684-q10sx1dm	335	11	;	;	:
cord-015684-q10sx1dm	335	12	(	(	-LRB-
cord-015684-q10sx1dm	335	13	iii	iii	NN
cord-015684-q10sx1dm	335	14	)	)	-RRB-
cord-015684-q10sx1dm	336	1	Poor	Poor	NNP
cord-015684-q10sx1dm	336	2	Metabolizers	Metabolizers	NNPS
cord-015684-q10sx1dm	336	3	(	(	-LRB-
cord-015684-q10sx1dm	336	4	PM	pm	NN
cord-015684-q10sx1dm	336	5	)	)	-RRB-
cord-015684-q10sx1dm	337	1	(	(	-LRB-
cord-015684-q10sx1dm	337	2	*	*	NFP
cord-015684-q10sx1dm	337	3	4/	4/	CD
cord-015684-q10sx1dm	337	4	*	*	NFP
cord-015684-q10sx1dm	337	5	4	4	CD
cord-015684-q10sx1dm	337	6	,	,	,
cord-015684-q10sx1dm	338	1	*	*	NFP
cord-015684-q10sx1dm	338	2	5/	5/	CD
cord-015684-q10sx1dm	338	3	*	*	NFP
cord-015684-q10sx1dm	338	4	5	5	CD
cord-015684-q10sx1dm	338	5	)	)	-RRB-
cord-015684-q10sx1dm	338	6	;	;	:
cord-015684-q10sx1dm	339	1	and	and	CC
cord-015684-q10sx1dm	339	2	(	(	-LRB-
cord-015684-q10sx1dm	339	3	iv	iv	LS
cord-015684-q10sx1dm	339	4	)	)	-RRB-
cord-015684-q10sx1dm	339	5	Ultra	ultra	JJ
cord-015684-q10sx1dm	339	6	-	-	JJ
cord-015684-q10sx1dm	339	7	rapid	rapid	JJ
cord-015684-q10sx1dm	339	8	Metabolizers	Metabolizers	NNPS
cord-015684-q10sx1dm	339	9	(	(	-LRB-
cord-015684-q10sx1dm	339	10	UM	um	UH
cord-015684-q10sx1dm	339	11	)	)	-RRB-
cord-015684-q10sx1dm	339	12	(	(	-LRB-
cord-015684-q10sx1dm	339	13	*	*	NFP
cord-015684-q10sx1dm	339	14	1xN/	1xn/	CD
cord-015684-q10sx1dm	339	15	*	*	SYM
cord-015684-q10sx1dm	339	16	1	1	CD
cord-015684-q10sx1dm	339	17	,	,	,
cord-015684-q10sx1dm	339	18	*	*	NFP
cord-015684-q10sx1dm	340	1	1xN/	1xn/	CD
cord-015684-q10sx1dm	340	2	*	*	NFP
cord-015684-q10sx1dm	340	3	4	4	CD
cord-015684-q10sx1dm	340	4	,	,	,
cord-015684-q10sx1dm	340	5	Dupl	Dupl	NNP
cord-015684-q10sx1dm	340	6	)	)	-RRB-
cord-015684-q10sx1dm	340	7	.	.	.
cord-015684-q10sx1dm	341	1	In	in	IN
cord-015684-q10sx1dm	341	2	this	this	DT
cord-015684-q10sx1dm	341	3	sample	sample	NN
cord-015684-q10sx1dm	341	4	we	-PRON-	PRP
cord-015684-q10sx1dm	341	5	have	have	VBP
cord-015684-q10sx1dm	341	6	found	find	VBN
cord-015684-q10sx1dm	341	7	51.61	51.61	CD
cord-015684-q10sx1dm	341	8	%	%	NN
cord-015684-q10sx1dm	341	9	EMs	EMs	NNP
cord-015684-q10sx1dm	341	10	,	,	,
cord-015684-q10sx1dm	341	11	32.26	32.26	CD
cord-015684-q10sx1dm	341	12	%	%	NN
cord-015684-q10sx1dm	341	13	IMs	IMs	NNP
cord-015684-q10sx1dm	341	14	,	,	,
cord-015684-q10sx1dm	341	15	9.03	9.03	CD
cord-015684-q10sx1dm	341	16	%	%	NN
cord-015684-q10sx1dm	341	17	PMs	pm	NNS
cord-015684-q10sx1dm	341	18	,	,	,
cord-015684-q10sx1dm	341	19	and	and	CC
cord-015684-q10sx1dm	341	20	7.10	7.10	CD
cord-015684-q10sx1dm	341	21	%	%	NN
cord-015684-q10sx1dm	341	22	UMs	um	NNS
cord-015684-q10sx1dm	341	23	.	.	.
cord-015684-q10sx1dm	342	1	20	20	CD
cord-015684-q10sx1dm	342	2	,	,	,
cord-015684-q10sx1dm	342	3	[	[	-LRB-
cord-015684-q10sx1dm	342	4	74	74	CD
cord-015684-q10sx1dm	342	5	]	]	-RRB-
cord-015684-q10sx1dm	342	6	[	[	-LRB-
cord-015684-q10sx1dm	342	7	75	75	CD
cord-015684-q10sx1dm	342	8	]	]	-RRB-
cord-015684-q10sx1dm	342	9	[	[	-LRB-
cord-015684-q10sx1dm	342	10	76	76	CD
cord-015684-q10sx1dm	342	11	]	]	-RRB-
cord-015684-q10sx1dm	342	12	[	[	-LRB-
cord-015684-q10sx1dm	342	13	77	77	CD
cord-015684-q10sx1dm	342	14	]	]	-RRB-
cord-015684-q10sx1dm	343	1	The	the	DT
cord-015684-q10sx1dm	343	2	distribution	distribution	NN
cord-015684-q10sx1dm	343	3	of	of	IN
cord-015684-q10sx1dm	343	4	all	all	DT
cord-015684-q10sx1dm	343	5	major	major	JJ
cord-015684-q10sx1dm	343	6	genotypes	genotype	NNS
cord-015684-q10sx1dm	343	7	is	be	VBZ
cord-015684-q10sx1dm	343	8	the	the	DT
cord-015684-q10sx1dm	343	9	following	follow	VBG
cord-015684-q10sx1dm	343	10	:	:	:
cord-015684-q10sx1dm	344	1	*	*	NFP
cord-015684-q10sx1dm	344	2	1/	1/	CD
cord-015684-q10sx1dm	344	3	*	*	SYM
cord-015684-q10sx1dm	344	4	1	1	CD
cord-015684-q10sx1dm	344	5	,	,	,
cord-015684-q10sx1dm	344	6	47.10	47.10	CD
cord-015684-q10sx1dm	344	7	%	%	NN
cord-015684-q10sx1dm	344	8	;	;	.
cord-015684-q10sx1dm	345	1	*	*	NFP
cord-015684-q10sx1dm	345	2	1/	1/	CD
cord-015684-q10sx1dm	345	3	*	*	NFP
cord-015684-q10sx1dm	345	4	10	10	CD
cord-015684-q10sx1dm	345	5	,	,	,
cord-015684-q10sx1dm	345	6	4.52	4.52	CD
cord-015684-q10sx1dm	345	7	%	%	NN
cord-015684-q10sx1dm	345	8	;	;	:
cord-015684-q10sx1dm	345	9	*	*	NFP
cord-015684-q10sx1dm	345	10	1/	1/	CD
cord-015684-q10sx1dm	345	11	*	*	NFP
cord-015684-q10sx1dm	345	12	3	3	CD
cord-015684-q10sx1dm	345	13	,	,	,
cord-015684-q10sx1dm	345	14	1.95	1.95	CD
cord-015684-q10sx1dm	345	15	%	%	NN
cord-015684-q10sx1dm	345	16	;	;	,
cord-015684-q10sx1dm	345	17	*	*	NFP
cord-015684-q10sx1dm	345	18	1/	1/	CD
cord-015684-q10sx1dm	345	19	*	*	NFP
cord-015684-q10sx1dm	345	20	4	4	CD
cord-015684-q10sx1dm	345	21	,	,	,
cord-015684-q10sx1dm	345	22	17.42	17.42	CD
cord-015684-q10sx1dm	345	23	%	%	NN
cord-015684-q10sx1dm	345	24	;	;	.
cord-015684-q10sx1dm	346	1	*	*	NFP
cord-015684-q10sx1dm	346	2	1/	1/	CD
cord-015684-q10sx1dm	346	3	*	*	NFP
cord-015684-q10sx1dm	346	4	5	5	CD
cord-015684-q10sx1dm	346	5	,	,	,
cord-015684-q10sx1dm	346	6	3.87	3.87	CD
cord-015684-q10sx1dm	346	7	%	%	NN
cord-015684-q10sx1dm	346	8	;	;	:
cord-015684-q10sx1dm	346	9	*	*	NFP
cord-015684-q10sx1dm	346	10	1/	1/	CD
cord-015684-q10sx1dm	346	11	*	*	NFP
cord-015684-q10sx1dm	346	12	6	6	CD
cord-015684-q10sx1dm	346	13	,	,	,
cord-015684-q10sx1dm	346	14	2.58	2.58	CD
cord-015684-q10sx1dm	346	15	%	%	NN
cord-015684-q10sx1dm	346	16	;	;	.
cord-015684-q10sx1dm	347	1	*	*	NFP
cord-015684-q10sx1dm	347	2	1/	1/	CD
cord-015684-q10sx1dm	347	3	*	*	NFP
cord-015684-q10sx1dm	347	4	7	7	CD
cord-015684-q10sx1dm	347	5	,	,	,
cord-015684-q10sx1dm	347	6	0.65	0.65	CD
cord-015684-q10sx1dm	347	7	%	%	NN
cord-015684-q10sx1dm	347	8	;	;	:
cord-015684-q10sx1dm	347	9	*	*	NFP
cord-015684-q10sx1dm	347	10	10/	10/	LS
cord-015684-q10sx1dm	347	11	*	*	NFP
cord-015684-q10sx1dm	347	12	10	10	CD
cord-015684-q10sx1dm	347	13	,	,	,
cord-015684-q10sx1dm	347	14	1.30	1.30	CD
cord-015684-q10sx1dm	347	15	%	%	NN
cord-015684-q10sx1dm	347	16	;	;	,
cord-015684-q10sx1dm	347	17	*	*	NFP
cord-015684-q10sx1dm	347	18	4/	4/	CD
cord-015684-q10sx1dm	347	19	*	*	NFP
cord-015684-q10sx1dm	347	20	10	10	CD
cord-015684-q10sx1dm	347	21	,	,	,
cord-015684-q10sx1dm	347	22	3.23	3.23	CD
cord-015684-q10sx1dm	347	23	%	%	NN
cord-015684-q10sx1dm	347	24	;	;	.
cord-015684-q10sx1dm	348	1	*	*	NFP
cord-015684-q10sx1dm	348	2	6/	6/	CD
cord-015684-q10sx1dm	348	3	*	*	NFP
cord-015684-q10sx1dm	348	4	10	10	CD
cord-015684-q10sx1dm	348	5	,	,	,
cord-015684-q10sx1dm	348	6	0.65	0.65	CD
cord-015684-q10sx1dm	348	7	%	%	NN
cord-015684-q10sx1dm	348	8	;	;	.
cord-015684-q10sx1dm	349	1	*	*	NFP
cord-015684-q10sx1dm	349	2	7/	7/	CD
cord-015684-q10sx1dm	349	3	*	*	NFP
cord-015684-q10sx1dm	349	4	10	10	CD
cord-015684-q10sx1dm	349	5	,	,	,
cord-015684-q10sx1dm	349	6	0.65	0.65	CD
cord-015684-q10sx1dm	349	7	%	%	NN
cord-015684-q10sx1dm	349	8	;	;	,
cord-015684-q10sx1dm	349	9	*	*	NFP
cord-015684-q10sx1dm	349	10	4/	4/	CD
cord-015684-q10sx1dm	349	11	*	*	NFP
cord-015684-q10sx1dm	349	12	4	4	CD
cord-015684-q10sx1dm	349	13	,	,	,
cord-015684-q10sx1dm	349	14	8.37	8.37	CD
cord-015684-q10sx1dm	349	15	%	%	NN
cord-015684-q10sx1dm	349	16	;	;	,
cord-015684-q10sx1dm	349	17	*	*	NFP
cord-015684-q10sx1dm	349	18	5/	5/	CD
cord-015684-q10sx1dm	349	19	*	*	NFP
cord-015684-q10sx1dm	349	20	5	5	CD
cord-015684-q10sx1dm	349	21	,	,	,
cord-015684-q10sx1dm	349	22	0.65	0.65	CD
cord-015684-q10sx1dm	349	23	%	%	NN
cord-015684-q10sx1dm	349	24	;	;	.
cord-015684-q10sx1dm	350	1	*	*	NFP
cord-015684-q10sx1dm	350	2	1xN/	1xn/	CD
cord-015684-q10sx1dm	350	3	*	*	SYM
cord-015684-q10sx1dm	350	4	1	1	CD
cord-015684-q10sx1dm	350	5	,	,	,
cord-015684-q10sx1dm	350	6	4.52	4.52	CD
cord-015684-q10sx1dm	350	7	%	%	NN
cord-015684-q10sx1dm	350	8	;	;	.
cord-015684-q10sx1dm	351	1	*	*	NFP
cord-015684-q10sx1dm	351	2	1xN/	1xn/	CD
cord-015684-q10sx1dm	351	3	*	*	NFP
cord-015684-q10sx1dm	351	4	4	4	CD
cord-015684-q10sx1dm	351	5	,	,	,
cord-015684-q10sx1dm	351	6	1.95	1.95	CD
cord-015684-q10sx1dm	351	7	%	%	NN
cord-015684-q10sx1dm	351	8	;	;	,
cord-015684-q10sx1dm	351	9	and	and	CC
cord-015684-q10sx1dm	351	10	Dupl	Dupl	NNP
cord-015684-q10sx1dm	351	11	,	,	,
cord-015684-q10sx1dm	351	12	0.65	0.65	CD
cord-015684-q10sx1dm	351	13	%	%	NN
cord-015684-q10sx1dm	351	14	.	.	.
cord-015684-q10sx1dm	352	1	20	20	CD
cord-015684-q10sx1dm	352	2	,	,	,
cord-015684-q10sx1dm	352	3	[	[	-LRB-
cord-015684-q10sx1dm	352	4	74	74	CD
cord-015684-q10sx1dm	352	5	]	]	-RRB-
cord-015684-q10sx1dm	352	6	[	[	-LRB-
cord-015684-q10sx1dm	352	7	75	75	CD
cord-015684-q10sx1dm	352	8	]	]	-RRB-
cord-015684-q10sx1dm	352	9	[	[	-LRB-
cord-015684-q10sx1dm	352	10	76	76	CD
cord-015684-q10sx1dm	352	11	]	]	-RRB-
cord-015684-q10sx1dm	352	12	[	[	-LRB-
cord-015684-q10sx1dm	352	13	77	77	CD
cord-015684-q10sx1dm	352	14	]	]	-RRB-
cord-015684-q10sx1dm	353	1	In	in	IN
cord-015684-q10sx1dm	353	2	some	some	DT
cord-015684-q10sx1dm	353	3	instances	instance	NNS
cord-015684-q10sx1dm	353	4	,	,	,
cord-015684-q10sx1dm	353	5	there	there	EX
cord-015684-q10sx1dm	353	6	is	be	VBZ
cord-015684-q10sx1dm	353	7	association	association	NN
cord-015684-q10sx1dm	353	8	of	of	IN
cord-015684-q10sx1dm	353	9	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	353	10	variants	variant	NNS
cord-015684-q10sx1dm	353	11	of	of	IN
cord-015684-q10sx1dm	353	12	risk	risk	NN
cord-015684-q10sx1dm	353	13	with	with	IN
cord-015684-q10sx1dm	353	14	genes	gene	NNS
cord-015684-q10sx1dm	353	15	potentially	potentially	RB
cord-015684-q10sx1dm	353	16	involved	involve	VBN
cord-015684-q10sx1dm	353	17	in	in	IN
cord-015684-q10sx1dm	353	18	the	the	DT
cord-015684-q10sx1dm	353	19	pathogenesis	pathogenesis	NN
cord-015684-q10sx1dm	353	20	of	of	IN
cord-015684-q10sx1dm	353	21	specifi	specifi	NN
cord-015684-q10sx1dm	353	22	c	c	NN
cord-015684-q10sx1dm	353	23	CNS	CNS	NNP
cord-015684-q10sx1dm	353	24	disorders	disorder	NNS
cord-015684-q10sx1dm	353	25	.	.	.
cord-015684-q10sx1dm	354	1	When	when	WRB
cord-015684-q10sx1dm	354	2	comparing	compare	VBG
cord-015684-q10sx1dm	354	3	AD	ad	NN
cord-015684-q10sx1dm	354	4	cases	case	NNS
cord-015684-q10sx1dm	354	5	with	with	IN
cord-015684-q10sx1dm	354	6	controls	control	NNS
cord-015684-q10sx1dm	354	7	,	,	,
cord-015684-q10sx1dm	354	8	we	-PRON-	PRP
cord-015684-q10sx1dm	354	9	observed	observe	VBD
cord-015684-q10sx1dm	354	10	that	that	IN
cord-015684-q10sx1dm	354	11	EMs	EMs	NNP
cord-015684-q10sx1dm	354	12	are	be	VBP
cord-015684-q10sx1dm	354	13	more	more	RBR
cord-015684-q10sx1dm	354	14	prevalent	prevalent	JJ
cord-015684-q10sx1dm	354	15	in	in	IN
cord-015684-q10sx1dm	354	16	AD	ad	NN
cord-015684-q10sx1dm	354	17	(	(	-LRB-
cord-015684-q10sx1dm	354	18	*	*	NFP
cord-015684-q10sx1dm	354	19	1/	1/	CD
cord-015684-q10sx1dm	354	20	*	*	SYM
cord-015684-q10sx1dm	354	21	1	1	CD
cord-015684-q10sx1dm	354	22	,	,	,
cord-015684-q10sx1dm	354	23	49.42	49.42	CD
cord-015684-q10sx1dm	354	24	%	%	NN
cord-015684-q10sx1dm	354	25	;	;	:
cord-015684-q10sx1dm	354	26	*	*	NFP
cord-015684-q10sx1dm	354	27	1/	1/	CD
cord-015684-q10sx1dm	354	28	*	*	NFP
cord-015684-q10sx1dm	354	29	10	10	CD
cord-015684-q10sx1dm	354	30	,	,	,
cord-015684-q10sx1dm	354	31	8.04%)(total	8.04%)(total	CD
cord-015684-q10sx1dm	354	32	AD	ad	NN
cord-015684-q10sx1dm	354	33	-	-	HYPH
cord-015684-q10sx1dm	354	34	EMs	EMs	NNP
cord-015684-q10sx1dm	354	35	:	:	:
cord-015684-q10sx1dm	354	36	57.47	57.47	CD
cord-015684-q10sx1dm	354	37	%	%	NN
cord-015684-q10sx1dm	354	38	)	)	-RRB-
cord-015684-q10sx1dm	354	39	than	than	IN
cord-015684-q10sx1dm	354	40	in	in	IN
cord-015684-q10sx1dm	354	41	controls	control	NNS
cord-015684-q10sx1dm	354	42	(	(	-LRB-
cord-015684-q10sx1dm	354	43	*	*	NFP
cord-015684-q10sx1dm	354	44	1/	1/	CD
cord-015684-q10sx1dm	354	45	*	*	SYM
cord-015684-q10sx1dm	354	46	1	1	CD
cord-015684-q10sx1dm	354	47	,	,	,
cord-015684-q10sx1dm	354	48	44.12	44.12	CD
cord-015684-q10sx1dm	354	49	%	%	NN
cord-015684-q10sx1dm	354	50	;	;	:
cord-015684-q10sx1dm	354	51	*	*	NFP
cord-015684-q10sx1dm	354	52	1/	1/	CD
cord-015684-q10sx1dm	354	53	*	*	NFP
cord-015684-q10sx1dm	354	54	10	10	CD
cord-015684-q10sx1dm	354	55	,	,	,
cord-015684-q10sx1dm	354	56	0%)(total	0%)(total	CD
cord-015684-q10sx1dm	355	1	C	C	NNP
cord-015684-q10sx1dm	355	2	-	-	HYPH
cord-015684-q10sx1dm	355	3	EMs	EMs	NNP
cord-015684-q10sx1dm	355	4	:	:	:
cord-015684-q10sx1dm	355	5	44.12	44.12	CD
cord-015684-q10sx1dm	355	6	%	%	NN
cord-015684-q10sx1dm	355	7	)	)	-RRB-
cord-015684-q10sx1dm	355	8	.	.	.
cord-015684-q10sx1dm	356	1	In	in	IN
cord-015684-q10sx1dm	356	2	contrast	contrast	NN
cord-015684-q10sx1dm	356	3	,	,	,
cord-015684-q10sx1dm	356	4	IMs	IMs	NNP
cord-015684-q10sx1dm	356	5	are	be	VBP
cord-015684-q10sx1dm	356	6	more	more	RBR
cord-015684-q10sx1dm	356	7	frequent	frequent	JJ
cord-015684-q10sx1dm	356	8	in	in	IN
cord-015684-q10sx1dm	356	9	controls	control	NNS
cord-015684-q10sx1dm	356	10	(	(	-LRB-
cord-015684-q10sx1dm	356	11	41.18	41.18	CD
cord-015684-q10sx1dm	356	12	%	%	NN
cord-015684-q10sx1dm	356	13	)	)	-RRB-
cord-015684-q10sx1dm	356	14	than	than	IN
cord-015684-q10sx1dm	356	15	in	in	IN
cord-015684-q10sx1dm	356	16	AD	ad	NN
cord-015684-q10sx1dm	356	17	(	(	-LRB-
cord-015684-q10sx1dm	356	18	25.29	25.29	CD
cord-015684-q10sx1dm	356	19	%	%	NN
cord-015684-q10sx1dm	356	20	)	)	-RRB-
cord-015684-q10sx1dm	356	21	,	,	,
cord-015684-q10sx1dm	356	22	especially	especially	RB
cord-015684-q10sx1dm	356	23	the	the	DT
cord-015684-q10sx1dm	356	24	*	*	NFP
cord-015684-q10sx1dm	356	25	1/	1/	CD
cord-015684-q10sx1dm	356	26	*	*	NFP
cord-015684-q10sx1dm	356	27	4	4	CD
cord-015684-q10sx1dm	356	28	(	(	-LRB-
cord-015684-q10sx1dm	356	29	C	c	NN
cord-015684-q10sx1dm	356	30	:	:	:
cord-015684-q10sx1dm	356	31	23.53	23.53	CD
cord-015684-q10sx1dm	356	32	%	%	NN
cord-015684-q10sx1dm	356	33	;	;	:
cord-015684-q10sx1dm	356	34	AD	ad	NN
cord-015684-q10sx1dm	356	35	:	:	:
cord-015684-q10sx1dm	356	36	12.64	12.64	CD
cord-015684-q10sx1dm	356	37	%	%	NN
cord-015684-q10sx1dm	356	38	)	)	-RRB-
cord-015684-q10sx1dm	357	1	and	and	CC
cord-015684-q10sx1dm	357	2	*	*	NFP
cord-015684-q10sx1dm	357	3	4/	4/	CD
cord-015684-q10sx1dm	357	4	*	*	NFP
cord-015684-q10sx1dm	357	5	10	10	CD
cord-015684-q10sx1dm	357	6	genotypes	genotype	NNS
cord-015684-q10sx1dm	357	7	(	(	-LRB-
cord-015684-q10sx1dm	357	8	C	c	NN
cord-015684-q10sx1dm	357	9	:	:	:
cord-015684-q10sx1dm	357	10	5.88	5.88	CD
cord-015684-q10sx1dm	357	11	%	%	NN
cord-015684-q10sx1dm	357	12	;	;	:
cord-015684-q10sx1dm	357	13	AD	ad	NN
cord-015684-q10sx1dm	357	14	:	:	:
cord-015684-q10sx1dm	357	15	1.15	1.15	CD
cord-015684-q10sx1dm	357	16	%	%	NN
cord-015684-q10sx1dm	357	17	)	)	-RRB-
cord-015684-q10sx1dm	357	18	.	.	.
cord-015684-q10sx1dm	358	1	The	the	DT
cord-015684-q10sx1dm	358	2	frequency	frequency	NN
cord-015684-q10sx1dm	358	3	of	of	IN
cord-015684-q10sx1dm	358	4	PMs	pms	NN
cord-015684-q10sx1dm	358	5	was	be	VBD
cord-015684-q10sx1dm	358	6	similar	similar	JJ
cord-015684-q10sx1dm	358	7	in	in	IN
cord-015684-q10sx1dm	358	8	AD	ad	NN
cord-015684-q10sx1dm	358	9	(	(	-LRB-
cord-015684-q10sx1dm	358	10	9.20	9.20	CD
cord-015684-q10sx1dm	358	11	%	%	NN
cord-015684-q10sx1dm	358	12	)	)	-RRB-
cord-015684-q10sx1dm	358	13	and	and	CC
cord-015684-q10sx1dm	358	14	controls	control	NNS
cord-015684-q10sx1dm	358	15	(	(	-LRB-
cord-015684-q10sx1dm	358	16	8.82	8.82	CD
cord-015684-q10sx1dm	358	17	%	%	NN
cord-015684-q10sx1dm	358	18	)	)	-RRB-
cord-015684-q10sx1dm	358	19	,	,	,
cord-015684-q10sx1dm	358	20	and	and	CC
cord-015684-q10sx1dm	358	21	UMs	um	NNS
cord-015684-q10sx1dm	358	22	were	be	VBD
cord-015684-q10sx1dm	358	23	more	more	RBR
cord-015684-q10sx1dm	358	24	frequent	frequent	JJ
cord-015684-q10sx1dm	358	25	among	among	IN
cord-015684-q10sx1dm	358	26	AD	ad	NN
cord-015684-q10sx1dm	358	27	cases	case	NNS
cord-015684-q10sx1dm	358	28	(	(	-LRB-
cord-015684-q10sx1dm	358	29	8.04	8.04	CD
cord-015684-q10sx1dm	358	30	%	%	NN
cord-015684-q10sx1dm	358	31	)	)	-RRB-
cord-015684-q10sx1dm	358	32	than	than	IN
cord-015684-q10sx1dm	358	33	in	in	IN
cord-015684-q10sx1dm	358	34	controls	control	NNS
cord-015684-q10sx1dm	358	35	(	(	-LRB-
cord-015684-q10sx1dm	358	36	5.88	5.88	CD
cord-015684-q10sx1dm	358	37	%	%	NN
cord-015684-q10sx1dm	358	38	)	)	-RRB-
cord-015684-q10sx1dm	358	39	.	.	.
cord-015684-q10sx1dm	359	1	20	20	CD
cord-015684-q10sx1dm	359	2	,	,	,
cord-015684-q10sx1dm	359	3	74	74	CD
cord-015684-q10sx1dm	359	4	,	,	,
cord-015684-q10sx1dm	359	5	75	75	CD
cord-015684-q10sx1dm	359	6	,	,	,
cord-015684-q10sx1dm	359	7	77	77	CD
cord-015684-q10sx1dm	359	8	 	 	_SP
cord-015684-q10sx1dm	360	1	We	-PRON-	PRP
cord-015684-q10sx1dm	360	2	have	have	VBP
cord-015684-q10sx1dm	360	3	also	also	RB
cord-015684-q10sx1dm	360	4	investigated	investigate	VBN
cord-015684-q10sx1dm	360	5	the	the	DT
cord-015684-q10sx1dm	360	6	association	association	NN
cord-015684-q10sx1dm	360	7	of	of	IN
cord-015684-q10sx1dm	360	8	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	360	9	genotypes	genotype	NNS
cord-015684-q10sx1dm	360	10	with	with	IN
cord-015684-q10sx1dm	360	11	AD	ad	NN
cord-015684-q10sx1dm	360	12	-	-	HYPH
cord-015684-q10sx1dm	360	13	related	relate	VBN
cord-015684-q10sx1dm	360	14	genes	gene	NNS
cord-015684-q10sx1dm	360	15	,	,	,
cord-015684-q10sx1dm	360	16	such	such	JJ
cord-015684-q10sx1dm	360	17	as	as	IN
cord-015684-q10sx1dm	360	18	APP	app	NN
cord-015684-q10sx1dm	360	19	,	,	,
cord-015684-q10sx1dm	360	20	MAPT	MAPT	NNP
cord-015684-q10sx1dm	360	21	,	,	,
cord-015684-q10sx1dm	360	22	APOE	APOE	NNP
cord-015684-q10sx1dm	360	23	,	,	,
cord-015684-q10sx1dm	360	24	PS1	PS1	NNP
cord-015684-q10sx1dm	360	25	,	,	,
cord-015684-q10sx1dm	360	26	PS2	PS2	NNP
cord-015684-q10sx1dm	360	27	,	,	,
cord-015684-q10sx1dm	360	28	A2	A2	NNP
cord-015684-q10sx1dm	360	29	M	M	NNP
cord-015684-q10sx1dm	360	30	,	,	,
cord-015684-q10sx1dm	360	31	ACE	ACE	NNP
cord-015684-q10sx1dm	360	32	,	,	,
cord-015684-q10sx1dm	360	33	AGT	AGT	NNP
cord-015684-q10sx1dm	360	34	,	,	,
cord-015684-q10sx1dm	360	35	FOS	FOS	NNP
cord-015684-q10sx1dm	360	36	,	,	,
cord-015684-q10sx1dm	360	37	and	and	CC
cord-015684-q10sx1dm	360	38	PRNP	prnp	NN
cord-015684-q10sx1dm	360	39	variants	variant	NNS
cord-015684-q10sx1dm	360	40	.	.	.
cord-015684-q10sx1dm	361	1	20	20	CD
cord-015684-q10sx1dm	361	2	,	,	,
cord-015684-q10sx1dm	361	3	74	74	CD
cord-015684-q10sx1dm	361	4	,	,	,
cord-015684-q10sx1dm	361	5	75	75	CD
cord-015684-q10sx1dm	361	6	,	,	,
cord-015684-q10sx1dm	361	7	77	77	CD
cord-015684-q10sx1dm	362	1	No	no	DT
cord-015684-q10sx1dm	362	2	APP	app	NN
cord-015684-q10sx1dm	362	3	or	or	CC
cord-015684-q10sx1dm	362	4	MAPT	MAPT	NNP
cord-015684-q10sx1dm	362	5	mutations	mutation	NNS
cord-015684-q10sx1dm	362	6	have	have	VBP
cord-015684-q10sx1dm	362	7	been	be	VBN
cord-015684-q10sx1dm	362	8	found	find	VBN
cord-015684-q10sx1dm	362	9	in	in	IN
cord-015684-q10sx1dm	362	10	AD	ad	NN
cord-015684-q10sx1dm	362	11	cases	case	NNS
cord-015684-q10sx1dm	362	12	.	.	.
cord-015684-q10sx1dm	363	1	Homozygous	Homozygous	NNP
cord-015684-q10sx1dm	363	2	APOE-2/2	APOE-2/2	NNP
cord-015684-q10sx1dm	363	3	(	(	-LRB-
cord-015684-q10sx1dm	363	4	12.56	12.56	CD
cord-015684-q10sx1dm	363	5	%	%	NN
cord-015684-q10sx1dm	363	6	)	)	-RRB-
cord-015684-q10sx1dm	363	7	and	and	CC
cord-015684-q10sx1dm	363	8	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	363	9	(	(	-LRB-
cord-015684-q10sx1dm	363	10	12.50	12.50	CD
cord-015684-q10sx1dm	363	11	%	%	NN
cord-015684-q10sx1dm	363	12	)	)	-RRB-
cord-015684-q10sx1dm	363	13	accumulate	accumulate	VBP
cord-015684-q10sx1dm	363	14	in	in	IN
cord-015684-q10sx1dm	363	15	UMs	um	NNS
cord-015684-q10sx1dm	363	16	,	,	,
cord-015684-q10sx1dm	363	17	and	and	CC
cord-015684-q10sx1dm	363	18	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	363	19	cases	case	NNS
cord-015684-q10sx1dm	363	20	were	be	VBD
cord-015684-q10sx1dm	363	21	also	also	RB
cord-015684-q10sx1dm	363	22	more	more	RBR
cord-015684-q10sx1dm	363	23	frequent	frequent	JJ
cord-015684-q10sx1dm	363	24	in	in	IN
cord-015684-q10sx1dm	363	25	PMs	pm	NNS
cord-015684-q10sx1dm	363	26	(	(	-LRB-
cord-015684-q10sx1dm	363	27	6.66	6.66	CD
cord-015684-q10sx1dm	363	28	%	%	NN
cord-015684-q10sx1dm	363	29	)	)	-RRB-
cord-015684-q10sx1dm	363	30	than	than	IN
cord-015684-q10sx1dm	363	31	in	in	IN
cord-015684-q10sx1dm	363	32	EMs	EMs	NNP
cord-015684-q10sx1dm	363	33	(	(	-LRB-
cord-015684-q10sx1dm	363	34	3.95	3.95	CD
cord-015684-q10sx1dm	363	35	%	%	NN
cord-015684-q10sx1dm	363	36	)	)	-RRB-
cord-015684-q10sx1dm	363	37	or	or	CC
cord-015684-q10sx1dm	363	38	IMs	IMs	NNP
cord-015684-q10sx1dm	363	39	(	(	-LRB-
cord-015684-q10sx1dm	363	40	0	0	CD
cord-015684-q10sx1dm	363	41	%	%	NN
cord-015684-q10sx1dm	363	42	)	)	-RRB-
cord-015684-q10sx1dm	363	43	.	.	.
cord-015684-q10sx1dm	364	1	PS1	PS1	NNP
cord-015684-q10sx1dm	364	2	-	-	HYPH
cord-015684-q10sx1dm	364	3	1/1	1/1	CD
cord-015684-q10sx1dm	364	4	genotypes	genotype	NNS
cord-015684-q10sx1dm	364	5	were	be	VBD
cord-015684-q10sx1dm	364	6	more	more	RBR
cord-015684-q10sx1dm	364	7	frequent	frequent	JJ
cord-015684-q10sx1dm	364	8	in	in	IN
cord-015684-q10sx1dm	364	9	EMs	EMs	NNP
cord-015684-q10sx1dm	364	10	(	(	-LRB-
cord-015684-q10sx1dm	364	11	45	45	CD
cord-015684-q10sx1dm	364	12	%	%	NN
cord-015684-q10sx1dm	364	13	)	)	-RRB-
cord-015684-q10sx1dm	364	14	,	,	,
cord-015684-q10sx1dm	364	15	whereas	whereas	IN
cord-015684-q10sx1dm	364	16	PS-1/2	ps-1/2	JJ
cord-015684-q10sx1dm	364	17	genotypes	genotype	NNS
cord-015684-q10sx1dm	364	18	were	be	VBD
cord-015684-q10sx1dm	364	19	over	over	RB
cord-015684-q10sx1dm	364	20	-	-	HYPH
cord-015684-q10sx1dm	364	21	represented	represent	VBN
cord-015684-q10sx1dm	364	22	in	in	IN
cord-015684-q10sx1dm	364	23	IMs	IMs	NNP
cord-015684-q10sx1dm	364	24	(	(	-LRB-
cord-015684-q10sx1dm	364	25	63.16	63.16	CD
cord-015684-q10sx1dm	364	26	%	%	NN
cord-015684-q10sx1dm	364	27	)	)	-RRB-
cord-015684-q10sx1dm	364	28	and	and	CC
cord-015684-q10sx1dm	364	29	UMs	UMs	NNPS
cord-015684-q10sx1dm	364	30	(	(	-LRB-
cord-015684-q10sx1dm	364	31	60	60	CD
cord-015684-q10sx1dm	364	32	%	%	NN
cord-015684-q10sx1dm	364	33	)	)	-RRB-
cord-015684-q10sx1dm	364	34	.	.	.
cord-015684-q10sx1dm	365	1	The	the	DT
cord-015684-q10sx1dm	365	2	presence	presence	NN
cord-015684-q10sx1dm	365	3	of	of	IN
cord-015684-q10sx1dm	365	4	the	the	DT
cord-015684-q10sx1dm	365	5	PS1	PS1	NNP
cord-015684-q10sx1dm	365	6	-	-	HYPH
cord-015684-q10sx1dm	365	7	2/2	2/2	CD
cord-015684-q10sx1dm	365	8	genotype	genotype	NN
cord-015684-q10sx1dm	365	9	was	be	VBD
cord-015684-q10sx1dm	365	10	especially	especially	RB
cord-015684-q10sx1dm	365	11	high	high	JJ
cord-015684-q10sx1dm	365	12	in	in	IN
cord-015684-q10sx1dm	365	13	PMs	PMs	NNP
cord-015684-q10sx1dm	365	14	(	(	-LRB-
cord-015684-q10sx1dm	365	15	38.46	38.46	CD
cord-015684-q10sx1dm	365	16	%	%	NN
cord-015684-q10sx1dm	365	17	)	)	-RRB-
cord-015684-q10sx1dm	365	18	and	and	CC
cord-015684-q10sx1dm	365	19	UMs	UMs	NNPS
cord-015684-q10sx1dm	365	20	(	(	-LRB-
cord-015684-q10sx1dm	365	21	20	20	CD
cord-015684-q10sx1dm	365	22	%	%	NN
cord-015684-q10sx1dm	365	23	)	)	-RRB-
cord-015684-q10sx1dm	365	24	.	.	.
cord-015684-q10sx1dm	366	1	A	a	DT
cord-015684-q10sx1dm	366	2	mutation	mutation	NN
cord-015684-q10sx1dm	366	3	in	in	IN
cord-015684-q10sx1dm	366	4	the	the	DT
cord-015684-q10sx1dm	366	5	PS2	PS2	NNP
cord-015684-q10sx1dm	366	6	gene	gene	NN
cord-015684-q10sx1dm	366	7	exon	exon	NN
cord-015684-q10sx1dm	366	8	5	5	CD
cord-015684-q10sx1dm	367	1	(	(	-LRB-
cord-015684-q10sx1dm	367	2	PS2E5	ps2e5	NN
cord-015684-q10sx1dm	367	3	+	+	CC
cord-015684-q10sx1dm	367	4	)	)	-RRB-
cord-015684-q10sx1dm	367	5	was	be	VBD
cord-015684-q10sx1dm	367	6	markedly	markedly	RB
cord-015684-q10sx1dm	367	7	present	present	JJ
cord-015684-q10sx1dm	367	8	in	in	IN
cord-015684-q10sx1dm	367	9	UMs	UMs	NNP
cord-015684-q10sx1dm	367	10	(	(	-LRB-
cord-015684-q10sx1dm	367	11	66.67	66.67	CD
cord-015684-q10sx1dm	367	12	%	%	NN
cord-015684-q10sx1dm	367	13	)	)	-RRB-
cord-015684-q10sx1dm	367	14	.	.	.
cord-015684-q10sx1dm	368	1	About	about	RB
cord-015684-q10sx1dm	368	2	100	100	CD
cord-015684-q10sx1dm	368	3	%	%	NN
cord-015684-q10sx1dm	368	4	of	of	IN
cord-015684-q10sx1dm	368	5	UMs	um	NNS
cord-015684-q10sx1dm	368	6	were	be	VBD
cord-015684-q10sx1dm	368	7	A2M	a2m	JJ
cord-015684-q10sx1dm	368	8	-	-	HYPH
cord-015684-q10sx1dm	368	9	V100I	v100i	NN
cord-015684-q10sx1dm	368	10	-	-	HYPH
cord-015684-q10sx1dm	368	11	A	A	NNP
cord-015684-q10sx1dm	368	12	/	/	SYM
cord-015684-q10sx1dm	368	13	A	A	NNP
cord-015684-q10sx1dm	368	14	,	,	,
cord-015684-q10sx1dm	368	15	and	and	CC
cord-015684-q10sx1dm	368	16	the	the	DT
cord-015684-q10sx1dm	368	17	A2M	a2m	NN
cord-015684-q10sx1dm	368	18	-	-	HYPH
cord-015684-q10sx1dm	368	19	V100I	v100i	NN
cord-015684-q10sx1dm	368	20	-	-	HYPH
cord-015684-q10sx1dm	368	21	G	g	NN
cord-015684-q10sx1dm	368	22	/	/	SYM
cord-015684-q10sx1dm	368	23	G	g	NN
cord-015684-q10sx1dm	368	24	genotype	genotype	NN
cord-015684-q10sx1dm	368	25	was	be	VBD
cord-015684-q10sx1dm	368	26	absent	absent	JJ
cord-015684-q10sx1dm	368	27	in	in	IN
cord-015684-q10sx1dm	368	28	PMs	pm	NNS
cord-015684-q10sx1dm	368	29	and	and	CC
cord-015684-q10sx1dm	368	30	UMs	um	NNS
cord-015684-q10sx1dm	368	31	.	.	.
cord-015684-q10sx1dm	369	1	The	the	DT
cord-015684-q10sx1dm	369	2	A2M	a2m	NN
cord-015684-q10sx1dm	369	3	-	-	HYPH
cord-015684-q10sx1dm	369	4	I	I	NNP
cord-015684-q10sx1dm	369	5	/	/	,
cord-015684-q10sx1dm	369	6	I	-PRON-	PRP
cord-015684-q10sx1dm	369	7	genotype	genotype	NN
cord-015684-q10sx1dm	369	8	was	be	VBD
cord-015684-q10sx1dm	369	9	absent	absent	JJ
cord-015684-q10sx1dm	369	10	in	in	IN
cord-015684-q10sx1dm	369	11	UMs	um	NNS
cord-015684-q10sx1dm	369	12	,	,	,
cord-015684-q10sx1dm	369	13	and	and	CC
cord-015684-q10sx1dm	369	14	100	100	CD
cord-015684-q10sx1dm	369	15	%	%	NN
cord-015684-q10sx1dm	369	16	of	of	IN
cord-015684-q10sx1dm	369	17	UMs	um	NNS
cord-015684-q10sx1dm	369	18	were	be	VBD
cord-015684-q10sx1dm	369	19	A2M	A2M	NNP
cord-015684-q10sx1dm	369	20	-	-	HYPH
cord-015684-q10sx1dm	369	21	I	I	NNP
cord-015684-q10sx1dm	369	22	/	/	SYM
cord-015684-q10sx1dm	369	23	D	D	NNP
cord-015684-q10sx1dm	369	24	and	and	CC
cord-015684-q10sx1dm	369	25	ACE	ace	NN
cord-015684-q10sx1dm	369	26	-	-	HYPH
cord-015684-q10sx1dm	369	27	D	D	NNP
cord-015684-q10sx1dm	370	1	/D.	/D.	NNP
cord-015684-q10sx1dm	370	2	Homozygous	Homozygous	NNP
cord-015684-q10sx1dm	370	3	mutations	mutation	NNS
cord-015684-q10sx1dm	370	4	in	in	IN
cord-015684-q10sx1dm	370	5	the	the	DT
cord-015684-q10sx1dm	370	6	FOS	FOS	NNP
cord-015684-q10sx1dm	370	7	gene	gene	NN
cord-015684-q10sx1dm	370	8	(	(	-LRB-
cord-015684-q10sx1dm	370	9	B	b	NN
cord-015684-q10sx1dm	370	10	/	/	SYM
cord-015684-q10sx1dm	370	11	B	b	NN
cord-015684-q10sx1dm	370	12	)	)	-RRB-
cord-015684-q10sx1dm	370	13	were	be	VBD
cord-015684-q10sx1dm	370	14	only	only	RB
cord-015684-q10sx1dm	370	15	present	present	JJ
cord-015684-q10sx1dm	370	16	in	in	IN
cord-015684-q10sx1dm	370	17	UMs	UMs	NNP
cord-015684-q10sx1dm	370	18	,	,	,
cord-015684-q10sx1dm	370	19	as	as	RB
cord-015684-q10sx1dm	370	20	well	well	RB
cord-015684-q10sx1dm	370	21	.	.	.
cord-015684-q10sx1dm	371	1	AGT	AGT	NNP
cord-015684-q10sx1dm	371	2	-	-	HYPH
cord-015684-q10sx1dm	371	3	T235	T235	NNP
cord-015684-q10sx1dm	371	4	T	t	NN
cord-015684-q10sx1dm	371	5	cases	case	NNS
cord-015684-q10sx1dm	371	6	were	be	VBD
cord-015684-q10sx1dm	371	7	absent	absent	JJ
cord-015684-q10sx1dm	371	8	in	in	IN
cord-015684-q10sx1dm	371	9	PMs	pm	NNS
cord-015684-q10sx1dm	371	10	,	,	,
cord-015684-q10sx1dm	371	11	and	and	CC
cord-015684-q10sx1dm	371	12	the	the	DT
cord-015684-q10sx1dm	371	13	AGT	AGT	NNP
cord-015684-q10sx1dm	371	14	-	-	HYPH
cord-015684-q10sx1dm	371	15	M174	M174	NNP
cord-015684-q10sx1dm	371	16	M	M	NNP
cord-015684-q10sx1dm	371	17	genotype	genotype	NN
cord-015684-q10sx1dm	371	18	appeared	appear	VBD
cord-015684-q10sx1dm	371	19	in	in	IN
cord-015684-q10sx1dm	371	20	100	100	CD
cord-015684-q10sx1dm	371	21	%	%	NN
cord-015684-q10sx1dm	371	22	of	of	IN
cord-015684-q10sx1dm	371	23	PMs	pm	NNS
cord-015684-q10sx1dm	371	24	.	.	.
cord-015684-q10sx1dm	372	1	Likewise	likewise	RB
cord-015684-q10sx1dm	372	2	,	,	,
cord-015684-q10sx1dm	372	3	the	the	DT
cord-015684-q10sx1dm	372	4	PRNP	PRNP	NNP
cord-015684-q10sx1dm	372	5	-	-	HYPH
cord-015684-q10sx1dm	372	6	M129	M129	NNP
cord-015684-q10sx1dm	372	7	M	M	NNP
cord-015684-q10sx1dm	372	8	variant	variant	NN
cord-015684-q10sx1dm	372	9	was	be	VBD
cord-015684-q10sx1dm	372	10	present	present	JJ
cord-015684-q10sx1dm	372	11	in	in	IN
cord-015684-q10sx1dm	372	12	100	100	CD
cord-015684-q10sx1dm	372	13	%	%	NN
cord-015684-q10sx1dm	372	14	of	of	IN
cord-015684-q10sx1dm	372	15	PMs	pm	NNS
cord-015684-q10sx1dm	372	16	and	and	CC
cord-015684-q10sx1dm	372	17	UMs	um	NNS
cord-015684-q10sx1dm	372	18	.	.	.
cord-015684-q10sx1dm	373	1	20	20	CD
cord-015684-q10sx1dm	373	2	,	,	,
cord-015684-q10sx1dm	373	3	74	74	CD
cord-015684-q10sx1dm	373	4	,	,	,
cord-015684-q10sx1dm	373	5	75	75	CD
cord-015684-q10sx1dm	373	6	,	,	,
cord-015684-q10sx1dm	373	7	77	77	CD
cord-015684-q10sx1dm	374	1	These	these	DT
cord-015684-q10sx1dm	374	2	association	association	NN
cord-015684-q10sx1dm	374	3	studies	study	NNS
cord-015684-q10sx1dm	374	4	clearly	clearly	RB
cord-015684-q10sx1dm	374	5	show	show	VBP
cord-015684-q10sx1dm	374	6	that	that	IN
cord-015684-q10sx1dm	374	7	in	in	IN
cord-015684-q10sx1dm	374	8	PMs	PMs	NNP
cord-015684-q10sx1dm	374	9	and	and	CC
cord-015684-q10sx1dm	374	10	UMs	UMs	NNPS
cord-015684-q10sx1dm	374	11	there	there	EX
cord-015684-q10sx1dm	374	12	is	be	VBZ
cord-015684-q10sx1dm	374	13	an	an	DT
cord-015684-q10sx1dm	374	14	accumulation	accumulation	NN
cord-015684-q10sx1dm	374	15	of	of	IN
cord-015684-q10sx1dm	374	16	AD	ad	NN
cord-015684-q10sx1dm	374	17	-	-	HYPH
cord-015684-q10sx1dm	374	18	related	relate	VBN
cord-015684-q10sx1dm	374	19	polymorphic	polymorphic	JJ
cord-015684-q10sx1dm	374	20	variants	variant	NNS
cord-015684-q10sx1dm	374	21	of	of	IN
cord-015684-q10sx1dm	374	22	risk	risk	NN
cord-015684-q10sx1dm	374	23	which	which	WDT
cord-015684-q10sx1dm	374	24	might	may	MD
cord-015684-q10sx1dm	374	25	be	be	VB
cord-015684-q10sx1dm	374	26	responsible	responsible	JJ
cord-015684-q10sx1dm	374	27	for	for	IN
cord-015684-q10sx1dm	374	28	the	the	DT
cord-015684-q10sx1dm	374	29	defective	defective	JJ
cord-015684-q10sx1dm	374	30	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	374	31	responses	response	NNS
cord-015684-q10sx1dm	374	32	currently	currently	RB
cord-015684-q10sx1dm	374	33	seen	see	VBN
cord-015684-q10sx1dm	374	34	in	in	IN
cord-015684-q10sx1dm	374	35	these	these	DT
cord-015684-q10sx1dm	374	36	AD	ad	NN
cord-015684-q10sx1dm	374	37	clusters	cluster	NNS
cord-015684-q10sx1dm	374	38	.	.	.
cord-015684-q10sx1dm	375	1	20	20	CD
cord-015684-q10sx1dm	375	2	,	,	,
cord-015684-q10sx1dm	375	3	[	[	-LRB-
cord-015684-q10sx1dm	375	4	74	74	CD
cord-015684-q10sx1dm	375	5	]	]	-RRB-
cord-015684-q10sx1dm	375	6	[	[	-LRB-
cord-015684-q10sx1dm	375	7	75	75	CD
cord-015684-q10sx1dm	375	8	]	]	-RRB-
cord-015684-q10sx1dm	375	9	[	[	-LRB-
cord-015684-q10sx1dm	375	10	76	76	CD
cord-015684-q10sx1dm	375	11	]	]	-RRB-
cord-015684-q10sx1dm	376	1	[	[	-LRB-
cord-015684-q10sx1dm	376	2	77	77	CD
cord-015684-q10sx1dm	376	3	]	]	-RRB-
cord-015684-q10sx1dm	376	4	 	 	_SP
cord-015684-q10sx1dm	377	1	It	-PRON-	PRP
cord-015684-q10sx1dm	377	2	appears	appear	VBZ
cord-015684-q10sx1dm	377	3	that	that	IN
cord-015684-q10sx1dm	377	4	different	different	JJ
cord-015684-q10sx1dm	377	5	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	377	6	variants	variant	NNS
cord-015684-q10sx1dm	377	7	,	,	,
cord-015684-q10sx1dm	377	8	expressing	express	VBG
cord-015684-q10sx1dm	377	9	EMs	EMs	NNP
cord-015684-q10sx1dm	377	10	,	,	,
cord-015684-q10sx1dm	377	11	IMs	IMs	NNP
cord-015684-q10sx1dm	377	12	,	,	,
cord-015684-q10sx1dm	377	13	PMs	PMs	NNPS
cord-015684-q10sx1dm	377	14	,	,	,
cord-015684-q10sx1dm	377	15	and	and	CC
cord-015684-q10sx1dm	377	16	UMs	um	NNS
cord-015684-q10sx1dm	377	17	,	,	,
cord-015684-q10sx1dm	377	18	infl	infl	NN
cord-015684-q10sx1dm	377	19	uence	uence	NN
cord-015684-q10sx1dm	377	20	to	to	IN
cord-015684-q10sx1dm	377	21	some	some	DT
cord-015684-q10sx1dm	377	22	extent	extent	NN
cord-015684-q10sx1dm	377	23	several	several	JJ
cord-015684-q10sx1dm	377	24	biochemical	biochemical	JJ
cord-015684-q10sx1dm	377	25	parameters	parameter	NNS
cord-015684-q10sx1dm	377	26	,	,	,
cord-015684-q10sx1dm	377	27	liver	liver	NN
cord-015684-q10sx1dm	377	28	function	function	NN
cord-015684-q10sx1dm	377	29	,	,	,
cord-015684-q10sx1dm	377	30	and	and	CC
cord-015684-q10sx1dm	377	31	vascular	vascular	JJ
cord-015684-q10sx1dm	377	32	hemodynamic	hemodynamic	JJ
cord-015684-q10sx1dm	377	33	parameters	parameter	NNS
cord-015684-q10sx1dm	377	34	which	which	WDT
cord-015684-q10sx1dm	377	35	might	may	MD
cord-015684-q10sx1dm	377	36	affect	affect	VB
cord-015684-q10sx1dm	377	37	drug	drug	NN
cord-015684-q10sx1dm	377	38	effi	effi	NNP
cord-015684-q10sx1dm	377	39	cacy	cacy	NNP
cord-015684-q10sx1dm	377	40	and	and	CC
cord-015684-q10sx1dm	377	41	safety	safety	NN
cord-015684-q10sx1dm	377	42	.	.	.
cord-015684-q10sx1dm	378	1	Blood	blood	NN
cord-015684-q10sx1dm	378	2	glucose	glucose	NN
cord-015684-q10sx1dm	378	3	levels	level	NNS
cord-015684-q10sx1dm	378	4	are	be	VBP
cord-015684-q10sx1dm	378	5	found	find	VBN
cord-015684-q10sx1dm	378	6	elevated	elevate	VBN
cord-015684-q10sx1dm	378	7	in	in	IN
cord-015684-q10sx1dm	378	8	EMs	EMs	NNP
cord-015684-q10sx1dm	378	9	(	(	-LRB-
cord-015684-q10sx1dm	378	10	*	*	NFP
cord-015684-q10sx1dm	378	11	1/	1/	CD
cord-015684-q10sx1dm	378	12	*	*	NFP
cord-015684-q10sx1dm	378	13	1	1	CD
cord-015684-q10sx1dm	378	14	vs.	vs.	NN
cord-015684-q10sx1dm	379	1	*	*	NFP
cord-015684-q10sx1dm	379	2	4/	4/	CD
cord-015684-q10sx1dm	379	3	*	*	NFP
cord-015684-q10sx1dm	379	4	10	10	CD
cord-015684-q10sx1dm	379	5	,	,	,
cord-015684-q10sx1dm	379	6	p	p	NN
cord-015684-q10sx1dm	379	7	<	<	XX
cord-015684-q10sx1dm	379	8	0.05	0.05	CD
cord-015684-q10sx1dm	379	9	)	)	-RRB-
cord-015684-q10sx1dm	379	10	and	and	CC
cord-015684-q10sx1dm	379	11	in	in	IN
cord-015684-q10sx1dm	379	12	some	some	DT
cord-015684-q10sx1dm	379	13	IMs	im	NNS
cord-015684-q10sx1dm	379	14	(	(	-LRB-
cord-015684-q10sx1dm	379	15	*	*	NFP
cord-015684-q10sx1dm	379	16	4/	4/	CD
cord-015684-q10sx1dm	379	17	*	*	NFP
cord-015684-q10sx1dm	379	18	10	10	CD
cord-015684-q10sx1dm	379	19	vs.	vs.	NN
cord-015684-q10sx1dm	379	20	*	*	NFP
cord-015684-q10sx1dm	379	21	1xN/	1xn/	CD
cord-015684-q10sx1dm	379	22	*	*	NFP
cord-015684-q10sx1dm	379	23	4	4	CD
cord-015684-q10sx1dm	379	24	,	,	,
cord-015684-q10sx1dm	379	25	p	p	NN
cord-015684-q10sx1dm	379	26	<	<	XX
cord-015684-q10sx1dm	379	27	0.05	0.05	CD
cord-015684-q10sx1dm	379	28	)	)	-RRB-
cord-015684-q10sx1dm	379	29	,	,	,
cord-015684-q10sx1dm	379	30	whereas	whereas	IN
cord-015684-q10sx1dm	379	31	other	other	JJ
cord-015684-q10sx1dm	379	32	IMs	im	NNS
cord-015684-q10sx1dm	379	33	(	(	-LRB-
cord-015684-q10sx1dm	379	34	*	*	NFP
cord-015684-q10sx1dm	379	35	1/	1/	CD
cord-015684-q10sx1dm	379	36	*	*	NFP
cord-015684-q10sx1dm	379	37	5	5	CD
cord-015684-q10sx1dm	379	38	vs.	vs.	NN
cord-015684-q10sx1dm	380	1	*	*	NFP
cord-015684-q10sx1dm	380	2	4/	4/	CD
cord-015684-q10sx1dm	380	3	*	*	NFP
cord-015684-q10sx1dm	380	4	4	4	CD
cord-015684-q10sx1dm	380	5	,	,	,
cord-015684-q10sx1dm	380	6	p	p	NN
cord-015684-q10sx1dm	380	7	<	<	XX
cord-015684-q10sx1dm	380	8	0.05	0.05	CD
cord-015684-q10sx1dm	380	9	)	)	-RRB-
cord-015684-q10sx1dm	380	10	tend	tend	VBP
cord-015684-q10sx1dm	380	11	to	to	TO
cord-015684-q10sx1dm	380	12	show	show	VB
cord-015684-q10sx1dm	380	13	lower	low	JJR
cord-015684-q10sx1dm	380	14	levels	level	NNS
cord-015684-q10sx1dm	380	15	of	of	IN
cord-015684-q10sx1dm	380	16	glucose	glucose	NN
cord-015684-q10sx1dm	380	17	compared	compare	VBN
cord-015684-q10sx1dm	380	18	with	with	IN
cord-015684-q10sx1dm	380	19	PMs	pm	NNS
cord-015684-q10sx1dm	380	20	(	(	-LRB-
cord-015684-q10sx1dm	380	21	*	*	NFP
cord-015684-q10sx1dm	380	22	4/	4/	CD
cord-015684-q10sx1dm	380	23	*	*	NFP
cord-015684-q10sx1dm	380	24	4	4	CD
cord-015684-q10sx1dm	380	25	)	)	-RRB-
cord-015684-q10sx1dm	380	26	or	or	CC
cord-015684-q10sx1dm	380	27	UMs	UMs	NNPS
cord-015684-q10sx1dm	380	28	(	(	-LRB-
cord-015684-q10sx1dm	380	29	*	*	NFP
cord-015684-q10sx1dm	380	30	1xN/	1xn/	CD
cord-015684-q10sx1dm	380	31	*	*	NFP
cord-015684-q10sx1dm	380	32	4	4	CD
cord-015684-q10sx1dm	380	33	)	)	-RRB-
cord-015684-q10sx1dm	380	34	(	(	-LRB-
cord-015684-q10sx1dm	380	35	Table	table	NN
cord-015684-q10sx1dm	380	36	40	40	CD
cord-015684-q10sx1dm	380	37	.7	.7	NFP
cord-015684-q10sx1dm	380	38	)	)	-RRB-
cord-015684-q10sx1dm	380	39	.	.	.
cord-015684-q10sx1dm	381	1	The	the	DT
cord-015684-q10sx1dm	381	2	highest	high	JJS
cord-015684-q10sx1dm	381	3	levels	level	NNS
cord-015684-q10sx1dm	381	4	of	of	IN
cord-015684-q10sx1dm	381	5	total	total	JJ
cord-015684-q10sx1dm	381	6	-	-	HYPH
cord-015684-q10sx1dm	381	7	cholesterol	cholesterol	NN
cord-015684-q10sx1dm	381	8	are	be	VBP
cord-015684-q10sx1dm	381	9	detected	detect	VBN
cord-015684-q10sx1dm	381	10	in	in	IN
cord-015684-q10sx1dm	381	11	the	the	DT
cord-015684-q10sx1dm	381	12	EMs	em	NNS
cord-015684-q10sx1dm	381	13	with	with	IN
cord-015684-q10sx1dm	381	14	the	the	DT
cord-015684-q10sx1dm	381	15	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	381	16	*	*	NFP
cord-015684-q10sx1dm	381	17	1/	1/	CD
cord-015684-q10sx1dm	381	18	*	*	NFP
cord-015684-q10sx1dm	381	19	10	10	CD
cord-015684-q10sx1dm	381	20	genotype	genotype	NN
cord-015684-q10sx1dm	381	21	(	(	-LRB-
cord-015684-q10sx1dm	381	22	vs.	vs.	FW
cord-015684-q10sx1dm	382	1	*	*	NFP
cord-015684-q10sx1dm	382	2	1/	1/	CD
cord-015684-q10sx1dm	382	3	*	*	SYM
cord-015684-q10sx1dm	382	4	1	1	CD
cord-015684-q10sx1dm	382	5	,	,	,
cord-015684-q10sx1dm	382	6	*	*	NFP
cord-015684-q10sx1dm	382	7	1/	1/	CD
cord-015684-q10sx1dm	382	8	*	*	NFP
cord-015684-q10sx1dm	382	9	4	4	CD
cord-015684-q10sx1dm	382	10	and	and	CC
cord-015684-q10sx1dm	382	11	*	*	NFP
cord-015684-q10sx1dm	382	12	1xN/	1xn/	CD
cord-015684-q10sx1dm	382	13	*	*	SYM
cord-015684-q10sx1dm	382	14	1	1	CD
cord-015684-q10sx1dm	382	15	,	,	,
cord-015684-q10sx1dm	382	16	p	p	NN
cord-015684-q10sx1dm	382	17	<	<	XX
cord-015684-q10sx1dm	382	18	0.05	0.05	CD
cord-015684-q10sx1dm	382	19	)	)	-RRB-
cord-015684-q10sx1dm	382	20	.	.	.
cord-015684-q10sx1dm	383	1	The	the	DT
cord-015684-q10sx1dm	383	2	same	same	JJ
cord-015684-q10sx1dm	383	3	pattern	pattern	NN
cord-015684-q10sx1dm	383	4	has	have	VBZ
cord-015684-q10sx1dm	383	5	been	be	VBN
cord-015684-q10sx1dm	383	6	observed	observe	VBN
cord-015684-q10sx1dm	383	7	with	with	IN
cord-015684-q10sx1dm	383	8	regard	regard	NN
cord-015684-q10sx1dm	383	9	to	to	IN
cord-015684-q10sx1dm	383	10	LDLcholesterol	ldlcholesterol	JJ
cord-015684-q10sx1dm	383	11	levels	level	NNS
cord-015684-q10sx1dm	383	12	,	,	,
cord-015684-q10sx1dm	383	13	which	which	WDT
cord-015684-q10sx1dm	383	14	are	be	VBP
cord-015684-q10sx1dm	383	15	signifi	signifi	NNP
cord-015684-q10sx1dm	383	16	cantly	cantly	RB
cord-015684-q10sx1dm	383	17	higher	higher	RBR
cord-015684-q10sx1dm	383	18	in	in	IN
cord-015684-q10sx1dm	383	19	the	the	DT
cord-015684-q10sx1dm	383	20	EM-	EM-	NNP
cord-015684-q10sx1dm	383	21	*	*	NFP
cord-015684-q10sx1dm	383	22	1/	1/	CD
cord-015684-q10sx1dm	383	23	*	*	NFP
cord-015684-q10sx1dm	383	24	10	10	CD
cord-015684-q10sx1dm	383	25	.	.	.
cord-015684-q10sx1dm	384	1	In	in	IN
cord-015684-q10sx1dm	384	2	general	general	JJ
cord-015684-q10sx1dm	384	3	,	,	,
cord-015684-q10sx1dm	384	4	both	both	DT
cord-015684-q10sx1dm	384	5	total	total	JJ
cord-015684-q10sx1dm	384	6	cholesterol	cholesterol	NN
cord-015684-q10sx1dm	384	7	levels	level	NNS
cord-015684-q10sx1dm	384	8	and	and	CC
cord-015684-q10sx1dm	384	9	LDL	ldl	NN
cord-015684-q10sx1dm	384	10	-	-	HYPH
cord-015684-q10sx1dm	384	11	cholesterol	cholesterol	NN
cord-015684-q10sx1dm	384	12	levels	level	NNS
cord-015684-q10sx1dm	384	13	are	be	VBP
cord-015684-q10sx1dm	384	14	higher	high	JJR
cord-015684-q10sx1dm	384	15	in	in	IN
cord-015684-q10sx1dm	384	16	EMs	EMs	NNP
cord-015684-q10sx1dm	384	17	(	(	-LRB-
cord-015684-q10sx1dm	384	18	with	with	IN
cord-015684-q10sx1dm	384	19	a	a	DT
cord-015684-q10sx1dm	384	20	signifi	signifi	NN
cord-015684-q10sx1dm	384	21	ca	can	MD
cord-015684-q10sx1dm	384	22	nt	not	RB
cord-015684-q10sx1dm	384	23	difference	difference	VB
cord-015684-q10sx1dm	384	24	between	between	IN
cord-015684-q10sx1dm	385	1	*	*	NFP
cord-015684-q10sx1dm	385	2	1/	1/	CD
cord-015684-q10sx1dm	385	3	*	*	NFP
cord-015684-q10sx1dm	385	4	1	1	CD
cord-015684-q10sx1dm	385	5	and	and	CC
cord-015684-q10sx1dm	385	6	*	*	NFP
cord-015684-q10sx1dm	385	7	1/	1/	CD
cord-015684-q10sx1dm	385	8	*	*	NFP
cord-015684-q10sx1dm	385	9	10	10	CD
cord-015684-q10sx1dm	385	10	)	)	-RRB-
cord-015684-q10sx1dm	385	11	,	,	,
cord-015684-q10sx1dm	385	12	intermediate	intermediate	JJ
cord-015684-q10sx1dm	385	13	levels	level	NNS
cord-015684-q10sx1dm	385	14	are	be	VBP
cord-015684-q10sx1dm	385	15	seen	see	VBN
cord-015684-q10sx1dm	385	16	in	in	IN
cord-015684-q10sx1dm	385	17	IMs	IMs	NNP
cord-015684-q10sx1dm	385	18	,	,	,
cord-015684-q10sx1dm	385	19	and	and	CC
cord-015684-q10sx1dm	385	20	much	much	JJ
cord-015684-q10sx1dm	385	21	lower	low	JJR
cord-015684-q10sx1dm	385	22	levels	level	NNS
cord-015684-q10sx1dm	385	23	in	in	IN
cord-015684-q10sx1dm	385	24	PMs	pm	NNS
cord-015684-q10sx1dm	385	25	and	and	CC
cord-015684-q10sx1dm	385	26	UMs	UMs	NNPS
cord-015684-q10sx1dm	385	27	;	;	:
cord-015684-q10sx1dm	385	28	and	and	CC
cord-015684-q10sx1dm	385	29	the	the	DT
cord-015684-q10sx1dm	385	30	opposite	opposite	NN
cord-015684-q10sx1dm	385	31	occurs	occur	VBZ
cord-015684-q10sx1dm	385	32	with	with	IN
cord-015684-q10sx1dm	385	33	HDLcholesterol	HDLcholesterol	NNP
cord-015684-q10sx1dm	385	34	levels	level	NNS
cord-015684-q10sx1dm	385	35	,	,	,
cord-015684-q10sx1dm	385	36	which	which	WDT
cord-015684-q10sx1dm	385	37	on	on	IN
cord-015684-q10sx1dm	385	38	average	average	JJ
cord-015684-q10sx1dm	385	39	appear	appear	VBP
cord-015684-q10sx1dm	385	40	much	much	RB
cord-015684-q10sx1dm	385	41	lower	low	JJR
cord-015684-q10sx1dm	385	42	in	in	IN
cord-015684-q10sx1dm	385	43	EMs	EMs	NNP
cord-015684-q10sx1dm	385	44	than	than	IN
cord-015684-q10sx1dm	385	45	in	in	IN
cord-015684-q10sx1dm	385	46	IMs	IMs	NNP
cord-015684-q10sx1dm	385	47	,	,	,
cord-015684-q10sx1dm	385	48	PMs	PMs	NNPS
cord-015684-q10sx1dm	385	49	,	,	,
cord-015684-q10sx1dm	385	50	and	and	CC
cord-015684-q10sx1dm	385	51	UMs	UMs	NNP
cord-015684-q10sx1dm	385	52	,	,	,
cord-015684-q10sx1dm	385	53	with	with	IN
cord-015684-q10sx1dm	385	54	the	the	DT
cord-015684-q10sx1dm	385	55	highest	high	JJS
cord-015684-q10sx1dm	385	56	levels	level	NNS
cord-015684-q10sx1dm	385	57	detected	detect	VBN
cord-015684-q10sx1dm	385	58	in	in	IN
cord-015684-q10sx1dm	385	59	*	*	NFP
cord-015684-q10sx1dm	385	60	1/	1/	CD
cord-015684-q10sx1dm	385	61	*	*	NFP
cord-015684-q10sx1dm	385	62	3	3	CD
cord-015684-q10sx1dm	385	63	and	and	CC
cord-015684-q10sx1dm	385	64	*	*	NFP
cord-015684-q10sx1dm	385	65	1xN/	1xn/	CD
cord-015684-q10sx1dm	385	66	*	*	NFP
cord-015684-q10sx1dm	385	67	4	4	CD
cord-015684-q10sx1dm	386	1	(	(	-LRB-
cord-015684-q10sx1dm	386	2	Table	table	NN
cord-015684-q10sx1dm	386	3	40	40	CD
cord-015684-q10sx1dm	386	4	.8	.8	CD
cord-015684-q10sx1dm	386	5	)	)	-RRB-
cord-015684-q10sx1dm	386	6	.	.	.
cord-015684-q10sx1dm	387	1	The	the	DT
cord-015684-q10sx1dm	387	2	levels	level	NNS
cord-015684-q10sx1dm	387	3	of	of	IN
cord-015684-q10sx1dm	387	4	triglycerides	triglyceride	NNS
cord-015684-q10sx1dm	387	5	are	be	VBP
cord-015684-q10sx1dm	387	6	very	very	RB
cord-015684-q10sx1dm	387	7	variable	variable	JJ
cord-015684-q10sx1dm	387	8	among	among	IN
cord-015684-q10sx1dm	387	9	different	different	JJ
cord-015684-q10sx1dm	387	10	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	387	11	polymorphisms	polymorphism	NNS
cord-015684-q10sx1dm	387	12	,	,	,
cord-015684-q10sx1dm	387	13	with	with	IN
cord-015684-q10sx1dm	387	14	the	the	DT
cord-015684-q10sx1dm	387	15	highest	high	JJS
cord-015684-q10sx1dm	387	16	levels	level	NNS
cord-015684-q10sx1dm	387	17	present	present	JJ
cord-015684-q10sx1dm	387	18	in	in	IN
cord-015684-q10sx1dm	387	19	IMs	IMs	NNP
cord-015684-q10sx1dm	387	20	(	(	-LRB-
cord-015684-q10sx1dm	388	1	*	*	NFP
cord-015684-q10sx1dm	388	2	4/	4/	CD
cord-015684-q10sx1dm	388	3	*	*	NFP
cord-015684-q10sx1dm	388	4	10	10	CD
cord-015684-q10sx1dm	388	5	vs.	vs.	IN
cord-015684-q10sx1dm	389	1	*	*	NFP
cord-015684-q10sx1dm	389	2	4/	4/	CD
cord-015684-q10sx1dm	389	3	*	*	NFP
cord-015684-q10sx1dm	389	4	5	5	CD
cord-015684-q10sx1dm	389	5	and	and	CC
cord-015684-q10sx1dm	390	1	*	*	NFP
cord-015684-q10sx1dm	390	2	1xN/	1xn/	CD
cord-015684-q10sx1dm	390	3	*	*	SYM
cord-015684-q10sx1dm	390	4	1	1	CD
cord-015684-q10sx1dm	390	5	,	,	,
cord-015684-q10sx1dm	390	6	p	p	NN
cord-015684-q10sx1dm	390	7	<	<	XX
cord-015684-q10sx1dm	390	8	0.02	0.02	CD
cord-015684-q10sx1dm	390	9	)	)	-RRB-
cord-015684-q10sx1dm	390	10	.	.	.
cord-015684-q10sx1dm	391	1	These	these	DT
cord-015684-q10sx1dm	391	2	data	datum	NNS
cord-015684-q10sx1dm	391	3	clearly	clearly	RB
cord-015684-q10sx1dm	391	4	indicate	indicate	VBP
cord-015684-q10sx1dm	391	5	that	that	IN
cord-015684-q10sx1dm	391	6	lipid	lipid	NN
cord-015684-q10sx1dm	391	7	metabolism	metabolism	NN
cord-015684-q10sx1dm	391	8	can	can	MD
cord-015684-q10sx1dm	391	9	be	be	VB
cord-015684-q10sx1dm	391	10	infl	infl	NN
cord-015684-q10sx1dm	391	11	uenced	uence	VBN
cord-015684-q10sx1dm	391	12	by	by	IN
cord-015684-q10sx1dm	391	13	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	391	14	variants	variant	NNS
cord-015684-q10sx1dm	391	15	or	or	CC
cord-015684-q10sx1dm	391	16	that	that	IN
cord-015684-q10sx1dm	391	17	specifi	specifi	NNP
cord-015684-q10sx1dm	391	18	c	c	NN
cord-015684-q10sx1dm	391	19	phenotypes	phenotype	NNS
cord-015684-q10sx1dm	391	20	determined	determine	VBN
cord-015684-q10sx1dm	391	21	by	by	IN
cord-015684-q10sx1dm	391	22	multiple	multiple	JJ
cord-015684-q10sx1dm	391	23	lipid	lipid	NN
cord-015684-q10sx1dm	391	24	-	-	HYPH
cord-015684-q10sx1dm	391	25	related	relate	VBN
cord-015684-q10sx1dm	391	26	genomic	genomic	JJ
cord-015684-q10sx1dm	391	27	clusters	cluster	NNS
cord-015684-q10sx1dm	391	28	are	be	VBP
cord-015684-q10sx1dm	391	29	necessary	necessary	JJ
cord-015684-q10sx1dm	391	30	to	to	TO
cord-015684-q10sx1dm	391	31	confer	confer	VB
cord-015684-q10sx1dm	391	32	the	the	DT
cord-015684-q10sx1dm	391	33	character	character	NN
cord-015684-q10sx1dm	391	34	of	of	IN
cord-015684-q10sx1dm	391	35	EMs	EMs	NNP
cord-015684-q10sx1dm	391	36	and	and	CC
cord-015684-q10sx1dm	391	37	IMs	IMs	NNP
cord-015684-q10sx1dm	391	38	.	.	.
cord-015684-q10sx1dm	392	1	Other	other	JJ
cord-015684-q10sx1dm	392	2	possibility	possibility	NN
cord-015684-q10sx1dm	392	3	might	may	MD
cord-015684-q10sx1dm	392	4	be	be	VB
cord-015684-q10sx1dm	392	5	that	that	IN
cord-015684-q10sx1dm	392	6	some	some	DT
cord-015684-q10sx1dm	392	7	lipid	lipid	NN
cord-015684-q10sx1dm	392	8	metabolism	metabolism	NN
cord-015684-q10sx1dm	392	9	genotypes	genotype	NNS
cord-015684-q10sx1dm	392	10	interact	interact	VBP
cord-015684-q10sx1dm	392	11	with	with	IN
cord-015684-q10sx1dm	392	12	CYP2D6-related	cyp2d6-related	JJ
cord-015684-q10sx1dm	392	13	enzyme	enzyme	NN
cord-015684-q10sx1dm	392	14	products	product	NNS
cord-015684-q10sx1dm	392	15	leading	lead	VBG
cord-015684-q10sx1dm	392	16	to	to	IN
cord-015684-q10sx1dm	392	17	defi	defi	NNP
cord-015684-q10sx1dm	392	18	ne	ne	NNP
cord-015684-q10sx1dm	392	19	the	the	DT
cord-015684-q10sx1dm	392	20	pheno	pheno	NNP
cord-015684-q10sx1dm	392	21	-	-	HYPH
cord-015684-q10sx1dm	392	22	genotype	genotype	NNP
cord-015684-q10sx1dm	392	23	of	of	IN
cord-015684-q10sx1dm	392	24	PMs	pm	NNS
cord-015684-q10sx1dm	392	25	and	and	CC
cord-015684-q10sx1dm	392	26	UMs	um	NNS
cord-015684-q10sx1dm	392	27	.	.	.
cord-015684-q10sx1dm	393	1	No	no	DT
cord-015684-q10sx1dm	393	2	signifi	signifi	NN
cord-015684-q10sx1dm	393	3	ca	can	MD
cord-015684-q10sx1dm	393	4	nt	not	RB
cord-015684-q10sx1dm	393	5	changes	change	NNS
cord-015684-q10sx1dm	393	6	in	in	IN
cord-015684-q10sx1dm	393	7	blood	blood	NN
cord-015684-q10sx1dm	393	8	pressure	pressure	NN
cord-015684-q10sx1dm	393	9	values	value	NNS
cord-015684-q10sx1dm	393	10	have	have	VBP
cord-015684-q10sx1dm	393	11	been	be	VBN
cord-015684-q10sx1dm	393	12	found	find	VBN
cord-015684-q10sx1dm	393	13	among	among	IN
cord-015684-q10sx1dm	393	14	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	393	15	genotypes	genotype	NNS
cord-015684-q10sx1dm	393	16	;	;	:
cord-015684-q10sx1dm	393	17	however	however	RB
cord-015684-q10sx1dm	393	18	,	,	,
cord-015684-q10sx1dm	393	19	important	important	JJ
cord-015684-q10sx1dm	393	20	differences	difference	NNS
cord-015684-q10sx1dm	393	21	became	become	VBD
cord-015684-q10sx1dm	393	22	apparent	apparent	JJ
cord-015684-q10sx1dm	393	23	in	in	IN
cord-015684-q10sx1dm	393	24	brain	brain	NN
cord-015684-q10sx1dm	393	25	cerebrovascular	cerebrovascular	JJ
cord-015684-q10sx1dm	393	26	hemodynamics	hemodynamic	NNS
cord-015684-q10sx1dm	393	27	(	(	-LRB-
cord-015684-q10sx1dm	393	28	Table	table	NN
cord-015684-q10sx1dm	393	29	40	40	CD
cord-015684-q10sx1dm	393	30	.9	.9	CD
cord-015684-q10sx1dm	393	31	)	)	-RRB-
cord-015684-q10sx1dm	393	32	.	.	.
cord-015684-q10sx1dm	394	1	In	in	IN
cord-015684-q10sx1dm	394	2	general	general	JJ
cord-015684-q10sx1dm	394	3	terms	term	NNS
cord-015684-q10sx1dm	394	4	,	,	,
cord-015684-q10sx1dm	394	5	the	the	DT
cord-015684-q10sx1dm	394	6	best	good	JJS
cord-015684-q10sx1dm	394	7	(	(	-LRB-
cord-015684-q10sx1dm	394	8	2	2	CD
cord-015684-q10sx1dm	394	9	)	)	-RRB-
cord-015684-q10sx1dm	394	10	0.88	0.88	CD
cord-015684-q10sx1dm	394	11	±	±	CD
cord-015684-q10sx1dm	395	1	0.07	0.07	CD
cord-015684-q10sx1dm	395	2	(	(	-LRB-
cord-015684-q10sx1dm	395	3	6	6	CD
cord-015684-q10sx1dm	395	4	)	)	-RRB-
cord-015684-q10sx1dm	395	5	0.56	0.56	CD
cord-015684-q10sx1dm	395	6	±	±	CD
cord-015684-q10sx1dm	395	7	0.02	0.02	CD
cord-015684-q10sx1dm	396	1	(	(	-LRB-
cord-015684-q10sx1dm	396	2	LDL	ldl	NN
cord-015684-q10sx1dm	396	3	-	-	HYPH
cord-015684-q10sx1dm	396	4	cholesterol	cholesterol	NN
cord-015684-q10sx1dm	396	5	levels	level	NNS
cord-015684-q10sx1dm	396	6	,	,	,
cord-015684-q10sx1dm	396	7	than	than	IN
cord-015684-q10sx1dm	396	8	in	in	IN
cord-015684-q10sx1dm	396	9	IMs	IMs	NNP
cord-015684-q10sx1dm	396	10	(	(	-LRB-
cord-015684-q10sx1dm	396	11	*	*	NFP
cord-015684-q10sx1dm	396	12	4/	4/	CD
cord-015684-q10sx1dm	396	13	*	*	NFP
cord-015684-q10sx1dm	396	14	10	10	CD
cord-015684-q10sx1dm	396	15	,	,	,
cord-015684-q10sx1dm	396	16	p	p	NN
cord-015684-q10sx1dm	396	17	<	<	XX
cord-015684-q10sx1dm	396	18	0.05	0.05	CD
cord-015684-q10sx1dm	396	19	)	)	-RRB-
cord-015684-q10sx1dm	396	20	;	;	:
cord-015684-q10sx1dm	396	21	and	and	CC
cord-015684-q10sx1dm	396	22	diastolic	diastolic	JJ
cord-015684-q10sx1dm	396	23	velocities	velocity	NNS
cord-015684-q10sx1dm	396	24	(	(	-LRB-
cord-015684-q10sx1dm	396	25	Dv	Dv	NNP
cord-015684-q10sx1dm	396	26	)	)	-RRB-
cord-015684-q10sx1dm	396	27	also	also	RB
cord-015684-q10sx1dm	396	28	tend	tend	VBP
cord-015684-q10sx1dm	396	29	to	to	TO
cord-015684-q10sx1dm	396	30	be	be	VB
cord-015684-q10sx1dm	396	31	much	much	RB
cord-015684-q10sx1dm	396	32	lower	low	JJR
cord-015684-q10sx1dm	396	33	in	in	IN
cord-015684-q10sx1dm	396	34	*	*	NFP
cord-015684-q10sx1dm	396	35	1/	1/	CD
cord-015684-q10sx1dm	396	36	*	*	NFP
cord-015684-q10sx1dm	396	37	10	10	CD
cord-015684-q10sx1dm	396	38	and	and	CC
cord-015684-q10sx1dm	396	39	especially	especially	RB
cord-015684-q10sx1dm	396	40	in	in	IN
cord-015684-q10sx1dm	396	41	PMs	PMs	NNP
cord-015684-q10sx1dm	396	42	(	(	-LRB-
cord-015684-q10sx1dm	396	43	*	*	NFP
cord-015684-q10sx1dm	396	44	4/	4/	CD
cord-015684-q10sx1dm	396	45	*	*	NFP
cord-015684-q10sx1dm	396	46	4	4	CD
cord-015684-q10sx1dm	396	47	)	)	-RRB-
cord-015684-q10sx1dm	396	48	and	and	CC
cord-015684-q10sx1dm	396	49	UMs	UMs	NNPS
cord-015684-q10sx1dm	396	50	(	(	-LRB-
cord-015684-q10sx1dm	396	51	*	*	NFP
cord-015684-q10sx1dm	396	52	1xN/	1xn/	CD
cord-015684-q10sx1dm	396	53	*	*	NFP
cord-015684-q10sx1dm	396	54	4	4	CD
cord-015684-q10sx1dm	396	55	)	)	-RRB-
cord-015684-q10sx1dm	396	56	,	,	,
cord-015684-q10sx1dm	396	57	whereas	whereas	IN
cord-015684-q10sx1dm	396	58	the	the	DT
cord-015684-q10sx1dm	396	59	best	good	JJS
cord-015684-q10sx1dm	396	60	Dv	Dv	NNP
cord-015684-q10sx1dm	396	61	is	be	VBZ
cord-015684-q10sx1dm	396	62	measured	measure	VBN
cord-015684-q10sx1dm	396	63	in	in	IN
cord-015684-q10sx1dm	396	64	*	*	NFP
cord-015684-q10sx1dm	396	65	1/	1/	CD
cord-015684-q10sx1dm	396	66	*	*	NFP
cord-015684-q10sx1dm	396	67	5	5	CD
cord-015684-q10sx1dm	396	68	IMs	im	NNS
cord-015684-q10sx1dm	396	69	.	.	.
cord-015684-q10sx1dm	397	1	More	more	RBR
cord-015684-q10sx1dm	397	2	striking	striking	JJ
cord-015684-q10sx1dm	397	3	are	be	VBP
cord-015684-q10sx1dm	397	4	the	the	DT
cord-015684-q10sx1dm	397	5	results	result	NNS
cord-015684-q10sx1dm	397	6	of	of	IN
cord-015684-q10sx1dm	397	7	both	both	CC
cord-015684-q10sx1dm	397	8	the	the	DT
cord-015684-q10sx1dm	397	9	pulsatility	pulsatility	NN
cord-015684-q10sx1dm	397	10	index	index	NN
cord-015684-q10sx1dm	397	11	(	(	-LRB-
cord-015684-q10sx1dm	397	12	PI	pi	NN
cord-015684-q10sx1dm	397	13	=	=	NFP
cord-015684-q10sx1dm	397	14	(	(	-LRB-
cord-015684-q10sx1dm	397	15	Sv	Sv	NNP
cord-015684-q10sx1dm	397	16	-	-	HYPH
cord-015684-q10sx1dm	397	17	Dv)/Mv	Dv)/Mv	NNP
cord-015684-q10sx1dm	397	18	)	)	-RRB-
cord-015684-q10sx1dm	397	19	and	and	CC
cord-015684-q10sx1dm	397	20	resistance	resistance	NN
cord-015684-q10sx1dm	397	21	index	index	NN
cord-015684-q10sx1dm	397	22	(	(	-LRB-
cord-015684-q10sx1dm	397	23	RI	RI	NNP
cord-015684-q10sx1dm	397	24	=	=	NFP
cord-015684-q10sx1dm	398	1	(	(	-LRB-
cord-015684-q10sx1dm	398	2	Sv	Sv	NNP
cord-015684-q10sx1dm	398	3	-	-	HYPH
cord-015684-q10sx1dm	398	4	Dv)/Sv	Dv)/Sv	NNP
cord-015684-q10sx1dm	398	5	)	)	-RRB-
cord-015684-q10sx1dm	398	6	,	,	,
cord-015684-q10sx1dm	398	7	which	which	WDT
cord-015684-q10sx1dm	398	8	are	be	VBP
cord-015684-q10sx1dm	398	9	worse	bad	JJR
cord-015684-q10sx1dm	398	10	in	in	IN
cord-015684-q10sx1dm	398	11	IMs	IMs	NNP
cord-015684-q10sx1dm	398	12	and	and	CC
cord-015684-q10sx1dm	398	13	PMs	PMs	NNPS
cord-015684-q10sx1dm	398	14	than	than	IN
cord-015684-q10sx1dm	398	15	in	in	IN
cord-015684-q10sx1dm	398	16	EMs	EMs	NNP
cord-015684-q10sx1dm	398	17	and	and	CC
cord-015684-q10sx1dm	398	18	UMs	UMs	NNPS
cord-015684-q10sx1dm	398	19	(	(	-LRB-
cord-015684-q10sx1dm	398	20	Table	table	NN
cord-015684-q10sx1dm	398	21	40	40	CD
cord-015684-q10sx1dm	398	22	.9	.9	CD
cord-015684-q10sx1dm	398	23	)	)	-RRB-
cord-015684-q10sx1dm	398	24	.	.	.
cord-015684-q10sx1dm	399	1	These	these	DT
cord-015684-q10sx1dm	399	2	data	datum	NNS
cord-015684-q10sx1dm	399	3	taken	take	VBN
cord-015684-q10sx1dm	399	4	together	together	RB
cord-015684-q10sx1dm	399	5	seem	seem	VBP
cord-015684-q10sx1dm	399	6	to	to	TO
cord-015684-q10sx1dm	399	7	indicate	indicate	VB
cord-015684-q10sx1dm	399	8	that	that	IN
cord-015684-q10sx1dm	399	9	CYP2D6-related	CYP2D6-related	NNP
cord-015684-q10sx1dm	399	10	AD	ad	NN
cord-015684-q10sx1dm	399	11	PMs	pm	NNS
cord-015684-q10sx1dm	399	12	exhibit	exhibit	VBP
cord-015684-q10sx1dm	399	13	a	a	DT
cord-015684-q10sx1dm	399	14	poorer	poor	JJR
cord-015684-q10sx1dm	399	15	cerebrovascular	cerebrovascular	JJ
cord-015684-q10sx1dm	399	16	function	function	NN
cord-015684-q10sx1dm	399	17	which	which	WDT
cord-015684-q10sx1dm	399	18	might	may	MD
cord-015684-q10sx1dm	399	19	affect	affect	VB
cord-015684-q10sx1dm	399	20	drug	drug	NN
cord-015684-q10sx1dm	399	21	penetration	penetration	NN
cord-015684-q10sx1dm	399	22	in	in	IN
cord-015684-q10sx1dm	399	23	the	the	DT
cord-015684-q10sx1dm	399	24	brain	brain	NN
cord-015684-q10sx1dm	399	25	with	with	IN
cord-015684-q10sx1dm	399	26	the	the	DT
cord-015684-q10sx1dm	399	27	consequent	consequent	JJ
cord-015684-q10sx1dm	399	28	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	399	29	implications	implication	NNS
cord-015684-q10sx1dm	399	30	.	.	.
cord-015684-q10sx1dm	400	1	[	[	-LRB-
cord-015684-q10sx1dm	400	2	16	16	CD
cord-015684-q10sx1dm	400	3	]	]	-RRB-
cord-015684-q10sx1dm	400	4	[	[	-LRB-
cord-015684-q10sx1dm	400	5	17	17	CD
cord-015684-q10sx1dm	400	6	]	]	-RRB-
cord-015684-q10sx1dm	400	7	[	[	-LRB-
cord-015684-q10sx1dm	400	8	18	18	CD
cord-015684-q10sx1dm	400	9	]	]	-RRB-
cord-015684-q10sx1dm	400	10	[	[	-LRB-
cord-015684-q10sx1dm	400	11	19	19	CD
cord-015684-q10sx1dm	400	12	]	]	-RRB-
cord-015684-q10sx1dm	401	1	[	[	-LRB-
cord-015684-q10sx1dm	401	2	20	20	CD
cord-015684-q10sx1dm	401	3	]	]	-RRB-
cord-015684-q10sx1dm	401	4	[	[	-LRB-
cord-015684-q10sx1dm	401	5	74	74	CD
cord-015684-q10sx1dm	401	6	]	]	-RRB-
cord-015684-q10sx1dm	402	1	[	[	-LRB-
cord-015684-q10sx1dm	402	2	75	75	CD
cord-015684-q10sx1dm	402	3	]	]	-RRB-
cord-015684-q10sx1dm	402	4	[	[	-LRB-
cord-015684-q10sx1dm	402	5	76	76	CD
cord-015684-q10sx1dm	402	6	]	]	-RRB-
cord-015684-q10sx1dm	403	1	[	[	-LRB-
cord-015684-q10sx1dm	403	2	77	77	CD
cord-015684-q10sx1dm	403	3	]	]	-RRB-
cord-015684-q10sx1dm	403	4	 	 	_SP
cord-015684-q10sx1dm	404	1	Some	some	DT
cord-015684-q10sx1dm	404	2	conventional	conventional	JJ
cord-015684-q10sx1dm	404	3	anti	anti	JJ
cord-015684-q10sx1dm	404	4	-	-	JJ
cord-015684-q10sx1dm	404	5	dementia	dementia	JJ
cord-015684-q10sx1dm	404	6	drugs	drug	NNS
cord-015684-q10sx1dm	404	7	(	(	-LRB-
cord-015684-q10sx1dm	404	8	tacrine	tacrine	NNP
cord-015684-q10sx1dm	404	9	,	,	,
cord-015684-q10sx1dm	404	10	donepezil	donepezil	NNP
cord-015684-q10sx1dm	404	11	,	,	,
cord-015684-q10sx1dm	404	12	galantamine	galantamine	NNP
cord-015684-q10sx1dm	404	13	)	)	-RRB-
cord-015684-q10sx1dm	404	14	are	be	VBP
cord-015684-q10sx1dm	404	15	metabolized	metabolize	VBN
cord-015684-q10sx1dm	404	16	via	via	IN
cord-015684-q10sx1dm	404	17	CYP	CYP	NNP
cord-015684-q10sx1dm	404	18	-	-	HYPH
cord-015684-q10sx1dm	404	19	related	relate	VBN
cord-015684-q10sx1dm	404	20	enzymes	enzyme	NNS
cord-015684-q10sx1dm	404	21	,	,	,
cord-015684-q10sx1dm	404	22	especially	especially	RB
cord-015684-q10sx1dm	404	23	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	404	24	,	,	,
cord-015684-q10sx1dm	404	25	CYP3A4	CYP3A4	NNP
cord-015684-q10sx1dm	404	26	,	,	,
cord-015684-q10sx1dm	404	27	and	and	CC
cord-015684-q10sx1dm	404	28	CYP1A2	CYP1A2	NNP
cord-015684-q10sx1dm	404	29	,	,	,
cord-015684-q10sx1dm	404	30	and	and	CC
cord-015684-q10sx1dm	404	31	polymorphic	polymorphic	JJ
cord-015684-q10sx1dm	404	32	variants	variant	NNS
cord-015684-q10sx1dm	404	33	of	of	IN
cord-015684-q10sx1dm	404	34	the	the	DT
cord-015684-q10sx1dm	404	35	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	404	36	gene	gene	NN
cord-015684-q10sx1dm	404	37	can	can	MD
cord-015684-q10sx1dm	404	38	affect	affect	VB
cord-015684-q10sx1dm	404	39	the	the	DT
cord-015684-q10sx1dm	404	40	liver	liver	NN
cord-015684-q10sx1dm	404	41	metabolism	metabolism	NN
cord-015684-q10sx1dm	404	42	,	,	,
cord-015684-q10sx1dm	404	43	safety	safety	NN
cord-015684-q10sx1dm	404	44	and	and	CC
cord-015684-q10sx1dm	404	45	effi	effi	NNP
cord-015684-q10sx1dm	404	46	cacy	cacy	NNP
cord-015684-q10sx1dm	404	47	of	of	IN
cord-015684-q10sx1dm	404	48	some	some	DT
cord-015684-q10sx1dm	404	49	cholinesterase	cholinesterase	NN
cord-015684-q10sx1dm	404	50	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	404	51	.	.	.
cord-015684-q10sx1dm	405	1	107	107	CD
cord-015684-q10sx1dm	405	2	,	,	,
cord-015684-q10sx1dm	405	3	108	108	CD
cord-015684-q10sx1dm	405	4	In	in	IN
cord-015684-q10sx1dm	405	5	order	order	NN
cord-015684-q10sx1dm	405	6	to	to	TO
cord-015684-q10sx1dm	405	7	elucidate	elucidate	VB
cord-015684-q10sx1dm	405	8	whether	whether	IN
cord-015684-q10sx1dm	405	9	or	or	CC
cord-015684-q10sx1dm	405	10	not	not	RB
cord-015684-q10sx1dm	405	11	CYP2D6-related	cyp2d6-relate	VBN
cord-015684-q10sx1dm	405	12	variants	variant	NNS
cord-015684-q10sx1dm	405	13	may	may	MD
cord-015684-q10sx1dm	405	14	infl	infl	VB
cord-015684-q10sx1dm	405	15	uence	uence	NN
cord-015684-q10sx1dm	405	16	transaminase	transaminase	NN
cord-015684-q10sx1dm	405	17	activity	activity	NN
cord-015684-q10sx1dm	405	18	,	,	,
cord-015684-q10sx1dm	405	19	we	-PRON-	PRP
cord-015684-q10sx1dm	405	20	have	have	VBP
cord-015684-q10sx1dm	405	21	studied	study	VBN
cord-015684-q10sx1dm	405	22	the	the	DT
cord-015684-q10sx1dm	405	23	association	association	NN
cord-015684-q10sx1dm	405	24	of	of	IN
cord-015684-q10sx1dm	405	25	GOT	GOT	NNP
cord-015684-q10sx1dm	405	26	,	,	,
cord-015684-q10sx1dm	405	27	GPT	GPT	NNP
cord-015684-q10sx1dm	405	28	,	,	,
cord-015684-q10sx1dm	405	29	and	and	CC
cord-015684-q10sx1dm	405	30	GGT	ggt	NN
cord-015684-q10sx1dm	405	31	activity	activity	NN
cord-015684-q10sx1dm	405	32	with	with	IN
cord-015684-q10sx1dm	405	33	the	the	DT
cord-015684-q10sx1dm	405	34	most	most	RBS
cord-015684-q10sx1dm	405	35	prevalent	prevalent	JJ
cord-015684-q10sx1dm	405	36	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	405	37	genotypes	genotype	NNS
cord-015684-q10sx1dm	405	38	in	in	IN
cord-015684-q10sx1dm	405	39	AD	ad	NN
cord-015684-q10sx1dm	405	40	(	(	-LRB-
cord-015684-q10sx1dm	405	41	Table	table	NN
cord-015684-q10sx1dm	405	42	40	40	CD
cord-015684-q10sx1dm	405	43	.10	.10	CD
cord-015684-q10sx1dm	405	44	)	)	-RRB-
cord-015684-q10sx1dm	405	45	.	.	.
cord-015684-q10sx1dm	406	1	Globally	globally	RB
cord-015684-q10sx1dm	406	2	,	,	,
cord-015684-q10sx1dm	406	3	UMs	UMs	NNPS
cord-015684-q10sx1dm	406	4	and	and	CC
cord-015684-q10sx1dm	406	5	PMs	pm	NNS
cord-015684-q10sx1dm	406	6	tend	tend	VBP
cord-015684-q10sx1dm	406	7	to	to	TO
cord-015684-q10sx1dm	406	8	show	show	VB
cord-015684-q10sx1dm	406	9	the	the	DT
cord-015684-q10sx1dm	406	10	highest	high	JJS
cord-015684-q10sx1dm	406	11	GOT	got	NN
cord-015684-q10sx1dm	406	12	activity	activity	NN
cord-015684-q10sx1dm	406	13	and	and	CC
cord-015684-q10sx1dm	406	14	IMs	IMs	NNP
cord-015684-q10sx1dm	406	15	the	the	DT
cord-015684-q10sx1dm	406	16	lowest	low	JJS
cord-015684-q10sx1dm	406	17	.	.	.
cord-015684-q10sx1dm	407	1	Signifi	Signifi	NNP
cord-015684-q10sx1dm	407	2	ca	can	MD
cord-015684-q10sx1dm	407	3	nt	not	RB
cord-015684-q10sx1dm	407	4	differences	difference	NNS
cord-015684-q10sx1dm	407	5	appear	appear	VB
cord-015684-q10sx1dm	407	6	among	among	IN
cord-015684-q10sx1dm	407	7	different	different	JJ
cord-015684-q10sx1dm	407	8	IM	im	NN
cord-015684-q10sx1dm	407	9	-	-	HYPH
cord-015684-q10sx1dm	407	10	related	relate	VBN
cord-015684-q10sx1dm	407	11	genotypes	genotype	NNS
cord-015684-q10sx1dm	407	12	.	.	.
cord-015684-q10sx1dm	408	1	The	the	DT
cord-015684-q10sx1dm	408	2	*	*	NFP
cord-015684-q10sx1dm	408	3	10/	10/	CD
cord-015684-q10sx1dm	408	4	*	*	NFP
cord-015684-q10sx1dm	408	5	10	10	CD
cord-015684-q10sx1dm	408	6	genotype	genotype	NN
cord-015684-q10sx1dm	408	7	exhibited	exhibit	VBD
cord-015684-q10sx1dm	408	8	the	the	DT
cord-015684-q10sx1dm	408	9	lowest	low	JJS
cord-015684-q10sx1dm	408	10	GOT	got	NN
cord-015684-q10sx1dm	408	11	activity	activity	NN
cord-015684-q10sx1dm	408	12	with	with	IN
cord-015684-q10sx1dm	408	13	marked	marked	JJ
cord-015684-q10sx1dm	408	14	differences	difference	NNS
cord-015684-q10sx1dm	408	15	as	as	IN
cord-015684-q10sx1dm	408	16	compared	compare	VBN
cord-015684-q10sx1dm	408	17	to	to	IN
cord-015684-q10sx1dm	408	18	UMs	UMs	NNP
cord-015684-q10sx1dm	408	19	(	(	-LRB-
cord-015684-q10sx1dm	408	20	p	p	NN
cord-015684-q10sx1dm	408	21	<	<	XX
cord-015684-q10sx1dm	408	22	0.05	0.05	CD
cord-015684-q10sx1dm	408	23	vs.	vs.	FW
cord-015684-q10sx1dm	408	24	*	*	NFP
cord-015684-q10sx1dm	408	25	1xN/	1xn/	CD
cord-015684-q10sx1dm	408	26	*	*	SYM
cord-015684-q10sx1dm	408	27	1	1	CD
cord-015684-q10sx1dm	408	28	;	;	:
cord-015684-q10sx1dm	408	29	p	p	NN
cord-015684-q10sx1dm	408	30	<	<	XX
cord-015684-q10sx1dm	408	31	0.05	0.05	CD
cord-015684-q10sx1dm	408	32	vs.	vs.	FW
cord-015684-q10sx1dm	408	33	*	*	NFP
cord-015684-q10sx1dm	408	34	1xN/	1xn/	CD
cord-015684-q10sx1dm	408	35	*	*	NFP
cord-015684-q10sx1dm	408	36	4	4	CD
cord-015684-q10sx1dm	408	37	)	)	-RRB-
cord-015684-q10sx1dm	408	38	.	.	.
cord-015684-q10sx1dm	409	1	GPT	gpt	NN
cord-015684-q10sx1dm	409	2	activity	activity	NN
cord-015684-q10sx1dm	409	3	was	be	VBD
cord-015684-q10sx1dm	409	4	signifi	signifi	NNP
cord-015684-q10sx1dm	409	5	cantly	cantly	RB
cord-015684-q10sx1dm	409	6	higher	higher	RBR
cord-015684-q10sx1dm	409	7	in	in	IN
cord-015684-q10sx1dm	409	8	PMs	PMs	NNP
cord-015684-q10sx1dm	409	9	(	(	-LRB-
cord-015684-q10sx1dm	409	10	*	*	NFP
cord-015684-q10sx1dm	409	11	4/	4/	CD
cord-015684-q10sx1dm	409	12	*	*	NFP
cord-015684-q10sx1dm	409	13	4	4	CD
cord-015684-q10sx1dm	409	14	)	)	-RRB-
cord-015684-q10sx1dm	409	15	than	than	IN
cord-015684-q10sx1dm	409	16	in	in	IN
cord-015684-q10sx1dm	409	17	EMs	EMs	NNP
cord-015684-q10sx1dm	409	18	(	(	-LRB-
cord-015684-q10sx1dm	409	19	*	*	NFP
cord-015684-q10sx1dm	409	20	1/	1/	CD
cord-015684-q10sx1dm	409	21	*	*	NFP
cord-015684-q10sx1dm	409	22	10	10	CD
cord-015684-q10sx1dm	409	23	,	,	,
cord-015684-q10sx1dm	409	24	p	p	NN
cord-015684-q10sx1dm	409	25	<	<	XX
cord-015684-q10sx1dm	409	26	0.05	0.05	CD
cord-015684-q10sx1dm	409	27	)	)	-RRB-
cord-015684-q10sx1dm	409	28	or	or	CC
cord-015684-q10sx1dm	409	29	IMs	IMs	NNP
cord-015684-q10sx1dm	409	30	(	(	-LRB-
cord-015684-q10sx1dm	409	31	*	*	NFP
cord-015684-q10sx1dm	409	32	1/	1/	CD
cord-015684-q10sx1dm	409	33	*	*	NFP
cord-015684-q10sx1dm	409	34	4	4	CD
cord-015684-q10sx1dm	409	35	,	,	,
cord-015684-q10sx1dm	409	36	*	*	NFP
cord-015684-q10sx1dm	409	37	1/	1/	CD
cord-015684-q10sx1dm	409	38	*	*	NFP
cord-015684-q10sx1dm	409	39	5	5	CD
cord-015684-q10sx1dm	409	40	,	,	,
cord-015684-q10sx1dm	409	41	p	p	NN
cord-015684-q10sx1dm	409	42	<	<	XX
cord-015684-q10sx1dm	409	43	0.05	0.05	CD
cord-015684-q10sx1dm	409	44	)	)	-RRB-
cord-015684-q10sx1dm	409	45	.	.	.
cord-015684-q10sx1dm	410	1	The	the	DT
cord-015684-q10sx1dm	410	2	lowest	low	JJS
cord-015684-q10sx1dm	410	3	GPT	gpt	NN
cord-015684-q10sx1dm	410	4	activity	activity	NN
cord-015684-q10sx1dm	410	5	was	be	VBD
cord-015684-q10sx1dm	410	6	found	find	VBN
cord-015684-q10sx1dm	410	7	in	in	IN
cord-015684-q10sx1dm	410	8	EMs	EMs	NNP
cord-015684-q10sx1dm	410	9	and	and	CC
cord-015684-q10sx1dm	410	10	IMs	IMs	NNP
cord-015684-q10sx1dm	410	11	.	.	.
cord-015684-q10sx1dm	411	1	Striking	strike	VBG
cord-015684-q10sx1dm	411	2	differences	difference	NNS
cord-015684-q10sx1dm	411	3	have	have	VBP
cord-015684-q10sx1dm	411	4	been	be	VBN
cord-015684-q10sx1dm	411	5	found	find	VBN
cord-015684-q10sx1dm	411	6	in	in	IN
cord-015684-q10sx1dm	411	7	GGT	ggt	NN
cord-015684-q10sx1dm	411	8	activity	activity	NN
cord-015684-q10sx1dm	411	9	between	between	IN
cord-015684-q10sx1dm	411	10	PMs	pm	NNS
cord-015684-q10sx1dm	411	11	(	(	-LRB-
cord-015684-q10sx1dm	411	12	*	*	NFP
cord-015684-q10sx1dm	411	13	4/	4/	CD
cord-015684-q10sx1dm	411	14	*	*	NFP
cord-015684-q10sx1dm	411	15	4	4	CD
cord-015684-q10sx1dm	411	16	)	)	-RRB-
cord-015684-q10sx1dm	411	17	,	,	,
cord-015684-q10sx1dm	411	18	which	which	WDT
cord-015684-q10sx1dm	411	19	showed	show	VBD
cord-015684-q10sx1dm	411	20	the	the	DT
cord-015684-q10sx1dm	411	21	highest	high	JJS
cord-015684-q10sx1dm	411	22	levels	level	NNS
cord-015684-q10sx1dm	411	23	,	,	,
cord-015684-q10sx1dm	411	24	and	and	CC
cord-015684-q10sx1dm	411	25	EMs	EMs	NNP
cord-015684-q10sx1dm	411	26	(	(	-LRB-
cord-015684-q10sx1dm	411	27	*	*	NFP
cord-015684-q10sx1dm	411	28	1/	1/	CD
cord-015684-q10sx1dm	411	29	*	*	SYM
cord-015684-q10sx1dm	411	30	1	1	CD
cord-015684-q10sx1dm	411	31	,	,	,
cord-015684-q10sx1dm	411	32	p	p	NN
cord-015684-q10sx1dm	411	33	<	<	XX
cord-015684-q10sx1dm	411	34	0.05	0.05	CD
cord-015684-q10sx1dm	411	35	;	;	:
cord-015684-q10sx1dm	411	36	*	*	NFP
cord-015684-q10sx1dm	411	37	1/	1/	CD
cord-015684-q10sx1dm	411	38	*	*	NFP
cord-015684-q10sx1dm	411	39	10	10	CD
cord-015684-q10sx1dm	411	40	,	,	,
cord-015684-q10sx1dm	411	41	p	p	NN
cord-015684-q10sx1dm	411	42	<	<	XX
cord-015684-q10sx1dm	411	43	0.05	0.05	CD
cord-015684-q10sx1dm	411	44	)	)	-RRB-
cord-015684-q10sx1dm	411	45	,	,	,
cord-015684-q10sx1dm	411	46	IMs	IMs	NNP
cord-015684-q10sx1dm	411	47	(	(	-LRB-
cord-015684-q10sx1dm	411	48	*	*	NFP
cord-015684-q10sx1dm	411	49	1/	1/	CD
cord-015684-q10sx1dm	411	50	*	*	NFP
cord-015684-q10sx1dm	411	51	5	5	CD
cord-015684-q10sx1dm	411	52	,	,	,
cord-015684-q10sx1dm	411	53	p	p	NN
cord-015684-q10sx1dm	411	54	<	<	XX
cord-015684-q10sx1dm	411	55	0.05	0.05	CD
cord-015684-q10sx1dm	411	56	)	)	-RRB-
cord-015684-q10sx1dm	411	57	,	,	,
cord-015684-q10sx1dm	411	58	or	or	CC
cord-015684-q10sx1dm	411	59	UMs	UMs	NNPS
cord-015684-q10sx1dm	411	60	(	(	-LRB-
cord-015684-q10sx1dm	411	61	*	*	NFP
cord-015684-q10sx1dm	411	62	1xN/	1xn/	CD
cord-015684-q10sx1dm	411	63	*	*	SYM
cord-015684-q10sx1dm	411	64	1	1	CD
cord-015684-q10sx1dm	411	65	,	,	,
cord-015684-q10sx1dm	411	66	p	p	NN
cord-015684-q10sx1dm	411	67	<	<	XX
cord-015684-q10sx1dm	411	68	0.01	0.01	CD
cord-015684-q10sx1dm	411	69	)	)	-RRB-
cord-015684-q10sx1dm	411	70	)	)	-RRB-
cord-015684-q10sx1dm	412	1	(	(	-LRB-
cord-015684-q10sx1dm	412	2	Table	table	NN
cord-015684-q10sx1dm	412	3	 	 	_SP
cord-015684-q10sx1dm	412	4	40	40	CD
cord-015684-q10sx1dm	412	5	.10	.10	CD
cord-015684-q10sx1dm	412	6	)	)	-RRB-
cord-015684-q10sx1dm	412	7	.	.	.
cord-015684-q10sx1dm	413	1	Interesting	interesting	JJ
cord-015684-q10sx1dm	413	2	enough	enough	RB
cord-015684-q10sx1dm	413	3	,	,	,
cord-015684-q10sx1dm	413	4	the	the	DT
cord-015684-q10sx1dm	413	5	*	*	NFP
cord-015684-q10sx1dm	413	6	10/	10/	CD
cord-015684-q10sx1dm	413	7	*	*	NFP
cord-015684-q10sx1dm	413	8	10	10	CD
cord-015684-q10sx1dm	413	9	genotype	genotype	NN
cord-015684-q10sx1dm	413	10	,	,	,
cord-015684-q10sx1dm	413	11	with	with	IN
cord-015684-q10sx1dm	413	12	the	the	DT
cord-015684-q10sx1dm	413	13	lowest	low	JJS
cord-015684-q10sx1dm	413	14	values	value	NNS
cord-015684-q10sx1dm	413	15	of	of	IN
cord-015684-q10sx1dm	413	16	GOT	GOT	NNP
cord-015684-q10sx1dm	413	17	and	and	CC
cord-015684-q10sx1dm	413	18	GPT	GPT	NNP
cord-015684-q10sx1dm	413	19	,	,	,
cord-015684-q10sx1dm	413	20	exhibited	exhibit	VBD
cord-015684-q10sx1dm	413	21	the	the	DT
cord-015684-q10sx1dm	413	22	second	second	JJ
cord-015684-q10sx1dm	413	23	highest	high	JJS
cord-015684-q10sx1dm	413	24	levels	level	NNS
cord-015684-q10sx1dm	413	25	of	of	IN
cord-015684-q10sx1dm	413	26	GGT	ggt	NN
cord-015684-q10sx1dm	413	27	after	after	IN
cord-015684-q10sx1dm	413	28	*	*	NFP
cord-015684-q10sx1dm	413	29	4/	4/	CD
cord-015684-q10sx1dm	413	30	*	*	NFP
cord-015684-q10sx1dm	413	31	4	4	CD
cord-015684-q10sx1dm	413	32	,	,	,
cord-015684-q10sx1dm	413	33	probably	probably	RB
cord-015684-q10sx1dm	413	34	indicating	indicate	VBG
cord-015684-q10sx1dm	413	35	that	that	IN
cord-015684-q10sx1dm	413	36	CYP2D6-related	cyp2d6-relate	VBN
cord-015684-q10sx1dm	413	37	enzymes	enzyme	NNS
cord-015684-q10sx1dm	413	38	differentially	differentially	RB
cord-015684-q10sx1dm	413	39	regulate	regulate	VBP
cord-015684-q10sx1dm	413	40	drug	drug	NN
cord-015684-q10sx1dm	413	41	metabolism	metabolism	NN
cord-015684-q10sx1dm	413	42	and	and	CC
cord-015684-q10sx1dm	413	43	transaminase	transaminase	NN
cord-015684-q10sx1dm	413	44	activity	activity	NN
cord-015684-q10sx1dm	413	45	in	in	IN
cord-015684-q10sx1dm	413	46	the	the	DT
cord-015684-q10sx1dm	413	47	liver	liver	NN
cord-015684-q10sx1dm	413	48	.	.	.
cord-015684-q10sx1dm	414	1	These	these	DT
cord-015684-q10sx1dm	414	2	results	result	NNS
cord-015684-q10sx1dm	414	3	are	be	VBP
cord-015684-q10sx1dm	414	4	also	also	RB
cord-015684-q10sx1dm	414	5	clear	clear	JJ
cord-015684-q10sx1dm	414	6	in	in	IN
cord-015684-q10sx1dm	414	7	demonstrating	demonstrate	VBG
cord-015684-q10sx1dm	414	8	the	the	DT
cord-015684-q10sx1dm	414	9	direct	direct	JJ
cord-015684-q10sx1dm	414	10	effect	effect	NN
cord-015684-q10sx1dm	414	11	of	of	IN
cord-015684-q10sx1dm	414	12	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	414	13	variants	variant	NNS
cord-015684-q10sx1dm	414	14	on	on	IN
cord-015684-q10sx1dm	414	15	transaminase	transaminase	FW
cord-015684-q10sx1dm	414	16	activity	activity	NN
cord-015684-q10sx1dm	415	1	20,77,109	20,77,109	CD
cord-015684-q10sx1dm	415	2	(	(	-LRB-
cord-015684-q10sx1dm	415	3	Table	table	NN
cord-015684-q10sx1dm	415	4	40	40	CD
cord-015684-q10sx1dm	415	5	.10	.10	CD
cord-015684-q10sx1dm	415	6	)	)	-RRB-
cord-015684-q10sx1dm	415	7	.	.	.
cord-015684-q10sx1dm	416	1	(	(	-LRB-
cord-015684-q10sx1dm	416	2	2	2	CD
cord-015684-q10sx1dm	416	3	)	)	-RRB-
cord-015684-q10sx1dm	416	4	16.28	16.28	CD
cord-015684-q10sx1dm	416	5	±	±	CD
cord-015684-q10sx1dm	416	6	7.40	7.40	CD
cord-015684-q10sx1dm	416	7	(	(	-LRB-
cord-015684-q10sx1dm	416	8	11	11	CD
cord-015684-q10sx1dm	416	9	)	)	-RRB-
cord-015684-q10sx1dm	416	10	18.14	18.14	CD
cord-015684-q10sx1dm	416	11	±	±	CD
cord-015684-q10sx1dm	417	1	6.79	6.79	CD
cord-015684-q10sx1dm	417	2	(	(	-LRB-
cord-015684-q10sx1dm	417	3	17	17	CD
cord-015684-q10sx1dm	417	4	)	)	-RRB-
cord-015684-q10sx1dm	417	5	Intermediate	intermediate	JJ
cord-015684-q10sx1dm	417	6	metabolizers	metabolizer	NNS
cord-015684-q10sx1dm	417	7	*	*	NFP
cord-015684-q10sx1dm	417	8	1/	1/	CD
cord-015684-q10sx1dm	417	9	*	*	NFP
cord-015684-q10sx1dm	417	10	3	3	CD
cord-015684-q10sx1dm	417	11	22.33	22.33	CD
cord-015684-q10sx1dm	417	12	±	±	CD
cord-015684-q10sx1dm	417	13	1.52	1.52	CD
cord-015684-q10sx1dm	417	14	(	(	-LRB-
cord-015684-q10sx1dm	417	15	3	3	CD
cord-015684-q10sx1dm	417	16	,	,	,
cord-015684-q10sx1dm	417	17	4	4	CD
cord-015684-q10sx1dm	417	18	)	)	-RRB-
cord-015684-q10sx1dm	417	19	24.66	24.66	CD
cord-015684-q10sx1dm	417	20	±	±	CD
cord-015684-q10sx1dm	417	21	10	10	CD
cord-015684-q10sx1dm	417	22	.	.	.
cord-015684-q10sx1dm	418	1	59	59	CD
cord-015684-q10sx1dm	418	2	22.00	22.00	CD
cord-015684-q10sx1dm	418	3	±	±	CD
cord-015684-q10sx1dm	418	4	8.71	8.71	CD
cord-015684-q10sx1dm	418	5	*	*	NFP
cord-015684-q10sx1dm	418	6	1/	1/	CD
cord-015684-q10sx1dm	418	7	*	*	NFP
cord-015684-q10sx1dm	418	8	4	4	CD
cord-015684-q10sx1dm	418	9	21.76	21.76	CD
cord-015684-q10sx1dm	418	10	±	±	CD
cord-015684-q10sx1dm	418	11	3.57	3.57	CD
cord-015684-q10sx1dm	418	12	(	(	-LRB-
cord-015684-q10sx1dm	418	13	5	5	CD
cord-015684-q10sx1dm	418	14	,	,	,
cord-015684-q10sx1dm	418	15	6	6	CD
cord-015684-q10sx1dm	418	16	)	)	-RRB-
cord-015684-q10sx1dm	418	17	21.88	21.88	CD
cord-015684-q10sx1dm	418	18	±	±	CD
cord-015684-q10sx1dm	418	19	8.40	8.40	CD
cord-015684-q10sx1dm	418	20	32.23	32.23	CD
cord-015684-q10sx1dm	418	21	±	±	CD
cord-015684-q10sx1dm	418	22	25.53	25.53	CD
cord-015684-q10sx1dm	418	23	*	*	NFP
cord-015684-q10sx1dm	418	24	1/	1/	CD
cord-015684-q10sx1dm	418	25	*	*	NFP
cord-015684-q10sx1dm	418	26	5	5	CD
cord-015684-q10sx1dm	418	27	18.33	18.33	CD
cord-015684-q10sx1dm	418	28	±	±	CD
cord-015684-q10sx1dm	418	29	2.33	2.33	CD
cord-015684-q10sx1dm	418	30	(	(	-LRB-
cord-015684-q10sx1dm	418	31	7	7	CD
cord-015684-q10sx1dm	418	32	,	,	,
cord-015684-q10sx1dm	418	33	8)	8)	NN
cord-015684-q10sx1dm	418	34	16.16	16.16	CD
cord-015684-q10sx1dm	418	35	±	±	CD
cord-015684-q10sx1dm	418	36	5.60	5.60	CD
cord-015684-q10sx1dm	418	37	(	(	-LRB-
cord-015684-q10sx1dm	418	38	12	12	CD
cord-015684-q10sx1dm	418	39	,	,	,
cord-015684-q10sx1dm	418	40	13	13	CD
cord-015684-q10sx1dm	418	41	)	)	-RRB-
cord-015684-q10sx1dm	418	42	18.50	18.50	CD
cord-015684-q10sx1dm	418	43	±	±	CD
cord-015684-q10sx1dm	418	44	6.47	6.47	CD
cord-015684-q10sx1dm	419	1	(	(	-LRB-
cord-015684-q10sx1dm	419	2	 	 	_SP
cord-015684-q10sx1dm	419	3	No	no	DT
cord-015684-q10sx1dm	419	4	clinical	clinical	JJ
cord-015684-q10sx1dm	419	5	trials	trial	NNS
cord-015684-q10sx1dm	419	6	have	have	VBP
cord-015684-q10sx1dm	419	7	been	be	VBN
cord-015684-q10sx1dm	419	8	performed	perform	VBN
cord-015684-q10sx1dm	419	9	to	to	IN
cord-015684-q10sx1dm	419	10	date	date	NN
cord-015684-q10sx1dm	419	11	to	to	TO
cord-015684-q10sx1dm	419	12	elucidate	elucidate	VB
cord-015684-q10sx1dm	419	13	the	the	DT
cord-015684-q10sx1dm	419	14	infl	infl	NN
cord-015684-q10sx1dm	419	15	uence	uence	NN
cord-015684-q10sx1dm	419	16	of	of	IN
cord-015684-q10sx1dm	419	17	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	419	18	variants	variant	NNS
cord-015684-q10sx1dm	419	19	on	on	IN
cord-015684-q10sx1dm	419	20	the	the	DT
cord-015684-q10sx1dm	419	21	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	419	22	outcome	outcome	NN
cord-015684-q10sx1dm	419	23	in	in	IN
cord-015684-q10sx1dm	419	24	AD	ad	NN
cord-015684-q10sx1dm	419	25	in	in	IN
cord-015684-q10sx1dm	419	26	response	response	NN
cord-015684-q10sx1dm	419	27	to	to	IN
cord-015684-q10sx1dm	419	28	cholinesterase	cholinesterase	NN
cord-015684-q10sx1dm	419	29	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	419	30	or	or	CC
cord-015684-q10sx1dm	419	31	other	other	JJ
cord-015684-q10sx1dm	419	32	anti	anti	JJ
cord-015684-q10sx1dm	419	33	-	-	JJ
cord-015684-q10sx1dm	419	34	dementia	dementia	JJ
cord-015684-q10sx1dm	419	35	drugs	drug	NNS
cord-015684-q10sx1dm	419	36	.	.	.
cord-015684-q10sx1dm	420	1	To	to	TO
cord-015684-q10sx1dm	420	2	overcome	overcome	VB
cord-015684-q10sx1dm	420	3	this	this	DT
cord-015684-q10sx1dm	420	4	lack	lack	NN
cord-015684-q10sx1dm	420	5	of	of	IN
cord-015684-q10sx1dm	420	6	pharmacogenetic	pharmacogenetic	JJ
cord-015684-q10sx1dm	420	7	information	information	NN
cord-015684-q10sx1dm	420	8	,	,	,
cord-015684-q10sx1dm	420	9	we	-PRON-	PRP
cord-015684-q10sx1dm	420	10	have	have	VBP
cord-015684-q10sx1dm	420	11	performed	perform	VBN
cord-015684-q10sx1dm	420	12	the	the	DT
cord-015684-q10sx1dm	420	13	fi	fi	NNP
cord-015684-q10sx1dm	420	14	rst	rst	NNP
cord-015684-q10sx1dm	420	15	prospective	prospective	JJ
cord-015684-q10sx1dm	420	16	study	study	NN
cord-015684-q10sx1dm	420	17	in	in	IN
cord-015684-q10sx1dm	420	18	AD	ad	NN
cord-015684-q10sx1dm	420	19	patients	patient	NNS
cord-015684-q10sx1dm	420	20	who	who	WP
cord-015684-q10sx1dm	420	21	received	receive	VBD
cord-015684-q10sx1dm	420	22	a	a	DT
cord-015684-q10sx1dm	420	23	combination	combination	NN
cord-015684-q10sx1dm	420	24	therapy	therapy	NN
cord-015684-q10sx1dm	420	25	with	with	IN
cord-015684-q10sx1dm	420	26	(	(	-LRB-
cord-015684-q10sx1dm	420	27	a	a	LS
cord-015684-q10sx1dm	420	28	)	)	-RRB-
cord-015684-q10sx1dm	420	29	an	an	DT
cord-015684-q10sx1dm	420	30	endogenous	endogenous	JJ
cord-015684-q10sx1dm	420	31	nucleotide	nucleotide	NN
cord-015684-q10sx1dm	420	32	and	and	CC
cord-015684-q10sx1dm	420	33	choline	choline	NN
cord-015684-q10sx1dm	420	34	donor	donor	NN
cord-015684-q10sx1dm	420	35	,	,	,
cord-015684-q10sx1dm	420	36	CDP	CDP	NNP
cord-015684-q10sx1dm	420	37	-	-	HYPH
cord-015684-q10sx1dm	420	38	choline	choline	NN
cord-015684-q10sx1dm	420	39	(	(	-LRB-
cord-015684-q10sx1dm	420	40	500	500	CD
cord-015684-q10sx1dm	420	41	mg	mg	NNP
cord-015684-q10sx1dm	420	42	/	/	SYM
cord-015684-q10sx1dm	420	43	day	day	NN
cord-015684-q10sx1dm	420	44	)	)	-RRB-
cord-015684-q10sx1dm	420	45	,	,	,
cord-015684-q10sx1dm	420	46	(	(	-LRB-
cord-015684-q10sx1dm	420	47	b	b	LS
cord-015684-q10sx1dm	420	48	)	)	-RRB-
cord-015684-q10sx1dm	420	49	a	a	DT
cord-015684-q10sx1dm	420	50	nootropic	nootropic	NN
cord-015684-q10sx1dm	420	51	substance	substance	NN
cord-015684-q10sx1dm	420	52	,	,	,
cord-015684-q10sx1dm	420	53	piracetam	piracetam	NNP
cord-015684-q10sx1dm	420	54	(	(	-LRB-
cord-015684-q10sx1dm	420	55	1,600	1,600	CD
cord-015684-q10sx1dm	420	56	mg	mg	NNP
cord-015684-q10sx1dm	420	57	/	/	SYM
cord-015684-q10sx1dm	420	58	day	day	NN
cord-015684-q10sx1dm	420	59	)	)	-RRB-
cord-015684-q10sx1dm	420	60	,	,	,
cord-015684-q10sx1dm	420	61	(	(	-LRB-
cord-015684-q10sx1dm	420	62	c	c	NN
cord-015684-q10sx1dm	420	63	)	)	-RRB-
cord-015684-q10sx1dm	420	64	a	a	DT
cord-015684-q10sx1dm	420	65	vasoactive	vasoactive	JJ
cord-015684-q10sx1dm	420	66	compound	compound	NN
cord-015684-q10sx1dm	420	67	,	,	,
cord-015684-q10sx1dm	420	68	1,6	1,6	CD
cord-015684-q10sx1dm	420	69	dimethyl	dimethyl	NN
cord-015684-q10sx1dm	420	70	8β-(5bromonicotinoyl	8β-(5bromonicotinoyl	NNP
cord-015684-q10sx1dm	420	71	-	-	HYPH
cord-015684-q10sx1dm	420	72	oxymethyl)-10α	oxymethyl)-10α	NN
cord-015684-q10sx1dm	420	73	-	-	HYPH
cord-015684-q10sx1dm	420	74	methoxyergoline	methoxyergoline	NNP
cord-015684-q10sx1dm	420	75	(	(	-LRB-
cord-015684-q10sx1dm	420	76	nicergoline	nicergoline	NN
cord-015684-q10sx1dm	420	77	)	)	-RRB-
cord-015684-q10sx1dm	420	78	(	(	-LRB-
cord-015684-q10sx1dm	420	79	(	(	-LRB-
cord-015684-q10sx1dm	420	80	Fig	Fig	NNP
cord-015684-q10sx1dm	420	81	.	.	NNP
cord-015684-q10sx1dm	420	82	40.10	40.10	CD
cord-015684-q10sx1dm	420	83	)	)	-RRB-
cord-015684-q10sx1dm	420	84	.	.	.
cord-015684-q10sx1dm	421	1	Among	among	IN
cord-015684-q10sx1dm	421	2	EMs	EMs	NNP
cord-015684-q10sx1dm	421	3	,	,	,
cord-015684-q10sx1dm	421	4	AD	ad	NN
cord-015684-q10sx1dm	421	5	patients	patient	NNS
cord-015684-q10sx1dm	421	6	harbouring	harbour	VBG
cord-015684-q10sx1dm	421	7	the	the	DT
cord-015684-q10sx1dm	421	8	*	*	NFP
cord-015684-q10sx1dm	421	9	1/	1/	CD
cord-015684-q10sx1dm	421	10	*	*	NFP
cord-015684-q10sx1dm	421	11	10	10	CD
cord-015684-q10sx1dm	421	12	genotype	genotype	NN
cord-015684-q10sx1dm	421	13	responded	respond	VBD
cord-015684-q10sx1dm	421	14	better	well	RBR
cord-015684-q10sx1dm	421	15	than	than	IN
cord-015684-q10sx1dm	421	16	patients	patient	NNS
cord-015684-q10sx1dm	421	17	with	with	IN
cord-015684-q10sx1dm	421	18	the	the	DT
cord-015684-q10sx1dm	421	19	*	*	NFP
cord-015684-q10sx1dm	421	20	1/	1/	CD
cord-015684-q10sx1dm	421	21	*	*	NFP
cord-015684-q10sx1dm	421	22	1	1	CD
cord-015684-q10sx1dm	421	23	genotype	genotype	NN
cord-015684-q10sx1dm	421	24	.	.	.
cord-015684-q10sx1dm	422	1	The	the	DT
cord-015684-q10sx1dm	422	2	best	good	JJS
cord-015684-q10sx1dm	422	3	responders	responder	NNS
cord-015684-q10sx1dm	422	4	among	among	IN
cord-015684-q10sx1dm	422	5	IMs	IMs	NNP
cord-015684-q10sx1dm	422	6	were	be	VBD
cord-015684-q10sx1dm	422	7	the	the	DT
cord-015684-q10sx1dm	422	8	*	*	NFP
cord-015684-q10sx1dm	422	9	1/	1/	CD
cord-015684-q10sx1dm	422	10	*	*	NFP
cord-015684-q10sx1dm	422	11	3	3	CD
cord-015684-q10sx1dm	422	12	,	,	,
cord-015684-q10sx1dm	422	13	*	*	NFP
cord-015684-q10sx1dm	422	14	1/	1/	CD
cord-015684-q10sx1dm	422	15	*	*	NFP
cord-015684-q10sx1dm	422	16	6	6	CD
cord-015684-q10sx1dm	422	17	and	and	CC
cord-015684-q10sx1dm	422	18	*	*	NFP
cord-015684-q10sx1dm	422	19	1/	1/	CD
cord-015684-q10sx1dm	422	20	*	*	NFP
cord-015684-q10sx1dm	422	21	5	5	CD
cord-015684-q10sx1dm	422	22	genotypes	genotype	NNS
cord-015684-q10sx1dm	422	23	,	,	,
cord-015684-q10sx1dm	422	24	whereas	whereas	IN
cord-015684-q10sx1dm	422	25	the	the	DT
cord-015684-q10sx1dm	422	26	*	*	NFP
cord-015684-q10sx1dm	422	27	1/	1/	CD
cord-015684-q10sx1dm	422	28	*	*	NFP
cord-015684-q10sx1dm	422	29	4	4	CD
cord-015684-q10sx1dm	422	30	,	,	,
cord-015684-q10sx1dm	422	31	*	*	NFP
cord-015684-q10sx1dm	422	32	10/	10/	LS
cord-015684-q10sx1dm	422	33	*	*	NFP
cord-015684-q10sx1dm	422	34	10	10	CD
cord-015684-q10sx1dm	422	35	,	,	,
cord-015684-q10sx1dm	422	36	and	and	CC
cord-015684-q10sx1dm	423	1	*	*	NFP
cord-015684-q10sx1dm	423	2	4/	4/	CD
cord-015684-q10sx1dm	423	3	*	*	NFP
cord-015684-q10sx1dm	423	4	10	10	CD
cord-015684-q10sx1dm	423	5	genotypes	genotype	NNS
cord-015684-q10sx1dm	423	6	were	be	VBD
cord-015684-q10sx1dm	423	7	poor	poor	JJ
cord-015684-q10sx1dm	423	8	responders	responder	NNS
cord-015684-q10sx1dm	423	9	.	.	.
cord-015684-q10sx1dm	424	1	Among	among	IN
cord-015684-q10sx1dm	424	2	PMs	pm	NNS
cord-015684-q10sx1dm	424	3	and	and	CC
cord-015684-q10sx1dm	424	4	UMs	UMs	NNPS
cord-015684-q10sx1dm	424	5	,	,	,
cord-015684-q10sx1dm	424	6	the	the	DT
cord-015684-q10sx1dm	424	7	poorest	poor	JJS
cord-015684-q10sx1dm	424	8	responders	responder	NNS
cord-015684-q10sx1dm	424	9	were	be	VBD
cord-015684-q10sx1dm	424	10	carriers	carrier	NNS
cord-015684-q10sx1dm	424	11	of	of	IN
cord-015684-q10sx1dm	424	12	the	the	DT
cord-015684-q10sx1dm	425	1	*	*	NFP
cord-015684-q10sx1dm	425	2	4/	4/	CD
cord-015684-q10sx1dm	425	3	*	*	NFP
cord-015684-q10sx1dm	425	4	4	4	CD
cord-015684-q10sx1dm	425	5	and	and	CC
cord-015684-q10sx1dm	425	6	*	*	NFP
cord-015684-q10sx1dm	425	7	1xN/	1xn/	CD
cord-015684-q10sx1dm	425	8	*	*	NFP
cord-015684-q10sx1dm	426	1	1	1	CD
cord-015684-q10sx1dm	426	2	genotypes	genotype	NNS
cord-015684-q10sx1dm	426	3	,	,	,
cord-015684-q10sx1dm	426	4	respectively	respectively	RB
cord-015684-q10sx1dm	426	5	.	.	.
cord-015684-q10sx1dm	427	1	20	20	CD
cord-015684-q10sx1dm	427	2	,	,	,
cord-015684-q10sx1dm	427	3	77	77	CD
cord-015684-q10sx1dm	427	4	,	,	,
cord-015684-q10sx1dm	427	5	109	109	CD
cord-015684-q10sx1dm	427	6	From	from	IN
cord-015684-q10sx1dm	427	7	all	all	PDT
cord-015684-q10sx1dm	427	8	these	these	DT
cord-015684-q10sx1dm	427	9	data	datum	NNS
cord-015684-q10sx1dm	427	10	we	-PRON-	PRP
cord-015684-q10sx1dm	427	11	can	can	MD
cord-015684-q10sx1dm	427	12	conclude	conclude	VB
cord-015684-q10sx1dm	427	13	the	the	DT
cord-015684-q10sx1dm	427	14	following	follow	VBG
cord-015684-q10sx1dm	427	15	:	:	:
cord-015684-q10sx1dm	428	1	(	(	-LRB-
cord-015684-q10sx1dm	428	2	i	i	NN
cord-015684-q10sx1dm	428	3	)	)	-RRB-
cord-015684-q10sx1dm	429	1	The	the	DT
cord-015684-q10sx1dm	429	2	most	most	RBS
cord-015684-q10sx1dm	429	3	frequent	frequent	JJ
cord-015684-q10sx1dm	429	4	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	429	5	variants	variant	NNS
cord-015684-q10sx1dm	429	6	in	in	IN
cord-015684-q10sx1dm	429	7	the	the	DT
cord-015684-q10sx1dm	429	8	Spanish	spanish	JJ
cord-015684-q10sx1dm	429	9	population	population	NN
cord-015684-q10sx1dm	429	10	are	be	VBP
cord-015684-q10sx1dm	429	11	the	the	DT
cord-015684-q10sx1dm	429	12	*	*	NFP
cord-015684-q10sx1dm	429	13	1/	1/	CD
cord-015684-q10sx1dm	429	14	*	*	NFP
cord-015684-q10sx1dm	429	15	1	1	CD
cord-015684-q10sx1dm	429	16	(	(	-LRB-
cord-015684-q10sx1dm	429	17	47.10	47.10	CD
cord-015684-q10sx1dm	429	18	%	%	NN
cord-015684-q10sx1dm	429	19	)	)	-RRB-
cord-015684-q10sx1dm	429	20	,	,	,
cord-015684-q10sx1dm	429	21	*	*	NFP
cord-015684-q10sx1dm	429	22	1/	1/	CD
cord-015684-q10sx1dm	429	23	*	*	NFP
cord-015684-q10sx1dm	429	24	4	4	CD
cord-015684-q10sx1dm	429	25	(	(	-LRB-
cord-015684-q10sx1dm	429	26	17.42	17.42	CD
cord-015684-q10sx1dm	429	27	%	%	NN
cord-015684-q10sx1dm	429	28	)	)	-RRB-
cord-015684-q10sx1dm	429	29	,	,	.
cord-015684-q10sx1dm	430	1	*	*	NFP
cord-015684-q10sx1dm	430	2	4/	4/	CD
cord-015684-q10sx1dm	430	3	*	*	NFP
cord-015684-q10sx1dm	430	4	4	4	CD
cord-015684-q10sx1dm	430	5	(	(	-LRB-
cord-015684-q10sx1dm	430	6	8.37	8.37	CD
cord-015684-q10sx1dm	430	7	%	%	NN
cord-015684-q10sx1dm	430	8	)	)	-RRB-
cord-015684-q10sx1dm	430	9	,	,	.
cord-015684-q10sx1dm	431	1	*	*	NFP
cord-015684-q10sx1dm	431	2	1/	1/	CD
cord-015684-q10sx1dm	431	3	*	*	NFP
cord-015684-q10sx1dm	431	4	10	10	CD
cord-015684-q10sx1dm	431	5	(	(	-LRB-
cord-015684-q10sx1dm	431	6	4.52	4.52	CD
cord-015684-q10sx1dm	431	7	%	%	NN
cord-015684-q10sx1dm	431	8	)	)	-RRB-
cord-015684-q10sx1dm	432	1	and	and	CC
cord-015684-q10sx1dm	432	2	*	*	NFP
cord-015684-q10sx1dm	432	3	1xN/	1xn/	CD
cord-015684-q10sx1dm	432	4	*	*	NFP
cord-015684-q10sx1dm	432	5	1	1	CD
cord-015684-q10sx1dm	432	6	(	(	-LRB-
cord-015684-q10sx1dm	432	7	4.52	4.52	CD
cord-015684-q10sx1dm	432	8	%	%	NN
cord-015684-q10sx1dm	432	9	)	)	-RRB-
cord-015684-q10sx1dm	432	10	,	,	,
cord-015684-q10sx1dm	432	11	accounting	account	VBG
cord-015684-q10sx1dm	432	12	for	for	IN
cord-015684-q10sx1dm	432	13	more	more	JJR
cord-015684-q10sx1dm	432	14	than	than	IN
cord-015684-q10sx1dm	432	15	80	80	CD
cord-015684-q10sx1dm	432	16	%	%	NN
cord-015684-q10sx1dm	432	17	of	of	IN
cord-015684-q10sx1dm	432	18	the	the	DT
cord-015684-q10sx1dm	432	19	population	population	NN
cord-015684-q10sx1dm	432	20	;	;	,
cord-015684-q10sx1dm	432	21	(	(	-LRB-
cord-015684-q10sx1dm	432	22	ii	ii	NN
cord-015684-q10sx1dm	432	23	)	)	-RRB-
cord-015684-q10sx1dm	432	24	the	the	DT
cord-015684-q10sx1dm	432	25	frequency	frequency	NN
cord-015684-q10sx1dm	432	26	of	of	IN
cord-015684-q10sx1dm	432	27	EMs	EMs	NNP
cord-015684-q10sx1dm	432	28	,	,	,
cord-015684-q10sx1dm	432	29	IMs	IMs	NNP
cord-015684-q10sx1dm	432	30	,	,	,
cord-015684-q10sx1dm	432	31	PMs	PMs	NNPS
cord-015684-q10sx1dm	432	32	,	,	,
cord-015684-q10sx1dm	432	33	and	and	CC
cord-015684-q10sx1dm	432	34	UMs	UMs	NNPS
cord-015684-q10sx1dm	432	35	is	be	VBZ
cord-015684-q10sx1dm	432	36	about	about	RB
cord-015684-q10sx1dm	432	37	51.61	51.61	CD
cord-015684-q10sx1dm	432	38	%	%	NN
cord-015684-q10sx1dm	432	39	,	,	,
cord-015684-q10sx1dm	432	40	32.26	32.26	CD
cord-015684-q10sx1dm	432	41	%	%	NN
cord-015684-q10sx1dm	432	42	,	,	,
cord-015684-q10sx1dm	432	43	9.03	9.03	CD
cord-015684-q10sx1dm	432	44	%	%	NN
cord-015684-q10sx1dm	432	45	,	,	,
cord-015684-q10sx1dm	432	46	and	and	CC
cord-015684-q10sx1dm	432	47	7.10	7.10	CD
cord-015684-q10sx1dm	432	48	%	%	NN
cord-015684-q10sx1dm	432	49	,	,	,
cord-015684-q10sx1dm	432	50	respectively	respectively	RB
cord-015684-q10sx1dm	432	51	;	;	,
cord-015684-q10sx1dm	432	52	(	(	-LRB-
cord-015684-q10sx1dm	432	53	iii	iii	NN
cord-015684-q10sx1dm	432	54	)	)	-RRB-
cord-015684-q10sx1dm	432	55	EMs	EMs	NNP
cord-015684-q10sx1dm	432	56	are	be	VBP
cord-015684-q10sx1dm	432	57	more	more	RBR
cord-015684-q10sx1dm	432	58	prevalent	prevalent	JJ
cord-015684-q10sx1dm	432	59	in	in	IN
cord-015684-q10sx1dm	432	60	AD	ad	NN
cord-015684-q10sx1dm	432	61	(	(	-LRB-
cord-015684-q10sx1dm	432	62	57.47	57.47	CD
cord-015684-q10sx1dm	432	63	%	%	NN
cord-015684-q10sx1dm	432	64	)	)	-RRB-
cord-015684-q10sx1dm	432	65	than	than	IN
cord-015684-q10sx1dm	432	66	in	in	IN
cord-015684-q10sx1dm	432	67	controls	control	NNS
cord-015684-q10sx1dm	432	68	(	(	-LRB-
cord-015684-q10sx1dm	432	69	44.12	44.12	CD
cord-015684-q10sx1dm	432	70	%	%	NN
cord-015684-q10sx1dm	432	71	)	)	-RRB-
cord-015684-q10sx1dm	432	72	;	;	:
cord-015684-q10sx1dm	432	73	IMs	IMs	NNP
cord-015684-q10sx1dm	432	74	are	be	VBP
cord-015684-q10sx1dm	432	75	more	more	RBR
cord-015684-q10sx1dm	432	76	frequent	frequent	JJ
cord-015684-q10sx1dm	432	77	in	in	IN
cord-015684-q10sx1dm	432	78	controls	control	NNS
cord-015684-q10sx1dm	432	79	(	(	-LRB-
cord-015684-q10sx1dm	432	80	41.18	41.18	CD
cord-015684-q10sx1dm	432	81	%	%	NN
cord-015684-q10sx1dm	432	82	)	)	-RRB-
cord-015684-q10sx1dm	432	83	Fig	fig	NN
cord-015684-q10sx1dm	432	84	.	.	.
cord-015684-q10sx1dm	433	1	40	40	CD
cord-015684-q10sx1dm	433	2	.10	.10	.
cord-015684-q10sx1dm	434	1	CYP2D6-related	cyp2d6-related	JJ
cord-015684-q10sx1dm	434	2	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	434	3	response	response	NN
cord-015684-q10sx1dm	434	4	to	to	IN
cord-015684-q10sx1dm	434	5	a	a	DT
cord-015684-q10sx1dm	434	6	multifactorial	multifactorial	JJ
cord-015684-q10sx1dm	434	7	treatment	treatment	NN
cord-015684-q10sx1dm	434	8	in	in	IN
cord-015684-q10sx1dm	434	9	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	434	10	's	's	POS
cord-015684-q10sx1dm	434	11	disease	disease	NN
cord-015684-q10sx1dm	434	12	over	over	IN
cord-015684-q10sx1dm	434	13	a	a	DT
cord-015684-q10sx1dm	434	14	1-year	1-year	CD
cord-015684-q10sx1dm	434	15	period	period	NN
cord-015684-q10sx1dm	434	16	(	(	-LRB-
cord-015684-q10sx1dm	434	17	Adapted	adapt	VBN
cord-015684-q10sx1dm	434	18	from	from	IN
cord-015684-q10sx1dm	434	19	R.	R.	NNP
cord-015684-q10sx1dm	434	20	Cacabelos	Cacabelos	NNP
cord-015684-q10sx1dm	434	21	77	77	CD
cord-015684-q10sx1dm	434	22	,	,	,
cord-015684-q10sx1dm	434	23	109	109	CD
cord-015684-q10sx1dm	434	24	)	)	-RRB-
cord-015684-q10sx1dm	435	1	.Patients	.patient	NNS
cord-015684-q10sx1dm	435	2	received	receive	VBD
cord-015684-q10sx1dm	435	3	a	a	DT
cord-015684-q10sx1dm	435	4	combina	combina	NN
cord-015684-q10sx1dm	435	5	-	-	HYPH
cord-015684-q10sx1dm	435	6	tion	tion	NN
cord-015684-q10sx1dm	435	7	therapy	therapy	NN
cord-015684-q10sx1dm	435	8	for	for	IN
cord-015684-q10sx1dm	435	9	1	1	CD
cord-015684-q10sx1dm	435	10	year	year	NN
cord-015684-q10sx1dm	435	11	,	,	,
cord-015684-q10sx1dm	435	12	and	and	CC
cord-015684-q10sx1dm	435	13	cognitive	cognitive	JJ
cord-015684-q10sx1dm	435	14	function	function	NN
cord-015684-q10sx1dm	435	15	(	(	-LRB-
cord-015684-q10sx1dm	435	16	MMSE	MMSE	NNP
cord-015684-q10sx1dm	435	17	score	score	NN
cord-015684-q10sx1dm	435	18	)	)	-RRB-
cord-015684-q10sx1dm	435	19	was	be	VBD
cord-015684-q10sx1dm	435	20	assessed	assess	VBN
cord-015684-q10sx1dm	435	21	at	at	IN
cord-015684-q10sx1dm	435	22	baseline	baseline	NN
cord-015684-q10sx1dm	435	23	(	(	-LRB-
cord-015684-q10sx1dm	435	24	B	b	NN
cord-015684-q10sx1dm	435	25	)	)	-RRB-
cord-015684-q10sx1dm	435	26	and	and	CC
cord-015684-q10sx1dm	435	27	after	after	IN
cord-015684-q10sx1dm	435	28	1	1	CD
cord-015684-q10sx1dm	435	29	,	,	,
cord-015684-q10sx1dm	435	30	3	3	CD
cord-015684-q10sx1dm	435	31	,	,	,
cord-015684-q10sx1dm	435	32	6	6	CD
cord-015684-q10sx1dm	435	33	,	,	,
cord-015684-q10sx1dm	435	34	9	9	CD
cord-015684-q10sx1dm	435	35	,	,	,
cord-015684-q10sx1dm	435	36	and	and	CC
cord-015684-q10sx1dm	435	37	12	12	CD
cord-015684-q10sx1dm	435	38	months	month	NNS
cord-015684-q10sx1dm	435	39	of	of	IN
cord-015684-q10sx1dm	435	40	treatment	treatment	NN
cord-015684-q10sx1dm	435	41	.	.	.
cord-015684-q10sx1dm	436	1	than	than	IN
cord-015684-q10sx1dm	436	2	in	in	IN
cord-015684-q10sx1dm	436	3	AD	ad	NN
cord-015684-q10sx1dm	436	4	(	(	-LRB-
cord-015684-q10sx1dm	436	5	25.29	25.29	CD
cord-015684-q10sx1dm	436	6	%	%	NN
cord-015684-q10sx1dm	436	7	)	)	-RRB-
cord-015684-q10sx1dm	436	8	,	,	,
cord-015684-q10sx1dm	436	9	especially	especially	RB
cord-015684-q10sx1dm	436	10	the	the	DT
cord-015684-q10sx1dm	436	11	*	*	NFP
cord-015684-q10sx1dm	436	12	1/	1/	CD
cord-015684-q10sx1dm	436	13	*	*	NFP
cord-015684-q10sx1dm	436	14	4	4	CD
cord-015684-q10sx1dm	436	15	(	(	-LRB-
cord-015684-q10sx1dm	436	16	C	c	NN
cord-015684-q10sx1dm	436	17	:	:	:
cord-015684-q10sx1dm	436	18	23.53	23.53	CD
cord-015684-q10sx1dm	436	19	%	%	NN
cord-015684-q10sx1dm	436	20	;	;	:
cord-015684-q10sx1dm	436	21	AD	ad	NN
cord-015684-q10sx1dm	436	22	:	:	:
cord-015684-q10sx1dm	436	23	12.64	12.64	CD
cord-015684-q10sx1dm	436	24	%	%	NN
cord-015684-q10sx1dm	436	25	)	)	-RRB-
cord-015684-q10sx1dm	437	1	and	and	CC
cord-015684-q10sx1dm	437	2	*	*	NFP
cord-015684-q10sx1dm	437	3	4/	4/	CD
cord-015684-q10sx1dm	437	4	*	*	NFP
cord-015684-q10sx1dm	437	5	10	10	CD
cord-015684-q10sx1dm	437	6	genotypes	genotype	NNS
cord-015684-q10sx1dm	437	7	(	(	-LRB-
cord-015684-q10sx1dm	437	8	C	c	NN
cord-015684-q10sx1dm	437	9	:	:	:
cord-015684-q10sx1dm	437	10	5.88	5.88	CD
cord-015684-q10sx1dm	437	11	%	%	NN
cord-015684-q10sx1dm	437	12	;	;	:
cord-015684-q10sx1dm	437	13	AD	ad	NN
cord-015684-q10sx1dm	437	14	:	:	:
cord-015684-q10sx1dm	437	15	1.15	1.15	CD
cord-015684-q10sx1dm	437	16	%	%	NN
cord-015684-q10sx1dm	437	17	)	)	-RRB-
cord-015684-q10sx1dm	437	18	;	;	:
cord-015684-q10sx1dm	437	19	the	the	DT
cord-015684-q10sx1dm	437	20	frequency	frequency	NN
cord-015684-q10sx1dm	437	21	of	of	IN
cord-015684-q10sx1dm	437	22	PMs	PMs	NNP
cord-015684-q10sx1dm	437	23	is	be	VBZ
cord-015684-q10sx1dm	437	24	similar	similar	JJ
cord-015684-q10sx1dm	437	25	in	in	IN
cord-015684-q10sx1dm	437	26	AD	ad	NN
cord-015684-q10sx1dm	437	27	(	(	-LRB-
cord-015684-q10sx1dm	437	28	9.20	9.20	CD
cord-015684-q10sx1dm	437	29	%	%	NN
cord-015684-q10sx1dm	437	30	)	)	-RRB-
cord-015684-q10sx1dm	437	31	and	and	CC
cord-015684-q10sx1dm	437	32	controls	control	NNS
cord-015684-q10sx1dm	437	33	(	(	-LRB-
cord-015684-q10sx1dm	437	34	8.82	8.82	CD
cord-015684-q10sx1dm	437	35	%	%	NN
cord-015684-q10sx1dm	437	36	)	)	-RRB-
cord-015684-q10sx1dm	437	37	;	;	:
cord-015684-q10sx1dm	437	38	and	and	CC
cord-015684-q10sx1dm	437	39	UMs	um	NNS
cord-015684-q10sx1dm	437	40	are	be	VBP
cord-015684-q10sx1dm	437	41	more	more	RBR
cord-015684-q10sx1dm	437	42	frequent	frequent	JJ
cord-015684-q10sx1dm	437	43	among	among	IN
cord-015684-q10sx1dm	437	44	AD	ad	NN
cord-015684-q10sx1dm	437	45	cases	case	NNS
cord-015684-q10sx1dm	437	46	(	(	-LRB-
cord-015684-q10sx1dm	437	47	8.04	8.04	CD
cord-015684-q10sx1dm	437	48	%	%	NN
cord-015684-q10sx1dm	437	49	)	)	-RRB-
cord-015684-q10sx1dm	437	50	than	than	IN
cord-015684-q10sx1dm	437	51	in	in	IN
cord-015684-q10sx1dm	437	52	controls	control	NNS
cord-015684-q10sx1dm	437	53	(	(	-LRB-
cord-015684-q10sx1dm	437	54	5.88	5.88	CD
cord-015684-q10sx1dm	437	55	%	%	NN
cord-015684-q10sx1dm	437	56	)	)	-RRB-
cord-015684-q10sx1dm	437	57	;	;	:
cord-015684-q10sx1dm	437	58	(	(	-LRB-
cord-015684-q10sx1dm	437	59	iv	iv	LS
cord-015684-q10sx1dm	437	60	)	)	-RRB-
cord-015684-q10sx1dm	437	61	there	there	EX
cord-015684-q10sx1dm	437	62	is	be	VBZ
cord-015684-q10sx1dm	437	63	an	an	DT
cord-015684-q10sx1dm	437	64	accumulation	accumulation	NN
cord-015684-q10sx1dm	437	65	of	of	IN
cord-015684-q10sx1dm	437	66	AD	ad	NN
cord-015684-q10sx1dm	437	67	-	-	HYPH
cord-015684-q10sx1dm	437	68	related	relate	VBN
cord-015684-q10sx1dm	437	69	genes	gene	NNS
cord-015684-q10sx1dm	437	70	of	of	IN
cord-015684-q10sx1dm	437	71	risk	risk	NN
cord-015684-q10sx1dm	437	72	in	in	IN
cord-015684-q10sx1dm	437	73	PMs	PMs	NNP
cord-015684-q10sx1dm	437	74	and	and	CC
cord-015684-q10sx1dm	437	75	UMs	UMs	NNPS
cord-015684-q10sx1dm	437	76	;	;	,
cord-015684-q10sx1dm	437	77	(	(	-LRB-
cord-015684-q10sx1dm	437	78	v	v	NN
cord-015684-q10sx1dm	437	79	)	)	-RRB-
cord-015684-q10sx1dm	437	80	PMs	PMs	NNPS
cord-015684-q10sx1dm	437	81	and	and	CC
cord-015684-q10sx1dm	437	82	UMs	UMs	NNPS
cord-015684-q10sx1dm	437	83	tend	tend	VBP
cord-015684-q10sx1dm	437	84	to	to	TO
cord-015684-q10sx1dm	437	85	show	show	VB
cord-015684-q10sx1dm	437	86	higher	high	JJR
cord-015684-q10sx1dm	437	87	transaminase	transaminase	NN
cord-015684-q10sx1dm	437	88	activities	activity	NNS
cord-015684-q10sx1dm	437	89	than	than	IN
cord-015684-q10sx1dm	437	90	EMs	EMs	NNP
cord-015684-q10sx1dm	437	91	and	and	CC
cord-015684-q10sx1dm	437	92	IMs	IMs	NNP
cord-015684-q10sx1dm	437	93	;	;	:
cord-015684-q10sx1dm	437	94	(	(	-LRB-
cord-015684-q10sx1dm	437	95	vi	vi	NNP
cord-015684-q10sx1dm	437	96	)	)	-RRB-
cord-015684-q10sx1dm	437	97	EMs	EMs	NNP
cord-015684-q10sx1dm	437	98	and	and	CC
cord-015684-q10sx1dm	437	99	IMs	IMs	NNP
cord-015684-q10sx1dm	437	100	are	be	VBP
cord-015684-q10sx1dm	437	101	the	the	DT
cord-015684-q10sx1dm	437	102	best	good	JJS
cord-015684-q10sx1dm	437	103	responders	responder	NNS
cord-015684-q10sx1dm	437	104	,	,	,
cord-015684-q10sx1dm	437	105	and	and	CC
cord-015684-q10sx1dm	437	106	PMs	pm	NNS
cord-015684-q10sx1dm	437	107	and	and	CC
cord-015684-q10sx1dm	437	108	UMs	UMs	NNPS
cord-015684-q10sx1dm	437	109	are	be	VBP
cord-015684-q10sx1dm	437	110	the	the	DT
cord-015684-q10sx1dm	437	111	worst	bad	JJS
cord-015684-q10sx1dm	437	112	responders	responder	NNS
cord-015684-q10sx1dm	437	113	to	to	IN
cord-015684-q10sx1dm	437	114	a	a	DT
cord-015684-q10sx1dm	437	115	combination	combination	NN
cord-015684-q10sx1dm	437	116	therapy	therapy	NN
cord-015684-q10sx1dm	437	117	with	with	IN
cord-015684-q10sx1dm	437	118	cholinesterase	cholinesterase	NN
cord-015684-q10sx1dm	437	119	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	437	120	,	,	,
cord-015684-q10sx1dm	437	121	neuroprotectants	neuroprotectant	NNS
cord-015684-q10sx1dm	437	122	,	,	,
cord-015684-q10sx1dm	437	123	and	and	CC
cord-015684-q10sx1dm	437	124	vasoactive	vasoactive	JJ
cord-015684-q10sx1dm	437	125	substances	substance	NNS
cord-015684-q10sx1dm	437	126	;	;	:
cord-015684-q10sx1dm	437	127	and	and	CC
cord-015684-q10sx1dm	437	128	(	(	-LRB-
cord-015684-q10sx1dm	437	129	vii	vii	NN
cord-015684-q10sx1dm	437	130	)	)	-RRB-
cord-015684-q10sx1dm	438	1	the	the	DT
cord-015684-q10sx1dm	438	2	pharmacogenetic	pharmacogenetic	JJ
cord-015684-q10sx1dm	438	3	response	response	NN
cord-015684-q10sx1dm	438	4	in	in	IN
cord-015684-q10sx1dm	438	5	AD	ad	NN
cord-015684-q10sx1dm	438	6	appears	appear	VBZ
cord-015684-q10sx1dm	438	7	to	to	TO
cord-015684-q10sx1dm	438	8	be	be	VB
cord-015684-q10sx1dm	438	9	dependent	dependent	JJ
cord-015684-q10sx1dm	438	10	upon	upon	IN
cord-015684-q10sx1dm	438	11	the	the	DT
cord-015684-q10sx1dm	438	12	networking	networking	NN
cord-015684-q10sx1dm	438	13	activity	activity	NN
cord-015684-q10sx1dm	438	14	of	of	IN
cord-015684-q10sx1dm	438	15	genes	gene	NNS
cord-015684-q10sx1dm	438	16	involved	involve	VBN
cord-015684-q10sx1dm	438	17	in	in	IN
cord-015684-q10sx1dm	438	18	drug	drug	NN
cord-015684-q10sx1dm	438	19	metabolism	metabolism	NN
cord-015684-q10sx1dm	438	20	and	and	CC
cord-015684-q10sx1dm	438	21	genes	gene	NNS
cord-015684-q10sx1dm	438	22	involved	involve	VBN
cord-015684-q10sx1dm	438	23	in	in	IN
cord-015684-q10sx1dm	438	24	AD	ad	NN
cord-015684-q10sx1dm	438	25	pathogenesis	pathogenesis	NN
cord-015684-q10sx1dm	438	26	.	.	.
cord-015684-q10sx1dm	439	1	[	[	-LRB-
cord-015684-q10sx1dm	439	2	16	16	CD
cord-015684-q10sx1dm	439	3	]	]	-RRB-
cord-015684-q10sx1dm	439	4	[	[	-LRB-
cord-015684-q10sx1dm	439	5	17	17	CD
cord-015684-q10sx1dm	439	6	]	]	-RRB-
cord-015684-q10sx1dm	439	7	[	[	-LRB-
cord-015684-q10sx1dm	439	8	18	18	CD
cord-015684-q10sx1dm	439	9	]	]	-RRB-
cord-015684-q10sx1dm	439	10	[	[	-LRB-
cord-015684-q10sx1dm	439	11	19	19	CD
cord-015684-q10sx1dm	439	12	]	]	-RRB-
cord-015684-q10sx1dm	440	1	[	[	-LRB-
cord-015684-q10sx1dm	440	2	20	20	CD
cord-015684-q10sx1dm	440	3	]	]	-RRB-
cord-015684-q10sx1dm	440	4	[	[	-LRB-
cord-015684-q10sx1dm	440	5	74	74	CD
cord-015684-q10sx1dm	440	6	]	]	-RRB-
cord-015684-q10sx1dm	441	1	[	[	-LRB-
cord-015684-q10sx1dm	441	2	75	75	CD
cord-015684-q10sx1dm	441	3	]	]	-RRB-
cord-015684-q10sx1dm	441	4	[	[	-LRB-
cord-015684-q10sx1dm	441	5	76	76	CD
cord-015684-q10sx1dm	441	6	]	]	-RRB-
cord-015684-q10sx1dm	441	7	[	[	-LRB-
cord-015684-q10sx1dm	441	8	77	77	CD
cord-015684-q10sx1dm	441	9	]	]	-RRB-
cord-015684-q10sx1dm	441	10	109	109	CD
cord-015684-q10sx1dm	441	11	,	,	,
cord-015684-q10sx1dm	441	12	110	110	CD
cord-015684-q10sx1dm	441	13	Taking	take	VBG
cord-015684-q10sx1dm	441	14	into	into	IN
cord-015684-q10sx1dm	441	15	consideration	consideration	NN
cord-015684-q10sx1dm	441	16	the	the	DT
cord-015684-q10sx1dm	441	17	available	available	JJ
cord-015684-q10sx1dm	441	18	data	datum	NNS
cord-015684-q10sx1dm	441	19	,	,	,
cord-015684-q10sx1dm	441	20	it	-PRON-	PRP
cord-015684-q10sx1dm	441	21	might	may	MD
cord-015684-q10sx1dm	441	22	be	be	VB
cord-015684-q10sx1dm	441	23	inferred	infer	VBN
cord-015684-q10sx1dm	441	24	that	that	IN
cord-015684-q10sx1dm	441	25	at	at	RB
cord-015684-q10sx1dm	441	26	least	least	RBS
cord-015684-q10sx1dm	441	27	15	15	CD
cord-015684-q10sx1dm	441	28	%	%	NN
cord-015684-q10sx1dm	441	29	of	of	IN
cord-015684-q10sx1dm	441	30	the	the	DT
cord-015684-q10sx1dm	441	31	AD	ad	NN
cord-015684-q10sx1dm	441	32	population	population	NN
cord-015684-q10sx1dm	441	33	may	may	MD
cord-015684-q10sx1dm	441	34	exhibit	exhibit	VB
cord-015684-q10sx1dm	441	35	an	an	DT
cord-015684-q10sx1dm	441	36	abnormal	abnormal	JJ
cord-015684-q10sx1dm	441	37	metabolism	metabolism	NN
cord-015684-q10sx1dm	441	38	of	of	IN
cord-015684-q10sx1dm	441	39	cholinesterase	cholinesterase	NN
cord-015684-q10sx1dm	441	40	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	441	41	and/or	and/or	CC
cord-015684-q10sx1dm	441	42	other	other	JJ
cord-015684-q10sx1dm	441	43	drugs	drug	NNS
cord-015684-q10sx1dm	441	44	which	which	WDT
cord-015684-q10sx1dm	441	45	undergo	undergo	VBP
cord-015684-q10sx1dm	441	46	oxidation	oxidation	NN
cord-015684-q10sx1dm	441	47	via	via	IN
cord-015684-q10sx1dm	441	48	CYP2D6-related	cyp2d6-related	JJ
cord-015684-q10sx1dm	441	49	enzymes	enzyme	NNS
cord-015684-q10sx1dm	441	50	.	.	.
cord-015684-q10sx1dm	442	1	Approximately	approximately	RB
cord-015684-q10sx1dm	442	2	50	50	CD
cord-015684-q10sx1dm	442	3	%	%	NN
cord-015684-q10sx1dm	442	4	of	of	IN
cord-015684-q10sx1dm	442	5	this	this	DT
cord-015684-q10sx1dm	442	6	population	population	NN
cord-015684-q10sx1dm	442	7	cluster	cluster	NN
cord-015684-q10sx1dm	442	8	would	would	MD
cord-015684-q10sx1dm	442	9	show	show	VB
cord-015684-q10sx1dm	442	10	an	an	DT
cord-015684-q10sx1dm	442	11	ultrarapid	ultrarapid	NN
cord-015684-q10sx1dm	442	12	metabolism	metabolism	NN
cord-015684-q10sx1dm	442	13	,	,	,
cord-015684-q10sx1dm	442	14	requiring	require	VBG
cord-015684-q10sx1dm	442	15	higher	high	JJR
cord-015684-q10sx1dm	442	16	doses	dose	NNS
cord-015684-q10sx1dm	442	17	of	of	IN
cord-015684-q10sx1dm	442	18	cholinesterase	cholinesterase	NN
cord-015684-q10sx1dm	442	19	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	442	20	to	to	TO
cord-015684-q10sx1dm	442	21	reach	reach	VB
cord-015684-q10sx1dm	442	22	a	a	DT
cord-015684-q10sx1dm	442	23	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	442	24	threshold	threshold	NN
cord-015684-q10sx1dm	442	25	,	,	,
cord-015684-q10sx1dm	442	26	whereas	whereas	IN
cord-015684-q10sx1dm	442	27	the	the	DT
cord-015684-q10sx1dm	442	28	other	other	JJ
cord-015684-q10sx1dm	442	29	50	50	CD
cord-015684-q10sx1dm	442	30	%	%	NN
cord-015684-q10sx1dm	442	31	of	of	IN
cord-015684-q10sx1dm	442	32	the	the	DT
cord-015684-q10sx1dm	442	33	cluster	cluster	NN
cord-015684-q10sx1dm	442	34	would	would	MD
cord-015684-q10sx1dm	442	35	exhibit	exhibit	VB
cord-015684-q10sx1dm	442	36	a	a	DT
cord-015684-q10sx1dm	442	37	poor	poor	JJ
cord-015684-q10sx1dm	442	38	metabolism	metabolism	NN
cord-015684-q10sx1dm	442	39	,	,	,
cord-015684-q10sx1dm	442	40	displaying	display	VBG
cord-015684-q10sx1dm	442	41	potential	potential	JJ
cord-015684-q10sx1dm	442	42	adverse	adverse	JJ
cord-015684-q10sx1dm	442	43	events	event	NNS
cord-015684-q10sx1dm	442	44	at	at	IN
cord-015684-q10sx1dm	442	45	low	low	JJ
cord-015684-q10sx1dm	442	46	doses	dose	NNS
cord-015684-q10sx1dm	442	47	.	.	.
cord-015684-q10sx1dm	443	1	If	if	IN
cord-015684-q10sx1dm	443	2	we	-PRON-	PRP
cord-015684-q10sx1dm	443	3	take	take	VBP
cord-015684-q10sx1dm	443	4	into	into	IN
cord-015684-q10sx1dm	443	5	account	account	NN
cord-015684-q10sx1dm	443	6	that	that	IN
cord-015684-q10sx1dm	443	7	approximately	approximately	RB
cord-015684-q10sx1dm	443	8	60	60	CD
cord-015684-q10sx1dm	443	9	-	-	SYM
cord-015684-q10sx1dm	443	10	70	70	CD
cord-015684-q10sx1dm	443	11	%	%	NN
cord-015684-q10sx1dm	443	12	of	of	IN
cord-015684-q10sx1dm	443	13	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	443	14	outcomes	outcome	NNS
cord-015684-q10sx1dm	443	15	depend	depend	VBP
cord-015684-q10sx1dm	443	16	upon	upon	IN
cord-015684-q10sx1dm	443	17	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	443	18	criteria	criterion	NNS
cord-015684-q10sx1dm	443	19	(	(	-LRB-
cord-015684-q10sx1dm	443	20	e.g.	e.g.	RB
cord-015684-q10sx1dm	443	21	,	,	,
cord-015684-q10sx1dm	443	22	pathogenic	pathogenic	JJ
cord-015684-q10sx1dm	443	23	mechanisms	mechanism	NNS
cord-015684-q10sx1dm	443	24	associated	associate	VBN
cord-015684-q10sx1dm	443	25	with	with	IN
cord-015684-q10sx1dm	443	26	AD	ad	NN
cord-015684-q10sx1dm	443	27	-	-	HYPH
cord-015684-q10sx1dm	443	28	related	relate	VBN
cord-015684-q10sx1dm	443	29	genes	gene	NNS
cord-015684-q10sx1dm	443	30	)	)	-RRB-
cord-015684-q10sx1dm	443	31	,	,	,
cord-015684-q10sx1dm	443	32	it	-PRON-	PRP
cord-015684-q10sx1dm	443	33	can	can	MD
cord-015684-q10sx1dm	443	34	be	be	VB
cord-015684-q10sx1dm	443	35	postulated	postulate	VBN
cord-015684-q10sx1dm	443	36	that	that	IN
cord-015684-q10sx1dm	443	37	pharmacogenetic	pharmacogenetic	JJ
cord-015684-q10sx1dm	443	38	and	and	CC
cord-015684-q10sx1dm	443	39	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	443	40	factors	factor	NNS
cord-015684-q10sx1dm	443	41	are	be	VBP
cord-015684-q10sx1dm	443	42	responsible	responsible	JJ
cord-015684-q10sx1dm	443	43	for	for	IN
cord-015684-q10sx1dm	443	44	75	75	CD
cord-015684-q10sx1dm	443	45	-	-	SYM
cord-015684-q10sx1dm	443	46	85	85	CD
cord-015684-q10sx1dm	443	47	%	%	NN
cord-015684-q10sx1dm	443	48	of	of	IN
cord-015684-q10sx1dm	443	49	the	the	DT
cord-015684-q10sx1dm	443	50	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	443	51	response	response	NN
cord-015684-q10sx1dm	443	52	(	(	-LRB-
cord-015684-q10sx1dm	443	53	effi	effi	NNP
cord-015684-q10sx1dm	443	54	cacy	cacy	NNP
cord-015684-q10sx1dm	443	55	)	)	-RRB-
cord-015684-q10sx1dm	443	56	in	in	IN
cord-015684-q10sx1dm	443	57	AD	ad	NN
cord-015684-q10sx1dm	443	58	patients	patient	NNS
cord-015684-q10sx1dm	443	59	treated	treat	VBN
cord-015684-q10sx1dm	443	60	with	with	IN
cord-015684-q10sx1dm	443	61	conventional	conventional	JJ
cord-015684-q10sx1dm	443	62	drugs	drug	NNS
cord-015684-q10sx1dm	443	63	.	.	.
cord-015684-q10sx1dm	444	1	[	[	-LRB-
cord-015684-q10sx1dm	444	2	16	16	CD
cord-015684-q10sx1dm	444	3	]	]	-RRB-
cord-015684-q10sx1dm	444	4	[	[	-LRB-
cord-015684-q10sx1dm	444	5	17	17	CD
cord-015684-q10sx1dm	444	6	]	]	-RRB-
cord-015684-q10sx1dm	444	7	[	[	-LRB-
cord-015684-q10sx1dm	444	8	18	18	CD
cord-015684-q10sx1dm	444	9	]	]	-RRB-
cord-015684-q10sx1dm	444	10	[	[	-LRB-
cord-015684-q10sx1dm	444	11	19	19	CD
cord-015684-q10sx1dm	444	12	]	]	-RRB-
cord-015684-q10sx1dm	445	1	[	[	-LRB-
cord-015684-q10sx1dm	445	2	20	20	CD
cord-015684-q10sx1dm	445	3	]	]	-RRB-
cord-015684-q10sx1dm	445	4	[	[	-LRB-
cord-015684-q10sx1dm	445	5	74	74	CD
cord-015684-q10sx1dm	445	6	]	]	-RRB-
cord-015684-q10sx1dm	446	1	[	[	-LRB-
cord-015684-q10sx1dm	446	2	75	75	CD
cord-015684-q10sx1dm	446	3	]	]	-RRB-
cord-015684-q10sx1dm	446	4	[	[	-LRB-
cord-015684-q10sx1dm	446	5	76	76	CD
cord-015684-q10sx1dm	446	6	]	]	-RRB-
cord-015684-q10sx1dm	447	1	[	[	-LRB-
cord-015684-q10sx1dm	447	2	77	77	CD
cord-015684-q10sx1dm	447	3	]	]	-RRB-
cord-015684-q10sx1dm	447	4	109	109	CD
cord-015684-q10sx1dm	447	5	,	,	,
cord-015684-q10sx1dm	447	6	110	110	CD
cord-015684-q10sx1dm	447	7	Of	of	IN
cord-015684-q10sx1dm	447	8	particular	particular	JJ
cord-015684-q10sx1dm	447	9	interest	interest	NN
cord-015684-q10sx1dm	447	10	are	be	VBP
cord-015684-q10sx1dm	447	11	the	the	DT
cord-015684-q10sx1dm	447	12	potential	potential	JJ
cord-015684-q10sx1dm	447	13	interactions	interaction	NNS
cord-015684-q10sx1dm	447	14	of	of	IN
cord-015684-q10sx1dm	447	15	cholinesterase	cholinesterase	NN
cord-015684-q10sx1dm	447	16	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	447	17	with	with	IN
cord-015684-q10sx1dm	447	18	other	other	JJ
cord-015684-q10sx1dm	447	19	drugs	drug	NNS
cord-015684-q10sx1dm	447	20	of	of	IN
cord-015684-q10sx1dm	447	21	current	current	JJ
cord-015684-q10sx1dm	447	22	use	use	NN
cord-015684-q10sx1dm	447	23	in	in	IN
cord-015684-q10sx1dm	447	24	patients	patient	NNS
cord-015684-q10sx1dm	447	25	with	with	IN
cord-015684-q10sx1dm	447	26	AD	ad	NN
cord-015684-q10sx1dm	447	27	,	,	,
cord-015684-q10sx1dm	447	28	such	such	JJ
cord-015684-q10sx1dm	447	29	as	as	IN
cord-015684-q10sx1dm	447	30	antidepressants	antidepressant	NNS
cord-015684-q10sx1dm	447	31	,	,	,
cord-015684-q10sx1dm	447	32	neuroleptics	neuroleptic	NNS
cord-015684-q10sx1dm	447	33	,	,	,
cord-015684-q10sx1dm	447	34	antiarrhythmics	antiarrhythmic	NNS
cord-015684-q10sx1dm	447	35	,	,	,
cord-015684-q10sx1dm	447	36	analgesics	analgesic	NNS
cord-015684-q10sx1dm	447	37	,	,	,
cord-015684-q10sx1dm	447	38	and	and	CC
cord-015684-q10sx1dm	447	39	antiemetics	antiemetic	NNS
cord-015684-q10sx1dm	447	40	which	which	WDT
cord-015684-q10sx1dm	447	41	are	be	VBP
cord-015684-q10sx1dm	447	42	metabolized	metabolize	VBN
cord-015684-q10sx1dm	447	43	by	by	IN
cord-015684-q10sx1dm	447	44	the	the	DT
cord-015684-q10sx1dm	447	45	cytochrome	cytochrome	NN
cord-015684-q10sx1dm	447	46	P450	P450	NNP
cord-015684-q10sx1dm	447	47	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	447	48	enzyme	enzyme	NN
cord-015684-q10sx1dm	447	49	.	.	.
cord-015684-q10sx1dm	448	1	111	111	CD
cord-015684-q10sx1dm	449	1	Although	although	IN
cord-015684-q10sx1dm	449	2	most	most	JJS
cord-015684-q10sx1dm	449	3	studies	study	NNS
cord-015684-q10sx1dm	449	4	predict	predict	VBP
cord-015684-q10sx1dm	449	5	the	the	DT
cord-015684-q10sx1dm	449	6	safety	safety	NN
cord-015684-q10sx1dm	449	7	of	of	IN
cord-015684-q10sx1dm	449	8	donepezil	donepezil	NNP
cord-015684-q10sx1dm	449	9	112	112	CD
cord-015684-q10sx1dm	449	10	and	and	CC
cord-015684-q10sx1dm	449	11	galantamine	galantamine	NNP
cord-015684-q10sx1dm	449	12	,	,	,
cord-015684-q10sx1dm	449	13	107	107	CD
cord-015684-q10sx1dm	449	14	as	as	IN
cord-015684-q10sx1dm	449	15	the	the	DT
cord-015684-q10sx1dm	449	16	two	two	CD
cord-015684-q10sx1dm	449	17	principal	principal	JJ
cord-015684-q10sx1dm	449	18	cholinesterase	cholinesterase	NN
cord-015684-q10sx1dm	449	19	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	449	20	metabolized	metabolize	VBN
cord-015684-q10sx1dm	449	21	by	by	IN
cord-015684-q10sx1dm	449	22	CYP2D6-related	cyp2d6-related	JJ
cord-015684-q10sx1dm	449	23	enzymes	enzyme	NNS
cord-015684-q10sx1dm	449	24	,	,	,
cord-015684-q10sx1dm	449	25	113	113	CD
cord-015684-q10sx1dm	449	26	,	,	,
cord-015684-q10sx1dm	449	27	114	114	CD
cord-015684-q10sx1dm	449	28	no	no	DT
cord-015684-q10sx1dm	449	29	pharmacogenetic	pharmacogenetic	JJ
cord-015684-q10sx1dm	449	30	studies	study	NNS
cord-015684-q10sx1dm	449	31	have	have	VBP
cord-015684-q10sx1dm	449	32	been	be	VBN
cord-015684-q10sx1dm	449	33	performed	perform	VBN
cord-015684-q10sx1dm	449	34	so	so	RB
cord-015684-q10sx1dm	449	35	far	far	RB
cord-015684-q10sx1dm	449	36	on	on	IN
cord-015684-q10sx1dm	449	37	an	an	DT
cord-015684-q10sx1dm	449	38	individual	individual	JJ
cord-015684-q10sx1dm	449	39	basis	basis	NN
cord-015684-q10sx1dm	449	40	to	to	TO
cord-015684-q10sx1dm	449	41	personalize	personalize	VB
cord-015684-q10sx1dm	449	42	the	the	DT
cord-015684-q10sx1dm	449	43	treatment	treatment	NN
cord-015684-q10sx1dm	449	44	,	,	,
cord-015684-q10sx1dm	449	45	and	and	CC
cord-015684-q10sx1dm	449	46	most	most	JJS
cord-015684-q10sx1dm	449	47	studies	study	NNS
cord-015684-q10sx1dm	449	48	reporting	report	VBG
cord-015684-q10sx1dm	449	49	safety	safety	NN
cord-015684-q10sx1dm	449	50	issues	issue	NNS
cord-015684-q10sx1dm	449	51	are	be	VBP
cord-015684-q10sx1dm	449	52	the	the	DT
cord-015684-q10sx1dm	449	53	result	result	NN
cord-015684-q10sx1dm	449	54	of	of	IN
cord-015684-q10sx1dm	449	55	pooling	pool	VBG
cord-015684-q10sx1dm	449	56	together	together	RB
cord-015684-q10sx1dm	449	57	pharmacological	pharmacological	JJ
cord-015684-q10sx1dm	449	58	and	and	CC
cord-015684-q10sx1dm	449	59	clinical	clinical	JJ
cord-015684-q10sx1dm	449	60	information	information	NN
cord-015684-q10sx1dm	449	61	obtained	obtain	VBN
cord-015684-q10sx1dm	449	62	with	with	IN
cord-015684-q10sx1dm	449	63	routine	routine	JJ
cord-015684-q10sx1dm	449	64	procedures	procedure	NNS
cord-015684-q10sx1dm	449	65	.	.	.
cord-015684-q10sx1dm	450	1	103	103	CD
cord-015684-q10sx1dm	450	2	,	,	,
cord-015684-q10sx1dm	450	3	[	[	-LRB-
cord-015684-q10sx1dm	450	4	115	115	CD
cord-015684-q10sx1dm	450	5	]	]	-RRB-
cord-015684-q10sx1dm	450	6	[	[	-LRB-
cord-015684-q10sx1dm	450	7	116	116	CD
cord-015684-q10sx1dm	450	8	]	]	-RRB-
cord-015684-q10sx1dm	450	9	[	[	-LRB-
cord-015684-q10sx1dm	450	10	117	117	CD
cord-015684-q10sx1dm	450	11	]	]	-RRB-
cord-015684-q10sx1dm	451	1	In	in	IN
cord-015684-q10sx1dm	451	2	certain	certain	JJ
cord-015684-q10sx1dm	451	3	cases	case	NNS
cord-015684-q10sx1dm	451	4	,	,	,
cord-015684-q10sx1dm	451	5	genetic	genetic	JJ
cord-015684-q10sx1dm	451	6	polymorphism	polymorphism	NN
cord-015684-q10sx1dm	451	7	in	in	IN
cord-015684-q10sx1dm	451	8	the	the	DT
cord-015684-q10sx1dm	451	9	expression	expression	NN
cord-015684-q10sx1dm	451	10	of	of	IN
cord-015684-q10sx1dm	451	11	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	451	12	is	be	VBZ
cord-015684-q10sx1dm	451	13	not	not	RB
cord-015684-q10sx1dm	451	14	expected	expect	VBN
cord-015684-q10sx1dm	451	15	to	to	TO
cord-015684-q10sx1dm	451	16	affect	affect	VB
cord-015684-q10sx1dm	451	17	the	the	DT
cord-015684-q10sx1dm	451	18	pharmacodynamics	pharmacodynamic	NNS
cord-015684-q10sx1dm	451	19	of	of	IN
cord-015684-q10sx1dm	451	20	some	some	DT
cord-015684-q10sx1dm	451	21	cholinesterase	cholinesterase	NN
cord-015684-q10sx1dm	451	22	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	451	23	because	because	IN
cord-015684-q10sx1dm	451	24	major	major	JJ
cord-015684-q10sx1dm	451	25	meta	meta	JJ
cord-015684-q10sx1dm	451	26	-	-	HYPH
cord-015684-q10sx1dm	451	27	bolic	bolic	JJ
cord-015684-q10sx1dm	451	28	pathways	pathway	NNS
cord-015684-q10sx1dm	451	29	are	be	VBP
cord-015684-q10sx1dm	451	30	glucuronidation	glucuronidation	NN
cord-015684-q10sx1dm	451	31	,	,	,
cord-015684-q10sx1dm	451	32	O	o	NN
cord-015684-q10sx1dm	451	33	-	-	HYPH
cord-015684-q10sx1dm	451	34	demethylation	demethylation	NN
cord-015684-q10sx1dm	451	35	,	,	,
cord-015684-q10sx1dm	451	36	N	n	CD
cord-015684-q10sx1dm	451	37	-	-	HYPH
cord-015684-q10sx1dm	451	38	demethylation	demethylation	NNP
cord-015684-q10sx1dm	451	39	,	,	,
cord-015684-q10sx1dm	451	40	N	n	NN
cord-015684-q10sx1dm	451	41	-	-	HYPH
cord-015684-q10sx1dm	451	42	oxidation	oxidation	NN
cord-015684-q10sx1dm	451	43	,	,	,
cord-015684-q10sx1dm	451	44	and	and	CC
cord-015684-q10sx1dm	451	45	epimerization	epimerization	NN
cord-015684-q10sx1dm	451	46	.	.	.
cord-015684-q10sx1dm	452	1	However	however	RB
cord-015684-q10sx1dm	452	2	,	,	,
cord-015684-q10sx1dm	452	3	excretion	excretion	NN
cord-015684-q10sx1dm	452	4	rates	rate	NNS
cord-015684-q10sx1dm	452	5	are	be	VBP
cord-015684-q10sx1dm	452	6	substantially	substantially	RB
cord-015684-q10sx1dm	452	7	different	different	JJ
cord-015684-q10sx1dm	452	8	in	in	IN
cord-015684-q10sx1dm	452	9	EMs	EMs	NNP
cord-015684-q10sx1dm	452	10	and	and	CC
cord-015684-q10sx1dm	452	11	PMs	PMs	NNP
cord-015684-q10sx1dm	452	12	.	.	.
cord-015684-q10sx1dm	453	1	For	for	IN
cord-015684-q10sx1dm	453	2	instance	instance	NN
cord-015684-q10sx1dm	453	3	,	,	,
cord-015684-q10sx1dm	453	4	in	in	IN
cord-015684-q10sx1dm	453	5	EMs	EMs	NNP
cord-015684-q10sx1dm	453	6	,	,	,
cord-015684-q10sx1dm	453	7	urinary	urinary	JJ
cord-015684-q10sx1dm	453	8	metabolites	metabolite	NNS
cord-015684-q10sx1dm	453	9	resulting	result	VBG
cord-015684-q10sx1dm	453	10	from	from	IN
cord-015684-q10sx1dm	453	11	O	o	NN
cord-015684-q10sx1dm	453	12	-	-	HYPH
cord-015684-q10sx1dm	453	13	demethylation	demethylation	NN
cord-015684-q10sx1dm	453	14	of	of	IN
cord-015684-q10sx1dm	453	15	galantamine	galantamine	NNP
cord-015684-q10sx1dm	453	16	represent	represent	VBP
cord-015684-q10sx1dm	453	17	33.2	33.2	CD
cord-015684-q10sx1dm	453	18	%	%	NN
cord-015684-q10sx1dm	453	19	of	of	IN
cord-015684-q10sx1dm	453	20	the	the	DT
cord-015684-q10sx1dm	453	21	dose	dose	NN
cord-015684-q10sx1dm	453	22	compared	compare	VBN
cord-015684-q10sx1dm	453	23	with	with	IN
cord-015684-q10sx1dm	453	24	5.2	5.2	CD
cord-015684-q10sx1dm	453	25	%	%	NN
cord-015684-q10sx1dm	453	26	in	in	IN
cord-015684-q10sx1dm	453	27	PMs	pm	NNS
cord-015684-q10sx1dm	453	28	,	,	,
cord-015684-q10sx1dm	453	29	which	which	WDT
cord-015684-q10sx1dm	453	30	show	show	VBP
cord-015684-q10sx1dm	453	31	correspondingly	correspondingly	RB
cord-015684-q10sx1dm	453	32	higher	high	JJR
cord-015684-q10sx1dm	453	33	urinary	urinary	JJ
cord-015684-q10sx1dm	453	34	excretion	excretion	NN
cord-015684-q10sx1dm	453	35	of	of	IN
cord-015684-q10sx1dm	453	36	unchanged	unchanged	JJ
cord-015684-q10sx1dm	453	37	galantamine	galantamine	NNP
cord-015684-q10sx1dm	453	38	and	and	CC
cord-015684-q10sx1dm	453	39	its	-PRON-	PRP$
cord-015684-q10sx1dm	453	40	N	n	CD
cord-015684-q10sx1dm	453	41	-	-	HYPH
cord-015684-q10sx1dm	453	42	oxide	oxide	NN
cord-015684-q10sx1dm	453	43	.	.	.
cord-015684-q10sx1dm	454	1	118	118	CD
cord-015684-q10sx1dm	455	1	Therefore	therefore	RB
cord-015684-q10sx1dm	455	2	,	,	,
cord-015684-q10sx1dm	455	3	still	still	RB
cord-015684-q10sx1dm	455	4	there	there	EX
cord-015684-q10sx1dm	455	5	are	be	VBP
cord-015684-q10sx1dm	455	6	many	many	JJ
cord-015684-q10sx1dm	455	7	unanswered	unanswered	JJ
cord-015684-q10sx1dm	455	8	questions	question	NNS
cord-015684-q10sx1dm	455	9	regarding	regard	VBG
cord-015684-q10sx1dm	455	10	the	the	DT
cord-015684-q10sx1dm	455	11	metabolism	metabolism	NN
cord-015684-q10sx1dm	455	12	of	of	IN
cord-015684-q10sx1dm	455	13	cholinesterase	cholinesterase	NN
cord-015684-q10sx1dm	455	14	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	455	15	and	and	CC
cord-015684-q10sx1dm	455	16	their	-PRON-	PRP$
cord-015684-q10sx1dm	455	17	interaction	interaction	NN
cord-015684-q10sx1dm	455	18	with	with	IN
cord-015684-q10sx1dm	455	19	other	other	JJ
cord-015684-q10sx1dm	455	20	drugs	drug	NNS
cord-015684-q10sx1dm	455	21	(	(	-LRB-
cord-015684-q10sx1dm	455	22	potentially	potentially	RB
cord-015684-q10sx1dm	455	23	leading	lead	VBG
cord-015684-q10sx1dm	455	24	to	to	IN
cord-015684-q10sx1dm	455	25	ADRs	adr	NNS
cord-015684-q10sx1dm	455	26	)	)	-RRB-
cord-015684-q10sx1dm	455	27	which	which	WDT
cord-015684-q10sx1dm	455	28	require	require	VBP
cord-015684-q10sx1dm	455	29	pharmacogenetic	pharmacogenetic	JJ
cord-015684-q10sx1dm	455	30	elucidation	elucidation	NN
cord-015684-q10sx1dm	455	31	.	.	.
cord-015684-q10sx1dm	456	1	It	-PRON-	PRP
cord-015684-q10sx1dm	456	2	is	be	VBZ
cord-015684-q10sx1dm	456	3	also	also	RB
cord-015684-q10sx1dm	456	4	worth	worth	JJ
cord-015684-q10sx1dm	456	5	to	to	TO
cord-015684-q10sx1dm	456	6	mention	mention	VB
cord-015684-q10sx1dm	456	7	that	that	IN
cord-015684-q10sx1dm	456	8	dose	dose	NN
cord-015684-q10sx1dm	456	9	titration	titration	NN
cord-015684-q10sx1dm	456	10	(	(	-LRB-
cord-015684-q10sx1dm	456	11	a	a	DT
cord-015684-q10sx1dm	456	12	common	common	JJ
cord-015684-q10sx1dm	456	13	practice	practice	NN
cord-015684-q10sx1dm	456	14	in	in	IN
cord-015684-q10sx1dm	456	15	AD	ad	NN
cord-015684-q10sx1dm	456	16	patients	patient	NNS
cord-015684-q10sx1dm	456	17	treated	treat	VBN
cord-015684-q10sx1dm	456	18	with	with	IN
cord-015684-q10sx1dm	456	19	cholinesterase	cholinesterase	NN
cord-015684-q10sx1dm	456	20	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	456	21	;	;	:
cord-015684-q10sx1dm	456	22	e.g.	e.g.	RB
cord-015684-q10sx1dm	456	23	,	,	,
cord-015684-q10sx1dm	456	24	tacrine	tacrine	NNP
cord-015684-q10sx1dm	456	25	,	,	,
cord-015684-q10sx1dm	456	26	donepezil	donepezil	NNP
cord-015684-q10sx1dm	456	27	)	)	-RRB-
cord-015684-q10sx1dm	456	28	is	be	VBZ
cord-015684-q10sx1dm	456	29	an	an	DT
cord-015684-q10sx1dm	456	30	unwise	unwise	JJ
cord-015684-q10sx1dm	456	31	strategy	strategy	NN
cord-015684-q10sx1dm	456	32	,	,	,
cord-015684-q10sx1dm	456	33	since	since	IN
cord-015684-q10sx1dm	456	34	approximately	approximately	RB
cord-015684-q10sx1dm	456	35	30	30	CD
cord-015684-q10sx1dm	456	36	-	-	SYM
cord-015684-q10sx1dm	456	37	60	60	CD
cord-015684-q10sx1dm	456	38	%	%	NN
cord-015684-q10sx1dm	456	39	of	of	IN
cord-015684-q10sx1dm	456	40	drug	drug	NN
cord-015684-q10sx1dm	456	41	failure	failure	NN
cord-015684-q10sx1dm	456	42	or	or	CC
cord-015684-q10sx1dm	456	43	lack	lack	NN
cord-015684-q10sx1dm	456	44	of	of	IN
cord-015684-q10sx1dm	456	45	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	456	46	effi	effi	NNP
cord-015684-q10sx1dm	456	47	cacy	cacy	NN
cord-015684-q10sx1dm	456	48	(	(	-LRB-
cord-015684-q10sx1dm	456	49	and/or	and/or	CC
cord-015684-q10sx1dm	456	50	ADR	ADR	NNP
cord-015684-q10sx1dm	456	51	manifestation	manifestation	NN
cord-015684-q10sx1dm	456	52	)	)	-RRB-
cord-015684-q10sx1dm	456	53	is	be	VBZ
cord-015684-q10sx1dm	456	54	not	not	RB
cord-015684-q10sx1dm	456	55	a	a	DT
cord-015684-q10sx1dm	456	56	matter	matter	NN
cord-015684-q10sx1dm	456	57	of	of	IN
cord-015684-q10sx1dm	456	58	drug	drug	NN
cord-015684-q10sx1dm	456	59	dosage	dosage	NN
cord-015684-q10sx1dm	456	60	but	but	CC
cord-015684-q10sx1dm	456	61	a	a	DT
cord-015684-q10sx1dm	456	62	problem	problem	NN
cord-015684-q10sx1dm	456	63	of	of	IN
cord-015684-q10sx1dm	456	64	poor	poor	JJ
cord-015684-q10sx1dm	456	65	metabolizing	metabolize	VBG
cord-015684-q10sx1dm	456	66	capacity	capacity	NN
cord-015684-q10sx1dm	456	67	in	in	IN
cord-015684-q10sx1dm	456	68	PMs	pm	NNS
cord-015684-q10sx1dm	456	69	.	.	.
cord-015684-q10sx1dm	457	1	Additionally	additionally	RB
cord-015684-q10sx1dm	457	2	,	,	,
cord-015684-q10sx1dm	457	3	inappropriate	inappropriate	JJ
cord-015684-q10sx1dm	457	4	drug	drug	NN
cord-015684-q10sx1dm	457	5	use	use	NN
cord-015684-q10sx1dm	457	6	is	be	VBZ
cord-015684-q10sx1dm	457	7	one	one	CD
cord-015684-q10sx1dm	457	8	of	of	IN
cord-015684-q10sx1dm	457	9	the	the	DT
cord-015684-q10sx1dm	457	10	risk	risk	NN
cord-015684-q10sx1dm	457	11	factors	factor	NNS
cord-015684-q10sx1dm	457	12	for	for	IN
cord-015684-q10sx1dm	457	13	adverse	adverse	JJ
cord-015684-q10sx1dm	457	14	drug	drug	NN
cord-015684-q10sx1dm	457	15	reactions	reaction	NNS
cord-015684-q10sx1dm	457	16	(	(	-LRB-
cord-015684-q10sx1dm	457	17	ADRs	adr	NNS
cord-015684-q10sx1dm	457	18	)	)	-RRB-
cord-015684-q10sx1dm	457	19	in	in	IN
cord-015684-q10sx1dm	457	20	the	the	DT
cord-015684-q10sx1dm	457	21	elderly	elderly	JJ
cord-015684-q10sx1dm	457	22	.	.	.
cord-015684-q10sx1dm	458	1	The	the	DT
cord-015684-q10sx1dm	458	2	prevalence	prevalence	NN
cord-015684-q10sx1dm	458	3	of	of	IN
cord-015684-q10sx1dm	458	4	use	use	NN
cord-015684-q10sx1dm	458	5	of	of	IN
cord-015684-q10sx1dm	458	6	potentially	potentially	RB
cord-015684-q10sx1dm	458	7	inappropriate	inappropriate	JJ
cord-015684-q10sx1dm	458	8	medications	medication	NNS
cord-015684-q10sx1dm	458	9	in	in	IN
cord-015684-q10sx1dm	458	10	patients	patient	NNS
cord-015684-q10sx1dm	458	11	older	old	JJR
cord-015684-q10sx1dm	458	12	than	than	IN
cord-015684-q10sx1dm	458	13	65	65	CD
cord-015684-q10sx1dm	458	14	years	year	NNS
cord-015684-q10sx1dm	458	15	of	of	IN
cord-015684-q10sx1dm	458	16	age	age	NN
cord-015684-q10sx1dm	458	17	admitted	admit	VBD
cord-015684-q10sx1dm	458	18	to	to	IN
cord-015684-q10sx1dm	458	19	a	a	DT
cord-015684-q10sx1dm	458	20	general	general	JJ
cord-015684-q10sx1dm	458	21	medical	medical	JJ
cord-015684-q10sx1dm	458	22	or	or	CC
cord-015684-q10sx1dm	458	23	geriatric	geriatric	JJ
cord-015684-q10sx1dm	458	24	ward	ward	NN
cord-015684-q10sx1dm	458	25	ranges	range	VBZ
cord-015684-q10sx1dm	458	26	from	from	IN
cord-015684-q10sx1dm	458	27	16	16	CD
cord-015684-q10sx1dm	458	28	%	%	NN
cord-015684-q10sx1dm	458	29	to	to	TO
cord-015684-q10sx1dm	458	30	20	20	CD
cord-015684-q10sx1dm	458	31	%	%	NN
cord-015684-q10sx1dm	458	32	,	,	,
cord-015684-q10sx1dm	458	33	119	119	CD
cord-015684-q10sx1dm	458	34	and	and	CC
cord-015684-q10sx1dm	458	35	these	these	DT
cord-015684-q10sx1dm	458	36	numbers	number	NNS
cord-015684-q10sx1dm	458	37	may	may	MD
cord-015684-q10sx1dm	458	38	double	double	VB
cord-015684-q10sx1dm	458	39	in	in	IN
cord-015684-q10sx1dm	458	40	ambulatory	ambulatory	JJ
cord-015684-q10sx1dm	458	41	patients	patient	NNS
cord-015684-q10sx1dm	458	42	.	.	.
cord-015684-q10sx1dm	459	1	Overall	overall	RB
cord-015684-q10sx1dm	459	2	,	,	,
cord-015684-q10sx1dm	459	3	the	the	DT
cord-015684-q10sx1dm	459	4	most	most	RBS
cord-015684-q10sx1dm	459	5	prevalent	prevalent	JJ
cord-015684-q10sx1dm	459	6	inappropriate	inappropriate	JJ
cord-015684-q10sx1dm	459	7	drugs	drug	NNS
cord-015684-q10sx1dm	459	8	currently	currently	RB
cord-015684-q10sx1dm	459	9	prescribed	prescribe	VBN
cord-015684-q10sx1dm	459	10	to	to	IN
cord-015684-q10sx1dm	459	11	the	the	DT
cord-015684-q10sx1dm	459	12	elderly	elderly	JJ
cord-015684-q10sx1dm	459	13	are	be	VBP
cord-015684-q10sx1dm	459	14	amiodarone	amiodarone	NN
cord-015684-q10sx1dm	459	15	,	,	,
cord-015684-q10sx1dm	459	16	long	long	RB
cord-015684-q10sx1dm	459	17	-	-	HYPH
cord-015684-q10sx1dm	459	18	acting	act	VBG
cord-015684-q10sx1dm	459	19	benzodiazepines	benzodiazepine	NNS
cord-015684-q10sx1dm	459	20	and	and	CC
cord-015684-q10sx1dm	459	21	anticholinergic	anticholinergic	JJ
cord-015684-q10sx1dm	459	22	antispasmodics	antispasmodic	NNS
cord-015684-q10sx1dm	459	23	;	;	:
cord-015684-q10sx1dm	459	24	however	however	RB
cord-015684-q10sx1dm	459	25	,	,	,
cord-015684-q10sx1dm	459	26	the	the	DT
cord-015684-q10sx1dm	459	27	list	list	NN
cord-015684-q10sx1dm	459	28	of	of	IN
cord-015684-q10sx1dm	459	29	drugs	drug	NNS
cord-015684-q10sx1dm	459	30	with	with	IN
cord-015684-q10sx1dm	459	31	potential	potential	JJ
cord-015684-q10sx1dm	459	32	risk	risk	NN
cord-015684-q10sx1dm	459	33	also	also	RB
cord-015684-q10sx1dm	459	34	include	include	VBP
cord-015684-q10sx1dm	459	35	antidepressant	antidepressant	NN
cord-015684-q10sx1dm	459	36	,	,	,
cord-015684-q10sx1dm	459	37	antihistaminics	antihistaminic	NNS
cord-015684-q10sx1dm	459	38	,	,	,
cord-015684-q10sx1dm	459	39	NSAIDs	nsaid	NNS
cord-015684-q10sx1dm	459	40	,	,	,
cord-015684-q10sx1dm	459	41	amphetamines	amphetamine	NNS
cord-015684-q10sx1dm	459	42	,	,	,
cord-015684-q10sx1dm	459	43	laxatives	laxative	NNS
cord-015684-q10sx1dm	459	44	,	,	,
cord-015684-q10sx1dm	459	45	clonidine	clonidine	NN
cord-015684-q10sx1dm	459	46	,	,	,
cord-015684-q10sx1dm	459	47	indomethacin	indomethacin	NN
cord-015684-q10sx1dm	459	48	,	,	,
cord-015684-q10sx1dm	459	49	and	and	CC
cord-015684-q10sx1dm	459	50	several	several	JJ
cord-015684-q10sx1dm	459	51	neuroleptics	neuroleptic	NNS
cord-015684-q10sx1dm	459	52	,	,	,
cord-015684-q10sx1dm	459	53	119	119	CD
cord-015684-q10sx1dm	459	54	most	most	JJS
cord-015684-q10sx1dm	459	55	of	of	IN
cord-015684-q10sx1dm	459	56	which	which	WDT
cord-015684-q10sx1dm	459	57	are	be	VBP
cord-015684-q10sx1dm	459	58	processed	process	VBN
cord-015684-q10sx1dm	459	59	via	via	IN
cord-015684-q10sx1dm	459	60	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	459	61	and	and	CC
cord-015684-q10sx1dm	459	62	CYP3A5	CYP3A5	NNP
cord-015684-q10sx1dm	459	63	enzymes	enzyme	NNS
cord-015684-q10sx1dm	459	64	.	.	.
cord-015684-q10sx1dm	460	1	120	120	CD
cord-015684-q10sx1dm	461	1	Therefore	therefore	RB
cord-015684-q10sx1dm	461	2	,	,	,
cord-015684-q10sx1dm	461	3	pre	pre	JJ
cord-015684-q10sx1dm	461	4	-	-	JJ
cord-015684-q10sx1dm	461	5	treatment	treatment	JJ
cord-015684-q10sx1dm	461	6	CYP	CYP	NNP
cord-015684-q10sx1dm	461	7	screening	screening	NN
cord-015684-q10sx1dm	461	8	might	may	MD
cord-015684-q10sx1dm	461	9	be	be	VB
cord-015684-q10sx1dm	461	10	of	of	IN
cord-015684-q10sx1dm	461	11	great	great	JJ
cord-015684-q10sx1dm	461	12	help	help	NN
cord-015684-q10sx1dm	461	13	to	to	TO
cord-015684-q10sx1dm	461	14	rationalize	rationalize	VB
cord-015684-q10sx1dm	461	15	and	and	CC
cord-015684-q10sx1dm	461	16	optimize	optimize	VB
cord-015684-q10sx1dm	461	17	therapeutics	therapeutic	NNS
cord-015684-q10sx1dm	461	18	in	in	IN
cord-015684-q10sx1dm	461	19	the	the	DT
cord-015684-q10sx1dm	461	20	elderly	elderly	JJ
cord-015684-q10sx1dm	461	21	,	,	,
cord-015684-q10sx1dm	461	22	by	by	IN
cord-015684-q10sx1dm	461	23	avoiding	avoid	VBG
cord-015684-q10sx1dm	461	24	medications	medication	NNS
cord-015684-q10sx1dm	461	25	of	of	IN
cord-015684-q10sx1dm	461	26	risk	risk	NN
cord-015684-q10sx1dm	461	27	in	in	IN
cord-015684-q10sx1dm	461	28	PMs	PMs	NNP
cord-015684-q10sx1dm	461	29	and	and	CC
cord-015684-q10sx1dm	461	30	UMs	um	NNS
cord-015684-q10sx1dm	461	31	.	.	.
cord-015684-q10sx1dm	462	1	There	there	EX
cord-015684-q10sx1dm	462	2	are	be	VBP
cord-015684-q10sx1dm	462	3	substantial	substantial	JJ
cord-015684-q10sx1dm	462	4	differences	difference	NNS
cord-015684-q10sx1dm	462	5	between	between	IN
cord-015684-q10sx1dm	462	6	individuals	individual	NNS
cord-015684-q10sx1dm	462	7	in	in	IN
cord-015684-q10sx1dm	462	8	the	the	DT
cord-015684-q10sx1dm	462	9	effects	effect	NNS
cord-015684-q10sx1dm	462	10	of	of	IN
cord-015684-q10sx1dm	462	11	psychotropic	psychotropic	JJ
cord-015684-q10sx1dm	462	12	drugs	drug	NNS
cord-015684-q10sx1dm	462	13	in	in	IN
cord-015684-q10sx1dm	462	14	the	the	DT
cord-015684-q10sx1dm	462	15	treatment	treatment	NN
cord-015684-q10sx1dm	462	16	of	of	IN
cord-015684-q10sx1dm	462	17	neuropsychiatric	neuropsychiatric	JJ
cord-015684-q10sx1dm	462	18	disorders	disorder	NNS
cord-015684-q10sx1dm	462	19	.	.	.
cord-015684-q10sx1dm	463	1	Pharmacogenetic	pharmacogenetic	JJ
cord-015684-q10sx1dm	463	2	studies	study	NNS
cord-015684-q10sx1dm	463	3	of	of	IN
cord-015684-q10sx1dm	463	4	psychotropic	psychotropic	JJ
cord-015684-q10sx1dm	463	5	drug	drug	NN
cord-015684-q10sx1dm	463	6	response	response	NN
cord-015684-q10sx1dm	463	7	have	have	VBP
cord-015684-q10sx1dm	463	8	focused	focus	VBN
cord-015684-q10sx1dm	463	9	on	on	IN
cord-015684-q10sx1dm	463	10	determining	determine	VBG
cord-015684-q10sx1dm	463	11	the	the	DT
cord-015684-q10sx1dm	463	12	relationship	relationship	NN
cord-015684-q10sx1dm	463	13	between	between	IN
cord-015684-q10sx1dm	463	14	variation	variation	NN
cord-015684-q10sx1dm	463	15	in	in	IN
cord-015684-q10sx1dm	463	16	specifi	specifi	NNP
cord-015684-q10sx1dm	463	17	c	c	NNP
cord-015684-q10sx1dm	463	18	candidate	candidate	NN
cord-015684-q10sx1dm	463	19	genes	gene	NNS
cord-015684-q10sx1dm	463	20	and	and	CC
cord-015684-q10sx1dm	463	21	the	the	DT
cord-015684-q10sx1dm	463	22	positive	positive	JJ
cord-015684-q10sx1dm	463	23	and	and	CC
cord-015684-q10sx1dm	463	24	adverse	adverse	JJ
cord-015684-q10sx1dm	463	25	effects	effect	NNS
cord-015684-q10sx1dm	463	26	of	of	IN
cord-015684-q10sx1dm	463	27	drug	drug	NN
cord-015684-q10sx1dm	463	28	treatment	treatment	NN
cord-015684-q10sx1dm	463	29	.	.	.
cord-015684-q10sx1dm	464	1	121	121	CD
cord-015684-q10sx1dm	464	2	More	More	JJR
cord-015684-q10sx1dm	464	3	than	than	IN
cord-015684-q10sx1dm	464	4	200	200	CD
cord-015684-q10sx1dm	464	5	different	different	JJ
cord-015684-q10sx1dm	464	6	genes	gene	NNS
cord-015684-q10sx1dm	464	7	are	be	VBP
cord-015684-q10sx1dm	464	8	potentially	potentially	RB
cord-015684-q10sx1dm	464	9	involved	involved	JJ
cord-015684-q10sx1dm	464	10	in	in	IN
cord-015684-q10sx1dm	464	11	the	the	DT
cord-015684-q10sx1dm	464	12	metabolism	metabolism	NN
cord-015684-q10sx1dm	464	13	of	of	IN
cord-015684-q10sx1dm	464	14	psychotropic	psychotropic	JJ
cord-015684-q10sx1dm	464	15	drugs	drug	NNS
cord-015684-q10sx1dm	464	16	infl	infl	NNP
cord-015684-q10sx1dm	464	17	uencing	uencing	NNP
cord-015684-q10sx1dm	464	18	pharmacokinetics	pharmacokinetic	NNS
cord-015684-q10sx1dm	464	19	and	and	CC
cord-015684-q10sx1dm	464	20	pharmacodynamics	pharmacodynamic	NNS
cord-015684-q10sx1dm	464	21	.	.	.
cord-015684-q10sx1dm	465	1	Of	of	IN
cord-015684-q10sx1dm	465	2	all	all	DT
cord-015684-q10sx1dm	465	3	genes	gene	NNS
cord-015684-q10sx1dm	465	4	affecting	affect	VBG
cord-015684-q10sx1dm	465	5	drug	drug	NN
cord-015684-q10sx1dm	465	6	metabolism	metabolism	NN
cord-015684-q10sx1dm	465	7	,	,	,
cord-015684-q10sx1dm	465	8	effi	effi	NNP
cord-015684-q10sx1dm	465	9	cacy	cacy	NNP
cord-015684-q10sx1dm	465	10	and	and	CC
cord-015684-q10sx1dm	465	11	safety	safety	NN
cord-015684-q10sx1dm	465	12	,	,	,
cord-015684-q10sx1dm	465	13	the	the	DT
cord-015684-q10sx1dm	465	14	CYP	CYP	NNP
cord-015684-q10sx1dm	465	15	gene	gene	NN
cord-015684-q10sx1dm	465	16	family	family	NN
cord-015684-q10sx1dm	465	17	is	be	VBZ
cord-015684-q10sx1dm	465	18	the	the	DT
cord-015684-q10sx1dm	465	19	most	most	RBS
cord-015684-q10sx1dm	465	20	relevant	relevant	JJ
cord-015684-q10sx1dm	465	21	since	since	IN
cord-015684-q10sx1dm	465	22	more	more	JJR
cord-015684-q10sx1dm	465	23	than	than	IN
cord-015684-q10sx1dm	465	24	60	60	CD
cord-015684-q10sx1dm	465	25	%	%	NN
cord-015684-q10sx1dm	465	26	of	of	IN
cord-015684-q10sx1dm	465	27	CNS	CNS	NNP
cord-015684-q10sx1dm	465	28	drugs	drug	NNS
cord-015684-q10sx1dm	465	29	are	be	VBP
cord-015684-q10sx1dm	465	30	metabolized	metabolize	VBN
cord-015684-q10sx1dm	465	31	by	by	IN
cord-015684-q10sx1dm	465	32	cytochrome	cytochrome	NN
cord-015684-q10sx1dm	465	33	P450	p450	JJ
cord-015684-q10sx1dm	465	34	enzymes	enzyme	NNS
cord-015684-q10sx1dm	465	35	.	.	.
cord-015684-q10sx1dm	466	1	[	[	-LRB-
cord-015684-q10sx1dm	466	2	122	122	CD
cord-015684-q10sx1dm	466	3	]	]	-RRB-
cord-015684-q10sx1dm	466	4	[	[	-LRB-
cord-015684-q10sx1dm	466	5	123	123	CD
cord-015684-q10sx1dm	466	6	]	]	-RRB-
cord-015684-q10sx1dm	467	1	[	[	-LRB-
cord-015684-q10sx1dm	467	2	124	124	CD
cord-015684-q10sx1dm	467	3	]	]	-RRB-
cord-015684-q10sx1dm	468	1	Approximately	approximately	RB
cord-015684-q10sx1dm	468	2	,	,	,
cord-015684-q10sx1dm	468	3	18	18	CD
cord-015684-q10sx1dm	468	4	%	%	NN
cord-015684-q10sx1dm	468	5	of	of	IN
cord-015684-q10sx1dm	468	6	neuroleptics	neuroleptic	NNS
cord-015684-q10sx1dm	468	7	are	be	VBP
cord-015684-q10sx1dm	468	8	major	major	JJ
cord-015684-q10sx1dm	468	9	substrates	substrate	NNS
cord-015684-q10sx1dm	468	10	of	of	IN
cord-015684-q10sx1dm	468	11	CYP1A2	CYP1A2	NNP
cord-015684-q10sx1dm	468	12	enzymes	enzyme	NNS
cord-015684-q10sx1dm	468	13	,	,	,
cord-015684-q10sx1dm	468	14	40	40	CD
cord-015684-q10sx1dm	468	15	%	%	NN
cord-015684-q10sx1dm	468	16	of	of	IN
cord-015684-q10sx1dm	468	17	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	468	18	,	,	,
cord-015684-q10sx1dm	468	19	and	and	CC
cord-015684-q10sx1dm	468	20	23	23	CD
cord-015684-q10sx1dm	468	21	%	%	NN
cord-015684-q10sx1dm	468	22	of	of	IN
cord-015684-q10sx1dm	468	23	CYP3A4	CYP3A4	NNP
cord-015684-q10sx1dm	468	24	;	;	:
cord-015684-q10sx1dm	468	25	24	24	CD
cord-015684-q10sx1dm	468	26	%	%	NN
cord-015684-q10sx1dm	468	27	of	of	IN
cord-015684-q10sx1dm	468	28	antidepressants	antidepressant	NNS
cord-015684-q10sx1dm	468	29	are	be	VBP
cord-015684-q10sx1dm	468	30	major	major	JJ
cord-015684-q10sx1dm	468	31	substrates	substrate	NNS
cord-015684-q10sx1dm	468	32	of	of	IN
cord-015684-q10sx1dm	468	33	CYP1A2	CYP1A2	NNP
cord-015684-q10sx1dm	468	34	enzymes	enzyme	NNS
cord-015684-q10sx1dm	468	35	,	,	,
cord-015684-q10sx1dm	468	36	5	5	CD
cord-015684-q10sx1dm	468	37	%	%	NN
cord-015684-q10sx1dm	468	38	of	of	IN
cord-015684-q10sx1dm	468	39	CYP2B6	CYP2B6	NNP
cord-015684-q10sx1dm	468	40	,	,	,
cord-015684-q10sx1dm	468	41	38	38	CD
cord-015684-q10sx1dm	468	42	%	%	NN
cord-015684-q10sx1dm	468	43	of	of	IN
cord-015684-q10sx1dm	468	44	CYP2C19	CYP2C19	NNP
cord-015684-q10sx1dm	468	45	,	,	,
cord-015684-q10sx1dm	468	46	85	85	CD
cord-015684-q10sx1dm	468	47	%	%	NN
cord-015684-q10sx1dm	468	48	of	of	IN
cord-015684-q10sx1dm	468	49	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	468	50	,	,	,
cord-015684-q10sx1dm	468	51	and	and	CC
cord-015684-q10sx1dm	468	52	38	38	CD
cord-015684-q10sx1dm	468	53	%	%	NN
cord-015684-q10sx1dm	468	54	of	of	IN
cord-015684-q10sx1dm	468	55	CYP3A4	CYP3A4	NNP
cord-015684-q10sx1dm	468	56	;	;	:
cord-015684-q10sx1dm	468	57	7	7	CD
cord-015684-q10sx1dm	468	58	%	%	NN
cord-015684-q10sx1dm	468	59	of	of	IN
cord-015684-q10sx1dm	468	60	benzodiazepines	benzodiazepine	NNS
cord-015684-q10sx1dm	468	61	are	be	VBP
cord-015684-q10sx1dm	468	62	major	major	JJ
cord-015684-q10sx1dm	468	63	substrates	substrate	NNS
cord-015684-q10sx1dm	468	64	of	of	IN
cord-015684-q10sx1dm	468	65	CYP2C19	CYP2C19	NNP
cord-015684-q10sx1dm	468	66	enzymes	enzyme	NNS
cord-015684-q10sx1dm	468	67	,	,	,
cord-015684-q10sx1dm	468	68	20	20	CD
cord-015684-q10sx1dm	468	69	%	%	NN
cord-015684-q10sx1dm	468	70	of	of	IN
cord-015684-q10sx1dm	468	71	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	468	72	,	,	,
cord-015684-q10sx1dm	468	73	and	and	CC
cord-015684-q10sx1dm	468	74	95	95	CD
cord-015684-q10sx1dm	468	75	%	%	NN
cord-015684-q10sx1dm	468	76	of	of	IN
cord-015684-q10sx1dm	468	77	CYP3A4	CYP3A4	NNP
cord-015684-q10sx1dm	468	78	(	(	-LRB-
cord-015684-q10sx1dm	468	79	Table	table	NN
cord-015684-q10sx1dm	468	80	40	40	CD
cord-015684-q10sx1dm	468	81	.5	.5	CD
cord-015684-q10sx1dm	468	82	)	)	-RRB-
cord-015684-q10sx1dm	468	83	.	.	.
cord-015684-q10sx1dm	469	1	Approximately	approximately	RB
cord-015684-q10sx1dm	469	2	,	,	,
cord-015684-q10sx1dm	469	3	80	80	CD
cord-015684-q10sx1dm	469	4	%	%	NN
cord-015684-q10sx1dm	469	5	of	of	IN
cord-015684-q10sx1dm	469	6	patients	patient	NNS
cord-015684-q10sx1dm	469	7	with	with	IN
cord-015684-q10sx1dm	469	8	resistant	resistant	JJ
cord-015684-q10sx1dm	469	9	depression	depression	NN
cord-015684-q10sx1dm	469	10	,	,	,
cord-015684-q10sx1dm	469	11	60	60	CD
cord-015684-q10sx1dm	469	12	%	%	NN
cord-015684-q10sx1dm	469	13	of	of	IN
cord-015684-q10sx1dm	469	14	patients	patient	NNS
cord-015684-q10sx1dm	469	15	non	non	JJ
cord-015684-q10sx1dm	469	16	-	-	JJ
cord-015684-q10sx1dm	469	17	responsive	responsive	JJ
cord-015684-q10sx1dm	469	18	to	to	IN
cord-015684-q10sx1dm	469	19	neuroleptics	neuroleptic	NNS
cord-015684-q10sx1dm	469	20	,	,	,
cord-015684-q10sx1dm	469	21	and	and	CC
cord-015684-q10sx1dm	469	22	50	50	CD
cord-015684-q10sx1dm	469	23	-	-	SYM
cord-015684-q10sx1dm	469	24	70	70	CD
cord-015684-q10sx1dm	469	25	%	%	NN
cord-015684-q10sx1dm	469	26	of	of	IN
cord-015684-q10sx1dm	469	27	patients	patient	NNS
cord-015684-q10sx1dm	469	28	with	with	IN
cord-015684-q10sx1dm	469	29	paradoxical	paradoxical	JJ
cord-015684-q10sx1dm	469	30	responses	response	NNS
cord-015684-q10sx1dm	469	31	to	to	IN
cord-015684-q10sx1dm	469	32	benzodiazepines	benzodiazepine	NNS
cord-015684-q10sx1dm	469	33	are	be	VBP
cord-015684-q10sx1dm	469	34	carriers	carrier	NNS
cord-015684-q10sx1dm	469	35	of	of	IN
cord-015684-q10sx1dm	469	36	mutant	mutant	JJ
cord-015684-q10sx1dm	469	37	variants	variant	NNS
cord-015684-q10sx1dm	469	38	of	of	IN
cord-015684-q10sx1dm	469	39	the	the	DT
cord-015684-q10sx1dm	469	40	CYP2D6	CYP2D6	NNPS
cord-015684-q10sx1dm	469	41	,	,	,
cord-015684-q10sx1dm	469	42	CYP2C9	CYP2C9	NNP
cord-015684-q10sx1dm	469	43	and	and	CC
cord-015684-q10sx1dm	469	44	CYP3A4	cyp3a4	JJ
cord-015684-q10sx1dm	469	45	genes	gene	NNS
cord-015684-q10sx1dm	469	46	,	,	,
cord-015684-q10sx1dm	469	47	falling	fall	VBG
cord-015684-q10sx1dm	469	48	within	within	IN
cord-015684-q10sx1dm	469	49	the	the	DT
cord-015684-q10sx1dm	469	50	categories	category	NNS
cord-015684-q10sx1dm	469	51	of	of	IN
cord-015684-q10sx1dm	469	52	poor	poor	JJ
cord-015684-q10sx1dm	469	53	or	or	CC
cord-015684-q10sx1dm	469	54	ultra	ultra	JJ
cord-015684-q10sx1dm	469	55	-	-	JJ
cord-015684-q10sx1dm	469	56	rapid	rapid	JJ
cord-015684-q10sx1dm	469	57	metabolizers	metabolizer	NNS
cord-015684-q10sx1dm	469	58	.	.	.
cord-015684-q10sx1dm	470	1	Other	other	JJ
cord-015684-q10sx1dm	470	2	genes	gene	NNS
cord-015684-q10sx1dm	470	3	infl	infl	VBP
cord-015684-q10sx1dm	470	4	uencing	uencing	JJ
cord-015684-q10sx1dm	470	5	psychotropic	psychotropic	JJ
cord-015684-q10sx1dm	470	6	drug	drug	NN
cord-015684-q10sx1dm	470	7	activity	activity	NN
cord-015684-q10sx1dm	470	8	include	include	VBP
cord-015684-q10sx1dm	470	9	the	the	DT
cord-015684-q10sx1dm	470	10	following	follow	VBG
cord-015684-q10sx1dm	470	11	:	:	:
cord-015684-q10sx1dm	470	12	ABCB1	ABCB1	NNP
cord-015684-q10sx1dm	470	13	(	(	-LRB-
cord-015684-q10sx1dm	470	14	[	[	-LRB-
cord-015684-q10sx1dm	470	15	128	128	CD
cord-015684-q10sx1dm	470	16	]	]	-RRB-
cord-015684-q10sx1dm	470	17	[	[	-LRB-
cord-015684-q10sx1dm	470	18	129	129	CD
cord-015684-q10sx1dm	470	19	]	]	-RRB-
cord-015684-q10sx1dm	470	20	[	[	-LRB-
cord-015684-q10sx1dm	470	21	130	130	CD
cord-015684-q10sx1dm	470	22	]	]	-RRB-
cord-015684-q10sx1dm	470	23	[	[	-LRB-
cord-015684-q10sx1dm	470	24	131	131	CD
cord-015684-q10sx1dm	470	25	]	]	-RRB-
cord-015684-q10sx1dm	470	26	[	[	-LRB-
cord-015684-q10sx1dm	470	27	132	132	CD
cord-015684-q10sx1dm	470	28	]	]	-RRB-
cord-015684-q10sx1dm	470	29	[	[	-LRB-
cord-015684-q10sx1dm	470	30	133	133	CD
cord-015684-q10sx1dm	470	31	]	]	-RRB-
cord-015684-q10sx1dm	470	32	[	[	-LRB-
cord-015684-q10sx1dm	470	33	134	134	CD
cord-015684-q10sx1dm	470	34	]	]	-RRB-
cord-015684-q10sx1dm	470	35	[	[	-LRB-
cord-015684-q10sx1dm	470	36	135	135	CD
cord-015684-q10sx1dm	470	37	]	]	-RRB-
cord-015684-q10sx1dm	470	38	[	[	-LRB-
cord-015684-q10sx1dm	470	39	136	136	CD
cord-015684-q10sx1dm	470	40	]	]	-RRB-
cord-015684-q10sx1dm	470	41	[	[	-LRB-
cord-015684-q10sx1dm	470	42	137	137	CD
cord-015684-q10sx1dm	470	43	]	]	-RRB-
cord-015684-q10sx1dm	470	44	[	[	-LRB-
cord-015684-q10sx1dm	470	45	138	138	CD
cord-015684-q10sx1dm	470	46	]	]	-RRB-
cord-015684-q10sx1dm	470	47	(	(	-LRB-
cord-015684-q10sx1dm	470	48	Table	table	NN
cord-015684-q10sx1dm	470	49	40.5	40.5	CD
cord-015684-q10sx1dm	470	50	)	)	-RRB-
cord-015684-q10sx1dm	470	51	.	.	.
cord-015684-q10sx1dm	471	1	Historically	historically	RB
cord-015684-q10sx1dm	471	2	,	,	,
cord-015684-q10sx1dm	471	3	the	the	DT
cord-015684-q10sx1dm	471	4	vast	vast	JJ
cord-015684-q10sx1dm	471	5	majority	majority	NN
cord-015684-q10sx1dm	471	6	of	of	IN
cord-015684-q10sx1dm	471	7	pharmacogenetic	pharmacogenetic	JJ
cord-015684-q10sx1dm	471	8	studies	study	NNS
cord-015684-q10sx1dm	471	9	of	of	IN
cord-015684-q10sx1dm	471	10	CNS	CNS	NNP
cord-015684-q10sx1dm	471	11	disorders	disorder	NNS
cord-015684-q10sx1dm	471	12	have	have	VBP
cord-015684-q10sx1dm	471	13	been	be	VBN
cord-015684-q10sx1dm	471	14	addressed	address	VBN
cord-015684-q10sx1dm	471	15	to	to	TO
cord-015684-q10sx1dm	471	16	evaluate	evaluate	VB
cord-015684-q10sx1dm	471	17	the	the	DT
cord-015684-q10sx1dm	471	18	impact	impact	NN
cord-015684-q10sx1dm	471	19	of	of	IN
cord-015684-q10sx1dm	471	20	cytochrome	cytochrome	NN
cord-015684-q10sx1dm	471	21	P450	p450	JJ
cord-015684-q10sx1dm	471	22	enzymes	enzyme	NNS
cord-015684-q10sx1dm	471	23	on	on	IN
cord-015684-q10sx1dm	471	24	drug	drug	NN
cord-015684-q10sx1dm	471	25	metabolism	metabolism	NN
cord-015684-q10sx1dm	471	26	.	.	.
cord-015684-q10sx1dm	472	1	[	[	-LRB-
cord-015684-q10sx1dm	472	2	125	125	CD
cord-015684-q10sx1dm	472	3	]	]	-RRB-
cord-015684-q10sx1dm	472	4	[	[	-LRB-
cord-015684-q10sx1dm	472	5	126	126	CD
cord-015684-q10sx1dm	472	6	]	]	-RRB-
cord-015684-q10sx1dm	472	7	[	[	-LRB-
cord-015684-q10sx1dm	472	8	127	127	CD
cord-015684-q10sx1dm	472	9	]	]	-RRB-
cord-015684-q10sx1dm	473	1	Furthermore	furthermore	RB
cord-015684-q10sx1dm	473	2	,	,	,
cord-015684-q10sx1dm	473	3	conventional	conventional	JJ
cord-015684-q10sx1dm	473	4	targets	target	NNS
cord-015684-q10sx1dm	473	5	for	for	IN
cord-015684-q10sx1dm	473	6	psychotropic	psychotropic	JJ
cord-015684-q10sx1dm	473	7	drugs	drug	NNS
cord-015684-q10sx1dm	473	8	were	be	VBD
cord-015684-q10sx1dm	473	9	the	the	DT
cord-015684-q10sx1dm	473	10	neurotransmitters	neurotransmitter	NNS
cord-015684-q10sx1dm	473	11	dopamine	dopamine	NN
cord-015684-q10sx1dm	473	12	,	,	,
cord-015684-q10sx1dm	473	13	serotonin	serotonin	NN
cord-015684-q10sx1dm	473	14	,	,	,
cord-015684-q10sx1dm	473	15	noradrenaline	noradrenaline	NN
cord-015684-q10sx1dm	473	16	,	,	,
cord-015684-q10sx1dm	473	17	GABA	GABA	NNP
cord-015684-q10sx1dm	473	18	,	,	,
cord-015684-q10sx1dm	473	19	ion	ion	NN
cord-015684-q10sx1dm	473	20	channels	channel	NNS
cord-015684-q10sx1dm	473	21	,	,	,
cord-015684-q10sx1dm	473	22	acetylcholine	acetylcholine	NN
cord-015684-q10sx1dm	473	23	and	and	CC
cord-015684-q10sx1dm	473	24	their	-PRON-	PRP$
cord-015684-q10sx1dm	473	25	respective	respective	JJ
cord-015684-q10sx1dm	473	26	biosynthetic	biosynthetic	JJ
cord-015684-q10sx1dm	473	27	and	and	CC
cord-015684-q10sx1dm	473	28	catalyzing	catalyzing	JJ
cord-015684-q10sx1dm	473	29	enzymes	enzyme	NNS
cord-015684-q10sx1dm	473	30	,	,	,
cord-015684-q10sx1dm	473	31	receptors	receptor	NNS
cord-015684-q10sx1dm	473	32	and	and	CC
cord-015684-q10sx1dm	473	33	transporters	transporter	NNS
cord-015684-q10sx1dm	473	34	121	121	CD
cord-015684-q10sx1dm	473	35	;	;	:
cord-015684-q10sx1dm	473	36	however	however	RB
cord-015684-q10sx1dm	473	37	,	,	,
cord-015684-q10sx1dm	473	38	in	in	IN
cord-015684-q10sx1dm	473	39	the	the	DT
cord-015684-q10sx1dm	473	40	past	past	JJ
cord-015684-q10sx1dm	473	41	few	few	JJ
cord-015684-q10sx1dm	473	42	years	year	NNS
cord-015684-q10sx1dm	473	43	many	many	JJ
cord-015684-q10sx1dm	473	44	different	different	JJ
cord-015684-q10sx1dm	473	45	genes	gene	NNS
cord-015684-q10sx1dm	473	46	have	have	VBP
cord-015684-q10sx1dm	473	47	been	be	VBN
cord-015684-q10sx1dm	473	48	associated	associate	VBN
cord-015684-q10sx1dm	473	49	with	with	IN
cord-015684-q10sx1dm	473	50	both	both	DT
cord-015684-q10sx1dm	473	51	pathogenesis	pathogenesis	NN
cord-015684-q10sx1dm	473	52	and	and	CC
cord-015684-q10sx1dm	473	53	pharmacogenomics	pharmacogenomic	NNS
cord-015684-q10sx1dm	473	54	of	of	IN
cord-015684-q10sx1dm	473	55	neuropsychiatric	neuropsychiatric	JJ
cord-015684-q10sx1dm	473	56	disorders	disorder	NNS
cord-015684-q10sx1dm	473	57	.	.	.
cord-015684-q10sx1dm	474	1	Some	some	DT
cord-015684-q10sx1dm	474	2	of	of	IN
cord-015684-q10sx1dm	474	3	these	these	DT
cord-015684-q10sx1dm	474	4	genes	gene	NNS
cord-015684-q10sx1dm	474	5	and	and	CC
cord-015684-q10sx1dm	474	6	their	-PRON-	PRP$
cord-015684-q10sx1dm	474	7	products	product	NNS
cord-015684-q10sx1dm	474	8	constitute	constitute	VBP
cord-015684-q10sx1dm	474	9	potential	potential	JJ
cord-015684-q10sx1dm	474	10	targets	target	NNS
cord-015684-q10sx1dm	474	11	for	for	IN
cord-015684-q10sx1dm	474	12	future	future	JJ
cord-015684-q10sx1dm	474	13	treatments	treatment	NNS
cord-015684-q10sx1dm	474	14	.	.	.
cord-015684-q10sx1dm	475	1	New	new	JJ
cord-015684-q10sx1dm	475	2	developments	development	NNS
cord-015684-q10sx1dm	475	3	in	in	IN
cord-015684-q10sx1dm	475	4	genomics	genomic	NNS
cord-015684-q10sx1dm	475	5	,	,	,
cord-015684-q10sx1dm	475	6	including	include	VBG
cord-015684-q10sx1dm	475	7	whole	whole	JJ
cord-015684-q10sx1dm	475	8	genome	genome	NN
cord-015684-q10sx1dm	475	9	genotyping	genotyping	NN
cord-015684-q10sx1dm	475	10	approaches	approach	NNS
cord-015684-q10sx1dm	475	11	and	and	CC
cord-015684-q10sx1dm	475	12	comprehensive	comprehensive	JJ
cord-015684-q10sx1dm	475	13	information	information	NN
cord-015684-q10sx1dm	475	14	on	on	IN
cord-015684-q10sx1dm	475	15	genomic	genomic	JJ
cord-015684-q10sx1dm	475	16	variation	variation	NN
cord-015684-q10sx1dm	475	17	across	across	IN
cord-015684-q10sx1dm	475	18	populations	population	NNS
cord-015684-q10sx1dm	475	19	,	,	,
cord-015684-q10sx1dm	475	20	coupled	couple	VBN
cord-015684-q10sx1dm	475	21	with	with	IN
cord-015684-q10sx1dm	475	22	large	large	JJ
cord-015684-q10sx1dm	475	23	-	-	HYPH
cord-015684-q10sx1dm	475	24	scale	scale	NN
cord-015684-q10sx1dm	475	25	clinical	clinical	JJ
cord-015684-q10sx1dm	475	26	trials	trial	NNS
cord-015684-q10sx1dm	475	27	in	in	IN
cord-015684-q10sx1dm	475	28	which	which	WDT
cord-015684-q10sx1dm	475	29	DNA	dna	NN
cord-015684-q10sx1dm	475	30	collection	collection	NN
cord-015684-q10sx1dm	475	31	is	be	VBZ
cord-015684-q10sx1dm	475	32	routine	routine	JJ
cord-015684-q10sx1dm	475	33	,	,	,
cord-015684-q10sx1dm	475	34	now	now	RB
cord-015684-q10sx1dm	475	35	provide	provide	VB
cord-015684-q10sx1dm	475	36	the	the	DT
cord-015684-q10sx1dm	475	37	impetus	impetus	NN
cord-015684-q10sx1dm	475	38	for	for	IN
cord-015684-q10sx1dm	475	39	a	a	DT
cord-015684-q10sx1dm	475	40	next	next	JJ
cord-015684-q10sx1dm	475	41	generation	generation	NN
cord-015684-q10sx1dm	475	42	of	of	IN
cord-015684-q10sx1dm	475	43	pharmacogenetic	pharmacogenetic	JJ
cord-015684-q10sx1dm	475	44	studies	study	NNS
cord-015684-q10sx1dm	475	45	and	and	CC
cord-015684-q10sx1dm	475	46	identifi	identifi	NNP
cord-015684-q10sx1dm	475	47	cation	cation	NNP
cord-015684-q10sx1dm	475	48	of	of	IN
cord-015684-q10sx1dm	475	49	novel	novel	JJ
cord-015684-q10sx1dm	475	50	candidate	candidate	NN
cord-015684-q10sx1dm	475	51	drugs	drug	NNS
cord-015684-q10sx1dm	475	52	.	.	.
cord-015684-q10sx1dm	476	1	[	[	-LRB-
cord-015684-q10sx1dm	476	2	139	139	CD
cord-015684-q10sx1dm	476	3	]	]	-RRB-
cord-015684-q10sx1dm	476	4	[	[	-LRB-
cord-015684-q10sx1dm	476	5	140	140	CD
cord-015684-q10sx1dm	476	6	]	]	-RRB-
cord-015684-q10sx1dm	477	1	[	[	-LRB-
cord-015684-q10sx1dm	477	2	141	141	CD
cord-015684-q10sx1dm	477	3	]	]	-RRB-
cord-015684-q10sx1dm	477	4	Cyclic	cyclic	JJ
cord-015684-q10sx1dm	477	5	nucleotide	nucleotide	JJ
cord-015684-q10sx1dm	477	6	phosphodiesterases	phosphodiesterase	NNS
cord-015684-q10sx1dm	477	7	(	(	-LRB-
cord-015684-q10sx1dm	477	8	PDEs	PDEs	NNP
cord-015684-q10sx1dm	477	9	)	)	-RRB-
cord-015684-q10sx1dm	477	10	are	be	VBP
cord-015684-q10sx1dm	477	11	a	a	DT
cord-015684-q10sx1dm	477	12	family	family	NN
cord-015684-q10sx1dm	477	13	of	of	IN
cord-015684-q10sx1dm	477	14	enzymes	enzyme	NNS
cord-015684-q10sx1dm	477	15	that	that	WDT
cord-015684-q10sx1dm	477	16	degrade	degrade	VBP
cord-015684-q10sx1dm	477	17	cAMP	camp	NN
cord-015684-q10sx1dm	477	18	and	and	CC
cord-015684-q10sx1dm	477	19	cGMP	cGMP	NNP
cord-015684-q10sx1dm	477	20	.	.	.
cord-015684-q10sx1dm	478	1	Intracellular	Intracellular	NNP
cord-015684-q10sx1dm	478	2	cyclic	cyclic	JJ
cord-015684-q10sx1dm	478	3	nucleotide	nucleotide	JJ
cord-015684-q10sx1dm	478	4	levels	level	NNS
cord-015684-q10sx1dm	478	5	increase	increase	VBP
cord-015684-q10sx1dm	478	6	in	in	IN
cord-015684-q10sx1dm	478	7	response	response	NN
cord-015684-q10sx1dm	478	8	to	to	IN
cord-015684-q10sx1dm	478	9	neurotransmitters	neurotransmitter	NNS
cord-015684-q10sx1dm	478	10	and	and	CC
cord-015684-q10sx1dm	478	11	are	be	VBP
cord-015684-q10sx1dm	478	12	down	down	RB
cord-015684-q10sx1dm	478	13	-	-	HYPH
cord-015684-q10sx1dm	478	14	regulated	regulate	VBN
cord-015684-q10sx1dm	478	15	through	through	IN
cord-015684-q10sx1dm	478	16	hydrolysis	hydrolysis	NN
cord-015684-q10sx1dm	478	17	catalyzed	catalyze	VBN
cord-015684-q10sx1dm	478	18	by	by	IN
cord-015684-q10sx1dm	478	19	PDEs	pde	NNS
cord-015684-q10sx1dm	478	20	,	,	,
cord-015684-q10sx1dm	478	21	which	which	WDT
cord-015684-q10sx1dm	478	22	are	be	VBP
cord-015684-q10sx1dm	478	23	therefore	therefore	RB
cord-015684-q10sx1dm	478	24	candidate	candidate	NN
cord-015684-q10sx1dm	478	25	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	478	26	targets	target	NNS
cord-015684-q10sx1dm	478	27	.	.	.
cord-015684-q10sx1dm	479	1	cAMP	cAMP	NNP
cord-015684-q10sx1dm	479	2	is	be	VBZ
cord-015684-q10sx1dm	479	3	a	a	DT
cord-015684-q10sx1dm	479	4	second	second	JJ
cord-015684-q10sx1dm	479	5	messenger	messenger	NN
cord-015684-q10sx1dm	479	6	involved	involve	VBN
cord-015684-q10sx1dm	479	7	in	in	IN
cord-015684-q10sx1dm	479	8	learning	learning	NN
cord-015684-q10sx1dm	479	9	,	,	,
cord-015684-q10sx1dm	479	10	memory	memory	NN
cord-015684-q10sx1dm	479	11	,	,	,
cord-015684-q10sx1dm	479	12	and	and	CC
cord-015684-q10sx1dm	479	13	mood	mood	NN
cord-015684-q10sx1dm	479	14	,	,	,
cord-015684-q10sx1dm	479	15	and	and	CC
cord-015684-q10sx1dm	479	16	cGMP	cGMP	NNP
cord-015684-q10sx1dm	479	17	modulates	modulate	VBZ
cord-015684-q10sx1dm	479	18	brain	brain	NN
cord-015684-q10sx1dm	479	19	processes	process	NNS
cord-015684-q10sx1dm	479	20	that	that	WDT
cord-015684-q10sx1dm	479	21	are	be	VBP
cord-015684-q10sx1dm	479	22	controlled	control	VBN
cord-015684-q10sx1dm	479	23	by	by	IN
cord-015684-q10sx1dm	479	24	the	the	DT
cord-015684-q10sx1dm	479	25	nitric	nitric	NN
cord-015684-q10sx1dm	479	26	oxide	oxide	NN
cord-015684-q10sx1dm	479	27	(	(	-LRB-
cord-015684-q10sx1dm	479	28	NO)/cGMP	NO)/cGMP	NNP
cord-015684-q10sx1dm	479	29	pathway	pathway	NN
cord-015684-q10sx1dm	479	30	.	.	.
cord-015684-q10sx1dm	480	1	The	the	DT
cord-015684-q10sx1dm	480	2	analysis	analysis	NN
cord-015684-q10sx1dm	480	3	of	of	IN
cord-015684-q10sx1dm	480	4	SNPs	SNPs	NNPS
cord-015684-q10sx1dm	480	5	in	in	IN
cord-015684-q10sx1dm	480	6	21	21	CD
cord-015684-q10sx1dm	480	7	genes	gene	NNS
cord-015684-q10sx1dm	480	8	of	of	IN
cord-015684-q10sx1dm	480	9	this	this	DT
cord-015684-q10sx1dm	480	10	superfamily	superfamily	NN
cord-015684-q10sx1dm	480	11	revealed	reveal	VBD
cord-015684-q10sx1dm	480	12	that	that	IN
cord-015684-q10sx1dm	480	13	polymorphisms	polymorphism	NNS
cord-015684-q10sx1dm	480	14	in	in	IN
cord-015684-q10sx1dm	480	15	PDE9A	PDE9A	NNS
cord-015684-q10sx1dm	481	1	and	and	CC
cord-015684-q10sx1dm	481	2	PDE11A	pde11a	NN
cord-015684-q10sx1dm	481	3	are	be	VBP
cord-015684-q10sx1dm	481	4	associated	associate	VBN
cord-015684-q10sx1dm	481	5	with	with	IN
cord-015684-q10sx1dm	481	6	major	major	JJ
cord-015684-q10sx1dm	481	7	depressive	depressive	JJ
cord-015684-q10sx1dm	481	8	disorder	disorder	NN
cord-015684-q10sx1dm	481	9	.	.	.
cord-015684-q10sx1dm	482	1	In	in	IN
cord-015684-q10sx1dm	482	2	addition	addition	NN
cord-015684-q10sx1dm	482	3	,	,	,
cord-015684-q10sx1dm	482	4	remission	remission	NN
cord-015684-q10sx1dm	482	5	on	on	IN
cord-015684-q10sx1dm	482	6	antidepressants	antidepressant	NNS
cord-015684-q10sx1dm	482	7	was	be	VBD
cord-015684-q10sx1dm	482	8	associated	associate	VBN
cord-015684-q10sx1dm	482	9	with	with	IN
cord-015684-q10sx1dm	482	10	polymorphisms	polymorphism	NNS
cord-015684-q10sx1dm	482	11	in	in	IN
cord-015684-q10sx1dm	482	12	PDE1A	PDE1A	NNS
cord-015684-q10sx1dm	482	13	and	and	CC
cord-015684-q10sx1dm	482	14	PDE11A.	pde11a.	NN
cord-015684-q10sx1dm	483	1	According	accord	VBG
cord-015684-q10sx1dm	483	2	to	to	IN
cord-015684-q10sx1dm	483	3	these	these	DT
cord-015684-q10sx1dm	483	4	results	result	NNS
cord-015684-q10sx1dm	483	5	,	,	,
cord-015684-q10sx1dm	483	6	it	-PRON-	PRP
cord-015684-q10sx1dm	483	7	has	have	VBZ
cord-015684-q10sx1dm	483	8	been	be	VBN
cord-015684-q10sx1dm	483	9	postulated	postulate	VBN
cord-015684-q10sx1dm	483	10	that	that	IN
cord-015684-q10sx1dm	483	11	PDE11A	pde11a	NN
cord-015684-q10sx1dm	483	12	(	(	-LRB-
cord-015684-q10sx1dm	483	13	haplotype	haplotype	NN
cord-015684-q10sx1dm	483	14	GAACC	GAACC	NNP
cord-015684-q10sx1dm	483	15	)	)	-RRB-
cord-015684-q10sx1dm	483	16	has	have	VBZ
cord-015684-q10sx1dm	483	17	a	a	DT
cord-015684-q10sx1dm	483	18	role	role	NN
cord-015684-q10sx1dm	483	19	in	in	IN
cord-015684-q10sx1dm	483	20	the	the	DT
cord-015684-q10sx1dm	483	21	pathogenesis	pathogenesis	NN
cord-015684-q10sx1dm	483	22	of	of	IN
cord-015684-q10sx1dm	483	23	major	major	JJ
cord-015684-q10sx1dm	483	24	depression	depression	NN
cord-015684-q10sx1dm	483	25	.	.	.
cord-015684-q10sx1dm	484	1	142	142	CD
cord-015684-q10sx1dm	485	1	Another	another	DT
cord-015684-q10sx1dm	485	2	example	example	NN
cord-015684-q10sx1dm	485	3	is	be	VBZ
cord-015684-q10sx1dm	485	4	the	the	DT
cord-015684-q10sx1dm	485	5	purinergic	purinergic	JJ
cord-015684-q10sx1dm	485	6	receptor	receptor	NN
cord-015684-q10sx1dm	485	7	gene	gene	NN
cord-015684-q10sx1dm	485	8	P2RX(7	P2RX(7	NNP
cord-015684-q10sx1dm	485	9	)	)	-RRB-
cord-015684-q10sx1dm	485	10	,	,	,
cord-015684-q10sx1dm	485	11	located	locate	VBN
cord-015684-q10sx1dm	485	12	in	in	IN
cord-015684-q10sx1dm	485	13	a	a	DT
cord-015684-q10sx1dm	485	14	major	major	JJ
cord-015684-q10sx1dm	485	15	linkage	linkage	NN
cord-015684-q10sx1dm	485	16	hotspot	hotspot	NN
cord-015684-q10sx1dm	485	17	for	for	IN
cord-015684-q10sx1dm	485	18	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	485	19	and	and	CC
cord-015684-q10sx1dm	485	20	bipolar	bipolar	JJ
cord-015684-q10sx1dm	485	21	disorder	disorder	NN
cord-015684-q10sx1dm	485	22	(	(	-LRB-
cord-015684-q10sx1dm	485	23	12q21	12q21	CD
cord-015684-q10sx1dm	485	24	-	-	SYM
cord-015684-q10sx1dm	485	25	33	33	CD
cord-015684-q10sx1dm	485	26	)	)	-RRB-
cord-015684-q10sx1dm	485	27	,	,	,
cord-015684-q10sx1dm	485	28	which	which	WDT
cord-015684-q10sx1dm	485	29	has	have	VBZ
cord-015684-q10sx1dm	485	30	been	be	VBN
cord-015684-q10sx1dm	485	31	associated	associate	VBN
cord-015684-q10sx1dm	485	32	with	with	IN
cord-015684-q10sx1dm	485	33	bipolar	bipolar	JJ
cord-015684-q10sx1dm	485	34	disorder	disorder	NN
cord-015684-q10sx1dm	485	35	,	,	,
cord-015684-q10sx1dm	485	36	but	but	CC
cord-015684-q10sx1dm	485	37	nine	nine	CD
cord-015684-q10sx1dm	485	38	functionally	functionally	RB
cord-015684-q10sx1dm	485	39	characterized	characterize	VBN
cord-015684-q10sx1dm	485	40	variants	variant	NNS
cord-015684-q10sx1dm	485	41	of	of	IN
cord-015684-q10sx1dm	485	42	P2RX(7	P2RX(7	NNP
cord-015684-q10sx1dm	485	43	)	)	-RRB-
cord-015684-q10sx1dm	485	44	did	do	VBD
cord-015684-q10sx1dm	485	45	not	not	RB
cord-015684-q10sx1dm	485	46	show	show	VB
cord-015684-q10sx1dm	485	47	association	association	NN
cord-015684-q10sx1dm	485	48	with	with	IN
cord-015684-q10sx1dm	485	49	schizophrenia	schizophrenia	NNP
cord-015684-q10sx1dm	485	50	.	.	.
cord-015684-q10sx1dm	486	1	143	143	CD
cord-015684-q10sx1dm	487	1	The	the	DT
cord-015684-q10sx1dm	487	2	possible	possible	JJ
cord-015684-q10sx1dm	487	3	role	role	NN
cord-015684-q10sx1dm	487	4	of	of	IN
cord-015684-q10sx1dm	487	5	a	a	DT
cord-015684-q10sx1dm	487	6	tag	tag	NN
cord-015684-q10sx1dm	487	7	SNP	SNP	NNP
cord-015684-q10sx1dm	487	8	(	(	-LRB-
cord-015684-q10sx1dm	487	9	the	the	DT
cord-015684-q10sx1dm	487	10	1359G	1359G	NNP
cord-015684-q10sx1dm	487	11	/	/	SYM
cord-015684-q10sx1dm	487	12	A	a	DT
cord-015684-q10sx1dm	487	13	polymorphism	polymorphism	NN
cord-015684-q10sx1dm	487	14	)	)	-RRB-
cord-015684-q10sx1dm	487	15	of	of	IN
cord-015684-q10sx1dm	487	16	the	the	DT
cord-015684-q10sx1dm	487	17	gene	gene	NN
cord-015684-q10sx1dm	487	18	encoding	encode	VBG
cord-015684-q10sx1dm	487	19	the	the	DT
cord-015684-q10sx1dm	487	20	cannabinoid	cannabinoid	NN
cord-015684-q10sx1dm	487	21	receptor	receptor	NN
cord-015684-q10sx1dm	487	22	type	type	NN
cord-015684-q10sx1dm	487	23	1	1	CD
cord-015684-q10sx1dm	487	24	(	(	-LRB-
cord-015684-q10sx1dm	487	25	CNR1	CNR1	NNP
cord-015684-q10sx1dm	487	26	)	)	-RRB-
cord-015684-q10sx1dm	487	27	has	have	VBZ
cord-015684-q10sx1dm	487	28	been	be	VBN
cord-015684-q10sx1dm	487	29	investigated	investigate	VBN
cord-015684-q10sx1dm	487	30	in	in	IN
cord-015684-q10sx1dm	487	31	schizophrenics	schizophrenic	NNS
cord-015684-q10sx1dm	487	32	treated	treat	VBN
cord-015684-q10sx1dm	487	33	with	with	IN
cord-015684-q10sx1dm	487	34	atypical	atypical	JJ
cord-015684-q10sx1dm	487	35	antipsychotics	antipsychotic	NNS
cord-015684-q10sx1dm	487	36	.	.	.
cord-015684-q10sx1dm	488	1	No	no	DT
cord-015684-q10sx1dm	488	2	difference	difference	NN
cord-015684-q10sx1dm	488	3	in	in	IN
cord-015684-q10sx1dm	488	4	1359G/	1359g/	CD
cord-015684-q10sx1dm	489	1	A	a	DT
cord-015684-q10sx1dm	489	2	polymorphism	polymorphism	NN
cord-015684-q10sx1dm	489	3	was	be	VBD
cord-015684-q10sx1dm	489	4	observed	observe	VBN
cord-015684-q10sx1dm	489	5	between	between	IN
cord-015684-q10sx1dm	489	6	patients	patient	NNS
cord-015684-q10sx1dm	489	7	and	and	CC
cord-015684-q10sx1dm	489	8	control	control	NN
cord-015684-q10sx1dm	489	9	subjects	subject	NNS
cord-015684-q10sx1dm	489	10	,	,	,
cord-015684-q10sx1dm	489	11	and	and	CC
cord-015684-q10sx1dm	489	12	no	no	DT
cord-015684-q10sx1dm	489	13	relation	relation	NN
cord-015684-q10sx1dm	489	14	-	-	HYPH
cord-015684-q10sx1dm	489	15	ships	ship	NNS
cord-015684-q10sx1dm	489	16	were	be	VBD
cord-015684-q10sx1dm	489	17	noted	note	VBN
cord-015684-q10sx1dm	489	18	between	between	IN
cord-015684-q10sx1dm	489	19	this	this	DT
cord-015684-q10sx1dm	489	20	polymorphism	polymorphism	NN
cord-015684-q10sx1dm	489	21	and	and	CC
cord-015684-q10sx1dm	489	22	any	any	DT
cord-015684-q10sx1dm	489	23	clinical	clinical	JJ
cord-015684-q10sx1dm	489	24	parameter	parameter	NN
cord-015684-q10sx1dm	489	25	considered	consider	VBN
cord-015684-q10sx1dm	489	26	as	as	IN
cord-015684-q10sx1dm	489	27	potential	potential	JJ
cord-015684-q10sx1dm	489	28	intermediate	intermediate	JJ
cord-015684-q10sx1dm	489	29	factor	factor	NN
cord-015684-q10sx1dm	489	30	;	;	:
cord-015684-q10sx1dm	489	31	however	however	RB
cord-015684-q10sx1dm	489	32	,	,	,
cord-015684-q10sx1dm	489	33	the	the	DT
cord-015684-q10sx1dm	489	34	G	g	NN
cord-015684-q10sx1dm	489	35	allele	allele	NN
cord-015684-q10sx1dm	489	36	was	be	VBD
cord-015684-q10sx1dm	489	37	signifi	signifi	NNP
cord-015684-q10sx1dm	489	38	cantly	cantly	RB
cord-015684-q10sx1dm	489	39	higher	high	JJR
cord-015684-q10sx1dm	489	40	among	among	IN
cord-015684-q10sx1dm	489	41	non	non	JJ
cord-015684-q10sx1dm	489	42	-	-	NNS
cord-015684-q10sx1dm	489	43	responders	responder	NNS
cord-015684-q10sx1dm	489	44	vs.	vs.	IN
cord-015684-q10sx1dm	489	45	responsive	responsive	JJ
cord-015684-q10sx1dm	489	46	patients	patient	NNS
cord-015684-q10sx1dm	489	47	,	,	,
cord-015684-q10sx1dm	489	48	suggesting	suggest	VBG
cord-015684-q10sx1dm	489	49	that	that	IN
cord-015684-q10sx1dm	489	50	the	the	DT
cord-015684-q10sx1dm	489	51	G	G	NNP
cord-015684-q10sx1dm	489	52	allele	allele	NN
cord-015684-q10sx1dm	489	53	of	of	IN
cord-015684-q10sx1dm	489	54	the	the	DT
cord-015684-q10sx1dm	489	55	CNR1	CNR1	NNP
cord-015684-q10sx1dm	489	56	gene	gene	NN
cord-015684-q10sx1dm	489	57	could	could	MD
cord-015684-q10sx1dm	489	58	be	be	VB
cord-015684-q10sx1dm	489	59	a	a	DT
cord-015684-q10sx1dm	489	60	pharmacogenetic	pharmacogenetic	JJ
cord-015684-q10sx1dm	489	61	rather	rather	RB
cord-015684-q10sx1dm	489	62	than	than	IN
cord-015684-q10sx1dm	489	63	a	a	DT
cord-015684-q10sx1dm	489	64	vulnerability	vulnerability	NN
cord-015684-q10sx1dm	489	65	factor	factor	NN
cord-015684-q10sx1dm	489	66	for	for	IN
cord-015684-q10sx1dm	489	67	schizophrenics	schizophrenic	NNS
cord-015684-q10sx1dm	489	68	.	.	.
cord-015684-q10sx1dm	490	1	144	144	CD
cord-015684-q10sx1dm	490	2	Synaptic	synaptic	JJ
cord-015684-q10sx1dm	490	3	dysfunction	dysfunction	NN
cord-015684-q10sx1dm	490	4	is	be	VBZ
cord-015684-q10sx1dm	490	5	a	a	DT
cord-015684-q10sx1dm	490	6	potential	potential	JJ
cord-015684-q10sx1dm	490	7	pathogenic	pathogenic	JJ
cord-015684-q10sx1dm	490	8	factor	factor	NN
cord-015684-q10sx1dm	490	9	in	in	IN
cord-015684-q10sx1dm	490	10	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	490	11	.	.	.
cord-015684-q10sx1dm	491	1	Cholesterol	cholesterol	NN
cord-015684-q10sx1dm	491	2	is	be	VBZ
cord-015684-q10sx1dm	491	3	an	an	DT
cord-015684-q10sx1dm	491	4	essential	essential	JJ
cord-015684-q10sx1dm	491	5	component	component	NN
cord-015684-q10sx1dm	491	6	of	of	IN
cord-015684-q10sx1dm	491	7	myelin	myelin	NN
cord-015684-q10sx1dm	491	8	and	and	CC
cord-015684-q10sx1dm	491	9	has	have	VBZ
cord-015684-q10sx1dm	491	10	proved	prove	VBN
cord-015684-q10sx1dm	491	11	important	important	JJ
cord-015684-q10sx1dm	491	12	for	for	IN
cord-015684-q10sx1dm	491	13	synapse	synapse	NN
cord-015684-q10sx1dm	491	14	formation	formation	NN
cord-015684-q10sx1dm	491	15	and	and	CC
cord-015684-q10sx1dm	491	16	lipid	lipid	NN
cord-015684-q10sx1dm	491	17	raft	raft	NN
cord-015684-q10sx1dm	491	18	function	function	NN
cord-015684-q10sx1dm	491	19	.	.	.
cord-015684-q10sx1dm	492	1	It	-PRON-	PRP
cord-015684-q10sx1dm	492	2	has	have	VBZ
cord-015684-q10sx1dm	492	3	been	be	VBN
cord-015684-q10sx1dm	492	4	demonstrated	demonstrate	VBN
cord-015684-q10sx1dm	492	5	that	that	IN
cord-015684-q10sx1dm	492	6	the	the	DT
cord-015684-q10sx1dm	492	7	antipsychotic	antipsychotic	JJ
cord-015684-q10sx1dm	492	8	drugs	drug	NNS
cord-015684-q10sx1dm	492	9	clozapine	clozapine	NNP
cord-015684-q10sx1dm	492	10	and	and	CC
cord-015684-q10sx1dm	492	11	haloperidol	haloperidol	NNP
cord-015684-q10sx1dm	492	12	stimulate	stimulate	VB
cord-015684-q10sx1dm	492	13	lipogenic	lipogenic	JJ
cord-015684-q10sx1dm	492	14	gene	gene	NN
cord-015684-q10sx1dm	492	15	expression	expression	NN
cord-015684-q10sx1dm	492	16	in	in	IN
cord-015684-q10sx1dm	492	17	glioma	glioma	NN
cord-015684-q10sx1dm	492	18	cells	cell	NNS
cord-015684-q10sx1dm	492	19	in	in	IN
cord-015684-q10sx1dm	492	20	culture	culture	NN
cord-015684-q10sx1dm	492	21	through	through	IN
cord-015684-q10sx1dm	492	22	activation	activation	NN
cord-015684-q10sx1dm	492	23	of	of	IN
cord-015684-q10sx1dm	492	24	the	the	DT
cord-015684-q10sx1dm	492	25	sterol	sterol	NN
cord-015684-q10sx1dm	492	26	regulatory	regulatory	JJ
cord-015684-q10sx1dm	492	27	element	element	NN
cord-015684-q10sx1dm	492	28	-	-	HYPH
cord-015684-q10sx1dm	492	29	binding	bind	VBG
cord-015684-q10sx1dm	492	30	protein	protein	NN
cord-015684-q10sx1dm	492	31	(	(	-LRB-
cord-015684-q10sx1dm	492	32	SREBP	SREBP	NNP
cord-015684-q10sx1dm	492	33	)	)	-RRB-
cord-015684-q10sx1dm	492	34	transcription	transcription	NN
cord-015684-q10sx1dm	492	35	factors	factor	NNS
cord-015684-q10sx1dm	492	36	.	.	.
cord-015684-q10sx1dm	493	1	Recently	recently	RB
cord-015684-q10sx1dm	493	2	,	,	,
cord-015684-q10sx1dm	493	3	the	the	DT
cord-015684-q10sx1dm	493	4	action	action	NN
cord-015684-q10sx1dm	493	5	of	of	IN
cord-015684-q10sx1dm	493	6	chlorpromazine	chlorpromazine	NN
cord-015684-q10sx1dm	493	7	,	,	,
cord-015684-q10sx1dm	493	8	haloperidol	haloperidol	NNP
cord-015684-q10sx1dm	493	9	,	,	,
cord-015684-q10sx1dm	493	10	clozapine	clozapine	NN
cord-015684-q10sx1dm	493	11	,	,	,
cord-015684-q10sx1dm	493	12	olanzapine	olanzapine	NN
cord-015684-q10sx1dm	493	13	,	,	,
cord-015684-q10sx1dm	493	14	risperidone	risperidone	NNP
cord-015684-q10sx1dm	493	15	and	and	CC
cord-015684-q10sx1dm	493	16	ziprasidone	ziprasidone	NN
cord-015684-q10sx1dm	493	17	on	on	IN
cord-015684-q10sx1dm	493	18	SREBP	SREBP	NNP
cord-015684-q10sx1dm	493	19	and	and	CC
cord-015684-q10sx1dm	493	20	SREBP	SREBP	NNP
cord-015684-q10sx1dm	493	21	-	-	HYPH
cord-015684-q10sx1dm	493	22	controlled	control	VBN
cord-015684-q10sx1dm	493	23	gene	gene	NN
cord-015684-q10sx1dm	493	24	expression	expression	NN
cord-015684-q10sx1dm	493	25	(	(	-LRB-
cord-015684-q10sx1dm	493	26	acetyl	acetyl	NN
cord-015684-q10sx1dm	493	27	-	-	HYPH
cord-015684-q10sx1dm	493	28	CoA	coa	NN
cord-015684-q10sx1dm	493	29	acetyltransferase	acetyltransferase	NNP
cord-015684-q10sx1dm	493	30	2	2	CD
cord-015684-q10sx1dm	493	31	,	,	,
cord-015684-q10sx1dm	493	32	acetoacetyl	acetoacetyl	NNP
cord-015684-q10sx1dm	493	33	-	-	HYPH
cord-015684-q10sx1dm	493	34	CoA	CoA	NNP
cord-015684-q10sx1dm	493	35	thiolase	thiolase	NN
cord-015684-q10sx1dm	493	36	,	,	,
cord-015684-q10sx1dm	493	37	ACAT2	ACAT2	NNS
cord-015684-q10sx1dm	493	38	;	;	:
cord-015684-q10sx1dm	493	39	3-hydroxy-3-methylglutaryl	3-hydroxy-3-methylglutaryl	CD
cord-015684-q10sx1dm	493	40	-	-	HYPH
cord-015684-q10sx1dm	493	41	CoA	coa	NN
cord-015684-q10sx1dm	493	42	reductase	reductase	NN
cord-015684-q10sx1dm	493	43	,	,	,
cord-015684-q10sx1dm	493	44	HMGCR	HMGCR	NNP
cord-015684-q10sx1dm	493	45	;	;	:
cord-015684-q10sx1dm	493	46	3-hydroxy-3-methylglutaryl	3-hydroxy-3-methylglutaryl	CD
cord-015684-q10sx1dm	493	47	-	-	HYPH
cord-015684-q10sx1dm	493	48	CoA	coa	NN
cord-015684-q10sx1dm	493	49	synthase	synthase	NN
cord-015684-q10sx1dm	493	50	1	1	CD
cord-015684-q10sx1dm	493	51	,	,	,
cord-015684-q10sx1dm	493	52	HMGCS1	hmgcs1	NN
cord-015684-q10sx1dm	493	53	;	;	:
cord-015684-q10sx1dm	493	54	FDPS	FDPS	NNP
cord-015684-q10sx1dm	493	55	;	;	:
cord-015684-q10sx1dm	493	56	sterol	sterol	NN
cord-015684-q10sx1dm	493	57	-	-	HYPH
cord-015684-q10sx1dm	493	58	C5-desaturase	c5-desaturase	NN
cord-015684-q10sx1dm	493	59	like	like	UH
cord-015684-q10sx1dm	493	60	,	,	,
cord-015684-q10sx1dm	493	61	SC5DL	SC5DL	NNP
cord-015684-q10sx1dm	493	62	;	;	:
cord-015684-q10sx1dm	493	63	7-dehydrocholesterol	7-dehydrocholesterol	CD
cord-015684-q10sx1dm	493	64	reductase	reductase	NN
cord-015684-q10sx1dm	493	65	,	,	,
cord-015684-q10sx1dm	493	66	DHCR7	dhcr7	XX
cord-015684-q10sx1dm	493	67	;	;	:
cord-015684-q10sx1dm	493	68	low	low	JJ
cord-015684-q10sx1dm	493	69	density	density	NN
cord-015684-q10sx1dm	493	70	lipoprotein	lipoprotein	NN
cord-015684-q10sx1dm	493	71	receptor	receptor	NN
cord-015684-q10sx1dm	493	72	,	,	,
cord-015684-q10sx1dm	493	73	LDLR	LDLR	NNP
cord-015684-q10sx1dm	493	74	;	;	:
cord-015684-q10sx1dm	493	75	fatty	fatty	JJ
cord-015684-q10sx1dm	493	76	acid	acid	NN
cord-015684-q10sx1dm	493	77	synthase	synthase	NN
cord-015684-q10sx1dm	493	78	;	;	:
cord-015684-q10sx1dm	493	79	farsenyl	farsenyl	JJ
cord-015684-q10sx1dm	493	80	diphosphate	diphosphate	NN
cord-015684-q10sx1dm	493	81	synthase	synthase	NN
cord-015684-q10sx1dm	493	82	,	,	,
cord-015684-q10sx1dm	493	83	FASN	FASN	NNP
cord-015684-q10sx1dm	493	84	;	;	:
cord-015684-q10sx1dm	493	85	stearoyl	stearoyl	NNP
cord-015684-q10sx1dm	493	86	-	-	HYPH
cord-015684-q10sx1dm	493	87	CoA	coa	NN
cord-015684-q10sx1dm	493	88	desaturase	desaturase	NN
cord-015684-q10sx1dm	493	89	,	,	,
cord-015684-q10sx1dm	493	90	delta-9-desaturase	delta-9-desaturase	NNP
cord-015684-q10sx1dm	493	91	,	,	,
cord-015684-q10sx1dm	493	92	SCD1	SCD1	NNP
cord-015684-q10sx1dm	493	93	)	)	-RRB-
cord-015684-q10sx1dm	493	94	has	have	VBZ
cord-015684-q10sx1dm	493	95	been	be	VBN
cord-015684-q10sx1dm	493	96	investigated	investigate	VBN
cord-015684-q10sx1dm	493	97	in	in	IN
cord-015684-q10sx1dm	493	98	different	different	JJ
cord-015684-q10sx1dm	493	99	CNS	CNS	NNP
cord-015684-q10sx1dm	493	100	human	human	JJ
cord-015684-q10sx1dm	493	101	cell	cell	NN
cord-015684-q10sx1dm	493	102	lines	line	NNS
cord-015684-q10sx1dm	493	103	,	,	,
cord-015684-q10sx1dm	493	104	demonstrating	demonstrate	VBG
cord-015684-q10sx1dm	493	105	that	that	IN
cord-015684-q10sx1dm	493	106	antipsychotic	antipsychotic	NN
cord-015684-q10sx1dm	493	107	-	-	HYPH
cord-015684-q10sx1dm	493	108	induced	induce	VBN
cord-015684-q10sx1dm	493	109	activation	activation	NN
cord-015684-q10sx1dm	493	110	of	of	IN
cord-015684-q10sx1dm	493	111	lipogenesis	lipogenesis	NN
cord-015684-q10sx1dm	493	112	is	be	VBZ
cord-015684-q10sx1dm	493	113	most	most	RBS
cord-015684-q10sx1dm	493	114	prominent	prominent	JJ
cord-015684-q10sx1dm	493	115	in	in	IN
cord-015684-q10sx1dm	493	116	glial	glial	JJ
cord-015684-q10sx1dm	493	117	cells	cell	NNS
cord-015684-q10sx1dm	493	118	and	and	CC
cord-015684-q10sx1dm	493	119	that	that	IN
cord-015684-q10sx1dm	493	120	this	this	DT
cord-015684-q10sx1dm	493	121	mechanism	mechanism	NN
cord-015684-q10sx1dm	493	122	could	could	MD
cord-015684-q10sx1dm	493	123	be	be	VB
cord-015684-q10sx1dm	493	124	relevant	relevant	JJ
cord-015684-q10sx1dm	493	125	for	for	IN
cord-015684-q10sx1dm	493	126	the	the	DT
cord-015684-q10sx1dm	493	127	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	493	128	efficacy	efficacy	NN
cord-015684-q10sx1dm	493	129	of	of	IN
cord-015684-q10sx1dm	493	130	some	some	DT
cord-015684-q10sx1dm	493	131	antipsychotic	antipsychotic	JJ
cord-015684-q10sx1dm	493	132	drugs	drug	NNS
cord-015684-q10sx1dm	493	133	.	.	.
cord-015684-q10sx1dm	494	1	145	145	CD
cord-015684-q10sx1dm	494	2	RGS2	RGS2	NNP
cord-015684-q10sx1dm	494	3	(	(	-LRB-
cord-015684-q10sx1dm	494	4	regulator	regulator	NN
cord-015684-q10sx1dm	494	5	of	of	IN
cord-015684-q10sx1dm	494	6	G	g	NN
cord-015684-q10sx1dm	494	7	-	-	HYPH
cord-015684-q10sx1dm	494	8	protein	protein	NN
cord-015684-q10sx1dm	494	9	signaling	signal	VBG
cord-015684-q10sx1dm	494	10	2	2	CD
cord-015684-q10sx1dm	494	11	)	)	-RRB-
cord-015684-q10sx1dm	494	12	modulates	modulate	VBZ
cord-015684-q10sx1dm	494	13	dopamine	dopamine	NN
cord-015684-q10sx1dm	494	14	receptor	receptor	NN
cord-015684-q10sx1dm	494	15	signal	signal	NN
cord-015684-q10sx1dm	494	16	transduction	transduction	NN
cord-015684-q10sx1dm	494	17	.	.	.
cord-015684-q10sx1dm	495	1	Functional	functional	JJ
cord-015684-q10sx1dm	495	2	variants	variant	NNS
cord-015684-q10sx1dm	495	3	of	of	IN
cord-015684-q10sx1dm	495	4	this	this	DT
cord-015684-q10sx1dm	495	5	gene	gene	NN
cord-015684-q10sx1dm	495	6	(	(	-LRB-
cord-015684-q10sx1dm	495	7	RGS2-rs	RGS2-rs	NNP
cord-015684-q10sx1dm	495	8	4606	4606	CD
cord-015684-q10sx1dm	495	9	C	C	NNP
cord-015684-q10sx1dm	495	10	/	/	SYM
cord-015684-q10sx1dm	495	11	G	G	NNP
cord-015684-q10sx1dm	495	12	)	)	-RRB-
cord-015684-q10sx1dm	495	13	may	may	MD
cord-015684-q10sx1dm	495	14	infl	infl	VB
cord-015684-q10sx1dm	495	15	uence	uence	NN
cord-015684-q10sx1dm	495	16	susceptibility	susceptibility	NN
cord-015684-q10sx1dm	495	17	to	to	IN
cord-015684-q10sx1dm	495	18	extrapyramidal	extrapyramidal	JJ
cord-015684-q10sx1dm	495	19	symptoms	symptom	NNS
cord-015684-q10sx1dm	495	20	induced	induce	VBN
cord-015684-q10sx1dm	495	21	by	by	IN
cord-015684-q10sx1dm	495	22	antipsychotic	antipsychotic	JJ
cord-015684-q10sx1dm	495	23	drugs	drug	NNS
cord-015684-q10sx1dm	495	24	.	.	.
cord-015684-q10sx1dm	496	1	This	this	DT
cord-015684-q10sx1dm	496	2	SNP	SNP	NNP
cord-015684-q10sx1dm	496	3	is	be	VBZ
cord-015684-q10sx1dm	496	4	located	locate	VBN
cord-015684-q10sx1dm	496	5	in	in	IN
cord-015684-q10sx1dm	496	6	the	the	DT
cord-015684-q10sx1dm	496	7	3′-regulatory	3′-regulatory	CD
cord-015684-q10sx1dm	496	8	region	region	NN
cord-015684-q10sx1dm	496	9	of	of	IN
cord-015684-q10sx1dm	496	10	the	the	DT
cord-015684-q10sx1dm	496	11	gene	gene	NN
cord-015684-q10sx1dm	496	12	,	,	,
cord-015684-q10sx1dm	496	13	and	and	CC
cord-015684-q10sx1dm	496	14	is	be	VBZ
cord-015684-q10sx1dm	496	15	known	know	VBN
cord-015684-q10sx1dm	496	16	to	to	IN
cord-015684-q10sx1dm	496	17	infl	infl	NN
cord-015684-q10sx1dm	496	18	uence	uence	NN
cord-015684-q10sx1dm	497	1	RGS2	RGS2	NNP
cord-015684-q10sx1dm	497	2	mRNA	mrna	NN
cord-015684-q10sx1dm	497	3	levels	level	NNS
cord-015684-q10sx1dm	497	4	and	and	CC
cord-015684-q10sx1dm	497	5	protein	protein	NN
cord-015684-q10sx1dm	497	6	expression	expression	NN
cord-015684-q10sx1dm	497	7	.	.	.
cord-015684-q10sx1dm	498	1	146	146	CD
cord-015684-q10sx1dm	499	1	Furthermore	furthermore	RB
cord-015684-q10sx1dm	499	2	,	,	,
cord-015684-q10sx1dm	499	3	RGS4	rgs4	JJ
cord-015684-q10sx1dm	499	4	(	(	-LRB-
cord-015684-q10sx1dm	499	5	regulator	regulator	NN
cord-015684-q10sx1dm	499	6	of	of	IN
cord-015684-q10sx1dm	499	7	G	g	NN
cord-015684-q10sx1dm	499	8	protein	protein	NN
cord-015684-q10sx1dm	499	9	signaling	signal	VBG
cord-015684-q10sx1dm	499	10	4	4	CD
cord-015684-q10sx1dm	499	11	)	)	-RRB-
cord-015684-q10sx1dm	499	12	genotypes	genotype	NNS
cord-015684-q10sx1dm	499	13	predict	predict	VBP
cord-015684-q10sx1dm	499	14	both	both	CC
cord-015684-q10sx1dm	499	15	the	the	DT
cord-015684-q10sx1dm	499	16	severity	severity	NN
cord-015684-q10sx1dm	499	17	at	at	IN
cord-015684-q10sx1dm	499	18	baseline	baseline	JJ
cord-015684-q10sx1dm	499	19	symptoms	symptom	NNS
cord-015684-q10sx1dm	499	20	and	and	CC
cord-015684-q10sx1dm	499	21	relative	relative	JJ
cord-015684-q10sx1dm	499	22	responsiveness	responsiveness	NN
cord-015684-q10sx1dm	499	23	to	to	IN
cord-015684-q10sx1dm	499	24	antipsychotic	antipsychotic	JJ
cord-015684-q10sx1dm	499	25	medication	medication	NN
cord-015684-q10sx1dm	499	26	.	.	.
cord-015684-q10sx1dm	500	1	147	147	CD
cord-015684-q10sx1dm	500	2	Tardive	Tardive	NNP
cord-015684-q10sx1dm	500	3	dyskinesia	dyskinesia	NN
cord-015684-q10sx1dm	500	4	is	be	VBZ
cord-015684-q10sx1dm	500	5	characterized	characterize	VBN
cord-015684-q10sx1dm	500	6	by	by	IN
cord-015684-q10sx1dm	500	7	involuntary	involuntary	JJ
cord-015684-q10sx1dm	500	8	movements	movement	NNS
cord-015684-q10sx1dm	500	9	predominantly	predominantly	RB
cord-015684-q10sx1dm	500	10	in	in	IN
cord-015684-q10sx1dm	500	11	the	the	DT
cord-015684-q10sx1dm	500	12	orofacial	orofacial	JJ
cord-015684-q10sx1dm	500	13	region	region	NN
cord-015684-q10sx1dm	500	14	and	and	CC
cord-015684-q10sx1dm	500	15	develops	develop	VBZ
cord-015684-q10sx1dm	500	16	in	in	IN
cord-015684-q10sx1dm	500	17	approximately	approximately	RB
cord-015684-q10sx1dm	500	18	20	20	CD
cord-015684-q10sx1dm	500	19	%	%	NN
cord-015684-q10sx1dm	500	20	of	of	IN
cord-015684-q10sx1dm	500	21	patients	patient	NNS
cord-015684-q10sx1dm	500	22	during	during	IN
cord-015684-q10sx1dm	500	23	long	long	JJ
cord-015684-q10sx1dm	500	24	-	-	HYPH
cord-015684-q10sx1dm	500	25	term	term	NN
cord-015684-q10sx1dm	500	26	treatment	treatment	NN
cord-015684-q10sx1dm	500	27	with	with	IN
cord-015684-q10sx1dm	500	28	typical	typical	JJ
cord-015684-q10sx1dm	500	29	antipsychotics	antipsychotic	NNS
cord-015684-q10sx1dm	500	30	.	.	.
cord-015684-q10sx1dm	501	1	Polymorphic	polymorphic	JJ
cord-015684-q10sx1dm	501	2	variants	variant	NNS
cord-015684-q10sx1dm	501	3	of	of	IN
cord-015684-q10sx1dm	501	4	CYP1A2	CYP1A2	NNP
cord-015684-q10sx1dm	501	5	,	,	,
cord-015684-q10sx1dm	501	6	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	501	7	,	,	,
cord-015684-q10sx1dm	501	8	and	and	CC
cord-015684-q10sx1dm	501	9	DRD3	DRD3	NNP
cord-015684-q10sx1dm	501	10	genes	gene	NNS
cord-015684-q10sx1dm	501	11	have	have	VBP
cord-015684-q10sx1dm	501	12	been	be	VBN
cord-015684-q10sx1dm	501	13	associated	associate	VBN
cord-015684-q10sx1dm	501	14	with	with	IN
cord-015684-q10sx1dm	501	15	tardive	tardive	JJ
cord-015684-q10sx1dm	501	16	dyskinesia	dyskinesia	NN
cord-015684-q10sx1dm	501	17	in	in	IN
cord-015684-q10sx1dm	501	18	schizophrenics	schizophrenic	NNS
cord-015684-q10sx1dm	501	19	.	.	.
cord-015684-q10sx1dm	502	1	148	148	CD
cord-015684-q10sx1dm	502	2	,	,	,
cord-015684-q10sx1dm	502	3	149	149	CD
cord-015684-q10sx1dm	503	1	In	in	IN
cord-015684-q10sx1dm	503	2	contrast	contrast	NN
cord-015684-q10sx1dm	503	3	,	,	,
cord-015684-q10sx1dm	503	4	the	the	DT
cord-015684-q10sx1dm	503	5	haplotype	haplotype	NN
cord-015684-q10sx1dm	503	6	T-4b	T-4b	NNP
cord-015684-q10sx1dm	503	7	-	-	HYPH
cord-015684-q10sx1dm	503	8	Glu	Glu	NNP
cord-015684-q10sx1dm	503	9	of	of	IN
cord-015684-q10sx1dm	503	10	the	the	DT
cord-015684-q10sx1dm	503	11	endothelial	endothelial	JJ
cord-015684-q10sx1dm	503	12	nitric	nitric	JJ
cord-015684-q10sx1dm	503	13	oxide	oxide	NN
cord-015684-q10sx1dm	503	14	synthase	synthase	NN
cord-015684-q10sx1dm	503	15	(	(	-LRB-
cord-015684-q10sx1dm	503	16	NOS3	NOS3	NNP
cord-015684-q10sx1dm	503	17	)	)	-RRB-
cord-015684-q10sx1dm	503	18	gene	gene	NN
cord-015684-q10sx1dm	503	19	(	(	-LRB-
cord-015684-q10sx1dm	503	20	-786	-786	NN
cord-015684-q10sx1dm	503	21	T	t	NN
cord-015684-q10sx1dm	503	22	>	>	XX
cord-015684-q10sx1dm	503	23	C	c	NN
cord-015684-q10sx1dm	503	24	in	in	IN
cord-015684-q10sx1dm	503	25	the	the	DT
cord-015684-q10sx1dm	503	26	promoter	promoter	NN
cord-015684-q10sx1dm	503	27	region	region	NN
cord-015684-q10sx1dm	503	28	,	,	,
cord-015684-q10sx1dm	503	29	27-bp	27-bp	CD
cord-015684-q10sx1dm	503	30	variable	variable	JJ
cord-015684-q10sx1dm	503	31	number	number	NN
cord-015684-q10sx1dm	503	32	of	of	IN
cord-015684-q10sx1dm	503	33	tandem	tandem	NN
cord-015684-q10sx1dm	503	34	repeats	repeat	NNS
cord-015684-q10sx1dm	503	35	in	in	IN
cord-015684-q10sx1dm	503	36	intron	intron	NN
cord-015684-q10sx1dm	503	37	4	4	CD
cord-015684-q10sx1dm	503	38	,	,	,
cord-015684-q10sx1dm	503	39	Glu298Asp	Glu298Asp	NNP
cord-015684-q10sx1dm	503	40	in	in	IN
cord-015684-q10sx1dm	503	41	exon	exon	NN
cord-015684-q10sx1dm	503	42	7	7	CD
cord-015684-q10sx1dm	503	43	)	)	-RRB-
cord-015684-q10sx1dm	504	1	might	may	MD
cord-015684-q10sx1dm	504	2	represent	represent	VB
cord-015684-q10sx1dm	504	3	a	a	DT
cord-015684-q10sx1dm	504	4	protective	protective	JJ
cord-015684-q10sx1dm	504	5	haplotype	haplotype	NN
cord-015684-q10sx1dm	504	6	against	against	IN
cord-015684-q10sx1dm	504	7	tardive	tardive	NNP
cord-015684-q10sx1dm	504	8	dyskinesia	dyskinesia	NN
cord-015684-q10sx1dm	504	9	after	after	IN
cord-015684-q10sx1dm	504	10	long	long	JJ
cord-015684-q10sx1dm	504	11	-	-	HYPH
cord-015684-q10sx1dm	504	12	term	term	NN
cord-015684-q10sx1dm	504	13	antipsychotic	antipsychotic	JJ
cord-015684-q10sx1dm	504	14	treatment	treatment	NN
cord-015684-q10sx1dm	504	15	.	.	.
cord-015684-q10sx1dm	505	1	150	150	CD
cord-015684-q10sx1dm	506	1	The	the	DT
cord-015684-q10sx1dm	506	2	T102C	t102c	JJ
cord-015684-q10sx1dm	506	3	variant	variant	NN
cord-015684-q10sx1dm	506	4	in	in	IN
cord-015684-q10sx1dm	506	5	the	the	DT
cord-015684-q10sx1dm	506	6	serotonin	serotonin	NN
cord-015684-q10sx1dm	506	7	2A	2a	CD
cord-015684-q10sx1dm	506	8	receptor	receptor	NN
cord-015684-q10sx1dm	506	9	(	(	-LRB-
cord-015684-q10sx1dm	506	10	HTR2A	htr2a	CD
cord-015684-q10sx1dm	506	11	)	)	-RRB-
cord-015684-q10sx1dm	506	12	and	and	CC
cord-015684-q10sx1dm	506	13	the	the	DT
cord-015684-q10sx1dm	506	14	Ser9Gly	Ser9Gly	NNP
cord-015684-q10sx1dm	506	15	variant	variant	NN
cord-015684-q10sx1dm	506	16	in	in	IN
cord-015684-q10sx1dm	506	17	the	the	DT
cord-015684-q10sx1dm	506	18	dopamine	dopamine	NN
cord-015684-q10sx1dm	506	19	D3	D3	NNP
cord-015684-q10sx1dm	506	20	receptor	receptor	NN
cord-015684-q10sx1dm	506	21	(	(	-LRB-
cord-015684-q10sx1dm	506	22	DRD3	DRD3	NNP
cord-015684-q10sx1dm	506	23	)	)	-RRB-
cord-015684-q10sx1dm	506	24	were	be	VBD
cord-015684-q10sx1dm	506	25	associated	associate	VBN
cord-015684-q10sx1dm	506	26	with	with	IN
cord-015684-q10sx1dm	506	27	a	a	DT
cord-015684-q10sx1dm	506	28	risperidone	risperidone	JJ
cord-015684-q10sx1dm	506	29	response	response	NN
cord-015684-q10sx1dm	506	30	to	to	IN
cord-015684-q10sx1dm	506	31	exacerbated	exacerbate	VBN
cord-015684-q10sx1dm	506	32	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	506	33	.	.	.
cord-015684-q10sx1dm	507	1	The	the	DT
cord-015684-q10sx1dm	507	2	patients	patient	NNS
cord-015684-q10sx1dm	507	3	with	with	IN
cord-015684-q10sx1dm	507	4	T	T	NNP
cord-015684-q10sx1dm	507	5	/	/	SYM
cord-015684-q10sx1dm	507	6	T	t	NN
cord-015684-q10sx1dm	507	7	in	in	IN
cord-015684-q10sx1dm	507	8	the	the	DT
cord-015684-q10sx1dm	507	9	HTR2A	HTR2A	NNP
cord-015684-q10sx1dm	507	10	gene	gene	NN
cord-015684-q10sx1dm	507	11	show	show	NN
cord-015684-q10sx1dm	507	12	less	less	RBR
cord-015684-q10sx1dm	507	13	clinical	clinical	JJ
cord-015684-q10sx1dm	507	14	improvement	improvement	NN
cord-015684-q10sx1dm	507	15	than	than	IN
cord-015684-q10sx1dm	507	16	do	do	VB
cord-015684-q10sx1dm	507	17	those	those	DT
cord-015684-q10sx1dm	507	18	with	with	IN
cord-015684-q10sx1dm	507	19	T	T	NNP
cord-015684-q10sx1dm	507	20	/	/	SYM
cord-015684-q10sx1dm	507	21	C	C	NNP
cord-015684-q10sx1dm	507	22	or	or	CC
cord-015684-q10sx1dm	507	23	C	C	NNP
cord-015684-q10sx1dm	507	24	/	/	SYM
cord-015684-q10sx1dm	507	25	C.	c.	NN
cord-015684-q10sx1dm	508	1	The	the	DT
cord-015684-q10sx1dm	508	2	C	C	NNP
cord-015684-q10sx1dm	508	3	allele	allele	NN
cord-015684-q10sx1dm	508	4	is	be	VBZ
cord-015684-q10sx1dm	508	5	more	more	RBR
cord-015684-q10sx1dm	508	6	frequent	frequent	JJ
cord-015684-q10sx1dm	508	7	in	in	IN
cord-015684-q10sx1dm	508	8	responders	responder	NNS
cord-015684-q10sx1dm	508	9	.	.	.
cord-015684-q10sx1dm	509	1	When	when	WRB
cord-015684-q10sx1dm	509	2	combinations	combination	NNS
cord-015684-q10sx1dm	509	3	of	of	IN
cord-015684-q10sx1dm	509	4	both	both	DT
cord-015684-q10sx1dm	509	5	polymorphisms	polymorphism	NNS
cord-015684-q10sx1dm	509	6	are	be	VBP
cord-015684-q10sx1dm	509	7	considered	consider	VBN
cord-015684-q10sx1dm	509	8	,	,	,
cord-015684-q10sx1dm	509	9	patients	patient	NNS
cord-015684-q10sx1dm	509	10	who	who	WP
cord-015684-q10sx1dm	509	11	have	have	VBP
cord-015684-q10sx1dm	509	12	T	T	NNP
cord-015684-q10sx1dm	509	13	/	/	SYM
cord-015684-q10sx1dm	509	14	T	t	NN
cord-015684-q10sx1dm	509	15	in	in	IN
cord-015684-q10sx1dm	509	16	the	the	DT
cord-015684-q10sx1dm	509	17	HTR2A	htr2a	CD
cord-015684-q10sx1dm	509	18	gene	gene	NN
cord-015684-q10sx1dm	509	19	and	and	CC
cord-015684-q10sx1dm	509	20	encode	encode	VB
cord-015684-q10sx1dm	509	21	Ser	Ser	NNP
cord-015684-q10sx1dm	509	22	/	/	SYM
cord-015684-q10sx1dm	509	23	Ser	Ser	NNP
cord-015684-q10sx1dm	509	24	or	or	CC
cord-015684-q10sx1dm	509	25	Ser	Ser	NNP
cord-015684-q10sx1dm	509	26	/	/	SYM
cord-015684-q10sx1dm	509	27	Gly	Gly	NNP
cord-015684-q10sx1dm	509	28	from	from	IN
cord-015684-q10sx1dm	509	29	DRD3	DRD3	NNP
cord-015684-q10sx1dm	509	30	gene	gene	NN
cord-015684-q10sx1dm	509	31	have	have	VBP
cord-015684-q10sx1dm	509	32	a	a	DT
cord-015684-q10sx1dm	509	33	higher	high	JJR
cord-015684-q10sx1dm	509	34	propensity	propensity	NN
cord-015684-q10sx1dm	509	35	to	to	IN
cord-015684-q10sx1dm	509	36	non	non	JJ
cord-015684-q10sx1dm	509	37	-	-	JJ
cord-015684-q10sx1dm	509	38	responsiveness	responsiveness	NN
cord-015684-q10sx1dm	509	39	compared	compare	VBN
cord-015684-q10sx1dm	509	40	to	to	IN
cord-015684-q10sx1dm	509	41	other	other	JJ
cord-015684-q10sx1dm	509	42	subjects	subject	NNS
cord-015684-q10sx1dm	509	43	,	,	,
cord-015684-q10sx1dm	509	44	suggesting	suggest	VBG
cord-015684-q10sx1dm	509	45	that	that	IN
cord-015684-q10sx1dm	509	46	the	the	DT
cord-015684-q10sx1dm	509	47	HTR2A	htr2a	CD
cord-015684-q10sx1dm	509	48	T102C	t102c	JJ
cord-015684-q10sx1dm	509	49	variant	variant	NN
cord-015684-q10sx1dm	509	50	could	could	MD
cord-015684-q10sx1dm	509	51	be	be	VB
cord-015684-q10sx1dm	509	52	a	a	DT
cord-015684-q10sx1dm	509	53	potential	potential	JJ
cord-015684-q10sx1dm	509	54	indicator	indicator	NN
cord-015684-q10sx1dm	509	55	of	of	IN
cord-015684-q10sx1dm	509	56	clinical	clinical	JJ
cord-015684-q10sx1dm	509	57	improvement	improvement	NN
cord-015684-q10sx1dm	509	58	after	after	IN
cord-015684-q10sx1dm	509	59	risperidone	risperidone	NNP
cord-015684-q10sx1dm	509	60	treatment	treatment	NN
cord-015684-q10sx1dm	509	61	.	.	.
cord-015684-q10sx1dm	510	1	151	151	CD
cord-015684-q10sx1dm	511	1	There	there	EX
cord-015684-q10sx1dm	511	2	is	be	VBZ
cord-015684-q10sx1dm	511	3	a	a	DT
cord-015684-q10sx1dm	511	4	signifi	signifi	NN
cord-015684-q10sx1dm	511	5	ca	can	MD
cord-015684-q10sx1dm	511	6	nt	not	RB
cord-015684-q10sx1dm	511	7	relationship	relationship	NN
cord-015684-q10sx1dm	511	8	between	between	IN
cord-015684-q10sx1dm	511	9	a	a	DT
cord-015684-q10sx1dm	511	10	promoter	promoter	NN
cord-015684-q10sx1dm	511	11	region	region	NN
cord-015684-q10sx1dm	511	12	polymorphism	polymorphism	NN
cord-015684-q10sx1dm	511	13	in	in	IN
cord-015684-q10sx1dm	511	14	the	the	DT
cord-015684-q10sx1dm	511	15	serotonin	serotonin	NN
cord-015684-q10sx1dm	511	16	transporter	transporter	NN
cord-015684-q10sx1dm	511	17	gene	gene	NN
cord-015684-q10sx1dm	511	18	and	and	CC
cord-015684-q10sx1dm	511	19	antidepressant	antidepressant	JJ
cord-015684-q10sx1dm	511	20	response	response	NN
cord-015684-q10sx1dm	511	21	,	,	,
cord-015684-q10sx1dm	511	22	as	as	RB
cord-015684-q10sx1dm	511	23	well	well	RB
cord-015684-q10sx1dm	511	24	as	as	IN
cord-015684-q10sx1dm	511	25	for	for	IN
cord-015684-q10sx1dm	511	26	associations	association	NNS
cord-015684-q10sx1dm	511	27	between	between	IN
cord-015684-q10sx1dm	511	28	candidate	candidate	NN
cord-015684-q10sx1dm	511	29	neurotransmitter	neurotransmitter	NN
cord-015684-q10sx1dm	511	30	receptor	receptor	NN
cord-015684-q10sx1dm	511	31	genes	gene	NNS
cord-015684-q10sx1dm	511	32	and	and	CC
cord-015684-q10sx1dm	511	33	second	second	JJ
cord-015684-q10sx1dm	511	34	generation	generation	NN
cord-015684-q10sx1dm	511	35	antipsychotic	antipsychotic	JJ
cord-015684-q10sx1dm	511	36	drug	drug	NN
cord-015684-q10sx1dm	511	37	response	response	NN
cord-015684-q10sx1dm	511	38	.	.	.
cord-015684-q10sx1dm	512	1	121	121	CD
cord-015684-q10sx1dm	512	2	Polymorphic	polymorphic	JJ
cord-015684-q10sx1dm	512	3	variants	variant	NNS
cord-015684-q10sx1dm	512	4	of	of	IN
cord-015684-q10sx1dm	512	5	several	several	JJ
cord-015684-q10sx1dm	512	6	serotonin	serotonin	NN
cord-015684-q10sx1dm	512	7	receptor	receptor	NN
cord-015684-q10sx1dm	512	8	subtypes	subtype	NNS
cord-015684-q10sx1dm	512	9	seem	seem	VBP
cord-015684-q10sx1dm	512	10	to	to	TO
cord-015684-q10sx1dm	512	11	be	be	VB
cord-015684-q10sx1dm	512	12	involved	involve	VBN
cord-015684-q10sx1dm	512	13	in	in	IN
cord-015684-q10sx1dm	512	14	the	the	DT
cord-015684-q10sx1dm	512	15	efficacy	efficacy	NN
cord-015684-q10sx1dm	512	16	and	and	CC
cord-015684-q10sx1dm	512	17	symptomatic	symptomatic	JJ
cord-015684-q10sx1dm	512	18	response	response	NN
cord-015684-q10sx1dm	512	19	of	of	IN
cord-015684-q10sx1dm	512	20	schizophrenic	schizophrenic	JJ
cord-015684-q10sx1dm	512	21	patients	patient	NNS
cord-015684-q10sx1dm	512	22	to	to	IN
cord-015684-q10sx1dm	512	23	atypical	atypical	JJ
cord-015684-q10sx1dm	512	24	antipsychotics	antipsychotic	NNS
cord-015684-q10sx1dm	512	25	.	.	.
cord-015684-q10sx1dm	513	1	For	for	IN
cord-015684-q10sx1dm	513	2	instance	instance	NN
cord-015684-q10sx1dm	513	3	,	,	,
cord-015684-q10sx1dm	513	4	the	the	DT
cord-015684-q10sx1dm	513	5	−1019	−1019	NNP
cord-015684-q10sx1dm	513	6	C	C	NNP
cord-015684-q10sx1dm	513	7	/	/	SYM
cord-015684-q10sx1dm	513	8	G	g	NN
cord-015684-q10sx1dm	513	9	polymorphism	polymorphism	NN
cord-015684-q10sx1dm	513	10	of	of	IN
cord-015684-q10sx1dm	513	11	the	the	DT
cord-015684-q10sx1dm	513	12	HTR1A	HTR1A	NNP
cord-015684-q10sx1dm	513	13	receptor	receptor	NN
cord-015684-q10sx1dm	513	14	gene	gene	NN
cord-015684-q10sx1dm	513	15	is	be	VBZ
cord-015684-q10sx1dm	513	16	associated	associate	VBN
cord-015684-q10sx1dm	513	17	with	with	IN
cord-015684-q10sx1dm	513	18	negative	negative	JJ
cord-015684-q10sx1dm	513	19	symptom	symptom	NN
cord-015684-q10sx1dm	513	20	response	response	NN
cord-015684-q10sx1dm	513	21	to	to	IN
cord-015684-q10sx1dm	513	22	risperidone	risperidone	NN
cord-015684-q10sx1dm	513	23	in	in	IN
cord-015684-q10sx1dm	513	24	schizophrenics	schizophrenic	NNS
cord-015684-q10sx1dm	513	25	.	.	.
cord-015684-q10sx1dm	514	1	152	152	CD
cord-015684-q10sx1dm	514	2	Interaction	Interaction	NNP
cord-015684-q10sx1dm	514	3	between	between	IN
cord-015684-q10sx1dm	514	4	COMT	COMT	NNP
cord-015684-q10sx1dm	514	5	and	and	CC
cord-015684-q10sx1dm	514	6	NOTCH4	NOTCH4	NNP
cord-015684-q10sx1dm	514	7	genotypes	genotype	NNS
cord-015684-q10sx1dm	514	8	may	may	MD
cord-015684-q10sx1dm	514	9	also	also	RB
cord-015684-q10sx1dm	514	10	predict	predict	VB
cord-015684-q10sx1dm	514	11	the	the	DT
cord-015684-q10sx1dm	514	12	treatment	treatment	NN
cord-015684-q10sx1dm	514	13	response	response	NN
cord-015684-q10sx1dm	514	14	to	to	IN
cord-015684-q10sx1dm	514	15	typical	typical	JJ
cord-015684-q10sx1dm	514	16	neuroleptics	neuroleptic	NNS
cord-015684-q10sx1dm	514	17	in	in	IN
cord-015684-q10sx1dm	514	18	patients	patient	NNS
cord-015684-q10sx1dm	514	19	with	with	IN
cord-015684-q10sx1dm	514	20	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	514	21	.	.	.
cord-015684-q10sx1dm	515	1	153	153	CD
cord-015684-q10sx1dm	516	1	The	the	DT
cord-015684-q10sx1dm	516	2	effi	effi	NNP
cord-015684-q10sx1dm	516	3	cacy	cacy	NNP
cord-015684-q10sx1dm	516	4	of	of	IN
cord-015684-q10sx1dm	516	5	iloperidone	iloperidone	NNP
cord-015684-q10sx1dm	516	6	in	in	IN
cord-015684-q10sx1dm	516	7	patients	patient	NNS
cord-015684-q10sx1dm	516	8	with	with	IN
cord-015684-q10sx1dm	516	9	schizophrenia	schizophrenia	NNP
cord-015684-q10sx1dm	516	10	has	have	VBZ
cord-015684-q10sx1dm	516	11	been	be	VBN
cord-015684-q10sx1dm	516	12	associated	associate	VBN
cord-015684-q10sx1dm	516	13	with	with	IN
cord-015684-q10sx1dm	516	14	the	the	DT
cord-015684-q10sx1dm	516	15	homozygous	homozygous	JJ
cord-015684-q10sx1dm	516	16	condition	condition	NN
cord-015684-q10sx1dm	516	17	for	for	IN
cord-015684-q10sx1dm	516	18	the	the	DT
cord-015684-q10sx1dm	516	19	rs1800169	rs1800169	NNP
cord-015684-q10sx1dm	516	20	G	G	NNP
cord-015684-q10sx1dm	516	21	/	/	SYM
cord-015684-q10sx1dm	516	22	G	g	NN
cord-015684-q10sx1dm	516	23	genotype	genotype	NN
cord-015684-q10sx1dm	516	24	of	of	IN
cord-015684-q10sx1dm	516	25	the	the	DT
cord-015684-q10sx1dm	516	26	ciliary	ciliary	NN
cord-015684-q10sx1dm	516	27	neurotrophic	neurotrophic	NN
cord-015684-q10sx1dm	516	28	factor	factor	NN
cord-015684-q10sx1dm	516	29	(	(	-LRB-
cord-015684-q10sx1dm	516	30	CNTF	CNTF	NNP
cord-015684-q10sx1dm	516	31	)	)	-RRB-
cord-015684-q10sx1dm	516	32	gene	gene	NN
cord-015684-q10sx1dm	516	33	.	.	.
cord-015684-q10sx1dm	517	1	154	154	CD
cord-015684-q10sx1dm	517	2	Dopamine	dopamine	NN
cord-015684-q10sx1dm	517	3	receptor	receptor	NN
cord-015684-q10sx1dm	517	4	interacting	interact	VBG
cord-015684-q10sx1dm	517	5	proteins	protein	NNS
cord-015684-q10sx1dm	517	6	(	(	-LRB-
cord-015684-q10sx1dm	517	7	DRIPs	drip	NNS
cord-015684-q10sx1dm	517	8	)	)	-RRB-
cord-015684-q10sx1dm	517	9	are	be	VBP
cord-015684-q10sx1dm	517	10	pivotally	pivotally	RB
cord-015684-q10sx1dm	517	11	involved	involve	VBN
cord-015684-q10sx1dm	517	12	in	in	IN
cord-015684-q10sx1dm	517	13	regulating	regulate	VBG
cord-015684-q10sx1dm	517	14	dopamine	dopamine	NN
cord-015684-q10sx1dm	517	15	receptor	receptor	NN
cord-015684-q10sx1dm	517	16	signal	signal	NN
cord-015684-q10sx1dm	517	17	transduction	transduction	NN
cord-015684-q10sx1dm	517	18	.	.	.
cord-015684-q10sx1dm	518	1	Two	two	CD
cord-015684-q10sx1dm	518	2	SNPs	snp	NNS
cord-015684-q10sx1dm	518	3	in	in	IN
cord-015684-q10sx1dm	518	4	the	the	DT
cord-015684-q10sx1dm	518	5	dopamine	dopamine	NN
cord-015684-q10sx1dm	518	6	receptor	receptor	NN
cord-015684-q10sx1dm	518	7	interacting	interact	VBG
cord-015684-q10sx1dm	518	8	protein	protein	NN
cord-015684-q10sx1dm	518	9	gene	gene	NN
cord-015684-q10sx1dm	518	10	,	,	,
cord-015684-q10sx1dm	518	11	NEF3	NEF3	NNP
cord-015684-q10sx1dm	518	12	,	,	,
cord-015684-q10sx1dm	518	13	which	which	WDT
cord-015684-q10sx1dm	518	14	encodes	encode	VBZ
cord-015684-q10sx1dm	518	15	the	the	DT
cord-015684-q10sx1dm	518	16	DRIP	drip	NN
cord-015684-q10sx1dm	518	17	,	,	,
cord-015684-q10sx1dm	518	18	neurofi	neurofi	NNP
cord-015684-q10sx1dm	518	19	lament	lament	NN
cord-015684-q10sx1dm	518	20	-	-	HYPH
cord-015684-q10sx1dm	518	21	medium	medium	NN
cord-015684-q10sx1dm	518	22	(	(	-LRB-
cord-015684-q10sx1dm	518	23	NF	NF	NNP
cord-015684-q10sx1dm	518	24	-	-	HYPH
cord-015684-q10sx1dm	518	25	M	M	NNP
cord-015684-q10sx1dm	518	26	)	)	-RRB-
cord-015684-q10sx1dm	518	27	,	,	,
cord-015684-q10sx1dm	518	28	were	be	VBD
cord-015684-q10sx1dm	518	29	associated	associate	VBN
cord-015684-q10sx1dm	518	30	with	with	IN
cord-015684-q10sx1dm	518	31	early	early	JJ
cord-015684-q10sx1dm	518	32	response	response	NN
cord-015684-q10sx1dm	518	33	(	(	-LRB-
cord-015684-q10sx1dm	518	34	rs1457266	rs1457266	NNP
cord-015684-q10sx1dm	518	35	,	,	,
cord-015684-q10sx1dm	518	36	rs1379357	rs1379357	NNP
cord-015684-q10sx1dm	518	37	)	)	-RRB-
cord-015684-q10sx1dm	518	38	.	.	.
cord-015684-q10sx1dm	519	1	A	a	DT
cord-015684-q10sx1dm	519	2	5	5	CD
cord-015684-q10sx1dm	519	3	SNP	SNP	NNP
cord-015684-q10sx1dm	519	4	haplotype	haplotype	NN
cord-015684-q10sx1dm	519	5	spanning	span	VBG
cord-015684-q10sx1dm	519	6	NEF3	NEF3	NNP
cord-015684-q10sx1dm	519	7	was	be	VBD
cord-015684-q10sx1dm	519	8	over	over	RB
cord-015684-q10sx1dm	519	9	-	-	HYPH
cord-015684-q10sx1dm	519	10	represented	represent	VBN
cord-015684-q10sx1dm	519	11	in	in	IN
cord-015684-q10sx1dm	519	12	early	early	JJ
cord-015684-q10sx1dm	519	13	responders	responder	NNS
cord-015684-q10sx1dm	519	14	.	.	.
cord-015684-q10sx1dm	520	1	Since	since	IN
cord-015684-q10sx1dm	520	2	NEF3	NEF3	NNP
cord-015684-q10sx1dm	520	3	is	be	VBZ
cord-015684-q10sx1dm	520	4	primarily	primarily	RB
cord-015684-q10sx1dm	520	5	associated	associate	VBN
cord-015684-q10sx1dm	520	6	with	with	IN
cord-015684-q10sx1dm	520	7	dopamine	dopamine	NN
cord-015684-q10sx1dm	520	8	D1	d1	NN
cord-015684-q10sx1dm	520	9	receptor	receptor	NN
cord-015684-q10sx1dm	520	10	function	function	NN
cord-015684-q10sx1dm	520	11	,	,	,
cord-015684-q10sx1dm	520	12	it	-PRON-	PRP
cord-015684-q10sx1dm	520	13	is	be	VBZ
cord-015684-q10sx1dm	520	14	likely	likely	JJ
cord-015684-q10sx1dm	520	15	that	that	IN
cord-015684-q10sx1dm	520	16	both	both	DT
cord-015684-q10sx1dm	520	17	genes	gene	NNS
cord-015684-q10sx1dm	520	18	cooperate	cooperate	VBP
cord-015684-q10sx1dm	520	19	in	in	IN
cord-015684-q10sx1dm	520	20	eliciting	elicit	VBG
cord-015684-q10sx1dm	520	21	genotype	genotype	NN
cord-015684-q10sx1dm	520	22	-	-	HYPH
cord-015684-q10sx1dm	520	23	specifi	specifi	VBN
cord-015684-q10sx1dm	520	24	c	c	NN
cord-015684-q10sx1dm	520	25	antipsychotic	antipsychotic	JJ
cord-015684-q10sx1dm	520	26	response	response	NN
cord-015684-q10sx1dm	520	27	.	.	.
cord-015684-q10sx1dm	521	1	155	155	CD
cord-015684-q10sx1dm	522	1	The	the	DT
cord-015684-q10sx1dm	522	2	improvement	improvement	NN
cord-015684-q10sx1dm	522	3	in	in	IN
cord-015684-q10sx1dm	522	4	the	the	DT
cord-015684-q10sx1dm	522	5	Positive	positive	JJ
cord-015684-q10sx1dm	522	6	and	and	CC
cord-015684-q10sx1dm	522	7	Negative	negative	JJ
cord-015684-q10sx1dm	522	8	Syndrome	syndrome	NN
cord-015684-q10sx1dm	522	9	Scale	scale	NN
cord-015684-q10sx1dm	522	10	(	(	-LRB-
cord-015684-q10sx1dm	522	11	PANSS	PANSS	NNP
cord-015684-q10sx1dm	522	12	)	)	-RRB-
cord-015684-q10sx1dm	522	13	positive	positive	JJ
cord-015684-q10sx1dm	522	14	subscore	subscore	NN
cord-015684-q10sx1dm	522	15	was	be	VBD
cord-015684-q10sx1dm	522	16	found	find	VBN
cord-015684-q10sx1dm	522	17	signifi	signifi	NNP
cord-015684-q10sx1dm	522	18	cantly	cantly	RB
cord-015684-q10sx1dm	522	19	greater	great	JJR
cord-015684-q10sx1dm	522	20	in	in	IN
cord-015684-q10sx1dm	522	21	patients	patient	NNS
cord-015684-q10sx1dm	522	22	homozygous	homozygous	JJ
cord-015684-q10sx1dm	522	23	for	for	IN
cord-015684-q10sx1dm	522	24	the	the	DT
cord-015684-q10sx1dm	522	25	A1287	A1287	NNP
cord-015684-q10sx1dm	522	26	allele	allele	NN
cord-015684-q10sx1dm	522	27	of	of	IN
cord-015684-q10sx1dm	522	28	the	the	DT
cord-015684-q10sx1dm	522	29	SLC6A2	SLC6A2	NNP
cord-015684-q10sx1dm	522	30	(	(	-LRB-
cord-015684-q10sx1dm	522	31	Solute	Solute	NNP
cord-015684-q10sx1dm	522	32	Carrier	Carrier	NNP
cord-015684-q10sx1dm	522	33	Family	Family	NNP
cord-015684-q10sx1dm	522	34	6	6	CD
cord-015684-q10sx1dm	522	35	(	(	-LRB-
cord-015684-q10sx1dm	522	36	Noradrenaline	Noradrenaline	NNP
cord-015684-q10sx1dm	522	37	Transporter	Transporter	NNP
cord-015684-q10sx1dm	522	38	)	)	-RRB-
cord-015684-q10sx1dm	522	39	,	,	,
cord-015684-q10sx1dm	522	40	Member	Member	NNP
cord-015684-q10sx1dm	522	41	2	2	CD
cord-015684-q10sx1dm	522	42	)	)	-RRB-
cord-015684-q10sx1dm	522	43	gene	gene	NN
cord-015684-q10sx1dm	522	44	,	,	,
cord-015684-q10sx1dm	522	45	and	and	CC
cord-015684-q10sx1dm	522	46	smaller	small	JJR
cord-015684-q10sx1dm	522	47	in	in	IN
cord-015684-q10sx1dm	522	48	patients	patient	NNS
cord-015684-q10sx1dm	522	49	homozygous	homozygous	JJ
cord-015684-q10sx1dm	522	50	for	for	IN
cord-015684-q10sx1dm	522	51	the	the	DT
cord-015684-q10sx1dm	522	52	C-182	c-182	NN
cord-015684-q10sx1dm	522	53	allele	allele	NN
cord-015684-q10sx1dm	522	54	of	of	IN
cord-015684-q10sx1dm	522	55	the	the	DT
cord-015684-q10sx1dm	522	56	SLC6A2	SLC6A2	NNP
cord-015684-q10sx1dm	522	57	gene	gene	NN
cord-015684-q10sx1dm	522	58	,	,	,
cord-015684-q10sx1dm	522	59	suggesting	suggest	VBG
cord-015684-q10sx1dm	522	60	that	that	IN
cord-015684-q10sx1dm	522	61	these	these	DT
cord-015684-q10sx1dm	522	62	polymorphisms	polymorphism	NNS
cord-015684-q10sx1dm	522	63	of	of	IN
cord-015684-q10sx1dm	522	64	the	the	DT
cord-015684-q10sx1dm	522	65	noradrenaline	noradrenaline	NN
cord-015684-q10sx1dm	522	66	transporter	transporter	NN
cord-015684-q10sx1dm	522	67	gene	gene	NN
cord-015684-q10sx1dm	522	68	are	be	VBP
cord-015684-q10sx1dm	522	69	specifi	specifi	VBN
cord-015684-q10sx1dm	522	70	cally	cally	RB
cord-015684-q10sx1dm	522	71	involved	involve	VBN
cord-015684-q10sx1dm	522	72	in	in	IN
cord-015684-q10sx1dm	522	73	the	the	DT
cord-015684-q10sx1dm	522	74	variation	variation	NN
cord-015684-q10sx1dm	522	75	of	of	IN
cord-015684-q10sx1dm	522	76	positive	positive	JJ
cord-015684-q10sx1dm	522	77	symptoms	symptom	NNS
cord-015684-q10sx1dm	522	78	in	in	IN
cord-015684-q10sx1dm	522	79	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	522	80	.	.	.
cord-015684-q10sx1dm	523	1	156	156	CD
cord-015684-q10sx1dm	523	2	Weight	weight	NN
cord-015684-q10sx1dm	523	3	gain	gain	NN
cord-015684-q10sx1dm	523	4	is	be	VBZ
cord-015684-q10sx1dm	523	5	a	a	DT
cord-015684-q10sx1dm	523	6	problem	problem	NN
cord-015684-q10sx1dm	523	7	commonly	commonly	RB
cord-015684-q10sx1dm	523	8	found	find	VBN
cord-015684-q10sx1dm	523	9	in	in	IN
cord-015684-q10sx1dm	523	10	patients	patient	NNS
cord-015684-q10sx1dm	523	11	treated	treat	VBN
cord-015684-q10sx1dm	523	12	with	with	IN
cord-015684-q10sx1dm	523	13	neuroleptics	neuroleptic	NNS
cord-015684-q10sx1dm	523	14	,	,	,
cord-015684-q10sx1dm	523	15	tricyclic	tricyclic	NN
cord-015684-q10sx1dm	523	16	antidepressants	antidepressant	NNS
cord-015684-q10sx1dm	523	17	,	,	,
cord-015684-q10sx1dm	523	18	and	and	CC
cord-015684-q10sx1dm	523	19	some	some	DT
cord-015684-q10sx1dm	523	20	antiepileptics	antiepileptic	NNS
cord-015684-q10sx1dm	523	21	(	(	-LRB-
cord-015684-q10sx1dm	523	22	e.g.	e.g.	RB
cord-015684-q10sx1dm	523	23	,	,	,
cord-015684-q10sx1dm	523	24	valproic	valproic	NN
cord-015684-q10sx1dm	523	25	acid	acid	NN
cord-015684-q10sx1dm	523	26	)	)	-RRB-
cord-015684-q10sx1dm	523	27	.	.	.
cord-015684-q10sx1dm	524	1	The	the	DT
cord-015684-q10sx1dm	524	2	adipocyte	adipocyte	NN
cord-015684-q10sx1dm	524	3	-	-	HYPH
cord-015684-q10sx1dm	524	4	derived	derive	VBN
cord-015684-q10sx1dm	524	5	hormone	hormone	NN
cord-015684-q10sx1dm	524	6	,	,	,
cord-015684-q10sx1dm	524	7	leptin	leptin	NN
cord-015684-q10sx1dm	524	8	,	,	,
cord-015684-q10sx1dm	524	9	has	have	VBZ
cord-015684-q10sx1dm	524	10	been	be	VBN
cord-015684-q10sx1dm	524	11	associated	associate	VBN
cord-015684-q10sx1dm	524	12	with	with	IN
cord-015684-q10sx1dm	524	13	body	body	NN
cord-015684-q10sx1dm	524	14	weight	weight	NN
cord-015684-q10sx1dm	524	15	and	and	CC
cord-015684-q10sx1dm	524	16	energy	energy	NN
cord-015684-q10sx1dm	524	17	homeostasis	homeostasis	NN
cord-015684-q10sx1dm	524	18	,	,	,
cord-015684-q10sx1dm	524	19	and	and	CC
cord-015684-q10sx1dm	524	20	abnormal	abnormal	JJ
cord-015684-q10sx1dm	524	21	regulation	regulation	NN
cord-015684-q10sx1dm	524	22	of	of	IN
cord-015684-q10sx1dm	524	23	leptin	leptin	NN
cord-015684-q10sx1dm	524	24	could	could	MD
cord-015684-q10sx1dm	524	25	play	play	VB
cord-015684-q10sx1dm	524	26	a	a	DT
cord-015684-q10sx1dm	524	27	role	role	NN
cord-015684-q10sx1dm	524	28	in	in	IN
cord-015684-q10sx1dm	524	29	weight	weight	NN
cord-015684-q10sx1dm	524	30	gain	gain	NN
cord-015684-q10sx1dm	524	31	induced	induce	VBN
cord-015684-q10sx1dm	524	32	by	by	IN
cord-015684-q10sx1dm	524	33	antipsychotics	antipsychotic	NNS
cord-015684-q10sx1dm	524	34	.	.	.
cord-015684-q10sx1dm	525	1	The	the	DT
cord-015684-q10sx1dm	525	2	leptin	leptin	NN
cord-015684-q10sx1dm	525	3	gene	gene	NN
cord-015684-q10sx1dm	525	4	promoter	promoter	NN
cord-015684-q10sx1dm	525	5	variant	variant	NN
cord-015684-q10sx1dm	525	6	G2548A	G2548A	NNP
cord-015684-q10sx1dm	525	7	was	be	VBD
cord-015684-q10sx1dm	525	8	associated	associate	VBN
cord-015684-q10sx1dm	525	9	with	with	IN
cord-015684-q10sx1dm	525	10	clozapine	clozapine	NN
cord-015684-q10sx1dm	525	11	-	-	HYPH
cord-015684-q10sx1dm	525	12	induced	induce	VBN
cord-015684-q10sx1dm	525	13	weight	weight	NN
cord-015684-q10sx1dm	525	14	in	in	IN
cord-015684-q10sx1dm	525	15	Chinese	chinese	JJ
cord-015684-q10sx1dm	525	16	patients	patient	NNS
cord-015684-q10sx1dm	525	17	with	with	IN
cord-015684-q10sx1dm	525	18	chronic	chronic	JJ
cord-015684-q10sx1dm	525	19	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	525	20	.	.	.
cord-015684-q10sx1dm	526	1	157	157	CD
cord-015684-q10sx1dm	527	1	Likewise	likewise	RB
cord-015684-q10sx1dm	527	2	,	,	,
cord-015684-q10sx1dm	527	3	studies	study	NNS
cord-015684-q10sx1dm	527	4	in	in	IN
cord-015684-q10sx1dm	527	5	Caucasians	Caucasians	NNPS
cord-015684-q10sx1dm	527	6	suggest	suggest	VBP
cord-015684-q10sx1dm	527	7	that	that	IN
cord-015684-q10sx1dm	527	8	genetic	genetic	JJ
cord-015684-q10sx1dm	527	9	vulnerability	vulnerability	NN
cord-015684-q10sx1dm	527	10	in	in	IN
cord-015684-q10sx1dm	527	11	the	the	DT
cord-015684-q10sx1dm	527	12	leptin	leptin	NN
cord-015684-q10sx1dm	527	13	gene	gene	NN
cord-015684-q10sx1dm	527	14	(	(	-LRB-
cord-015684-q10sx1dm	527	15	−1548G	−1548G	NNP
cord-015684-q10sx1dm	527	16	/	/	SYM
cord-015684-q10sx1dm	527	17	A	A	NNP
cord-015684-q10sx1dm	527	18	)	)	-RRB-
cord-015684-q10sx1dm	527	19	and	and	CC
cord-015684-q10sx1dm	527	20	leptin	leptin	NN
cord-015684-q10sx1dm	527	21	receptor	receptor	NN
cord-015684-q10sx1dm	527	22	(	(	-LRB-
cord-015684-q10sx1dm	527	23	Q223R	Q223R	NNP
cord-015684-q10sx1dm	527	24	)	)	-RRB-
cord-015684-q10sx1dm	527	25	may	may	MD
cord-015684-q10sx1dm	527	26	predispose	predispose	VB
cord-015684-q10sx1dm	527	27	some	some	DT
cord-015684-q10sx1dm	527	28	individuals	individual	NNS
cord-015684-q10sx1dm	527	29	to	to	IN
cord-015684-q10sx1dm	527	30	excessive	excessive	JJ
cord-015684-q10sx1dm	527	31	weight	weight	NN
cord-015684-q10sx1dm	527	32	gain	gain	NN
cord-015684-q10sx1dm	527	33	from	from	IN
cord-015684-q10sx1dm	527	34	increased	increase	VBN
cord-015684-q10sx1dm	527	35	exposure	exposure	NN
cord-015684-q10sx1dm	527	36	to	to	IN
cord-015684-q10sx1dm	527	37	olanzapine	olanzapine	NNP
cord-015684-q10sx1dm	527	38	.	.	.
cord-015684-q10sx1dm	528	1	158	158	CD
cord-015684-q10sx1dm	528	2	,	,	,
cord-015684-q10sx1dm	528	3	159	159	CD
cord-015684-q10sx1dm	529	1	The	the	DT
cord-015684-q10sx1dm	529	2	development	development	NN
cord-015684-q10sx1dm	529	3	of	of	IN
cord-015684-q10sx1dm	529	4	selective	selective	JJ
cord-015684-q10sx1dm	529	5	type	type	NN
cord-015684-q10sx1dm	529	6	5	5	CD
cord-015684-q10sx1dm	529	7	metabotropic	metabotropic	NN
cord-015684-q10sx1dm	529	8	glutamate	glutamate	NN
cord-015684-q10sx1dm	529	9	receptor	receptor	NN
cord-015684-q10sx1dm	529	10	(	(	-LRB-
cord-015684-q10sx1dm	529	11	mGlu5	mGlu5	NNP
cord-015684-q10sx1dm	529	12	)	)	-RRB-
cord-015684-q10sx1dm	529	13	antagonists	antagonist	NNS
cord-015684-q10sx1dm	529	14	,	,	,
cord-015684-q10sx1dm	529	15	such	such	JJ
cord-015684-q10sx1dm	529	16	as	as	IN
cord-015684-q10sx1dm	529	17	2-methyl-6-(phenylethynyl)-pyridine	2-methyl-6-(phenylethynyl)-pyridine	CD
cord-015684-q10sx1dm	529	18	(	(	-LRB-
cord-015684-q10sx1dm	529	19	MPEP	MPEP	NNP
cord-015684-q10sx1dm	529	20	)	)	-RRB-
cord-015684-q10sx1dm	529	21	and	and	CC
cord-015684-q10sx1dm	529	22	3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine	3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine	CD
cord-015684-q10sx1dm	529	23	(	(	-LRB-
cord-015684-q10sx1dm	529	24	MTEP	MTEP	NNP
cord-015684-q10sx1dm	529	25	)	)	-RRB-
cord-015684-q10sx1dm	529	26	,	,	,
cord-015684-q10sx1dm	529	27	has	have	VBZ
cord-015684-q10sx1dm	529	28	demonstrated	demonstrate	VBN
cord-015684-q10sx1dm	529	29	the	the	DT
cord-015684-q10sx1dm	529	30	potential	potential	JJ
cord-015684-q10sx1dm	529	31	involvement	involvement	NN
cord-015684-q10sx1dm	529	32	of	of	IN
cord-015684-q10sx1dm	529	33	these	these	DT
cord-015684-q10sx1dm	529	34	receptors	receptor	NNS
cord-015684-q10sx1dm	529	35	in	in	IN
cord-015684-q10sx1dm	529	36	several	several	JJ
cord-015684-q10sx1dm	529	37	CNS	CNS	NNP
cord-015684-q10sx1dm	529	38	disorders	disorder	NNS
cord-015684-q10sx1dm	529	39	including	include	VBG
cord-015684-q10sx1dm	529	40	depression	depression	NN
cord-015684-q10sx1dm	529	41	,	,	,
cord-015684-q10sx1dm	529	42	anxiety	anxiety	NN
cord-015684-q10sx1dm	529	43	,	,	,
cord-015684-q10sx1dm	529	44	epilepsy	epilepsy	NN
cord-015684-q10sx1dm	529	45	,	,	,
cord-015684-q10sx1dm	529	46	Parkinson	Parkinson	NNP
cord-015684-q10sx1dm	529	47	's	's	POS
cord-015684-q10sx1dm	529	48	disease	disease	NN
cord-015684-q10sx1dm	529	49	,	,	,
cord-015684-q10sx1dm	529	50	drug	drug	NN
cord-015684-q10sx1dm	529	51	addiction	addiction	NN
cord-015684-q10sx1dm	529	52	,	,	,
cord-015684-q10sx1dm	529	53	and	and	CC
cord-015684-q10sx1dm	529	54	alcoholism	alcoholism	NN
cord-015684-q10sx1dm	529	55	.	.	.
cord-015684-q10sx1dm	530	1	Treatment	treatment	NN
cord-015684-q10sx1dm	530	2	with	with	IN
cord-015684-q10sx1dm	530	3	MPEP	MPEP	NNP
cord-015684-q10sx1dm	530	4	and	and	CC
cord-015684-q10sx1dm	530	5	MTEP	MTEP	NNP
cord-015684-q10sx1dm	530	6	can	can	MD
cord-015684-q10sx1dm	530	7	induce	induce	VB
cord-015684-q10sx1dm	530	8	gene	gene	NN
cord-015684-q10sx1dm	530	9	expression	expression	NN
cord-015684-q10sx1dm	530	10	related	relate	VBN
cord-015684-q10sx1dm	530	11	to	to	IN
cord-015684-q10sx1dm	530	12	ATP	ATP	NNP
cord-015684-q10sx1dm	530	13	synthesis	synthesis	NN
cord-015684-q10sx1dm	530	14	,	,	,
cord-015684-q10sx1dm	530	15	hydrolase	hydrolase	NN
cord-015684-q10sx1dm	530	16	activity	activity	NN
cord-015684-q10sx1dm	530	17	,	,	,
cord-015684-q10sx1dm	530	18	and	and	CC
cord-015684-q10sx1dm	530	19	signaling	signal	VBG
cord-015684-q10sx1dm	530	20	pathways	pathway	NNS
cord-015684-q10sx1dm	530	21	associated	associate	VBN
cord-015684-q10sx1dm	530	22	with	with	IN
cord-015684-q10sx1dm	530	23	mitogen	mitogen	NN
cord-015684-q10sx1dm	530	24	-	-	HYPH
cord-015684-q10sx1dm	530	25	activated	activate	VBN
cord-015684-q10sx1dm	530	26	protein	protein	NN
cord-015684-q10sx1dm	530	27	kinase	kinase	NN
cord-015684-q10sx1dm	530	28	(	(	-LRB-
cord-015684-q10sx1dm	530	29	MAPK	MAPK	NNP
cord-015684-q10sx1dm	530	30	)	)	-RRB-
cord-015684-q10sx1dm	530	31	in	in	IN
cord-015684-q10sx1dm	530	32	the	the	DT
cord-015684-q10sx1dm	530	33	frontal	frontal	JJ
cord-015684-q10sx1dm	530	34	cortex	cortex	NN
cord-015684-q10sx1dm	530	35	,	,	,
cord-015684-q10sx1dm	530	36	this	this	DT
cord-015684-q10sx1dm	530	37	constituting	constitute	VBG
cord-015684-q10sx1dm	530	38	another	another	DT
cord-015684-q10sx1dm	530	39	potential	potential	JJ
cord-015684-q10sx1dm	530	40	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	530	41	target	target	NN
cord-015684-q10sx1dm	530	42	in	in	IN
cord-015684-q10sx1dm	530	43	some	some	DT
cord-015684-q10sx1dm	530	44	neuropsychiatric	neuropsychiatric	JJ
cord-015684-q10sx1dm	530	45	disorders	disorder	NNS
cord-015684-q10sx1dm	530	46	.	.	.
cord-015684-q10sx1dm	531	1	160	160	CD
cord-015684-q10sx1dm	532	1	A	a	DT
cord-015684-q10sx1dm	532	2	new	new	JJ
cord-015684-q10sx1dm	532	3	marker	marker	NN
cord-015684-q10sx1dm	532	4	(	(	-LRB-
cord-015684-q10sx1dm	532	5	rs1954787	rs1954787	NNP
cord-015684-q10sx1dm	532	6	)	)	-RRB-
cord-015684-q10sx1dm	532	7	in	in	IN
cord-015684-q10sx1dm	532	8	the	the	DT
cord-015684-q10sx1dm	532	9	GRIK4	GRIK4	NNP
cord-015684-q10sx1dm	532	10	gene	gene	NN
cord-015684-q10sx1dm	532	11	,	,	,
cord-015684-q10sx1dm	532	12	which	which	WDT
cord-015684-q10sx1dm	532	13	codes	code	VBZ
cord-015684-q10sx1dm	532	14	for	for	IN
cord-015684-q10sx1dm	532	15	the	the	DT
cord-015684-q10sx1dm	532	16	kainic	kainic	NNP
cord-015684-q10sx1dm	532	17	acid	acid	NN
cord-015684-q10sx1dm	532	18	-	-	HYPH
cord-015684-q10sx1dm	532	19	type	type	NN
cord-015684-q10sx1dm	532	20	glutamate	glutamate	NN
cord-015684-q10sx1dm	532	21	receptor	receptor	NN
cord-015684-q10sx1dm	532	22	KA1	KA1	NNP
cord-015684-q10sx1dm	532	23	,	,	,
cord-015684-q10sx1dm	532	24	has	have	VBZ
cord-015684-q10sx1dm	532	25	been	be	VBN
cord-015684-q10sx1dm	532	26	associated	associate	VBN
cord-015684-q10sx1dm	532	27	with	with	IN
cord-015684-q10sx1dm	532	28	response	response	NN
cord-015684-q10sx1dm	532	29	to	to	IN
cord-015684-q10sx1dm	532	30	the	the	DT
cord-015684-q10sx1dm	532	31	antidepressant	antidepressant	NN
cord-015684-q10sx1dm	532	32	citalopram	citalopram	NNP
cord-015684-q10sx1dm	532	33	,	,	,
cord-015684-q10sx1dm	532	34	suggesting	suggest	VBG
cord-015684-q10sx1dm	532	35	that	that	IN
cord-015684-q10sx1dm	532	36	the	the	DT
cord-015684-q10sx1dm	532	37	glutamate	glutamate	NN
cord-015684-q10sx1dm	532	38	system	system	NN
cord-015684-q10sx1dm	532	39	plays	play	VBZ
cord-015684-q10sx1dm	532	40	a	a	DT
cord-015684-q10sx1dm	532	41	role	role	NN
cord-015684-q10sx1dm	532	42	in	in	IN
cord-015684-q10sx1dm	532	43	modulating	modulate	VBG
cord-015684-q10sx1dm	532	44	response	response	NN
cord-015684-q10sx1dm	532	45	to	to	IN
cord-015684-q10sx1dm	532	46	selective	selective	JJ
cord-015684-q10sx1dm	532	47	serotonin	serotonin	NN
cord-015684-q10sx1dm	532	48	reuptake	reuptake	NN
cord-015684-q10sx1dm	532	49	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	532	50	(	(	-LRB-
cord-015684-q10sx1dm	532	51	SSRIs	ssri	NNS
cord-015684-q10sx1dm	532	52	)	)	-RRB-
cord-015684-q10sx1dm	532	53	.	.	.
cord-015684-q10sx1dm	533	1	161	161	CD
cord-015684-q10sx1dm	533	2	Glycogen	Glycogen	NNP
cord-015684-q10sx1dm	533	3	synthase	synthase	NN
cord-015684-q10sx1dm	533	4	kinase-3β	kinase-3β	NNP
cord-015684-q10sx1dm	533	5	(	(	-LRB-
cord-015684-q10sx1dm	533	6	GSK3B	GSK3B	NNS
cord-015684-q10sx1dm	533	7	)	)	-RRB-
cord-015684-q10sx1dm	533	8	activity	activity	NN
cord-015684-q10sx1dm	533	9	is	be	VBZ
cord-015684-q10sx1dm	533	10	increased	increase	VBN
cord-015684-q10sx1dm	533	11	in	in	IN
cord-015684-q10sx1dm	533	12	the	the	DT
cord-015684-q10sx1dm	533	13	brain	brain	NN
cord-015684-q10sx1dm	533	14	of	of	IN
cord-015684-q10sx1dm	533	15	patients	patient	NNS
cord-015684-q10sx1dm	533	16	with	with	IN
cord-015684-q10sx1dm	533	17	major	major	JJ
cord-015684-q10sx1dm	533	18	depressive	depressive	JJ
cord-015684-q10sx1dm	533	19	disorders	disorder	NNS
cord-015684-q10sx1dm	533	20	.	.	.
cord-015684-q10sx1dm	534	1	Inhibition	inhibition	NN
cord-015684-q10sx1dm	534	2	of	of	IN
cord-015684-q10sx1dm	534	3	GSK3B	GSK3B	NNS
cord-015684-q10sx1dm	534	4	is	be	VBZ
cord-015684-q10sx1dm	534	5	thought	think	VBN
cord-015684-q10sx1dm	534	6	to	to	TO
cord-015684-q10sx1dm	534	7	be	be	VB
cord-015684-q10sx1dm	534	8	a	a	DT
cord-015684-q10sx1dm	534	9	key	key	JJ
cord-015684-q10sx1dm	534	10	feature	feature	NN
cord-015684-q10sx1dm	534	11	in	in	IN
cord-015684-q10sx1dm	534	12	the	the	DT
cord-015684-q10sx1dm	534	13	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	534	14	mechanism	mechanism	NN
cord-015684-q10sx1dm	534	15	of	of	IN
cord-015684-q10sx1dm	534	16	antidepressants	antidepressant	NNS
cord-015684-q10sx1dm	534	17	.	.	.
cord-015684-q10sx1dm	535	1	Four	four	CD
cord-015684-q10sx1dm	535	2	polymorphisms	polymorphism	NNS
cord-015684-q10sx1dm	535	3	of	of	IN
cord-015684-q10sx1dm	535	4	the	the	DT
cord-015684-q10sx1dm	535	5	GSK3B	GSK3B	NNS
cord-015684-q10sx1dm	535	6	gene	gene	NN
cord-015684-q10sx1dm	535	7	[	[	-LRB-
cord-015684-q10sx1dm	535	8	rs334555	rs334555	NNP
cord-015684-q10sx1dm	535	9	(	(	-LRB-
cord-015684-q10sx1dm	535	10	−50	−50	NNP
cord-015684-q10sx1dm	535	11	T	t	NN
cord-015684-q10sx1dm	535	12	>	>	XX
cord-015684-q10sx1dm	535	13	C	c	NN
cord-015684-q10sx1dm	535	14	)	)	-RRB-
cord-015684-q10sx1dm	535	15	;	;	:
cord-015684-q10sx1dm	535	16	rs13321783	rs13321783	FW
cord-015684-q10sx1dm	535	17	(	(	-LRB-
cord-015684-q10sx1dm	535	18	IVS7	IVS7	NNP
cord-015684-q10sx1dm	535	19	+	+	SYM
cord-015684-q10sx1dm	535	20	9227	9227	CD
cord-015684-q10sx1dm	535	21	A	a	NN
cord-015684-q10sx1dm	535	22	>	>	XX
cord-015684-q10sx1dm	535	23	G	g	NN
cord-015684-q10sx1dm	535	24	)	)	-RRB-
cord-015684-q10sx1dm	535	25	;	;	:
cord-015684-q10sx1dm	535	26	rs2319398	rs2319398	.
cord-015684-q10sx1dm	535	27	(	(	-LRB-
cord-015684-q10sx1dm	535	28	IVS	IVS	NNP
cord-015684-q10sx1dm	535	29	+	+	SYM
cord-015684-q10sx1dm	535	30	11660	11660	CD
cord-015684-q10sx1dm	535	31	G	g	NN
cord-015684-q10sx1dm	535	32	>	>	XX
cord-015684-q10sx1dm	535	33	T	t	NN
cord-015684-q10sx1dm	535	34	)	)	-RRB-
cord-015684-q10sx1dm	535	35	;	;	.
cord-015684-q10sx1dm	536	1	rs6808874	rs6808874	LS
cord-015684-q10sx1dm	536	2	(	(	-LRB-
cord-015684-q10sx1dm	536	3	IVS	IVS	NNP
cord-015684-q10sx1dm	536	4	+	+	SYM
cord-015684-q10sx1dm	536	5	4251	4251	CD
cord-015684-q10sx1dm	536	6	T	t	NN
cord-015684-q10sx1dm	536	7	>	>	XX
cord-015684-q10sx1dm	536	8	A	a	NN
cord-015684-q10sx1dm	536	9	)	)	-RRB-
cord-015684-q10sx1dm	536	10	]	]	-RRB-
cord-015684-q10sx1dm	536	11	have	have	VBP
cord-015684-q10sx1dm	536	12	been	be	VBN
cord-015684-q10sx1dm	536	13	genotyped	genotype	VBN
cord-015684-q10sx1dm	536	14	in	in	IN
cord-015684-q10sx1dm	536	15	Chinese	chinese	JJ
cord-015684-q10sx1dm	536	16	patients	patient	NNS
cord-015684-q10sx1dm	536	17	with	with	IN
cord-015684-q10sx1dm	536	18	major	major	JJ
cord-015684-q10sx1dm	536	19	depression	depression	NN
cord-015684-q10sx1dm	536	20	.	.	.
cord-015684-q10sx1dm	537	1	GSK3B	GSK3B	NNS
cord-015684-q10sx1dm	538	1	TAGT	TAGT	NNP
cord-015684-q10sx1dm	538	2	carriers	carrier	NNS
cord-015684-q10sx1dm	538	3	showed	show	VBD
cord-015684-q10sx1dm	538	4	poorer	poor	JJR
cord-015684-q10sx1dm	538	5	response	response	NN
cord-015684-q10sx1dm	538	6	to	to	IN
cord-015684-q10sx1dm	538	7	antidepressants	antidepressant	NNS
cord-015684-q10sx1dm	538	8	.	.	.
cord-015684-q10sx1dm	539	1	162	162	CD
cord-015684-q10sx1dm	539	2	Lithium	Lithium	NNP
cord-015684-q10sx1dm	539	3	has	have	VBZ
cord-015684-q10sx1dm	539	4	been	be	VBN
cord-015684-q10sx1dm	539	5	used	use	VBN
cord-015684-q10sx1dm	539	6	for	for	IN
cord-015684-q10sx1dm	539	7	over	over	IN
cord-015684-q10sx1dm	539	8	40	40	CD
cord-015684-q10sx1dm	539	9	years	year	NNS
cord-015684-q10sx1dm	539	10	as	as	IN
cord-015684-q10sx1dm	539	11	an	an	DT
cord-015684-q10sx1dm	539	12	effective	effective	JJ
cord-015684-q10sx1dm	539	13	prophylactic	prophylactic	JJ
cord-015684-q10sx1dm	539	14	agent	agent	NN
cord-015684-q10sx1dm	539	15	in	in	IN
cord-015684-q10sx1dm	539	16	bipolar	bipolar	JJ
cord-015684-q10sx1dm	539	17	disorder	disorder	NN
cord-015684-q10sx1dm	539	18	.	.	.
cord-015684-q10sx1dm	540	1	Response	response	NN
cord-015684-q10sx1dm	540	2	to	to	IN
cord-015684-q10sx1dm	540	3	lithium	lithium	NN
cord-015684-q10sx1dm	540	4	treatment	treatment	NN
cord-015684-q10sx1dm	540	5	seems	seem	VBZ
cord-015684-q10sx1dm	540	6	to	to	TO
cord-015684-q10sx1dm	540	7	be	be	VB
cord-015684-q10sx1dm	540	8	,	,	,
cord-015684-q10sx1dm	540	9	at	at	IN
cord-015684-q10sx1dm	540	10	least	least	JJS
cord-015684-q10sx1dm	540	11	in	in	IN
cord-015684-q10sx1dm	540	12	part	part	NN
cord-015684-q10sx1dm	540	13	,	,	,
cord-015684-q10sx1dm	540	14	genetically	genetically	RB
cord-015684-q10sx1dm	540	15	determined	determined	JJ
cord-015684-q10sx1dm	540	16	.	.	.
cord-015684-q10sx1dm	541	1	It	-PRON-	PRP
cord-015684-q10sx1dm	541	2	has	have	VBZ
cord-015684-q10sx1dm	541	3	been	be	VBN
cord-015684-q10sx1dm	541	4	suggested	suggest	VBN
cord-015684-q10sx1dm	541	5	that	that	IN
cord-015684-q10sx1dm	541	6	lithium	lithium	NN
cord-015684-q10sx1dm	541	7	exerts	exert	VBZ
cord-015684-q10sx1dm	541	8	an	an	DT
cord-015684-q10sx1dm	541	9	effect	effect	NN
cord-015684-q10sx1dm	541	10	on	on	IN
cord-015684-q10sx1dm	541	11	signal	signal	NN
cord-015684-q10sx1dm	541	12	transduction	transduction	NN
cord-015684-q10sx1dm	541	13	pathways	pathway	NNS
cord-015684-q10sx1dm	541	14	,	,	,
cord-015684-q10sx1dm	541	15	such	such	JJ
cord-015684-q10sx1dm	541	16	as	as	IN
cord-015684-q10sx1dm	541	17	the	the	DT
cord-015684-q10sx1dm	541	18	cyclic	cyclic	JJ
cord-015684-q10sx1dm	541	19	adenosine	adenosine	NN
cord-015684-q10sx1dm	541	20	monophosphate	monophosphate	NN
cord-015684-q10sx1dm	541	21	(	(	-LRB-
cord-015684-q10sx1dm	541	22	cAMP	camp	NN
cord-015684-q10sx1dm	541	23	)	)	-RRB-
cord-015684-q10sx1dm	541	24	pathway	pathway	NN
cord-015684-q10sx1dm	541	25	.	.	.
cord-015684-q10sx1dm	542	1	Association	Association	NNP
cord-015684-q10sx1dm	542	2	studies	study	NNS
cord-015684-q10sx1dm	542	3	in	in	IN
cord-015684-q10sx1dm	542	4	patients	patient	NNS
cord-015684-q10sx1dm	542	5	with	with	IN
cord-015684-q10sx1dm	542	6	bipolar	bipolar	JJ
cord-015684-q10sx1dm	542	7	disorders	disorder	NNS
cord-015684-q10sx1dm	542	8	revealed	reveal	VBD
cord-015684-q10sx1dm	542	9	that	that	IN
cord-015684-q10sx1dm	542	10	CREB1	CREB1	NNP
cord-015684-q10sx1dm	542	11	-	-	HYPH
cord-015684-q10sx1dm	542	12	1H	1h	CD
cord-015684-q10sx1dm	542	13	SNP	SNP	NNP
cord-015684-q10sx1dm	542	14	(	(	-LRB-
cord-015684-q10sx1dm	542	15	G	G	NNP
cord-015684-q10sx1dm	542	16	/	/	,
cord-015684-q10sx1dm	542	17	A	a	DT
cord-015684-q10sx1dm	542	18	change	change	NN
cord-015684-q10sx1dm	542	19	at	at	IN
cord-015684-q10sx1dm	542	20	2q32.3-q34	2q32.3-q34	CD
cord-015684-q10sx1dm	542	21	)	)	-RRB-
cord-015684-q10sx1dm	542	22	and	and	CC
cord-015684-q10sx1dm	542	23	CREB1	CREB1	NNP
cord-015684-q10sx1dm	542	24	-	-	HYPH
cord-015684-q10sx1dm	542	25	7H	7H	NNP
cord-015684-q10sx1dm	542	26	(	(	-LRB-
cord-015684-q10sx1dm	542	27	T	T	NNP
cord-015684-q10sx1dm	542	28	/	/	SYM
cord-015684-q10sx1dm	542	29	C	C	NNP
cord-015684-q10sx1dm	542	30	change	change	NN
cord-015684-q10sx1dm	542	31	)	)	-RRB-
cord-015684-q10sx1dm	542	32	may	may	MD
cord-015684-q10sx1dm	542	33	be	be	VB
cord-015684-q10sx1dm	542	34	associated	associate	VBN
cord-015684-q10sx1dm	542	35	with	with	IN
cord-015684-q10sx1dm	542	36	bipolar	bipolar	JJ
cord-015684-q10sx1dm	542	37	disorder	disorder	NN
cord-015684-q10sx1dm	542	38	and	and	CC
cord-015684-q10sx1dm	542	39	lithium	lithium	NN
cord-015684-q10sx1dm	542	40	response	response	NN
cord-015684-q10sx1dm	542	41	.	.	.
cord-015684-q10sx1dm	543	1	163	163	CD
cord-015684-q10sx1dm	543	2	DNA	dna	NN
cord-015684-q10sx1dm	543	3	oligonucleotide	oligonucleotide	NN
cord-015684-q10sx1dm	543	4	microarrays	microarray	NNS
cord-015684-q10sx1dm	543	5	have	have	VBP
cord-015684-q10sx1dm	543	6	been	be	VBN
cord-015684-q10sx1dm	543	7	used	use	VBN
cord-015684-q10sx1dm	543	8	to	to	TO
cord-015684-q10sx1dm	543	9	evaluate	evaluate	VB
cord-015684-q10sx1dm	543	10	gene	gene	NN
cord-015684-q10sx1dm	543	11	expression	expression	NN
cord-015684-q10sx1dm	543	12	in	in	IN
cord-015684-q10sx1dm	543	13	the	the	DT
cord-015684-q10sx1dm	543	14	substantia	substantia	NN
cord-015684-q10sx1dm	543	15	nigra	nigra	NN
cord-015684-q10sx1dm	543	16	of	of	IN
cord-015684-q10sx1dm	543	17	patients	patient	NNS
cord-015684-q10sx1dm	543	18	with	with	IN
cord-015684-q10sx1dm	543	19	Parkinson	Parkinson	NNP
cord-015684-q10sx1dm	543	20	's	's	POS
cord-015684-q10sx1dm	543	21	disease	disease	NN
cord-015684-q10sx1dm	543	22	(	(	-LRB-
cord-015684-q10sx1dm	543	23	PD	PD	NNP
cord-015684-q10sx1dm	543	24	)	)	-RRB-
cord-015684-q10sx1dm	543	25	.	.	.
cord-015684-q10sx1dm	544	1	Sporadic	sporadic	JJ
cord-015684-q10sx1dm	544	2	PD	PD	NNP
cord-015684-q10sx1dm	544	3	is	be	VBZ
cord-015684-q10sx1dm	544	4	characterized	characterize	VBN
cord-015684-q10sx1dm	544	5	by	by	IN
cord-015684-q10sx1dm	544	6	progressive	progressive	JJ
cord-015684-q10sx1dm	544	7	death	death	NN
cord-015684-q10sx1dm	544	8	of	of	IN
cord-015684-q10sx1dm	544	9	dopaminergic	dopaminergic	JJ
cord-015684-q10sx1dm	544	10	neurons	neuron	NNS
cord-015684-q10sx1dm	544	11	within	within	IN
cord-015684-q10sx1dm	544	12	the	the	DT
cord-015684-q10sx1dm	544	13	substantia	substantia	NNP
cord-015684-q10sx1dm	544	14	nigra	nigra	NN
cord-015684-q10sx1dm	544	15	,	,	,
cord-015684-q10sx1dm	544	16	where	where	WRB
cord-015684-q10sx1dm	544	17	cell	cell	NN
cord-015684-q10sx1dm	544	18	death	death	NN
cord-015684-q10sx1dm	544	19	is	be	VBZ
cord-015684-q10sx1dm	544	20	not	not	RB
cord-015684-q10sx1dm	544	21	uniform	uniform	JJ
cord-015684-q10sx1dm	544	22	.	.	.
cord-015684-q10sx1dm	545	1	The	the	DT
cord-015684-q10sx1dm	545	2	lateral	lateral	JJ
cord-015684-q10sx1dm	545	3	tier	tier	NN
cord-015684-q10sx1dm	545	4	of	of	IN
cord-015684-q10sx1dm	545	5	the	the	DT
cord-015684-q10sx1dm	545	6	substantia	substantia	NNP
cord-015684-q10sx1dm	545	7	nigra	nigra	NNP
cord-015684-q10sx1dm	545	8	(	(	-LRB-
cord-015684-q10sx1dm	545	9	SNL	SNL	NNP
cord-015684-q10sx1dm	545	10	)	)	-RRB-
cord-015684-q10sx1dm	545	11	degenerates	degenerate	VBZ
cord-015684-q10sx1dm	545	12	earlier	early	RBR
cord-015684-q10sx1dm	545	13	and	and	CC
cord-015684-q10sx1dm	545	14	more	more	RBR
cord-015684-q10sx1dm	545	15	severely	severely	RB
cord-015684-q10sx1dm	545	16	than	than	IN
cord-015684-q10sx1dm	545	17	the	the	DT
cord-015684-q10sx1dm	545	18	more	more	RBR
cord-015684-q10sx1dm	545	19	medial	medial	JJ
cord-015684-q10sx1dm	545	20	nigral	nigral	JJ
cord-015684-q10sx1dm	545	21	component	component	NN
cord-015684-q10sx1dm	545	22	(	(	-LRB-
cord-015684-q10sx1dm	545	23	SNM	SNM	NNP
cord-015684-q10sx1dm	545	24	)	)	-RRB-
cord-015684-q10sx1dm	545	25	.	.	.
cord-015684-q10sx1dm	546	1	Genes	gene	NNS
cord-015684-q10sx1dm	546	2	expressed	express	VBD
cord-015684-q10sx1dm	546	3	more	more	RBR
cord-015684-q10sx1dm	546	4	highly	highly	RB
cord-015684-q10sx1dm	546	5	in	in	IN
cord-015684-q10sx1dm	546	6	the	the	DT
cord-015684-q10sx1dm	546	7	PD	PD	NNP
cord-015684-q10sx1dm	546	8	SNL	SNL	NNP
cord-015684-q10sx1dm	546	9	included	include	VBD
cord-015684-q10sx1dm	546	10	the	the	DT
cord-015684-q10sx1dm	546	11	cell	cell	NN
cord-015684-q10sx1dm	546	12	death	death	NN
cord-015684-q10sx1dm	546	13	gene	gene	NN
cord-015684-q10sx1dm	546	14	,	,	,
cord-015684-q10sx1dm	546	15	p53	p53	NN
cord-015684-q10sx1dm	546	16	effector	effector	NN
cord-015684-q10sx1dm	546	17	related	relate	VBN
cord-015684-q10sx1dm	546	18	to	to	IN
cord-015684-q10sx1dm	546	19	PMP22	PMP22	NNP
cord-015684-q10sx1dm	546	20	,	,	,
cord-015684-q10sx1dm	546	21	the	the	DT
cord-015684-q10sx1dm	546	22	TNFR	TNFR	NNP
cord-015684-q10sx1dm	546	23	gene	gene	NN
cord-015684-q10sx1dm	546	24	,	,	,
cord-015684-q10sx1dm	546	25	TNFR	TNFR	NNP
cord-015684-q10sx1dm	546	26	superfamily	superfamily	NN
cord-015684-q10sx1dm	546	27	,	,	,
cord-015684-q10sx1dm	546	28	member	member	NN
cord-015684-q10sx1dm	546	29	21	21	CD
cord-015684-q10sx1dm	546	30	,	,	,
cord-015684-q10sx1dm	546	31	and	and	CC
cord-015684-q10sx1dm	546	32	the	the	DT
cord-015684-q10sx1dm	546	33	mitochondrial	mitochondrial	JJ
cord-015684-q10sx1dm	546	34	complex	complex	NN
cord-015684-q10sx1dm	547	1	I	-PRON-	PRP
cord-015684-q10sx1dm	547	2	gene	gene	NN
cord-015684-q10sx1dm	547	3	,	,	,
cord-015684-q10sx1dm	547	4	NADH	NADH	NNP
cord-015684-q10sx1dm	547	5	dehydrogenase	dehydrogenase	NN
cord-015684-q10sx1dm	547	6	(	(	-LRB-
cord-015684-q10sx1dm	547	7	ubiquinone	ubiquinone	NN
cord-015684-q10sx1dm	547	8	)	)	-RRB-
cord-015684-q10sx1dm	548	1	1-beta	1-beta	CD
cord-015684-q10sx1dm	549	1	subcomplex	subcomplex	NNP
cord-015684-q10sx1dm	549	2	,	,	,
cord-015684-q10sx1dm	549	3	3	3	CD
cord-015684-q10sx1dm	549	4	,	,	,
cord-015684-q10sx1dm	549	5	12	12	CD
cord-015684-q10sx1dm	549	6	kDa	kDa	NNS
cord-015684-q10sx1dm	549	7	(	(	-LRB-
cord-015684-q10sx1dm	549	8	NDUFβ3	NDUFβ3	NNP
cord-015684-q10sx1dm	549	9	)	)	-RRB-
cord-015684-q10sx1dm	549	10	.	.	.
cord-015684-q10sx1dm	550	1	Genes	gene	NNS
cord-015684-q10sx1dm	550	2	that	that	WDT
cord-015684-q10sx1dm	550	3	were	be	VBD
cord-015684-q10sx1dm	550	4	more	more	RBR
cord-015684-q10sx1dm	550	5	highly	highly	RB
cord-015684-q10sx1dm	550	6	expressed	express	VBN
cord-015684-q10sx1dm	550	7	in	in	IN
cord-015684-q10sx1dm	550	8	PD	PD	NNP
cord-015684-q10sx1dm	550	9	SNM	SNM	NNP
cord-015684-q10sx1dm	550	10	included	include	VBD
cord-015684-q10sx1dm	550	11	the	the	DT
cord-015684-q10sx1dm	550	12	dopamine	dopamine	NN
cord-015684-q10sx1dm	550	13	cell	cell	NN
cord-015684-q10sx1dm	550	14	signaling	signaling	NN
cord-015684-q10sx1dm	550	15	gene	gene	NN
cord-015684-q10sx1dm	550	16	,	,	,
cord-015684-q10sx1dm	550	17	cyclic	cyclic	JJ
cord-015684-q10sx1dm	550	18	adenosine	adenosine	NN
cord-015684-q10sx1dm	550	19	monophosphate	monophosphate	NN
cord-015684-q10sx1dm	550	20	-	-	HYPH
cord-015684-q10sx1dm	550	21	regulated	regulate	VBN
cord-015684-q10sx1dm	550	22	phosphoprotein	phosphoprotein	NN
cord-015684-q10sx1dm	550	23	,	,	,
cord-015684-q10sx1dm	550	24	21	21	CD
cord-015684-q10sx1dm	550	25	kDa	kDa	NNS
cord-015684-q10sx1dm	550	26	,	,	,
cord-015684-q10sx1dm	550	27	the	the	DT
cord-015684-q10sx1dm	550	28	activated	activate	VBN
cord-015684-q10sx1dm	550	29	macrophage	macrophage	NN
cord-015684-q10sx1dm	550	30	gene	gene	NN
cord-015684-q10sx1dm	550	31	,	,	,
cord-015684-q10sx1dm	550	32	stabilin	stabilin	NNP
cord-015684-q10sx1dm	550	33	1	1	CD
cord-015684-q10sx1dm	550	34	,	,	,
cord-015684-q10sx1dm	550	35	and	and	CC
cord-015684-q10sx1dm	550	36	two	two	CD
cord-015684-q10sx1dm	550	37	glutathione	glutathione	NN
cord-015684-q10sx1dm	550	38	peroxidase	peroxidase	NN
cord-015684-q10sx1dm	550	39	(	(	-LRB-
cord-015684-q10sx1dm	550	40	GPX	GPX	NNP
cord-015684-q10sx1dm	550	41	)	)	-RRB-
cord-015684-q10sx1dm	550	42	genes	gene	NNS
cord-015684-q10sx1dm	550	43	,	,	,
cord-015684-q10sx1dm	550	44	GPX1	GPX1	NNP
cord-015684-q10sx1dm	550	45	and	and	CC
cord-015684-q10sx1dm	550	46	GPX3	GPX3	NNP
cord-015684-q10sx1dm	550	47	.	.	.
cord-015684-q10sx1dm	551	1	This	this	DT
cord-015684-q10sx1dm	551	2	gene	gene	NN
cord-015684-q10sx1dm	551	3	expression	expression	NN
cord-015684-q10sx1dm	551	4	profi	profi	NNP
cord-015684-q10sx1dm	551	5	le	le	NNP
cord-015684-q10sx1dm	551	6	reveals	reveal	VBZ
cord-015684-q10sx1dm	551	7	that	that	IN
cord-015684-q10sx1dm	551	8	there	there	EX
cord-015684-q10sx1dm	551	9	is	be	VBZ
cord-015684-q10sx1dm	551	10	increased	increase	VBN
cord-015684-q10sx1dm	551	11	expression	expression	NN
cord-015684-q10sx1dm	551	12	of	of	IN
cord-015684-q10sx1dm	551	13	genes	gene	NNS
cord-015684-q10sx1dm	551	14	encoding	encode	VBG
cord-015684-q10sx1dm	551	15	pro	pro	JJ
cord-015684-q10sx1dm	551	16	-	-	JJ
cord-015684-q10sx1dm	551	17	infl	infl	JJ
cord-015684-q10sx1dm	551	18	ammatory	ammatory	NN
cord-015684-q10sx1dm	551	19	cytokines	cytokine	NNS
cord-015684-q10sx1dm	551	20	and	and	CC
cord-015684-q10sx1dm	551	21	subunits	subunit	NNS
cord-015684-q10sx1dm	551	22	of	of	IN
cord-015684-q10sx1dm	551	23	the	the	DT
cord-015684-q10sx1dm	551	24	mitochondrial	mitochondrial	JJ
cord-015684-q10sx1dm	551	25	electron	electron	NN
cord-015684-q10sx1dm	551	26	transport	transport	NN
cord-015684-q10sx1dm	551	27	chain	chain	NN
cord-015684-q10sx1dm	551	28	in	in	IN
cord-015684-q10sx1dm	551	29	glial	glial	JJ
cord-015684-q10sx1dm	551	30	cells	cell	NNS
cord-015684-q10sx1dm	551	31	,	,	,
cord-015684-q10sx1dm	551	32	and	and	CC
cord-015684-q10sx1dm	551	33	that	that	IN
cord-015684-q10sx1dm	551	34	there	there	EX
cord-015684-q10sx1dm	551	35	is	be	VBZ
cord-015684-q10sx1dm	551	36	a	a	DT
cord-015684-q10sx1dm	551	37	decreased	decreased	JJ
cord-015684-q10sx1dm	551	38	expression	expression	NN
cord-015684-q10sx1dm	551	39	of	of	IN
cord-015684-q10sx1dm	551	40	several	several	JJ
cord-015684-q10sx1dm	551	41	glutathione	glutathione	NN
cord-015684-q10sx1dm	551	42	-	-	HYPH
cord-015684-q10sx1dm	551	43	related	relate	VBN
cord-015684-q10sx1dm	551	44	genes	gene	NNS
cord-015684-q10sx1dm	551	45	in	in	IN
cord-015684-q10sx1dm	551	46	the	the	DT
cord-015684-q10sx1dm	551	47	GNL	GNL	NNP
cord-015684-q10sx1dm	551	48	,	,	,
cord-015684-q10sx1dm	551	49	suggesting	suggest	VBG
cord-015684-q10sx1dm	551	50	a	a	DT
cord-015684-q10sx1dm	551	51	molecular	molecular	JJ
cord-015684-q10sx1dm	551	52	basis	basis	NN
cord-015684-q10sx1dm	551	53	for	for	IN
cord-015684-q10sx1dm	551	54	pathoclisis	pathoclisis	NN
cord-015684-q10sx1dm	551	55	.	.	.
cord-015684-q10sx1dm	552	1	164	164	CD
cord-015684-q10sx1dm	553	1	These	these	DT
cord-015684-q10sx1dm	553	2	fi	fi	NN
cord-015684-q10sx1dm	553	3	ndings	nding	NNS
cord-015684-q10sx1dm	553	4	may	may	MD
cord-015684-q10sx1dm	553	5	contribute	contribute	VB
cord-015684-q10sx1dm	553	6	to	to	TO
cord-015684-q10sx1dm	553	7	open	open	VB
cord-015684-q10sx1dm	553	8	new	new	JJ
cord-015684-q10sx1dm	553	9	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	553	10	avenues	avenue	NNS
cord-015684-q10sx1dm	553	11	in	in	IN
cord-015684-q10sx1dm	553	12	PD	PD	NNP
cord-015684-q10sx1dm	553	13	,	,	,
cord-015684-q10sx1dm	553	14	where	where	WRB
cord-015684-q10sx1dm	553	15	glial	glial	JJ
cord-015684-q10sx1dm	553	16	cells	cell	NNS
cord-015684-q10sx1dm	553	17	might	may	MD
cord-015684-q10sx1dm	553	18	represent	represent	VB
cord-015684-q10sx1dm	553	19	potential	potential	JJ
cord-015684-q10sx1dm	553	20	targets	target	NNS
cord-015684-q10sx1dm	553	21	to	to	TO
cord-015684-q10sx1dm	553	22	halt	halt	VB
cord-015684-q10sx1dm	553	23	disease	disease	NN
cord-015684-q10sx1dm	553	24	progression	progression	NN
cord-015684-q10sx1dm	553	25	.	.	.
cord-015684-q10sx1dm	554	1	Pharmacological	pharmacological	JJ
cord-015684-q10sx1dm	554	2	inhibition	inhibition	NN
cord-015684-q10sx1dm	554	3	of	of	IN
cord-015684-q10sx1dm	554	4	cyclic	cyclic	JJ
cord-015684-q10sx1dm	554	5	-	-	HYPH
cord-015684-q10sx1dm	554	6	dependent	dependent	JJ
cord-015684-q10sx1dm	554	7	kinase	kinase	NN
cord-015684-q10sx1dm	554	8	5	5	CD
cord-015684-q10sx1dm	554	9	(	(	-LRB-
cord-015684-q10sx1dm	554	10	CDK5	CDK5	NNP
cord-015684-q10sx1dm	554	11	)	)	-RRB-
cord-015684-q10sx1dm	554	12	protects	protect	VBZ
cord-015684-q10sx1dm	554	13	neurons	neuron	NNS
cord-015684-q10sx1dm	554	14	under	under	IN
cord-015684-q10sx1dm	554	15	distinct	distinct	JJ
cord-015684-q10sx1dm	554	16	stressful	stressful	JJ
cord-015684-q10sx1dm	554	17	conditions	condition	NNS
cord-015684-q10sx1dm	554	18	.	.	.
cord-015684-q10sx1dm	555	1	In	in	IN
cord-015684-q10sx1dm	555	2	AD	ad	NN
cord-015684-q10sx1dm	555	3	and	and	CC
cord-015684-q10sx1dm	555	4	amyotrophic	amyotrophic	JJ
cord-015684-q10sx1dm	555	5	lateral	lateral	JJ
cord-015684-q10sx1dm	555	6	sclerosis	sclerosis	NN
cord-015684-q10sx1dm	555	7	deregulation	deregulation	NN
cord-015684-q10sx1dm	555	8	of	of	IN
cord-015684-q10sx1dm	555	9	CDK5	CDK5	NNP
cord-015684-q10sx1dm	555	10	causes	cause	VBZ
cord-015684-q10sx1dm	555	11	hyperphosphorylation	hyperphosphorylation	NN
cord-015684-q10sx1dm	555	12	of	of	IN
cord-015684-q10sx1dm	555	13	tau	tau	NNP
cord-015684-q10sx1dm	555	14	and	and	CC
cord-015684-q10sx1dm	555	15	neurofi	neurofi	NNP
cord-015684-q10sx1dm	555	16	lament	lament	NN
cord-015684-q10sx1dm	555	17	proteins	protein	NNS
cord-015684-q10sx1dm	555	18	,	,	,
cord-015684-q10sx1dm	555	19	respectively	respectively	RB
cord-015684-q10sx1dm	555	20	,	,	,
cord-015684-q10sx1dm	555	21	leading	lead	VBG
cord-015684-q10sx1dm	555	22	to	to	IN
cord-015684-q10sx1dm	555	23	neuronal	neuronal	JJ
cord-015684-q10sx1dm	555	24	cell	cell	NN
cord-015684-q10sx1dm	555	25	death	death	NN
cord-015684-q10sx1dm	555	26	.	.	.
cord-015684-q10sx1dm	556	1	By	by	IN
cord-015684-q10sx1dm	556	2	two	two	CD
cord-015684-q10sx1dm	556	3	-	-	HYPH
cord-015684-q10sx1dm	556	4	dimensional	dimensional	JJ
cord-015684-q10sx1dm	556	5	gel	gel	NN
cord-015684-q10sx1dm	556	6	electrophoresis	electrophoresis	NN
cord-015684-q10sx1dm	556	7	and	and	CC
cord-015684-q10sx1dm	556	8	matrix	matrix	NN
cord-015684-q10sx1dm	556	9	assisted	assist	VBN
cord-015684-q10sx1dm	556	10	laser	laser	NN
cord-015684-q10sx1dm	556	11	desorption	desorption	NN
cord-015684-q10sx1dm	556	12	/	/	SYM
cord-015684-q10sx1dm	556	13	ionisation	ionisation	NN
cord-015684-q10sx1dm	556	14	-	-	HYPH
cord-015684-q10sx1dm	556	15	time	time	NN
cord-015684-q10sx1dm	556	16	of	of	IN
cord-015684-q10sx1dm	556	17	fl	fl	NNP
cord-015684-q10sx1dm	556	18	ight	ight	NNP
cord-015684-q10sx1dm	556	19	(	(	-LRB-
cord-015684-q10sx1dm	556	20	MALDI	MALDI	NNP
cord-015684-q10sx1dm	556	21	-	-	HYPH
cord-015684-q10sx1dm	556	22	TOF)-mass	TOF)-mass	NNP
cord-015684-q10sx1dm	556	23	spectrometry	spectrometry	NN
cord-015684-q10sx1dm	556	24	,	,	,
cord-015684-q10sx1dm	556	25	several	several	JJ
cord-015684-q10sx1dm	556	26	phosphoproteins	phosphoprotein	NNS
cord-015684-q10sx1dm	556	27	that	that	WDT
cord-015684-q10sx1dm	556	28	are	be	VBP
cord-015684-q10sx1dm	556	29	modulated	modulate	VBN
cord-015684-q10sx1dm	556	30	by	by	IN
cord-015684-q10sx1dm	556	31	CDK5	CDK5	NNP
cord-015684-q10sx1dm	556	32	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	556	33	have	have	VBP
cord-015684-q10sx1dm	556	34	been	be	VBN
cord-015684-q10sx1dm	556	35	identifi	identifi	VBN
cord-015684-q10sx1dm	556	36	ed	ed	NNP
cord-015684-q10sx1dm	556	37	.	.	.
cord-015684-q10sx1dm	557	1	These	these	DT
cord-015684-q10sx1dm	557	2	phosphoproteins	phosphoprotein	NNS
cord-015684-q10sx1dm	557	3	include	include	VBP
cord-015684-q10sx1dm	557	4	syndapin	syndapin	NNP
cord-015684-q10sx1dm	557	5	I	-PRON-	PRP
cord-015684-q10sx1dm	557	6	which	which	WDT
cord-015684-q10sx1dm	557	7	is	be	VBZ
cord-015684-q10sx1dm	557	8	involved	involve	VBN
cord-015684-q10sx1dm	557	9	in	in	IN
cord-015684-q10sx1dm	557	10	vesicle	vesicle	NN
cord-015684-q10sx1dm	557	11	recycling	recycling	NN
cord-015684-q10sx1dm	557	12	,	,	,
cord-015684-q10sx1dm	557	13	and	and	CC
cord-015684-q10sx1dm	557	14	dynein	dynein	JJ
cord-015684-q10sx1dm	557	15	light	light	JJ
cord-015684-q10sx1dm	557	16	intermediate	intermediate	JJ
cord-015684-q10sx1dm	557	17	chain	chain	NN
cord-015684-q10sx1dm	557	18	2	2	CD
cord-015684-q10sx1dm	557	19	which	which	WDT
cord-015684-q10sx1dm	557	20	represents	represent	VBZ
cord-015684-q10sx1dm	557	21	a	a	DT
cord-015684-q10sx1dm	557	22	regulatory	regulatory	JJ
cord-015684-q10sx1dm	557	23	subunit	subunit	NN
cord-015684-q10sx1dm	557	24	of	of	IN
cord-015684-q10sx1dm	557	25	the	the	DT
cord-015684-q10sx1dm	557	26	dynein	dynein	NNP
cord-015684-q10sx1dm	557	27	protein	protein	NN
cord-015684-q10sx1dm	557	28	complex	complex	NN
cord-015684-q10sx1dm	557	29	,	,	,
cord-015684-q10sx1dm	557	30	confi	confi	NNP
cord-015684-q10sx1dm	557	31	rming	rme	VBG
cord-015684-q10sx1dm	557	32	the	the	DT
cord-015684-q10sx1dm	557	33	role	role	NN
cord-015684-q10sx1dm	557	34	of	of	IN
cord-015684-q10sx1dm	557	35	CDK5	CDK5	NNP
cord-015684-q10sx1dm	557	36	in	in	IN
cord-015684-q10sx1dm	557	37	synaptic	synaptic	JJ
cord-015684-q10sx1dm	557	38	signaling	signaling	NN
cord-015684-q10sx1dm	557	39	and	and	CC
cord-015684-q10sx1dm	557	40	axonal	axonal	JJ
cord-015684-q10sx1dm	557	41	transport	transport	NN
cord-015684-q10sx1dm	557	42	.	.	.
cord-015684-q10sx1dm	558	1	Other	other	JJ
cord-015684-q10sx1dm	558	2	phosphoproteins	phosphoprotein	NNS
cord-015684-q10sx1dm	558	3	detected	detect	VBN
cord-015684-q10sx1dm	558	4	are	be	VBP
cord-015684-q10sx1dm	558	5	cofi	cofi	NNP
cord-015684-q10sx1dm	558	6	lin	lin	NNP
cord-015684-q10sx1dm	558	7	and	and	CC
cord-015684-q10sx1dm	558	8	collapsing	collapse	VBG
cord-015684-q10sx1dm	558	9	response	response	NN
cord-015684-q10sx1dm	558	10	mediator	mediator	NN
cord-015684-q10sx1dm	558	11	protein	protein	NN
cord-015684-q10sx1dm	558	12	,	,	,
cord-015684-q10sx1dm	558	13	involved	involve	VBN
cord-015684-q10sx1dm	558	14	in	in	IN
cord-015684-q10sx1dm	558	15	neuronal	neuronal	JJ
cord-015684-q10sx1dm	558	16	survival	survival	NN
cord-015684-q10sx1dm	559	1	and/or	and/or	CC
cord-015684-q10sx1dm	559	2	neurite	neurite	NN
cord-015684-q10sx1dm	559	3	outgrowth	outgrowth	NN
cord-015684-q10sx1dm	559	4	.	.	.
cord-015684-q10sx1dm	560	1	Selective	selective	JJ
cord-015684-q10sx1dm	560	2	CDK5	CDK5	NNP
cord-015684-q10sx1dm	560	3	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	560	4	can	can	MD
cord-015684-q10sx1dm	560	5	also	also	RB
cord-015684-q10sx1dm	560	6	block	block	VB
cord-015684-q10sx1dm	560	7	mitochondrial	mitochondrial	JJ
cord-015684-q10sx1dm	560	8	translocation	translocation	NN
cord-015684-q10sx1dm	560	9	of	of	IN
cord-015684-q10sx1dm	560	10	pro	pro	JJ
cord-015684-q10sx1dm	560	11	-	-	JJ
cord-015684-q10sx1dm	560	12	apoptotic	apoptotic	JJ
cord-015684-q10sx1dm	560	13	cofi	cofi	NNP
cord-015684-q10sx1dm	560	14	lin	lin	NNP
cord-015684-q10sx1dm	560	15	.	.	.
cord-015684-q10sx1dm	561	1	Phosphoproteome	Phosphoproteome	NNP
cord-015684-q10sx1dm	561	2	and	and	CC
cord-015684-q10sx1dm	561	3	transcriptome	transcriptome	NN
cord-015684-q10sx1dm	561	4	analysis	analysis	NN
cord-015684-q10sx1dm	561	5	of	of	IN
cord-015684-q10sx1dm	561	6	neurons	neuron	NNS
cord-015684-q10sx1dm	561	7	indicate	indicate	VBP
cord-015684-q10sx1dm	561	8	that	that	IN
cord-015684-q10sx1dm	561	9	CDK5	CDK5	NNP
cord-015684-q10sx1dm	561	10	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	561	11	promote	promote	VBP
cord-015684-q10sx1dm	561	12	both	both	DT
cord-015684-q10sx1dm	561	13	neuronal	neuronal	JJ
cord-015684-q10sx1dm	561	14	survival	survival	NN
cord-015684-q10sx1dm	561	15	and	and	CC
cord-015684-q10sx1dm	561	16	neurite	neurite	NN
cord-015684-q10sx1dm	561	17	outgrowth	outgrowth	NN
cord-015684-q10sx1dm	561	18	.	.	.
cord-015684-q10sx1dm	562	1	165	165	CD
cord-015684-q10sx1dm	563	1	These	these	DT
cord-015684-q10sx1dm	563	2	compounds	compound	NNS
cord-015684-q10sx1dm	563	3	might	may	MD
cord-015684-q10sx1dm	563	4	represent	represent	VB
cord-015684-q10sx1dm	563	5	novel	novel	JJ
cord-015684-q10sx1dm	563	6	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	563	7	alternatives	alternative	NNS
cord-015684-q10sx1dm	563	8	in	in	IN
cord-015684-q10sx1dm	563	9	neurodegenerative	neurodegenerative	JJ
cord-015684-q10sx1dm	563	10	disorders	disorder	NNS
cord-015684-q10sx1dm	563	11	.	.	.
cord-015684-q10sx1dm	564	1	Despite	despite	IN
cord-015684-q10sx1dm	564	2	the	the	DT
cord-015684-q10sx1dm	564	3	promising	promising	JJ
cord-015684-q10sx1dm	564	4	results	result	NNS
cord-015684-q10sx1dm	564	5	obtained	obtain	VBN
cord-015684-q10sx1dm	564	6	with	with	IN
cord-015684-q10sx1dm	564	7	structural	structural	JJ
cord-015684-q10sx1dm	564	8	and	and	CC
cord-015684-q10sx1dm	564	9	functional	functional	JJ
cord-015684-q10sx1dm	564	10	genomic	genomic	JJ
cord-015684-q10sx1dm	564	11	procedures	procedure	NNS
cord-015684-q10sx1dm	564	12	to	to	TO
cord-015684-q10sx1dm	564	13	identify	identify	VB
cord-015684-q10sx1dm	564	14	associations	association	NNS
cord-015684-q10sx1dm	564	15	with	with	IN
cord-015684-q10sx1dm	564	16	disease	disease	NN
cord-015684-q10sx1dm	564	17	pathogenesis	pathogenesis	NN
cord-015684-q10sx1dm	564	18	and	and	CC
cord-015684-q10sx1dm	564	19	potential	potential	JJ
cord-015684-q10sx1dm	564	20	drug	drug	NN
cord-015684-q10sx1dm	564	21	targets	target	NNS
cord-015684-q10sx1dm	564	22	in	in	IN
cord-015684-q10sx1dm	564	23	CNS	CNS	NNP
cord-015684-q10sx1dm	564	24	disorders	disorder	NNS
cord-015684-q10sx1dm	564	25	,	,	,
cord-015684-q10sx1dm	564	26	it	-PRON-	PRP
cord-015684-q10sx1dm	564	27	must	must	MD
cord-015684-q10sx1dm	564	28	be	be	VB
cord-015684-q10sx1dm	564	29	kept	keep	VBN
cord-015684-q10sx1dm	564	30	in	in	IN
cord-015684-q10sx1dm	564	31	mind	mind	NN
cord-015684-q10sx1dm	564	32	that	that	IN
cord-015684-q10sx1dm	564	33	allelic	allelic	JJ
cord-015684-q10sx1dm	564	34	mRNA	mRNA	NNP
cord-015684-q10sx1dm	564	35	expression	expression	NN
cord-015684-q10sx1dm	564	36	is	be	VBZ
cord-015684-q10sx1dm	564	37	affected	affect	VBN
cord-015684-q10sx1dm	564	38	by	by	IN
cord-015684-q10sx1dm	564	39	genetic	genetic	JJ
cord-015684-q10sx1dm	564	40	and	and	CC
cord-015684-q10sx1dm	564	41	epigenetic	epigenetic	JJ
cord-015684-q10sx1dm	564	42	events	event	NNS
cord-015684-q10sx1dm	564	43	,	,	,
cord-015684-q10sx1dm	564	44	both	both	CC
cord-015684-q10sx1dm	564	45	with	with	IN
cord-015684-q10sx1dm	564	46	the	the	DT
cord-015684-q10sx1dm	564	47	potential	potential	NN
cord-015684-q10sx1dm	564	48	to	to	TO
cord-015684-q10sx1dm	564	49	modulate	modulate	VB
cord-015684-q10sx1dm	564	50	neurotransmitter	neurotransmitter	NN
cord-015684-q10sx1dm	564	51	tone	tone	NN
cord-015684-q10sx1dm	564	52	in	in	IN
cord-015684-q10sx1dm	564	53	the	the	DT
cord-015684-q10sx1dm	564	54	CNS	CNS	NNP
cord-015684-q10sx1dm	564	55	.	.	.
cord-015684-q10sx1dm	565	1	166	166	CD
cord-015684-q10sx1dm	565	2	Epigenetics	Epigenetics	NNP
cord-015684-q10sx1dm	565	3	is	be	VBZ
cord-015684-q10sx1dm	565	4	the	the	DT
cord-015684-q10sx1dm	565	5	study	study	NN
cord-015684-q10sx1dm	565	6	of	of	IN
cord-015684-q10sx1dm	565	7	how	how	WRB
cord-015684-q10sx1dm	565	8	the	the	DT
cord-015684-q10sx1dm	565	9	environment	environment	NN
cord-015684-q10sx1dm	565	10	can	can	MD
cord-015684-q10sx1dm	565	11	affect	affect	VB
cord-015684-q10sx1dm	565	12	the	the	DT
cord-015684-q10sx1dm	565	13	genome	genome	NN
cord-015684-q10sx1dm	565	14	of	of	IN
cord-015684-q10sx1dm	565	15	the	the	DT
cord-015684-q10sx1dm	565	16	individual	individual	NN
cord-015684-q10sx1dm	565	17	during	during	IN
cord-015684-q10sx1dm	565	18	its	-PRON-	PRP$
cord-015684-q10sx1dm	565	19	development	development	NN
cord-015684-q10sx1dm	565	20	as	as	RB
cord-015684-q10sx1dm	565	21	well	well	RB
cord-015684-q10sx1dm	565	22	as	as	IN
cord-015684-q10sx1dm	565	23	the	the	DT
cord-015684-q10sx1dm	565	24	development	development	NN
cord-015684-q10sx1dm	565	25	of	of	IN
cord-015684-q10sx1dm	565	26	its	-PRON-	PRP$
cord-015684-q10sx1dm	565	27	descendants	descendant	NNS
cord-015684-q10sx1dm	565	28	,	,	,
cord-015684-q10sx1dm	565	29	all	all	RB
cord-015684-q10sx1dm	565	30	without	without	IN
cord-015684-q10sx1dm	565	31	changing	change	VBG
cord-015684-q10sx1dm	565	32	the	the	DT
cord-015684-q10sx1dm	565	33	DNA	dna	NN
cord-015684-q10sx1dm	565	34	sequence	sequence	NN
cord-015684-q10sx1dm	565	35	,	,	,
cord-015684-q10sx1dm	565	36	but	but	CC
cord-015684-q10sx1dm	565	37	inducing	induce	VBG
cord-015684-q10sx1dm	565	38	modifi	modifi	JJ
cord-015684-q10sx1dm	565	39	cations	cation	NNS
cord-015684-q10sx1dm	565	40	in	in	IN
cord-015684-q10sx1dm	565	41	gene	gene	NN
cord-015684-q10sx1dm	565	42	expression	expression	NN
cord-015684-q10sx1dm	565	43	through	through	IN
cord-015684-q10sx1dm	565	44	DNA	dna	NN
cord-015684-q10sx1dm	565	45	methylation	methylation	NN
cord-015684-q10sx1dm	565	46	-	-	HYPH
cord-015684-q10sx1dm	565	47	demethylation	demethylation	NN
cord-015684-q10sx1dm	565	48	or	or	CC
cord-015684-q10sx1dm	565	49	through	through	IN
cord-015684-q10sx1dm	565	50	modifi	modifi	JJ
cord-015684-q10sx1dm	565	51	cation	cation	NN
cord-015684-q10sx1dm	565	52	of	of	IN
cord-015684-q10sx1dm	565	53	histones	histone	NNS
cord-015684-q10sx1dm	565	54	by	by	IN
cord-015684-q10sx1dm	565	55	processes	process	NNS
cord-015684-q10sx1dm	565	56	of	of	IN
cord-015684-q10sx1dm	565	57	methylation	methylation	NN
cord-015684-q10sx1dm	565	58	,	,	,
cord-015684-q10sx1dm	565	59	deacetylation	deacetylation	NN
cord-015684-q10sx1dm	565	60	,	,	,
cord-015684-q10sx1dm	565	61	and	and	CC
cord-015684-q10sx1dm	565	62	phosphorylation	phosphorylation	NN
cord-015684-q10sx1dm	565	63	.	.	.
cord-015684-q10sx1dm	566	1	167	167	CD
cord-015684-q10sx1dm	566	2	Cumulative	cumulative	JJ
cord-015684-q10sx1dm	566	3	experiences	experience	NNS
cord-015684-q10sx1dm	566	4	throughout	throughout	IN
cord-015684-q10sx1dm	566	5	life	life	NN
cord-015684-q10sx1dm	566	6	history	history	NN
cord-015684-q10sx1dm	566	7	interact	interact	VBP
cord-015684-q10sx1dm	566	8	with	with	IN
cord-015684-q10sx1dm	566	9	genetic	genetic	JJ
cord-015684-q10sx1dm	566	10	predispositions	predisposition	NNS
cord-015684-q10sx1dm	566	11	to	to	TO
cord-015684-q10sx1dm	566	12	shape	shape	VB
cord-015684-q10sx1dm	566	13	the	the	DT
cord-015684-q10sx1dm	566	14	individual	individual	NN
cord-015684-q10sx1dm	566	15	's	's	POS
cord-015684-q10sx1dm	566	16	behaviour	behaviour	NN
cord-015684-q10sx1dm	566	17	.	.	.
cord-015684-q10sx1dm	567	1	167	167	CD
cord-015684-q10sx1dm	567	2	Epigenetic	epigenetic	JJ
cord-015684-q10sx1dm	567	3	phenomena	phenomenon	NNS
cord-015684-q10sx1dm	567	4	can	can	MD
cord-015684-q10sx1dm	567	5	not	not	RB
cord-015684-q10sx1dm	567	6	be	be	VB
cord-015684-q10sx1dm	567	7	neglected	neglect	VBN
cord-015684-q10sx1dm	567	8	in	in	IN
cord-015684-q10sx1dm	567	9	the	the	DT
cord-015684-q10sx1dm	567	10	pathogenesis	pathogenesis	NN
cord-015684-q10sx1dm	567	11	and	and	CC
cord-015684-q10sx1dm	567	12	pharmacogenomics	pharmacogenomic	NNS
cord-015684-q10sx1dm	567	13	of	of	IN
cord-015684-q10sx1dm	567	14	CNS	CNS	NNP
cord-015684-q10sx1dm	567	15	disorders	disorder	NNS
cord-015684-q10sx1dm	567	16	.	.	.
cord-015684-q10sx1dm	568	1	Studies	study	NNS
cord-015684-q10sx1dm	568	2	in	in	IN
cord-015684-q10sx1dm	568	3	cancer	cancer	NN
cord-015684-q10sx1dm	568	4	research	research	NN
cord-015684-q10sx1dm	568	5	have	have	VBP
cord-015684-q10sx1dm	568	6	demonstrated	demonstrate	VBN
cord-015684-q10sx1dm	568	7	the	the	DT
cord-015684-q10sx1dm	568	8	antineoplastic	antineoplastic	JJ
cord-015684-q10sx1dm	568	9	effects	effect	NNS
cord-015684-q10sx1dm	568	10	of	of	IN
cord-015684-q10sx1dm	568	11	the	the	DT
cord-015684-q10sx1dm	568	12	DNA	dna	NN
cord-015684-q10sx1dm	568	13	methylation	methylation	NN
cord-015684-q10sx1dm	568	14	inhibitor	inhibitor	NN
cord-015684-q10sx1dm	568	15	hydralazine	hydralazine	NNP
cord-015684-q10sx1dm	568	16	and	and	CC
cord-015684-q10sx1dm	568	17	the	the	DT
cord-015684-q10sx1dm	568	18	histone	histone	NN
cord-015684-q10sx1dm	568	19	deacetylase	deacetylase	NN
cord-015684-q10sx1dm	568	20	inhibitor	inhibitor	NN
cord-015684-q10sx1dm	568	21	valproic	valproic	NN
cord-015684-q10sx1dm	568	22	acid	acid	NN
cord-015684-q10sx1dm	568	23	,	,	,
cord-015684-q10sx1dm	568	24	of	of	IN
cord-015684-q10sx1dm	568	25	current	current	JJ
cord-015684-q10sx1dm	568	26	use	use	NN
cord-015684-q10sx1dm	568	27	in	in	IN
cord-015684-q10sx1dm	568	28	epilepsy	epilepsy	NN
cord-015684-q10sx1dm	568	29	.	.	.
cord-015684-q10sx1dm	569	1	168	168	CD
cord-015684-q10sx1dm	569	2	Novel	novel	JJ
cord-015684-q10sx1dm	569	3	effects	effect	NNS
cord-015684-q10sx1dm	569	4	of	of	IN
cord-015684-q10sx1dm	569	5	some	some	DT
cord-015684-q10sx1dm	569	6	pleiotropic	pleiotropic	JJ
cord-015684-q10sx1dm	569	7	drugs	drug	NNS
cord-015684-q10sx1dm	569	8	with	with	IN
cord-015684-q10sx1dm	569	9	activity	activity	NN
cord-015684-q10sx1dm	569	10	on	on	IN
cord-015684-q10sx1dm	569	11	the	the	DT
cord-015684-q10sx1dm	569	12	CNS	CNS	NNP
cord-015684-q10sx1dm	569	13	have	have	VBP
cord-015684-q10sx1dm	569	14	to	to	TO
cord-015684-q10sx1dm	569	15	be	be	VB
cord-015684-q10sx1dm	569	16	explored	explore	VBN
cord-015684-q10sx1dm	569	17	to	to	TO
cord-015684-q10sx1dm	569	18	understand	understand	VB
cord-015684-q10sx1dm	569	19	in	in	IN
cord-015684-q10sx1dm	569	20	full	full	JJ
cord-015684-q10sx1dm	569	21	their	-PRON-	PRP$
cord-015684-q10sx1dm	569	22	mechanisms	mechanism	NNS
cord-015684-q10sx1dm	569	23	of	of	IN
cord-015684-q10sx1dm	569	24	action	action	NN
cord-015684-q10sx1dm	569	25	and	and	CC
cord-015684-q10sx1dm	569	26	adjust	adjust	VB
cord-015684-q10sx1dm	569	27	their	-PRON-	PRP$
cord-015684-q10sx1dm	569	28	dosages	dosage	NNS
cord-015684-q10sx1dm	569	29	for	for	IN
cord-015684-q10sx1dm	569	30	new	new	JJ
cord-015684-q10sx1dm	569	31	indications	indication	NNS
cord-015684-q10sx1dm	569	32	.	.	.
cord-015684-q10sx1dm	570	1	Both	both	DT
cord-015684-q10sx1dm	570	2	hyper	hyper	JJ
cord-015684-q10sx1dm	570	3	-	-	HYPH
cord-015684-q10sx1dm	570	4	and	and	CC
cord-015684-q10sx1dm	570	5	hypo	hypo	JJ
cord-015684-q10sx1dm	570	6	-	-	HYPH
cord-015684-q10sx1dm	570	7	DNA	dna	NN
cord-015684-q10sx1dm	570	8	methylation	methylation	NN
cord-015684-q10sx1dm	570	9	changes	change	NNS
cord-015684-q10sx1dm	570	10	of	of	IN
cord-015684-q10sx1dm	570	11	the	the	DT
cord-015684-q10sx1dm	570	12	regulatory	regulatory	JJ
cord-015684-q10sx1dm	570	13	regions	region	NNS
cord-015684-q10sx1dm	570	14	play	play	VBP
cord-015684-q10sx1dm	570	15	critical	critical	JJ
cord-015684-q10sx1dm	570	16	roles	role	NNS
cord-015684-q10sx1dm	570	17	in	in	IN
cord-015684-q10sx1dm	570	18	defi	defi	NNP
cord-015684-q10sx1dm	570	19	ning	ning	NNP
cord-015684-q10sx1dm	570	20	the	the	DT
cord-015684-q10sx1dm	570	21	altered	altered	JJ
cord-015684-q10sx1dm	570	22	functionality	functionality	NN
cord-015684-q10sx1dm	570	23	of	of	IN
cord-015684-q10sx1dm	570	24	genes	gene	NNS
cord-015684-q10sx1dm	570	25	(	(	-LRB-
cord-015684-q10sx1dm	570	26	MB	MB	NNP
cord-015684-q10sx1dm	570	27	-	-	HYPH
cord-015684-q10sx1dm	570	28	COMT	COMT	NNP
cord-015684-q10sx1dm	570	29	,	,	,
cord-015684-q10sx1dm	570	30	MAOA	MAOA	NNP
cord-015684-q10sx1dm	570	31	,	,	,
cord-015684-q10sx1dm	570	32	DAT1	DAT1	NNP
cord-015684-q10sx1dm	570	33	,	,	,
cord-015684-q10sx1dm	570	34	TH	TH	NNP
cord-015684-q10sx1dm	570	35	,	,	,
cord-015684-q10sx1dm	570	36	DRD1	DRD1	NNP
cord-015684-q10sx1dm	570	37	,	,	,
cord-015684-q10sx1dm	570	38	DRD2	DRD2	NNP
cord-015684-q10sx1dm	570	39	,	,	,
cord-015684-q10sx1dm	570	40	RELN	RELN	NNP
cord-015684-q10sx1dm	570	41	,	,	,
cord-015684-q10sx1dm	570	42	BDNF	BDNF	NNP
cord-015684-q10sx1dm	570	43	)	)	-RRB-
cord-015684-q10sx1dm	570	44	in	in	IN
cord-015684-q10sx1dm	570	45	major	major	JJ
cord-015684-q10sx1dm	570	46	psychiatric	psychiatric	JJ
cord-015684-q10sx1dm	570	47	disorders	disorder	NNS
cord-015684-q10sx1dm	570	48	,	,	,
cord-015684-q10sx1dm	570	49	such	such	JJ
cord-015684-q10sx1dm	570	50	as	as	IN
cord-015684-q10sx1dm	570	51	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	570	52	and	and	CC
cord-015684-q10sx1dm	570	53	bipolar	bipolar	JJ
cord-015684-q10sx1dm	570	54	disorder	disorder	NN
cord-015684-q10sx1dm	570	55	.	.	.
cord-015684-q10sx1dm	571	1	169	169	CD
cord-015684-q10sx1dm	572	1	This	this	DT
cord-015684-q10sx1dm	572	2	complexity	complexity	NN
cord-015684-q10sx1dm	572	3	requires	require	VBZ
cord-015684-q10sx1dm	572	4	a	a	DT
cord-015684-q10sx1dm	572	5	multifactorial	multifactorial	JJ
cord-015684-q10sx1dm	572	6	approach	approach	NN
cord-015684-q10sx1dm	572	7	to	to	TO
cord-015684-q10sx1dm	572	8	overcome	overcome	VB
cord-015684-q10sx1dm	572	9	the	the	DT
cord-015684-q10sx1dm	572	10	hurdles	hurdle	NNS
cord-015684-q10sx1dm	572	11	that	that	WDT
cord-015684-q10sx1dm	572	12	CNS	CNS	NNP
cord-015684-q10sx1dm	572	13	drug	drug	NN
cord-015684-q10sx1dm	572	14	development	development	NN
cord-015684-q10sx1dm	572	15	faces	face	NNS
cord-015684-q10sx1dm	572	16	at	at	IN
cord-015684-q10sx1dm	572	17	the	the	DT
cord-015684-q10sx1dm	572	18	present	present	JJ
cord-015684-q10sx1dm	572	19	time	time	NN
cord-015684-q10sx1dm	572	20	.	.	.
cord-015684-q10sx1dm	573	1	170	170	CD
cord-015684-q10sx1dm	573	2	 	 	_SP
cord-015684-q10sx1dm	573	3	Polymorphic	polymorphic	JJ
cord-015684-q10sx1dm	573	4	variants	variant	NNS
cord-015684-q10sx1dm	573	5	in	in	IN
cord-015684-q10sx1dm	573	6	the	the	DT
cord-015684-q10sx1dm	573	7	APOE	APOE	NNP
cord-015684-q10sx1dm	573	8	gene	gene	NN
cord-015684-q10sx1dm	573	9	(	(	-LRB-
cord-015684-q10sx1dm	573	10	19q13.2	19q13.2	NNP
cord-015684-q10sx1dm	573	11	)	)	-RRB-
cord-015684-q10sx1dm	573	12	are	be	VBP
cord-015684-q10sx1dm	573	13	associated	associate	VBN
cord-015684-q10sx1dm	573	14	with	with	IN
cord-015684-q10sx1dm	573	15	risk	risk	NN
cord-015684-q10sx1dm	573	16	(	(	-LRB-
cord-015684-q10sx1dm	573	17	APOE-4	APOE-4	NNP
cord-015684-q10sx1dm	573	18	allele	allele	NN
cord-015684-q10sx1dm	573	19	)	)	-RRB-
cord-015684-q10sx1dm	573	20	or	or	CC
cord-015684-q10sx1dm	573	21	protection	protection	NN
cord-015684-q10sx1dm	573	22	(	(	-LRB-
cord-015684-q10sx1dm	573	23	APOE-2	apoe-2	IN
cord-015684-q10sx1dm	573	24	allele	allele	NN
cord-015684-q10sx1dm	573	25	)	)	-RRB-
cord-015684-q10sx1dm	573	26	for	for	IN
cord-015684-q10sx1dm	573	27	AD	ad	NN
cord-015684-q10sx1dm	573	28	.	.	.
cord-015684-q10sx1dm	574	1	8	8	CD
cord-015684-q10sx1dm	574	2	,	,	,
cord-015684-q10sx1dm	574	3	[	[	-LRB-
cord-015684-q10sx1dm	574	4	18	18	CD
cord-015684-q10sx1dm	574	5	]	]	-RRB-
cord-015684-q10sx1dm	574	6	[	[	-LRB-
cord-015684-q10sx1dm	574	7	19	19	CD
cord-015684-q10sx1dm	574	8	]	]	-RRB-
cord-015684-q10sx1dm	574	9	[	[	-LRB-
cord-015684-q10sx1dm	574	10	20	20	CD
cord-015684-q10sx1dm	574	11	]	]	-RRB-
cord-015684-q10sx1dm	575	1	For	for	IN
cord-015684-q10sx1dm	575	2	many	many	JJ
cord-015684-q10sx1dm	575	3	years	year	NNS
cord-015684-q10sx1dm	575	4	,	,	,
cord-015684-q10sx1dm	575	5	alterations	alteration	NNS
cord-015684-q10sx1dm	575	6	in	in	IN
cord-015684-q10sx1dm	575	7	ApoE	ApoE	NNS
cord-015684-q10sx1dm	575	8	and	and	CC
cord-015684-q10sx1dm	575	9	defects	defect	NNS
cord-015684-q10sx1dm	575	10	in	in	IN
cord-015684-q10sx1dm	575	11	the	the	DT
cord-015684-q10sx1dm	575	12	APOE	APOE	NNP
cord-015684-q10sx1dm	575	13	gene	gene	NN
cord-015684-q10sx1dm	575	14	have	have	VBP
cord-015684-q10sx1dm	575	15	been	be	VBN
cord-015684-q10sx1dm	575	16	associated	associate	VBN
cord-015684-q10sx1dm	575	17	with	with	IN
cord-015684-q10sx1dm	575	18	dysfunctions	dysfunction	NNS
cord-015684-q10sx1dm	575	19	in	in	IN
cord-015684-q10sx1dm	575	20	lipid	lipid	NN
cord-015684-q10sx1dm	575	21	metabolism	metabolism	NN
cord-015684-q10sx1dm	575	22	,	,	,
cord-015684-q10sx1dm	575	23	cardiovascular	cardiovascular	JJ
cord-015684-q10sx1dm	575	24	disease	disease	NN
cord-015684-q10sx1dm	575	25	,	,	,
cord-015684-q10sx1dm	575	26	and	and	CC
cord-015684-q10sx1dm	575	27	atherosclerosis	atherosclerosis	NN
cord-015684-q10sx1dm	575	28	.	.	.
cord-015684-q10sx1dm	576	1	During	during	IN
cord-015684-q10sx1dm	576	2	the	the	DT
cord-015684-q10sx1dm	576	3	past	past	JJ
cord-015684-q10sx1dm	576	4	25	25	CD
cord-015684-q10sx1dm	576	5	years	year	NNS
cord-015684-q10sx1dm	576	6	an	an	DT
cord-015684-q10sx1dm	576	7	enormous	enormous	JJ
cord-015684-q10sx1dm	576	8	amount	amount	NN
cord-015684-q10sx1dm	576	9	of	of	IN
cord-015684-q10sx1dm	576	10	studies	study	NNS
cord-015684-q10sx1dm	576	11	clearly	clearly	RB
cord-015684-q10sx1dm	576	12	documented	document	VBD
cord-015684-q10sx1dm	576	13	the	the	DT
cord-015684-q10sx1dm	576	14	role	role	NN
cord-015684-q10sx1dm	576	15	of	of	IN
cord-015684-q10sx1dm	576	16	APOE-4	APOE-4	NNP
cord-015684-q10sx1dm	576	17	as	as	IN
cord-015684-q10sx1dm	576	18	a	a	DT
cord-015684-q10sx1dm	576	19	risk	risk	NN
cord-015684-q10sx1dm	576	20	factor	factor	NN
cord-015684-q10sx1dm	576	21	for	for	IN
cord-015684-q10sx1dm	576	22	AD	ad	NN
cord-015684-q10sx1dm	576	23	,	,	,
cord-015684-q10sx1dm	576	24	an	an	DT
cord-015684-q10sx1dm	576	25	the	the	DT
cord-015684-q10sx1dm	576	26	accumulation	accumulation	NN
cord-015684-q10sx1dm	576	27	of	of	IN
cord-015684-q10sx1dm	576	28	the	the	DT
cord-015684-q10sx1dm	576	29	APOE-4	APOE-4	NNP
cord-015684-q10sx1dm	576	30	allele	allele	NN
cord-015684-q10sx1dm	576	31	has	have	VBZ
cord-015684-q10sx1dm	576	32	been	be	VBN
cord-015684-q10sx1dm	576	33	reported	report	VBN
cord-015684-q10sx1dm	576	34	as	as	IN
cord-015684-q10sx1dm	576	35	a	a	DT
cord-015684-q10sx1dm	576	36	risk	risk	NN
cord-015684-q10sx1dm	576	37	factor	factor	NN
cord-015684-q10sx1dm	576	38	for	for	IN
cord-015684-q10sx1dm	576	39	other	other	JJ
cord-015684-q10sx1dm	576	40	forms	form	NNS
cord-015684-q10sx1dm	576	41	of	of	IN
cord-015684-q10sx1dm	576	42	dementia	dementia	NN
cord-015684-q10sx1dm	576	43	and	and	CC
cord-015684-q10sx1dm	576	44	CNS	CNS	NNP
cord-015684-q10sx1dm	576	45	disorders	disorder	NNS
cord-015684-q10sx1dm	576	46	.	.	.
cord-015684-q10sx1dm	577	1	8	8	CD
cord-015684-q10sx1dm	577	2	,	,	,
cord-015684-q10sx1dm	577	3	[	[	-LRB-
cord-015684-q10sx1dm	577	4	18	18	CD
cord-015684-q10sx1dm	577	5	]	]	-RRB-
cord-015684-q10sx1dm	577	6	[	[	-LRB-
cord-015684-q10sx1dm	577	7	19	19	CD
cord-015684-q10sx1dm	577	8	]	]	-RRB-
cord-015684-q10sx1dm	578	1	[	[	-LRB-
cord-015684-q10sx1dm	578	2	20	20	CD
cord-015684-q10sx1dm	578	3	]	]	-RRB-
cord-015684-q10sx1dm	578	4	APOE-4	APOE-4	NNPS
cord-015684-q10sx1dm	578	5	may	may	MD
cord-015684-q10sx1dm	578	6	infl	infl	VB
cord-015684-q10sx1dm	578	7	uence	uence	NN
cord-015684-q10sx1dm	578	8	AD	ad	NN
cord-015684-q10sx1dm	578	9	pathology	pathology	NN
cord-015684-q10sx1dm	578	10	interacting	interact	VBG
cord-015684-q10sx1dm	578	11	with	with	IN
cord-015684-q10sx1dm	578	12	APP	app	NN
cord-015684-q10sx1dm	578	13	metabolism	metabolism	NN
cord-015684-q10sx1dm	578	14	and	and	CC
cord-015684-q10sx1dm	578	15	ABP	ABP	NNP
cord-015684-q10sx1dm	578	16	accumulation	accumulation	NN
cord-015684-q10sx1dm	578	17	,	,	,
cord-015684-q10sx1dm	578	18	enhancing	enhance	VBG
cord-015684-q10sx1dm	578	19	hyperphosphorylation	hyperphosphorylation	NN
cord-015684-q10sx1dm	578	20	of	of	IN
cord-015684-q10sx1dm	578	21	tau	tau	NNP
cord-015684-q10sx1dm	578	22	protein	protein	NNP
cord-015684-q10sx1dm	578	23	and	and	CC
cord-015684-q10sx1dm	578	24	NFT	NFT	NNP
cord-015684-q10sx1dm	578	25	formation	formation	NN
cord-015684-q10sx1dm	578	26	,	,	,
cord-015684-q10sx1dm	578	27	reducing	reduce	VBG
cord-015684-q10sx1dm	578	28	choline	choline	NN
cord-015684-q10sx1dm	578	29	acetyltransferase	acetyltransferase	NN
cord-015684-q10sx1dm	578	30	activity	activity	NN
cord-015684-q10sx1dm	578	31	,	,	,
cord-015684-q10sx1dm	578	32	increasing	increase	VBG
cord-015684-q10sx1dm	578	33	oxidative	oxidative	JJ
cord-015684-q10sx1dm	578	34	processes	process	NNS
cord-015684-q10sx1dm	578	35	,	,	,
cord-015684-q10sx1dm	578	36	modifying	modify	VBG
cord-015684-q10sx1dm	578	37	infl	infl	NN
cord-015684-q10sx1dm	578	38	ammation	ammation	NN
cord-015684-q10sx1dm	578	39	-	-	HYPH
cord-015684-q10sx1dm	578	40	related	relate	VBN
cord-015684-q10sx1dm	578	41	neuroimmunotrophic	neuroimmunotrophic	JJ
cord-015684-q10sx1dm	578	42	activity	activity	NN
cord-015684-q10sx1dm	578	43	and	and	CC
cord-015684-q10sx1dm	578	44	glial	glial	JJ
cord-015684-q10sx1dm	578	45	activation	activation	NN
cord-015684-q10sx1dm	578	46	,	,	,
cord-015684-q10sx1dm	578	47	altering	alter	VBG
cord-015684-q10sx1dm	578	48	lipid	lipid	NN
cord-015684-q10sx1dm	578	49	metabolism	metabolism	NN
cord-015684-q10sx1dm	578	50	,	,	,
cord-015684-q10sx1dm	578	51	lipid	lipid	NN
cord-015684-q10sx1dm	578	52	transport	transport	NN
cord-015684-q10sx1dm	578	53	and	and	CC
cord-015684-q10sx1dm	578	54	membrane	membrane	NN
cord-015684-q10sx1dm	578	55	biosynthesis	biosynthesis	NN
cord-015684-q10sx1dm	578	56	in	in	IN
cord-015684-q10sx1dm	578	57	sprouting	sprout	VBG
cord-015684-q10sx1dm	578	58	and	and	CC
cord-015684-q10sx1dm	578	59	synaptic	synaptic	JJ
cord-015684-q10sx1dm	578	60	remodelling	remodelling	NN
cord-015684-q10sx1dm	578	61	,	,	,
cord-015684-q10sx1dm	578	62	and	and	CC
cord-015684-q10sx1dm	578	63	inducing	induce	VBG
cord-015684-q10sx1dm	578	64	neuronal	neuronal	JJ
cord-015684-q10sx1dm	578	65	apoptosis	apoptosis	NN
cord-015684-q10sx1dm	578	66	.	.	.
cord-015684-q10sx1dm	579	1	8	8	CD
cord-015684-q10sx1dm	579	2	,	,	,
cord-015684-q10sx1dm	579	3	[	[	-LRB-
cord-015684-q10sx1dm	579	4	18	18	CD
cord-015684-q10sx1dm	579	5	]	]	-RRB-
cord-015684-q10sx1dm	579	6	[	[	-LRB-
cord-015684-q10sx1dm	579	7	19	19	CD
cord-015684-q10sx1dm	579	8	]	]	-RRB-
cord-015684-q10sx1dm	579	9	[	[	-LRB-
cord-015684-q10sx1dm	579	10	20	20	CD
cord-015684-q10sx1dm	579	11	]	]	-RRB-
cord-015684-q10sx1dm	579	12	 	 	_SP
cord-015684-q10sx1dm	579	13	Different	different	JJ
cord-015684-q10sx1dm	579	14	APOE	APOE	NNP
cord-015684-q10sx1dm	579	15	genotypes	genotype	NNS
cord-015684-q10sx1dm	579	16	confer	confer	VBP
cord-015684-q10sx1dm	579	17	specifi	specifi	NNP
cord-015684-q10sx1dm	579	18	c	c	NN
cord-015684-q10sx1dm	579	19	phenotypic	phenotypic	JJ
cord-015684-q10sx1dm	579	20	profi	profi	NNP
cord-015684-q10sx1dm	579	21	les	les	FW
cord-015684-q10sx1dm	579	22	to	to	IN
cord-015684-q10sx1dm	579	23	AD	ad	NN
cord-015684-q10sx1dm	579	24	patients	patient	NNS
cord-015684-q10sx1dm	579	25	.	.	.
cord-015684-q10sx1dm	580	1	Some	some	DT
cord-015684-q10sx1dm	580	2	of	of	IN
cord-015684-q10sx1dm	580	3	these	these	DT
cord-015684-q10sx1dm	580	4	profi	profi	NNP
cord-015684-q10sx1dm	580	5	les	les	FW
cord-015684-q10sx1dm	580	6	may	may	MD
cord-015684-q10sx1dm	580	7	add	add	VB
cord-015684-q10sx1dm	580	8	risk	risk	NN
cord-015684-q10sx1dm	580	9	or	or	CC
cord-015684-q10sx1dm	580	10	benefi	benefi	NNP
cord-015684-q10sx1dm	580	11	t	t	NN
cord-015684-q10sx1dm	580	12	when	when	WRB
cord-015684-q10sx1dm	580	13	the	the	DT
cord-015684-q10sx1dm	580	14	patients	patient	NNS
cord-015684-q10sx1dm	580	15	are	be	VBP
cord-015684-q10sx1dm	580	16	treated	treat	VBN
cord-015684-q10sx1dm	580	17	with	with	IN
cord-015684-q10sx1dm	580	18	conventional	conventional	JJ
cord-015684-q10sx1dm	580	19	drugs	drug	NNS
cord-015684-q10sx1dm	580	20	,	,	,
cord-015684-q10sx1dm	580	21	and	and	CC
cord-015684-q10sx1dm	580	22	in	in	IN
cord-015684-q10sx1dm	580	23	many	many	JJ
cord-015684-q10sx1dm	580	24	instances	instance	NNS
cord-015684-q10sx1dm	580	25	the	the	DT
cord-015684-q10sx1dm	580	26	clinical	clinical	JJ
cord-015684-q10sx1dm	580	27	phenotype	phenotype	NN
cord-015684-q10sx1dm	580	28	demands	demand	VBZ
cord-015684-q10sx1dm	580	29	the	the	DT
cord-015684-q10sx1dm	580	30	administration	administration	NN
cord-015684-q10sx1dm	580	31	of	of	IN
cord-015684-q10sx1dm	580	32	additional	additional	JJ
cord-015684-q10sx1dm	580	33	drugs	drug	NNS
cord-015684-q10sx1dm	580	34	which	which	WDT
cord-015684-q10sx1dm	580	35	increase	increase	VBP
cord-015684-q10sx1dm	580	36	the	the	DT
cord-015684-q10sx1dm	580	37	complexity	complexity	NN
cord-015684-q10sx1dm	580	38	of	of	IN
cord-015684-q10sx1dm	580	39	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	580	40	protocols	protocol	NNS
cord-015684-q10sx1dm	580	41	.	.	.
cord-015684-q10sx1dm	581	1	From	from	IN
cord-015684-q10sx1dm	581	2	studies	study	NNS
cord-015684-q10sx1dm	581	3	designed	design	VBN
cord-015684-q10sx1dm	581	4	to	to	TO
cord-015684-q10sx1dm	581	5	defi	defi	NNP
cord-015684-q10sx1dm	581	6	ne	ne	NNP
cord-015684-q10sx1dm	581	7	APOE	APOE	NNP
cord-015684-q10sx1dm	581	8	-	-	HYPH
cord-015684-q10sx1dm	581	9	related	relate	VBN
cord-015684-q10sx1dm	581	10	AD	ad	NN
cord-015684-q10sx1dm	581	11	phenotypes	phenotype	NNS
cord-015684-q10sx1dm	581	12	,	,	,
cord-015684-q10sx1dm	581	13	8	8	CD
cord-015684-q10sx1dm	581	14	,	,	,
cord-015684-q10sx1dm	581	15	[	[	-LRB-
cord-015684-q10sx1dm	581	16	16	16	CD
cord-015684-q10sx1dm	581	17	]	]	-RRB-
cord-015684-q10sx1dm	581	18	[	[	-LRB-
cord-015684-q10sx1dm	581	19	17	17	CD
cord-015684-q10sx1dm	581	20	]	]	-RRB-
cord-015684-q10sx1dm	581	21	[	[	-LRB-
cord-015684-q10sx1dm	581	22	18	18	CD
cord-015684-q10sx1dm	581	23	]	]	-RRB-
cord-015684-q10sx1dm	581	24	[	[	-LRB-
cord-015684-q10sx1dm	581	25	19	19	CD
cord-015684-q10sx1dm	581	26	]	]	-RRB-
cord-015684-q10sx1dm	581	27	[	[	-LRB-
cord-015684-q10sx1dm	581	28	20	20	CD
cord-015684-q10sx1dm	581	29	]	]	-RRB-
cord-015684-q10sx1dm	581	30	[	[	-LRB-
cord-015684-q10sx1dm	581	31	21	21	CD
cord-015684-q10sx1dm	581	32	]	]	-RRB-
cord-015684-q10sx1dm	581	33	[	[	-LRB-
cord-015684-q10sx1dm	581	34	22	22	CD
cord-015684-q10sx1dm	581	35	]	]	-RRB-
cord-015684-q10sx1dm	581	36	62	62	CD
cord-015684-q10sx1dm	581	37	,	,	,
cord-015684-q10sx1dm	581	38	63	63	CD
cord-015684-q10sx1dm	581	39	,	,	,
cord-015684-q10sx1dm	581	40	[	[	-LRB-
cord-015684-q10sx1dm	581	41	74	74	CD
cord-015684-q10sx1dm	581	42	]	]	-RRB-
cord-015684-q10sx1dm	581	43	[	[	-LRB-
cord-015684-q10sx1dm	581	44	75	75	CD
cord-015684-q10sx1dm	581	45	]	]	-RRB-
cord-015684-q10sx1dm	581	46	[	[	-LRB-
cord-015684-q10sx1dm	581	47	76	76	CD
cord-015684-q10sx1dm	581	48	]	]	-RRB-
cord-015684-q10sx1dm	581	49	[	[	-LRB-
cord-015684-q10sx1dm	581	50	77	77	CD
cord-015684-q10sx1dm	581	51	]	]	-RRB-
cord-015684-q10sx1dm	581	52	109	109	CD
cord-015684-q10sx1dm	581	53	,	,	,
cord-015684-q10sx1dm	581	54	110	110	CD
cord-015684-q10sx1dm	581	55	several	several	JJ
cord-015684-q10sx1dm	581	56	confi	confi	NN
cord-015684-q10sx1dm	581	57	rmed	rme	VBN
cord-015684-q10sx1dm	581	58	conclusions	conclusion	NNS
cord-015684-q10sx1dm	581	59	can	can	MD
cord-015684-q10sx1dm	581	60	be	be	VB
cord-015684-q10sx1dm	581	61	drawn	draw	VBN
cord-015684-q10sx1dm	581	62	:	:	:
cord-015684-q10sx1dm	581	63	(	(	-LRB-
cord-015684-q10sx1dm	581	64	i	i	NN
cord-015684-q10sx1dm	581	65	)	)	-RRB-
cord-015684-q10sx1dm	582	1	the	the	DT
cord-015684-q10sx1dm	582	2	ageat	ageat	NNP
cord-015684-q10sx1dm	582	3	-	-	HYPH
cord-015684-q10sx1dm	582	4	onset	onset	NN
cord-015684-q10sx1dm	582	5	is	be	VBZ
cord-015684-q10sx1dm	582	6	5	5	CD
cord-015684-q10sx1dm	582	7	-	-	SYM
cord-015684-q10sx1dm	582	8	10	10	CD
cord-015684-q10sx1dm	582	9	years	year	NNS
cord-015684-q10sx1dm	582	10	earlier	early	RBR
cord-015684-q10sx1dm	582	11	in	in	IN
cord-015684-q10sx1dm	582	12	approximately	approximately	RB
cord-015684-q10sx1dm	582	13	80	80	CD
cord-015684-q10sx1dm	582	14	%	%	NN
cord-015684-q10sx1dm	582	15	of	of	IN
cord-015684-q10sx1dm	582	16	AD	ad	NN
cord-015684-q10sx1dm	582	17	cases	case	NNS
cord-015684-q10sx1dm	582	18	harbouring	harbour	VBG
cord-015684-q10sx1dm	582	19	the	the	DT
cord-015684-q10sx1dm	582	20	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	582	21	genotype	genotype	NN
cord-015684-q10sx1dm	582	22	;	;	,
cord-015684-q10sx1dm	582	23	(	(	-LRB-
cord-015684-q10sx1dm	582	24	ii	ii	NN
cord-015684-q10sx1dm	582	25	)	)	-RRB-
cord-015684-q10sx1dm	583	1	the	the	DT
cord-015684-q10sx1dm	583	2	serum	serum	NN
cord-015684-q10sx1dm	583	3	levels	level	NNS
cord-015684-q10sx1dm	583	4	of	of	IN
cord-015684-q10sx1dm	583	5	ApoE	ApoE	NNS
cord-015684-q10sx1dm	583	6	are	be	VBP
cord-015684-q10sx1dm	583	7	the	the	DT
cord-015684-q10sx1dm	583	8	lowest	low	JJS
cord-015684-q10sx1dm	583	9	in	in	IN
cord-015684-q10sx1dm	583	10	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	583	11	,	,	,
cord-015684-q10sx1dm	583	12	intermediate	intermediate	JJ
cord-015684-q10sx1dm	583	13	in	in	IN
cord-015684-q10sx1dm	583	14	APOE-3/3	APOE-3/3	NNP
cord-015684-q10sx1dm	583	15	and	and	CC
cord-015684-q10sx1dm	583	16	APOE-3/4	APOE-3/4	NNP
cord-015684-q10sx1dm	583	17	,	,	,
cord-015684-q10sx1dm	583	18	and	and	CC
cord-015684-q10sx1dm	583	19	highest	high	JJS
cord-015684-q10sx1dm	583	20	in	in	IN
cord-015684-q10sx1dm	583	21	APOE-2/3	APOE-2/3	NNP
cord-015684-q10sx1dm	583	22	and	and	CC
cord-015684-q10sx1dm	583	23	APOE-2/4	APOE-2/4	NNP
cord-015684-q10sx1dm	583	24	;	;	,
cord-015684-q10sx1dm	583	25	(	(	-LRB-
cord-015684-q10sx1dm	583	26	iii	iii	NN
cord-015684-q10sx1dm	583	27	)	)	-RRB-
cord-015684-q10sx1dm	583	28	serum	serum	NN
cord-015684-q10sx1dm	583	29	cholesterol	cholesterol	NN
cord-015684-q10sx1dm	583	30	levels	level	NNS
cord-015684-q10sx1dm	583	31	are	be	VBP
cord-015684-q10sx1dm	583	32	higher	high	JJR
cord-015684-q10sx1dm	583	33	in	in	IN
cord-015684-q10sx1dm	583	34	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	583	35	than	than	IN
cord-015684-q10sx1dm	583	36	in	in	IN
cord-015684-q10sx1dm	583	37	the	the	DT
cord-015684-q10sx1dm	583	38	other	other	JJ
cord-015684-q10sx1dm	583	39	genotypes	genotype	NNS
cord-015684-q10sx1dm	583	40	;	;	,
cord-015684-q10sx1dm	583	41	(	(	-LRB-
cord-015684-q10sx1dm	583	42	iv	iv	LS
cord-015684-q10sx1dm	583	43	)	)	-RRB-
cord-015684-q10sx1dm	583	44	HDL	hdl	NN
cord-015684-q10sx1dm	583	45	-	-	HYPH
cord-015684-q10sx1dm	583	46	cholesterol	cholesterol	NN
cord-015684-q10sx1dm	583	47	levels	level	NNS
cord-015684-q10sx1dm	583	48	tend	tend	VBP
cord-015684-q10sx1dm	583	49	to	to	TO
cord-015684-q10sx1dm	583	50	be	be	VB
cord-015684-q10sx1dm	583	51	lower	low	JJR
cord-015684-q10sx1dm	583	52	in	in	IN
cord-015684-q10sx1dm	583	53	APOE-3	APOE-3	NNP
cord-015684-q10sx1dm	583	54	homozygotes	homozygote	NNS
cord-015684-q10sx1dm	583	55	than	than	IN
cord-015684-q10sx1dm	583	56	in	in	IN
cord-015684-q10sx1dm	583	57	APOE-4	APOE-4	NNP
cord-015684-q10sx1dm	583	58	allele	allele	NN
cord-015684-q10sx1dm	583	59	carriers	carrier	NNS
cord-015684-q10sx1dm	583	60	;	;	,
cord-015684-q10sx1dm	583	61	(	(	-LRB-
cord-015684-q10sx1dm	583	62	v	v	LS
cord-015684-q10sx1dm	583	63	)	)	-RRB-
cord-015684-q10sx1dm	583	64	LDL	ldl	NN
cord-015684-q10sx1dm	583	65	-	-	HYPH
cord-015684-q10sx1dm	583	66	cholesterol	cholesterol	NN
cord-015684-q10sx1dm	583	67	levels	level	NNS
cord-015684-q10sx1dm	583	68	are	be	VBP
cord-015684-q10sx1dm	583	69	systematically	systematically	RB
cord-015684-q10sx1dm	583	70	higher	high	JJR
cord-015684-q10sx1dm	583	71	in	in	IN
cord-015684-q10sx1dm	583	72	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	583	73	than	than	IN
cord-015684-q10sx1dm	583	74	in	in	IN
cord-015684-q10sx1dm	583	75	any	any	DT
cord-015684-q10sx1dm	583	76	other	other	JJ
cord-015684-q10sx1dm	583	77	genotype	genotype	NN
cord-015684-q10sx1dm	583	78	;	;	,
cord-015684-q10sx1dm	583	79	(	(	-LRB-
cord-015684-q10sx1dm	583	80	vi	vi	NNP
cord-015684-q10sx1dm	583	81	)	)	-RRB-
cord-015684-q10sx1dm	583	82	triglyceride	triglyceride	NN
cord-015684-q10sx1dm	583	83	levels	level	NNS
cord-015684-q10sx1dm	583	84	are	be	VBP
cord-015684-q10sx1dm	583	85	signifi	signifi	NNP
cord-015684-q10sx1dm	583	86	cantly	cantly	RB
cord-015684-q10sx1dm	583	87	lower	lower	RBR
cord-015684-q10sx1dm	583	88	in	in	IN
cord-015684-q10sx1dm	583	89	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	583	90	;	;	:
cord-015684-q10sx1dm	583	91	(	(	-LRB-
cord-015684-q10sx1dm	583	92	vii	vii	NN
cord-015684-q10sx1dm	583	93	)	)	-RRB-
cord-015684-q10sx1dm	583	94	nitric	nitric	NN
cord-015684-q10sx1dm	583	95	oxide	oxide	NN
cord-015684-q10sx1dm	583	96	levels	level	NNS
cord-015684-q10sx1dm	583	97	are	be	VBP
cord-015684-q10sx1dm	583	98	slightly	slightly	RB
cord-015684-q10sx1dm	583	99	lower	low	JJR
cord-015684-q10sx1dm	583	100	in	in	IN
cord-015684-q10sx1dm	583	101	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	583	102	;	;	:
cord-015684-q10sx1dm	584	1	(	(	-LRB-
cord-015684-q10sx1dm	584	2	viii	viii	NNP
cord-015684-q10sx1dm	584	3	)	)	-RRB-
cord-015684-q10sx1dm	584	4	serum	serum	NN
cord-015684-q10sx1dm	584	5	ABP	ABP	NNP
cord-015684-q10sx1dm	584	6	levels	level	NNS
cord-015684-q10sx1dm	584	7	do	do	VBP
cord-015684-q10sx1dm	584	8	not	not	RB
cord-015684-q10sx1dm	584	9	differ	differ	VB
cord-015684-q10sx1dm	584	10	between	between	IN
cord-015684-q10sx1dm	584	11	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	584	12	and	and	CC
cord-015684-q10sx1dm	584	13	the	the	DT
cord-015684-q10sx1dm	584	14	other	other	JJ
cord-015684-q10sx1dm	584	15	most	most	RBS
cord-015684-q10sx1dm	584	16	frequent	frequent	JJ
cord-015684-q10sx1dm	584	17	genotypes	genotype	NNS
cord-015684-q10sx1dm	584	18	(	(	-LRB-
cord-015684-q10sx1dm	584	19	APOE-3/3	APOE-3/3	NNP
cord-015684-q10sx1dm	584	20	,	,	,
cord-015684-q10sx1dm	584	21	APOE-3/4	APOE-3/4	NNP
cord-015684-q10sx1dm	584	22	)	)	-RRB-
cord-015684-q10sx1dm	584	23	;	;	:
cord-015684-q10sx1dm	584	24	(	(	-LRB-
cord-015684-q10sx1dm	584	25	ix	ix	LS
cord-015684-q10sx1dm	584	26	)	)	-RRB-
cord-015684-q10sx1dm	584	27	blood	blood	NN
cord-015684-q10sx1dm	584	28	histamine	histamine	NN
cord-015684-q10sx1dm	584	29	levels	level	NNS
cord-015684-q10sx1dm	584	30	are	be	VBP
cord-015684-q10sx1dm	584	31	dramatically	dramatically	RB
cord-015684-q10sx1dm	584	32	reduced	reduce	VBN
cord-015684-q10sx1dm	584	33	in	in	IN
cord-015684-q10sx1dm	584	34	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	584	35	as	as	IN
cord-015684-q10sx1dm	584	36	compared	compare	VBN
cord-015684-q10sx1dm	584	37	with	with	IN
cord-015684-q10sx1dm	584	38	the	the	DT
cord-015684-q10sx1dm	584	39	other	other	JJ
cord-015684-q10sx1dm	584	40	genotypes	genotype	NNS
cord-015684-q10sx1dm	584	41	;	;	:
cord-015684-q10sx1dm	585	1	(	(	-LRB-
cord-015684-q10sx1dm	585	2	x	x	LS
cord-015684-q10sx1dm	585	3	)	)	-RRB-
cord-015684-q10sx1dm	585	4	brain	brain	NN
cord-015684-q10sx1dm	585	5	atrophy	atrophy	NN
cord-015684-q10sx1dm	585	6	is	be	VBZ
cord-015684-q10sx1dm	585	7	markedly	markedly	RB
cord-015684-q10sx1dm	585	8	increased	increase	VBN
cord-015684-q10sx1dm	585	9	in	in	IN
cord-015684-q10sx1dm	585	10	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	585	11	>	>	XX
cord-015684-q10sx1dm	586	1	APOE-3/4	APOE-3/4	NNP
cord-015684-q10sx1dm	587	1	>	>	XX
cord-015684-q10sx1dm	588	1	APOE-3/3	APOE-3/3	NNP
cord-015684-q10sx1dm	589	1	;	;	:
cord-015684-q10sx1dm	589	2	(	(	-LRB-
cord-015684-q10sx1dm	589	3	xi	xi	NNP
cord-015684-q10sx1dm	589	4	)	)	-RRB-
cord-015684-q10sx1dm	589	5	brain	brain	NN
cord-015684-q10sx1dm	589	6	mapping	mapping	NN
cord-015684-q10sx1dm	589	7	activity	activity	NN
cord-015684-q10sx1dm	589	8	shows	show	VBZ
cord-015684-q10sx1dm	589	9	a	a	DT
cord-015684-q10sx1dm	589	10	signifi	signifi	NN
cord-015684-q10sx1dm	589	11	ca	can	MD
cord-015684-q10sx1dm	589	12	nt	not	RB
cord-015684-q10sx1dm	589	13	increase	increase	VB
cord-015684-q10sx1dm	589	14	in	in	IN
cord-015684-q10sx1dm	589	15	slow	slow	JJ
cord-015684-q10sx1dm	589	16	wave	wave	NN
cord-015684-q10sx1dm	589	17	activity	activity	NN
cord-015684-q10sx1dm	589	18	in	in	IN
cord-015684-q10sx1dm	589	19	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	589	20	from	from	IN
cord-015684-q10sx1dm	589	21	early	early	JJ
cord-015684-q10sx1dm	589	22	stages	stage	NNS
cord-015684-q10sx1dm	589	23	of	of	IN
cord-015684-q10sx1dm	589	24	the	the	DT
cord-015684-q10sx1dm	589	25	disease	disease	NN
cord-015684-q10sx1dm	589	26	(	(	-LRB-
cord-015684-q10sx1dm	589	27	Fig	Fig	NNP
cord-015684-q10sx1dm	589	28	.	.	.
cord-015684-q10sx1dm	589	29	40.4	40.4	CD
cord-015684-q10sx1dm	589	30	)	)	-RRB-
cord-015684-q10sx1dm	589	31	;	;	:
cord-015684-q10sx1dm	589	32	(	(	-LRB-
cord-015684-q10sx1dm	589	33	xii	xii	NN
cord-015684-q10sx1dm	589	34	)	)	-RRB-
cord-015684-q10sx1dm	589	35	brain	brain	NN
cord-015684-q10sx1dm	589	36	hemodynamics	hemodynamic	NNS
cord-015684-q10sx1dm	589	37	,	,	,
cord-015684-q10sx1dm	589	38	as	as	IN
cord-015684-q10sx1dm	589	39	refl	refl	NNP
cord-015684-q10sx1dm	589	40	ected	ecte	VBN
cord-015684-q10sx1dm	589	41	by	by	IN
cord-015684-q10sx1dm	589	42	reduced	reduce	VBN
cord-015684-q10sx1dm	589	43	brain	brain	NN
cord-015684-q10sx1dm	589	44	blood	blood	NN
cord-015684-q10sx1dm	590	1	fl	fl	NNP
cord-015684-q10sx1dm	591	1	ow	ow	UH
cord-015684-q10sx1dm	591	2	velocity	velocity	NN
cord-015684-q10sx1dm	591	3	and	and	CC
cord-015684-q10sx1dm	591	4	increase	increase	VB
cord-015684-q10sx1dm	591	5	pulsatility	pulsatility	NN
cord-015684-q10sx1dm	591	6	and	and	CC
cord-015684-q10sx1dm	591	7	resistance	resistance	NN
cord-015684-q10sx1dm	591	8	indices	index	NNS
cord-015684-q10sx1dm	591	9	,	,	,
cord-015684-q10sx1dm	591	10	is	be	VBZ
cord-015684-q10sx1dm	591	11	signifi	signifi	NNP
cord-015684-q10sx1dm	591	12	cantly	cantly	RB
cord-015684-q10sx1dm	591	13	worst	worst	RBS
cord-015684-q10sx1dm	591	14	in	in	IN
cord-015684-q10sx1dm	591	15	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	591	16	(	(	-LRB-
cord-015684-q10sx1dm	591	17	and	and	CC
cord-015684-q10sx1dm	591	18	in	in	IN
cord-015684-q10sx1dm	591	19	APOE-4	APOE-4	NNP
cord-015684-q10sx1dm	591	20	carriers	carrier	NNS
cord-015684-q10sx1dm	591	21	,	,	,
cord-015684-q10sx1dm	591	22	in	in	IN
cord-015684-q10sx1dm	591	23	general	general	JJ
cord-015684-q10sx1dm	591	24	,	,	,
cord-015684-q10sx1dm	591	25	as	as	IN
cord-015684-q10sx1dm	591	26	compared	compare	VBN
cord-015684-q10sx1dm	591	27	with	with	IN
cord-015684-q10sx1dm	591	28	APOE-3	APOE-3	NNP
cord-015684-q10sx1dm	591	29	carriers	carrier	NNS
cord-015684-q10sx1dm	591	30	)	)	-RRB-
cord-015684-q10sx1dm	591	31	;	;	:
cord-015684-q10sx1dm	591	32	(	(	-LRB-
cord-015684-q10sx1dm	591	33	xiii	xiii	NNP
cord-015684-q10sx1dm	591	34	)	)	-RRB-
cord-015684-q10sx1dm	591	35	lymphocyte	lymphocyte	NN
cord-015684-q10sx1dm	591	36	apoptosis	apoptosis	NN
cord-015684-q10sx1dm	591	37	is	be	VBZ
cord-015684-q10sx1dm	591	38	markedly	markedly	RB
cord-015684-q10sx1dm	591	39	enhanced	enhance	VBN
cord-015684-q10sx1dm	591	40	in	in	IN
cord-015684-q10sx1dm	591	41	APOE-4	APOE-4	NNP
cord-015684-q10sx1dm	591	42	carriers	carrier	NNS
cord-015684-q10sx1dm	591	43	;	;	,
cord-015684-q10sx1dm	591	44	(	(	-LRB-
cord-015684-q10sx1dm	591	45	xiv	xiv	NNP
cord-015684-q10sx1dm	591	46	)	)	-RRB-
cord-015684-q10sx1dm	591	47	cognitive	cognitive	JJ
cord-015684-q10sx1dm	591	48	deterioration	deterioration	NN
cord-015684-q10sx1dm	591	49	is	be	VBZ
cord-015684-q10sx1dm	591	50	faster	fast	JJR
cord-015684-q10sx1dm	591	51	in	in	IN
cord-015684-q10sx1dm	591	52	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	591	53	patients	patient	NNS
cord-015684-q10sx1dm	591	54	than	than	IN
cord-015684-q10sx1dm	591	55	in	in	IN
cord-015684-q10sx1dm	591	56	carriers	carrier	NNS
cord-015684-q10sx1dm	591	57	of	of	IN
cord-015684-q10sx1dm	591	58	any	any	DT
cord-015684-q10sx1dm	591	59	other	other	JJ
cord-015684-q10sx1dm	591	60	APOE	APOE	NNP
cord-015684-q10sx1dm	591	61	genotype	genotype	NN
cord-015684-q10sx1dm	591	62	;	;	,
cord-015684-q10sx1dm	591	63	(	(	-LRB-
cord-015684-q10sx1dm	591	64	xv	xv	NNP
cord-015684-q10sx1dm	591	65	)	)	-RRB-
cord-015684-q10sx1dm	591	66	occasionally	occasionally	RB
cord-015684-q10sx1dm	591	67	,	,	,
cord-015684-q10sx1dm	591	68	in	in	IN
cord-015684-q10sx1dm	591	69	approximately	approximately	RB
cord-015684-q10sx1dm	591	70	3	3	CD
cord-015684-q10sx1dm	591	71	-	-	SYM
cord-015684-q10sx1dm	591	72	8	8	CD
cord-015684-q10sx1dm	591	73	%	%	NN
cord-015684-q10sx1dm	591	74	of	of	IN
cord-015684-q10sx1dm	591	75	the	the	DT
cord-015684-q10sx1dm	591	76	AD	ad	NN
cord-015684-q10sx1dm	591	77	cases	case	NNS
cord-015684-q10sx1dm	591	78	,	,	,
cord-015684-q10sx1dm	591	79	the	the	DT
cord-015684-q10sx1dm	591	80	presence	presence	NN
cord-015684-q10sx1dm	591	81	of	of	IN
cord-015684-q10sx1dm	591	82	some	some	DT
cord-015684-q10sx1dm	591	83	dementia	dementia	NN
cord-015684-q10sx1dm	591	84	-	-	HYPH
cord-015684-q10sx1dm	591	85	related	relate	VBN
cord-015684-q10sx1dm	591	86	metabolic	metabolic	JJ
cord-015684-q10sx1dm	591	87	dysfunctions	dysfunction	NNS
cord-015684-q10sx1dm	591	88	(	(	-LRB-
cord-015684-q10sx1dm	591	89	e.g.	e.g.	RB
cord-015684-q10sx1dm	591	90	,	,	,
cord-015684-q10sx1dm	591	91	iron	iron	NN
cord-015684-q10sx1dm	591	92	,	,	,
cord-015684-q10sx1dm	591	93	folic	folic	JJ
cord-015684-q10sx1dm	591	94	acid	acid	NN
cord-015684-q10sx1dm	591	95	,	,	,
cord-015684-q10sx1dm	591	96	vitamin	vitamin	NN
cord-015684-q10sx1dm	591	97	B12	b12	NN
cord-015684-q10sx1dm	591	98	defi	defi	NN
cord-015684-q10sx1dm	591	99	ciencies	ciencie	NNS
cord-015684-q10sx1dm	591	100	)	)	-RRB-
cord-015684-q10sx1dm	591	101	accumulate	accumulate	VBP
cord-015684-q10sx1dm	591	102	in	in	IN
cord-015684-q10sx1dm	591	103	APOE-4	APOE-4	NNP
cord-015684-q10sx1dm	591	104	carriers	carrier	NNS
cord-015684-q10sx1dm	591	105	more	more	JJR
cord-015684-q10sx1dm	591	106	than	than	IN
cord-015684-q10sx1dm	591	107	in	in	IN
cord-015684-q10sx1dm	591	108	APOE-3	APOE-3	NNP
cord-015684-q10sx1dm	591	109	carriers	carrier	NNS
cord-015684-q10sx1dm	591	110	;	;	,
cord-015684-q10sx1dm	591	111	(	(	-LRB-
cord-015684-q10sx1dm	591	112	xvi	xvi	NNP
cord-015684-q10sx1dm	591	113	)	)	-RRB-
cord-015684-q10sx1dm	591	114	some	some	DT
cord-015684-q10sx1dm	591	115	behavioral	behavioral	JJ
cord-015684-q10sx1dm	591	116	disturbances	disturbance	NNS
cord-015684-q10sx1dm	591	117	(	(	-LRB-
cord-015684-q10sx1dm	591	118	bizarre	bizarre	JJ
cord-015684-q10sx1dm	591	119	behaviors	behavior	NNS
cord-015684-q10sx1dm	591	120	,	,	,
cord-015684-q10sx1dm	591	121	psychotic	psychotic	JJ
cord-015684-q10sx1dm	591	122	symptoms	symptom	NNS
cord-015684-q10sx1dm	591	123	)	)	-RRB-
cord-015684-q10sx1dm	591	124	,	,	,
cord-015684-q10sx1dm	591	125	alterations	alteration	NNS
cord-015684-q10sx1dm	591	126	in	in	IN
cord-015684-q10sx1dm	591	127	circadian	circadian	NN
cord-015684-q10sx1dm	591	128	rhythm	rhythm	NN
cord-015684-q10sx1dm	591	129	patterns	pattern	NNS
cord-015684-q10sx1dm	591	130	(	(	-LRB-
cord-015684-q10sx1dm	591	131	e.g.	e.g.	RB
cord-015684-q10sx1dm	591	132	,	,	,
cord-015684-q10sx1dm	591	133	sleep	sleep	NN
cord-015684-q10sx1dm	591	134	disorders	disorder	NNS
cord-015684-q10sx1dm	591	135	)	)	-RRB-
cord-015684-q10sx1dm	591	136	,	,	,
cord-015684-q10sx1dm	591	137	and	and	CC
cord-015684-q10sx1dm	591	138	mood	mood	NN
cord-015684-q10sx1dm	591	139	disorders	disorder	NNS
cord-015684-q10sx1dm	591	140	(	(	-LRB-
cord-015684-q10sx1dm	591	141	anxiety	anxiety	NN
cord-015684-q10sx1dm	591	142	,	,	,
cord-015684-q10sx1dm	591	143	depression	depression	NN
cord-015684-q10sx1dm	591	144	)	)	-RRB-
cord-015684-q10sx1dm	591	145	are	be	VBP
cord-015684-q10sx1dm	591	146	slightly	slightly	RB
cord-015684-q10sx1dm	591	147	more	more	RBR
cord-015684-q10sx1dm	591	148	frequent	frequent	JJ
cord-015684-q10sx1dm	591	149	in	in	IN
cord-015684-q10sx1dm	591	150	APOE-4	APOE-4	NNP
cord-015684-q10sx1dm	591	151	carriers	carrier	NNS
cord-015684-q10sx1dm	591	152	;	;	,
cord-015684-q10sx1dm	591	153	(	(	-LRB-
cord-015684-q10sx1dm	591	154	xvii	xvii	NNP
cord-015684-q10sx1dm	591	155	)	)	-RRB-
cord-015684-q10sx1dm	591	156	aortic	aortic	JJ
cord-015684-q10sx1dm	591	157	and	and	CC
cord-015684-q10sx1dm	591	158	systemic	systemic	JJ
cord-015684-q10sx1dm	591	159	atherosclerosis	atherosclerosis	NN
cord-015684-q10sx1dm	591	160	is	be	VBZ
cord-015684-q10sx1dm	591	161	also	also	RB
cord-015684-q10sx1dm	591	162	more	more	RBR
cord-015684-q10sx1dm	591	163	frequent	frequent	JJ
cord-015684-q10sx1dm	591	164	in	in	IN
cord-015684-q10sx1dm	591	165	APOE-4	APOE-4	NNP
cord-015684-q10sx1dm	591	166	carriers	carrier	NNS
cord-015684-q10sx1dm	591	167	;	;	,
cord-015684-q10sx1dm	591	168	(	(	-LRB-
cord-015684-q10sx1dm	591	169	xviii	xviii	NNP
cord-015684-q10sx1dm	591	170	)	)	-RRB-
cord-015684-q10sx1dm	591	171	liver	liver	NN
cord-015684-q10sx1dm	591	172	metabolism	metabolism	NN
cord-015684-q10sx1dm	591	173	and	and	CC
cord-015684-q10sx1dm	591	174	transaminase	transaminase	NN
cord-015684-q10sx1dm	591	175	activity	activity	NN
cord-015684-q10sx1dm	591	176	also	also	RB
cord-015684-q10sx1dm	591	177	differ	differ	VBP
cord-015684-q10sx1dm	591	178	in	in	IN
cord-015684-q10sx1dm	591	179	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	591	180	with	with	IN
cord-015684-q10sx1dm	591	181	respect	respect	NN
cord-015684-q10sx1dm	591	182	to	to	IN
cord-015684-q10sx1dm	591	183	other	other	JJ
cord-015684-q10sx1dm	591	184	genotypes	genotype	NNS
cord-015684-q10sx1dm	591	185	;	;	,
cord-015684-q10sx1dm	591	186	(	(	-LRB-
cord-015684-q10sx1dm	591	187	xix	xix	NNP
cord-015684-q10sx1dm	591	188	)	)	-RRB-
cord-015684-q10sx1dm	591	189	blood	blood	NN
cord-015684-q10sx1dm	591	190	pressure	pressure	NN
cord-015684-q10sx1dm	591	191	(	(	-LRB-
cord-015684-q10sx1dm	591	192	hypertension	hypertension	NN
cord-015684-q10sx1dm	591	193	)	)	-RRB-
cord-015684-q10sx1dm	591	194	and	and	CC
cord-015684-q10sx1dm	591	195	other	other	JJ
cord-015684-q10sx1dm	591	196	cardiovascular	cardiovascular	JJ
cord-015684-q10sx1dm	591	197	risk	risk	NN
cord-015684-q10sx1dm	591	198	factors	factor	NNS
cord-015684-q10sx1dm	591	199	also	also	RB
cord-015684-q10sx1dm	591	200	accumulate	accumulate	VBP
cord-015684-q10sx1dm	591	201	in	in	IN
cord-015684-q10sx1dm	591	202	APOE-4	APOE-4	NNPS
cord-015684-q10sx1dm	591	203	;	;	:
cord-015684-q10sx1dm	591	204	and	and	CC
cord-015684-q10sx1dm	592	1	(	(	-LRB-
cord-015684-q10sx1dm	592	2	xx	xx	LS
cord-015684-q10sx1dm	592	3	)	)	-RRB-
cord-015684-q10sx1dm	592	4	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	592	5	are	be	VBP
cord-015684-q10sx1dm	592	6	the	the	DT
cord-015684-q10sx1dm	592	7	poorest	poor	JJS
cord-015684-q10sx1dm	592	8	responders	responder	NNS
cord-015684-q10sx1dm	592	9	to	to	IN
cord-015684-q10sx1dm	592	10	conventional	conventional	JJ
cord-015684-q10sx1dm	592	11	drugs	drug	NNS
cord-015684-q10sx1dm	592	12	(	(	-LRB-
cord-015684-q10sx1dm	592	13	Fig	fig	NN
cord-015684-q10sx1dm	592	14	.	.	.
cord-015684-q10sx1dm	592	15	 	 	_SP
cord-015684-q10sx1dm	592	16	40.11	40.11	CD
cord-015684-q10sx1dm	592	17	)	)	-RRB-
cord-015684-q10sx1dm	592	18	.	.	.
cord-015684-q10sx1dm	593	1	These	these	DT
cord-015684-q10sx1dm	593	2	20	20	CD
cord-015684-q10sx1dm	593	3	major	major	JJ
cord-015684-q10sx1dm	593	4	phenotypic	phenotypic	NN
cord-015684-q10sx1dm	593	5	features	feature	NNS
cord-015684-q10sx1dm	593	6	clearly	clearly	RB
cord-015684-q10sx1dm	593	7	illustrate	illustrate	VBP
cord-015684-q10sx1dm	593	8	the	the	DT
cord-015684-q10sx1dm	593	9	biological	biological	JJ
cord-015684-q10sx1dm	593	10	disadvantage	disadvantage	NN
cord-015684-q10sx1dm	593	11	of	of	IN
cord-015684-q10sx1dm	593	12	APOE-4	APOE-4	NNP
cord-015684-q10sx1dm	593	13	homozygotes	homozygote	NNS
cord-015684-q10sx1dm	593	14	and	and	CC
cord-015684-q10sx1dm	593	15	the	the	DT
cord-015684-q10sx1dm	593	16	potential	potential	JJ
cord-015684-q10sx1dm	593	17	consequences	consequence	NNS
cord-015684-q10sx1dm	593	18	that	that	WDT
cord-015684-q10sx1dm	593	19	these	these	DT
cord-015684-q10sx1dm	593	20	patients	patient	NNS
cord-015684-q10sx1dm	593	21	may	may	MD
cord-015684-q10sx1dm	593	22	experience	experience	VB
cord-015684-q10sx1dm	593	23	when	when	WRB
cord-015684-q10sx1dm	593	24	they	-PRON-	PRP
cord-015684-q10sx1dm	593	25	receive	receive	VBP
cord-015684-q10sx1dm	593	26	pharmacological	pharmacological	JJ
cord-015684-q10sx1dm	593	27	treatment	treatment	NN
cord-015684-q10sx1dm	593	28	.	.	.
cord-015684-q10sx1dm	594	1	2	2	LS
cord-015684-q10sx1dm	594	2	,	,	,
cord-015684-q10sx1dm	594	3	4	4	CD
cord-015684-q10sx1dm	594	4	,	,	,
cord-015684-q10sx1dm	594	5	8	8	CD
cord-015684-q10sx1dm	594	6	,	,	,
cord-015684-q10sx1dm	594	7	[	[	-LRB-
cord-015684-q10sx1dm	594	8	16	16	CD
cord-015684-q10sx1dm	594	9	]	]	-RRB-
cord-015684-q10sx1dm	594	10	[	[	-LRB-
cord-015684-q10sx1dm	594	11	17	17	CD
cord-015684-q10sx1dm	594	12	]	]	-RRB-
cord-015684-q10sx1dm	594	13	[	[	-LRB-
cord-015684-q10sx1dm	594	14	18	18	CD
cord-015684-q10sx1dm	594	15	]	]	-RRB-
cord-015684-q10sx1dm	594	16	[	[	-LRB-
cord-015684-q10sx1dm	594	17	19	19	CD
cord-015684-q10sx1dm	594	18	]	]	-RRB-
cord-015684-q10sx1dm	595	1	[	[	-LRB-
cord-015684-q10sx1dm	595	2	20	20	CD
cord-015684-q10sx1dm	595	3	]	]	-RRB-
cord-015684-q10sx1dm	595	4	[	[	-LRB-
cord-015684-q10sx1dm	595	5	21	21	CD
cord-015684-q10sx1dm	595	6	]	]	-RRB-
cord-015684-q10sx1dm	596	1	[	[	-LRB-
cord-015684-q10sx1dm	596	2	22	22	CD
cord-015684-q10sx1dm	596	3	]	]	-RRB-
cord-015684-q10sx1dm	596	4	62	62	CD
cord-015684-q10sx1dm	596	5	,	,	,
cord-015684-q10sx1dm	596	6	63	63	CD
cord-015684-q10sx1dm	596	7	,	,	,
cord-015684-q10sx1dm	596	8	[	[	-LRB-
cord-015684-q10sx1dm	596	9	74	74	CD
cord-015684-q10sx1dm	596	10	]	]	-RRB-
cord-015684-q10sx1dm	597	1	[	[	-LRB-
cord-015684-q10sx1dm	597	2	75	75	CD
cord-015684-q10sx1dm	597	3	]	]	-RRB-
cord-015684-q10sx1dm	597	4	[	[	-LRB-
cord-015684-q10sx1dm	597	5	76	76	CD
cord-015684-q10sx1dm	597	6	]	]	-RRB-
cord-015684-q10sx1dm	597	7	[	[	-LRB-
cord-015684-q10sx1dm	597	8	77	77	CD
cord-015684-q10sx1dm	597	9	]	]	-RRB-
cord-015684-q10sx1dm	597	10	109	109	CD
cord-015684-q10sx1dm	597	11	,	,	,
cord-015684-q10sx1dm	597	12	110	110	CD
cord-015684-q10sx1dm	597	13	Fig	fig	NN
cord-015684-q10sx1dm	597	14	.	.	.
cord-015684-q10sx1dm	598	1	40.11	40.11	CD
cord-015684-q10sx1dm	598	2	APOE	APOE	NNS
cord-015684-q10sx1dm	598	3	-	-	HYPH
cord-015684-q10sx1dm	598	4	related	relate	VBN
cord-015684-q10sx1dm	598	5	cognitive	cognitive	JJ
cord-015684-q10sx1dm	598	6	performance	performance	NN
cord-015684-q10sx1dm	598	7	in	in	IN
cord-015684-q10sx1dm	598	8	patients	patient	NNS
cord-015684-q10sx1dm	598	9	with	with	IN
cord-015684-q10sx1dm	598	10	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	598	11	's	's	POS
cord-015684-q10sx1dm	598	12	disease	disease	NN
cord-015684-q10sx1dm	598	13	treated	treat	VBN
cord-015684-q10sx1dm	598	14	with	with	IN
cord-015684-q10sx1dm	598	15	a	a	DT
cord-015684-q10sx1dm	598	16	combination	combination	NN
cord-015684-q10sx1dm	598	17	therapy	therapy	NN
cord-015684-q10sx1dm	598	18	for	for	IN
cord-015684-q10sx1dm	598	19	1	1	CD
cord-015684-q10sx1dm	598	20	year	year	NN
cord-015684-q10sx1dm	598	21	(	(	-LRB-
cord-015684-q10sx1dm	598	22	Adapted	adapt	VBN
cord-015684-q10sx1dm	598	23	from	from	IN
cord-015684-q10sx1dm	598	24	R.	R.	NNP
cord-015684-q10sx1dm	598	25	Cacabelos	Cacabelos	NNP
cord-015684-q10sx1dm	598	26	77	77	CD
cord-015684-q10sx1dm	598	27	,	,	,
cord-015684-q10sx1dm	598	28	109	109	CD
cord-015684-q10sx1dm	598	29	)	)	-RRB-
cord-015684-q10sx1dm	598	30	.	.	.
cord-015684-q10sx1dm	599	1	Patients	patient	NNS
cord-015684-q10sx1dm	599	2	received	receive	VBD
cord-015684-q10sx1dm	599	3	a	a	DT
cord-015684-q10sx1dm	599	4	combination	combination	NN
cord-015684-q10sx1dm	599	5	therapy	therapy	NN
cord-015684-q10sx1dm	599	6	for	for	IN
cord-015684-q10sx1dm	599	7	1	1	CD
cord-015684-q10sx1dm	599	8	year	year	NN
cord-015684-q10sx1dm	599	9	,	,	,
cord-015684-q10sx1dm	599	10	and	and	CC
cord-015684-q10sx1dm	599	11	cognitive	cognitive	JJ
cord-015684-q10sx1dm	599	12	function	function	NN
cord-015684-q10sx1dm	599	13	(	(	-LRB-
cord-015684-q10sx1dm	599	14	MMSE	MMSE	NNP
cord-015684-q10sx1dm	599	15	score	score	NN
cord-015684-q10sx1dm	599	16	)	)	-RRB-
cord-015684-q10sx1dm	599	17	was	be	VBD
cord-015684-q10sx1dm	599	18	assessed	assess	VBN
cord-015684-q10sx1dm	599	19	at	at	IN
cord-015684-q10sx1dm	599	20	baseline	baseline	NN
cord-015684-q10sx1dm	599	21	(	(	-LRB-
cord-015684-q10sx1dm	599	22	B	b	NN
cord-015684-q10sx1dm	599	23	)	)	-RRB-
cord-015684-q10sx1dm	599	24	and	and	CC
cord-015684-q10sx1dm	599	25	after	after	IN
cord-015684-q10sx1dm	599	26	1	1	CD
cord-015684-q10sx1dm	599	27	,	,	,
cord-015684-q10sx1dm	599	28	3	3	CD
cord-015684-q10sx1dm	599	29	,	,	,
cord-015684-q10sx1dm	599	30	6	6	CD
cord-015684-q10sx1dm	599	31	,	,	,
cord-015684-q10sx1dm	599	32	9	9	CD
cord-015684-q10sx1dm	599	33	,	,	,
cord-015684-q10sx1dm	599	34	and	and	CC
cord-015684-q10sx1dm	599	35	12	12	CD
cord-015684-q10sx1dm	599	36	months	month	NNS
cord-015684-q10sx1dm	599	37	of	of	IN
cord-015684-q10sx1dm	599	38	treatment	treatment	NN
cord-015684-q10sx1dm	599	39	.	.	.
cord-015684-q10sx1dm	600	1	Several	several	JJ
cord-015684-q10sx1dm	600	2	studies	study	NNS
cord-015684-q10sx1dm	600	3	indicate	indicate	VBP
cord-015684-q10sx1dm	600	4	that	that	IN
cord-015684-q10sx1dm	600	5	the	the	DT
cord-015684-q10sx1dm	600	6	presence	presence	NN
cord-015684-q10sx1dm	600	7	of	of	IN
cord-015684-q10sx1dm	600	8	the	the	DT
cord-015684-q10sx1dm	600	9	APOE-4	APOE-4	NNP
cord-015684-q10sx1dm	600	10	allele	allele	NN
cord-015684-q10sx1dm	600	11	differentially	differentially	RB
cord-015684-q10sx1dm	600	12	affects	affect	VBZ
cord-015684-q10sx1dm	600	13	the	the	DT
cord-015684-q10sx1dm	600	14	quality	quality	NN
cord-015684-q10sx1dm	600	15	and	and	CC
cord-015684-q10sx1dm	600	16	size	size	NN
cord-015684-q10sx1dm	600	17	of	of	IN
cord-015684-q10sx1dm	600	18	drug	drug	NN
cord-015684-q10sx1dm	600	19	responsiveness	responsiveness	NN
cord-015684-q10sx1dm	600	20	in	in	IN
cord-015684-q10sx1dm	600	21	AD	ad	NN
cord-015684-q10sx1dm	600	22	patients	patient	NNS
cord-015684-q10sx1dm	600	23	treated	treat	VBN
cord-015684-q10sx1dm	600	24	with	with	IN
cord-015684-q10sx1dm	600	25	cholinergic	cholinergic	JJ
cord-015684-q10sx1dm	600	26	enhancers	enhancer	NNS
cord-015684-q10sx1dm	600	27	,	,	,
cord-015684-q10sx1dm	600	28	neuroprotective	neuroprotective	JJ
cord-015684-q10sx1dm	600	29	compounds	compound	NNS
cord-015684-q10sx1dm	600	30	or	or	CC
cord-015684-q10sx1dm	600	31	combination	combination	NN
cord-015684-q10sx1dm	600	32	therapies	therapy	NNS
cord-015684-q10sx1dm	600	33	;	;	:
cord-015684-q10sx1dm	600	34	however	however	RB
cord-015684-q10sx1dm	600	35	,	,	,
cord-015684-q10sx1dm	600	36	controversial	controversial	JJ
cord-015684-q10sx1dm	600	37	results	result	NNS
cord-015684-q10sx1dm	600	38	are	be	VBP
cord-015684-q10sx1dm	600	39	frequently	frequently	RB
cord-015684-q10sx1dm	600	40	found	find	VBN
cord-015684-q10sx1dm	600	41	due	due	IN
cord-015684-q10sx1dm	600	42	to	to	IN
cord-015684-q10sx1dm	600	43	methodological	methodological	JJ
cord-015684-q10sx1dm	600	44	problems	problem	NNS
cord-015684-q10sx1dm	600	45	,	,	,
cord-015684-q10sx1dm	600	46	study	study	NN
cord-015684-q10sx1dm	600	47	design	design	NN
cord-015684-q10sx1dm	600	48	,	,	,
cord-015684-q10sx1dm	600	49	and	and	CC
cord-015684-q10sx1dm	600	50	patients	patient	NNS
cord-015684-q10sx1dm	600	51	recruitment	recruitment	NN
cord-015684-q10sx1dm	600	52	in	in	IN
cord-015684-q10sx1dm	600	53	clinical	clinical	JJ
cord-015684-q10sx1dm	600	54	trials	trial	NNS
cord-015684-q10sx1dm	600	55	.	.	.
cord-015684-q10sx1dm	601	1	From	from	IN
cord-015684-q10sx1dm	601	2	these	these	DT
cord-015684-q10sx1dm	601	3	studies	study	NNS
cord-015684-q10sx1dm	601	4	we	-PRON-	PRP
cord-015684-q10sx1dm	601	5	can	can	MD
cord-015684-q10sx1dm	601	6	conclude	conclude	VB
cord-015684-q10sx1dm	601	7	the	the	DT
cord-015684-q10sx1dm	601	8	following	follow	VBG
cord-015684-q10sx1dm	601	9	:	:	:
cord-015684-q10sx1dm	601	10	(	(	-LRB-
cord-015684-q10sx1dm	601	11	i	i	NN
cord-015684-q10sx1dm	601	12	)	)	-RRB-
cord-015684-q10sx1dm	601	13	Multifactorial	multifactorial	JJ
cord-015684-q10sx1dm	601	14	treatments	treatment	NNS
cord-015684-q10sx1dm	601	15	combining	combine	VBG
cord-015684-q10sx1dm	601	16	neuroprotectants	neuroprotectant	NNS
cord-015684-q10sx1dm	601	17	,	,	,
cord-015684-q10sx1dm	601	18	endogenous	endogenous	JJ
cord-015684-q10sx1dm	601	19	nucleotides	nucleotide	NNS
cord-015684-q10sx1dm	601	20	,	,	,
cord-015684-q10sx1dm	601	21	nootropic	nootropic	NN
cord-015684-q10sx1dm	601	22	agents	agent	NNS
cord-015684-q10sx1dm	601	23	,	,	,
cord-015684-q10sx1dm	601	24	vasoactive	vasoactive	JJ
cord-015684-q10sx1dm	601	25	substances	substance	NNS
cord-015684-q10sx1dm	601	26	,	,	,
cord-015684-q10sx1dm	601	27	cholinesterase	cholinesterase	NN
cord-015684-q10sx1dm	601	28	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	601	29	,	,	,
cord-015684-q10sx1dm	601	30	and	and	CC
cord-015684-q10sx1dm	601	31	NMDA	NMDA	NNP
cord-015684-q10sx1dm	601	32	antagonists	antagonist	NNS
cord-015684-q10sx1dm	601	33	associated	associate	VBN
cord-015684-q10sx1dm	601	34	with	with	IN
cord-015684-q10sx1dm	601	35	metabolic	metabolic	JJ
cord-015684-q10sx1dm	601	36	supplementation	supplementation	NN
cord-015684-q10sx1dm	601	37	on	on	IN
cord-015684-q10sx1dm	601	38	an	an	DT
cord-015684-q10sx1dm	601	39	individual	individual	JJ
cord-015684-q10sx1dm	601	40	basis	basis	NN
cord-015684-q10sx1dm	601	41	adapted	adapt	VBN
cord-015684-q10sx1dm	601	42	to	to	IN
cord-015684-q10sx1dm	601	43	the	the	DT
cord-015684-q10sx1dm	601	44	phenotype	phenotype	NN
cord-015684-q10sx1dm	601	45	of	of	IN
cord-015684-q10sx1dm	601	46	the	the	DT
cord-015684-q10sx1dm	601	47	patient	patient	NN
cord-015684-q10sx1dm	601	48	may	may	MD
cord-015684-q10sx1dm	601	49	be	be	VB
cord-015684-q10sx1dm	601	50	useful	useful	JJ
cord-015684-q10sx1dm	601	51	to	to	TO
cord-015684-q10sx1dm	601	52	improve	improve	VB
cord-015684-q10sx1dm	601	53	cognition	cognition	NN
cord-015684-q10sx1dm	601	54	and	and	CC
cord-015684-q10sx1dm	601	55	slow	slow	RB
cord-015684-q10sx1dm	601	56	-	-	HYPH
cord-015684-q10sx1dm	601	57	down	down	RP
cord-015684-q10sx1dm	601	58	disease	disease	NN
cord-015684-q10sx1dm	601	59	progression	progression	NN
cord-015684-q10sx1dm	601	60	in	in	IN
cord-015684-q10sx1dm	601	61	AD	ad	NN
cord-015684-q10sx1dm	601	62	.	.	.
cord-015684-q10sx1dm	602	1	(	(	-LRB-
cord-015684-q10sx1dm	602	2	ii	ii	NN
cord-015684-q10sx1dm	602	3	)	)	-RRB-
cord-015684-q10sx1dm	603	1	In	in	IN
cord-015684-q10sx1dm	603	2	our	-PRON-	PRP$
cord-015684-q10sx1dm	603	3	personal	personal	JJ
cord-015684-q10sx1dm	603	4	experience	experience	NN
cord-015684-q10sx1dm	603	5	the	the	DT
cord-015684-q10sx1dm	603	6	best	good	JJS
cord-015684-q10sx1dm	603	7	results	result	NNS
cord-015684-q10sx1dm	603	8	have	have	VBP
cord-015684-q10sx1dm	603	9	been	be	VBN
cord-015684-q10sx1dm	603	10	obtained	obtain	VBN
cord-015684-q10sx1dm	603	11	combining	combine	VBG
cord-015684-q10sx1dm	603	12	(	(	-LRB-
cord-015684-q10sx1dm	603	13	a	a	DT
cord-015684-q10sx1dm	603	14	)	)	-RRB-
cord-015684-q10sx1dm	603	15	CDP	CDP	NNP
cord-015684-q10sx1dm	603	16	-	-	HYPH
cord-015684-q10sx1dm	603	17	choline	choline	NN
cord-015684-q10sx1dm	603	18	with	with	IN
cord-015684-q10sx1dm	603	19	piracetam	piracetam	NNP
cord-015684-q10sx1dm	603	20	and	and	CC
cord-015684-q10sx1dm	603	21	metabolic	metabolic	JJ
cord-015684-q10sx1dm	603	22	supplementation	supplementation	NN
cord-015684-q10sx1dm	603	23	,	,	,
cord-015684-q10sx1dm	603	24	(	(	-LRB-
cord-015684-q10sx1dm	603	25	b	b	NN
cord-015684-q10sx1dm	603	26	)	)	-RRB-
cord-015684-q10sx1dm	603	27	CDP	CDP	NNP
cord-015684-q10sx1dm	603	28	-	-	HYPH
cord-015684-q10sx1dm	603	29	choline	choline	NN
cord-015684-q10sx1dm	603	30	with	with	IN
cord-015684-q10sx1dm	603	31	piracetam	piracetam	NNP
cord-015684-q10sx1dm	603	32	and	and	CC
cord-015684-q10sx1dm	603	33	anapsos	anapsos	NNP
cord-015684-q10sx1dm	603	34	,	,	,
cord-015684-q10sx1dm	603	35	(	(	-LRB-
cord-015684-q10sx1dm	603	36	c	c	NN
cord-015684-q10sx1dm	603	37	)	)	-RRB-
cord-015684-q10sx1dm	603	38	CDP	CDP	NNP
cord-015684-q10sx1dm	603	39	-	-	HYPH
cord-015684-q10sx1dm	603	40	choline	choline	NN
cord-015684-q10sx1dm	603	41	with	with	IN
cord-015684-q10sx1dm	603	42	piracetam	piracetam	NNP
cord-015684-q10sx1dm	603	43	and	and	CC
cord-015684-q10sx1dm	603	44	cholinesterase	cholinesterase	NN
cord-015684-q10sx1dm	603	45	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	603	46	(	(	-LRB-
cord-015684-q10sx1dm	603	47	donepezil	donepezil	NNP
cord-015684-q10sx1dm	603	48	,	,	,
cord-015684-q10sx1dm	603	49	rivastigmine	rivastigmine	NNP
cord-015684-q10sx1dm	603	50	)	)	-RRB-
cord-015684-q10sx1dm	603	51	,	,	.
cord-015684-q10sx1dm	604	1	(	(	-LRB-
cord-015684-q10sx1dm	604	2	d	d	LS
cord-015684-q10sx1dm	604	3	)	)	-RRB-
cord-015684-q10sx1dm	604	4	CDP	CDP	NNP
cord-015684-q10sx1dm	604	5	-	-	HYPH
cord-015684-q10sx1dm	604	6	choline	choline	NN
cord-015684-q10sx1dm	604	7	with	with	IN
cord-015684-q10sx1dm	604	8	memantine	memantine	NN
cord-015684-q10sx1dm	604	9	,	,	,
cord-015684-q10sx1dm	604	10	and	and	CC
cord-015684-q10sx1dm	604	11	(	(	-LRB-
cord-015684-q10sx1dm	604	12	e	e	LS
cord-015684-q10sx1dm	604	13	)	)	-RRB-
cord-015684-q10sx1dm	604	14	CDPcholine	CDPcholine	NNP
cord-015684-q10sx1dm	604	15	,	,	,
cord-015684-q10sx1dm	604	16	piracetam	piracetam	NNP
cord-015684-q10sx1dm	604	17	and	and	CC
cord-015684-q10sx1dm	604	18	nicergoline	nicergoline	NN
cord-015684-q10sx1dm	604	19	.	.	.
cord-015684-q10sx1dm	605	1	(	(	-LRB-
cord-015684-q10sx1dm	605	2	iii	iii	NN
cord-015684-q10sx1dm	605	3	)	)	-RRB-
cord-015684-q10sx1dm	606	1	Some	some	DT
cord-015684-q10sx1dm	606	2	of	of	IN
cord-015684-q10sx1dm	606	3	these	these	DT
cord-015684-q10sx1dm	606	4	combination	combination	NN
cord-015684-q10sx1dm	606	5	therapies	therapy	NNS
cord-015684-q10sx1dm	606	6	have	have	VBP
cord-015684-q10sx1dm	606	7	proven	prove	VBN
cord-015684-q10sx1dm	606	8	to	to	TO
cord-015684-q10sx1dm	606	9	be	be	VB
cord-015684-q10sx1dm	606	10	effective	effective	JJ
cord-015684-q10sx1dm	606	11	,	,	,
cord-015684-q10sx1dm	606	12	improving	improve	VBG
cord-015684-q10sx1dm	606	13	cognition	cognition	NN
cord-015684-q10sx1dm	606	14	during	during	IN
cord-015684-q10sx1dm	606	15	the	the	DT
cord-015684-q10sx1dm	606	16	fi	fi	NNP
cord-015684-q10sx1dm	606	17	rst	rst	NNP
cord-015684-q10sx1dm	606	18	9	9	CD
cord-015684-q10sx1dm	606	19	months	month	NNS
cord-015684-q10sx1dm	606	20	of	of	IN
cord-015684-q10sx1dm	606	21	treatment	treatment	NN
cord-015684-q10sx1dm	606	22	,	,	,
cord-015684-q10sx1dm	606	23	and	and	CC
cord-015684-q10sx1dm	606	24	not	not	RB
cord-015684-q10sx1dm	606	25	showing	show	VBG
cord-015684-q10sx1dm	606	26	apparent	apparent	JJ
cord-015684-q10sx1dm	606	27	side	side	NN
cord-015684-q10sx1dm	606	28	-	-	HYPH
cord-015684-q10sx1dm	606	29	effects	effect	NNS
cord-015684-q10sx1dm	606	30	.	.	.
cord-015684-q10sx1dm	607	1	(	(	-LRB-
cord-015684-q10sx1dm	607	2	iv	iv	LS
cord-015684-q10sx1dm	607	3	)	)	-RRB-
cord-015684-q10sx1dm	608	1	The	the	DT
cord-015684-q10sx1dm	608	2	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	608	3	response	response	NN
cord-015684-q10sx1dm	608	4	in	in	IN
cord-015684-q10sx1dm	608	5	AD	ad	NN
cord-015684-q10sx1dm	608	6	seems	seem	VBZ
cord-015684-q10sx1dm	608	7	to	to	TO
cord-015684-q10sx1dm	608	8	be	be	VB
cord-015684-q10sx1dm	608	9	genotypespecifi	genotypespecifi	NNP
cord-015684-q10sx1dm	608	10	c	c	NNP
cord-015684-q10sx1dm	608	11	under	under	IN
cord-015684-q10sx1dm	608	12	different	different	JJ
cord-015684-q10sx1dm	608	13	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	608	14	conditions	condition	NNS
cord-015684-q10sx1dm	608	15	.	.	.
cord-015684-q10sx1dm	609	1	(	(	-LRB-
cord-015684-q10sx1dm	609	2	v	v	NN
cord-015684-q10sx1dm	609	3	)	)	-RRB-
cord-015684-q10sx1dm	610	1	In	in	IN
cord-015684-q10sx1dm	610	2	monogenic	monogenic	NNP
cord-015684-q10sx1dm	610	3	-	-	HYPH
cord-015684-q10sx1dm	610	4	related	relate	VBN
cord-015684-q10sx1dm	610	5	studies	study	NNS
cord-015684-q10sx1dm	610	6	,	,	,
cord-015684-q10sx1dm	610	7	patients	patient	NNS
cord-015684-q10sx1dm	610	8	with	with	IN
cord-015684-q10sx1dm	610	9	the	the	DT
cord-015684-q10sx1dm	610	10	APOE-2/3	APOE-2/3	NNP
cord-015684-q10sx1dm	610	11	and	and	CC
cord-015684-q10sx1dm	610	12	APOE-3/4	APOE-3/4	NNP
cord-015684-q10sx1dm	610	13	genotypes	genotype	NNS
cord-015684-q10sx1dm	610	14	are	be	VBP
cord-015684-q10sx1dm	610	15	the	the	DT
cord-015684-q10sx1dm	610	16	best	good	JJS
cord-015684-q10sx1dm	610	17	responders	responder	NNS
cord-015684-q10sx1dm	610	18	,	,	,
cord-015684-q10sx1dm	610	19	and	and	CC
cord-015684-q10sx1dm	610	20	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	610	21	carriers	carrier	NNS
cord-015684-q10sx1dm	610	22	are	be	VBP
cord-015684-q10sx1dm	610	23	the	the	DT
cord-015684-q10sx1dm	610	24	worst	bad	JJS
cord-015684-q10sx1dm	610	25	responders	responder	NNS
cord-015684-q10sx1dm	610	26	(	(	-LRB-
cord-015684-q10sx1dm	610	27	Fig	Fig	NNP
cord-015684-q10sx1dm	610	28	.	.	.
cord-015684-q10sx1dm	610	29	40.11	40.11	CD
cord-015684-q10sx1dm	610	30	)	)	-RRB-
cord-015684-q10sx1dm	610	31	.	.	.
cord-015684-q10sx1dm	611	1	(	(	-LRB-
cord-015684-q10sx1dm	611	2	vi	vi	NNP
cord-015684-q10sx1dm	611	3	)	)	-RRB-
cord-015684-q10sx1dm	612	1	PS1-and	ps1-and	CD
cord-015684-q10sx1dm	612	2	PS2-related	ps2-related	JJ
cord-015684-q10sx1dm	612	3	genotypes	genotype	NNS
cord-015684-q10sx1dm	612	4	do	do	VBP
cord-015684-q10sx1dm	612	5	not	not	RB
cord-015684-q10sx1dm	612	6	appear	appear	VB
cord-015684-q10sx1dm	612	7	to	to	IN
cord-015684-q10sx1dm	612	8	infl	infl	NNP
cord-015684-q10sx1dm	612	9	uence	uence	NNP
cord-015684-q10sx1dm	612	10	the	the	DT
cord-015684-q10sx1dm	612	11	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	612	12	response	response	NN
cord-015684-q10sx1dm	612	13	in	in	IN
cord-015684-q10sx1dm	612	14	AD	ad	NN
cord-015684-q10sx1dm	612	15	as	as	IN
cord-015684-q10sx1dm	612	16	independent	independent	JJ
cord-015684-q10sx1dm	612	17	genomic	genomic	JJ
cord-015684-q10sx1dm	612	18	entities	entity	NNS
cord-015684-q10sx1dm	612	19	;	;	:
cord-015684-q10sx1dm	612	20	however	however	RB
cord-015684-q10sx1dm	612	21	,	,	,
cord-015684-q10sx1dm	612	22	APP	app	NN
cord-015684-q10sx1dm	612	23	,	,	,
cord-015684-q10sx1dm	612	24	PS1	PS1	NNP
cord-015684-q10sx1dm	612	25	,	,	,
cord-015684-q10sx1dm	612	26	and	and	CC
cord-015684-q10sx1dm	612	27	PS2	ps2	NN
cord-015684-q10sx1dm	612	28	mutations	mutation	NNS
cord-015684-q10sx1dm	612	29	may	may	MD
cord-015684-q10sx1dm	612	30	drastically	drastically	RB
cord-015684-q10sx1dm	612	31	modify	modify	VB
cord-015684-q10sx1dm	612	32	the	the	DT
cord-015684-q10sx1dm	612	33	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	612	34	response	response	NN
cord-015684-q10sx1dm	612	35	to	to	IN
cord-015684-q10sx1dm	612	36	conventional	conventional	JJ
cord-015684-q10sx1dm	612	37	drugs	drug	NNS
cord-015684-q10sx1dm	612	38	.	.	.
cord-015684-q10sx1dm	613	1	(	(	-LRB-
cord-015684-q10sx1dm	613	2	vii	vii	NN
cord-015684-q10sx1dm	613	3	)	)	-RRB-
cord-015684-q10sx1dm	614	1	In	in	IN
cord-015684-q10sx1dm	614	2	trigenic	trigenic	NNP
cord-015684-q10sx1dm	614	3	-	-	HYPH
cord-015684-q10sx1dm	614	4	related	relate	VBN
cord-015684-q10sx1dm	614	5	studies	study	NNS
cord-015684-q10sx1dm	614	6	the	the	DT
cord-015684-q10sx1dm	614	7	best	good	JJS
cord-015684-q10sx1dm	614	8	responders	responder	NNS
cord-015684-q10sx1dm	614	9	are	be	VBP
cord-015684-q10sx1dm	614	10	those	those	DT
cord-015684-q10sx1dm	614	11	patients	patient	NNS
cord-015684-q10sx1dm	614	12	carrying	carry	VBG
cord-015684-q10sx1dm	614	13	the	the	DT
cord-015684-q10sx1dm	614	14	331222-	331222-	NNP
cord-015684-q10sx1dm	614	15	,	,	,
cord-015684-q10sx1dm	614	16	341122-	341122-	NNP
cord-015684-q10sx1dm	614	17	,	,	,
cord-015684-q10sx1dm	614	18	341222-	341222-	NNP
cord-015684-q10sx1dm	614	19	,	,	,
cord-015684-q10sx1dm	614	20	and	and	CC
cord-015684-q10sx1dm	614	21	441112-genomic	441112-genomic	CD
cord-015684-q10sx1dm	614	22	clusters	cluster	NNS
cord-015684-q10sx1dm	614	23	.	.	.
cord-015684-q10sx1dm	615	1	(	(	-LRB-
cord-015684-q10sx1dm	615	2	viii	viii	NNP
cord-015684-q10sx1dm	615	3	)	)	-RRB-
cord-015684-q10sx1dm	616	1	A	a	DT
cord-015684-q10sx1dm	616	2	genetic	genetic	JJ
cord-015684-q10sx1dm	616	3	defect	defect	NN
cord-015684-q10sx1dm	616	4	in	in	IN
cord-015684-q10sx1dm	616	5	the	the	DT
cord-015684-q10sx1dm	616	6	exon	exon	NN
cord-015684-q10sx1dm	616	7	5	5	CD
cord-015684-q10sx1dm	616	8	of	of	IN
cord-015684-q10sx1dm	616	9	the	the	DT
cord-015684-q10sx1dm	616	10	PS2	PS2	NNP
cord-015684-q10sx1dm	616	11	gene	gene	NN
cord-015684-q10sx1dm	616	12	seems	seem	VBZ
cord-015684-q10sx1dm	616	13	to	to	TO
cord-015684-q10sx1dm	616	14	exert	exert	VB
cord-015684-q10sx1dm	616	15	a	a	DT
cord-015684-q10sx1dm	616	16	negative	negative	JJ
cord-015684-q10sx1dm	616	17	effect	effect	NN
cord-015684-q10sx1dm	616	18	on	on	IN
cord-015684-q10sx1dm	616	19	cognition	cognition	NN
cord-015684-q10sx1dm	616	20	conferring	confer	VBG
cord-015684-q10sx1dm	616	21	PS2	PS2	NNP
cord-015684-q10sx1dm	616	22	+	+	SYM
cord-015684-q10sx1dm	616	23	carriers	carrier	NNS
cord-015684-q10sx1dm	616	24	in	in	IN
cord-015684-q10sx1dm	616	25	trigenic	trigenic	NNP
cord-015684-q10sx1dm	616	26	clusters	cluster	NNS
cord-015684-q10sx1dm	616	27	the	the	DT
cord-015684-q10sx1dm	616	28	condition	condition	NN
cord-015684-q10sx1dm	616	29	of	of	IN
cord-015684-q10sx1dm	616	30	poor	poor	JJ
cord-015684-q10sx1dm	616	31	responders	responder	NNS
cord-015684-q10sx1dm	616	32	to	to	IN
cord-015684-q10sx1dm	616	33	combination	combination	NN
cord-015684-q10sx1dm	616	34	therapy	therapy	NN
cord-015684-q10sx1dm	616	35	.	.	.
cord-015684-q10sx1dm	617	1	(	(	-LRB-
cord-015684-q10sx1dm	617	2	ix	ix	NNP
cord-015684-q10sx1dm	617	3	)	)	-RRB-
cord-015684-q10sx1dm	618	1	The	the	DT
cord-015684-q10sx1dm	618	2	worst	bad	JJS
cord-015684-q10sx1dm	618	3	responders	responder	NNS
cord-015684-q10sx1dm	618	4	in	in	IN
cord-015684-q10sx1dm	618	5	all	all	DT
cord-015684-q10sx1dm	618	6	genomic	genomic	JJ
cord-015684-q10sx1dm	618	7	clusters	cluster	NNS
cord-015684-q10sx1dm	618	8	are	be	VBP
cord-015684-q10sx1dm	618	9	patients	patient	NNS
cord-015684-q10sx1dm	618	10	with	with	IN
cord-015684-q10sx1dm	618	11	the	the	DT
cord-015684-q10sx1dm	618	12	441122	441122	CD
cord-015684-q10sx1dm	618	13	+	+	CD
cord-015684-q10sx1dm	618	14	genotype	genotype	NN
cord-015684-q10sx1dm	618	15	.	.	.
cord-015684-q10sx1dm	619	1	(	(	-LRB-
cord-015684-q10sx1dm	619	2	x	x	LS
cord-015684-q10sx1dm	619	3	)	)	-RRB-
cord-015684-q10sx1dm	619	4	The	the	DT
cord-015684-q10sx1dm	619	5	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	619	6	genotype	genotype	NN
cord-015684-q10sx1dm	619	7	seems	seem	VBZ
cord-015684-q10sx1dm	619	8	to	to	TO
cord-015684-q10sx1dm	619	9	accelerate	accelerate	VB
cord-015684-q10sx1dm	619	10	neurodegeneration	neurodegeneration	NN
cord-015684-q10sx1dm	619	11	anticipating	anticipate	VBG
cord-015684-q10sx1dm	619	12	the	the	DT
cord-015684-q10sx1dm	619	13	onset	onset	NN
cord-015684-q10sx1dm	619	14	of	of	IN
cord-015684-q10sx1dm	619	15	the	the	DT
cord-015684-q10sx1dm	619	16	disease	disease	NN
cord-015684-q10sx1dm	619	17	by	by	IN
cord-015684-q10sx1dm	619	18	5	5	CD
cord-015684-q10sx1dm	619	19	-	-	SYM
cord-015684-q10sx1dm	619	20	10	10	CD
cord-015684-q10sx1dm	619	21	years	year	NNS
cord-015684-q10sx1dm	619	22	;	;	:
cord-015684-q10sx1dm	619	23	and	and	CC
cord-015684-q10sx1dm	619	24	,	,	,
cord-015684-q10sx1dm	619	25	in	in	IN
cord-015684-q10sx1dm	619	26	general	general	JJ
cord-015684-q10sx1dm	619	27	,	,	,
cord-015684-q10sx1dm	619	28	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	619	29	carriers	carrier	NNS
cord-015684-q10sx1dm	619	30	show	show	VBP
cord-015684-q10sx1dm	619	31	a	a	DT
cord-015684-q10sx1dm	619	32	faster	fast	JJR
cord-015684-q10sx1dm	619	33	disease	disease	NN
cord-015684-q10sx1dm	619	34	progression	progression	NN
cord-015684-q10sx1dm	619	35	and	and	CC
cord-015684-q10sx1dm	619	36	a	a	DT
cord-015684-q10sx1dm	619	37	poorer	poorer	RBR
cord-015684-q10sx1dm	619	38	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	619	39	response	response	NN
cord-015684-q10sx1dm	619	40	to	to	IN
cord-015684-q10sx1dm	619	41	all	all	DT
cord-015684-q10sx1dm	619	42	available	available	JJ
cord-015684-q10sx1dm	619	43	treatments	treatment	NNS
cord-015684-q10sx1dm	619	44	than	than	IN
cord-015684-q10sx1dm	619	45	any	any	DT
cord-015684-q10sx1dm	619	46	other	other	JJ
cord-015684-q10sx1dm	619	47	polymorphic	polymorphic	JJ
cord-015684-q10sx1dm	619	48	variant	variant	NN
cord-015684-q10sx1dm	619	49	.	.	.
cord-015684-q10sx1dm	620	1	(	(	-LRB-
cord-015684-q10sx1dm	620	2	xi	xi	NNP
cord-015684-q10sx1dm	620	3	)	)	-RRB-
cord-015684-q10sx1dm	621	1	Pharmacogenomic	Pharmacogenomic	NNP
cord-015684-q10sx1dm	621	2	studies	study	NNS
cord-015684-q10sx1dm	621	3	using	use	VBG
cord-015684-q10sx1dm	621	4	trigenic	trigenic	NNP
cord-015684-q10sx1dm	621	5	,	,	,
cord-015684-q10sx1dm	621	6	tetragenic	tetragenic	NNP
cord-015684-q10sx1dm	621	7	or	or	CC
cord-015684-q10sx1dm	621	8	polygenic	polygenic	JJ
cord-015684-q10sx1dm	621	9	clusters	cluster	NNS
cord-015684-q10sx1dm	621	10	as	as	IN
cord-015684-q10sx1dm	621	11	a	a	DT
cord-015684-q10sx1dm	621	12	harmonization	harmonization	NN
cord-015684-q10sx1dm	621	13	procedure	procedure	NN
cord-015684-q10sx1dm	621	14	to	to	TO
cord-015684-q10sx1dm	621	15	reduce	reduce	VB
cord-015684-q10sx1dm	621	16	genomic	genomic	JJ
cord-015684-q10sx1dm	621	17	heterogeneity	heterogeneity	NN
cord-015684-q10sx1dm	621	18	are	be	VBP
cord-015684-q10sx1dm	621	19	very	very	RB
cord-015684-q10sx1dm	621	20	useful	useful	JJ
cord-015684-q10sx1dm	621	21	to	to	TO
cord-015684-q10sx1dm	621	22	widen	widen	VB
cord-015684-q10sx1dm	621	23	the	the	DT
cord-015684-q10sx1dm	621	24	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	621	25	scope	scope	NN
cord-015684-q10sx1dm	621	26	of	of	IN
cord-015684-q10sx1dm	621	27	limited	limited	JJ
cord-015684-q10sx1dm	621	28	pharmacological	pharmacological	JJ
cord-015684-q10sx1dm	621	29	resources	resource	NNS
cord-015684-q10sx1dm	621	30	.	.	.
cord-015684-q10sx1dm	622	1	[	[	-LRB-
cord-015684-q10sx1dm	622	2	4	4	CD
cord-015684-q10sx1dm	622	3	]	]	-RRB-
cord-015684-q10sx1dm	622	4	[	[	-LRB-
cord-015684-q10sx1dm	622	5	5	5	CD
cord-015684-q10sx1dm	622	6	]	]	-RRB-
cord-015684-q10sx1dm	622	7	[	[	-LRB-
cord-015684-q10sx1dm	622	8	6	6	CD
cord-015684-q10sx1dm	622	9	]	]	-RRB-
cord-015684-q10sx1dm	622	10	[	[	-LRB-
cord-015684-q10sx1dm	622	11	16	16	CD
cord-015684-q10sx1dm	622	12	]	]	-RRB-
cord-015684-q10sx1dm	622	13	[	[	-LRB-
cord-015684-q10sx1dm	622	14	17	17	CD
cord-015684-q10sx1dm	622	15	]	]	-RRB-
cord-015684-q10sx1dm	622	16	[	[	-LRB-
cord-015684-q10sx1dm	622	17	18	18	CD
cord-015684-q10sx1dm	622	18	]	]	-RRB-
cord-015684-q10sx1dm	622	19	[	[	-LRB-
cord-015684-q10sx1dm	622	20	19	19	CD
cord-015684-q10sx1dm	622	21	]	]	-RRB-
cord-015684-q10sx1dm	622	22	[	[	-LRB-
cord-015684-q10sx1dm	622	23	20	20	CD
cord-015684-q10sx1dm	622	24	]	]	-RRB-
cord-015684-q10sx1dm	622	25	[	[	-LRB-
cord-015684-q10sx1dm	622	26	21	21	CD
cord-015684-q10sx1dm	622	27	]	]	-RRB-
cord-015684-q10sx1dm	622	28	[	[	-LRB-
cord-015684-q10sx1dm	622	29	22	22	CD
cord-015684-q10sx1dm	622	30	]	]	-RRB-
cord-015684-q10sx1dm	622	31	62	62	CD
cord-015684-q10sx1dm	622	32	,	,	,
cord-015684-q10sx1dm	622	33	63	63	CD
cord-015684-q10sx1dm	622	34	,	,	,
cord-015684-q10sx1dm	622	35	[	[	-LRB-
cord-015684-q10sx1dm	622	36	74	74	CD
cord-015684-q10sx1dm	622	37	]	]	-RRB-
cord-015684-q10sx1dm	622	38	[	[	-LRB-
cord-015684-q10sx1dm	622	39	75	75	CD
cord-015684-q10sx1dm	622	40	]	]	-RRB-
cord-015684-q10sx1dm	622	41	[	[	-LRB-
cord-015684-q10sx1dm	622	42	76	76	CD
cord-015684-q10sx1dm	622	43	]	]	-RRB-
cord-015684-q10sx1dm	622	44	[	[	-LRB-
cord-015684-q10sx1dm	622	45	77	77	CD
cord-015684-q10sx1dm	622	46	]	]	-RRB-
cord-015684-q10sx1dm	622	47	109	109	CD
cord-015684-q10sx1dm	622	48	,	,	,
cord-015684-q10sx1dm	622	49	110	110	CD
cord-015684-q10sx1dm	622	50	 	 	_SP
cord-015684-q10sx1dm	622	51	APOE	APOE	NNP
cord-015684-q10sx1dm	622	52	infl	infl	NN
cord-015684-q10sx1dm	622	53	uences	uence	NNS
cord-015684-q10sx1dm	622	54	liver	liver	NN
cord-015684-q10sx1dm	622	55	function	function	NN
cord-015684-q10sx1dm	622	56	and	and	CC
cord-015684-q10sx1dm	622	57	CYP2D6-related	cyp2d6-relate	VBN
cord-015684-q10sx1dm	622	58	enzymes	enzyme	NNS
cord-015684-q10sx1dm	622	59	probably	probably	RB
cord-015684-q10sx1dm	622	60	via	via	IN
cord-015684-q10sx1dm	622	61	regulation	regulation	NN
cord-015684-q10sx1dm	622	62	of	of	IN
cord-015684-q10sx1dm	622	63	hepatic	hepatic	JJ
cord-015684-q10sx1dm	622	64	lipid	lipid	NN
cord-015684-q10sx1dm	622	65	metabolism	metabolism	NN
cord-015684-q10sx1dm	622	66	.	.	.
cord-015684-q10sx1dm	623	1	20	20	CD
cord-015684-q10sx1dm	623	2	,	,	,
cord-015684-q10sx1dm	623	3	42	42	CD
cord-015684-q10sx1dm	623	4	,	,	,
cord-015684-q10sx1dm	623	5	[	[	-LRB-
cord-015684-q10sx1dm	623	6	74	74	CD
cord-015684-q10sx1dm	623	7	]	]	-RRB-
cord-015684-q10sx1dm	623	8	[	[	-LRB-
cord-015684-q10sx1dm	623	9	75	75	CD
cord-015684-q10sx1dm	623	10	]	]	-RRB-
cord-015684-q10sx1dm	623	11	[	[	-LRB-
cord-015684-q10sx1dm	623	12	76	76	CD
cord-015684-q10sx1dm	623	13	]	]	-RRB-
cord-015684-q10sx1dm	624	1	[	[	-LRB-
cord-015684-q10sx1dm	624	2	77	77	CD
cord-015684-q10sx1dm	624	3	]	]	-RRB-
cord-015684-q10sx1dm	625	1	It	-PRON-	PRP
cord-015684-q10sx1dm	625	2	has	have	VBZ
cord-015684-q10sx1dm	625	3	been	be	VBN
cord-015684-q10sx1dm	625	4	observed	observe	VBN
cord-015684-q10sx1dm	625	5	that	that	IN
cord-015684-q10sx1dm	625	6	APOE	APOE	NNP
cord-015684-q10sx1dm	625	7	may	may	MD
cord-015684-q10sx1dm	625	8	infl	infl	VB
cord-015684-q10sx1dm	625	9	uence	uence	NN
cord-015684-q10sx1dm	625	10	liver	liver	NN
cord-015684-q10sx1dm	625	11	function	function	NN
cord-015684-q10sx1dm	625	12	and	and	CC
cord-015684-q10sx1dm	625	13	drug	drug	NN
cord-015684-q10sx1dm	625	14	metabolism	metabolism	NN
cord-015684-q10sx1dm	625	15	by	by	IN
cord-015684-q10sx1dm	625	16	modifying	modify	VBG
cord-015684-q10sx1dm	625	17	hepatic	hepatic	JJ
cord-015684-q10sx1dm	625	18	steatosis	steatosis	NN
cord-015684-q10sx1dm	625	19	and	and	CC
cord-015684-q10sx1dm	625	20	transaminase	transaminase	NN
cord-015684-q10sx1dm	625	21	activity	activity	NN
cord-015684-q10sx1dm	625	22	.	.	.
cord-015684-q10sx1dm	626	1	There	there	EX
cord-015684-q10sx1dm	626	2	is	be	VBZ
cord-015684-q10sx1dm	626	3	a	a	DT
cord-015684-q10sx1dm	626	4	clear	clear	JJ
cord-015684-q10sx1dm	626	5	correlation	correlation	NN
cord-015684-q10sx1dm	626	6	between	between	IN
cord-015684-q10sx1dm	626	7	APOE	APOE	NNP
cord-015684-q10sx1dm	626	8	-	-	HYPH
cord-015684-q10sx1dm	626	9	related	relate	VBN
cord-015684-q10sx1dm	626	10	TG	TG	NNP
cord-015684-q10sx1dm	626	11	levels	level	NNS
cord-015684-q10sx1dm	626	12	and	and	CC
cord-015684-q10sx1dm	626	13	GOT	get	VBD
cord-015684-q10sx1dm	626	14	,	,	,
cord-015684-q10sx1dm	626	15	GPT	GPT	NNP
cord-015684-q10sx1dm	626	16	,	,	,
cord-015684-q10sx1dm	626	17	and	and	CC
cord-015684-q10sx1dm	626	18	GGT	GGT	NNP
cord-015684-q10sx1dm	626	19	activities	activity	NNS
cord-015684-q10sx1dm	626	20	in	in	IN
cord-015684-q10sx1dm	626	21	AD	ad	NN
cord-015684-q10sx1dm	626	22	.	.	.
cord-015684-q10sx1dm	627	1	20	20	CD
cord-015684-q10sx1dm	627	2	,	,	,
cord-015684-q10sx1dm	627	3	[	[	-LRB-
cord-015684-q10sx1dm	627	4	74	74	CD
cord-015684-q10sx1dm	627	5	]	]	-RRB-
cord-015684-q10sx1dm	627	6	[	[	-LRB-
cord-015684-q10sx1dm	627	7	75	75	CD
cord-015684-q10sx1dm	627	8	]	]	-RRB-
cord-015684-q10sx1dm	627	9	[	[	-LRB-
cord-015684-q10sx1dm	627	10	76	76	CD
cord-015684-q10sx1dm	627	11	]	]	-RRB-
cord-015684-q10sx1dm	627	12	[	[	-LRB-
cord-015684-q10sx1dm	627	13	77	77	CD
cord-015684-q10sx1dm	627	14	]	]	-RRB-
cord-015684-q10sx1dm	627	15	171	171	CD
cord-015684-q10sx1dm	628	1	Both	both	DT
cord-015684-q10sx1dm	628	2	plasma	plasma	NN
cord-015684-q10sx1dm	628	3	TG	tg	NN
cord-015684-q10sx1dm	628	4	levels	level	NNS
cord-015684-q10sx1dm	628	5	and	and	CC
cord-015684-q10sx1dm	628	6	transaminase	transaminase	NN
cord-015684-q10sx1dm	628	7	activity	activity	NN
cord-015684-q10sx1dm	628	8	are	be	VBP
cord-015684-q10sx1dm	628	9	signifi	signifi	NNP
cord-015684-q10sx1dm	628	10	cantly	cantly	RB
cord-015684-q10sx1dm	628	11	lower	low	JJR
cord-015684-q10sx1dm	628	12	in	in	IN
cord-015684-q10sx1dm	628	13	AD	ad	NN
cord-015684-q10sx1dm	628	14	patients	patient	NNS
cord-015684-q10sx1dm	628	15	harbouring	harbour	VBG
cord-015684-q10sx1dm	628	16	the	the	DT
cord-015684-q10sx1dm	628	17	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	628	18	genotype	genotype	NN
cord-015684-q10sx1dm	628	19	,	,	,
cord-015684-q10sx1dm	628	20	probably	probably	RB
cord-015684-q10sx1dm	628	21	indicating	indicate	VBG
cord-015684-q10sx1dm	628	22	(	(	-LRB-
cord-015684-q10sx1dm	628	23	a	a	LS
cord-015684-q10sx1dm	628	24	)	)	-RRB-
cord-015684-q10sx1dm	628	25	that	that	IN
cord-015684-q10sx1dm	628	26	low	low	JJ
cord-015684-q10sx1dm	628	27	TG	TG	NNP
cord-015684-q10sx1dm	628	28	levels	level	NNS
cord-015684-q10sx1dm	628	29	protect	protect	VBP
cord-015684-q10sx1dm	628	30	against	against	IN
cord-015684-q10sx1dm	628	31	liver	liver	NN
cord-015684-q10sx1dm	628	32	steatosis	steatosis	NN
cord-015684-q10sx1dm	628	33	,	,	,
cord-015684-q10sx1dm	628	34	and	and	CC
cord-015684-q10sx1dm	628	35	(	(	-LRB-
cord-015684-q10sx1dm	628	36	b	b	NN
cord-015684-q10sx1dm	628	37	)	)	-RRB-
cord-015684-q10sx1dm	628	38	that	that	IN
cord-015684-q10sx1dm	628	39	the	the	DT
cord-015684-q10sx1dm	628	40	presence	presence	NN
cord-015684-q10sx1dm	628	41	of	of	IN
cord-015684-q10sx1dm	628	42	the	the	DT
cord-015684-q10sx1dm	628	43	APOE-4	APOE-4	NNP
cord-015684-q10sx1dm	628	44	allele	allele	NN
cord-015684-q10sx1dm	628	45	infl	infl	XX
cord-015684-q10sx1dm	628	46	uences	uence	NNS
cord-015684-q10sx1dm	628	47	TG	TG	NNP
cord-015684-q10sx1dm	628	48	levels	level	NNS
cord-015684-q10sx1dm	628	49	,	,	,
cord-015684-q10sx1dm	628	50	liver	liver	NN
cord-015684-q10sx1dm	628	51	steatosis	steatosis	NN
cord-015684-q10sx1dm	628	52	,	,	,
cord-015684-q10sx1dm	628	53	and	and	CC
cord-015684-q10sx1dm	628	54	transaminase	transaminase	NN
cord-015684-q10sx1dm	628	55	activity	activity	NN
cord-015684-q10sx1dm	628	56	.	.	.
cord-015684-q10sx1dm	629	1	Consequently	consequently	RB
cord-015684-q10sx1dm	629	2	,	,	,
cord-015684-q10sx1dm	629	3	it	-PRON-	PRP
cord-015684-q10sx1dm	629	4	is	be	VBZ
cord-015684-q10sx1dm	629	5	very	very	RB
cord-015684-q10sx1dm	629	6	likely	likely	JJ
cord-015684-q10sx1dm	629	7	that	that	IN
cord-015684-q10sx1dm	629	8	APOE	APOE	NNP
cord-015684-q10sx1dm	629	9	infl	infl	XX
cord-015684-q10sx1dm	629	10	uences	uence	NNS
cord-015684-q10sx1dm	629	11	drug	drug	NN
cord-015684-q10sx1dm	629	12	metabolism	metabolism	NN
cord-015684-q10sx1dm	629	13	in	in	IN
cord-015684-q10sx1dm	629	14	the	the	DT
cord-015684-q10sx1dm	629	15	liver	liver	NN
cord-015684-q10sx1dm	629	16	through	through	IN
cord-015684-q10sx1dm	629	17	different	different	JJ
cord-015684-q10sx1dm	629	18	mechanisms	mechanism	NNS
cord-015684-q10sx1dm	629	19	,	,	,
cord-015684-q10sx1dm	629	20	including	include	VBG
cord-015684-q10sx1dm	629	21	interactions	interaction	NNS
cord-015684-q10sx1dm	629	22	with	with	IN
cord-015684-q10sx1dm	629	23	enzymes	enzyme	NNS
cord-015684-q10sx1dm	629	24	such	such	JJ
cord-015684-q10sx1dm	629	25	as	as	IN
cord-015684-q10sx1dm	629	26	transaminases	transaminase	NNS
cord-015684-q10sx1dm	630	1	and/	and/	CD
cord-015684-q10sx1dm	631	1	or	or	CC
cord-015684-q10sx1dm	631	2	cytochrome	cytochrome	VB
cord-015684-q10sx1dm	631	3	P450-related	p450-related	JJ
cord-015684-q10sx1dm	631	4	enzymes	enzyme	NNS
cord-015684-q10sx1dm	631	5	encoded	encode	VBN
cord-015684-q10sx1dm	631	6	in	in	IN
cord-015684-q10sx1dm	631	7	genes	gene	NNS
cord-015684-q10sx1dm	631	8	of	of	IN
cord-015684-q10sx1dm	631	9	the	the	DT
cord-015684-q10sx1dm	631	10	CYP	CYP	NNP
cord-015684-q10sx1dm	631	11	Superfamily	Superfamily	NNP
cord-015684-q10sx1dm	631	12	.	.	.
cord-015684-q10sx1dm	632	1	20	20	CD
cord-015684-q10sx1dm	632	2	,	,	,
cord-015684-q10sx1dm	632	3	[	[	-LRB-
cord-015684-q10sx1dm	632	4	74	74	CD
cord-015684-q10sx1dm	632	5	]	]	-RRB-
cord-015684-q10sx1dm	632	6	[	[	-LRB-
cord-015684-q10sx1dm	632	7	75	75	CD
cord-015684-q10sx1dm	632	8	]	]	-RRB-
cord-015684-q10sx1dm	632	9	[	[	-LRB-
cord-015684-q10sx1dm	632	10	76	76	CD
cord-015684-q10sx1dm	632	11	]	]	-RRB-
cord-015684-q10sx1dm	632	12	[	[	-LRB-
cord-015684-q10sx1dm	632	13	77	77	CD
cord-015684-q10sx1dm	632	14	]	]	-RRB-
cord-015684-q10sx1dm	632	15	109	109	CD
cord-015684-q10sx1dm	632	16	,	,	,
cord-015684-q10sx1dm	632	17	171	171	CD
cord-015684-q10sx1dm	632	18	When	when	WRB
cord-015684-q10sx1dm	632	19	APOE	APOE	NNP
cord-015684-q10sx1dm	632	20	and	and	CC
cord-015684-q10sx1dm	632	21	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	632	22	genotypes	genotype	NNS
cord-015684-q10sx1dm	632	23	are	be	VBP
cord-015684-q10sx1dm	632	24	integrated	integrate	VBN
cord-015684-q10sx1dm	632	25	in	in	IN
cord-015684-q10sx1dm	632	26	bigenic	bigenic	JJ
cord-015684-q10sx1dm	632	27	clusters	cluster	NNS
cord-015684-q10sx1dm	632	28	and	and	CC
cord-015684-q10sx1dm	632	29	the	the	DT
cord-015684-q10sx1dm	632	30	APOE	APOE	NNP
cord-015684-q10sx1dm	632	31	+	+	CC
cord-015684-q10sx1dm	633	1	CYP2D6-related	cyp2d6-related	JJ
cord-015684-q10sx1dm	633	2	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	633	3	response	response	NN
cord-015684-q10sx1dm	633	4	to	to	IN
cord-015684-q10sx1dm	633	5	a	a	DT
cord-015684-q10sx1dm	633	6	combination	combination	NN
cord-015684-q10sx1dm	633	7	therapy	therapy	NN
cord-015684-q10sx1dm	633	8	is	be	VBZ
cord-015684-q10sx1dm	633	9	analyzed	analyze	VBN
cord-015684-q10sx1dm	633	10	in	in	IN
cord-015684-q10sx1dm	633	11	AD	ad	NN
cord-015684-q10sx1dm	633	12	patients	patient	NNS
cord-015684-q10sx1dm	633	13	after	after	IN
cord-015684-q10sx1dm	633	14	1	1	CD
cord-015684-q10sx1dm	633	15	year	year	NN
cord-015684-q10sx1dm	633	16	of	of	IN
cord-015684-q10sx1dm	633	17	treatment	treatment	NN
cord-015684-q10sx1dm	633	18	,	,	,
cord-015684-q10sx1dm	633	19	it	-PRON-	PRP
cord-015684-q10sx1dm	633	20	becomes	become	VBZ
cord-015684-q10sx1dm	633	21	clear	clear	JJ
cord-015684-q10sx1dm	633	22	that	that	IN
cord-015684-q10sx1dm	633	23	the	the	DT
cord-015684-q10sx1dm	633	24	presence	presence	NN
cord-015684-q10sx1dm	633	25	of	of	IN
cord-015684-q10sx1dm	633	26	the	the	DT
cord-015684-q10sx1dm	633	27	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	633	28	genotype	genotype	NN
cord-015684-q10sx1dm	633	29	is	be	VBZ
cord-015684-q10sx1dm	633	30	able	able	JJ
cord-015684-q10sx1dm	633	31	to	to	TO
cord-015684-q10sx1dm	633	32	convert	convert	VB
cord-015684-q10sx1dm	633	33	pure	pure	JJ
cord-015684-q10sx1dm	633	34	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	633	35	*	*	NFP
cord-015684-q10sx1dm	633	36	1/	1/	CD
cord-015684-q10sx1dm	633	37	*	*	NFP
cord-015684-q10sx1dm	633	38	1	1	CD
cord-015684-q10sx1dm	633	39	EMs	em	NNS
cord-015684-q10sx1dm	633	40	into	into	IN
cord-015684-q10sx1dm	633	41	full	full	JJ
cord-015684-q10sx1dm	633	42	PMs	pm	NNS
cord-015684-q10sx1dm	633	43	(	(	-LRB-
cord-015684-q10sx1dm	633	44	Fig	Fig	NNP
cord-015684-q10sx1dm	633	45	.	.	.
cord-015684-q10sx1dm	633	46	40.12	40.12	CD
cord-015684-q10sx1dm	633	47	)	)	-RRB-
cord-015684-q10sx1dm	633	48	,	,	,
cord-015684-q10sx1dm	633	49	indicating	indicate	VBG
cord-015684-q10sx1dm	633	50	the	the	DT
cord-015684-q10sx1dm	633	51	existence	existence	NN
cord-015684-q10sx1dm	633	52	of	of	IN
cord-015684-q10sx1dm	633	53	a	a	DT
cord-015684-q10sx1dm	633	54	powerful	powerful	JJ
cord-015684-q10sx1dm	633	55	infl	infl	NN
cord-015684-q10sx1dm	633	56	uence	uence	NN
cord-015684-q10sx1dm	633	57	of	of	IN
cord-015684-q10sx1dm	633	58	the	the	DT
cord-015684-q10sx1dm	633	59	APOE-4	APOE-4	NNP
cord-015684-q10sx1dm	633	60	homozygous	homozygous	JJ
cord-015684-q10sx1dm	633	61	genotype	genotype	NN
cord-015684-q10sx1dm	633	62	on	on	IN
cord-015684-q10sx1dm	633	63	the	the	DT
cord-015684-q10sx1dm	633	64	drug	drug	NN
cord-015684-q10sx1dm	633	65	metabolizing	metabolize	VBG
cord-015684-q10sx1dm	633	66	capacity	capacity	NN
cord-015684-q10sx1dm	633	67	of	of	IN
cord-015684-q10sx1dm	633	68	pure	pure	JJ
cord-015684-q10sx1dm	633	69	CYP2D6-EMs	cyp2d6-ems	NN
cord-015684-q10sx1dm	633	70	.	.	.
cord-015684-q10sx1dm	633	71	20	20	CD
cord-015684-q10sx1dm	633	72	,	,	,
cord-015684-q10sx1dm	633	73	74	74	CD
cord-015684-q10sx1dm	633	74	,	,	,
cord-015684-q10sx1dm	633	75	75	75	CD
cord-015684-q10sx1dm	633	76	,	,	,
cord-015684-q10sx1dm	633	77	109	109	CD
cord-015684-q10sx1dm	633	78	 	 	_SP
cord-015684-q10sx1dm	633	79	Behavioral	behavioral	JJ
cord-015684-q10sx1dm	633	80	disturbances	disturbance	NNS
cord-015684-q10sx1dm	633	81	and	and	CC
cord-015684-q10sx1dm	633	82	mood	mood	NN
cord-015684-q10sx1dm	633	83	disorders	disorder	NNS
cord-015684-q10sx1dm	633	84	are	be	VBP
cord-015684-q10sx1dm	633	85	intrinsic	intrinsic	JJ
cord-015684-q10sx1dm	633	86	components	component	NNS
cord-015684-q10sx1dm	633	87	of	of	IN
cord-015684-q10sx1dm	633	88	dementia	dementia	NN
cord-015684-q10sx1dm	633	89	associated	associate	VBN
cord-015684-q10sx1dm	633	90	with	with	IN
cord-015684-q10sx1dm	633	91	memory	memory	NN
cord-015684-q10sx1dm	633	92	disorders	disorder	NNS
cord-015684-q10sx1dm	633	93	.	.	.
cord-015684-q10sx1dm	634	1	60	60	CD
cord-015684-q10sx1dm	634	2	,	,	,
cord-015684-q10sx1dm	634	3	[	[	-LRB-
cord-015684-q10sx1dm	634	4	172	172	CD
cord-015684-q10sx1dm	634	5	]	]	-RRB-
cord-015684-q10sx1dm	634	6	[	[	-LRB-
cord-015684-q10sx1dm	634	7	173	173	CD
cord-015684-q10sx1dm	634	8	]	]	-RRB-
cord-015684-q10sx1dm	634	9	[	[	-LRB-
cord-015684-q10sx1dm	634	10	174	174	CD
cord-015684-q10sx1dm	634	11	]	]	-RRB-
cord-015684-q10sx1dm	635	1	The	the	DT
cord-015684-q10sx1dm	635	2	appearance	appearance	NN
cord-015684-q10sx1dm	635	3	of	of	IN
cord-015684-q10sx1dm	635	4	anxiety	anxiety	NN
cord-015684-q10sx1dm	635	5	,	,	,
cord-015684-q10sx1dm	635	6	depression	depression	NN
cord-015684-q10sx1dm	635	7	,	,	,
cord-015684-q10sx1dm	635	8	psychotic	psychotic	JJ
cord-015684-q10sx1dm	635	9	symptoms	symptom	NNS
cord-015684-q10sx1dm	635	10	,	,	,
cord-015684-q10sx1dm	635	11	verbal	verbal	JJ
cord-015684-q10sx1dm	635	12	and	and	CC
cord-015684-q10sx1dm	635	13	physical	physical	JJ
cord-015684-q10sx1dm	635	14	aggressiveness	aggressiveness	NN
cord-015684-q10sx1dm	635	15	,	,	,
cord-015684-q10sx1dm	635	16	agitation	agitation	NN
cord-015684-q10sx1dm	635	17	,	,	,
cord-015684-q10sx1dm	635	18	wandering	wandering	NN
cord-015684-q10sx1dm	635	19	and	and	CC
cord-015684-q10sx1dm	635	20	sleep	sleep	NN
cord-015684-q10sx1dm	635	21	disorders	disorder	NNS
cord-015684-q10sx1dm	635	22	complicate	complicate	VBP
cord-015684-q10sx1dm	635	23	the	the	DT
cord-015684-q10sx1dm	635	24	clinical	clinical	JJ
cord-015684-q10sx1dm	635	25	picture	picture	NN
cord-015684-q10sx1dm	635	26	of	of	IN
cord-015684-q10sx1dm	635	27	dementia	dementia	NN
cord-015684-q10sx1dm	635	28	and	and	CC
cord-015684-q10sx1dm	635	29	add	add	VB
cord-015684-q10sx1dm	635	30	important	important	JJ
cord-015684-q10sx1dm	635	31	problems	problem	NNS
cord-015684-q10sx1dm	635	32	to	to	IN
cord-015684-q10sx1dm	635	33	the	the	DT
cord-015684-q10sx1dm	635	34	therapeutics	therapeutic	NNS
cord-015684-q10sx1dm	635	35	of	of	IN
cord-015684-q10sx1dm	635	36	AD	ad	NN
cord-015684-q10sx1dm	635	37	and	and	CC
cord-015684-q10sx1dm	635	38	the	the	DT
cord-015684-q10sx1dm	635	39	daily	daily	JJ
cord-015684-q10sx1dm	635	40	management	management	NN
cord-015684-q10sx1dm	635	41	of	of	IN
cord-015684-q10sx1dm	635	42	patients	patient	NNS
cord-015684-q10sx1dm	635	43	as	as	RB
cord-015684-q10sx1dm	635	44	well	well	RB
cord-015684-q10sx1dm	635	45	.	.	.
cord-015684-q10sx1dm	636	1	Under	under	IN
cord-015684-q10sx1dm	636	2	these	these	DT
cord-015684-q10sx1dm	636	3	conditions	condition	NNS
cord-015684-q10sx1dm	636	4	,	,	,
cord-015684-q10sx1dm	636	5	psychotropic	psychotropic	JJ
cord-015684-q10sx1dm	636	6	drugs	drug	NNS
cord-015684-q10sx1dm	636	7	(	(	-LRB-
cord-015684-q10sx1dm	636	8	antidepressants	antidepressant	NNS
cord-015684-q10sx1dm	636	9	,	,	,
cord-015684-q10sx1dm	636	10	anxyolitics	anxyolitic	NNS
cord-015684-q10sx1dm	636	11	,	,	,
cord-015684-q10sx1dm	636	12	hypnotics	hypnotic	NNS
cord-015684-q10sx1dm	636	13	,	,	,
cord-015684-q10sx1dm	636	14	and	and	CC
cord-015684-q10sx1dm	636	15	neuroleptics	neuroleptic	NNS
cord-015684-q10sx1dm	636	16	)	)	-RRB-
cord-015684-q10sx1dm	636	17	are	be	VBP
cord-015684-q10sx1dm	636	18	required	require	VBN
cord-015684-q10sx1dm	636	19	,	,	,
cord-015684-q10sx1dm	636	20	and	and	CC
cord-015684-q10sx1dm	636	21	most	most	JJS
cord-015684-q10sx1dm	636	22	of	of	IN
cord-015684-q10sx1dm	636	23	these	these	DT
cord-015684-q10sx1dm	636	24	substances	substance	NNS
cord-015684-q10sx1dm	636	25	contribute	contribute	VBP
cord-015684-q10sx1dm	636	26	to	to	TO
cord-015684-q10sx1dm	636	27	deteriorate	deteriorate	VB
cord-015684-q10sx1dm	636	28	cognition	cognition	NN
cord-015684-q10sx1dm	636	29	and	and	CC
cord-015684-q10sx1dm	636	30	psychomotor	psychomotor	NN
cord-015684-q10sx1dm	636	31	functions	function	NNS
cord-015684-q10sx1dm	636	32	.	.	.
cord-015684-q10sx1dm	637	1	APOE	APOE	NNP
cord-015684-q10sx1dm	637	2	-	-	HYPH
cord-015684-q10sx1dm	637	3	related	relate	VBN
cord-015684-q10sx1dm	637	4	polymorphic	polymorphic	JJ
cord-015684-q10sx1dm	637	5	variants	variant	NNS
cord-015684-q10sx1dm	637	6	have	have	VBP
cord-015684-q10sx1dm	637	7	been	be	VBN
cord-015684-q10sx1dm	637	8	associated	associate	VBN
cord-015684-q10sx1dm	637	9	with	with	IN
cord-015684-q10sx1dm	637	10	mood	mood	NN
cord-015684-q10sx1dm	637	11	disorders	disorder	NNS
cord-015684-q10sx1dm	637	12	175	175	CD
cord-015684-q10sx1dm	637	13	,	,	,
cord-015684-q10sx1dm	637	14	176	176	CD
cord-015684-q10sx1dm	637	15	and	and	CC
cord-015684-q10sx1dm	637	16	panic	panic	NN
cord-015684-q10sx1dm	637	17	disorder	disorder	NN
cord-015684-q10sx1dm	637	18	.	.	.
cord-015684-q10sx1dm	638	1	177	177	CD
cord-015684-q10sx1dm	638	2	Gender	gender	NN
cord-015684-q10sx1dm	638	3	,	,	,
cord-015684-q10sx1dm	638	4	age	age	NN
cord-015684-q10sx1dm	638	5	,	,	,
cord-015684-q10sx1dm	638	6	dementia	dementia	NN
cord-015684-q10sx1dm	638	7	severity	severity	NN
cord-015684-q10sx1dm	638	8	,	,	,
cord-015684-q10sx1dm	638	9	APOE-4	APOE-4	NNP
cord-015684-q10sx1dm	638	10	,	,	,
cord-015684-q10sx1dm	638	11	and	and	CC
cord-015684-q10sx1dm	638	12	general	general	JJ
cord-015684-q10sx1dm	638	13	medical	medical	JJ
cord-015684-q10sx1dm	638	14	health	health	NN
cord-015684-q10sx1dm	638	15	appear	appear	VBP
cord-015684-q10sx1dm	638	16	to	to	IN
cord-015684-q10sx1dm	638	17	infl	infl	NNP
cord-015684-q10sx1dm	638	18	uence	uence	NNP
cord-015684-q10sx1dm	638	19	the	the	DT
cord-015684-q10sx1dm	638	20	occurrence	occurrence	NN
cord-015684-q10sx1dm	638	21	of	of	IN
cord-015684-q10sx1dm	638	22	individual	individual	JJ
cord-015684-q10sx1dm	638	23	neuropsychiatric	neuropsychiatric	JJ
cord-015684-q10sx1dm	638	24	symptoms	symptom	NNS
cord-015684-q10sx1dm	638	25	in	in	IN
cord-015684-q10sx1dm	638	26	dementia	dementia	NN
cord-015684-q10sx1dm	638	27	,	,	,
cord-015684-q10sx1dm	638	28	and	and	CC
cord-015684-q10sx1dm	638	29	medical	medical	JJ
cord-015684-q10sx1dm	638	30	comorbidity	comorbidity	NN
cord-015684-q10sx1dm	638	31	increases	increase	VBZ
cord-015684-q10sx1dm	638	32	the	the	DT
cord-015684-q10sx1dm	638	33	risk	risk	NN
cord-015684-q10sx1dm	638	34	of	of	IN
cord-015684-q10sx1dm	638	35	agitation	agitation	NN
cord-015684-q10sx1dm	638	36	,	,	,
cord-015684-q10sx1dm	638	37	irritability	irritability	NN
cord-015684-q10sx1dm	638	38	,	,	,
cord-015684-q10sx1dm	638	39	disinhibition	disinhibition	NN
cord-015684-q10sx1dm	638	40	,	,	,
cord-015684-q10sx1dm	638	41	and	and	CC
cord-015684-q10sx1dm	638	42	aberrant	aberrant	JJ
cord-015684-q10sx1dm	638	43	motor	motor	NN
cord-015684-q10sx1dm	638	44	behavior	behavior	NN
cord-015684-q10sx1dm	638	45	.	.	.
cord-015684-q10sx1dm	639	1	178	178	CD
cord-015684-q10sx1dm	640	1	A	a	DT
cord-015684-q10sx1dm	640	2	positive	positive	JJ
cord-015684-q10sx1dm	640	3	association	association	NN
cord-015684-q10sx1dm	640	4	between	between	IN
cord-015684-q10sx1dm	640	5	APOE-4	APOE-4	NNPS
cord-015684-q10sx1dm	640	6	and	and	CC
cord-015684-q10sx1dm	640	7	neuropsychiatric	neuropsychiatric	JJ
cord-015684-q10sx1dm	640	8	symptoms	symptom	NNS
cord-015684-q10sx1dm	640	9	179	179	CD
cord-015684-q10sx1dm	640	10	and	and	CC
cord-015684-q10sx1dm	640	11	depressive	depressive	JJ
cord-015684-q10sx1dm	640	12	symptoms	symptom	NNS
cord-015684-q10sx1dm	640	13	in	in	IN
cord-015684-q10sx1dm	640	14	AD	ad	NN
cord-015684-q10sx1dm	640	15	has	have	VBZ
cord-015684-q10sx1dm	640	16	been	be	VBN
cord-015684-q10sx1dm	640	17	reported	report	VBN
cord-015684-q10sx1dm	640	18	,	,	,
cord-015684-q10sx1dm	640	19	180	180	CD
cord-015684-q10sx1dm	640	20	especially	especially	RB
cord-015684-q10sx1dm	640	21	in	in	IN
cord-015684-q10sx1dm	640	22	women	woman	NNS
cord-015684-q10sx1dm	640	23	.	.	.
cord-015684-q10sx1dm	641	1	181	181	CD
cord-015684-q10sx1dm	642	1	In	in	IN
cord-015684-q10sx1dm	642	2	other	other	JJ
cord-015684-q10sx1dm	642	3	studies	study	NNS
cord-015684-q10sx1dm	642	4	,	,	,
cord-015684-q10sx1dm	642	5	no	no	DT
cord-015684-q10sx1dm	642	6	association	association	NN
cord-015684-q10sx1dm	642	7	of	of	IN
cord-015684-q10sx1dm	642	8	APOE-4	APOE-4	NNP
cord-015684-q10sx1dm	642	9	with	with	IN
cord-015684-q10sx1dm	642	10	behavioral	behavioral	JJ
cord-015684-q10sx1dm	642	11	dyscontrol	dyscontrol	NN
cord-015684-q10sx1dm	642	12	(	(	-LRB-
cord-015684-q10sx1dm	642	13	euphoria	euphoria	NN
cord-015684-q10sx1dm	642	14	,	,	,
cord-015684-q10sx1dm	642	15	disinhibition	disinhibition	NN
cord-015684-q10sx1dm	642	16	,	,	,
cord-015684-q10sx1dm	642	17	aberrant	aberrant	JJ
cord-015684-q10sx1dm	642	18	motor	motor	NN
cord-015684-q10sx1dm	642	19	behavior	behavior	NN
cord-015684-q10sx1dm	642	20	,	,	,
cord-015684-q10sx1dm	642	21	and	and	CC
cord-015684-q10sx1dm	642	22	sleep	sleep	NN
cord-015684-q10sx1dm	642	23	and	and	CC
cord-015684-q10sx1dm	642	24	appetite	appetite	NN
cord-015684-q10sx1dm	642	25	disturbances	disturbance	NNS
cord-015684-q10sx1dm	642	26	)	)	-RRB-
cord-015684-q10sx1dm	642	27	,	,	,
cord-015684-q10sx1dm	642	28	psychosis	psychosis	NN
cord-015684-q10sx1dm	642	29	(	(	-LRB-
cord-015684-q10sx1dm	642	30	delusions	delusion	NNS
cord-015684-q10sx1dm	642	31	and	and	CC
cord-015684-q10sx1dm	642	32	hallucinations	hallucination	NNS
cord-015684-q10sx1dm	642	33	)	)	-RRB-
cord-015684-q10sx1dm	642	34	,	,	,
cord-015684-q10sx1dm	642	35	mood	mood	NN
cord-015684-q10sx1dm	642	36	(	(	-LRB-
cord-015684-q10sx1dm	642	37	depression	depression	NN
cord-015684-q10sx1dm	642	38	,	,	,
cord-015684-q10sx1dm	642	39	anxiety	anxiety	NN
cord-015684-q10sx1dm	642	40	,	,	,
cord-015684-q10sx1dm	642	41	and	and	CC
cord-015684-q10sx1dm	642	42	apathy	apathy	NN
cord-015684-q10sx1dm	642	43	)	)	-RRB-
cord-015684-q10sx1dm	642	44	,	,	,
cord-015684-q10sx1dm	642	45	and	and	CC
cord-015684-q10sx1dm	642	46	agitation	agitation	NN
cord-015684-q10sx1dm	642	47	(	(	-LRB-
cord-015684-q10sx1dm	642	48	aggression	aggression	NN
cord-015684-q10sx1dm	642	49	and	and	CC
cord-015684-q10sx1dm	642	50	irritability	irritability	NN
cord-015684-q10sx1dm	642	51	)	)	-RRB-
cord-015684-q10sx1dm	642	52	could	could	MD
cord-015684-q10sx1dm	642	53	be	be	VB
cord-015684-q10sx1dm	642	54	found	find	VBN
cord-015684-q10sx1dm	642	55	.	.	.
cord-015684-q10sx1dm	643	1	182	182	CD
cord-015684-q10sx1dm	644	1	Some	some	DT
cord-015684-q10sx1dm	644	2	authors	author	NNS
cord-015684-q10sx1dm	644	3	did	do	VBD
cord-015684-q10sx1dm	644	4	not	not	RB
cord-015684-q10sx1dm	644	5	fi	fi	NNP
cord-015684-q10sx1dm	644	6	nd	nd	NNP
cord-015684-q10sx1dm	644	7	association	association	NNP
cord-015684-q10sx1dm	644	8	of	of	IN
cord-015684-q10sx1dm	644	9	APOE-4	APOE-4	NNP
cord-015684-q10sx1dm	644	10	with	with	IN
cord-015684-q10sx1dm	644	11	major	major	JJ
cord-015684-q10sx1dm	644	12	depression	depression	NN
cord-015684-q10sx1dm	644	13	in	in	IN
cord-015684-q10sx1dm	644	14	AD	ad	NN
cord-015684-q10sx1dm	644	15	183	183	CD
cord-015684-q10sx1dm	644	16	,	,	,
cord-015684-q10sx1dm	644	17	184	184	CD
cord-015684-q10sx1dm	644	18	or	or	CC
cord-015684-q10sx1dm	644	19	in	in	IN
cord-015684-q10sx1dm	644	20	patients	patient	NNS
cord-015684-q10sx1dm	644	21	with	with	IN
cord-015684-q10sx1dm	644	22	major	major	JJ
cord-015684-q10sx1dm	644	23	depression	depression	NN
cord-015684-q10sx1dm	644	24	in	in	IN
cord-015684-q10sx1dm	644	25	a	a	DT
cord-015684-q10sx1dm	644	26	community	community	NN
cord-015684-q10sx1dm	644	27	of	of	IN
cord-015684-q10sx1dm	644	28	older	old	JJR
cord-015684-q10sx1dm	644	29	adults	adult	NNS
cord-015684-q10sx1dm	644	30	,	,	,
cord-015684-q10sx1dm	644	31	185	185	CD
cord-015684-q10sx1dm	644	32	but	but	CC
cord-015684-q10sx1dm	644	33	an	an	DT
cord-015684-q10sx1dm	644	34	apparent	apparent	JJ
cord-015684-q10sx1dm	644	35	protective	protective	JJ
cord-015684-q10sx1dm	644	36	effect	effect	NN
cord-015684-q10sx1dm	644	37	of	of	IN
cord-015684-q10sx1dm	644	38	APOE-2	apoe-2	NN
cord-015684-q10sx1dm	644	39	on	on	IN
cord-015684-q10sx1dm	644	40	depressive	depressive	JJ
cord-015684-q10sx1dm	644	41	symptoms	symptom	NNS
cord-015684-q10sx1dm	644	42	was	be	VBD
cord-015684-q10sx1dm	644	43	detected	detect	VBN
cord-015684-q10sx1dm	644	44	.	.	.
cord-015684-q10sx1dm	645	1	186	186	CD
cord-015684-q10sx1dm	645	2	Others	other	NNS
cord-015684-q10sx1dm	645	3	,	,	,
cord-015684-q10sx1dm	645	4	in	in	IN
cord-015684-q10sx1dm	645	5	contrast	contrast	NN
cord-015684-q10sx1dm	645	6	,	,	,
cord-015684-q10sx1dm	645	7	found	find	VBD
cord-015684-q10sx1dm	645	8	that	that	IN
cord-015684-q10sx1dm	645	9	APOE-4	APOE-4	NNP
cord-015684-q10sx1dm	645	10	was	be	VBD
cord-015684-q10sx1dm	645	11	associated	associate	VBN
cord-015684-q10sx1dm	645	12	with	with	IN
cord-015684-q10sx1dm	645	13	an	an	DT
cord-015684-q10sx1dm	645	14	earlier	early	JJR
cord-015684-q10sx1dm	645	15	age	age	NN
cord-015684-q10sx1dm	645	16	-	-	HYPH
cord-015684-q10sx1dm	645	17	of	of	IN
cord-015684-q10sx1dm	645	18	-	-	HYPH
cord-015684-q10sx1dm	645	19	onset	onset	NN
cord-015684-q10sx1dm	645	20	,	,	,
cord-015684-q10sx1dm	645	21	but	but	CC
cord-015684-q10sx1dm	645	22	not	not	RB
cord-015684-q10sx1dm	645	23	cognitive	cognitive	JJ
cord-015684-q10sx1dm	645	24	functioning	functioning	NN
cord-015684-q10sx1dm	645	25	,	,	,
cord-015684-q10sx1dm	645	26	in	in	IN
cord-015684-q10sx1dm	645	27	late	late	JJ
cord-015684-q10sx1dm	645	28	-	-	HYPH
cord-015684-q10sx1dm	645	29	life	life	NN
cord-015684-q10sx1dm	645	30	depression	depression	NN
cord-015684-q10sx1dm	645	31	.	.	.
cord-015684-q10sx1dm	646	1	187	187	CD
cord-015684-q10sx1dm	646	2	Apoe−/−	apoe−/−	CD
cord-015684-q10sx1dm	646	3	mice	mouse	NNS
cord-015684-q10sx1dm	646	4	without	without	IN
cord-015684-q10sx1dm	646	5	human	human	JJ
cord-015684-q10sx1dm	646	6	ApoE	ApoE	NNS
cord-015684-q10sx1dm	646	7	or	or	CC
cord-015684-q10sx1dm	646	8	with	with	IN
cord-015684-q10sx1dm	646	9	APOE-4	APOE-4	NNPS
cord-015684-q10sx1dm	646	10	,	,	,
cord-015684-q10sx1dm	646	11	but	but	CC
cord-015684-q10sx1dm	646	12	not	not	RB
cord-015684-q10sx1dm	646	13	APOE-3	APOE-3	NNP
cord-015684-q10sx1dm	646	14	,	,	,
cord-015684-q10sx1dm	646	15	show	show	VBP
cord-015684-q10sx1dm	646	16	increased	increase	VBN
cord-015684-q10sx1dm	646	17	measures	measure	NNS
cord-015684-q10sx1dm	646	18	of	of	IN
cord-015684-q10sx1dm	646	19	anxiety	anxiety	NN
cord-015684-q10sx1dm	646	20	.	.	.
cord-015684-q10sx1dm	647	1	188	188	CD
cord-015684-q10sx1dm	647	2	Differences	difference	NNS
cord-015684-q10sx1dm	647	3	in	in	IN
cord-015684-q10sx1dm	647	4	anxiety	anxiety	NN
cord-015684-q10sx1dm	647	5	-	-	HYPH
cord-015684-q10sx1dm	647	6	related	relate	VBN
cord-015684-q10sx1dm	647	7	behavior	behavior	NN
cord-015684-q10sx1dm	647	8	have	have	VBP
cord-015684-q10sx1dm	647	9	been	be	VBN
cord-015684-q10sx1dm	647	10	observed	observe	VBN
cord-015684-q10sx1dm	647	11	between	between	IN
cord-015684-q10sx1dm	647	12	APOE	APOE	NNP
cord-015684-q10sx1dm	647	13	-	-	HYPH
cord-015684-q10sx1dm	647	14	defi	defi	NNP
cord-015684-q10sx1dm	647	15	cient	cient	NNP
cord-015684-q10sx1dm	647	16	C57BL/6	C57BL/6	NNP
cord-015684-q10sx1dm	647	17	and	and	CC
cord-015684-q10sx1dm	647	18	wild	wild	JJ
cord-015684-q10sx1dm	647	19	type	type	NN
cord-015684-q10sx1dm	647	20	C57BL/6	C57BL/6	NNP
cord-015684-q10sx1dm	647	21	mice	mouse	NNS
cord-015684-q10sx1dm	647	22	,	,	,
cord-015684-q10sx1dm	647	23	suggesting	suggest	VBG
cord-015684-q10sx1dm	647	24	that	that	IN
cord-015684-q10sx1dm	647	25	APOE	APOE	NNP
cord-015684-q10sx1dm	647	26	variants	variant	NNS
cord-015684-q10sx1dm	647	27	may	may	MD
cord-015684-q10sx1dm	647	28	affect	affect	VB
cord-015684-q10sx1dm	647	29	emotional	emotional	JJ
cord-015684-q10sx1dm	647	30	state	state	NN
cord-015684-q10sx1dm	647	31	.	.	.
cord-015684-q10sx1dm	648	1	189	189	CD
cord-015684-q10sx1dm	649	1	Histamine	histamine	NN
cord-015684-q10sx1dm	649	2	H3	H3	NNP
cord-015684-q10sx1dm	649	3	autoreceptor	autoreceptor	NN
cord-015684-q10sx1dm	649	4	antagonists	antagonist	NNS
cord-015684-q10sx1dm	649	5	increase	increase	VBP
cord-015684-q10sx1dm	649	6	anxiety	anxiety	NN
cord-015684-q10sx1dm	649	7	measures	measure	NNS
cord-015684-q10sx1dm	649	8	in	in	IN
cord-015684-q10sx1dm	649	9	wildtype	wildtype	NN
cord-015684-q10sx1dm	649	10	,	,	,
cord-015684-q10sx1dm	649	11	but	but	CC
cord-015684-q10sx1dm	649	12	not	not	RB
cord-015684-q10sx1dm	649	13	ApoE−/−	apoe−/−	NN
cord-015684-q10sx1dm	649	14	,	,	,
cord-015684-q10sx1dm	649	15	mice	mouse	NNS
cord-015684-q10sx1dm	649	16	,	,	,
cord-015684-q10sx1dm	649	17	and	and	CC
cord-015684-q10sx1dm	649	18	ApoE	ApoE	NNP
cord-015684-q10sx1dm	649	19	defi	defi	NNP
cord-015684-q10sx1dm	649	20	cient	cient	NNP
cord-015684-q10sx1dm	649	21	mice	mouse	NNS
cord-015684-q10sx1dm	649	22	show	show	VBP
cord-015684-q10sx1dm	649	23	higher	high	JJR
cord-015684-q10sx1dm	649	24	sensitivity	sensitivity	NN
cord-015684-q10sx1dm	649	25	to	to	IN
cord-015684-q10sx1dm	649	26	the	the	DT
cord-015684-q10sx1dm	649	27	anxiety	anxiety	NN
cord-015684-q10sx1dm	649	28	-	-	HYPH
cord-015684-q10sx1dm	649	29	reducing	reduce	VBG
cord-015684-q10sx1dm	649	30	effects	effect	NNS
cord-015684-q10sx1dm	649	31	of	of	IN
cord-015684-q10sx1dm	649	32	the	the	DT
cord-015684-q10sx1dm	649	33	H1	H1	NNP
cord-015684-q10sx1dm	649	34	receptor	receptor	NN
cord-015684-q10sx1dm	649	35	antagonist	antagonist	NN
cord-015684-q10sx1dm	649	36	mepyramine	mepyramine	NN
cord-015684-q10sx1dm	649	37	than	than	IN
cord-015684-q10sx1dm	649	38	wildtype	wildtype	JJ
cord-015684-q10sx1dm	649	39	mice	mouse	NNS
cord-015684-q10sx1dm	649	40	,	,	,
cord-015684-q10sx1dm	649	41	suggesting	suggest	VBG
cord-015684-q10sx1dm	649	42	a	a	DT
cord-015684-q10sx1dm	649	43	role	role	NN
cord-015684-q10sx1dm	649	44	of	of	IN
cord-015684-q10sx1dm	649	45	H3-autoreceptormediated	H3-autoreceptormediated	NNPS
cord-015684-q10sx1dm	649	46	signaling	signal	VBG
cord-015684-q10sx1dm	649	47	in	in	IN
cord-015684-q10sx1dm	649	48	anxiety	anxiety	NN
cord-015684-q10sx1dm	649	49	-	-	HYPH
cord-015684-q10sx1dm	649	50	like	like	JJ
cord-015684-q10sx1dm	649	51	symptoms	symptom	NNS
cord-015684-q10sx1dm	649	52	in	in	IN
cord-015684-q10sx1dm	649	53	this	this	DT
cord-015684-q10sx1dm	649	54	AD	ad	NN
cord-015684-q10sx1dm	649	55	-	-	HYPH
cord-015684-q10sx1dm	649	56	related	relate	VBN
cord-015684-q10sx1dm	649	57	animal	animal	NN
cord-015684-q10sx1dm	649	58	model	model	NN
cord-015684-q10sx1dm	649	59	.	.	.
cord-015684-q10sx1dm	650	1	190	190	CD
cord-015684-q10sx1dm	651	1	In	in	IN
cord-015684-q10sx1dm	651	2	humans	human	NNS
cord-015684-q10sx1dm	651	3	,	,	,
cord-015684-q10sx1dm	651	4	APOE-4	APOE-4	NNP
cord-015684-q10sx1dm	651	5	carriers	carrier	NNS
cord-015684-q10sx1dm	651	6	with	with	IN
cord-015684-q10sx1dm	651	7	deep	deep	JJ
cord-015684-q10sx1dm	651	8	white	white	JJ
cord-015684-q10sx1dm	651	9	matter	matter	NN
cord-015684-q10sx1dm	651	10	hyperintensities	hyperintensities	NNP
cord-015684-q10sx1dm	651	11	in	in	IN
cord-015684-q10sx1dm	651	12	MRI	MRI	NNP
cord-015684-q10sx1dm	651	13	show	show	NN
cord-015684-q10sx1dm	651	14	association	association	NN
cord-015684-q10sx1dm	651	15	with	with	IN
cord-015684-q10sx1dm	651	16	depressive	depressive	JJ
cord-015684-q10sx1dm	651	17	symptoms	symptom	NNS
cord-015684-q10sx1dm	651	18	and	and	CC
cord-015684-q10sx1dm	651	19	vascular	vascular	JJ
cord-015684-q10sx1dm	651	20	depression	depression	NN
cord-015684-q10sx1dm	651	21	.	.	.
cord-015684-q10sx1dm	652	1	191	191	CD
cord-015684-q10sx1dm	652	2	.	.	.
cord-015684-q10sx1dm	653	1	Reduced	reduce	VBN
cord-015684-q10sx1dm	653	2	caudate	caudate	NN
cord-015684-q10sx1dm	653	3	nucleus	nucleus	NN
cord-015684-q10sx1dm	653	4	volumes	volume	NNS
cord-015684-q10sx1dm	653	5	and	and	CC
cord-015684-q10sx1dm	653	6	genetic	genetic	JJ
cord-015684-q10sx1dm	653	7	determinants	determinant	NNS
cord-015684-q10sx1dm	653	8	of	of	IN
cord-015684-q10sx1dm	653	9	homocysteine	homocysteine	NN
cord-015684-q10sx1dm	653	10	metabolism	metabolism	NN
cord-015684-q10sx1dm	653	11	accumulate	accumulate	VBP
cord-015684-q10sx1dm	653	12	in	in	IN
cord-015684-q10sx1dm	653	13	patients	patient	NNS
cord-015684-q10sx1dm	653	14	with	with	IN
cord-015684-q10sx1dm	653	15	psychomotor	psychomotor	NN
cord-015684-q10sx1dm	653	16	slowing	slow	VBG
cord-015684-q10sx1dm	653	17	and	and	CC
cord-015684-q10sx1dm	653	18	cognitive	cognitive	JJ
cord-015684-q10sx1dm	653	19	defi	defi	NNP
cord-015684-q10sx1dm	653	20	cits	cits	NNP
cord-015684-q10sx1dm	653	21	,	,	,
cord-015684-q10sx1dm	653	22	192	192	CD
cord-015684-q10sx1dm	653	23	and	and	CC
cord-015684-q10sx1dm	653	24	older	old	JJR
cord-015684-q10sx1dm	653	25	depressed	depressed	JJ
cord-015684-q10sx1dm	653	26	subjects	subject	NNS
cord-015684-q10sx1dm	653	27	have	have	VBP
cord-015684-q10sx1dm	653	28	persisting	persist	VBG
cord-015684-q10sx1dm	653	29	cognitive	cognitive	JJ
cord-015684-q10sx1dm	653	30	impairments	impairment	NNS
cord-015684-q10sx1dm	653	31	associated	associate	VBN
cord-015684-q10sx1dm	653	32	with	with	IN
cord-015684-q10sx1dm	653	33	hippocampal	hippocampal	JJ
cord-015684-q10sx1dm	653	34	volume	volume	NN
cord-015684-q10sx1dm	653	35	reduction	reduction	NN
cord-015684-q10sx1dm	653	36	.	.	.
cord-015684-q10sx1dm	654	1	193	193	CD
cord-015684-q10sx1dm	654	2	,	,	,
cord-015684-q10sx1dm	654	3	194	194	CD
cord-015684-q10sx1dm	654	4	Depressive	depressive	JJ
cord-015684-q10sx1dm	654	5	symptoms	symptom	NNS
cord-015684-q10sx1dm	654	6	are	be	VBP
cord-015684-q10sx1dm	654	7	also	also	RB
cord-015684-q10sx1dm	654	8	associated	associate	VBN
cord-015684-q10sx1dm	654	9	with	with	IN
cord-015684-q10sx1dm	654	10	stroke	stroke	NN
cord-015684-q10sx1dm	654	11	and	and	CC
cord-015684-q10sx1dm	654	12	atherogenic	atherogenic	JJ
cord-015684-q10sx1dm	654	13	lipid	lipid	NN
cord-015684-q10sx1dm	654	14	profi	profi	NNP
cord-015684-q10sx1dm	654	15	le	le	NNP
cord-015684-q10sx1dm	654	16	.	.	.
cord-015684-q10sx1dm	655	1	195	195	CD
cord-015684-q10sx1dm	656	1	Some	some	DT
cord-015684-q10sx1dm	656	2	multifactorial	multifactorial	JJ
cord-015684-q10sx1dm	656	3	treatments	treatment	NNS
cord-015684-q10sx1dm	656	4	addressing	address	VBG
cord-015684-q10sx1dm	656	5	neuroprotection	neuroprotection	NN
cord-015684-q10sx1dm	656	6	have	have	VBP
cord-015684-q10sx1dm	656	7	shown	show	VBN
cord-015684-q10sx1dm	656	8	to	to	TO
cord-015684-q10sx1dm	656	9	be	be	VB
cord-015684-q10sx1dm	656	10	effective	effective	JJ
cord-015684-q10sx1dm	656	11	in	in	IN
cord-015684-q10sx1dm	656	12	reducing	reduce	VBG
cord-015684-q10sx1dm	656	13	anxiety	anxiety	NN
cord-015684-q10sx1dm	656	14	progressively	progressively	RB
cord-015684-q10sx1dm	656	15	from	from	IN
cord-015684-q10sx1dm	656	16	the	the	DT
cord-015684-q10sx1dm	656	17	fi	fi	NNP
cord-015684-q10sx1dm	656	18	rst	rst	NN
cord-015684-q10sx1dm	656	19	month	month	NN
cord-015684-q10sx1dm	656	20	to	to	IN
cord-015684-q10sx1dm	656	21	the	the	DT
cord-015684-q10sx1dm	656	22	12	12	CD
cord-015684-q10sx1dm	656	23	month	month	NN
cord-015684-q10sx1dm	656	24	of	of	IN
cord-015684-q10sx1dm	656	25	treatment	treatment	NN
cord-015684-q10sx1dm	656	26	.	.	.
cord-015684-q10sx1dm	657	1	109	109	CD
cord-015684-q10sx1dm	658	1	The	the	DT
cord-015684-q10sx1dm	658	2	anxiety	anxiety	NN
cord-015684-q10sx1dm	658	3	rate	rate	NN
cord-015684-q10sx1dm	658	4	was	be	VBD
cord-015684-q10sx1dm	658	5	declining	decline	VBG
cord-015684-q10sx1dm	658	6	from	from	IN
cord-015684-q10sx1dm	658	7	a	a	DT
cord-015684-q10sx1dm	658	8	baseline	baseline	JJ
cord-015684-q10sx1dm	658	9	HRS	HRS	NNP
cord-015684-q10sx1dm	658	10	-	-	HYPH
cord-015684-q10sx1dm	658	11	A	a	DT
cord-015684-q10sx1dm	658	12	score	score	NN
cord-015684-q10sx1dm	658	13	of	of	IN
cord-015684-q10sx1dm	658	14	10.90	10.90	CD
cord-015684-q10sx1dm	658	15	±	±	CD
cord-015684-q10sx1dm	658	16	5.69	5.69	CD
cord-015684-q10sx1dm	658	17	to	to	IN
cord-015684-q10sx1dm	658	18	9.07	9.07	CD
cord-015684-q10sx1dm	658	19	±	±	CD
cord-015684-q10sx1dm	658	20	4.03	4.03	CD
cord-015684-q10sx1dm	658	21	(	(	-LRB-
cord-015684-q10sx1dm	658	22	p	p	NN
cord-015684-q10sx1dm	658	23	<	<	XX
cord-015684-q10sx1dm	658	24	0.0000000001	0.0000000001	CD
cord-015684-q10sx1dm	658	25	)	)	-RRB-
cord-015684-q10sx1dm	658	26	at	at	IN
cord-015684-q10sx1dm	658	27	1	1	CD
cord-015684-q10sx1dm	658	28	month	month	NN
cord-015684-q10sx1dm	658	29	,	,	,
cord-015684-q10sx1dm	658	30	9.01	9.01	CD
cord-015684-q10sx1dm	658	31	±	±	CD
cord-015684-q10sx1dm	658	32	4.38	4.38	CD
cord-015684-q10sx1dm	658	33	(	(	-LRB-
cord-015684-q10sx1dm	658	34	p	p	NN
cord-015684-q10sx1dm	658	35	<	<	XX
cord-015684-q10sx1dm	658	36	0.000006	0.000006	CD
cord-015684-q10sx1dm	658	37	)	)	-RRB-
cord-015684-q10sx1dm	658	38	at	at	IN
cord-015684-q10sx1dm	658	39	3	3	CD
cord-015684-q10sx1dm	658	40	months	month	NNS
cord-015684-q10sx1dm	658	41	,	,	,
cord-015684-q10sx1dm	658	42	8.90	8.90	CD
cord-015684-q10sx1dm	658	43	±	±	CD
cord-015684-q10sx1dm	658	44	4.47	4.47	CD
cord-015684-q10sx1dm	658	45	(	(	-LRB-
cord-015684-q10sx1dm	658	46	p	p	NN
cord-015684-q10sx1dm	658	47	<	<	XX
cord-015684-q10sx1dm	658	48	0.005	0.005	CD
cord-015684-q10sx1dm	658	49	)	)	-RRB-
cord-015684-q10sx1dm	658	50	at	at	IN
cord-015684-q10sx1dm	658	51	6	6	CD
cord-015684-q10sx1dm	658	52	months	month	NNS
cord-015684-q10sx1dm	658	53	,	,	,
cord-015684-q10sx1dm	658	54	7.98	7.98	CD
cord-015684-q10sx1dm	658	55	±	±	CD
cord-015684-q10sx1dm	658	56	3.72	3.72	CD
cord-015684-q10sx1dm	658	57	(	(	-LRB-
cord-015684-q10sx1dm	658	58	p	p	NN
cord-015684-q10sx1dm	658	59	<	<	XX
cord-015684-q10sx1dm	658	60	0.00002	0.00002	CD
cord-015684-q10sx1dm	658	61	)	)	-RRB-
cord-015684-q10sx1dm	658	62	at	at	IN
cord-015684-q10sx1dm	658	63	9	9	CD
cord-015684-q10sx1dm	658	64	months	month	NNS
cord-015684-q10sx1dm	658	65	,	,	,
cord-015684-q10sx1dm	658	66	and	and	CC
cord-015684-q10sx1dm	658	67	8.56	8.56	CD
cord-015684-q10sx1dm	658	68	±	±	CD
cord-015684-q10sx1dm	658	69	4.72	4.72	CD
cord-015684-q10sx1dm	658	70	(	(	-LRB-
cord-015684-q10sx1dm	658	71	p	p	NN
cord-015684-q10sx1dm	658	72	<	<	XX
cord-015684-q10sx1dm	658	73	0.01	0.01	CD
cord-015684-q10sx1dm	658	74	)	)	-RRB-
cord-015684-q10sx1dm	658	75	at	at	IN
cord-015684-q10sx1dm	658	76	12	12	CD
cord-015684-q10sx1dm	658	77	months	month	NNS
cord-015684-q10sx1dm	658	78	of	of	IN
cord-015684-q10sx1dm	658	79	treatment	treatment	NN
cord-015684-q10sx1dm	659	1	(	(	-LRB-
cord-015684-q10sx1dm	659	2	r	r	NN
cord-015684-q10sx1dm	660	1	=	=	NFP
cord-015684-q10sx1dm	660	2	−0.82	−0.82	NNP
cord-015684-q10sx1dm	660	3	,	,	,
cord-015684-q10sx1dm	660	4	a	a	DT
cord-015684-q10sx1dm	660	5	coef	coef	NN
cord-015684-q10sx1dm	660	6	.	.	.
cord-015684-q10sx1dm	660	7	:	:	:
cord-015684-q10sx1dm	661	1	10.57	10.57	CD
cord-015684-q10sx1dm	661	2	,	,	,
cord-015684-q10sx1dm	661	3	b	b	LS
cord-015684-q10sx1dm	661	4	coef	coef	NN
cord-015684-q10sx1dm	661	5	.	.	.
cord-015684-q10sx1dm	662	1	:	:	:
cord-015684-q10sx1dm	663	1	−0.43	−0.43	NNP
cord-015684-q10sx1dm	663	2	)	)	-RRB-
cord-015684-q10sx1dm	663	3	.	.	.
cord-015684-q10sx1dm	664	1	109	109	CD
cord-015684-q10sx1dm	664	2	Similar	similar	JJ
cord-015684-q10sx1dm	664	3	striking	striking	JJ
cord-015684-q10sx1dm	664	4	results	result	NNS
cord-015684-q10sx1dm	664	5	were	be	VBD
cord-015684-q10sx1dm	664	6	found	find	VBN
cord-015684-q10sx1dm	664	7	in	in	IN
cord-015684-q10sx1dm	664	8	depression	depression	NN
cord-015684-q10sx1dm	664	9	,	,	,
cord-015684-q10sx1dm	664	10	suggesting	suggest	VBG
cord-015684-q10sx1dm	664	11	that	that	IN
cord-015684-q10sx1dm	664	12	improvement	improvement	NN
cord-015684-q10sx1dm	664	13	in	in	IN
cord-015684-q10sx1dm	664	14	mood	mood	NN
cord-015684-q10sx1dm	664	15	conditions	condition	NNS
cord-015684-q10sx1dm	664	16	can	can	MD
cord-015684-q10sx1dm	664	17	contribute	contribute	VB
cord-015684-q10sx1dm	664	18	to	to	TO
cord-015684-q10sx1dm	664	19	stabilize	stabilize	VB
cord-015684-q10sx1dm	664	20	cognitive	cognitive	JJ
cord-015684-q10sx1dm	664	21	function	function	NN
cord-015684-q10sx1dm	664	22	or	or	CC
cord-015684-q10sx1dm	664	23	that	that	IN
cord-015684-q10sx1dm	664	24	neuroprotection	neuroprotection	NN
cord-015684-q10sx1dm	664	25	(	(	-LRB-
cord-015684-q10sx1dm	664	26	with	with	IN
cord-015684-q10sx1dm	664	27	the	the	DT
cord-015684-q10sx1dm	664	28	consequent	consequent	JJ
cord-015684-q10sx1dm	664	29	stabilization	stabilization	NN
cord-015684-q10sx1dm	664	30	or	or	CC
cord-015684-q10sx1dm	664	31	improvement	improvement	NN
cord-015684-q10sx1dm	664	32	in	in	IN
cord-015684-q10sx1dm	664	33	mental	mental	JJ
cord-015684-q10sx1dm	664	34	performance	performance	NN
cord-015684-q10sx1dm	664	35	)	)	-RRB-
cord-015684-q10sx1dm	664	36	can	can	MD
cord-015684-q10sx1dm	664	37	enhance	enhance	VB
cord-015684-q10sx1dm	664	38	emotional	emotional	JJ
cord-015684-q10sx1dm	664	39	equilibrium	equilibrium	NN
cord-015684-q10sx1dm	664	40	.	.	.
cord-015684-q10sx1dm	665	1	20	20	CD
cord-015684-q10sx1dm	665	2	,	,	,
cord-015684-q10sx1dm	665	3	74	74	CD
cord-015684-q10sx1dm	665	4	,	,	,
cord-015684-q10sx1dm	665	5	75	75	CD
cord-015684-q10sx1dm	665	6	,	,	,
cord-015684-q10sx1dm	665	7	109	109	CD
cord-015684-q10sx1dm	666	1	At	at	IN
cord-015684-q10sx1dm	666	2	baseline	baseline	NN
cord-015684-q10sx1dm	666	3	,	,	,
cord-015684-q10sx1dm	666	4	all	all	DT
cord-015684-q10sx1dm	666	5	APOE	APOE	NNP
cord-015684-q10sx1dm	666	6	variants	variant	NNS
cord-015684-q10sx1dm	666	7	showed	show	VBD
cord-015684-q10sx1dm	666	8	similar	similar	JJ
cord-015684-q10sx1dm	666	9	anxiety	anxiety	NN
cord-015684-q10sx1dm	666	10	and	and	CC
cord-015684-q10sx1dm	666	11	depression	depression	NN
cord-015684-q10sx1dm	666	12	rates	rate	NNS
cord-015684-q10sx1dm	666	13	,	,	,
cord-015684-q10sx1dm	666	14	except	except	IN
cord-015684-q10sx1dm	666	15	the	the	DT
cord-015684-q10sx1dm	666	16	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	666	17	carriers	carrier	NNS
cord-015684-q10sx1dm	666	18	who	who	WP
cord-015684-q10sx1dm	666	19	differed	differ	VBD
cord-015684-q10sx1dm	666	20	from	from	IN
cord-015684-q10sx1dm	666	21	the	the	DT
cord-015684-q10sx1dm	666	22	rest	rest	NN
cord-015684-q10sx1dm	666	23	in	in	IN
cord-015684-q10sx1dm	666	24	a	a	DT
cord-015684-q10sx1dm	666	25	signifi	signifi	NNP
cord-015684-q10sx1dm	666	26	cantly	cantly	RB
cord-015684-q10sx1dm	666	27	lower	low	JJR
cord-015684-q10sx1dm	666	28	rates	rate	NNS
cord-015684-q10sx1dm	666	29	of	of	IN
cord-015684-q10sx1dm	666	30	anxiety	anxiety	NN
cord-015684-q10sx1dm	666	31	and	and	CC
cord-015684-q10sx1dm	666	32	depression	depression	NN
cord-015684-q10sx1dm	666	33	(	(	-LRB-
cord-015684-q10sx1dm	666	34	Figs	Figs	NNP
cord-015684-q10sx1dm	666	35	.	.	.
cord-015684-q10sx1dm	666	36	40.13	40.13	CD
cord-015684-q10sx1dm	666	37	and	and	CC
cord-015684-q10sx1dm	666	38	40.14	40.14	CD
cord-015684-q10sx1dm	666	39	)	)	-RRB-
cord-015684-q10sx1dm	666	40	.	.	.
cord-015684-q10sx1dm	667	1	Remarkable	remarkable	JJ
cord-015684-q10sx1dm	667	2	changes	change	NNS
cord-015684-q10sx1dm	667	3	in	in	IN
cord-015684-q10sx1dm	667	4	anxiety	anxiety	NN
cord-015684-q10sx1dm	667	5	were	be	VBD
cord-015684-q10sx1dm	667	6	found	find	VBN
cord-015684-q10sx1dm	667	7	among	among	IN
cord-015684-q10sx1dm	667	8	different	different	JJ
cord-015684-q10sx1dm	667	9	APOE	APOE	NNP
cord-015684-q10sx1dm	667	10	genotypes	genotype	NNS
cord-015684-q10sx1dm	667	11	(	(	-LRB-
cord-015684-q10sx1dm	667	12	Fig	Fig	NNP
cord-015684-q10sx1dm	667	13	.	.	NNP
cord-015684-q10sx1dm	667	14	40.13	40.13	CD
cord-015684-q10sx1dm	667	15	)	)	-RRB-
cord-015684-q10sx1dm	667	16	.	.	.
cord-015684-q10sx1dm	668	1	Practically	practically	RB
cord-015684-q10sx1dm	668	2	,	,	,
cord-015684-q10sx1dm	668	3	all	all	DT
cord-015684-q10sx1dm	668	4	APOE	APOE	NNP
cord-015684-q10sx1dm	668	5	variants	variant	NNS
cord-015684-q10sx1dm	668	6	responded	respond	VBD
cord-015684-q10sx1dm	668	7	with	with	IN
cord-015684-q10sx1dm	668	8	a	a	DT
cord-015684-q10sx1dm	668	9	signifi	signifi	NN
cord-015684-q10sx1dm	668	10	ca	can	MD
cord-015684-q10sx1dm	668	11	nt	not	RB
cord-015684-q10sx1dm	668	12	diminution	diminution	NN
cord-015684-q10sx1dm	668	13	of	of	IN
cord-015684-q10sx1dm	668	14	anxiogenic	anxiogenic	JJ
cord-015684-q10sx1dm	668	15	symptoms	symptom	NNS
cord-015684-q10sx1dm	668	16	,	,	,
cord-015684-q10sx1dm	668	17	except	except	IN
cord-015684-q10sx1dm	668	18	patients	patient	NNS
cord-015684-q10sx1dm	668	19	with	with	IN
cord-015684-q10sx1dm	668	20	the	the	DT
cord-015684-q10sx1dm	668	21	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	668	22	genotype	genotype	NN
cord-015684-q10sx1dm	668	23	who	who	WP
cord-015684-q10sx1dm	668	24	only	only	RB
cord-015684-q10sx1dm	668	25	showed	show	VBD
cord-015684-q10sx1dm	668	26	a	a	DT
cord-015684-q10sx1dm	668	27	slight	slight	JJ
cord-015684-q10sx1dm	668	28	improvement	improvement	NN
cord-015684-q10sx1dm	668	29	.	.	.
cord-015684-q10sx1dm	669	1	The	the	DT
cord-015684-q10sx1dm	669	2	best	good	JJS
cord-015684-q10sx1dm	669	3	responders	responder	NNS
cord-015684-q10sx1dm	669	4	were	be	VBD
cord-015684-q10sx1dm	669	5	APOE-2/4	APOE-2/4	NNPS
cord-015684-q10sx1dm	670	1	>	>	XX
cord-015684-q10sx1dm	671	1	APOE-2/3	APOE-2/3	NNP
cord-015684-q10sx1dm	672	1	>	>	XX
cord-015684-q10sx1dm	673	1	APOE-3/3	APOE-3/3	NNP
cord-015684-q10sx1dm	674	1	>	>	XX
cord-015684-q10sx1dm	675	1	APOE-3/4	APOE-3/4	NNP
cord-015684-q10sx1dm	675	2	carriers	carrier	NNS
cord-015684-q10sx1dm	675	3	(	(	-LRB-
cord-015684-q10sx1dm	675	4	Fig	Fig	NNP
cord-015684-q10sx1dm	675	5	.	.	NNP
cord-015684-q10sx1dm	675	6	40.13	40.13	CD
cord-015684-q10sx1dm	675	7	)	)	-RRB-
cord-015684-q10sx1dm	675	8	.	.	.
cord-015684-q10sx1dm	676	1	The	the	DT
cord-015684-q10sx1dm	676	2	modest	modest	JJ
cord-015684-q10sx1dm	676	3	anxiolytic	anxiolytic	JJ
cord-015684-q10sx1dm	676	4	effect	effect	NN
cord-015684-q10sx1dm	676	5	seen	see	VBN
cord-015684-q10sx1dm	676	6	in	in	IN
cord-015684-q10sx1dm	676	7	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	676	8	patients	patient	NNS
cord-015684-q10sx1dm	676	9	might	may	MD
cord-015684-q10sx1dm	676	10	be	be	VB
cord-015684-q10sx1dm	676	11	due	due	JJ
cord-015684-q10sx1dm	676	12	to	to	IN
cord-015684-q10sx1dm	676	13	the	the	DT
cord-015684-q10sx1dm	676	14	very	very	RB
cord-015684-q10sx1dm	676	15	low	low	JJ
cord-015684-q10sx1dm	676	16	anxiety	anxiety	NN
cord-015684-q10sx1dm	676	17	rate	rate	NN
cord-015684-q10sx1dm	676	18	observed	observe	VBN
cord-015684-q10sx1dm	676	19	at	at	IN
cord-015684-q10sx1dm	676	20	baseline	baseline	NN
cord-015684-q10sx1dm	676	21	.	.	.
cord-015684-q10sx1dm	677	1	Concerning	concern	VBG
cord-015684-q10sx1dm	677	2	depression	depression	NN
cord-015684-q10sx1dm	677	3	,	,	,
cord-015684-q10sx1dm	677	4	all	all	DT
cord-015684-q10sx1dm	677	5	APOE	APOE	NNP
cord-015684-q10sx1dm	677	6	genotypes	genotype	NNS
cord-015684-q10sx1dm	677	7	improved	improve	VBD
cord-015684-q10sx1dm	677	8	their	-PRON-	PRP$
cord-015684-q10sx1dm	677	9	depressive	depressive	JJ
cord-015684-q10sx1dm	677	10	symptoms	symptom	NNS
cord-015684-q10sx1dm	677	11	with	with	IN
cord-015684-q10sx1dm	677	12	treatment	treatment	NN
cord-015684-q10sx1dm	677	13	except	except	IN
cord-015684-q10sx1dm	677	14	those	those	DT
cord-015684-q10sx1dm	677	15	with	with	IN
cord-015684-q10sx1dm	677	16	the	the	DT
cord-015684-q10sx1dm	677	17	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	677	18	genotype	genotype	NN
cord-015684-q10sx1dm	677	19	which	which	WDT
cord-015684-q10sx1dm	677	20	worsen	worsen	VBP
cord-015684-q10sx1dm	677	21	along	along	IN
cord-015684-q10sx1dm	677	22	the	the	DT
cord-015684-q10sx1dm	677	23	treatment	treatment	NN
cord-015684-q10sx1dm	677	24	period	period	NN
cord-015684-q10sx1dm	677	25	,	,	,
cord-015684-q10sx1dm	677	26	especially	especially	RB
cord-015684-q10sx1dm	677	27	after	after	IN
cord-015684-q10sx1dm	677	28	9	9	CD
cord-015684-q10sx1dm	677	29	months	month	NNS
cord-015684-q10sx1dm	677	30	(	(	-LRB-
cord-015684-q10sx1dm	677	31	Fig	fig	NN
cord-015684-q10sx1dm	677	32	.	.	.
cord-015684-q10sx1dm	677	33	 	 	_SP
cord-015684-q10sx1dm	678	1	40	40	CD
cord-015684-q10sx1dm	678	2	.14	.14	NFP
cord-015684-q10sx1dm	678	3	)	)	-RRB-
cord-015684-q10sx1dm	678	4	.	.	.
cord-015684-q10sx1dm	679	1	The	the	DT
cord-015684-q10sx1dm	679	2	best	good	JJS
cord-015684-q10sx1dm	679	3	responders	responder	NNS
cord-015684-q10sx1dm	679	4	were	be	VBD
cord-015684-q10sx1dm	679	5	patients	patient	NNS
cord-015684-q10sx1dm	679	6	with	with	IN
cord-015684-q10sx1dm	679	7	APOE-2/4	APOE-2/4	NNP
cord-015684-q10sx1dm	680	1	>	>	XX
cord-015684-q10sx1dm	681	1	APOE-2/3	APOE-2/3	NNP
cord-015684-q10sx1dm	682	1	>	>	XX
cord-015684-q10sx1dm	683	1	APOE-3/3	APOE-3/3	NNP
cord-015684-q10sx1dm	683	2	>	>	XX
cord-015684-q10sx1dm	683	3	APOE-3/4	APOE-3/4	NNP
cord-015684-q10sx1dm	683	4	,	,	,
cord-015684-q10sx1dm	683	5	and	and	CC
cord-015684-q10sx1dm	683	6	the	the	DT
cord-015684-q10sx1dm	683	7	worst	bad	JJS
cord-015684-q10sx1dm	683	8	responders	responder	NNS
cord-015684-q10sx1dm	683	9	were	be	VBD
cord-015684-q10sx1dm	683	10	patients	patient	NNS
cord-015684-q10sx1dm	683	11	harbouring	harbour	VBG
cord-015684-q10sx1dm	683	12	the	the	DT
cord-015684-q10sx1dm	683	13	APOE-4/4	APOE-4/4	NNP
cord-015684-q10sx1dm	683	14	genotype	genotype	NN
cord-015684-q10sx1dm	683	15	20,74,75,109	20,74,75,109	NNP
cord-015684-q10sx1dm	683	16	(	(	-LRB-
cord-015684-q10sx1dm	683	17	Fig	Fig	NNP
cord-015684-q10sx1dm	683	18	.	.	.
cord-015684-q10sx1dm	683	19	40.14	40.14	CD
cord-015684-q10sx1dm	683	20	)	)	-RRB-
cord-015684-q10sx1dm	683	21	.	.	.
cord-015684-q10sx1dm	683	22	 	 	_SP
cord-015684-q10sx1dm	684	1	The	the	DT
cord-015684-q10sx1dm	684	2	optimization	optimization	NN
cord-015684-q10sx1dm	684	3	of	of	IN
cord-015684-q10sx1dm	684	4	CNS	CNS	NNP
cord-015684-q10sx1dm	684	5	therapeutics	therapeutic	NNS
cord-015684-q10sx1dm	684	6	requires	require	VBZ
cord-015684-q10sx1dm	684	7	the	the	DT
cord-015684-q10sx1dm	684	8	establishment	establishment	NN
cord-015684-q10sx1dm	684	9	of	of	IN
cord-015684-q10sx1dm	684	10	new	new	JJ
cord-015684-q10sx1dm	684	11	postulates	postulate	NNS
cord-015684-q10sx1dm	684	12	regarding	regard	VBG
cord-015684-q10sx1dm	684	13	(	(	-LRB-
cord-015684-q10sx1dm	684	14	a	a	NN
cord-015684-q10sx1dm	684	15	)	)	-RRB-
cord-015684-q10sx1dm	685	1	the	the	DT
cord-015684-q10sx1dm	685	2	costs	cost	NNS
cord-015684-q10sx1dm	685	3	of	of	IN
cord-015684-q10sx1dm	685	4	medicines	medicine	NNS
cord-015684-q10sx1dm	685	5	,	,	,
cord-015684-q10sx1dm	685	6	(	(	-LRB-
cord-015684-q10sx1dm	685	7	b	b	LS
cord-015684-q10sx1dm	685	8	)	)	-RRB-
cord-015684-q10sx1dm	685	9	the	the	DT
cord-015684-q10sx1dm	685	10	assessment	assessment	NN
cord-015684-q10sx1dm	685	11	of	of	IN
cord-015684-q10sx1dm	685	12	protocols	protocol	NNS
cord-015684-q10sx1dm	685	13	for	for	IN
cord-015684-q10sx1dm	685	14	multifactorial	multifactorial	JJ
cord-015684-q10sx1dm	685	15	treatment	treatment	NN
cord-015684-q10sx1dm	685	16	in	in	IN
cord-015684-q10sx1dm	685	17	chronic	chronic	JJ
cord-015684-q10sx1dm	685	18	disorders	disorder	NNS
cord-015684-q10sx1dm	685	19	,	,	,
cord-015684-q10sx1dm	685	20	(	(	-LRB-
cord-015684-q10sx1dm	685	21	c	c	NN
cord-015684-q10sx1dm	685	22	)	)	-RRB-
cord-015684-q10sx1dm	685	23	the	the	DT
cord-015684-q10sx1dm	685	24	implementation	implementation	NN
cord-015684-q10sx1dm	685	25	of	of	IN
cord-015684-q10sx1dm	685	26	novel	novel	JJ
cord-015684-q10sx1dm	685	27	therapeutics	therapeutic	NNS
cord-015684-q10sx1dm	685	28	addressing	address	VBG
cord-015684-q10sx1dm	685	29	causative	causative	JJ
cord-015684-q10sx1dm	685	30	factors	factor	NNS
cord-015684-q10sx1dm	685	31	,	,	,
cord-015684-q10sx1dm	685	32	and	and	CC
cord-015684-q10sx1dm	685	33	(	(	-LRB-
cord-015684-q10sx1dm	685	34	d	d	LS
cord-015684-q10sx1dm	685	35	)	)	-RRB-
cord-015684-q10sx1dm	685	36	the	the	DT
cord-015684-q10sx1dm	685	37	setting	setting	NN
cord-015684-q10sx1dm	685	38	-	-	HYPH
cord-015684-q10sx1dm	685	39	up	up	NN
cord-015684-q10sx1dm	685	40	of	of	IN
cord-015684-q10sx1dm	685	41	pharmacogenetic/	pharmacogenetic/	CD
cord-015684-q10sx1dm	685	42	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	685	43	strategies	strategy	NNS
cord-015684-q10sx1dm	685	44	for	for	IN
cord-015684-q10sx1dm	685	45	drug	drug	NN
cord-015684-q10sx1dm	685	46	development	development	NN
cord-015684-q10sx1dm	685	47	.	.	.
cord-015684-q10sx1dm	686	1	20	20	CD
cord-015684-q10sx1dm	686	2	,	,	,
cord-015684-q10sx1dm	686	3	[	[	-LRB-
cord-015684-q10sx1dm	686	4	74	74	CD
cord-015684-q10sx1dm	686	5	]	]	-RRB-
cord-015684-q10sx1dm	686	6	[	[	-LRB-
cord-015684-q10sx1dm	686	7	75	75	CD
cord-015684-q10sx1dm	686	8	]	]	-RRB-
cord-015684-q10sx1dm	686	9	[	[	-LRB-
cord-015684-q10sx1dm	686	10	76	76	CD
cord-015684-q10sx1dm	686	11	]	]	-RRB-
cord-015684-q10sx1dm	686	12	[	[	-LRB-
cord-015684-q10sx1dm	686	13	77	77	CD
cord-015684-q10sx1dm	686	14	]	]	-RRB-
cord-015684-q10sx1dm	686	15	109	109	CD
cord-015684-q10sx1dm	687	1	The	the	DT
cord-015684-q10sx1dm	687	2	cost	cost	NN
cord-015684-q10sx1dm	687	3	of	of	IN
cord-015684-q10sx1dm	687	4	medicines	medicine	NNS
cord-015684-q10sx1dm	687	5	is	be	VBZ
cord-015684-q10sx1dm	687	6	a	a	DT
cord-015684-q10sx1dm	687	7	very	very	RB
cord-015684-q10sx1dm	687	8	important	important	JJ
cord-015684-q10sx1dm	687	9	issue	issue	NN
cord-015684-q10sx1dm	687	10	in	in	IN
cord-015684-q10sx1dm	687	11	many	many	JJ
cord-015684-q10sx1dm	687	12	countries	country	NNS
cord-015684-q10sx1dm	687	13	because	because	IN
cord-015684-q10sx1dm	687	14	of	of	IN
cord-015684-q10sx1dm	687	15	(	(	-LRB-
cord-015684-q10sx1dm	687	16	i	i	NN
cord-015684-q10sx1dm	687	17	)	)	-RRB-
cord-015684-q10sx1dm	688	1	the	the	DT
cord-015684-q10sx1dm	688	2	growing	growing	NN
cord-015684-q10sx1dm	688	3	of	of	IN
cord-015684-q10sx1dm	688	4	the	the	DT
cord-015684-q10sx1dm	688	5	aging	age	VBG
cord-015684-q10sx1dm	688	6	population	population	NN
cord-015684-q10sx1dm	688	7	(	(	-LRB-
cord-015684-q10sx1dm	688	8	>	>	NFP
cord-015684-q10sx1dm	688	9	5	5	CD
cord-015684-q10sx1dm	688	10	%	%	NN
cord-015684-q10sx1dm	688	11	disability	disability	NN
cord-015684-q10sx1dm	688	12	)	)	-RRB-
cord-015684-q10sx1dm	688	13	,	,	,
cord-015684-q10sx1dm	688	14	(	(	-LRB-
cord-015684-q10sx1dm	688	15	ii	ii	NN
cord-015684-q10sx1dm	688	16	)	)	-RRB-
cord-015684-q10sx1dm	688	17	neuropsychiatric	neuropsychiatric	JJ
cord-015684-q10sx1dm	688	18	and	and	CC
cord-015684-q10sx1dm	688	19	demented	demented	JJ
cord-015684-q10sx1dm	688	20	patients	patient	NNS
cord-015684-q10sx1dm	688	21	(	(	-LRB-
cord-015684-q10sx1dm	688	22	>	>	NFP
cord-015684-q10sx1dm	688	23	5	5	CD
cord-015684-q10sx1dm	688	24	%	%	NN
cord-015684-q10sx1dm	688	25	of	of	IN
cord-015684-q10sx1dm	688	26	the	the	DT
cord-015684-q10sx1dm	688	27	population	population	NN
cord-015684-q10sx1dm	688	28	)	)	-RRB-
cord-015684-q10sx1dm	688	29	belong	belong	VBP
cord-015684-q10sx1dm	688	30	to	to	IN
cord-015684-q10sx1dm	688	31	an	an	DT
cord-015684-q10sx1dm	688	32	unproductive	unproductive	JJ
cord-015684-q10sx1dm	688	33	sector	sector	NN
cord-015684-q10sx1dm	688	34	with	with	IN
cord-015684-q10sx1dm	688	35	low	low	JJ
cord-015684-q10sx1dm	688	36	income	income	NN
cord-015684-q10sx1dm	688	37	,	,	,
cord-015684-q10sx1dm	688	38	and	and	CC
cord-015684-q10sx1dm	688	39	(	(	-LRB-
cord-015684-q10sx1dm	688	40	iii	iii	NN
cord-015684-q10sx1dm	688	41	)	)	-RRB-
cord-015684-q10sx1dm	689	1	the	the	DT
cord-015684-q10sx1dm	689	2	high	high	JJ
cord-015684-q10sx1dm	689	3	cost	cost	NN
cord-015684-q10sx1dm	689	4	of	of	IN
cord-015684-q10sx1dm	689	5	health	health	NN
cord-015684-q10sx1dm	689	6	care	care	NN
cord-015684-q10sx1dm	689	7	systems	system	NNS
cord-015684-q10sx1dm	689	8	and	and	CC
cord-015684-q10sx1dm	689	9	new	new	JJ
cord-015684-q10sx1dm	689	10	health	health	NN
cord-015684-q10sx1dm	689	11	technologies	technology	NNS
cord-015684-q10sx1dm	689	12	in	in	IN
cord-015684-q10sx1dm	689	13	developed	develop	VBN
cord-015684-q10sx1dm	689	14	countries	country	NNS
cord-015684-q10sx1dm	689	15	.	.	.
cord-015684-q10sx1dm	690	1	Despite	despite	IN
cord-015684-q10sx1dm	690	2	the	the	DT
cord-015684-q10sx1dm	690	3	effort	effort	NN
cord-015684-q10sx1dm	690	4	of	of	IN
cord-015684-q10sx1dm	690	5	the	the	DT
cord-015684-q10sx1dm	690	6	pharmaceutical	pharmaceutical	JJ
cord-015684-q10sx1dm	690	7	industry	industry	NN
cord-015684-q10sx1dm	690	8	to	to	TO
cord-015684-q10sx1dm	690	9	demonstrate	demonstrate	VB
cord-015684-q10sx1dm	690	10	the	the	DT
cord-015684-q10sx1dm	690	11	benefi	benefi	NNP
cord-015684-q10sx1dm	690	12	ts	ts	NN
cord-015684-q10sx1dm	690	13	and	and	CC
cord-015684-q10sx1dm	690	14	cost	cost	NN
cord-015684-q10sx1dm	690	15	-	-	HYPH
cord-015684-q10sx1dm	690	16	effectiveness	effectiveness	NN
cord-015684-q10sx1dm	690	17	of	of	IN
cord-015684-q10sx1dm	690	18	available	available	JJ
cord-015684-q10sx1dm	690	19	drugs	drug	NNS
cord-015684-q10sx1dm	690	20	,	,	,
cord-015684-q10sx1dm	690	21	the	the	DT
cord-015684-q10sx1dm	690	22	general	general	JJ
cord-015684-q10sx1dm	690	23	impression	impression	NN
cord-015684-q10sx1dm	690	24	in	in	IN
cord-015684-q10sx1dm	690	25	the	the	DT
cord-015684-q10sx1dm	690	26	medical	medical	JJ
cord-015684-q10sx1dm	690	27	community	community	NN
cord-015684-q10sx1dm	690	28	and	and	CC
cord-015684-q10sx1dm	690	29	in	in	IN
cord-015684-q10sx1dm	690	30	some	some	DT
cord-015684-q10sx1dm	690	31	governments	government	NNS
cord-015684-q10sx1dm	690	32	is	be	VBZ
cord-015684-q10sx1dm	690	33	that	that	IN
cord-015684-q10sx1dm	690	34	some	some	DT
cord-015684-q10sx1dm	690	35	psychotropics	psychotropic	NNS
cord-015684-q10sx1dm	690	36	and	and	CC
cord-015684-q10sx1dm	690	37	most	most	RBS
cord-015684-q10sx1dm	690	38	anti	anti	JJ
cord-015684-q10sx1dm	690	39	-	-	JJ
cord-015684-q10sx1dm	690	40	dementia	dementia	JJ
cord-015684-q10sx1dm	690	41	drugs	drug	NNS
cord-015684-q10sx1dm	690	42	present	present	JJ
cord-015684-q10sx1dm	690	43	in	in	IN
cord-015684-q10sx1dm	690	44	the	the	DT
cord-015684-q10sx1dm	690	45	market	market	NN
cord-015684-q10sx1dm	690	46	are	be	VBP
cord-015684-q10sx1dm	690	47	not	not	RB
cord-015684-q10sx1dm	690	48	costeffective	costeffective	JJ
cord-015684-q10sx1dm	690	49	.	.	.
cord-015684-q10sx1dm	691	1	20	20	CD
cord-015684-q10sx1dm	691	2	,	,	,
cord-015684-q10sx1dm	691	3	[	[	-LRB-
cord-015684-q10sx1dm	691	4	74	74	CD
cord-015684-q10sx1dm	691	5	]	]	-RRB-
cord-015684-q10sx1dm	691	6	[	[	-LRB-
cord-015684-q10sx1dm	691	7	75	75	CD
cord-015684-q10sx1dm	691	8	]	]	-RRB-
cord-015684-q10sx1dm	691	9	[	[	-LRB-
cord-015684-q10sx1dm	691	10	76	76	CD
cord-015684-q10sx1dm	691	11	]	]	-RRB-
cord-015684-q10sx1dm	692	1	[	[	-LRB-
cord-015684-q10sx1dm	692	2	77	77	CD
cord-015684-q10sx1dm	692	3	]	]	-RRB-
cord-015684-q10sx1dm	692	4	109	109	CD
cord-015684-q10sx1dm	692	5	Conventional	conventional	JJ
cord-015684-q10sx1dm	692	6	drugs	drug	NNS
cord-015684-q10sx1dm	692	7	for	for	IN
cord-015684-q10sx1dm	692	8	neuropsychi	neuropsychi	NNP
cord-015684-q10sx1dm	692	9	-	-	HYPH
cord-015684-q10sx1dm	692	10	atric	atric	NNP
cord-015684-q10sx1dm	692	11	disorders	disorder	NNS
cord-015684-q10sx1dm	692	12	are	be	VBP
cord-015684-q10sx1dm	692	13	relatively	relatively	RB
cord-015684-q10sx1dm	692	14	simple	simple	JJ
cord-015684-q10sx1dm	692	15	compounds	compound	NNS
cord-015684-q10sx1dm	692	16	with	with	IN
cord-015684-q10sx1dm	692	17	unreasonable	unreasonable	JJ
cord-015684-q10sx1dm	692	18	prices	price	NNS
cord-015684-q10sx1dm	692	19	.	.	.
cord-015684-q10sx1dm	693	1	Some	some	DT
cord-015684-q10sx1dm	693	2	new	new	JJ
cord-015684-q10sx1dm	693	3	products	product	NNS
cord-015684-q10sx1dm	693	4	are	be	VBP
cord-015684-q10sx1dm	693	5	not	not	RB
cord-015684-q10sx1dm	693	6	superior	superior	JJ
cord-015684-q10sx1dm	693	7	to	to	IN
cord-015684-q10sx1dm	693	8	conventional	conventional	JJ
cord-015684-q10sx1dm	693	9	antidepressants	antidepressant	NNS
cord-015684-q10sx1dm	693	10	,	,	,
cord-015684-q10sx1dm	693	11	neuroleptics	neuroleptic	NNS
cord-015684-q10sx1dm	693	12	,	,	,
cord-015684-q10sx1dm	693	13	and	and	CC
cord-015684-q10sx1dm	693	14	anxiolytics	anxiolytic	NNS
cord-015684-q10sx1dm	693	15	.	.	.
cord-015684-q10sx1dm	694	1	There	there	EX
cord-015684-q10sx1dm	694	2	is	be	VBZ
cord-015684-q10sx1dm	694	3	an	an	DT
cord-015684-q10sx1dm	694	4	urgent	urgent	JJ
cord-015684-q10sx1dm	694	5	need	need	NN
cord-015684-q10sx1dm	694	6	to	to	TO
cord-015684-q10sx1dm	694	7	assess	assess	VB
cord-015684-q10sx1dm	694	8	the	the	DT
cord-015684-q10sx1dm	694	9	costs	cost	NNS
cord-015684-q10sx1dm	694	10	of	of	IN
cord-015684-q10sx1dm	694	11	new	new	JJ
cord-015684-q10sx1dm	694	12	trials	trial	NNS
cord-015684-q10sx1dm	694	13	with	with	IN
cord-015684-q10sx1dm	694	14	pharmacogenetics	pharmacogenetic	NNS
cord-015684-q10sx1dm	694	15	and	and	CC
cord-015684-q10sx1dm	694	16	pharmacogenomics	pharmacogenomic	NNS
cord-015684-q10sx1dm	694	17	strategies	strategy	NNS
cord-015684-q10sx1dm	694	18	,	,	,
cord-015684-q10sx1dm	694	19	and	and	CC
cord-015684-q10sx1dm	694	20	to	to	TO
cord-015684-q10sx1dm	694	21	implement	implement	VB
cord-015684-q10sx1dm	694	22	pharmacogenetic	pharmacogenetic	JJ
cord-015684-q10sx1dm	694	23	procedures	procedure	NNS
cord-015684-q10sx1dm	694	24	to	to	TO
cord-015684-q10sx1dm	694	25	predict	predict	VB
cord-015684-q10sx1dm	694	26	drug	drug	NN
cord-015684-q10sx1dm	694	27	-	-	HYPH
cord-015684-q10sx1dm	694	28	related	relate	VBN
cord-015684-q10sx1dm	694	29	adverse	adverse	JJ
cord-015684-q10sx1dm	694	30	events	event	NNS
cord-015684-q10sx1dm	694	31	.	.	.
cord-015684-q10sx1dm	695	1	20	20	CD
cord-015684-q10sx1dm	695	2	,	,	,
cord-015684-q10sx1dm	695	3	74	74	CD
cord-015684-q10sx1dm	695	4	,	,	,
cord-015684-q10sx1dm	695	5	75	75	CD
cord-015684-q10sx1dm	695	6	,	,	,
cord-015684-q10sx1dm	695	7	109	109	CD
cord-015684-q10sx1dm	695	8	Cost	cost	NN
cord-015684-q10sx1dm	695	9	-	-	HYPH
cord-015684-q10sx1dm	695	10	effectiveness	effectiveness	NN
cord-015684-q10sx1dm	695	11	analysis	analysis	NN
cord-015684-q10sx1dm	695	12	has	have	VBZ
cord-015684-q10sx1dm	695	13	been	be	VBN
cord-015684-q10sx1dm	695	14	the	the	DT
cord-015684-q10sx1dm	695	15	most	most	RBS
cord-015684-q10sx1dm	695	16	commonly	commonly	RB
cord-015684-q10sx1dm	695	17	applied	apply	VBN
cord-015684-q10sx1dm	695	18	framework	framework	NN
cord-015684-q10sx1dm	695	19	for	for	IN
cord-015684-q10sx1dm	695	20	evaluating	evaluate	VBG
cord-015684-q10sx1dm	695	21	pharmacogenetics	pharmacogenetic	NNS
cord-015684-q10sx1dm	695	22	.	.	.
cord-015684-q10sx1dm	696	1	Pharmacogenetic	pharmacogenetic	JJ
cord-015684-q10sx1dm	696	2	testing	testing	NN
cord-015684-q10sx1dm	696	3	is	be	VBZ
cord-015684-q10sx1dm	696	4	potentially	potentially	RB
cord-015684-q10sx1dm	696	5	relevant	relevant	JJ
cord-015684-q10sx1dm	696	6	to	to	IN
cord-015684-q10sx1dm	696	7	large	large	JJ
cord-015684-q10sx1dm	696	8	populations	population	NNS
cord-015684-q10sx1dm	696	9	that	that	WDT
cord-015684-q10sx1dm	696	10	incur	incur	VBP
cord-015684-q10sx1dm	696	11	in	in	IN
cord-015684-q10sx1dm	696	12	high	high	JJ
cord-015684-q10sx1dm	696	13	costs	cost	NNS
cord-015684-q10sx1dm	696	14	.	.	.
cord-015684-q10sx1dm	697	1	For	for	IN
cord-015684-q10sx1dm	697	2	instance	instance	NN
cord-015684-q10sx1dm	697	3	,	,	,
cord-015684-q10sx1dm	697	4	the	the	DT
cord-015684-q10sx1dm	697	5	most	most	RBS
cord-015684-q10sx1dm	697	6	commonly	commonly	RB
cord-015684-q10sx1dm	697	7	drugs	drug	NNS
cord-015684-q10sx1dm	697	8	metabolized	metabolize	VBN
cord-015684-q10sx1dm	697	9	by	by	IN
cord-015684-q10sx1dm	697	10	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	697	11	account	account	NN
cord-015684-q10sx1dm	697	12	for	for	IN
cord-015684-q10sx1dm	697	13	189	189	CD
cord-015684-q10sx1dm	697	14	million	million	CD
cord-015684-q10sx1dm	697	15	prescriptions	prescription	NNS
cord-015684-q10sx1dm	697	16	and	and	CC
cord-015684-q10sx1dm	697	17	US$	us$	$
cord-015684-q10sx1dm	697	18	12.8	12.8	CD
cord-015684-q10sx1dm	697	19	billion	billion	CD
cord-015684-q10sx1dm	697	20	annually	annually	RB
cord-015684-q10sx1dm	697	21	in	in	IN
cord-015684-q10sx1dm	697	22	expenditures	expenditure	NNS
cord-015684-q10sx1dm	697	23	in	in	IN
cord-015684-q10sx1dm	697	24	the	the	DT
cord-015684-q10sx1dm	697	25	US	US	NNP
cord-015684-q10sx1dm	697	26	,	,	,
cord-015684-q10sx1dm	697	27	which	which	WDT
cord-015684-q10sx1dm	697	28	represent	represent	VBP
cord-015684-q10sx1dm	697	29	5	5	CD
cord-015684-q10sx1dm	697	30	-	-	SYM
cord-015684-q10sx1dm	697	31	10	10	CD
cord-015684-q10sx1dm	697	32	%	%	NN
cord-015684-q10sx1dm	697	33	of	of	IN
cord-015684-q10sx1dm	697	34	total	total	JJ
cord-015684-q10sx1dm	697	35	utilization	utilization	NN
cord-015684-q10sx1dm	697	36	and	and	CC
cord-015684-q10sx1dm	697	37	expenditures	expenditure	NNS
cord-015684-q10sx1dm	697	38	for	for	IN
cord-015684-q10sx1dm	697	39	outpatient	outpatient	NN
cord-015684-q10sx1dm	697	40	prescription	prescription	NN
cord-015684-q10sx1dm	697	41	drugs	drug	NNS
cord-015684-q10sx1dm	697	42	.	.	.
cord-015684-q10sx1dm	698	1	196	196	CD
cord-015684-q10sx1dm	698	2	Pharmacogenomics	Pharmacogenomics	NNPS
cord-015684-q10sx1dm	698	3	offer	offer	VBP
cord-015684-q10sx1dm	698	4	great	great	JJ
cord-015684-q10sx1dm	698	5	potential	potential	NN
cord-015684-q10sx1dm	698	6	to	to	TO
cord-015684-q10sx1dm	698	7	improve	improve	VB
cord-015684-q10sx1dm	698	8	patients	patient	NNS
cord-015684-q10sx1dm	698	9	'	'	POS
cord-015684-q10sx1dm	698	10	health	health	NN
cord-015684-q10sx1dm	698	11	in	in	IN
cord-015684-q10sx1dm	698	12	a	a	DT
cord-015684-q10sx1dm	698	13	cost	cost	NN
cord-015684-q10sx1dm	698	14	-	-	HYPH
cord-015684-q10sx1dm	698	15	effective	effective	JJ
cord-015684-q10sx1dm	698	16	manner	manner	NN
cord-015684-q10sx1dm	698	17	;	;	:
cord-015684-q10sx1dm	698	18	however	however	RB
cord-015684-q10sx1dm	698	19	,	,	,
cord-015684-q10sx1dm	698	20	pharmacogenetics	pharmacogenetics	NNP
cord-015684-q10sx1dm	698	21	/	/	SYM
cord-015684-q10sx1dm	698	22	pharmacogenomics	pharmacogenomic	NNS
cord-015684-q10sx1dm	698	23	will	will	MD
cord-015684-q10sx1dm	698	24	not	not	RB
cord-015684-q10sx1dm	698	25	be	be	VB
cord-015684-q10sx1dm	698	26	applied	apply	VBN
cord-015684-q10sx1dm	698	27	to	to	IN
cord-015684-q10sx1dm	698	28	all	all	DT
cord-015684-q10sx1dm	698	29	drugs	drug	NNS
cord-015684-q10sx1dm	698	30	available	available	JJ
cord-015684-q10sx1dm	698	31	in	in	IN
cord-015684-q10sx1dm	698	32	the	the	DT
cord-015684-q10sx1dm	698	33	market	market	NN
cord-015684-q10sx1dm	698	34	,	,	,
cord-015684-q10sx1dm	698	35	and	and	CC
cord-015684-q10sx1dm	698	36	careful	careful	JJ
cord-015684-q10sx1dm	698	37	evaluations	evaluation	NNS
cord-015684-q10sx1dm	698	38	should	should	MD
cord-015684-q10sx1dm	698	39	be	be	VB
cord-015684-q10sx1dm	698	40	done	do	VBN
cord-015684-q10sx1dm	698	41	on	on	IN
cord-015684-q10sx1dm	698	42	a	a	DT
cord-015684-q10sx1dm	698	43	case	case	NN
cord-015684-q10sx1dm	698	44	-	-	HYPH
cord-015684-q10sx1dm	698	45	by	by	IN
cord-015684-q10sx1dm	698	46	-	-	HYPH
cord-015684-q10sx1dm	698	47	case	case	NN
cord-015684-q10sx1dm	698	48	basis	basis	NN
cord-015684-q10sx1dm	698	49	prior	prior	RB
cord-015684-q10sx1dm	698	50	to	to	IN
cord-015684-q10sx1dm	698	51	investing	invest	VBG
cord-015684-q10sx1dm	698	52	resources	resource	NNS
cord-015684-q10sx1dm	698	53	in	in	IN
cord-015684-q10sx1dm	698	54	R&D	r&d	NN
cord-015684-q10sx1dm	698	55	of	of	IN
cord-015684-q10sx1dm	698	56	pharmacogenomic	pharmacogenomic	NN
cord-015684-q10sx1dm	698	57	-	-	HYPH
cord-015684-q10sx1dm	698	58	based	base	VBN
cord-015684-q10sx1dm	698	59	therapeutics	therapeutic	NNS
cord-015684-q10sx1dm	698	60	and	and	CC
cord-015684-q10sx1dm	698	61	making	make	VBG
cord-015684-q10sx1dm	698	62	reimbursement	reimbursement	NN
cord-015684-q10sx1dm	698	63	decisions	decision	NNS
cord-015684-q10sx1dm	698	64	.	.	.
cord-015684-q10sx1dm	699	1	197	197	CD
cord-015684-q10sx1dm	700	1	In	in	IN
cord-015684-q10sx1dm	700	2	performing	perform	VBG
cord-015684-q10sx1dm	700	3	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	700	4	studies	study	NNS
cord-015684-q10sx1dm	700	5	in	in	IN
cord-015684-q10sx1dm	700	6	CNS	CNS	NNP
cord-015684-q10sx1dm	700	7	disorders	disorder	NNS
cord-015684-q10sx1dm	700	8	,	,	,
cord-015684-q10sx1dm	700	9	it	-PRON-	PRP
cord-015684-q10sx1dm	700	10	is	be	VBZ
cord-015684-q10sx1dm	700	11	necessary	necessary	JJ
cord-015684-q10sx1dm	700	12	to	to	TO
cord-015684-q10sx1dm	700	13	rethink	rethink	VB
cord-015684-q10sx1dm	700	14	the	the	DT
cord-015684-q10sx1dm	700	15	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	700	16	expectations	expectation	NNS
cord-015684-q10sx1dm	700	17	of	of	IN
cord-015684-q10sx1dm	700	18	novel	novel	JJ
cord-015684-q10sx1dm	700	19	drugs	drug	NNS
cord-015684-q10sx1dm	700	20	,	,	,
cord-015684-q10sx1dm	700	21	redesign	redesign	VB
cord-015684-q10sx1dm	700	22	the	the	DT
cord-015684-q10sx1dm	700	23	protocols	protocol	NNS
cord-015684-q10sx1dm	700	24	for	for	IN
cord-015684-q10sx1dm	700	25	drug	drug	NN
cord-015684-q10sx1dm	700	26	clinical	clinical	JJ
cord-015684-q10sx1dm	700	27	trials	trial	NNS
cord-015684-q10sx1dm	700	28	,	,	,
cord-015684-q10sx1dm	700	29	and	and	CC
cord-015684-q10sx1dm	700	30	incorporate	incorporate	VB
cord-015684-q10sx1dm	700	31	biological	biological	JJ
cord-015684-q10sx1dm	700	32	markers	marker	NNS
cord-015684-q10sx1dm	700	33	as	as	IN
cord-015684-q10sx1dm	700	34	assessable	assessable	JJ
cord-015684-q10sx1dm	700	35	parameters	parameter	NNS
cord-015684-q10sx1dm	700	36	of	of	IN
cord-015684-q10sx1dm	700	37	effi	effi	NNP
cord-015684-q10sx1dm	700	38	cacy	cacy	NNP
cord-015684-q10sx1dm	700	39	and	and	CC
cord-015684-q10sx1dm	700	40	prevention	prevention	NN
cord-015684-q10sx1dm	700	41	.	.	.
cord-015684-q10sx1dm	701	1	In	in	IN
cord-015684-q10sx1dm	701	2	addition	addition	NN
cord-015684-q10sx1dm	701	3	to	to	IN
cord-015684-q10sx1dm	701	4	the	the	DT
cord-015684-q10sx1dm	701	5	characterization	characterization	NN
cord-015684-q10sx1dm	701	6	of	of	IN
cord-015684-q10sx1dm	701	7	genomic	genomic	JJ
cord-015684-q10sx1dm	701	8	profi	profi	NNP
cord-015684-q10sx1dm	701	9	les	les	NNP
cord-015684-q10sx1dm	701	10	,	,	,
cord-015684-q10sx1dm	701	11	phenotypic	phenotypic	JJ
cord-015684-q10sx1dm	701	12	profi	profi	NNP
cord-015684-q10sx1dm	701	13	ling	ling	NNP
cord-015684-q10sx1dm	701	14	of	of	IN
cord-015684-q10sx1dm	701	15	responders	responder	NNS
cord-015684-q10sx1dm	701	16	and	and	CC
cord-015684-q10sx1dm	701	17	non	non	NNS
cord-015684-q10sx1dm	701	18	-	-	NNS
cord-015684-q10sx1dm	701	19	responders	responder	NNS
cord-015684-q10sx1dm	701	20	to	to	IN
cord-015684-q10sx1dm	701	21	conventional	conventional	JJ
cord-015684-q10sx1dm	701	22	drugs	drug	NNS
cord-015684-q10sx1dm	701	23	is	be	VBZ
cord-015684-q10sx1dm	701	24	also	also	RB
cord-015684-q10sx1dm	701	25	important	important	JJ
cord-015684-q10sx1dm	701	26	(	(	-LRB-
cord-015684-q10sx1dm	701	27	and	and	CC
cord-015684-q10sx1dm	701	28	currently	currently	RB
cord-015684-q10sx1dm	701	29	neglected	neglect	VBN
cord-015684-q10sx1dm	701	30	)	)	-RRB-
cord-015684-q10sx1dm	701	31	.	.	.
cord-015684-q10sx1dm	702	1	Brain	brain	NN
cord-015684-q10sx1dm	702	2	imaging	imaging	NN
cord-015684-q10sx1dm	702	3	techniques	technique	NNS
cord-015684-q10sx1dm	702	4	,	,	,
cord-015684-q10sx1dm	702	5	computerized	computerized	JJ
cord-015684-q10sx1dm	702	6	electrophysiology	electrophysiology	NN
cord-015684-q10sx1dm	702	7	,	,	,
cord-015684-q10sx1dm	702	8	and	and	CC
cord-015684-q10sx1dm	702	9	optical	optical	JJ
cord-015684-q10sx1dm	702	10	topography	topography	NN
cord-015684-q10sx1dm	702	11	in	in	IN
cord-015684-q10sx1dm	702	12	combination	combination	NN
cord-015684-q10sx1dm	702	13	with	with	IN
cord-015684-q10sx1dm	702	14	genotyping	genotyping	NN
cord-015684-q10sx1dm	702	15	of	of	IN
cord-015684-q10sx1dm	702	16	polygenic	polygenic	JJ
cord-015684-q10sx1dm	702	17	clusters	cluster	NNS
cord-015684-q10sx1dm	702	18	can	can	MD
cord-015684-q10sx1dm	702	19	help	help	VB
cord-015684-q10sx1dm	702	20	in	in	IN
cord-015684-q10sx1dm	702	21	the	the	DT
cord-015684-q10sx1dm	702	22	differentiation	differentiation	NN
cord-015684-q10sx1dm	702	23	of	of	IN
cord-015684-q10sx1dm	702	24	responders	responder	NNS
cord-015684-q10sx1dm	702	25	and	and	CC
cord-015684-q10sx1dm	702	26	non	non	NNS
cord-015684-q10sx1dm	702	27	-	-	NNS
cord-015684-q10sx1dm	702	28	responders	responder	NNS
cord-015684-q10sx1dm	702	29	.	.	.
cord-015684-q10sx1dm	703	1	The	the	DT
cord-015684-q10sx1dm	703	2	early	early	JJ
cord-015684-q10sx1dm	703	3	identifi	identifi	NN
cord-015684-q10sx1dm	703	4	cation	cation	NN
cord-015684-q10sx1dm	703	5	of	of	IN
cord-015684-q10sx1dm	703	6	predictive	predictive	JJ
cord-015684-q10sx1dm	703	7	risks	risk	NNS
cord-015684-q10sx1dm	703	8	requires	require	VBZ
cord-015684-q10sx1dm	703	9	genomic	genomic	JJ
cord-015684-q10sx1dm	703	10	screening	screening	NN
cord-015684-q10sx1dm	703	11	and	and	CC
cord-015684-q10sx1dm	703	12	molecular	molecular	JJ
cord-015684-q10sx1dm	703	13	diagnosis	diagnosis	NN
cord-015684-q10sx1dm	703	14	,	,	,
cord-015684-q10sx1dm	703	15	and	and	CC
cord-015684-q10sx1dm	703	16	individualized	individualized	JJ
cord-015684-q10sx1dm	703	17	preventive	preventive	JJ
cord-015684-q10sx1dm	703	18	programs	program	NNS
cord-015684-q10sx1dm	703	19	will	will	MD
cord-015684-q10sx1dm	703	20	only	only	RB
cord-015684-q10sx1dm	703	21	be	be	VB
cord-015684-q10sx1dm	703	22	achieved	achieve	VBN
cord-015684-q10sx1dm	703	23	when	when	WRB
cord-015684-q10sx1dm	703	24	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	703	25	/	/	SYM
cord-015684-q10sx1dm	703	26	pharmacogenetic	pharmacogenetic	NN
cord-015684-q10sx1dm	703	27	protocols	protocol	NNS
cord-015684-q10sx1dm	703	28	are	be	VBP
cord-015684-q10sx1dm	703	29	incorporated	incorporate	VBN
cord-015684-q10sx1dm	703	30	to	to	IN
cord-015684-q10sx1dm	703	31	the	the	DT
cord-015684-q10sx1dm	703	32	clinical	clinical	JJ
cord-015684-q10sx1dm	703	33	armamentarium	armamentarium	NN
cord-015684-q10sx1dm	703	34	with	with	IN
cord-015684-q10sx1dm	703	35	powerful	powerful	JJ
cord-015684-q10sx1dm	703	36	bioinformatics	bioinformatics	NN
cord-015684-q10sx1dm	703	37	support	support	NN
cord-015684-q10sx1dm	703	38	.	.	.
cord-015684-q10sx1dm	704	1	18	18	CD
cord-015684-q10sx1dm	704	2	-	-	SYM
cord-015684-q10sx1dm	704	3	20,74,75.109	20,74,75.109	CD
cord-015684-q10sx1dm	705	1	An	an	DT
cord-015684-q10sx1dm	705	2	important	important	JJ
cord-015684-q10sx1dm	705	3	issue	issue	NN
cord-015684-q10sx1dm	705	4	in	in	IN
cord-015684-q10sx1dm	705	5	AD	ad	NN
cord-015684-q10sx1dm	705	6	therapeutics	therapeutic	NNS
cord-015684-q10sx1dm	705	7	is	be	VBZ
cord-015684-q10sx1dm	705	8	that	that	IN
cord-015684-q10sx1dm	705	9	antidementia	antidementia	NN
cord-015684-q10sx1dm	705	10	drugs	drug	NNS
cord-015684-q10sx1dm	705	11	should	should	MD
cord-015684-q10sx1dm	705	12	be	be	VB
cord-015684-q10sx1dm	705	13	effective	effective	JJ
cord-015684-q10sx1dm	705	14	in	in	IN
cord-015684-q10sx1dm	705	15	covering	cover	VBG
cord-015684-q10sx1dm	705	16	the	the	DT
cord-015684-q10sx1dm	705	17	clinical	clinical	JJ
cord-015684-q10sx1dm	705	18	spectrum	spectrum	NN
cord-015684-q10sx1dm	705	19	of	of	IN
cord-015684-q10sx1dm	705	20	dementia	dementia	NN
cord-015684-q10sx1dm	705	21	symptoms	symptom	NNS
cord-015684-q10sx1dm	705	22	represented	represent	VBN
cord-015684-q10sx1dm	705	23	by	by	IN
cord-015684-q10sx1dm	705	24	memory	memory	NN
cord-015684-q10sx1dm	705	25	defi	defi	NNP
cord-015684-q10sx1dm	705	26	cits	cits	NNP
cord-015684-q10sx1dm	705	27	,	,	,
cord-015684-q10sx1dm	705	28	behavioural	behavioural	JJ
cord-015684-q10sx1dm	705	29	changes	change	NNS
cord-015684-q10sx1dm	705	30	,	,	,
cord-015684-q10sx1dm	705	31	and	and	CC
cord-015684-q10sx1dm	705	32	functional	functional	JJ
cord-015684-q10sx1dm	705	33	decline	decline	NN
cord-015684-q10sx1dm	705	34	.	.	.
cord-015684-q10sx1dm	706	1	It	-PRON-	PRP
cord-015684-q10sx1dm	706	2	is	be	VBZ
cord-015684-q10sx1dm	706	3	diffi	diffi	JJ
cord-015684-q10sx1dm	706	4	cult	cult	NN
cord-015684-q10sx1dm	706	5	(	(	-LRB-
cord-015684-q10sx1dm	706	6	or	or	CC
cord-015684-q10sx1dm	706	7	impossible	impossible	JJ
cord-015684-q10sx1dm	706	8	)	)	-RRB-
cord-015684-q10sx1dm	706	9	that	that	IN
cord-015684-q10sx1dm	706	10	a	a	DT
cord-015684-q10sx1dm	706	11	single	single	JJ
cord-015684-q10sx1dm	706	12	drug	drug	NN
cord-015684-q10sx1dm	706	13	be	be	VB
cord-015684-q10sx1dm	706	14	able	able	JJ
cord-015684-q10sx1dm	706	15	to	to	TO
cord-015684-q10sx1dm	706	16	fulfi	fulfi	NNP
cord-015684-q10sx1dm	706	17	l	l	NNP
cord-015684-q10sx1dm	706	18	this	this	DT
cord-015684-q10sx1dm	706	19	criteria	criterion	NNS
cord-015684-q10sx1dm	706	20	.	.	.
cord-015684-q10sx1dm	707	1	A	a	DT
cord-015684-q10sx1dm	707	2	potential	potential	JJ
cord-015684-q10sx1dm	707	3	solution	solution	NN
cord-015684-q10sx1dm	707	4	to	to	IN
cord-015684-q10sx1dm	707	5	this	this	DT
cord-015684-q10sx1dm	707	6	problem	problem	NN
cord-015684-q10sx1dm	707	7	is	be	VBZ
cord-015684-q10sx1dm	707	8	the	the	DT
cord-015684-q10sx1dm	707	9	implementation	implementation	NN
cord-015684-q10sx1dm	707	10	of	of	IN
cord-015684-q10sx1dm	707	11	cost	cost	NN
cord-015684-q10sx1dm	707	12	-	-	HYPH
cord-015684-q10sx1dm	707	13	effective	effective	JJ
cord-015684-q10sx1dm	707	14	,	,	,
cord-015684-q10sx1dm	707	15	multifactorial	multifactorial	JJ
cord-015684-q10sx1dm	707	16	(	(	-LRB-
cord-015684-q10sx1dm	707	17	combination	combination	NN
cord-015684-q10sx1dm	707	18	)	)	-RRB-
cord-015684-q10sx1dm	707	19	treatments	treatment	NNS
cord-015684-q10sx1dm	707	20	integrating	integrate	VBG
cord-015684-q10sx1dm	707	21	several	several	JJ
cord-015684-q10sx1dm	707	22	drugs	drug	NNS
cord-015684-q10sx1dm	707	23	,	,	,
cord-015684-q10sx1dm	707	24	taking	take	VBG
cord-015684-q10sx1dm	707	25	into	into	IN
cord-015684-q10sx1dm	707	26	consideration	consideration	NN
cord-015684-q10sx1dm	707	27	that	that	IN
cord-015684-q10sx1dm	707	28	traditional	traditional	JJ
cord-015684-q10sx1dm	707	29	neuroleptics	neuroleptic	NNS
cord-015684-q10sx1dm	707	30	and	and	CC
cord-015684-q10sx1dm	707	31	novel	novel	JJ
cord-015684-q10sx1dm	707	32	antipsychotics	antipsychotic	NNS
cord-015684-q10sx1dm	707	33	(	(	-LRB-
cord-015684-q10sx1dm	707	34	and	and	CC
cord-015684-q10sx1dm	707	35	many	many	JJ
cord-015684-q10sx1dm	707	36	other	other	JJ
cord-015684-q10sx1dm	707	37	psychotropics	psychotropic	NNS
cord-015684-q10sx1dm	707	38	)	)	-RRB-
cord-015684-q10sx1dm	707	39	deteriorate	deteriorate	VBP
cord-015684-q10sx1dm	707	40	both	both	CC
cord-015684-q10sx1dm	707	41	cognitive	cognitive	JJ
cord-015684-q10sx1dm	707	42	and	and	CC
cord-015684-q10sx1dm	707	43	psychomotor	psychomotor	NN
cord-015684-q10sx1dm	707	44	functions	function	NNS
cord-015684-q10sx1dm	707	45	in	in	IN
cord-015684-q10sx1dm	707	46	the	the	DT
cord-015684-q10sx1dm	707	47	elderly	elderly	JJ
cord-015684-q10sx1dm	707	48	and	and	CC
cord-015684-q10sx1dm	707	49	may	may	MD
cord-015684-q10sx1dm	707	50	also	also	RB
cord-015684-q10sx1dm	707	51	increase	increase	VB
cord-015684-q10sx1dm	707	52	the	the	DT
cord-015684-q10sx1dm	707	53	risk	risk	NN
cord-015684-q10sx1dm	707	54	of	of	IN
cord-015684-q10sx1dm	707	55	stroke	stroke	NN
cord-015684-q10sx1dm	707	56	.	.	.
cord-015684-q10sx1dm	708	1	198	198	CD
cord-015684-q10sx1dm	709	1	Few	few	JJ
cord-015684-q10sx1dm	709	2	studies	study	NNS
cord-015684-q10sx1dm	709	3	with	with	IN
cord-015684-q10sx1dm	709	4	combination	combination	NN
cord-015684-q10sx1dm	709	5	treatments	treatment	NNS
cord-015684-q10sx1dm	709	6	have	have	VBP
cord-015684-q10sx1dm	709	7	been	be	VBN
cord-015684-q10sx1dm	709	8	reported	report	VBN
cord-015684-q10sx1dm	709	9	and	and	CC
cord-015684-q10sx1dm	709	10	most	most	JJS
cord-015684-q10sx1dm	709	11	of	of	IN
cord-015684-q10sx1dm	709	12	them	-PRON-	PRP
cord-015684-q10sx1dm	709	13	are	be	VBP
cord-015684-q10sx1dm	709	14	poorly	poorly	RB
cord-015684-q10sx1dm	709	15	designed	design	VBN
cord-015684-q10sx1dm	709	16	.	.	.
cord-015684-q10sx1dm	710	1	We	-PRON-	PRP
cord-015684-q10sx1dm	710	2	have	have	VBP
cord-015684-q10sx1dm	710	3	also	also	RB
cord-015684-q10sx1dm	710	4	to	to	TO
cord-015684-q10sx1dm	710	5	realize	realize	VB
cord-015684-q10sx1dm	710	6	that	that	IN
cord-015684-q10sx1dm	710	7	the	the	DT
cord-015684-q10sx1dm	710	8	vast	vast	JJ
cord-015684-q10sx1dm	710	9	majority	majority	NN
cord-015684-q10sx1dm	710	10	of	of	IN
cord-015684-q10sx1dm	710	11	dementia	dementia	NN
cord-015684-q10sx1dm	710	12	cases	case	NNS
cord-015684-q10sx1dm	710	13	in	in	IN
cord-015684-q10sx1dm	710	14	people	people	NNS
cord-015684-q10sx1dm	710	15	older	old	JJR
cord-015684-q10sx1dm	710	16	than	than	IN
cord-015684-q10sx1dm	710	17	75	75	CD
cord-015684-q10sx1dm	710	18	-	-	SYM
cord-015684-q10sx1dm	710	19	80	80	CD
cord-015684-q10sx1dm	710	20	%	%	NN
cord-015684-q10sx1dm	710	21	are	be	VBP
cord-015684-q10sx1dm	710	22	of	of	IN
cord-015684-q10sx1dm	710	23	a	a	DT
cord-015684-q10sx1dm	710	24	mixed	mixed	JJ
cord-015684-q10sx1dm	710	25	type	type	NN
cord-015684-q10sx1dm	710	26	,	,	,
cord-015684-q10sx1dm	710	27	in	in	IN
cord-015684-q10sx1dm	710	28	which	which	WDT
cord-015684-q10sx1dm	710	29	the	the	DT
cord-015684-q10sx1dm	710	30	cerebrovascular	cerebrovascular	JJ
cord-015684-q10sx1dm	710	31	component	component	NN
cord-015684-q10sx1dm	710	32	associated	associate	VBN
cord-015684-q10sx1dm	710	33	with	with	IN
cord-015684-q10sx1dm	710	34	neurodegeneration	neurodegeneration	NN
cord-015684-q10sx1dm	710	35	can	can	MD
cord-015684-q10sx1dm	710	36	not	not	RB
cord-015684-q10sx1dm	710	37	be	be	VB
cord-015684-q10sx1dm	710	38	therapeutically	therapeutically	RB
cord-015684-q10sx1dm	710	39	neglected	neglect	VBN
cord-015684-q10sx1dm	710	40	.	.	.
cord-015684-q10sx1dm	711	1	In	in	IN
cord-015684-q10sx1dm	711	2	most	most	JJS
cord-015684-q10sx1dm	711	3	cases	case	NNS
cord-015684-q10sx1dm	711	4	of	of	IN
cord-015684-q10sx1dm	711	5	dementia	dementia	NN
cord-015684-q10sx1dm	711	6	,	,	,
cord-015684-q10sx1dm	711	7	the	the	DT
cord-015684-q10sx1dm	711	8	multifactorial	multifactorial	JJ
cord-015684-q10sx1dm	711	9	(	(	-LRB-
cord-015684-q10sx1dm	711	10	combination	combination	NN
cord-015684-q10sx1dm	711	11	)	)	-RRB-
cord-015684-q10sx1dm	711	12	therapy	therapy	NN
cord-015684-q10sx1dm	711	13	appears	appear	VBZ
cord-015684-q10sx1dm	711	14	to	to	TO
cord-015684-q10sx1dm	711	15	be	be	VB
cord-015684-q10sx1dm	711	16	the	the	DT
cord-015684-q10sx1dm	711	17	most	most	RBS
cord-015684-q10sx1dm	711	18	effective	effective	JJ
cord-015684-q10sx1dm	711	19	strategy	strategy	NN
cord-015684-q10sx1dm	711	20	.	.	.
cord-015684-q10sx1dm	712	1	[	[	-LRB-
cord-015684-q10sx1dm	712	2	18	18	CD
cord-015684-q10sx1dm	712	3	]	]	-RRB-
cord-015684-q10sx1dm	712	4	[	[	-LRB-
cord-015684-q10sx1dm	712	5	19	19	CD
cord-015684-q10sx1dm	712	6	]	]	-RRB-
cord-015684-q10sx1dm	712	7	[	[	-LRB-
cord-015684-q10sx1dm	712	8	20	20	CD
cord-015684-q10sx1dm	712	9	]	]	-RRB-
cord-015684-q10sx1dm	712	10	[	[	-LRB-
cord-015684-q10sx1dm	712	11	74	74	CD
cord-015684-q10sx1dm	712	12	]	]	-RRB-
cord-015684-q10sx1dm	712	13	[	[	-LRB-
cord-015684-q10sx1dm	712	14	75	75	CD
cord-015684-q10sx1dm	712	15	]	]	-RRB-
cord-015684-q10sx1dm	712	16	[	[	-LRB-
cord-015684-q10sx1dm	712	17	76	76	CD
cord-015684-q10sx1dm	712	18	]	]	-RRB-
cord-015684-q10sx1dm	712	19	[	[	-LRB-
cord-015684-q10sx1dm	712	20	77	77	CD
cord-015684-q10sx1dm	712	21	]	]	-RRB-
cord-015684-q10sx1dm	712	22	109	109	CD
cord-015684-q10sx1dm	713	1	The	the	DT
cord-015684-q10sx1dm	713	2	combination	combination	NN
cord-015684-q10sx1dm	713	3	of	of	IN
cord-015684-q10sx1dm	713	4	several	several	JJ
cord-015684-q10sx1dm	713	5	drugs	drug	NNS
cord-015684-q10sx1dm	713	6	(	(	-LRB-
cord-015684-q10sx1dm	713	7	neuroprotectants	neuroprotectant	NNS
cord-015684-q10sx1dm	713	8	,	,	,
cord-015684-q10sx1dm	713	9	vasoactive	vasoactive	JJ
cord-015684-q10sx1dm	713	10	substances	substance	NNS
cord-015684-q10sx1dm	713	11	,	,	,
cord-015684-q10sx1dm	713	12	AChEIs	AChEIs	NNP
cord-015684-q10sx1dm	713	13	,	,	,
cord-015684-q10sx1dm	713	14	metabolic	metabolic	JJ
cord-015684-q10sx1dm	713	15	supplementation	supplementation	NN
cord-015684-q10sx1dm	713	16	)	)	-RRB-
cord-015684-q10sx1dm	713	17	increases	increase	VBZ
cord-015684-q10sx1dm	713	18	the	the	DT
cord-015684-q10sx1dm	713	19	direct	direct	JJ
cord-015684-q10sx1dm	713	20	costs	cost	NNS
cord-015684-q10sx1dm	713	21	(	(	-LRB-
cord-015684-q10sx1dm	713	22	e.g.	e.g.	RB
cord-015684-q10sx1dm	713	23	,	,	,
cord-015684-q10sx1dm	713	24	medication	medication	NN
cord-015684-q10sx1dm	713	25	)	)	-RRB-
cord-015684-q10sx1dm	713	26	by	by	IN
cord-015684-q10sx1dm	713	27	5	5	CD
cord-015684-q10sx1dm	713	28	-	-	SYM
cord-015684-q10sx1dm	713	29	10	10	CD
cord-015684-q10sx1dm	713	30	%	%	NN
cord-015684-q10sx1dm	713	31	,	,	,
cord-015684-q10sx1dm	713	32	but	but	CC
cord-015684-q10sx1dm	713	33	in	in	IN
cord-015684-q10sx1dm	713	34	turn	turn	NN
cord-015684-q10sx1dm	713	35	,	,	,
cord-015684-q10sx1dm	713	36	annual	annual	JJ
cord-015684-q10sx1dm	713	37	global	global	JJ
cord-015684-q10sx1dm	713	38	costs	cost	NNS
cord-015684-q10sx1dm	713	39	are	be	VBP
cord-015684-q10sx1dm	713	40	reduced	reduce	VBN
cord-015684-q10sx1dm	713	41	by	by	IN
cord-015684-q10sx1dm	713	42	approximately	approximately	RB
cord-015684-q10sx1dm	713	43	18	18	CD
cord-015684-q10sx1dm	713	44	-	-	SYM
cord-015684-q10sx1dm	713	45	20	20	CD
cord-015684-q10sx1dm	713	46	%	%	NN
cord-015684-q10sx1dm	713	47	and	and	CC
cord-015684-q10sx1dm	713	48	the	the	DT
cord-015684-q10sx1dm	713	49	average	average	JJ
cord-015684-q10sx1dm	713	50	survival	survival	NN
cord-015684-q10sx1dm	713	51	rate	rate	NN
cord-015684-q10sx1dm	713	52	increases	increase	VBZ
cord-015684-q10sx1dm	713	53	about	about	IN
cord-015684-q10sx1dm	713	54	30	30	CD
cord-015684-q10sx1dm	713	55	%	%	NN
cord-015684-q10sx1dm	713	56	(	(	-LRB-
cord-015684-q10sx1dm	713	57	from	from	IN
cord-015684-q10sx1dm	713	58	8	8	CD
cord-015684-q10sx1dm	713	59	to	to	TO
cord-015684-q10sx1dm	713	60	12	12	CD
cord-015684-q10sx1dm	713	61	years	year	NNS
cord-015684-q10sx1dm	713	62	post	post	NN
cord-015684-q10sx1dm	713	63	-	-	JJ
cord-015684-q10sx1dm	713	64	diagnosis	diagnosis	JJ
cord-015684-q10sx1dm	713	65	)	)	-RRB-
cord-015684-q10sx1dm	713	66	.	.	.
cord-015684-q10sx1dm	714	1	There	there	EX
cord-015684-q10sx1dm	714	2	are	be	VBP
cord-015684-q10sx1dm	714	3	major	major	JJ
cord-015684-q10sx1dm	714	4	concerns	concern	NNS
cord-015684-q10sx1dm	714	5	regarding	regard	VBG
cord-015684-q10sx1dm	714	6	the	the	DT
cord-015684-q10sx1dm	714	7	validity	validity	NN
cord-015684-q10sx1dm	714	8	of	of	IN
cord-015684-q10sx1dm	714	9	clinical	clinical	JJ
cord-015684-q10sx1dm	714	10	trials	trial	NNS
cord-015684-q10sx1dm	714	11	in	in	IN
cord-015684-q10sx1dm	714	12	patients	patient	NNS
cord-015684-q10sx1dm	714	13	with	with	IN
cord-015684-q10sx1dm	714	14	severe	severe	JJ
cord-015684-q10sx1dm	714	15	dementia	dementia	NN
cord-015684-q10sx1dm	714	16	.	.	.
cord-015684-q10sx1dm	715	1	Despite	despite	IN
cord-015684-q10sx1dm	715	2	the	the	DT
cord-015684-q10sx1dm	715	3	questionable	questionable	JJ
cord-015684-q10sx1dm	715	4	experience	experience	NN
cord-015684-q10sx1dm	715	5	with	with	IN
cord-015684-q10sx1dm	715	6	memantine	memantine	NNP
cord-015684-q10sx1dm	715	7	,	,	,
cord-015684-q10sx1dm	715	8	199	199	CD
cord-015684-q10sx1dm	715	9	simi	simi	NNP
cord-015684-q10sx1dm	715	10	-	-	HYPH
cord-015684-q10sx1dm	715	11	lar	lar	NNP
cord-015684-q10sx1dm	715	12	strategies	strategy	NNS
cord-015684-q10sx1dm	715	13	have	have	VBP
cord-015684-q10sx1dm	715	14	been	be	VBN
cord-015684-q10sx1dm	715	15	used	use	VBN
cord-015684-q10sx1dm	715	16	to	to	TO
cord-015684-q10sx1dm	715	17	demonstrate	demonstrate	VB
cord-015684-q10sx1dm	715	18	the	the	DT
cord-015684-q10sx1dm	715	19	utility	utility	NN
cord-015684-q10sx1dm	715	20	of	of	IN
cord-015684-q10sx1dm	715	21	donepezil	donepezil	NNP
cord-015684-q10sx1dm	715	22	in	in	IN
cord-015684-q10sx1dm	715	23	severe	severe	JJ
cord-015684-q10sx1dm	715	24	AD	ad	NN
cord-015684-q10sx1dm	715	25	.	.	.
cord-015684-q10sx1dm	716	1	200	200	CD
cord-015684-q10sx1dm	717	1	This	this	DT
cord-015684-q10sx1dm	717	2	kind	kind	NN
cord-015684-q10sx1dm	717	3	of	of	IN
cord-015684-q10sx1dm	717	4	studies	study	NNS
cord-015684-q10sx1dm	717	5	bears	bear	VBZ
cord-015684-q10sx1dm	717	6	some	some	DT
cord-015684-q10sx1dm	717	7	important	important	JJ
cord-015684-q10sx1dm	717	8	pitfalls	pitfall	NNS
cord-015684-q10sx1dm	717	9	,	,	,
cord-015684-q10sx1dm	717	10	including	include	VBG
cord-015684-q10sx1dm	717	11	(	(	-LRB-
cord-015684-q10sx1dm	717	12	a	a	DT
cord-015684-q10sx1dm	717	13	)	)	-RRB-
cord-015684-q10sx1dm	717	14	short	short	JJ
cord-015684-q10sx1dm	717	15	duration	duration	NN
cord-015684-q10sx1dm	717	16	(	(	-LRB-
cord-015684-q10sx1dm	717	17	<	<	NNP
cord-015684-q10sx1dm	717	18	1	1	CD
cord-015684-q10sx1dm	717	19	year	year	NN
cord-015684-q10sx1dm	717	20	)	)	-RRB-
cord-015684-q10sx1dm	717	21	,	,	,
cord-015684-q10sx1dm	717	22	(	(	-LRB-
cord-015684-q10sx1dm	717	23	b	b	NN
cord-015684-q10sx1dm	717	24	)	)	-RRB-
cord-015684-q10sx1dm	717	25	institutionalized	institutionalize	VBN
cord-015684-q10sx1dm	717	26	patients	patient	NNS
cord-015684-q10sx1dm	717	27	,	,	,
cord-015684-q10sx1dm	717	28	(	(	-LRB-
cord-015684-q10sx1dm	717	29	c	c	NN
cord-015684-q10sx1dm	717	30	)	)	-RRB-
cord-015684-q10sx1dm	717	31	patients	patient	NNS
cord-015684-q10sx1dm	717	32	receiving	receive	VBG
cord-015684-q10sx1dm	717	33	many	many	JJ
cord-015684-q10sx1dm	717	34	different	different	JJ
cord-015684-q10sx1dm	717	35	types	type	NNS
cord-015684-q10sx1dm	717	36	of	of	IN
cord-015684-q10sx1dm	717	37	drugs	drug	NNS
cord-015684-q10sx1dm	717	38	,	,	,
cord-015684-q10sx1dm	717	39	(	(	-LRB-
cord-015684-q10sx1dm	717	40	d	d	LS
cord-015684-q10sx1dm	717	41	)	)	-RRB-
cord-015684-q10sx1dm	717	42	non	non	JJ
cord-015684-q10sx1dm	717	43	-	-	JJ
cord-015684-q10sx1dm	717	44	evaluated	evaluate	VBN
cord-015684-q10sx1dm	717	45	drug	drug	NN
cord-015684-q10sx1dm	717	46	-	-	HYPH
cord-015684-q10sx1dm	717	47	drug	drug	NN
cord-015684-q10sx1dm	717	48	interactions	interaction	NNS
cord-015684-q10sx1dm	717	49	,	,	,
cord-015684-q10sx1dm	717	50	(	(	-LRB-
cord-015684-q10sx1dm	717	51	e	e	LS
cord-015684-q10sx1dm	717	52	)	)	-RRB-
cord-015684-q10sx1dm	717	53	side	side	NN
cord-015684-q10sx1dm	717	54	-	-	HYPH
cord-015684-q10sx1dm	717	55	effects	effect	NNS
cord-015684-q10sx1dm	717	56	(	(	-LRB-
cord-015684-q10sx1dm	717	57	e.g.	e.g.	RB
cord-015684-q10sx1dm	717	58	,	,	,
cord-015684-q10sx1dm	717	59	hallucinations	hallucination	NNS
cord-015684-q10sx1dm	717	60	,	,	,
cord-015684-q10sx1dm	717	61	gastrointestinal	gastrointestinal	JJ
cord-015684-q10sx1dm	717	62	disorders	disorder	NNS
cord-015684-q10sx1dm	717	63	)	)	-RRB-
cord-015684-q10sx1dm	717	64	that	that	WDT
cord-015684-q10sx1dm	717	65	may	may	MD
cord-015684-q10sx1dm	717	66	require	require	VB
cord-015684-q10sx1dm	717	67	the	the	DT
cord-015684-q10sx1dm	717	68	administration	administration	NN
cord-015684-q10sx1dm	717	69	of	of	IN
cord-015684-q10sx1dm	717	70	additional	additional	JJ
cord-015684-q10sx1dm	717	71	medication	medication	NN
cord-015684-q10sx1dm	717	72	,	,	,
cord-015684-q10sx1dm	717	73	(	(	-LRB-
cord-015684-q10sx1dm	717	74	f	f	NNP
cord-015684-q10sx1dm	717	75	)	)	-RRB-
cord-015684-q10sx1dm	717	76	lack	lack	NN
cord-015684-q10sx1dm	717	77	of	of	IN
cord-015684-q10sx1dm	717	78	biological	biological	JJ
cord-015684-q10sx1dm	717	79	parameters	parameter	NNS
cord-015684-q10sx1dm	717	80	demonstrating	demonstrate	VBG
cord-015684-q10sx1dm	717	81	actual	actual	JJ
cord-015684-q10sx1dm	717	82	benefi	benefi	JJ
cord-015684-q10sx1dm	717	83	ts	ts	NN
cord-015684-q10sx1dm	717	84	,	,	,
cord-015684-q10sx1dm	717	85	and	and	CC
cord-015684-q10sx1dm	717	86	(	(	-LRB-
cord-015684-q10sx1dm	717	87	e	e	LS
cord-015684-q10sx1dm	717	88	)	)	-RRB-
cord-015684-q10sx1dm	717	89	no	no	DT
cord-015684-q10sx1dm	717	90	cost	cost	NN
cord-015684-q10sx1dm	717	91	-	-	HYPH
cord-015684-q10sx1dm	717	92	effectiveness	effectiveness	NN
cord-015684-q10sx1dm	717	93	assessment	assessment	NN
cord-015684-q10sx1dm	717	94	,	,	,
cord-015684-q10sx1dm	717	95	among	among	IN
cord-015684-q10sx1dm	717	96	many	many	JJ
cord-015684-q10sx1dm	717	97	other	other	JJ
cord-015684-q10sx1dm	717	98	possibilities	possibility	NNS
cord-015684-q10sx1dm	717	99	of	of	IN
cord-015684-q10sx1dm	717	100	technical	technical	JJ
cord-015684-q10sx1dm	717	101	criticism	criticism	NN
cord-015684-q10sx1dm	717	102	.	.	.
cord-015684-q10sx1dm	718	1	[	[	-LRB-
cord-015684-q10sx1dm	718	2	18	18	CD
cord-015684-q10sx1dm	718	3	]	]	-RRB-
cord-015684-q10sx1dm	718	4	[	[	-LRB-
cord-015684-q10sx1dm	718	5	19	19	CD
cord-015684-q10sx1dm	718	6	]	]	-RRB-
cord-015684-q10sx1dm	718	7	[	[	-LRB-
cord-015684-q10sx1dm	718	8	20	20	CD
cord-015684-q10sx1dm	718	9	]	]	-RRB-
cord-015684-q10sx1dm	718	10	109	109	CD
cord-015684-q10sx1dm	718	11	,	,	,
cord-015684-q10sx1dm	718	12	201	201	CD
cord-015684-q10sx1dm	719	1	Some	some	DT
cord-015684-q10sx1dm	719	2	of	of	IN
cord-015684-q10sx1dm	719	3	these	these	DT
cord-015684-q10sx1dm	719	4	methodological	methodological	JJ
cord-015684-q10sx1dm	719	5	(	(	-LRB-
cord-015684-q10sx1dm	719	6	and	and	CC
cord-015684-q10sx1dm	719	7	costly	costly	JJ
cord-015684-q10sx1dm	719	8	)	)	-RRB-
cord-015684-q10sx1dm	719	9	problems	problem	NNS
cord-015684-q10sx1dm	719	10	might	may	MD
cord-015684-q10sx1dm	719	11	be	be	VB
cord-015684-q10sx1dm	719	12	overcome	overcome	VBN
cord-015684-q10sx1dm	719	13	with	with	IN
cord-015684-q10sx1dm	719	14	the	the	DT
cord-015684-q10sx1dm	719	15	introduction	introduction	NN
cord-015684-q10sx1dm	719	16	of	of	IN
cord-015684-q10sx1dm	719	17	pharmacogenetic/	pharmacogenetic/	CD
cord-015684-q10sx1dm	719	18	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	719	19	strategies	strategy	NNS
cord-015684-q10sx1dm	719	20	to	to	TO
cord-015684-q10sx1dm	719	21	identify	identify	VB
cord-015684-q10sx1dm	719	22	good	good	JJ
cord-015684-q10sx1dm	719	23	responders	responder	NNS
cord-015684-q10sx1dm	719	24	who	who	WP
cord-015684-q10sx1dm	719	25	might	may	MD
cord-015684-q10sx1dm	719	26	obtain	obtain	VB
cord-015684-q10sx1dm	719	27	some	some	DT
cord-015684-q10sx1dm	719	28	benefi	benefi	NNP
cord-015684-q10sx1dm	719	29	t	t	NN
cord-015684-q10sx1dm	719	30	by	by	IN
cord-015684-q10sx1dm	719	31	taking	take	VBG
cord-015684-q10sx1dm	719	32	expensive	expensive	JJ
cord-015684-q10sx1dm	719	33	medications	medication	NNS
cord-015684-q10sx1dm	719	34	.	.	.
cord-015684-q10sx1dm	720	1	Major	major	JJ
cord-015684-q10sx1dm	720	2	impact	impact	NN
cord-015684-q10sx1dm	720	3	factors	factor	NNS
cord-015684-q10sx1dm	720	4	associated	associate	VBN
cord-015684-q10sx1dm	720	5	with	with	IN
cord-015684-q10sx1dm	720	6	drug	drug	NN
cord-015684-q10sx1dm	720	7	effi	effi	NNP
cord-015684-q10sx1dm	720	8	cacy	cacy	NNP
cord-015684-q10sx1dm	720	9	and	and	CC
cord-015684-q10sx1dm	720	10	safety	safety	NN
cord-015684-q10sx1dm	720	11	include	include	VBP
cord-015684-q10sx1dm	720	12	the	the	DT
cord-015684-q10sx1dm	720	13	following	follow	VBG
cord-015684-q10sx1dm	720	14	:	:	:
cord-015684-q10sx1dm	720	15	(	(	-LRB-
cord-015684-q10sx1dm	720	16	i	i	NN
cord-015684-q10sx1dm	720	17	)	)	-RRB-
cord-015684-q10sx1dm	721	1	the	the	DT
cord-015684-q10sx1dm	721	2	mechanisms	mechanism	NNS
cord-015684-q10sx1dm	721	3	of	of	IN
cord-015684-q10sx1dm	721	4	action	action	NN
cord-015684-q10sx1dm	721	5	of	of	IN
cord-015684-q10sx1dm	721	6	drugs	drug	NNS
cord-015684-q10sx1dm	721	7	,	,	,
cord-015684-q10sx1dm	721	8	(	(	-LRB-
cord-015684-q10sx1dm	721	9	ii	ii	NN
cord-015684-q10sx1dm	721	10	)	)	-RRB-
cord-015684-q10sx1dm	721	11	drug	drug	NN
cord-015684-q10sx1dm	721	12	-	-	HYPH
cord-015684-q10sx1dm	721	13	specifi	specifi	NN
cord-015684-q10sx1dm	721	14	c	c	NN
cord-015684-q10sx1dm	721	15	adverse	adverse	JJ
cord-015684-q10sx1dm	721	16	reactions	reaction	NNS
cord-015684-q10sx1dm	721	17	,	,	,
cord-015684-q10sx1dm	721	18	(	(	-LRB-
cord-015684-q10sx1dm	721	19	iii	iii	NN
cord-015684-q10sx1dm	721	20	)	)	-RRB-
cord-015684-q10sx1dm	721	21	drug	drug	NN
cord-015684-q10sx1dm	721	22	-	-	HYPH
cord-015684-q10sx1dm	721	23	drug	drug	NN
cord-015684-q10sx1dm	721	24	interactions	interaction	NNS
cord-015684-q10sx1dm	721	25	,	,	,
cord-015684-q10sx1dm	721	26	(	(	-LRB-
cord-015684-q10sx1dm	721	27	iv	iv	LS
cord-015684-q10sx1dm	721	28	)	)	-RRB-
cord-015684-q10sx1dm	721	29	nutritional	nutritional	JJ
cord-015684-q10sx1dm	721	30	factors	factor	NNS
cord-015684-q10sx1dm	721	31	,	,	,
cord-015684-q10sx1dm	721	32	(	(	-LRB-
cord-015684-q10sx1dm	721	33	v	v	LS
cord-015684-q10sx1dm	721	34	)	)	-RRB-
cord-015684-q10sx1dm	721	35	vascular	vascular	JJ
cord-015684-q10sx1dm	721	36	factors	factor	NNS
cord-015684-q10sx1dm	721	37	,	,	,
cord-015684-q10sx1dm	721	38	(	(	-LRB-
cord-015684-q10sx1dm	721	39	vi	vi	NNP
cord-015684-q10sx1dm	721	40	)	)	-RRB-
cord-015684-q10sx1dm	721	41	social	social	JJ
cord-015684-q10sx1dm	721	42	factors	factor	NNS
cord-015684-q10sx1dm	721	43	,	,	,
cord-015684-q10sx1dm	721	44	and	and	CC
cord-015684-q10sx1dm	721	45	(	(	-LRB-
cord-015684-q10sx1dm	721	46	vii	vii	NN
cord-015684-q10sx1dm	721	47	)	)	-RRB-
cord-015684-q10sx1dm	721	48	genomic	genomic	JJ
cord-015684-q10sx1dm	721	49	factors	factor	NNS
cord-015684-q10sx1dm	721	50	(	(	-LRB-
cord-015684-q10sx1dm	721	51	nutrigenetics	nutrigenetic	NNS
cord-015684-q10sx1dm	721	52	,	,	,
cord-015684-q10sx1dm	721	53	nutrigenomics	nutrigenomic	NNS
cord-015684-q10sx1dm	721	54	,	,	,
cord-015684-q10sx1dm	721	55	pharmacogenetics	pharmacogenetics	NNP
cord-015684-q10sx1dm	721	56	,	,	,
cord-015684-q10sx1dm	721	57	pharmacogenomics	pharmacogenomics	NNP
cord-015684-q10sx1dm	721	58	)	)	-RRB-
cord-015684-q10sx1dm	721	59	.	.	.
cord-015684-q10sx1dm	722	1	Among	among	IN
cord-015684-q10sx1dm	722	2	genomic	genomic	JJ
cord-015684-q10sx1dm	722	3	factors	factor	NNS
cord-015684-q10sx1dm	722	4	,	,	,
cord-015684-q10sx1dm	722	5	nutrigenetics	nutrigenetic	NNS
cord-015684-q10sx1dm	722	6	/	/	SYM
cord-015684-q10sx1dm	722	7	nutrigenomics	nutrigenomic	NNS
cord-015684-q10sx1dm	722	8	and	and	CC
cord-015684-q10sx1dm	722	9	pharmacogenetics	pharmacogenetics	NNP
cord-015684-q10sx1dm	722	10	/	/	SYM
cord-015684-q10sx1dm	722	11	pharmacogenomics	pharmacogenomic	NNS
cord-015684-q10sx1dm	722	12	account	account	VBP
cord-015684-q10sx1dm	722	13	for	for	IN
cord-015684-q10sx1dm	722	14	more	more	JJR
cord-015684-q10sx1dm	722	15	than	than	IN
cord-015684-q10sx1dm	722	16	80	80	CD
cord-015684-q10sx1dm	722	17	%	%	NN
cord-015684-q10sx1dm	722	18	of	of	IN
cord-015684-q10sx1dm	722	19	effi	effi	NNP
cord-015684-q10sx1dm	722	20	cacy	cacy	NNP
cord-015684-q10sx1dm	722	21	-	-	HYPH
cord-015684-q10sx1dm	722	22	safety	safety	NN
cord-015684-q10sx1dm	722	23	outcomes	outcome	NNS
cord-015684-q10sx1dm	722	24	in	in	IN
cord-015684-q10sx1dm	722	25	current	current	JJ
cord-015684-q10sx1dm	722	26	therapeutics	therapeutic	NNS
cord-015684-q10sx1dm	722	27	.	.	.
cord-015684-q10sx1dm	723	1	[	[	-LRB-
cord-015684-q10sx1dm	723	2	18	18	CD
cord-015684-q10sx1dm	723	3	]	]	-RRB-
cord-015684-q10sx1dm	723	4	[	[	-LRB-
cord-015684-q10sx1dm	723	5	19	19	CD
cord-015684-q10sx1dm	723	6	]	]	-RRB-
cord-015684-q10sx1dm	723	7	[	[	-LRB-
cord-015684-q10sx1dm	723	8	20	20	CD
cord-015684-q10sx1dm	723	9	]	]	-RRB-
cord-015684-q10sx1dm	723	10	74	74	CD
cord-015684-q10sx1dm	723	11	,	,	,
cord-015684-q10sx1dm	723	12	75	75	CD
cord-015684-q10sx1dm	723	13	,	,	,
cord-015684-q10sx1dm	723	14	77	77	CD
cord-015684-q10sx1dm	723	15	,	,	,
cord-015684-q10sx1dm	723	16	109	109	CD
cord-015684-q10sx1dm	724	1	Some	some	DT
cord-015684-q10sx1dm	724	2	authors	author	NNS
cord-015684-q10sx1dm	724	3	consider	consider	VBP
cord-015684-q10sx1dm	724	4	that	that	IN
cord-015684-q10sx1dm	724	5	priority	priority	NN
cord-015684-q10sx1dm	724	6	areas	area	NNS
cord-015684-q10sx1dm	724	7	for	for	IN
cord-015684-q10sx1dm	724	8	pharmacogenetic	pharmacogenetic	JJ
cord-015684-q10sx1dm	724	9	research	research	NN
cord-015684-q10sx1dm	724	10	are	be	VBP
cord-015684-q10sx1dm	724	11	to	to	TO
cord-015684-q10sx1dm	724	12	predict	predict	VB
cord-015684-q10sx1dm	724	13	serious	serious	JJ
cord-015684-q10sx1dm	724	14	adverse	adverse	JJ
cord-015684-q10sx1dm	724	15	reactions	reaction	NNS
cord-015684-q10sx1dm	724	16	(	(	-LRB-
cord-015684-q10sx1dm	724	17	ADRs	adr	NNS
cord-015684-q10sx1dm	724	18	)	)	-RRB-
cord-015684-q10sx1dm	724	19	and	and	CC
cord-015684-q10sx1dm	724	20	to	to	TO
cord-015684-q10sx1dm	724	21	establish	establish	VB
cord-015684-q10sx1dm	724	22	variation	variation	NN
cord-015684-q10sx1dm	724	23	in	in	IN
cord-015684-q10sx1dm	724	24	effi	effi	NNP
cord-015684-q10sx1dm	724	25	cacy	cacy	NNP
cord-015684-q10sx1dm	724	26	.	.	.
cord-015684-q10sx1dm	725	1	202	202	CD
cord-015684-q10sx1dm	726	1	Both	both	DT
cord-015684-q10sx1dm	726	2	requirements	requirement	NNS
cord-015684-q10sx1dm	726	3	are	be	VBP
cord-015684-q10sx1dm	726	4	necessary	necessary	JJ
cord-015684-q10sx1dm	726	5	in	in	IN
cord-015684-q10sx1dm	726	6	CNS	CNS	NNP
cord-015684-q10sx1dm	726	7	disorders	disorder	NNS
cord-015684-q10sx1dm	726	8	to	to	TO
cord-015684-q10sx1dm	726	9	cope	cope	VB
cord-015684-q10sx1dm	726	10	with	with	IN
cord-015684-q10sx1dm	726	11	effi	effi	NNP
cord-015684-q10sx1dm	726	12	cacy	cacy	NNP
cord-015684-q10sx1dm	726	13	and	and	CC
cord-015684-q10sx1dm	726	14	safety	safety	NN
cord-015684-q10sx1dm	726	15	issues	issue	NNS
cord-015684-q10sx1dm	726	16	associated	associate	VBN
cord-015684-q10sx1dm	726	17	with	with	IN
cord-015684-q10sx1dm	726	18	either	either	DT
cord-015684-q10sx1dm	726	19	current	current	JJ
cord-015684-q10sx1dm	726	20	CNS	CNS	NNP
cord-015684-q10sx1dm	726	21	drugs	drug	NNS
cord-015684-q10sx1dm	726	22	and	and	CC
cord-015684-q10sx1dm	726	23	new	new	JJ
cord-015684-q10sx1dm	726	24	drugs	drug	NNS
cord-015684-q10sx1dm	726	25	.	.	.
cord-015684-q10sx1dm	727	1	121	121	CD
cord-015684-q10sx1dm	727	2	,	,	,
cord-015684-q10sx1dm	727	3	138	138	CD
cord-015684-q10sx1dm	727	4	Since	since	IN
cord-015684-q10sx1dm	727	5	drug	drug	NN
cord-015684-q10sx1dm	727	6	response	response	NN
cord-015684-q10sx1dm	727	7	is	be	VBZ
cord-015684-q10sx1dm	727	8	a	a	DT
cord-015684-q10sx1dm	727	9	complex	complex	JJ
cord-015684-q10sx1dm	727	10	trait	trait	NN
cord-015684-q10sx1dm	727	11	,	,	,
cord-015684-q10sx1dm	727	12	genome	genome	NN
cord-015684-q10sx1dm	727	13	-	-	HYPH
cord-015684-q10sx1dm	727	14	wide	wide	JJ
cord-015684-q10sx1dm	727	15	approaches	approach	NNS
cord-015684-q10sx1dm	727	16	(	(	-LRB-
cord-015684-q10sx1dm	727	17	oligonucleotide	oligonucleotide	NN
cord-015684-q10sx1dm	727	18	microarrays	microarray	NNS
cord-015684-q10sx1dm	727	19	,	,	,
cord-015684-q10sx1dm	727	20	proteomic	proteomic	JJ
cord-015684-q10sx1dm	727	21	profi	profi	NNP
cord-015684-q10sx1dm	727	22	ling	ling	NNP
cord-015684-q10sx1dm	727	23	)	)	-RRB-
cord-015684-q10sx1dm	727	24	may	may	MD
cord-015684-q10sx1dm	727	25	provide	provide	VB
cord-015684-q10sx1dm	727	26	new	new	JJ
cord-015684-q10sx1dm	727	27	insights	insight	NNS
cord-015684-q10sx1dm	727	28	into	into	IN
cord-015684-q10sx1dm	727	29	drug	drug	NN
cord-015684-q10sx1dm	727	30	metabolism	metabolism	NN
cord-015684-q10sx1dm	727	31	and	and	CC
cord-015684-q10sx1dm	727	32	drug	drug	NN
cord-015684-q10sx1dm	727	33	response	response	NN
cord-015684-q10sx1dm	727	34	.	.	.
cord-015684-q10sx1dm	728	1	Genome	genome	NN
cord-015684-q10sx1dm	728	2	-	-	HYPH
cord-015684-q10sx1dm	728	3	wide	wide	JJ
cord-015684-q10sx1dm	728	4	family	family	NN
cord-015684-q10sx1dm	728	5	-	-	HYPH
cord-015684-q10sx1dm	728	6	based	base	VBN
cord-015684-q10sx1dm	728	7	association	association	NN
cord-015684-q10sx1dm	728	8	studies	study	NNS
cord-015684-q10sx1dm	728	9	,	,	,
cord-015684-q10sx1dm	728	10	using	use	VBG
cord-015684-q10sx1dm	728	11	single	single	JJ
cord-015684-q10sx1dm	728	12	SNPs	snp	NNS
cord-015684-q10sx1dm	728	13	or	or	CC
cord-015684-q10sx1dm	728	14	haplotypes	haplotype	NNS
cord-015684-q10sx1dm	728	15	,	,	,
cord-015684-q10sx1dm	728	16	can	can	MD
cord-015684-q10sx1dm	728	17	identify	identify	VB
cord-015684-q10sx1dm	728	18	associations	association	NNS
cord-015684-q10sx1dm	728	19	with	with	IN
cord-015684-q10sx1dm	728	20	genome	genome	NN
cord-015684-q10sx1dm	728	21	-	-	HYPH
cord-015684-q10sx1dm	728	22	wide	wide	JJ
cord-015684-q10sx1dm	728	23	signifi	signifi	NNP
cord-015684-q10sx1dm	728	24	cance	cance	NN
cord-015684-q10sx1dm	728	25	.	.	.
cord-015684-q10sx1dm	729	1	203	203	CD
cord-015684-q10sx1dm	729	2	,	,	,
cord-015684-q10sx1dm	729	3	204	204	CD
cord-015684-q10sx1dm	730	1	To	to	TO
cord-015684-q10sx1dm	730	2	achieve	achieve	VB
cord-015684-q10sx1dm	730	3	a	a	DT
cord-015684-q10sx1dm	730	4	mature	mature	JJ
cord-015684-q10sx1dm	730	5	discipline	discipline	NN
cord-015684-q10sx1dm	730	6	of	of	IN
cord-015684-q10sx1dm	730	7	pharmacogenetics	pharmacogenetic	NNS
cord-015684-q10sx1dm	730	8	and	and	CC
cord-015684-q10sx1dm	730	9	pharmacogenomics	pharmacogenomic	NNS
cord-015684-q10sx1dm	730	10	in	in	IN
cord-015684-q10sx1dm	730	11	CNS	CNS	NNP
cord-015684-q10sx1dm	730	12	disorders	disorder	NNS
cord-015684-q10sx1dm	730	13	and	and	CC
cord-015684-q10sx1dm	730	14	dementia	dementia	NN
cord-015684-q10sx1dm	730	15	it	-PRON-	PRP
cord-015684-q10sx1dm	730	16	would	would	MD
cord-015684-q10sx1dm	730	17	be	be	VB
cord-015684-q10sx1dm	730	18	convenient	convenient	JJ
cord-015684-q10sx1dm	730	19	to	to	TO
cord-015684-q10sx1dm	730	20	accelerate	accelerate	VB
cord-015684-q10sx1dm	730	21	the	the	DT
cord-015684-q10sx1dm	730	22	following	follow	VBG
cord-015684-q10sx1dm	730	23	processes	process	NNS
cord-015684-q10sx1dm	730	24	:	:	:
cord-015684-q10sx1dm	730	25	(	(	-LRB-
cord-015684-q10sx1dm	730	26	a	a	LS
cord-015684-q10sx1dm	730	27	)	)	-RRB-
cord-015684-q10sx1dm	730	28	educate	educate	VBP
cord-015684-q10sx1dm	730	29	physicians	physician	NNS
cord-015684-q10sx1dm	730	30	and	and	CC
cord-015684-q10sx1dm	730	31	the	the	DT
cord-015684-q10sx1dm	730	32	public	public	NN
cord-015684-q10sx1dm	730	33	on	on	IN
cord-015684-q10sx1dm	730	34	the	the	DT
cord-015684-q10sx1dm	730	35	use	use	NN
cord-015684-q10sx1dm	730	36	of	of	IN
cord-015684-q10sx1dm	730	37	genetic	genetic	JJ
cord-015684-q10sx1dm	730	38	/	/	SYM
cord-015684-q10sx1dm	730	39	genomic	genomic	JJ
cord-015684-q10sx1dm	730	40	screening	screening	NN
cord-015684-q10sx1dm	730	41	in	in	IN
cord-015684-q10sx1dm	730	42	the	the	DT
cord-015684-q10sx1dm	730	43	daily	daily	JJ
cord-015684-q10sx1dm	730	44	clinical	clinical	JJ
cord-015684-q10sx1dm	730	45	practice	practice	NN
cord-015684-q10sx1dm	730	46	;	;	,
cord-015684-q10sx1dm	730	47	(	(	-LRB-
cord-015684-q10sx1dm	730	48	b	b	NN
cord-015684-q10sx1dm	730	49	)	)	-RRB-
cord-015684-q10sx1dm	730	50	standardize	standardize	VB
cord-015684-q10sx1dm	730	51	genetic	genetic	JJ
cord-015684-q10sx1dm	730	52	testing	testing	NN
cord-015684-q10sx1dm	730	53	for	for	IN
cord-015684-q10sx1dm	730	54	major	major	JJ
cord-015684-q10sx1dm	730	55	categories	category	NNS
cord-015684-q10sx1dm	730	56	of	of	IN
cord-015684-q10sx1dm	730	57	drugs	drug	NNS
cord-015684-q10sx1dm	730	58	;	;	,
cord-015684-q10sx1dm	730	59	(	(	-LRB-
cord-015684-q10sx1dm	730	60	c	c	NN
cord-015684-q10sx1dm	730	61	)	)	-RRB-
cord-015684-q10sx1dm	730	62	validate	validate	VB
cord-015684-q10sx1dm	730	63	pharmacogenetic	pharmacogenetic	JJ
cord-015684-q10sx1dm	730	64	and	and	CC
cord-015684-q10sx1dm	730	65	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	730	66	procedures	procedure	NNS
cord-015684-q10sx1dm	730	67	according	accord	VBG
cord-015684-q10sx1dm	730	68	to	to	IN
cord-015684-q10sx1dm	730	69	drug	drug	NN
cord-015684-q10sx1dm	730	70	category	category	NN
cord-015684-q10sx1dm	730	71	and	and	CC
cord-015684-q10sx1dm	730	72	pathology	pathology	NN
cord-015684-q10sx1dm	730	73	;	;	,
cord-015684-q10sx1dm	730	74	(	(	-LRB-
cord-015684-q10sx1dm	730	75	d	d	LS
cord-015684-q10sx1dm	730	76	)	)	-RRB-
cord-015684-q10sx1dm	730	77	regulate	regulate	VB
cord-015684-q10sx1dm	730	78	ethical	ethical	JJ
cord-015684-q10sx1dm	730	79	,	,	,
cord-015684-q10sx1dm	730	80	social	social	JJ
cord-015684-q10sx1dm	730	81	,	,	,
cord-015684-q10sx1dm	730	82	and	and	CC
cord-015684-q10sx1dm	730	83	economic	economic	JJ
cord-015684-q10sx1dm	730	84	issues	issue	NNS
cord-015684-q10sx1dm	730	85	;	;	:
cord-015684-q10sx1dm	730	86	and	and	CC
cord-015684-q10sx1dm	730	87	(	(	-LRB-
cord-015684-q10sx1dm	730	88	e	e	LS
cord-015684-q10sx1dm	730	89	)	)	-RRB-
cord-015684-q10sx1dm	730	90	incorporate	incorporate	VB
cord-015684-q10sx1dm	730	91	pharmacogenetic	pharmacogenetic	NN
cord-015684-q10sx1dm	730	92	and	and	CC
cord-015684-q10sx1dm	730	93	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	730	94	procedures	procedure	NNS
cord-015684-q10sx1dm	730	95	to	to	IN
cord-015684-q10sx1dm	730	96	both	both	DT
cord-015684-q10sx1dm	730	97	drugs	drug	NNS
cord-015684-q10sx1dm	730	98	in	in	IN
cord-015684-q10sx1dm	730	99	development	development	NN
cord-015684-q10sx1dm	730	100	and	and	CC
cord-015684-q10sx1dm	730	101	drugs	drug	NNS
cord-015684-q10sx1dm	730	102	in	in	IN
cord-015684-q10sx1dm	730	103	the	the	DT
cord-015684-q10sx1dm	730	104	market	market	NN
cord-015684-q10sx1dm	730	105	to	to	TO
cord-015684-q10sx1dm	730	106	optimize	optimize	VB
cord-015684-q10sx1dm	730	107	therapeutics	therapeutic	NNS
cord-015684-q10sx1dm	730	108	.	.	.
cord-015684-q10sx1dm	731	1	[	[	-LRB-
cord-015684-q10sx1dm	731	2	18	18	CD
cord-015684-q10sx1dm	731	3	]	]	-RRB-
cord-015684-q10sx1dm	731	4	[	[	-LRB-
cord-015684-q10sx1dm	731	5	19	19	CD
cord-015684-q10sx1dm	731	6	]	]	-RRB-
cord-015684-q10sx1dm	731	7	[	[	-LRB-
cord-015684-q10sx1dm	731	8	20	20	CD
cord-015684-q10sx1dm	731	9	]	]	-RRB-
cord-015684-q10sx1dm	731	10	[	[	-LRB-
cord-015684-q10sx1dm	731	11	21	21	CD
cord-015684-q10sx1dm	731	12	]	]	-RRB-
cord-015684-q10sx1dm	732	1	[	[	-LRB-
cord-015684-q10sx1dm	732	2	22	22	CD
cord-015684-q10sx1dm	732	3	]	]	-RRB-
cord-015684-q10sx1dm	732	4	[	[	-LRB-
cord-015684-q10sx1dm	732	5	74	74	CD
cord-015684-q10sx1dm	732	6	]	]	-RRB-
cord-015684-q10sx1dm	733	1	[	[	-LRB-
cord-015684-q10sx1dm	733	2	75	75	CD
cord-015684-q10sx1dm	733	3	]	]	-RRB-
cord-015684-q10sx1dm	733	4	[	[	-LRB-
cord-015684-q10sx1dm	733	5	76	76	CD
cord-015684-q10sx1dm	733	6	]	]	-RRB-
cord-015684-q10sx1dm	733	7	[	[	-LRB-
cord-015684-q10sx1dm	733	8	77	77	CD
cord-015684-q10sx1dm	733	9	]	]	-RRB-
cord-015684-q10sx1dm	733	10	109	109	CD
cord-015684-q10sx1dm	733	11	,	,	,
cord-015684-q10sx1dm	733	12	205	205	CD
cord-015684-q10sx1dm	733	13	 	 	_SP
cord-015684-q10sx1dm	733	14	Costs	cost	NNS
cord-015684-q10sx1dm	733	15	of	of	IN
cord-015684-q10sx1dm	733	16	disorders	disorder	NNS
cord-015684-q10sx1dm	733	17	of	of	IN
cord-015684-q10sx1dm	733	18	the	the	DT
cord-015684-q10sx1dm	733	19	brain	brain	NN
cord-015684-q10sx1dm	733	20	in	in	IN
cord-015684-q10sx1dm	733	21	Europe	Europe	NNP
cord-015684-q10sx1dm	733	22	.	.	.
cord-015684-q10sx1dm	734	1	Executive	executive	JJ
cord-015684-q10sx1dm	734	2	summary	summary	NN
cord-015684-q10sx1dm	735	1	A	a	DT
cord-015684-q10sx1dm	735	2	conceptual	conceptual	JJ
cord-015684-q10sx1dm	735	3	introduction	introduction	NN
cord-015684-q10sx1dm	735	4	to	to	IN
cord-015684-q10sx1dm	735	5	geriatric	geriatric	JJ
cord-015684-q10sx1dm	735	6	neuroscience	neuroscience	NN
cord-015684-q10sx1dm	736	1	The	the	DT
cord-015684-q10sx1dm	736	2	clinical	clinical	JJ
cord-015684-q10sx1dm	736	3	and	and	CC
cord-015684-q10sx1dm	736	4	costeffectiveness	costeffectiveness	NN
cord-015684-q10sx1dm	736	5	of	of	IN
cord-015684-q10sx1dm	736	6	donepezil	donepezil	NNP
cord-015684-q10sx1dm	736	7	,	,	,
cord-015684-q10sx1dm	736	8	rivastigmine	rivastigmine	NNP
cord-015684-q10sx1dm	736	9	,	,	,
cord-015684-q10sx1dm	736	10	galantamine	galantamine	NNP
cord-015684-q10sx1dm	736	11	and	and	CC
cord-015684-q10sx1dm	736	12	memantine	memantine	NN
cord-015684-q10sx1dm	736	13	for	for	IN
cord-015684-q10sx1dm	736	14	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	736	15	's	's	POS
cord-015684-q10sx1dm	736	16	disease	disease	NN
cord-015684-q10sx1dm	736	17	Pharmacological	pharmacological	JJ
cord-015684-q10sx1dm	736	18	treatment	treatment	NN
cord-015684-q10sx1dm	736	19	of	of	IN
cord-015684-q10sx1dm	736	20	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	736	21	disease	disease	NN
cord-015684-q10sx1dm	736	22	:	:	:
cord-015684-q10sx1dm	736	23	from	from	IN
cord-015684-q10sx1dm	736	24	phychotropic	phychotropic	JJ
cord-015684-q10sx1dm	736	25	drugs	drug	NNS
cord-015684-q10sx1dm	736	26	and	and	CC
cord-015684-q10sx1dm	736	27	cholinesterase	cholinesterase	NN
cord-015684-q10sx1dm	736	28	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	736	29	to	to	IN
cord-015684-q10sx1dm	736	30	pharmacogenomics	pharmacogenomics	NNP
cord-015684-q10sx1dm	736	31	Pharmacogenomics	Pharmacogenomics	NNP
cord-015684-q10sx1dm	736	32	in	in	IN
cord-015684-q10sx1dm	736	33	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	736	34	's	's	POS
cord-015684-q10sx1dm	736	35	disease	disease	NN
cord-015684-q10sx1dm	736	36	Pharmacogenomics	Pharmacogenomics	NNP
cord-015684-q10sx1dm	736	37	for	for	IN
cord-015684-q10sx1dm	736	38	the	the	DT
cord-015684-q10sx1dm	736	39	treatment	treatment	NN
cord-015684-q10sx1dm	736	40	of	of	IN
cord-015684-q10sx1dm	736	41	dementia	dementia	NN
cord-015684-q10sx1dm	736	42	Pharmacogenetics	Pharmacogenetics	NNP
cord-015684-q10sx1dm	736	43	and	and	CC
cord-015684-q10sx1dm	736	44	drug	drug	NN
cord-015684-q10sx1dm	736	45	development	development	NN
cord-015684-q10sx1dm	736	46	:	:	:
cord-015684-q10sx1dm	736	47	the	the	DT
cord-015684-q10sx1dm	736	48	path	path	NN
cord-015684-q10sx1dm	736	49	to	to	IN
cord-015684-q10sx1dm	736	50	safer	safe	JJR
cord-015684-q10sx1dm	736	51	and	and	CC
cord-015684-q10sx1dm	736	52	more	more	RBR
cord-015684-q10sx1dm	736	53	effective	effective	JJ
cord-015684-q10sx1dm	736	54	drugs	drug	NNS
cord-015684-q10sx1dm	736	55	Molecular	molecular	JJ
cord-015684-q10sx1dm	736	56	genetics	genetic	NNS
cord-015684-q10sx1dm	736	57	of	of	IN
cord-015684-q10sx1dm	736	58	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	736	59	's	's	POS
cord-015684-q10sx1dm	736	60	disease	disease	NN
cord-015684-q10sx1dm	736	61	and	and	CC
cord-015684-q10sx1dm	736	62	aging	age	VBG
cord-015684-q10sx1dm	736	63	Molecular	molecular	JJ
cord-015684-q10sx1dm	736	64	genetics	genetic	NNS
cord-015684-q10sx1dm	736	65	of	of	IN
cord-015684-q10sx1dm	736	66	bipolar	bipolar	JJ
cord-015684-q10sx1dm	736	67	disorder	disorder	NN
cord-015684-q10sx1dm	736	68	and	and	CC
cord-015684-q10sx1dm	736	69	depression	depression	NN
cord-015684-q10sx1dm	736	70	Confounding	confound	VBG
cord-015684-q10sx1dm	736	71	in	in	IN
cord-015684-q10sx1dm	736	72	genetic	genetic	JJ
cord-015684-q10sx1dm	736	73	association	association	NN
cord-015684-q10sx1dm	736	74	studies	study	NNS
cord-015684-q10sx1dm	736	75	and	and	CC
cord-015684-q10sx1dm	736	76	its	-PRON-	PRP$
cord-015684-q10sx1dm	736	77	solutions	solution	NNS
cord-015684-q10sx1dm	736	78	Molecular	Molecular	NNP
cord-015684-q10sx1dm	736	79	genetics	genetic	NNS
cord-015684-q10sx1dm	736	80	of	of	IN
cord-015684-q10sx1dm	736	81	schizophrenia	schizophrenia	NNP
cord-015684-q10sx1dm	736	82	:	:	:
cord-015684-q10sx1dm	736	83	a	a	DT
cord-015684-q10sx1dm	736	84	critical	critical	JJ
cord-015684-q10sx1dm	736	85	review	review	NN
cord-015684-q10sx1dm	736	86	Lifespan	lifespan	NN
cord-015684-q10sx1dm	736	87	and	and	CC
cord-015684-q10sx1dm	736	88	mitochondrial	mitochondrial	JJ
cord-015684-q10sx1dm	736	89	control	control	NN
cord-015684-q10sx1dm	736	90	of	of	IN
cord-015684-q10sx1dm	736	91	neurodegeneration	neurodegeneration	NN
cord-015684-q10sx1dm	736	92	High	high	JJ
cord-015684-q10sx1dm	736	93	aggregate	aggregate	JJ
cord-015684-q10sx1dm	736	94	burden	burden	NN
cord-015684-q10sx1dm	736	95	of	of	IN
cord-015684-q10sx1dm	736	96	somatic	somatic	JJ
cord-015684-q10sx1dm	736	97	mtDNA	mtdna	NN
cord-015684-q10sx1dm	736	98	point	point	NN
cord-015684-q10sx1dm	736	99	mutations	mutation	NNS
cord-015684-q10sx1dm	736	100	in	in	IN
cord-015684-q10sx1dm	736	101	aging	age	VBG
cord-015684-q10sx1dm	736	102	and	and	CC
cord-015684-q10sx1dm	736	103	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	736	104	's	's	POS
cord-015684-q10sx1dm	736	105	disease	disease	NN
cord-015684-q10sx1dm	736	106	brain	brain	NN
cord-015684-q10sx1dm	737	1	The	the	DT
cord-015684-q10sx1dm	737	2	application	application	NN
cord-015684-q10sx1dm	737	3	of	of	IN
cord-015684-q10sx1dm	737	4	functional	functional	JJ
cord-015684-q10sx1dm	737	5	genomics	genomic	NNS
cord-015684-q10sx1dm	737	6	to	to	IN
cord-015684-q10sx1dm	737	7	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	737	8	's	's	POS
cord-015684-q10sx1dm	737	9	disease	disease	NN
cord-015684-q10sx1dm	737	10	Pharmacogenomics	Pharmacogenomics	NNPS
cord-015684-q10sx1dm	737	11	and	and	CC
cord-015684-q10sx1dm	737	12	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	737	13	prospects	prospect	NNS
cord-015684-q10sx1dm	737	14	in	in	IN
cord-015684-q10sx1dm	737	15	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	737	16	's	's	POS
cord-015684-q10sx1dm	737	17	disease	disease	NN
cord-015684-q10sx1dm	737	18	Pharmacogenomics	Pharmacogenomics	NNP
cord-015684-q10sx1dm	737	19	,	,	,
cord-015684-q10sx1dm	737	20	nutrigenomics	nutrigenomic	NNS
cord-015684-q10sx1dm	737	21	and	and	CC
cord-015684-q10sx1dm	737	22	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	737	23	optimization	optimization	NN
cord-015684-q10sx1dm	737	24	in	in	IN
cord-015684-q10sx1dm	737	25	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	737	26	's	's	POS
cord-015684-q10sx1dm	737	27	disease	disease	NN
cord-015684-q10sx1dm	737	28	Pharmacogenomics	Pharmacogenomics	NNP
cord-015684-q10sx1dm	737	29	,	,	,
cord-015684-q10sx1dm	737	30	nutrigenomics	nutrigenomic	NNS
cord-015684-q10sx1dm	737	31	and	and	CC
cord-015684-q10sx1dm	737	32	future	future	JJ
cord-015684-q10sx1dm	737	33	therapeutics	therapeutic	NNS
cord-015684-q10sx1dm	737	34	in	in	IN
cord-015684-q10sx1dm	737	35	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	737	36	's	's	POS
cord-015684-q10sx1dm	737	37	disease	disease	NN
cord-015684-q10sx1dm	737	38	Pharmacogenomics	Pharmacogenomics	NNP
cord-015684-q10sx1dm	737	39	in	in	IN
cord-015684-q10sx1dm	737	40	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	737	41	's	's	POS
cord-015684-q10sx1dm	737	42	disease	disease	NN
cord-015684-q10sx1dm	737	43	Cerebrovascular	cerebrovascular	JJ
cord-015684-q10sx1dm	737	44	risk	risk	NN
cord-015684-q10sx1dm	737	45	factors	factor	NNS
cord-015684-q10sx1dm	737	46	in	in	IN
cord-015684-q10sx1dm	737	47	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	737	48	's	's	POS
cord-015684-q10sx1dm	737	49	disease	disease	NN
cord-015684-q10sx1dm	737	50	:	:	:
cord-015684-q10sx1dm	737	51	brain	brain	NN
cord-015684-q10sx1dm	737	52	hemodynamics	hemodynamic	NNS
cord-015684-q10sx1dm	737	53	and	and	CC
cord-015684-q10sx1dm	737	54	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	737	55	implications	implication	NNS
cord-015684-q10sx1dm	738	1	Phenotypic	phenotypic	JJ
cord-015684-q10sx1dm	738	2	profi	profi	NNP
cord-015684-q10sx1dm	738	3	les	les	NNP
cord-015684-q10sx1dm	738	4	and	and	CC
cord-015684-q10sx1dm	738	5	functional	functional	JJ
cord-015684-q10sx1dm	738	6	genomics	genomic	NNS
cord-015684-q10sx1dm	738	7	in	in	IN
cord-015684-q10sx1dm	738	8	dementia	dementia	NN
cord-015684-q10sx1dm	738	9	with	with	IN
cord-015684-q10sx1dm	738	10	a	a	DT
cord-015684-q10sx1dm	738	11	vascular	vascular	JJ
cord-015684-q10sx1dm	738	12	component	component	NN
cord-015684-q10sx1dm	738	13	High	high	JJ
cord-015684-q10sx1dm	738	14	throughput	throughput	NN
cord-015684-q10sx1dm	738	15	protein	protein	NN
cord-015684-q10sx1dm	738	16	expression	expression	NN
cord-015684-q10sx1dm	738	17	screening	screening	NN
cord-015684-q10sx1dm	738	18	in	in	IN
cord-015684-q10sx1dm	738	19	the	the	DT
cord-015684-q10sx1dm	738	20	nervous	nervous	JJ
cord-015684-q10sx1dm	738	21	system	system	NN
cord-015684-q10sx1dm	738	22	-needs	-needs	HYPH
cord-015684-q10sx1dm	738	23	and	and	CC
cord-015684-q10sx1dm	738	24	limitations	limitation	NNS
cord-015684-q10sx1dm	738	25	Gene	Gene	NNP
cord-015684-q10sx1dm	738	26	expression	expression	NN
cord-015684-q10sx1dm	738	27	atlas	atlas	NN
cord-015684-q10sx1dm	738	28	of	of	IN
cord-015684-q10sx1dm	738	29	the	the	DT
cord-015684-q10sx1dm	738	30	mouse	mouse	NN
cord-015684-q10sx1dm	738	31	central	central	JJ
cord-015684-q10sx1dm	738	32	nervous	nervous	JJ
cord-015684-q10sx1dm	738	33	system	system	NN
cord-015684-q10sx1dm	738	34	:	:	:
cord-015684-q10sx1dm	739	1	impact	impact	NN
cord-015684-q10sx1dm	739	2	and	and	CC
cord-015684-q10sx1dm	739	3	interactions	interaction	NNS
cord-015684-q10sx1dm	739	4	of	of	IN
cord-015684-q10sx1dm	739	5	age	age	NN
cord-015684-q10sx1dm	739	6	,	,	,
cord-015684-q10sx1dm	739	7	energy	energy	NN
cord-015684-q10sx1dm	739	8	intake	intake	NN
cord-015684-q10sx1dm	739	9	and	and	CC
cord-015684-q10sx1dm	739	10	gender	gender	NN
cord-015684-q10sx1dm	739	11	Subtelomeric	Subtelomeric	NNP
cord-015684-q10sx1dm	739	12	study	study	NN
cord-015684-q10sx1dm	739	13	of	of	IN
cord-015684-q10sx1dm	739	14	132	132	CD
cord-015684-q10sx1dm	739	15	patients	patient	NNS
cord-015684-q10sx1dm	739	16	with	with	IN
cord-015684-q10sx1dm	739	17	mental	mental	JJ
cord-015684-q10sx1dm	739	18	retardation	retardation	NN
cord-015684-q10sx1dm	739	19	reveals	reveal	VBZ
cord-015684-q10sx1dm	739	20	9	9	CD
cord-015684-q10sx1dm	739	21	chromosomal	chromosomal	JJ
cord-015684-q10sx1dm	739	22	anomalies	anomaly	NNS
cord-015684-q10sx1dm	739	23	and	and	CC
cord-015684-q10sx1dm	739	24	contributes	contribute	VBZ
cord-015684-q10sx1dm	739	25	to	to	IN
cord-015684-q10sx1dm	739	26	the	the	DT
cord-015684-q10sx1dm	739	27	delineation	delineation	NN
cord-015684-q10sx1dm	739	28	of	of	IN
cord-015684-q10sx1dm	739	29	submicroscopic	submicroscopic	JJ
cord-015684-q10sx1dm	739	30	deletions	deletion	NNS
cord-015684-q10sx1dm	739	31	of	of	IN
cord-015684-q10sx1dm	739	32	1pter	1pter	CD
cord-015684-q10sx1dm	739	33	,	,	,
cord-015684-q10sx1dm	739	34	2qter	2qter	CD
cord-015684-q10sx1dm	739	35	,	,	,
cord-015684-q10sx1dm	739	36	4pter	4pter	CD
cord-015684-q10sx1dm	739	37	,	,	,
cord-015684-q10sx1dm	739	38	5qter	5qter	CD
cord-015684-q10sx1dm	739	39	and	and	CC
cord-015684-q10sx1dm	739	40	9qter	9qter	CD
cord-015684-q10sx1dm	739	41	DNA	dna	NN
cord-015684-q10sx1dm	739	42	fragmentation	fragmentation	NN
cord-015684-q10sx1dm	739	43	is	be	VBZ
cord-015684-q10sx1dm	739	44	increased	increase	VBN
cord-015684-q10sx1dm	739	45	in	in	IN
cord-015684-q10sx1dm	739	46	non	non	JJ
cord-015684-q10sx1dm	739	47	-	-	JJ
cord-015684-q10sx1dm	739	48	GABAergic	gabaergic	JJ
cord-015684-q10sx1dm	739	49	neurons	neuron	NNS
cord-015684-q10sx1dm	739	50	in	in	IN
cord-015684-q10sx1dm	739	51	bipolar	bipolar	JJ
cord-015684-q10sx1dm	739	52	disorder	disorder	NN
cord-015684-q10sx1dm	739	53	but	but	CC
cord-015684-q10sx1dm	739	54	not	not	RB
cord-015684-q10sx1dm	739	55	in	in	IN
cord-015684-q10sx1dm	739	56	schizophrenia	schizophrenia	NNP
cord-015684-q10sx1dm	740	1	The	the	DT
cord-015684-q10sx1dm	740	2	functional	functional	JJ
cord-015684-q10sx1dm	740	3	genome	genome	NN
cord-015684-q10sx1dm	740	4	of	of	IN
cord-015684-q10sx1dm	740	5	CA1	CA1	NNP
cord-015684-q10sx1dm	740	6	and	and	CC
cord-015684-q10sx1dm	740	7	CA3	CA3	NNP
cord-015684-q10sx1dm	740	8	neurons	neuron	NNS
cord-015684-q10sx1dm	740	9	under	under	IN
cord-015684-q10sx1dm	740	10	native	native	JJ
cord-015684-q10sx1dm	740	11	conditions	condition	NNS
cord-015684-q10sx1dm	740	12	and	and	CC
cord-015684-q10sx1dm	740	13	in	in	IN
cord-015684-q10sx1dm	740	14	response	response	NN
cord-015684-q10sx1dm	740	15	to	to	IN
cord-015684-q10sx1dm	740	16	ischemia	ischemia	NN
cord-015684-q10sx1dm	740	17	Fibroblast	Fibroblast	NNP
cord-015684-q10sx1dm	740	18	and	and	CC
cord-015684-q10sx1dm	740	19	lymphoblast	lymphoblast	NNP
cord-015684-q10sx1dm	740	20	gene	gene	NN
cord-015684-q10sx1dm	740	21	expression	expression	NN
cord-015684-q10sx1dm	740	22	profi	profi	NNP
cord-015684-q10sx1dm	740	23	les	les	NNP
cord-015684-q10sx1dm	740	24	in	in	IN
cord-015684-q10sx1dm	740	25	schizophrenia	schizophrenia	NNP
cord-015684-q10sx1dm	740	26	:	:	:
cord-015684-q10sx1dm	740	27	are	be	VBP
cord-015684-q10sx1dm	740	28	non	non	JJ
cord-015684-q10sx1dm	740	29	-	-	JJ
cord-015684-q10sx1dm	740	30	neural	neural	JJ
cord-015684-q10sx1dm	740	31	cells	cell	NNS
cord-015684-q10sx1dm	740	32	informative	informative	JJ
cord-015684-q10sx1dm	740	33	?	?	.
cord-015684-q10sx1dm	741	1	Runs	run	NNS
cord-015684-q10sx1dm	741	2	of	of	IN
cord-015684-q10sx1dm	741	3	homozygosity	homozygosity	NN
cord-015684-q10sx1dm	741	4	reveal	reveal	VB
cord-015684-q10sx1dm	741	5	highly	highly	RB
cord-015684-q10sx1dm	741	6	penetrant	penetrant	JJ
cord-015684-q10sx1dm	741	7	recessive	recessive	JJ
cord-015684-q10sx1dm	741	8	loci	locus	NNS
cord-015684-q10sx1dm	741	9	in	in	IN
cord-015684-q10sx1dm	741	10	schizophrenia	schizophrenia	NNP
cord-015684-q10sx1dm	742	1	The	the	DT
cord-015684-q10sx1dm	742	2	use	use	NN
cord-015684-q10sx1dm	742	3	of	of	IN
cord-015684-q10sx1dm	742	4	microarrays	microarray	NNS
cord-015684-q10sx1dm	742	5	to	to	TO
cord-015684-q10sx1dm	742	6	characterize	characterize	VB
cord-015684-q10sx1dm	742	7	neuropsychiatric	neuropsychiatric	JJ
cord-015684-q10sx1dm	742	8	disorders	disorder	NNS
cord-015684-q10sx1dm	742	9	:	:	:
cord-015684-q10sx1dm	742	10	post	post	JJ
cord-015684-q10sx1dm	742	11	-	-	JJ
cord-015684-q10sx1dm	742	12	mortem	mortem	JJ
cord-015684-q10sx1dm	742	13	studies	study	NNS
cord-015684-q10sx1dm	742	14	of	of	IN
cord-015684-q10sx1dm	742	15	substance	substance	NN
cord-015684-q10sx1dm	742	16	abuse	abuse	NN
cord-015684-q10sx1dm	742	17	and	and	CC
cord-015684-q10sx1dm	742	18	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	742	19	High	high	JJ
cord-015684-q10sx1dm	742	20	-	-	HYPH
cord-015684-q10sx1dm	742	21	throughput	throughput	NN
cord-015684-q10sx1dm	742	22	analysis	analysis	NN
cord-015684-q10sx1dm	742	23	of	of	IN
cord-015684-q10sx1dm	742	24	promoter	promoter	NN
cord-015684-q10sx1dm	742	25	occupancy	occupancy	NN
cord-015684-q10sx1dm	742	26	reveals	reveal	VBZ
cord-015684-q10sx1dm	742	27	direct	direct	JJ
cord-015684-q10sx1dm	742	28	neuronal	neuronal	JJ
cord-015684-q10sx1dm	742	29	targets	target	NNS
cord-015684-q10sx1dm	742	30	of	of	IN
cord-015684-q10sx1dm	742	31	FOXP2	FOXP2	NNP
cord-015684-q10sx1dm	742	32	,	,	,
cord-015684-q10sx1dm	742	33	a	a	DT
cord-015684-q10sx1dm	742	34	gene	gene	NN
cord-015684-q10sx1dm	742	35	mutated	mutate	VBN
cord-015684-q10sx1dm	742	36	in	in	IN
cord-015684-q10sx1dm	742	37	speech	speech	NN
cord-015684-q10sx1dm	742	38	and	and	CC
cord-015684-q10sx1dm	742	39	language	language	NN
cord-015684-q10sx1dm	742	40	disorders	disorder	NNS
cord-015684-q10sx1dm	742	41	Microarray	Microarray	NNP
cord-015684-q10sx1dm	742	42	analysis	analysis	NN
cord-015684-q10sx1dm	742	43	of	of	IN
cord-015684-q10sx1dm	742	44	oxidative	oxidative	JJ
cord-015684-q10sx1dm	742	45	stress	stress	NN
cord-015684-q10sx1dm	742	46	regulated	regulate	VBN
cord-015684-q10sx1dm	742	47	genes	gene	NNS
cord-015684-q10sx1dm	742	48	in	in	IN
cord-015684-q10sx1dm	742	49	mesencephalic	mesencephalic	JJ
cord-015684-q10sx1dm	742	50	dopaminergic	dopaminergic	JJ
cord-015684-q10sx1dm	742	51	neuronal	neuronal	JJ
cord-015684-q10sx1dm	742	52	cells	cell	NNS
cord-015684-q10sx1dm	742	53	:	:	:
cord-015684-q10sx1dm	742	54	relevance	relevance	NN
cord-015684-q10sx1dm	742	55	to	to	IN
cord-015684-q10sx1dm	742	56	oxidative	oxidative	JJ
cord-015684-q10sx1dm	742	57	damage	damage	NN
cord-015684-q10sx1dm	742	58	in	in	IN
cord-015684-q10sx1dm	742	59	Parkinson	Parkinson	NNP
cord-015684-q10sx1dm	742	60	's	's	POS
cord-015684-q10sx1dm	742	61	disease	disease	NN
cord-015684-q10sx1dm	742	62	Towards	towards	IN
cord-015684-q10sx1dm	742	63	a	a	DT
cord-015684-q10sx1dm	742	64	pathway	pathway	NN
cord-015684-q10sx1dm	742	65	defi	defi	IN
cord-015684-q10sx1dm	742	66	nition	nition	NN
cord-015684-q10sx1dm	742	67	of	of	IN
cord-015684-q10sx1dm	742	68	Parkinson	Parkinson	NNP
cord-015684-q10sx1dm	742	69	's	's	POS
cord-015684-q10sx1dm	742	70	disease	disease	NN
cord-015684-q10sx1dm	742	71	:	:	:
cord-015684-q10sx1dm	742	72	a	a	DT
cord-015684-q10sx1dm	742	73	complex	complex	JJ
cord-015684-q10sx1dm	742	74	disorder	disorder	NN
cord-015684-q10sx1dm	742	75	with	with	IN
cord-015684-q10sx1dm	742	76	links	link	NNS
cord-015684-q10sx1dm	742	77	to	to	IN
cord-015684-q10sx1dm	742	78	cancer	cancer	NN
cord-015684-q10sx1dm	742	79	,	,	,
cord-015684-q10sx1dm	742	80	diabetes	diabetes	NN
cord-015684-q10sx1dm	742	81	and	and	CC
cord-015684-q10sx1dm	742	82	infl	infl	NNP
cord-015684-q10sx1dm	742	83	ammation	ammation	NNP
cord-015684-q10sx1dm	742	84	Analysis	Analysis	NNP
cord-015684-q10sx1dm	742	85	of	of	IN
cord-015684-q10sx1dm	742	86	potential	potential	JJ
cord-015684-q10sx1dm	742	87	transcriptomic	transcriptomic	JJ
cord-015684-q10sx1dm	742	88	biomarkers	biomarker	NNS
cord-015684-q10sx1dm	742	89	for	for	IN
cord-015684-q10sx1dm	742	90	Huntington	Huntington	NNP
cord-015684-q10sx1dm	742	91	's	's	POS
cord-015684-q10sx1dm	742	92	disease	disease	NN
cord-015684-q10sx1dm	742	93	in	in	IN
cord-015684-q10sx1dm	742	94	peripheral	peripheral	JJ
cord-015684-q10sx1dm	742	95	blood	blood	NN
cord-015684-q10sx1dm	742	96	Comprehensive	Comprehensive	NNP
cord-015684-q10sx1dm	742	97	transcriptional	transcriptional	JJ
cord-015684-q10sx1dm	742	98	profi	profi	NNP
cord-015684-q10sx1dm	742	99	ling	ling	NNP
cord-015684-q10sx1dm	742	100	of	of	IN
cord-015684-q10sx1dm	742	101	prion	prion	NN
cord-015684-q10sx1dm	742	102	infection	infection	NN
cord-015684-q10sx1dm	742	103	in	in	IN
cord-015684-q10sx1dm	742	104	mouse	mouse	NN
cord-015684-q10sx1dm	742	105	models	model	NNS
cord-015684-q10sx1dm	742	106	reveals	reveal	VBZ
cord-015684-q10sx1dm	742	107	networks	network	NNS
cord-015684-q10sx1dm	742	108	of	of	IN
cord-015684-q10sx1dm	742	109	responsive	responsive	JJ
cord-015684-q10sx1dm	742	110	genes	gene	NNS
cord-015684-q10sx1dm	742	111	Transcriptional	Transcriptional	NNP
cord-015684-q10sx1dm	742	112	profi	profi	NNP
cord-015684-q10sx1dm	742	113	ling	ling	NNP
cord-015684-q10sx1dm	742	114	in	in	IN
cord-015684-q10sx1dm	742	115	the	the	DT
cord-015684-q10sx1dm	742	116	human	human	JJ
cord-015684-q10sx1dm	742	117	prefrontal	prefrontal	JJ
cord-015684-q10sx1dm	742	118	cortex	cortex	NN
cord-015684-q10sx1dm	742	119	:	:	:
cord-015684-q10sx1dm	742	120	evidence	evidence	NN
cord-015684-q10sx1dm	742	121	for	for	IN
cord-015684-q10sx1dm	742	122	two	two	CD
cord-015684-q10sx1dm	742	123	activational	activational	JJ
cord-015684-q10sx1dm	742	124	states	state	NNS
cord-015684-q10sx1dm	742	125	with	with	IN
cord-015684-q10sx1dm	742	126	cocaine	cocaine	NN
cord-015684-q10sx1dm	742	127	abuse	abuse	NN
cord-015684-q10sx1dm	742	128	Gene	Gene	NNP
cord-015684-q10sx1dm	742	129	expression	expression	NN
cord-015684-q10sx1dm	742	130	profi	profi	NNP
cord-015684-q10sx1dm	742	131	ling	ling	NNP
cord-015684-q10sx1dm	742	132	in	in	IN
cord-015684-q10sx1dm	742	133	the	the	DT
cord-015684-q10sx1dm	742	134	brains	brain	NNS
cord-015684-q10sx1dm	742	135	of	of	IN
cord-015684-q10sx1dm	742	136	human	human	JJ
cord-015684-q10sx1dm	742	137	cocaine	cocaine	NN
cord-015684-q10sx1dm	742	138	abusers	abuser	NNS
cord-015684-q10sx1dm	742	139	Ethanol	ethanol	NN
cord-015684-q10sx1dm	742	140	and	and	CC
cord-015684-q10sx1dm	742	141	brain	brain	NN
cord-015684-q10sx1dm	742	142	damage	damage	NN
cord-015684-q10sx1dm	743	1	Genomic	genomic	JJ
cord-015684-q10sx1dm	743	2	responses	response	NNS
cord-015684-q10sx1dm	743	3	in	in	IN
cord-015684-q10sx1dm	743	4	rat	rat	NN
cord-015684-q10sx1dm	743	5	cerebral	cerebral	JJ
cord-015684-q10sx1dm	743	6	cortex	cortex	NN
cord-015684-q10sx1dm	743	7	after	after	IN
cord-015684-q10sx1dm	743	8	traumatic	traumatic	JJ
cord-015684-q10sx1dm	743	9	injury	injury	NN
cord-015684-q10sx1dm	743	10	Transcriptional	Transcriptional	NNP
cord-015684-q10sx1dm	743	11	profi	profi	NNP
cord-015684-q10sx1dm	743	12	ling	ling	NNP
cord-015684-q10sx1dm	743	13	in	in	IN
cord-015684-q10sx1dm	743	14	human	human	JJ
cord-015684-q10sx1dm	743	15	epilepsy	epilepsy	NN
cord-015684-q10sx1dm	743	16	:	:	:
cord-015684-q10sx1dm	743	17	expression	expression	NN
cord-015684-q10sx1dm	743	18	array	array	NN
cord-015684-q10sx1dm	743	19	and	and	CC
cord-015684-q10sx1dm	743	20	single	single	JJ
cord-015684-q10sx1dm	743	21	cell	cell	NN
cord-015684-q10sx1dm	743	22	real	real	JJ
cord-015684-q10sx1dm	743	23	-	-	HYPH
cord-015684-q10sx1dm	743	24	time	time	NN
cord-015684-q10sx1dm	743	25	qRT	qRT	NNP
cord-015684-q10sx1dm	743	26	-	-	HYPH
cord-015684-q10sx1dm	743	27	PCR	PCR	NNP
cord-015684-q10sx1dm	743	28	analysis	analysis	NN
cord-015684-q10sx1dm	743	29	reveal	reveal	VBP
cord-015684-q10sx1dm	743	30	distinct	distinct	JJ
cord-015684-q10sx1dm	743	31	cellular	cellular	JJ
cord-015684-q10sx1dm	743	32	gene	gene	NN
cord-015684-q10sx1dm	743	33	regulation	regulation	NN
cord-015684-q10sx1dm	743	34	Molecular	Molecular	NNP
cord-015684-q10sx1dm	743	35	profi	profi	NNP
cord-015684-q10sx1dm	743	36	ling	ling	NNP
cord-015684-q10sx1dm	743	37	of	of	IN
cord-015684-q10sx1dm	743	38	temporal	temporal	JJ
cord-015684-q10sx1dm	743	39	lobe	lobe	NNP
cord-015684-q10sx1dm	743	40	epilepsy	epilepsy	NN
cord-015684-q10sx1dm	743	41	:	:	:
cord-015684-q10sx1dm	743	42	comparison	comparison	NN
cord-015684-q10sx1dm	743	43	of	of	IN
cord-015684-q10sx1dm	743	44	data	datum	NNS
cord-015684-q10sx1dm	743	45	from	from	IN
cord-015684-q10sx1dm	743	46	human	human	JJ
cord-015684-q10sx1dm	743	47	tissue	tissue	NN
cord-015684-q10sx1dm	743	48	and	and	CC
cord-015684-q10sx1dm	743	49	animal	animal	NN
cord-015684-q10sx1dm	743	50	models	model	NNS
cord-015684-q10sx1dm	744	1	The	the	DT
cord-015684-q10sx1dm	744	2	antiepileptic	antiepileptic	JJ
cord-015684-q10sx1dm	744	3	drug	drug	NN
cord-015684-q10sx1dm	744	4	levetiracetam	levetiracetam	NNS
cord-015684-q10sx1dm	744	5	selectively	selectively	RB
cord-015684-q10sx1dm	744	6	modifi	modifi	VBP
cord-015684-q10sx1dm	744	7	es	es	XX
cord-015684-q10sx1dm	744	8	kindling	kindling	NN
cord-015684-q10sx1dm	744	9	-	-	HYPH
cord-015684-q10sx1dm	744	10	induced	induce	VBN
cord-015684-q10sx1dm	744	11	alterations	alteration	NNS
cord-015684-q10sx1dm	744	12	in	in	IN
cord-015684-q10sx1dm	744	13	gene	gene	NN
cord-015684-q10sx1dm	744	14	expression	expression	NN
cord-015684-q10sx1dm	744	15	in	in	IN
cord-015684-q10sx1dm	744	16	the	the	DT
cord-015684-q10sx1dm	744	17	temporal	temporal	JJ
cord-015684-q10sx1dm	744	18	lobe	lobe	NN
cord-015684-q10sx1dm	744	19	of	of	IN
cord-015684-q10sx1dm	744	20	rats	rat	NNS
cord-015684-q10sx1dm	744	21	Increased	increase	VBD
cord-015684-q10sx1dm	744	22	apoptosis	apoptosis	NN
cord-015684-q10sx1dm	744	23	,	,	,
cord-015684-q10sx1dm	744	24	p53	p53	VBP
cord-015684-q10sx1dm	744	25	up	up	IN
cord-015684-q10sx1dm	744	26	-	-	HYPH
cord-015684-q10sx1dm	744	27	regulation	regulation	NN
cord-015684-q10sx1dm	744	28	,	,	,
cord-015684-q10sx1dm	744	29	and	and	CC
cord-015684-q10sx1dm	744	30	cerebellar	cerebellar	JJ
cord-015684-q10sx1dm	744	31	neuronal	neuronal	JJ
cord-015684-q10sx1dm	744	32	degeneration	degeneration	NN
cord-015684-q10sx1dm	744	33	in	in	IN
cord-015684-q10sx1dm	744	34	repair	repair	NN
cord-015684-q10sx1dm	744	35	-	-	HYPH
cord-015684-q10sx1dm	744	36	defi	defi	NN
cord-015684-q10sx1dm	744	37	cient	cient	NNP
cord-015684-q10sx1dm	744	38	Cockayne	Cockayne	NNP
cord-015684-q10sx1dm	744	39	syndrome	syndrome	NN
cord-015684-q10sx1dm	744	40	mice	mouse	NNS
cord-015684-q10sx1dm	744	41	Inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	744	42	of	of	IN
cord-015684-q10sx1dm	744	43	differentiation	differentiation	NN
cord-015684-q10sx1dm	745	1	(	(	-LRB-
cord-015684-q10sx1dm	745	2	ID1	ID1	NNP
cord-015684-q10sx1dm	745	3	,	,	,
cord-015684-q10sx1dm	745	4	ID2	ID2	NNP
cord-015684-q10sx1dm	745	5	,	,	,
cord-015684-q10sx1dm	745	6	ID3	ID3	NNP
cord-015684-q10sx1dm	745	7	and	and	CC
cord-015684-q10sx1dm	745	8	ID4	ID4	NNP
cord-015684-q10sx1dm	745	9	)	)	-RRB-
cord-015684-q10sx1dm	745	10	genes	gene	NNS
cord-015684-q10sx1dm	745	11	are	be	VBP
cord-015684-q10sx1dm	745	12	neuronal	neuronal	JJ
cord-015684-q10sx1dm	745	13	targets	target	NNS
cord-015684-q10sx1dm	745	14	of	of	IN
cord-015684-q10sx1dm	745	15	MeCP2	mecp2	NN
cord-015684-q10sx1dm	745	16	that	that	WDT
cord-015684-q10sx1dm	745	17	are	be	VBP
cord-015684-q10sx1dm	745	18	elevated	elevate	VBN
cord-015684-q10sx1dm	745	19	in	in	IN
cord-015684-q10sx1dm	745	20	Rett	Rett	NNP
cord-015684-q10sx1dm	745	21	síndrome	síndrome	NNP
cord-015684-q10sx1dm	745	22	HDAC	HDAC	NNP
cord-015684-q10sx1dm	745	23	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	746	1	correct	correct	JJ
cord-015684-q10sx1dm	746	2	frataxin	frataxin	NNP
cord-015684-q10sx1dm	746	3	defi	defi	NNP
cord-015684-q10sx1dm	746	4	ciency	ciency	NNP
cord-015684-q10sx1dm	746	5	in	in	IN
cord-015684-q10sx1dm	746	6	a	a	DT
cord-015684-q10sx1dm	746	7	Friedreich	Friedreich	NNP
cord-015684-q10sx1dm	746	8	ataxia	ataxia	NN
cord-015684-q10sx1dm	746	9	mouse	mouse	NN
cord-015684-q10sx1dm	746	10	model	model	NN
cord-015684-q10sx1dm	746	11	Gene	Gene	NNP
cord-015684-q10sx1dm	746	12	expression	expression	NN
cord-015684-q10sx1dm	746	13	profi	profi	NNP
cord-015684-q10sx1dm	746	14	ling	ling	NNP
cord-015684-q10sx1dm	746	15	in	in	IN
cord-015684-q10sx1dm	746	16	a	a	DT
cord-015684-q10sx1dm	746	17	Mouse	Mouse	NNP
cord-015684-q10sx1dm	746	18	model	model	NN
cord-015684-q10sx1dm	746	19	of	of	IN
cord-015684-q10sx1dm	746	20	infantile	infantile	JJ
cord-015684-q10sx1dm	746	21	neuronal	neuronal	JJ
cord-015684-q10sx1dm	746	22	lipofuscinosis	lipofuscinosis	NN
cord-015684-q10sx1dm	747	1	reveals	reveal	VBZ
cord-015684-q10sx1dm	747	2	upregulation	upregulation	NN
cord-015684-q10sx1dm	747	3	of	of	IN
cord-015684-q10sx1dm	747	4	immediate	immediate	JJ
cord-015684-q10sx1dm	747	5	early	early	JJ
cord-015684-q10sx1dm	747	6	genes	gene	NNS
cord-015684-q10sx1dm	747	7	and	and	CC
cord-015684-q10sx1dm	747	8	mediators	mediator	NNS
cord-015684-q10sx1dm	747	9	of	of	IN
cord-015684-q10sx1dm	747	10	the	the	DT
cord-015684-q10sx1dm	747	11	infl	infl	NNP
cord-015684-q10sx1dm	747	12	ammatory	ammatory	NNP
cord-015684-q10sx1dm	747	13	response	response	NN
cord-015684-q10sx1dm	747	14	Multiple	multiple	JJ
cord-015684-q10sx1dm	747	15	sclerosis	sclerosis	NN
cord-015684-q10sx1dm	747	16	as	as	IN
cord-015684-q10sx1dm	747	17	a	a	DT
cord-015684-q10sx1dm	747	18	generalized	generalized	JJ
cord-015684-q10sx1dm	747	19	CNS	CNS	NNP
cord-015684-q10sx1dm	747	20	disease	disease	NN
cord-015684-q10sx1dm	747	21	-comparative	-comparative	NN
cord-015684-q10sx1dm	747	22	microarray	microarray	NN
cord-015684-q10sx1dm	747	23	analysis	analysis	NN
cord-015684-q10sx1dm	747	24	of	of	IN
cord-015684-q10sx1dm	747	25	normal	normal	JJ
cord-015684-q10sx1dm	747	26	appearing	appear	VBG
cord-015684-q10sx1dm	747	27	white	white	JJ
cord-015684-q10sx1dm	747	28	matter	matter	NN
cord-015684-q10sx1dm	747	29	and	and	CC
cord-015684-q10sx1dm	747	30	lesions	lesion	NNS
cord-015684-q10sx1dm	747	31	in	in	IN
cord-015684-q10sx1dm	747	32	secondary	secondary	JJ
cord-015684-q10sx1dm	747	33	progressive	progressive	JJ
cord-015684-q10sx1dm	747	34	MS	MS	NNP
cord-015684-q10sx1dm	747	35	Pathways	Pathways	NNPS
cord-015684-q10sx1dm	747	36	and	and	CC
cord-015684-q10sx1dm	747	37	genes	gene	NNS
cord-015684-q10sx1dm	747	38	differentially	differentially	RB
cord-015684-q10sx1dm	747	39	expressed	express	VBN
cord-015684-q10sx1dm	747	40	in	in	IN
cord-015684-q10sx1dm	747	41	the	the	DT
cord-015684-q10sx1dm	747	42	motor	motor	NN
cord-015684-q10sx1dm	747	43	cortex	cortex	NN
cord-015684-q10sx1dm	747	44	of	of	IN
cord-015684-q10sx1dm	747	45	patients	patient	NNS
cord-015684-q10sx1dm	747	46	with	with	IN
cord-015684-q10sx1dm	747	47	sporadic	sporadic	JJ
cord-015684-q10sx1dm	747	48	amyotrophic	amyotrophic	JJ
cord-015684-q10sx1dm	747	49	lateral	lateral	JJ
cord-015684-q10sx1dm	747	50	sclerosis	sclerosis	NN
cord-015684-q10sx1dm	747	51	Gene	Gene	NNP
cord-015684-q10sx1dm	747	52	expression	expression	NN
cord-015684-q10sx1dm	747	53	in	in	IN
cord-015684-q10sx1dm	747	54	cortex	cortex	NN
cord-015684-q10sx1dm	747	55	and	and	CC
cord-015684-q10sx1dm	747	56	hippocampus	hippocampus	NN
cord-015684-q10sx1dm	747	57	during	during	IN
cord-015684-q10sx1dm	747	58	acute	acute	JJ
cord-015684-q10sx1dm	747	59	pneumococcal	pneumococcal	JJ
cord-015684-q10sx1dm	747	60	meningitis	meningitis	NN
cord-015684-q10sx1dm	747	61	Role	role	NN
cord-015684-q10sx1dm	747	62	of	of	IN
cord-015684-q10sx1dm	747	63	lipids	lipid	NNS
cord-015684-q10sx1dm	747	64	in	in	IN
cord-015684-q10sx1dm	747	65	brain	brain	NN
cord-015684-q10sx1dm	747	66	injury	injury	NN
cord-015684-q10sx1dm	747	67	and	and	CC
cord-015684-q10sx1dm	747	68	diseases	disease	NNS
cord-015684-q10sx1dm	747	69	Expression	Expression	NNP
cord-015684-q10sx1dm	747	70	profi	profi	NNP
cord-015684-q10sx1dm	747	71	le	le	NNP
cord-015684-q10sx1dm	747	72	analysis	analysis	NN
cord-015684-q10sx1dm	747	73	of	of	IN
cord-015684-q10sx1dm	747	74	neurodegenerative	neurodegenerative	JJ
cord-015684-q10sx1dm	747	75	disease	disease	NN
cord-015684-q10sx1dm	747	76	:	:	:
cord-015684-q10sx1dm	747	77	advances	advance	NNS
cord-015684-q10sx1dm	747	78	in	in	IN
cord-015684-q10sx1dm	747	79	specifi	specifi	NN
cord-015684-q10sx1dm	747	80	city	city	NN
cord-015684-q10sx1dm	747	81	and	and	CC
cord-015684-q10sx1dm	747	82	resolution	resolution	NN
cord-015684-q10sx1dm	747	83	Methodological	methodological	JJ
cord-015684-q10sx1dm	747	84	considerations	consideration	NNS
cord-015684-q10sx1dm	747	85	regarding	regard	VBG
cord-015684-q10sx1dm	747	86	single	single	JJ
cord-015684-q10sx1dm	747	87	-	-	HYPH
cord-015684-q10sx1dm	747	88	cell	cell	NN
cord-015684-q10sx1dm	747	89	gene	gene	NN
cord-015684-q10sx1dm	747	90	expression	expression	NN
cord-015684-q10sx1dm	747	91	profi	profi	NNP
cord-015684-q10sx1dm	747	92	ling	ling	NNP
cord-015684-q10sx1dm	747	93	for	for	IN
cord-015684-q10sx1dm	747	94	brain	brain	NN
cord-015684-q10sx1dm	747	95	injury	injury	NN
cord-015684-q10sx1dm	747	96	Genotoxicants	Genotoxicants	NNP
cord-015684-q10sx1dm	748	1	target	target	VB
cord-015684-q10sx1dm	748	2	distinct	distinct	JJ
cord-015684-q10sx1dm	748	3	molecular	molecular	JJ
cord-015684-q10sx1dm	748	4	networks	network	NNS
cord-015684-q10sx1dm	748	5	in	in	IN
cord-015684-q10sx1dm	748	6	neonatal	neonatal	JJ
cord-015684-q10sx1dm	748	7	neurons	neuron	NNS
cord-015684-q10sx1dm	749	1	Functional	functional	JJ
cord-015684-q10sx1dm	749	2	gene	gene	NN
cord-015684-q10sx1dm	749	3	expression	expression	NN
cord-015684-q10sx1dm	749	4	differences	difference	NNS
cord-015684-q10sx1dm	749	5	between	between	IN
cord-015684-q10sx1dm	749	6	inbred	inbred	JJ
cord-015684-q10sx1dm	749	7	alcohol	alcohol	NN
cord-015684-q10sx1dm	749	8	-	-	HYPH
cord-015684-q10sx1dm	749	9	preferring	preferring	NN
cord-015684-q10sx1dm	749	10	and	and	CC
cord-015684-q10sx1dm	749	11	-non	-non	ADD
cord-015684-q10sx1dm	749	12	-	-	:
cord-015684-q10sx1dm	749	13	prerats	prerat	NNS
cord-015684-q10sx1dm	749	14	in	in	IN
cord-015684-q10sx1dm	749	15	fi	fi	NNP
cord-015684-q10sx1dm	749	16	ve	ve	NNP
cord-015684-q10sx1dm	749	17	brain	brain	NN
cord-015684-q10sx1dm	749	18	regions	region	NNS
cord-015684-q10sx1dm	749	19	Neuroadaptations	Neuroadaptations	NNPS
cord-015684-q10sx1dm	749	20	in	in	IN
cord-015684-q10sx1dm	749	21	human	human	JJ
cord-015684-q10sx1dm	749	22	chronic	chronic	JJ
cord-015684-q10sx1dm	749	23	alcoholics	alcoholic	NNS
cord-015684-q10sx1dm	749	24	:	:	:
cord-015684-q10sx1dm	749	25	tion	tion	NN
cord-015684-q10sx1dm	749	26	of	of	IN
cord-015684-q10sx1dm	749	27	the	the	DT
cord-015684-q10sx1dm	749	28	NF	nf	NN
cord-015684-q10sx1dm	749	29	-	-	HYPH
cord-015684-q10sx1dm	749	30	κB	κb	CD
cord-015684-q10sx1dm	749	31	system	system	NN
cord-015684-q10sx1dm	749	32	Gene	Gene	NNP
cord-015684-q10sx1dm	749	33	expression	expression	NN
cord-015684-q10sx1dm	749	34	profi	profi	NNP
cord-015684-q10sx1dm	749	35	le	le	NNP
cord-015684-q10sx1dm	749	36	of	of	IN
cord-015684-q10sx1dm	749	37	the	the	DT
cord-015684-q10sx1dm	749	38	nucleus	nucleus	NN
cord-015684-q10sx1dm	749	39	accumbens	accumben	NNS
cord-015684-q10sx1dm	749	40	of	of	IN
cord-015684-q10sx1dm	749	41	human	human	JJ
cord-015684-q10sx1dm	749	42	cocaine	cocaine	NN
cord-015684-q10sx1dm	749	43	abusers	abuser	NNS
cord-015684-q10sx1dm	749	44	:	:	:
cord-015684-q10sx1dm	749	45	evidence	evidence	NN
cord-015684-q10sx1dm	749	46	for	for	IN
cord-015684-q10sx1dm	749	47	dysregulation	dysregulation	NN
cord-015684-q10sx1dm	749	48	of	of	IN
cord-015684-q10sx1dm	749	49	myelin	myelin	NN
cord-015684-q10sx1dm	749	50	Transcriptional	Transcriptional	NNP
cord-015684-q10sx1dm	749	51	changes	change	VBZ
cord-015684-q10sx1dm	749	52	common	common	JJ
cord-015684-q10sx1dm	749	53	to	to	IN
cord-015684-q10sx1dm	749	54	human	human	JJ
cord-015684-q10sx1dm	749	55	cocaine	cocaine	NN
cord-015684-q10sx1dm	749	56	,	,	,
cord-015684-q10sx1dm	749	57	cannabis	cannabis	NN
cord-015684-q10sx1dm	749	58	and	and	CC
cord-015684-q10sx1dm	749	59	phencyclidine	phencyclidine	NN
cord-015684-q10sx1dm	749	60	abuse	abuse	NN
cord-015684-q10sx1dm	749	61	MicroRNA	MicroRNA	NNP
cord-015684-q10sx1dm	749	62	expression	expression	NN
cord-015684-q10sx1dm	749	63	in	in	IN
cord-015684-q10sx1dm	749	64	the	the	DT
cord-015684-q10sx1dm	749	65	adult	adult	NN
cord-015684-q10sx1dm	749	66	mouse	mouse	NN
cord-015684-q10sx1dm	749	67	central	central	JJ
cord-015684-q10sx1dm	749	68	nervous	nervous	JJ
cord-015684-q10sx1dm	749	69	system	system	NN
cord-015684-q10sx1dm	750	1	A	a	DT
cord-015684-q10sx1dm	750	2	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	750	3	approach	approach	NN
cord-015684-q10sx1dm	750	4	to	to	IN
cord-015684-q10sx1dm	750	5	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	750	6	's	's	POS
cord-015684-q10sx1dm	750	7	disease	disease	NN
cord-015684-q10sx1dm	750	8	Clinical	Clinical	NNP
cord-015684-q10sx1dm	750	9	Psychiatry	Psychiatry	NNP
cord-015684-q10sx1dm	750	10	.	.	.
cord-015684-q10sx1dm	751	1	Jobe	Jobe	NNP
cord-015684-q10sx1dm	751	2	TH	TH	NNP
cord-015684-q10sx1dm	751	3	Genomics	Genomics	NNPS
cord-015684-q10sx1dm	751	4	and	and	CC
cord-015684-q10sx1dm	751	5	phenotypic	phenotypic	JJ
cord-015684-q10sx1dm	751	6	profi	profi	NNP
cord-015684-q10sx1dm	751	7	les	les	NNP
cord-015684-q10sx1dm	751	8	in	in	IN
cord-015684-q10sx1dm	751	9	dementia	dementia	NN
cord-015684-q10sx1dm	751	10	:	:	:
cord-015684-q10sx1dm	751	11	implications	implication	NNS
cord-015684-q10sx1dm	751	12	for	for	IN
cord-015684-q10sx1dm	751	13	pharmacological	pharmacological	JJ
cord-015684-q10sx1dm	751	14	treatment	treatment	NN
cord-015684-q10sx1dm	752	1	A	a	DT
cord-015684-q10sx1dm	752	2	functional	functional	JJ
cord-015684-q10sx1dm	752	3	genomics	genomic	NNS
cord-015684-q10sx1dm	752	4	approach	approach	NN
cord-015684-q10sx1dm	752	5	to	to	IN
cord-015684-q10sx1dm	752	6	the	the	DT
cord-015684-q10sx1dm	752	7	analysis	analysis	NN
cord-015684-q10sx1dm	752	8	of	of	IN
cord-015684-q10sx1dm	752	9	biological	biological	JJ
cord-015684-q10sx1dm	752	10	markers	marker	NNS
cord-015684-q10sx1dm	752	11	in	in	IN
cord-015684-q10sx1dm	752	12	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	752	13	disease	disease	NN
cord-015684-q10sx1dm	752	14	Genomic	genomic	JJ
cord-015684-q10sx1dm	752	15	characterization	characterization	NN
cord-015684-q10sx1dm	752	16	of	of	IN
cord-015684-q10sx1dm	752	17	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	752	18	's	's	POS
cord-015684-q10sx1dm	752	19	disease	disease	NN
cord-015684-q10sx1dm	752	20	and	and	CC
cord-015684-q10sx1dm	752	21	genotype	genotype	NN
cord-015684-q10sx1dm	752	22	-	-	HYPH
cord-015684-q10sx1dm	752	23	related	relate	VBN
cord-015684-q10sx1dm	752	24	phenotypic	phenotypic	JJ
cord-015684-q10sx1dm	752	25	analysis	analysis	NN
cord-015684-q10sx1dm	752	26	of	of	IN
cord-015684-q10sx1dm	752	27	biological	biological	JJ
cord-015684-q10sx1dm	752	28	markers	marker	NNS
cord-015684-q10sx1dm	752	29	in	in	IN
cord-015684-q10sx1dm	752	30	dementia	dementia	NN
cord-015684-q10sx1dm	753	1	The	the	DT
cord-015684-q10sx1dm	753	2	histamine	histamine	NN
cord-015684-q10sx1dm	753	3	-	-	HYPH
cord-015684-q10sx1dm	753	4	cytokine	cytokine	NN
cord-015684-q10sx1dm	753	5	network	network	NN
cord-015684-q10sx1dm	753	6	in	in	IN
cord-015684-q10sx1dm	753	7	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	753	8	disease	disease	NN
cord-015684-q10sx1dm	753	9	:	:	:
cord-015684-q10sx1dm	753	10	etiopathogenic	etiopathogenic	NNP
cord-015684-q10sx1dm	753	11	and	and	CC
cord-015684-q10sx1dm	753	12	pharmacogenomic	pharmacogenomic	JJ
cord-015684-q10sx1dm	753	13	implications	implication	NNS
cord-015684-q10sx1dm	754	1	Histamine	histamine	NN
cord-015684-q10sx1dm	754	2	function	function	NN
cord-015684-q10sx1dm	754	3	in	in	IN
cord-015684-q10sx1dm	754	4	brain	brain	NN
cord-015684-q10sx1dm	754	5	disorders	disorder	NNS
cord-015684-q10sx1dm	754	6	Histamine	histamine	NN
cord-015684-q10sx1dm	754	7	in	in	IN
cord-015684-q10sx1dm	754	8	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	754	9	's	's	POS
cord-015684-q10sx1dm	754	10	disease	disease	NN
cord-015684-q10sx1dm	754	11	pathogenesis	pathogenesis	NN
cord-015684-q10sx1dm	754	12	:	:	:
cord-015684-q10sx1dm	754	13	biochemistry	biochemistry	NN
cord-015684-q10sx1dm	754	14	and	and	CC
cord-015684-q10sx1dm	754	15	functional	functional	JJ
cord-015684-q10sx1dm	754	16	genomics	genomic	NNS
cord-015684-q10sx1dm	754	17	Characterization	characterization	NN
cord-015684-q10sx1dm	754	18	of	of	IN
cord-015684-q10sx1dm	754	19	cytokine	cytokine	NN
cord-015684-q10sx1dm	754	20	production	production	NN
cord-015684-q10sx1dm	754	21	,	,	,
cord-015684-q10sx1dm	754	22	screening	screening	NN
cord-015684-q10sx1dm	754	23	of	of	IN
cord-015684-q10sx1dm	754	24	lymphocyte	lymphocyte	NN
cord-015684-q10sx1dm	754	25	subset	subset	VBN
cord-015684-q10sx1dm	754	26	patterns	pattern	NNS
cord-015684-q10sx1dm	754	27	and	and	CC
cord-015684-q10sx1dm	754	28	in	in	IN
cord-015684-q10sx1dm	754	29	vitro	vitro	FW
cord-015684-q10sx1dm	754	30	apoptosis	apoptosis	NN
cord-015684-q10sx1dm	754	31	in	in	IN
cord-015684-q10sx1dm	754	32	healthy	healthy	JJ
cord-015684-q10sx1dm	754	33	and	and	CC
cord-015684-q10sx1dm	754	34	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	754	35	's	's	POS
cord-015684-q10sx1dm	754	36	disease	disease	NN
cord-015684-q10sx1dm	754	37	individuals	individual	NNS
cord-015684-q10sx1dm	754	38	International	International	NNP
cord-015684-q10sx1dm	754	39	Human	Human	NNP
cord-015684-q10sx1dm	754	40	Genome	Genome	NNP
cord-015684-q10sx1dm	754	41	Sequencing	Sequencing	NNP
cord-015684-q10sx1dm	754	42	Consortium	Consortium	NNP
cord-015684-q10sx1dm	754	43	.	.	.
cord-015684-q10sx1dm	755	1	Finishing	finish	VBG
cord-015684-q10sx1dm	755	2	the	the	DT
cord-015684-q10sx1dm	755	3	euchromatic	euchromatic	JJ
cord-015684-q10sx1dm	755	4	sequence	sequence	NN
cord-015684-q10sx1dm	755	5	of	of	IN
cord-015684-q10sx1dm	755	6	the	the	DT
cord-015684-q10sx1dm	755	7	human	human	JJ
cord-015684-q10sx1dm	755	8	genome	genome	NN
cord-015684-q10sx1dm	755	9	Implications	implication	NNS
cord-015684-q10sx1dm	755	10	of	of	IN
cord-015684-q10sx1dm	755	11	the	the	DT
cord-015684-q10sx1dm	755	12	human	human	JJ
cord-015684-q10sx1dm	755	13	genome	genome	NN
cord-015684-q10sx1dm	755	14	for	for	IN
cord-015684-q10sx1dm	755	15	understanding	understand	VBG
cord-015684-q10sx1dm	755	16	human	human	JJ
cord-015684-q10sx1dm	755	17	biology	biology	NN
cord-015684-q10sx1dm	755	18	and	and	CC
cord-015684-q10sx1dm	755	19	medicine	medicine	NN
cord-015684-q10sx1dm	755	20	Pharmacogenetics	Pharmacogenetics	NNP
cord-015684-q10sx1dm	755	21	and	and	CC
cord-015684-q10sx1dm	755	22	pharmacogenomics	pharmacogenomic	NNS
cord-015684-q10sx1dm	755	23	.	.	.
cord-015684-q10sx1dm	756	1	In	in	IN
cord-015684-q10sx1dm	756	2	:	:	:
cord-015684-q10sx1dm	756	3	Emery	Emery	NNP
cord-015684-q10sx1dm	756	4	and	and	CC
cord-015684-q10sx1dm	756	5	Rimoin	Rimoin	NNP
cord-015684-q10sx1dm	756	6	's	's	POS
cord-015684-q10sx1dm	756	7	Principles	Principles	NNPS
cord-015684-q10sx1dm	756	8	and	and	CC
cord-015684-q10sx1dm	756	9	Practice	Practice	NNP
cord-015684-q10sx1dm	756	10	of	of	IN
cord-015684-q10sx1dm	756	11	Medical	Medical	NNP
cord-015684-q10sx1dm	756	12	Genetics	Genetics	NNP
cord-015684-q10sx1dm	756	13	.	.	.
cord-015684-q10sx1dm	757	1	4th	4th	JJ
cord-015684-q10sx1dm	757	2	Edn	Edn	NNP
cord-015684-q10sx1dm	757	3	Pharmacogenomics	Pharmacogenomics	NNPS
cord-015684-q10sx1dm	757	4	:	:	:
cord-015684-q10sx1dm	757	5	the	the	DT
cord-015684-q10sx1dm	757	6	inherited	inherit	VBN
cord-015684-q10sx1dm	757	7	basis	basis	NN
cord-015684-q10sx1dm	757	8	for	for	IN
cord-015684-q10sx1dm	757	9	interindividual	interindividual	JJ
cord-015684-q10sx1dm	757	10	differences	difference	NNS
cord-015684-q10sx1dm	757	11	in	in	IN
cord-015684-q10sx1dm	757	12	drug	drug	NN
cord-015684-q10sx1dm	757	13	response	response	NN
cord-015684-q10sx1dm	757	14	Pharmacogenetics	Pharmacogenetics	NNP
cord-015684-q10sx1dm	757	15	and	and	CC
cord-015684-q10sx1dm	757	16	pharmacogenomics	pharmacogenomic	NNS
cord-015684-q10sx1dm	757	17	:	:	:
cord-015684-q10sx1dm	757	18	development	development	NN
cord-015684-q10sx1dm	757	19	,	,	,
cord-015684-q10sx1dm	757	20	science	science	NN
cord-015684-q10sx1dm	757	21	,	,	,
cord-015684-q10sx1dm	757	22	and	and	CC
cord-015684-q10sx1dm	757	23	translation	translation	NN
cord-015684-q10sx1dm	757	24	Pharmacogenomics	Pharmacogenomics	NNPS
cord-015684-q10sx1dm	757	25	and	and	CC
cord-015684-q10sx1dm	757	26	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	757	27	prospect	prospect	NN
cord-015684-q10sx1dm	757	28	in	in	IN
cord-015684-q10sx1dm	757	29	dementia	dementia	NN
cord-015684-q10sx1dm	758	1	Pharmacogenetic	pharmacogenetic	JJ
cord-015684-q10sx1dm	758	2	basis	basis	NN
cord-015684-q10sx1dm	758	3	for	for	IN
cord-015684-q10sx1dm	758	4	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	758	5	optimization	optimization	NN
cord-015684-q10sx1dm	758	6	in	in	IN
cord-015684-q10sx1dm	758	7	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	758	8	's	's	POS
cord-015684-q10sx1dm	758	9	disease	disease	NN
cord-015684-q10sx1dm	758	10	Infl	Infl	NNP
cord-015684-q10sx1dm	758	11	uence	uence	NN
cord-015684-q10sx1dm	758	12	of	of	IN
cord-015684-q10sx1dm	758	13	pharmacogenetic	pharmacogenetic	JJ
cord-015684-q10sx1dm	758	14	factors	factor	NNS
cord-015684-q10sx1dm	758	15	on	on	IN
cord-015684-q10sx1dm	758	16	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	758	17	's	's	POS
cord-015684-q10sx1dm	758	18	disease	disease	NN
cord-015684-q10sx1dm	758	19	therapeutics	therapeutic	NNS
cord-015684-q10sx1dm	758	20	Pharmacogenetic	pharmacogenetic	JJ
cord-015684-q10sx1dm	758	21	aspects	aspect	NNS
cord-015684-q10sx1dm	758	22	of	of	IN
cord-015684-q10sx1dm	758	23	therapy	therapy	NN
cord-015684-q10sx1dm	758	24	with	with	IN
cord-015684-q10sx1dm	758	25	cholinesterase	cholinesterase	NN
cord-015684-q10sx1dm	758	26	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	758	27	:	:	:
cord-015684-q10sx1dm	758	28	the	the	DT
cord-015684-q10sx1dm	758	29	role	role	NN
cord-015684-q10sx1dm	758	30	of	of	IN
cord-015684-q10sx1dm	758	31	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	758	32	in	in	IN
cord-015684-q10sx1dm	758	33	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	758	34	's	's	POS
cord-015684-q10sx1dm	758	35	disease	disease	NN
cord-015684-q10sx1dm	758	36	pharmacogenetics	pharmacogenetic	NNS
cord-015684-q10sx1dm	758	37	From	from	IN
cord-015684-q10sx1dm	758	38	pharmacogenetics	pharmacogenetic	NNS
cord-015684-q10sx1dm	758	39	and	and	CC
cord-015684-q10sx1dm	758	40	ecogenetics	ecogenetic	NNS
cord-015684-q10sx1dm	758	41	to	to	IN
cord-015684-q10sx1dm	758	42	pharmacogenomics	pharmacogenomics	NNP
cord-015684-q10sx1dm	758	43	Inheritance	Inheritance	NNP
cord-015684-q10sx1dm	758	44	and	and	CC
cord-015684-q10sx1dm	758	45	drug	drug	NN
cord-015684-q10sx1dm	758	46	response	response	NN
cord-015684-q10sx1dm	758	47	Pharmacogenomics	Pharmacogenomics	NNP
cord-015684-q10sx1dm	758	48	-	-	HYPH
cord-015684-q10sx1dm	758	49	Drug	Drug	NNP
cord-015684-q10sx1dm	758	50	disposition	disposition	NN
cord-015684-q10sx1dm	758	51	,	,	,
cord-015684-q10sx1dm	758	52	drug	drug	NN
cord-015684-q10sx1dm	758	53	targets	target	NNS
cord-015684-q10sx1dm	758	54	,	,	,
cord-015684-q10sx1dm	758	55	and	and	CC
cord-015684-q10sx1dm	758	56	side	side	NN
cord-015684-q10sx1dm	758	57	effects	effect	NNS
cord-015684-q10sx1dm	759	1	National	national	JJ
cord-015684-q10sx1dm	759	2	estimates	estimate	NNS
cord-015684-q10sx1dm	759	3	of	of	IN
cord-015684-q10sx1dm	759	4	medication	medication	NN
cord-015684-q10sx1dm	759	5	use	use	NN
cord-015684-q10sx1dm	759	6	in	in	IN
cord-015684-q10sx1dm	759	7	nursing	nursing	NN
cord-015684-q10sx1dm	759	8	homes	home	NNS
cord-015684-q10sx1dm	760	1	Medicare	Medicare	NNP
cord-015684-q10sx1dm	760	2	Current	current	JJ
cord-015684-q10sx1dm	760	3	Benefi	Benefi	NNP
cord-015684-q10sx1dm	760	4	ciary	ciary	NN
cord-015684-q10sx1dm	760	5	Survey	Survey	NNP
cord-015684-q10sx1dm	760	6	and	and	CC
cord-015684-q10sx1dm	760	7	the	the	DT
cord-015684-q10sx1dm	760	8	1996	1996	CD
cord-015684-q10sx1dm	760	9	Medical	Medical	NNP
cord-015684-q10sx1dm	760	10	Expenditure	Expenditure	NNP
cord-015684-q10sx1dm	760	11	Survey	Survey	NNP
cord-015684-q10sx1dm	760	12	Antidepressant	Antidepressant	NNP
cord-015684-q10sx1dm	760	13	drugs	drug	NNS
cord-015684-q10sx1dm	760	14	prescribing	prescribe	VBG
cord-015684-q10sx1dm	760	15	among	among	IN
cord-015684-q10sx1dm	760	16	elderly	elderly	JJ
cord-015684-q10sx1dm	760	17	subjects	subject	NNS
cord-015684-q10sx1dm	760	18	:	:	:
cord-015684-q10sx1dm	760	19	a	a	DT
cord-015684-q10sx1dm	760	20	population	population	NN
cord-015684-q10sx1dm	760	21	-	-	HYPH
cord-015684-q10sx1dm	760	22	based	base	VBN
cord-015684-q10sx1dm	760	23	study	study	NN
cord-015684-q10sx1dm	760	24	Potentially	potentially	RB
cord-015684-q10sx1dm	760	25	inappropriate	inappropriate	JJ
cord-015684-q10sx1dm	760	26	medication	medication	NN
cord-015684-q10sx1dm	760	27	use	use	NN
cord-015684-q10sx1dm	760	28	among	among	IN
cord-015684-q10sx1dm	760	29	elderly	elderly	JJ
cord-015684-q10sx1dm	760	30	home	home	NN
cord-015684-q10sx1dm	760	31	care	care	NN
cord-015684-q10sx1dm	760	32	patients	patient	NNS
cord-015684-q10sx1dm	760	33	in	in	IN
cord-015684-q10sx1dm	760	34	Europe	Europe	NNP
cord-015684-q10sx1dm	760	35	Potentially	Potentially	NNP
cord-015684-q10sx1dm	760	36	inappropriate	inappropriate	JJ
cord-015684-q10sx1dm	760	37	medication	medication	NN
cord-015684-q10sx1dm	760	38	use	use	NN
cord-015684-q10sx1dm	760	39	by	by	IN
cord-015684-q10sx1dm	760	40	elderly	elderly	JJ
cord-015684-q10sx1dm	760	41	persons	person	NNS
cord-015684-q10sx1dm	760	42	in	in	IN
cord-015684-q10sx1dm	760	43	U.S.	U.S.	NNP
cord-015684-q10sx1dm	760	44	Health	Health	NNP
cord-015684-q10sx1dm	760	45	Maintenance	Maintenance	NNP
cord-015684-q10sx1dm	760	46	Organizations	Organizations	NNPS
cord-015684-q10sx1dm	761	1	The	the	DT
cord-015684-q10sx1dm	761	2	Metabolic	Metabolic	NNP
cord-015684-q10sx1dm	761	3	&	&	CC
cord-015684-q10sx1dm	761	4	Molecular	molecular	JJ
cord-015684-q10sx1dm	761	5	Bases	Bases	NNPS
cord-015684-q10sx1dm	761	6	of	of	IN
cord-015684-q10sx1dm	761	7	Inherited	Inherited	NNP
cord-015684-q10sx1dm	761	8	Disease	Disease	NNP
cord-015684-q10sx1dm	761	9	Catalog	Catalog	NNP
cord-015684-q10sx1dm	761	10	of	of	IN
cord-015684-q10sx1dm	761	11	680	680	CD
cord-015684-q10sx1dm	761	12	variants	variant	NNS
cord-015684-q10sx1dm	761	13	among	among	IN
cord-015684-q10sx1dm	761	14	eight	eight	CD
cord-015684-q10sx1dm	761	15	cytochrome	cytochrome	NN
cord-015684-q10sx1dm	761	16	P450	p450	NN
cord-015684-q10sx1dm	761	17	(	(	-LRB-
cord-015684-q10sx1dm	761	18	CYP	CYP	NNP
cord-015684-q10sx1dm	761	19	)	)	-RRB-
cord-015684-q10sx1dm	761	20	genes	gene	NNS
cord-015684-q10sx1dm	761	21	:	:	:
cord-015684-q10sx1dm	761	22	nine	nine	CD
cord-015684-q10sx1dm	761	23	esterase	esterase	NN
cord-015684-q10sx1dm	761	24	genes	gene	NNS
cord-015684-q10sx1dm	761	25	,	,	,
cord-015684-q10sx1dm	761	26	and	and	CC
cord-015684-q10sx1dm	761	27	two	two	CD
cord-015684-q10sx1dm	761	28	other	other	JJ
cord-015684-q10sx1dm	761	29	genes	gene	NNS
cord-015684-q10sx1dm	761	30	in	in	IN
cord-015684-q10sx1dm	761	31	the	the	DT
cord-015684-q10sx1dm	761	32	Japanese	japanese	JJ
cord-015684-q10sx1dm	761	33	population	population	NN
cord-015684-q10sx1dm	761	34	DNA	dna	NN
cord-015684-q10sx1dm	761	35	sequence	sequence	NN
cord-015684-q10sx1dm	761	36	variations	variation	NNS
cord-015684-q10sx1dm	761	37	in	in	IN
cord-015684-q10sx1dm	761	38	a	a	DT
cord-015684-q10sx1dm	761	39	3.7-kb	3.7-kb	CD
cord-015684-q10sx1dm	761	40	noncoding	noncoding	JJ
cord-015684-q10sx1dm	761	41	sequence	sequence	NN
cord-015684-q10sx1dm	761	42	5-prime	5-prime	CD
cord-015684-q10sx1dm	761	43	of	of	IN
cord-015684-q10sx1dm	761	44	the	the	DT
cord-015684-q10sx1dm	761	45	CYP1A2	CYP1A2	NNP
cord-015684-q10sx1dm	761	46	gene	gene	NN
cord-015684-q10sx1dm	761	47	:	:	:
cord-015684-q10sx1dm	761	48	implications	implication	NNS
cord-015684-q10sx1dm	761	49	for	for	IN
cord-015684-q10sx1dm	761	50	human	human	JJ
cord-015684-q10sx1dm	761	51	population	population	NN
cord-015684-q10sx1dm	761	52	history	history	NN
cord-015684-q10sx1dm	761	53	and	and	CC
cord-015684-q10sx1dm	761	54	natural	natural	JJ
cord-015684-q10sx1dm	761	55	selection	selection	NN
cord-015684-q10sx1dm	761	56	PM	pm	NN
cord-015684-q10sx1dm	761	57	frequencies	frequency	NNS
cord-015684-q10sx1dm	761	58	of	of	IN
cord-015684-q10sx1dm	761	59	major	major	JJ
cord-015684-q10sx1dm	761	60	CYPs	cyps	NN
cord-015684-q10sx1dm	761	61	in	in	IN
cord-015684-q10sx1dm	761	62	Asians	Asians	NNPS
cord-015684-q10sx1dm	761	63	and	and	CC
cord-015684-q10sx1dm	761	64	Caucasians	Caucasians	NNPS
cord-015684-q10sx1dm	761	65	Polymorphisms	polymorphism	NNS
cord-015684-q10sx1dm	761	66	of	of	IN
cord-015684-q10sx1dm	761	67	drug	drug	NN
cord-015684-q10sx1dm	761	68	-	-	HYPH
cord-015684-q10sx1dm	761	69	metabolizing	metabolize	VBG
cord-015684-q10sx1dm	761	70	enzymes	enzyme	NNS
cord-015684-q10sx1dm	761	71	CYP2C9	CYP2C9	NNP
cord-015684-q10sx1dm	761	72	,	,	,
cord-015684-q10sx1dm	761	73	CYP2C19	CYP2C19	NNP
cord-015684-q10sx1dm	761	74	,	,	,
cord-015684-q10sx1dm	761	75	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	761	76	,	,	,
cord-015684-q10sx1dm	761	77	CYP1A1	CYP1A1	NNP
cord-015684-q10sx1dm	761	78	,	,	,
cord-015684-q10sx1dm	761	79	NAT2	NAT2	NNP
cord-015684-q10sx1dm	761	80	and	and	CC
cord-015684-q10sx1dm	761	81	of	of	IN
cord-015684-q10sx1dm	761	82	P	p	NN
cord-015684-q10sx1dm	761	83	-	-	HYPH
cord-015684-q10sx1dm	761	84	glycoprotein	glycoprotein	NN
cord-015684-q10sx1dm	761	85	in	in	IN
cord-015684-q10sx1dm	761	86	a	a	DT
cord-015684-q10sx1dm	761	87	Russian	russian	JJ
cord-015684-q10sx1dm	761	88	population	population	NN
cord-015684-q10sx1dm	761	89	CYP2C9	cyp2c9	IN
cord-015684-q10sx1dm	761	90	allelic	allelic	JJ
cord-015684-q10sx1dm	761	91	variants	variant	NNS
cord-015684-q10sx1dm	761	92	:	:	:
cord-015684-q10sx1dm	761	93	ethnic	ethnic	JJ
cord-015684-q10sx1dm	761	94	distribution	distribution	NN
cord-015684-q10sx1dm	761	95	and	and	CC
cord-015684-q10sx1dm	761	96	functional	functional	JJ
cord-015684-q10sx1dm	761	97	signifi	signifi	NN
cord-015684-q10sx1dm	761	98	cance	cance	NN
cord-015684-q10sx1dm	761	99	Identifi	Identifi	NNP
cord-015684-q10sx1dm	761	100	cation	cation	NN
cord-015684-q10sx1dm	761	101	and	and	CC
cord-015684-q10sx1dm	761	102	functional	functional	JJ
cord-015684-q10sx1dm	761	103	characterization	characterization	NN
cord-015684-q10sx1dm	761	104	of	of	IN
cord-015684-q10sx1dm	761	105	a	a	DT
cord-015684-q10sx1dm	761	106	new	new	JJ
cord-015684-q10sx1dm	761	107	CYP2C9	CYP2C9	NNP
cord-015684-q10sx1dm	761	108	variant	variant	NN
cord-015684-q10sx1dm	761	109	(	(	-LRB-
cord-015684-q10sx1dm	761	110	CYP2C9	cyp2c9	NN
cord-015684-q10sx1dm	761	111	*	*	NFP
cord-015684-q10sx1dm	761	112	5	5	CD
cord-015684-q10sx1dm	761	113	1	1	CD
cord-015684-q10sx1dm	761	114	)	)	-RRB-
cord-015684-q10sx1dm	761	115	expressed	express	VBN
cord-015684-q10sx1dm	761	116	among	among	IN
cord-015684-q10sx1dm	761	117	African	African	NNP
cord-015684-q10sx1dm	761	118	Americans	Americans	NNPS
cord-015684-q10sx1dm	761	119	Molecular	molecular	JJ
cord-015684-q10sx1dm	761	120	basis	basis	NN
cord-015684-q10sx1dm	761	121	of	of	IN
cord-015684-q10sx1dm	761	122	ethnic	ethnic	JJ
cord-015684-q10sx1dm	761	123	differences	difference	NNS
cord-015684-q10sx1dm	761	124	in	in	IN
cord-015684-q10sx1dm	761	125	drug	drug	NN
cord-015684-q10sx1dm	761	126	disposition	disposition	NN
cord-015684-q10sx1dm	761	127	and	and	CC
cord-015684-q10sx1dm	761	128	response	response	NN
cord-015684-q10sx1dm	761	129	Isolation	isolation	NN
cord-015684-q10sx1dm	761	130	,	,	,
cord-015684-q10sx1dm	761	131	sequence	sequence	NN
cord-015684-q10sx1dm	761	132	and	and	CC
cord-015684-q10sx1dm	761	133	genotyping	genotyping	NN
cord-015684-q10sx1dm	761	134	of	of	IN
cord-015684-q10sx1dm	761	135	the	the	DT
cord-015684-q10sx1dm	761	136	drug	drug	NN
cord-015684-q10sx1dm	761	137	metabolizer	metabolizer	NN
cord-015684-q10sx1dm	761	138	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	761	139	gene	gene	NN
cord-015684-q10sx1dm	761	140	in	in	IN
cord-015684-q10sx1dm	761	141	the	the	DT
cord-015684-q10sx1dm	761	142	Colombian	colombian	JJ
cord-015684-q10sx1dm	761	143	population	population	NN
cord-015684-q10sx1dm	761	144	Effects	effect	NNS
cord-015684-q10sx1dm	761	145	of	of	IN
cord-015684-q10sx1dm	761	146	prototypical	prototypical	JJ
cord-015684-q10sx1dm	761	147	microsomal	microsomal	NN
cord-015684-q10sx1dm	761	148	enzyme	enzyme	NN
cord-015684-q10sx1dm	761	149	inducers	inducer	NNS
cord-015684-q10sx1dm	761	150	on	on	IN
cord-015684-q10sx1dm	761	151	cytochrome	cytochrome	NN
cord-015684-q10sx1dm	761	152	P450	p450	JJ
cord-015684-q10sx1dm	761	153	expression	expression	NN
cord-015684-q10sx1dm	761	154	in	in	IN
cord-015684-q10sx1dm	761	155	cultured	cultured	JJ
cord-015684-q10sx1dm	761	156	human	human	JJ
cord-015684-q10sx1dm	761	157	hepatocytes	hepatocyte	NNS
cord-015684-q10sx1dm	761	158	Cytochrome	cytochrome	NN
cord-015684-q10sx1dm	761	159	P450	P450	NNPS
cord-015684-q10sx1dm	761	160	in	in	IN
cord-015684-q10sx1dm	761	161	the	the	DT
cord-015684-q10sx1dm	761	162	brain	brain	NN
cord-015684-q10sx1dm	761	163	:	:	:
cord-015684-q10sx1dm	762	1	a	a	DT
cord-015684-q10sx1dm	762	2	review	review	NN
cord-015684-q10sx1dm	763	1	The	the	DT
cord-015684-q10sx1dm	763	2	expression	expression	NN
cord-015684-q10sx1dm	763	3	of	of	IN
cord-015684-q10sx1dm	763	4	CYP2B6	CYP2B6	NNP
cord-015684-q10sx1dm	763	5	,	,	,
cord-015684-q10sx1dm	763	6	CYP2C9	CYP2C9	NNP
cord-015684-q10sx1dm	763	7	and	and	CC
cord-015684-q10sx1dm	763	8	CYP2A4	CYP2A4	NNPS
cord-015684-q10sx1dm	763	9	genes	gene	NNS
cord-015684-q10sx1dm	763	10	:	:	:
cord-015684-q10sx1dm	763	11	a	a	DT
cord-015684-q10sx1dm	763	12	tangle	tangle	NN
cord-015684-q10sx1dm	763	13	of	of	IN
cord-015684-q10sx1dm	763	14	networks	network	NNS
cord-015684-q10sx1dm	763	15	of	of	IN
cord-015684-q10sx1dm	763	16	nuclear	nuclear	JJ
cord-015684-q10sx1dm	763	17	and	and	CC
cord-015684-q10sx1dm	763	18	steroid	steroid	JJ
cord-015684-q10sx1dm	763	19	receptors	receptor	NNS
cord-015684-q10sx1dm	763	20	Regulation	regulation	NN
cord-015684-q10sx1dm	763	21	of	of	IN
cord-015684-q10sx1dm	763	22	cytochrome	cytochrome	NN
cord-015684-q10sx1dm	763	23	P450	p450	NN
cord-015684-q10sx1dm	763	24	(	(	-LRB-
cord-015684-q10sx1dm	763	25	CYP	CYP	NNP
cord-015684-q10sx1dm	763	26	)	)	-RRB-
cord-015684-q10sx1dm	763	27	genes	gene	NNS
cord-015684-q10sx1dm	763	28	by	by	IN
cord-015684-q10sx1dm	763	29	nuclear	nuclear	JJ
cord-015684-q10sx1dm	763	30	receptors	receptor	NNS
cord-015684-q10sx1dm	764	1	The	the	DT
cord-015684-q10sx1dm	764	2	CYP2C19	CYP2C19	NNP
cord-015684-q10sx1dm	764	3	enzyme	enzyme	NN
cord-015684-q10sx1dm	764	4	polymorphism	polymorphism	NN
cord-015684-q10sx1dm	764	5	Cytochrome	cytochrome	NN
cord-015684-q10sx1dm	764	6	P450	p450	NN
cord-015684-q10sx1dm	764	7	2D6	2d6	CD
cord-015684-q10sx1dm	764	8	variants	variant	NNS
cord-015684-q10sx1dm	764	9	in	in	IN
cord-015684-q10sx1dm	764	10	a	a	DT
cord-015684-q10sx1dm	764	11	Caucasian	caucasian	JJ
cord-015684-q10sx1dm	764	12	population	population	NN
cord-015684-q10sx1dm	764	13	:	:	:
cord-015684-q10sx1dm	765	1	allele	allele	NN
cord-015684-q10sx1dm	765	2	frequencies	frequency	NNS
cord-015684-q10sx1dm	765	3	and	and	CC
cord-015684-q10sx1dm	765	4	phenotypic	phenotypic	JJ
cord-015684-q10sx1dm	765	5	consequences	consequence	NNS
cord-015684-q10sx1dm	766	1	Clinically	clinically	RB
cord-015684-q10sx1dm	766	2	signifi	signifi	NNP
cord-015684-q10sx1dm	766	3	ca	can	MD
cord-015684-q10sx1dm	766	4	nt	not	RB
cord-015684-q10sx1dm	766	5	drug	drug	NN
cord-015684-q10sx1dm	766	6	interactions	interaction	NNS
cord-015684-q10sx1dm	766	7	with	with	IN
cord-015684-q10sx1dm	766	8	cholinesterase	cholinesterase	NN
cord-015684-q10sx1dm	766	9	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	766	10	:	:	:
cord-015684-q10sx1dm	766	11	a	a	DT
cord-015684-q10sx1dm	766	12	guide	guide	NN
cord-015684-q10sx1dm	766	13	for	for	IN
cord-015684-q10sx1dm	766	14	neurologists	neurologist	NNS
cord-015684-q10sx1dm	766	15	Assessment	Assessment	NNP
cord-015684-q10sx1dm	766	16	of	of	IN
cord-015684-q10sx1dm	766	17	the	the	DT
cord-015684-q10sx1dm	766	18	predictive	predictive	JJ
cord-015684-q10sx1dm	766	19	power	power	NN
cord-015684-q10sx1dm	766	20	of	of	IN
cord-015684-q10sx1dm	766	21	genotypes	genotype	NNS
cord-015684-q10sx1dm	766	22	for	for	IN
cord-015684-q10sx1dm	766	23	the	the	DT
cord-015684-q10sx1dm	766	24	in	in	IN
cord-015684-q10sx1dm	766	25	-	-	HYPH
cord-015684-q10sx1dm	766	26	vivo	vivo	NN
cord-015684-q10sx1dm	766	27	catalytic	catalytic	JJ
cord-015684-q10sx1dm	766	28	function	function	NN
cord-015684-q10sx1dm	766	29	of	of	IN
cord-015684-q10sx1dm	766	30	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	766	31	in	in	IN
cord-015684-q10sx1dm	766	32	a	a	DT
cord-015684-q10sx1dm	766	33	German	german	JJ
cord-015684-q10sx1dm	766	34	population	population	NN
cord-015684-q10sx1dm	766	35	Ten	ten	CD
cord-015684-q10sx1dm	766	36	percent	percent	NN
cord-015684-q10sx1dm	766	37	of	of	IN
cord-015684-q10sx1dm	766	38	North	north	JJ
cord-015684-q10sx1dm	766	39	Spanish	spanish	JJ
cord-015684-q10sx1dm	766	40	individuals	individual	NNS
cord-015684-q10sx1dm	767	1	carry	carry	VB
cord-015684-q10sx1dm	767	2	duplicated	duplicate	VBN
cord-015684-q10sx1dm	767	3	or	or	CC
cord-015684-q10sx1dm	767	4	triplicated	triplicate	VBN
cord-015684-q10sx1dm	767	5	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	767	6	genes	gene	NNS
cord-015684-q10sx1dm	767	7	associated	associate	VBN
cord-015684-q10sx1dm	767	8	with	with	IN
cord-015684-q10sx1dm	767	9	ultrarapid	ultrarapid	JJ
cord-015684-q10sx1dm	767	10	metabolism	metabolism	NN
cord-015684-q10sx1dm	767	11	of	of	IN
cord-015684-q10sx1dm	767	12	debrisoquine	debrisoquine	NNP
cord-015684-q10sx1dm	767	13	Clinical	clinical	JJ
cord-015684-q10sx1dm	767	14	pharmacokinetics	pharmacokinetic	NNS
cord-015684-q10sx1dm	767	15	of	of	IN
cord-015684-q10sx1dm	767	16	galantamine	galantamine	NNP
cord-015684-q10sx1dm	767	17	Impact	Impact	NNP
cord-015684-q10sx1dm	767	18	of	of	IN
cord-015684-q10sx1dm	767	19	the	the	DT
cord-015684-q10sx1dm	767	20	CYP2D6	cyp2d6	JJ
cord-015684-q10sx1dm	767	21	polymorphism	polymorphism	NN
cord-015684-q10sx1dm	767	22	on	on	IN
cord-015684-q10sx1dm	767	23	steady	steady	JJ
cord-015684-q10sx1dm	767	24	-	-	HYPH
cord-015684-q10sx1dm	767	25	state	state	NN
cord-015684-q10sx1dm	767	26	plasma	plasma	NN
cord-015684-q10sx1dm	767	27	concentrations	concentration	NNS
cord-015684-q10sx1dm	767	28	and	and	CC
cord-015684-q10sx1dm	767	29	clinical	clinical	JJ
cord-015684-q10sx1dm	767	30	outcome	outcome	NN
cord-015684-q10sx1dm	767	31	of	of	IN
cord-015684-q10sx1dm	767	32	donepezil	donepezil	NNP
cord-015684-q10sx1dm	767	33	in	in	IN
cord-015684-q10sx1dm	767	34	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	767	35	's	's	POS
cord-015684-q10sx1dm	767	36	disease	disease	NN
cord-015684-q10sx1dm	767	37	patients	patient	NNS
cord-015684-q10sx1dm	767	38	Molecular	molecular	JJ
cord-015684-q10sx1dm	767	39	pathology	pathology	NN
cord-015684-q10sx1dm	767	40	and	and	CC
cord-015684-q10sx1dm	767	41	pharmacogenomics	pharmacogenomic	NNS
cord-015684-q10sx1dm	767	42	in	in	IN
cord-015684-q10sx1dm	767	43	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	767	44	's	's	POS
cord-015684-q10sx1dm	767	45	disease	disease	NN
cord-015684-q10sx1dm	767	46	:	:	:
cord-015684-q10sx1dm	767	47	polygenic	polygenic	RB
cord-015684-q10sx1dm	767	48	-	-	HYPH
cord-015684-q10sx1dm	767	49	related	relate	VBN
cord-015684-q10sx1dm	767	50	effects	effect	NNS
cord-015684-q10sx1dm	767	51	of	of	IN
cord-015684-q10sx1dm	767	52	multifactorial	multifactorial	JJ
cord-015684-q10sx1dm	767	53	treatments	treatment	NNS
cord-015684-q10sx1dm	767	54	on	on	IN
cord-015684-q10sx1dm	767	55	cognition	cognition	NN
cord-015684-q10sx1dm	767	56	,	,	,
cord-015684-q10sx1dm	767	57	anxiety	anxiety	NN
cord-015684-q10sx1dm	767	58	,	,	,
cord-015684-q10sx1dm	767	59	and	and	CC
cord-015684-q10sx1dm	767	60	depression	depression	NN
cord-015684-q10sx1dm	767	61	Pharmacogenomic	Pharmacogenomic	NNP
cord-015684-q10sx1dm	767	62	studies	study	NNS
cord-015684-q10sx1dm	767	63	with	with	IN
cord-015684-q10sx1dm	767	64	a	a	DT
cord-015684-q10sx1dm	767	65	combination	combination	NN
cord-015684-q10sx1dm	767	66	therapy	therapy	NN
cord-015684-q10sx1dm	767	67	in	in	IN
cord-015684-q10sx1dm	767	68	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	767	69	's	's	POS
cord-015684-q10sx1dm	767	70	disease	disease	NN
cord-015684-q10sx1dm	767	71	Interethnic	Interethnic	NNP
cord-015684-q10sx1dm	767	72	differences	difference	NNS
cord-015684-q10sx1dm	767	73	in	in	IN
cord-015684-q10sx1dm	767	74	genetic	genetic	JJ
cord-015684-q10sx1dm	767	75	polymorphisms	polymorphism	NNS
cord-015684-q10sx1dm	767	76	of	of	IN
cord-015684-q10sx1dm	767	77	CYP2D6	CYP2D6	NNPS
cord-015684-q10sx1dm	767	78	in	in	IN
cord-015684-q10sx1dm	767	79	the	the	DT
cord-015684-q10sx1dm	767	80	U.S.	U.S.	NNP
cord-015684-q10sx1dm	767	81	population	population	NN
cord-015684-q10sx1dm	767	82	:	:	:
cord-015684-q10sx1dm	767	83	clinical	clinical	JJ
cord-015684-q10sx1dm	767	84	implications	implication	NNS
cord-015684-q10sx1dm	767	85	Donepezil	Donepezil	NNP
cord-015684-q10sx1dm	767	86	use	use	NN
cord-015684-q10sx1dm	767	87	in	in	IN
cord-015684-q10sx1dm	767	88	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	767	89	disease	disease	NN
cord-015684-q10sx1dm	767	90	Effects	effect	NNS
cord-015684-q10sx1dm	767	91	of	of	IN
cord-015684-q10sx1dm	767	92	cholinergic	cholinergic	JJ
cord-015684-q10sx1dm	767	93	markers	marker	NNS
cord-015684-q10sx1dm	767	94	in	in	IN
cord-015684-q10sx1dm	767	95	rat	rat	NN
cord-015684-q10sx1dm	767	96	brain	brain	NN
cord-015684-q10sx1dm	767	97	and	and	CC
cord-015684-q10sx1dm	767	98	blood	blood	NN
cord-015684-q10sx1dm	767	99	after	after	IN
cord-015684-q10sx1dm	767	100	short	short	JJ
cord-015684-q10sx1dm	767	101	and	and	CC
cord-015684-q10sx1dm	767	102	prolonged	prolonged	JJ
cord-015684-q10sx1dm	767	103	administration	administration	NN
cord-015684-q10sx1dm	767	104	of	of	IN
cord-015684-q10sx1dm	767	105	donepezil	donepezil	NNP
cord-015684-q10sx1dm	768	1	The	the	DT
cord-015684-q10sx1dm	768	2	O	o	NN
cord-015684-q10sx1dm	768	3	-	-	HYPH
cord-015684-q10sx1dm	768	4	demethylation	demethylation	NN
cord-015684-q10sx1dm	768	5	of	of	IN
cord-015684-q10sx1dm	768	6	the	the	DT
cord-015684-q10sx1dm	768	7	antidementia	antidementia	NNP
cord-015684-q10sx1dm	768	8	drug	drug	NNP
cord-015684-q10sx1dm	768	9	galantamine	galantamine	NNP
cord-015684-q10sx1dm	768	10	is	be	VBZ
cord-015684-q10sx1dm	768	11	catalyzed	catalyze	VBN
cord-015684-q10sx1dm	768	12	by	by	IN
cord-015684-q10sx1dm	768	13	cytochrome	cytochrome	NN
cord-015684-q10sx1dm	768	14	P450	p450	NN
cord-015684-q10sx1dm	768	15	2D6	2d6	CD
cord-015684-q10sx1dm	768	16	Cholinesterase	Cholinesterase	NNP
cord-015684-q10sx1dm	768	17	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	768	18	in	in	IN
cord-015684-q10sx1dm	768	19	the	the	DT
cord-015684-q10sx1dm	768	20	treatment	treatment	NN
cord-015684-q10sx1dm	768	21	of	of	IN
cord-015684-q10sx1dm	768	22	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	768	23	's	's	POS
cord-015684-q10sx1dm	768	24	disease	disease	NN
cord-015684-q10sx1dm	768	25	:	:	:
cord-015684-q10sx1dm	768	26	a	a	DT
cord-015684-q10sx1dm	768	27	comparison	comparison	NN
cord-015684-q10sx1dm	768	28	of	of	IN
cord-015684-q10sx1dm	768	29	tolerability	tolerability	NN
cord-015684-q10sx1dm	768	30	and	and	CC
cord-015684-q10sx1dm	768	31	pharmacology	pharmacology	NN
cord-015684-q10sx1dm	768	32	Galantamine	Galantamine	NNP
cord-015684-q10sx1dm	768	33	pharmacokinetics	pharmacokinetic	NNS
cord-015684-q10sx1dm	768	34	,	,	,
cord-015684-q10sx1dm	768	35	safety	safety	NN
cord-015684-q10sx1dm	768	36	,	,	,
cord-015684-q10sx1dm	768	37	and	and	CC
cord-015684-q10sx1dm	768	38	tolerability	tolerability	NN
cord-015684-q10sx1dm	768	39	profi	profi	NNP
cord-015684-q10sx1dm	768	40	les	les	NNP
cord-015684-q10sx1dm	768	41	are	be	VBP
cord-015684-q10sx1dm	768	42	similar	similar	JJ
cord-015684-q10sx1dm	768	43	in	in	IN
cord-015684-q10sx1dm	768	44	healthy	healthy	JJ
cord-015684-q10sx1dm	768	45	Caucasian	caucasian	JJ
cord-015684-q10sx1dm	768	46	and	and	CC
cord-015684-q10sx1dm	768	47	Japanese	japanese	JJ
cord-015684-q10sx1dm	768	48	subjects	subject	NNS
cord-015684-q10sx1dm	768	49	Pharmacokinetics	pharmacokinetic	NNS
cord-015684-q10sx1dm	768	50	and	and	CC
cord-015684-q10sx1dm	768	51	drug	drug	NN
cord-015684-q10sx1dm	768	52	interactions	interaction	NNS
cord-015684-q10sx1dm	768	53	of	of	IN
cord-015684-q10sx1dm	768	54	cholinesterase	cholinesterase	NN
cord-015684-q10sx1dm	768	55	inhibitors	inhibitor	NNS
cord-015684-q10sx1dm	768	56	administered	administer	VBN
cord-015684-q10sx1dm	768	57	in	in	IN
cord-015684-q10sx1dm	768	58	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	768	59	's	's	POS
cord-015684-q10sx1dm	768	60	disease	disease	NN
cord-015684-q10sx1dm	769	1	The	the	DT
cord-015684-q10sx1dm	769	2	metabolism	metabolism	NN
cord-015684-q10sx1dm	769	3	and	and	CC
cord-015684-q10sx1dm	769	4	excretion	excretion	NN
cord-015684-q10sx1dm	769	5	of	of	IN
cord-015684-q10sx1dm	769	6	galantamine	galantamine	NN
cord-015684-q10sx1dm	769	7	in	in	IN
cord-015684-q10sx1dm	769	8	rats	rat	NNS
cord-015684-q10sx1dm	769	9	,	,	,
cord-015684-q10sx1dm	769	10	dogs	dog	NNS
cord-015684-q10sx1dm	769	11	,	,	,
cord-015684-q10sx1dm	769	12	and	and	CC
cord-015684-q10sx1dm	769	13	humans	human	NNS
cord-015684-q10sx1dm	769	14	Prevalence	prevalence	NN
cord-015684-q10sx1dm	769	15	of	of	IN
cord-015684-q10sx1dm	769	16	potentially	potentially	RB
cord-015684-q10sx1dm	769	17	inappropriate	inappropriate	JJ
cord-015684-q10sx1dm	769	18	medication	medication	NN
cord-015684-q10sx1dm	769	19	use	use	NN
cord-015684-q10sx1dm	769	20	in	in	IN
cord-015684-q10sx1dm	769	21	elderly	elderly	JJ
cord-015684-q10sx1dm	769	22	patients	patient	NNS
cord-015684-q10sx1dm	769	23	.	.	.
cord-015684-q10sx1dm	770	1	Comparison	comparison	NN
cord-015684-q10sx1dm	770	2	between	between	IN
cord-015684-q10sx1dm	770	3	general	general	JJ
cord-015684-q10sx1dm	770	4	medicine	medicine	NN
cord-015684-q10sx1dm	770	5	and	and	CC
cord-015684-q10sx1dm	770	6	geriatric	geriatric	JJ
cord-015684-q10sx1dm	770	7	wards	ward	NNS
cord-015684-q10sx1dm	770	8	PharGKB	PharGKB	NNP
cord-015684-q10sx1dm	770	9	update	update	NN
cord-015684-q10sx1dm	770	10	:	:	:
cord-015684-q10sx1dm	770	11	II	II	NNP
cord-015684-q10sx1dm	770	12	.	.	.
cord-015684-q10sx1dm	771	1	CYP3A5	cyp3a5	JJ
cord-015684-q10sx1dm	771	2	,	,	,
cord-015684-q10sx1dm	771	3	cytochrome	cytochrome	NN
cord-015684-q10sx1dm	771	4	P450	p450	NN
cord-015684-q10sx1dm	771	5	,	,	,
cord-015684-q10sx1dm	771	6	family	family	NN
cord-015684-q10sx1dm	771	7	3	3	CD
cord-015684-q10sx1dm	771	8	,	,	,
cord-015684-q10sx1dm	771	9	subfamily	subfamily	RB
cord-015684-q10sx1dm	771	10	A	a	DT
cord-015684-q10sx1dm	771	11	,	,	,
cord-015684-q10sx1dm	771	12	polypeptide	polypeptide	NN
cord-015684-q10sx1dm	771	13	5	5	CD
cord-015684-q10sx1dm	771	14	Genomics	genomic	NNS
cord-015684-q10sx1dm	771	15	and	and	CC
cord-015684-q10sx1dm	771	16	the	the	DT
cord-015684-q10sx1dm	771	17	future	future	NN
cord-015684-q10sx1dm	771	18	of	of	IN
cord-015684-q10sx1dm	771	19	pharmacotherapy	pharmacotherapy	NN
cord-015684-q10sx1dm	771	20	in	in	IN
cord-015684-q10sx1dm	771	21	psychiatry	psychiatry	NN
cord-015684-q10sx1dm	771	22	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	771	23	polymorphism	polymorphism	NN
cord-015684-q10sx1dm	771	24	:	:	:
cord-015684-q10sx1dm	771	25	implications	implication	NNS
cord-015684-q10sx1dm	771	26	for	for	IN
cord-015684-q10sx1dm	771	27	antipsychotic	antipsychotic	JJ
cord-015684-q10sx1dm	771	28	drug	drug	NN
cord-015684-q10sx1dm	771	29	response	response	NN
cord-015684-q10sx1dm	771	30	,	,	,
cord-015684-q10sx1dm	771	31	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	771	32	and	and	CC
cord-015684-q10sx1dm	771	33	personality	personality	NN
cord-015684-q10sx1dm	771	34	traits	trait	NNS
cord-015684-q10sx1dm	771	35	Cytochrome	cytochrome	IN
cord-015684-q10sx1dm	771	36	P450	p450	JJ
cord-015684-q10sx1dm	771	37	polymorphisms	polymorphism	NNS
cord-015684-q10sx1dm	771	38	and	and	CC
cord-015684-q10sx1dm	771	39	response	response	NN
cord-015684-q10sx1dm	771	40	to	to	IN
cord-015684-q10sx1dm	771	41	antipsychotic	antipsychotic	JJ
cord-015684-q10sx1dm	771	42	therapy	therapy	NN
cord-015684-q10sx1dm	771	43	Infl	Infl	NNP
cord-015684-q10sx1dm	771	44	uence	uence	NN
cord-015684-q10sx1dm	771	45	of	of	IN
cord-015684-q10sx1dm	771	46	cytochrome	cytochrome	NN
cord-015684-q10sx1dm	771	47	P450	p450	JJ
cord-015684-q10sx1dm	771	48	polymorphisms	polymorphism	NNS
cord-015684-q10sx1dm	771	49	on	on	IN
cord-015684-q10sx1dm	771	50	drug	drug	NN
cord-015684-q10sx1dm	771	51	therapies	therapy	NNS
cord-015684-q10sx1dm	771	52	:	:	:
cord-015684-q10sx1dm	772	1	pharmacogenetic	pharmacogenetic	NNP
cord-015684-q10sx1dm	772	2	,	,	,
cord-015684-q10sx1dm	772	3	pharmacoepigenetic	pharmacoepigenetic	JJ
cord-015684-q10sx1dm	772	4	and	and	CC
cord-015684-q10sx1dm	772	5	clinical	clinical	JJ
cord-015684-q10sx1dm	772	6	aspects	aspect	NNS
cord-015684-q10sx1dm	772	7	Pharmaco	Pharmaco	NNP
cord-015684-q10sx1dm	772	8	-	-	HYPH
cord-015684-q10sx1dm	772	9	Genomics	Genomics	NNP
cord-015684-q10sx1dm	772	10	Handbook	Handbook	NNP
cord-015684-q10sx1dm	772	11	.	.	.
cord-015684-q10sx1dm	773	1	2nd	2nd	JJ
cord-015684-q10sx1dm	773	2	Edn	Edn	NNP
cord-015684-q10sx1dm	773	3	.	.	.
cord-015684-q10sx1dm	774	1	Lexi	Lexi	NNP
cord-015684-q10sx1dm	774	2	-	-	HYPH
cord-015684-q10sx1dm	774	3	Comp	Comp	NNP
cord-015684-q10sx1dm	774	4	Drug	Drug	NNP
cord-015684-q10sx1dm	774	5	Information	Information	NNP
cord-015684-q10sx1dm	774	6	Handbook	Handbook	NNP
cord-015684-q10sx1dm	774	7	with	with	IN
cord-015684-q10sx1dm	774	8	International	International	NNP
cord-015684-q10sx1dm	774	9	Trade	Trade	NNP
cord-015684-q10sx1dm	774	10	Names	Names	NNPS
cord-015684-q10sx1dm	774	11	Index	Index	NNP
cord-015684-q10sx1dm	774	12	.	.	.
cord-015684-q10sx1dm	775	1	17th	17th	JJ
cord-015684-q10sx1dm	775	2	Edn	Edn	NNP
cord-015684-q10sx1dm	775	3	.	.	.
cord-015684-q10sx1dm	776	1	Lexi	Lexi	NNP
cord-015684-q10sx1dm	776	2	-	-	HYPH
cord-015684-q10sx1dm	776	3	Comp	Comp	NNP
cord-015684-q10sx1dm	776	4	Drug	Drug	NNP
cord-015684-q10sx1dm	776	5	Information	Information	NNP
cord-015684-q10sx1dm	776	6	Handbook	Handbook	NNP
cord-015684-q10sx1dm	776	7	for	for	IN
cord-015684-q10sx1dm	776	8	Psychiatry	Psychiatry	NNP
cord-015684-q10sx1dm	776	9	.	.	.
cord-015684-q10sx1dm	777	1	6th	6th	JJ
cord-015684-q10sx1dm	777	2	Edn	Edn	NNP
cord-015684-q10sx1dm	777	3	.	.	.
cord-015684-q10sx1dm	778	1	Lexi	Lexi	NNP
cord-015684-q10sx1dm	778	2	-	-	HYPH
cord-015684-q10sx1dm	778	3	Comp	Comp	NNP
cord-015684-q10sx1dm	778	4	Pharmacogenomics	Pharmacogenomics	NNP
cord-015684-q10sx1dm	778	5	in	in	IN
cord-015684-q10sx1dm	778	6	schizophrenia	schizophrenia	NNP
cord-015684-q10sx1dm	778	7	:	:	:
cord-015684-q10sx1dm	778	8	the	the	DT
cord-015684-q10sx1dm	778	9	quest	quest	NN
cord-015684-q10sx1dm	778	10	for	for	IN
cord-015684-q10sx1dm	778	11	individualized	individualized	JJ
cord-015684-q10sx1dm	778	12	therapy	therapy	NN
cord-015684-q10sx1dm	779	1	The	the	DT
cord-015684-q10sx1dm	779	2	role	role	NN
cord-015684-q10sx1dm	779	3	of	of	IN
cord-015684-q10sx1dm	779	4	5-HT2C	5-ht2c	CD
cord-015684-q10sx1dm	779	5	receptor	receptor	NN
cord-015684-q10sx1dm	779	6	polymorphisms	polymorphism	NNS
cord-015684-q10sx1dm	779	7	in	in	IN
cord-015684-q10sx1dm	779	8	the	the	DT
cord-015684-q10sx1dm	779	9	pharmacogenetics	pharmacogenetic	NNS
cord-015684-q10sx1dm	779	10	of	of	IN
cord-015684-q10sx1dm	779	11	antipsychotic	antipsychotic	JJ
cord-015684-q10sx1dm	779	12	drug	drug	NN
cord-015684-q10sx1dm	779	13	treatment	treatment	NN
cord-015684-q10sx1dm	779	14	Dopamine	Dopamine	NNP
cord-015684-q10sx1dm	779	15	D4	D4	NNP
cord-015684-q10sx1dm	779	16	receptor	receptor	NN
cord-015684-q10sx1dm	779	17	gene	gene	NN
cord-015684-q10sx1dm	779	18	exon	exon	NN
cord-015684-q10sx1dm	779	19	III	iii	CD
cord-015684-q10sx1dm	779	20	polymorphism	polymorphism	NN
cord-015684-q10sx1dm	779	21	and	and	CC
cord-015684-q10sx1dm	779	22	interindividual	interindividual	JJ
cord-015684-q10sx1dm	779	23	variation	variation	NN
cord-015684-q10sx1dm	779	24	in	in	IN
cord-015684-q10sx1dm	779	25	response	response	NN
cord-015684-q10sx1dm	779	26	to	to	IN
cord-015684-q10sx1dm	779	27	clozapine	clozapine	NNP
cord-015684-q10sx1dm	779	28	Association	Association	NNP
cord-015684-q10sx1dm	779	29	between	between	IN
cord-015684-q10sx1dm	779	30	multidrug	multidrug	NN
cord-015684-q10sx1dm	779	31	resistance	resistance	NN
cord-015684-q10sx1dm	779	32	1	1	CD
cord-015684-q10sx1dm	780	1	(	(	-LRB-
cord-015684-q10sx1dm	780	2	MDR1	MDR1	NNP
cord-015684-q10sx1dm	780	3	)	)	-RRB-
cord-015684-q10sx1dm	780	4	gene	gene	NN
cord-015684-q10sx1dm	780	5	polymorphism	polymorphism	NN
cord-015684-q10sx1dm	780	6	and	and	CC
cord-015684-q10sx1dm	780	7	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	780	8	response	response	NN
cord-015684-q10sx1dm	780	9	to	to	IN
cord-015684-q10sx1dm	780	10	bromperidol	bromperidol	NNP
cord-015684-q10sx1dm	780	11	in	in	IN
cord-015684-q10sx1dm	780	12	schizophrenic	schizophrenic	JJ
cord-015684-q10sx1dm	780	13	patients	patient	NNS
cord-015684-q10sx1dm	780	14	:	:	:
cord-015684-q10sx1dm	780	15	a	a	DT
cord-015684-q10sx1dm	780	16	preliminary	preliminary	JJ
cord-015684-q10sx1dm	780	17	study	study	NN
cord-015684-q10sx1dm	780	18	Genetic	genetic	JJ
cord-015684-q10sx1dm	780	19	susceptibility	susceptibility	NN
cord-015684-q10sx1dm	780	20	to	to	IN
cord-015684-q10sx1dm	780	21	tardive	tardive	VB
cord-015684-q10sx1dm	780	22	dyskinesia	dyskinesia	NN
cord-015684-q10sx1dm	780	23	among	among	IN
cord-015684-q10sx1dm	780	24	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	780	25	subjects	subject	NNS
cord-015684-q10sx1dm	780	26	:	:	:
cord-015684-q10sx1dm	780	27	IV	IV	NNP
cord-015684-q10sx1dm	780	28	.	.	.
cord-015684-q10sx1dm	781	1	Role	role	NN
cord-015684-q10sx1dm	781	2	of	of	IN
cord-015684-q10sx1dm	781	3	dopaminergic	dopaminergic	JJ
cord-015684-q10sx1dm	781	4	pathway	pathway	NN
cord-015684-q10sx1dm	781	5	gene	gene	NN
cord-015684-q10sx1dm	781	6	polymorphisms	polymorphism	NNS
cord-015684-q10sx1dm	781	7	DRD2	DRD2	NNP
cord-015684-q10sx1dm	781	8	promoter	promoter	NN
cord-015684-q10sx1dm	781	9	region	region	NN
cord-015684-q10sx1dm	781	10	variation	variation	NN
cord-015684-q10sx1dm	781	11	as	as	IN
cord-015684-q10sx1dm	781	12	a	a	DT
cord-015684-q10sx1dm	781	13	predictor	predictor	NN
cord-015684-q10sx1dm	781	14	of	of	IN
cord-015684-q10sx1dm	781	15	sustained	sustained	JJ
cord-015684-q10sx1dm	781	16	response	response	NN
cord-015684-q10sx1dm	781	17	to	to	IN
cord-015684-q10sx1dm	781	18	antipsychotic	antipsychotic	JJ
cord-015684-q10sx1dm	781	19	medication	medication	NN
cord-015684-q10sx1dm	781	20	in	in	IN
cord-015684-q10sx1dm	781	21	fi	fi	NNP
cord-015684-q10sx1dm	781	22	rst	rst	NNP
cord-015684-q10sx1dm	781	23	-	-	HYPH
cord-015684-q10sx1dm	781	24	episode	episode	NN
cord-015684-q10sx1dm	781	25	schizophrenic	schizophrenic	JJ
cord-015684-q10sx1dm	781	26	patients	patient	NNS
cord-015684-q10sx1dm	782	1	The	the	DT
cord-015684-q10sx1dm	782	2	relationship	relationship	NN
cord-015684-q10sx1dm	782	3	between	between	IN
cord-015684-q10sx1dm	782	4	P	p	NN
cord-015684-q10sx1dm	782	5	-	-	HYPH
cord-015684-q10sx1dm	782	6	glycoprotein	glycoprotein	NN
cord-015684-q10sx1dm	782	7	(	(	-LRB-
cord-015684-q10sx1dm	782	8	PGP	PGP	NNP
cord-015684-q10sx1dm	782	9	)	)	-RRB-
cord-015684-q10sx1dm	782	10	polymorphisms	polymorphism	NNS
cord-015684-q10sx1dm	782	11	and	and	CC
cord-015684-q10sx1dm	782	12	response	response	NN
cord-015684-q10sx1dm	782	13	to	to	IN
cord-015684-q10sx1dm	782	14	olanzapine	olanzapine	NNP
cord-015684-q10sx1dm	782	15	treatment	treatment	NN
cord-015684-q10sx1dm	782	16	in	in	IN
cord-015684-q10sx1dm	782	17	schizophrenia	schizophrenia	NNP
cord-015684-q10sx1dm	783	1	Polymorphisms	polymorphism	NNS
cord-015684-q10sx1dm	783	2	of	of	IN
cord-015684-q10sx1dm	783	3	the	the	DT
cord-015684-q10sx1dm	783	4	ABCB1	ABCB1	NNP
cord-015684-q10sx1dm	783	5	gene	gene	NN
cord-015684-q10sx1dm	783	6	are	be	VBP
cord-015684-q10sx1dm	783	7	associated	associate	VBN
cord-015684-q10sx1dm	783	8	with	with	IN
cord-015684-q10sx1dm	783	9	the	the	DT
cord-015684-q10sx1dm	783	10	therapeutic	therapeutic	JJ
cord-015684-q10sx1dm	783	11	response	response	NN
cord-015684-q10sx1dm	783	12	to	to	IN
cord-015684-q10sx1dm	783	13	risperidone	risperidone	NN
cord-015684-q10sx1dm	783	14	in	in	IN
cord-015684-q10sx1dm	783	15	Chinese	chinese	JJ
cord-015684-q10sx1dm	783	16	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	783	17	patients	patient	NNS
cord-015684-q10sx1dm	783	18	Systematic	systematic	JJ
cord-015684-q10sx1dm	783	19	investigation	investigation	NN
cord-015684-q10sx1dm	783	20	of	of	IN
cord-015684-q10sx1dm	783	21	genetic	genetic	JJ
cord-015684-q10sx1dm	783	22	variability	variability	NN
cord-015684-q10sx1dm	783	23	in	in	IN
cord-015684-q10sx1dm	783	24	111	111	CD
cord-015684-q10sx1dm	783	25	human	human	JJ
cord-015684-q10sx1dm	783	26	genes	gene	NNS
cord-015684-q10sx1dm	783	27	-implications	-implication	NNS
cord-015684-q10sx1dm	783	28	for	for	IN
cord-015684-q10sx1dm	783	29	studying	study	VBG
cord-015684-q10sx1dm	783	30	variable	variable	JJ
cord-015684-q10sx1dm	783	31	drug	drug	NN
cord-015684-q10sx1dm	783	32	response	response	NN
cord-015684-q10sx1dm	783	33	Pharmacogenetics	Pharmacogenetics	NNP
cord-015684-q10sx1dm	783	34	of	of	IN
cord-015684-q10sx1dm	783	35	psychotropic	psychotropic	JJ
cord-015684-q10sx1dm	783	36	drug	drug	NN
cord-015684-q10sx1dm	783	37	response	response	NN
cord-015684-q10sx1dm	783	38	Individualizing	individualize	VBG
cord-015684-q10sx1dm	783	39	antipsychotic	antipsychotic	JJ
cord-015684-q10sx1dm	783	40	drug	drug	NN
cord-015684-q10sx1dm	783	41	therapy	therapy	NN
cord-015684-q10sx1dm	783	42	in	in	IN
cord-015684-q10sx1dm	783	43	schizophrenia	schizophrenia	NNP
cord-015684-q10sx1dm	783	44	:	:	:
cord-015684-q10sx1dm	783	45	the	the	DT
cord-015684-q10sx1dm	783	46	promise	promise	NN
cord-015684-q10sx1dm	783	47	of	of	IN
cord-015684-q10sx1dm	783	48	pharmacogenetics	pharmacogenetics	NNP
cord-015684-q10sx1dm	783	49	Pharmacogenetics	Pharmacogenetics	NNP
cord-015684-q10sx1dm	783	50	and	and	CC
cord-015684-q10sx1dm	783	51	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	783	52	Pharmacogenetics	Pharmacogenetics	NNP
cord-015684-q10sx1dm	783	53	and	and	CC
cord-015684-q10sx1dm	783	54	pharmacogenomics	pharmacogenomic	NNS
cord-015684-q10sx1dm	783	55	of	of	IN
cord-015684-q10sx1dm	783	56	schizophrenia	schizophrenia	NNP
cord-015684-q10sx1dm	783	57	:	:	:
cord-015684-q10sx1dm	783	58	a	a	DT
cord-015684-q10sx1dm	783	59	review	review	NN
cord-015684-q10sx1dm	783	60	of	of	IN
cord-015684-q10sx1dm	783	61	last	last	JJ
cord-015684-q10sx1dm	783	62	decade	decade	NN
cord-015684-q10sx1dm	783	63	of	of	IN
cord-015684-q10sx1dm	783	64	research	research	NN
cord-015684-q10sx1dm	783	65	Phosphodiesterase	Phosphodiesterase	NNP
cord-015684-q10sx1dm	783	66	genes	gene	NNS
cord-015684-q10sx1dm	783	67	are	be	VBP
cord-015684-q10sx1dm	783	68	associated	associate	VBN
cord-015684-q10sx1dm	783	69	with	with	IN
cord-015684-q10sx1dm	783	70	susceptibility	susceptibility	NN
cord-015684-q10sx1dm	783	71	to	to	IN
cord-015684-q10sx1dm	783	72	major	major	JJ
cord-015684-q10sx1dm	783	73	depression	depression	NN
cord-015684-q10sx1dm	783	74	and	and	CC
cord-015684-q10sx1dm	783	75	antidepressant	antidepressant	JJ
cord-015684-q10sx1dm	783	76	treatment	treatment	NN
cord-015684-q10sx1dm	783	77	response	response	NN
cord-015684-q10sx1dm	783	78	Variation	variation	NN
cord-015684-q10sx1dm	783	79	in	in	IN
cord-015684-q10sx1dm	783	80	the	the	DT
cord-015684-q10sx1dm	783	81	purinergic	purinergic	JJ
cord-015684-q10sx1dm	783	82	P2RX(7	P2RX(7	NNP
cord-015684-q10sx1dm	783	83	)	)	-RRB-
cord-015684-q10sx1dm	783	84	receptor	receptor	NN
cord-015684-q10sx1dm	783	85	gene	gene	NN
cord-015684-q10sx1dm	783	86	and	and	CC
cord-015684-q10sx1dm	783	87	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	784	1	The	the	DT
cord-015684-q10sx1dm	784	2	CNR1	CNR1	NNP
cord-015684-q10sx1dm	784	3	gene	gene	NN
cord-015684-q10sx1dm	784	4	as	as	IN
cord-015684-q10sx1dm	784	5	a	a	DT
cord-015684-q10sx1dm	784	6	pharmacogenetic	pharmacogenetic	JJ
cord-015684-q10sx1dm	784	7	factor	factor	NN
cord-015684-q10sx1dm	784	8	for	for	IN
cord-015684-q10sx1dm	784	9	antipsychotics	antipsychotic	NNS
cord-015684-q10sx1dm	784	10	rather	rather	RB
cord-015684-q10sx1dm	784	11	than	than	IN
cord-015684-q10sx1dm	784	12	a	a	DT
cord-015684-q10sx1dm	784	13	susceptibility	susceptibility	NN
cord-015684-q10sx1dm	784	14	gene	gene	NN
cord-015684-q10sx1dm	784	15	for	for	IN
cord-015684-q10sx1dm	784	16	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	784	17	Druginduced	Druginduced	NNP
cord-015684-q10sx1dm	784	18	activation	activation	NN
cord-015684-q10sx1dm	784	19	of	of	IN
cord-015684-q10sx1dm	784	20	SREP	SREP	NNP
cord-015684-q10sx1dm	784	21	-	-	HYPH
cord-015684-q10sx1dm	784	22	controlled	control	VBN
cord-015684-q10sx1dm	784	23	lipogenic	lipogenic	JJ
cord-015684-q10sx1dm	784	24	gene	gene	NN
cord-015684-q10sx1dm	784	25	expression	expression	NN
cord-015684-q10sx1dm	784	26	in	in	IN
cord-015684-q10sx1dm	784	27	CNS	CNS	NNP
cord-015684-q10sx1dm	784	28	-	-	HYPH
cord-015684-q10sx1dm	784	29	related	relate	VBN
cord-015684-q10sx1dm	784	30	cell	cell	NN
cord-015684-q10sx1dm	784	31	lines	line	NNS
cord-015684-q10sx1dm	784	32	:	:	:
cord-015684-q10sx1dm	784	33	marked	mark	VBN
cord-015684-q10sx1dm	784	34	differences	difference	NNS
cord-015684-q10sx1dm	784	35	between	between	IN
cord-015684-q10sx1dm	784	36	various	various	JJ
cord-015684-q10sx1dm	784	37	antipsychotic	antipsychotic	JJ
cord-015684-q10sx1dm	784	38	drugs	drug	NNS
cord-015684-q10sx1dm	784	39	Further	further	JJ
cord-015684-q10sx1dm	784	40	evidence	evidence	NN
cord-015684-q10sx1dm	784	41	for	for	IN
cord-015684-q10sx1dm	784	42	association	association	NN
cord-015684-q10sx1dm	784	43	of	of	IN
cord-015684-q10sx1dm	784	44	the	the	DT
cord-015684-q10sx1dm	784	45	RGS2	RGS2	NNP
cord-015684-q10sx1dm	784	46	gene	gene	NN
cord-015684-q10sx1dm	784	47	with	with	IN
cord-015684-q10sx1dm	784	48	antipsychoticinduced	antipsychoticinduced	JJ
cord-015684-q10sx1dm	784	49	parkinsonism	parkinsonism	NN
cord-015684-q10sx1dm	784	50	:	:	:
cord-015684-q10sx1dm	784	51	protective	protective	JJ
cord-015684-q10sx1dm	784	52	role	role	NN
cord-015684-q10sx1dm	784	53	of	of	IN
cord-015684-q10sx1dm	784	54	a	a	DT
cord-015684-q10sx1dm	784	55	functional	functional	JJ
cord-015684-q10sx1dm	784	56	polymorphism	polymorphism	NN
cord-015684-q10sx1dm	784	57	in	in	IN
cord-015684-q10sx1dm	784	58	the	the	DT
cord-015684-q10sx1dm	784	59	3′-untranslated	3′-untranslated	CD
cord-015684-q10sx1dm	784	60	region	region	NN
cord-015684-q10sx1dm	784	61	Ethnic	ethnic	JJ
cord-015684-q10sx1dm	784	62	stratifi	stratifi	NNP
cord-015684-q10sx1dm	784	63	cation	cation	NN
cord-015684-q10sx1dm	784	64	of	of	IN
cord-015684-q10sx1dm	784	65	the	the	DT
cord-015684-q10sx1dm	784	66	association	association	NNP
cord-015684-q10sx1dm	784	67	of	of	IN
cord-015684-q10sx1dm	784	68	RGS4	RGS4	NNP
cord-015684-q10sx1dm	784	69	variants	variant	NNS
cord-015684-q10sx1dm	784	70	with	with	IN
cord-015684-q10sx1dm	784	71	antipsychotic	antipsychotic	JJ
cord-015684-q10sx1dm	784	72	treatment	treatment	NN
cord-015684-q10sx1dm	784	73	response	response	NN
cord-015684-q10sx1dm	784	74	in	in	IN
cord-015684-q10sx1dm	784	75	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	784	76	Pharmacogenetic	Pharmacogenetic	NNP
cord-015684-q10sx1dm	784	77	assessment	assessment	NN
cord-015684-q10sx1dm	784	78	of	of	IN
cord-015684-q10sx1dm	784	79	antipsychotic	antipsychotic	NN
cord-015684-q10sx1dm	784	80	-	-	HYPH
cord-015684-q10sx1dm	784	81	induced	induce	VBN
cord-015684-q10sx1dm	784	82	movement	movement	NN
cord-015684-q10sx1dm	784	83	disorders	disorder	NNS
cord-015684-q10sx1dm	784	84	:	:	:
cord-015684-q10sx1dm	784	85	contribution	contribution	NN
cord-015684-q10sx1dm	784	86	of	of	IN
cord-015684-q10sx1dm	784	87	the	the	DT
cord-015684-q10sx1dm	784	88	dopamine	dopamine	NN
cord-015684-q10sx1dm	784	89	D3	D3	NNP
cord-015684-q10sx1dm	784	90	receptor	receptor	NN
cord-015684-q10sx1dm	784	91	and	and	CC
cord-015684-q10sx1dm	784	92	cytochrome	cytochrome	NN
cord-015684-q10sx1dm	784	93	P450	P450	NNP
cord-015684-q10sx1dm	784	94	1A2	1a2	CD
cord-015684-q10sx1dm	784	95	genes	gene	NNS
cord-015684-q10sx1dm	784	96	Association	Association	NNP
cord-015684-q10sx1dm	784	97	between	between	IN
cord-015684-q10sx1dm	784	98	CYP2D6	CYP2D6	NNP
cord-015684-q10sx1dm	784	99	genotype	genotype	NN
cord-015684-q10sx1dm	784	100	and	and	CC
cord-015684-q10sx1dm	784	101	tardive	tardive	NN
cord-015684-q10sx1dm	784	102	dyskinesia	dyskinesia	NN
cord-015684-q10sx1dm	784	103	in	in	IN
cord-015684-q10sx1dm	784	104	Korean	korean	JJ
cord-015684-q10sx1dm	784	105	schizophrenics	schizophrenic	NNS
cord-015684-q10sx1dm	784	106	Haplotype	Haplotype	NNP
cord-015684-q10sx1dm	784	107	analysis	analysis	NN
cord-015684-q10sx1dm	784	108	of	of	IN
cord-015684-q10sx1dm	784	109	endothelial	endothelial	JJ
cord-015684-q10sx1dm	784	110	nitric	nitric	JJ
cord-015684-q10sx1dm	784	111	oxide	oxide	NN
cord-015684-q10sx1dm	784	112	synthase	synthase	NN
cord-015684-q10sx1dm	784	113	(	(	-LRB-
cord-015684-q10sx1dm	784	114	NOS3	nos3	JJ
cord-015684-q10sx1dm	784	115	)	)	-RRB-
cord-015684-q10sx1dm	784	116	genetic	genetic	JJ
cord-015684-q10sx1dm	784	117	variants	variant	NNS
cord-015684-q10sx1dm	784	118	and	and	CC
cord-015684-q10sx1dm	784	119	tardive	tardive	NN
cord-015684-q10sx1dm	784	120	dyskinesia	dyskinesia	NN
cord-015684-q10sx1dm	784	121	in	in	IN
cord-015684-q10sx1dm	784	122	patients	patient	NNS
cord-015684-q10sx1dm	784	123	with	with	IN
cord-015684-q10sx1dm	784	124	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	784	125	Could	Could	MD
cord-015684-q10sx1dm	785	1	HTR2A	htr2a	CD
cord-015684-q10sx1dm	785	2	T102C	t102c	JJ
cord-015684-q10sx1dm	785	3	and	and	CC
cord-015684-q10sx1dm	785	4	DRD3	DRD3	NNP
cord-015684-q10sx1dm	785	5	Ser9Gly	Ser9Gly	NNP
cord-015684-q10sx1dm	785	6	predict	predict	VBP
cord-015684-q10sx1dm	785	7	clinical	clinical	JJ
cord-015684-q10sx1dm	785	8	improvement	improvement	NN
cord-015684-q10sx1dm	785	9	in	in	IN
cord-015684-q10sx1dm	785	10	patients	patient	NNS
cord-015684-q10sx1dm	785	11	with	with	IN
cord-015684-q10sx1dm	785	12	acutely	acutely	RB
cord-015684-q10sx1dm	785	13	exacerbated	exacerbate	VBN
cord-015684-q10sx1dm	785	14	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	785	15	?	?	.
cord-015684-q10sx1dm	786	1	Results	result	NNS
cord-015684-q10sx1dm	786	2	from	from	IN
cord-015684-q10sx1dm	786	3	treatment	treatment	NN
cord-015684-q10sx1dm	786	4	responses	response	NNS
cord-015684-q10sx1dm	786	5	to	to	IN
cord-015684-q10sx1dm	786	6	risperidone	risperidone	NN
cord-015684-q10sx1dm	786	7	in	in	IN
cord-015684-q10sx1dm	786	8	a	a	DT
cord-015684-q10sx1dm	786	9	naturalistic	naturalistic	JJ
cord-015684-q10sx1dm	786	10	setting	set	VBG
cord-015684-q10sx1dm	786	11	The	the	DT
cord-015684-q10sx1dm	786	12	-1019	-1019	NN
cord-015684-q10sx1dm	786	13	C	C	NNP
cord-015684-q10sx1dm	786	14	/	/	SYM
cord-015684-q10sx1dm	786	15	G	g	NN
cord-015684-q10sx1dm	786	16	polymorphism	polymorphism	NN
cord-015684-q10sx1dm	786	17	of	of	IN
cord-015684-q10sx1dm	786	18	the	the	DT
cord-015684-q10sx1dm	786	19	5-HT1A	5-HT1A	NNP
cord-015684-q10sx1dm	786	20	receptor	receptor	NN
cord-015684-q10sx1dm	786	21	gene	gene	NN
cord-015684-q10sx1dm	786	22	is	be	VBZ
cord-015684-q10sx1dm	786	23	associated	associate	VBN
cord-015684-q10sx1dm	786	24	with	with	IN
cord-015684-q10sx1dm	786	25	negative	negative	JJ
cord-015684-q10sx1dm	786	26	symptom	symptom	NN
cord-015684-q10sx1dm	786	27	response	response	NN
cord-015684-q10sx1dm	786	28	to	to	IN
cord-015684-q10sx1dm	786	29	risperidone	risperidone	NNP
cord-015684-q10sx1dm	786	30	treatment	treatment	NN
cord-015684-q10sx1dm	786	31	in	in	IN
cord-015684-q10sx1dm	786	32	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	786	33	patients	patient	NNS
cord-015684-q10sx1dm	786	34	Interaction	Interaction	NNP
cord-015684-q10sx1dm	786	35	between	between	IN
cord-015684-q10sx1dm	786	36	NOTCH4	NOTCH4	NNP
cord-015684-q10sx1dm	786	37	and	and	CC
cord-015684-q10sx1dm	786	38	catechol	catechol	NN
cord-015684-q10sx1dm	786	39	-	-	HYPH
cord-015684-q10sx1dm	786	40	O	o	NN
cord-015684-q10sx1dm	786	41	-	-	HYPH
cord-015684-q10sx1dm	786	42	methyltransferase	methyltransferase	NN
cord-015684-q10sx1dm	786	43	genotypes	genotype	NNS
cord-015684-q10sx1dm	786	44	in	in	IN
cord-015684-q10sx1dm	786	45	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	786	46	patients	patient	NNS
cord-015684-q10sx1dm	786	47	with	with	IN
cord-015684-q10sx1dm	786	48	poor	poor	JJ
cord-015684-q10sx1dm	786	49	response	response	NN
cord-015684-q10sx1dm	786	50	to	to	IN
cord-015684-q10sx1dm	786	51	typical	typical	JJ
cord-015684-q10sx1dm	786	52	neuroleptics	neuroleptic	NNS
cord-015684-q10sx1dm	786	53	Effect	effect	NN
cord-015684-q10sx1dm	786	54	of	of	IN
cord-015684-q10sx1dm	786	55	a	a	DT
cord-015684-q10sx1dm	786	56	ciliary	ciliary	NN
cord-015684-q10sx1dm	786	57	neurotrophic	neurotrophic	NN
cord-015684-q10sx1dm	786	58	factor	factor	NN
cord-015684-q10sx1dm	786	59	polymorphism	polymorphism	NN
cord-015684-q10sx1dm	786	60	on	on	IN
cord-015684-q10sx1dm	786	61	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	786	62	symptom	symptom	NN
cord-015684-q10sx1dm	786	63	improvement	improvement	NN
cord-015684-q10sx1dm	786	64	in	in	IN
cord-015684-q10sx1dm	786	65	an	an	DT
cord-015684-q10sx1dm	786	66	iloperidone	iloperidone	JJ
cord-015684-q10sx1dm	786	67	clinical	clinical	JJ
cord-015684-q10sx1dm	786	68	trial	trial	NNP
cord-015684-q10sx1dm	786	69	Association	Association	NNP
cord-015684-q10sx1dm	786	70	of	of	IN
cord-015684-q10sx1dm	786	71	the	the	DT
cord-015684-q10sx1dm	786	72	dopamine	dopamine	NN
cord-015684-q10sx1dm	786	73	receptor	receptor	NN
cord-015684-q10sx1dm	786	74	interacting	interact	VBG
cord-015684-q10sx1dm	786	75	protein	protein	NN
cord-015684-q10sx1dm	786	76	gene	gene	NN
cord-015684-q10sx1dm	786	77	,	,	,
cord-015684-q10sx1dm	786	78	NEF3	NEF3	NNP
cord-015684-q10sx1dm	786	79	,	,	,
cord-015684-q10sx1dm	786	80	with	with	IN
cord-015684-q10sx1dm	786	81	early	early	JJ
cord-015684-q10sx1dm	786	82	response	response	NN
cord-015684-q10sx1dm	786	83	to	to	IN
cord-015684-q10sx1dm	786	84	antipsychotic	antipsychotic	JJ
cord-015684-q10sx1dm	786	85	medication	medication	NN
cord-015684-q10sx1dm	786	86	Pharmacogenetic	Pharmacogenetic	NNP
cord-015684-q10sx1dm	786	87	study	study	NN
cord-015684-q10sx1dm	786	88	of	of	IN
cord-015684-q10sx1dm	786	89	atypical	atypical	JJ
cord-015684-q10sx1dm	786	90	antipsychotic	antipsychotic	JJ
cord-015684-q10sx1dm	786	91	drug	drug	NN
cord-015684-q10sx1dm	786	92	response	response	NN
cord-015684-q10sx1dm	786	93	:	:	:
cord-015684-q10sx1dm	786	94	involvement	involvement	NN
cord-015684-q10sx1dm	786	95	of	of	IN
cord-015684-q10sx1dm	786	96	the	the	DT
cord-015684-q10sx1dm	786	97	norepinephrine	norepinephrine	NNP
cord-015684-q10sx1dm	786	98	transporter	transporter	NN
cord-015684-q10sx1dm	786	99	gene	gene	NNP
cord-015684-q10sx1dm	786	100	Association	Association	NNP
cord-015684-q10sx1dm	786	101	of	of	IN
cord-015684-q10sx1dm	786	102	clozapineinduced	clozapineinduced	NNP
cord-015684-q10sx1dm	786	103	weight	weight	NN
cord-015684-q10sx1dm	786	104	gain	gain	NN
cord-015684-q10sx1dm	786	105	with	with	IN
cord-015684-q10sx1dm	786	106	a	a	DT
cord-015684-q10sx1dm	786	107	polymorphism	polymorphism	NN
cord-015684-q10sx1dm	786	108	in	in	IN
cord-015684-q10sx1dm	786	109	the	the	DT
cord-015684-q10sx1dm	786	110	leptin	leptin	NN
cord-015684-q10sx1dm	786	111	promoter	promoter	NN
cord-015684-q10sx1dm	786	112	region	region	NN
cord-015684-q10sx1dm	786	113	in	in	IN
cord-015684-q10sx1dm	786	114	patients	patient	NNS
cord-015684-q10sx1dm	786	115	with	with	IN
cord-015684-q10sx1dm	786	116	chronic	chronic	JJ
cord-015684-q10sx1dm	786	117	schizophrenia	schizophrenia	NN
cord-015684-q10sx1dm	786	118	in	in	IN
cord-015684-q10sx1dm	786	119	a	a	DT
cord-015684-q10sx1dm	786	120	Chinese	chinese	JJ
cord-015684-q10sx1dm	786	121	population	population	NN
cord-015684-q10sx1dm	786	122	Leptin	leptin	NN
cord-015684-q10sx1dm	786	123	and	and	CC
cord-015684-q10sx1dm	786	124	leptin	leptin	NN
cord-015684-q10sx1dm	786	125	receptor	receptor	NN
cord-015684-q10sx1dm	786	126	gene	gene	NN
cord-015684-q10sx1dm	786	127	polymorphisms	polymorphism	NNS
cord-015684-q10sx1dm	786	128	and	and	CC
cord-015684-q10sx1dm	786	129	increases	increase	NNS
cord-015684-q10sx1dm	786	130	in	in	IN
cord-015684-q10sx1dm	786	131	body	body	NN
cord-015684-q10sx1dm	786	132	mass	mass	NN
cord-015684-q10sx1dm	786	133	index	index	NN
cord-015684-q10sx1dm	786	134	(	(	-LRB-
cord-015684-q10sx1dm	786	135	BMI	BMI	NNP
cord-015684-q10sx1dm	786	136	)	)	-RRB-
cord-015684-q10sx1dm	786	137	from	from	IN
cord-015684-q10sx1dm	786	138	olanzapine	olanzapine	JJ
cord-015684-q10sx1dm	786	139	treatment	treatment	NN
cord-015684-q10sx1dm	786	140	in	in	IN
cord-015684-q10sx1dm	786	141	persons	person	NNS
cord-015684-q10sx1dm	786	142	with	with	IN
cord-015684-q10sx1dm	786	143	schizophrenia	schizophrenia	NNP
cord-015684-q10sx1dm	786	144	Polymorphisms	Polymorphisms	NNP
cord-015684-q10sx1dm	786	145	of	of	IN
cord-015684-q10sx1dm	786	146	the	the	DT
cord-015684-q10sx1dm	786	147	5-HT2C	5-ht2c	CD
cord-015684-q10sx1dm	786	148	receptor	receptor	NN
cord-015684-q10sx1dm	786	149	and	and	CC
cord-015684-q10sx1dm	786	150	leptin	leptin	NN
cord-015684-q10sx1dm	786	151	genes	gene	NNS
cord-015684-q10sx1dm	786	152	are	be	VBP
cord-015684-q10sx1dm	786	153	associated	associate	VBN
cord-015684-q10sx1dm	786	154	with	with	IN
cord-015684-q10sx1dm	786	155	antipsychotic	antipsychotic	JJ
cord-015684-q10sx1dm	786	156	drug	drug	NN
cord-015684-q10sx1dm	786	157	-	-	HYPH
cord-015684-q10sx1dm	786	158	induced	induce	VBN
cord-015684-q10sx1dm	786	159	weight	weight	NN
cord-015684-q10sx1dm	786	160	gain	gain	NN
cord-015684-q10sx1dm	786	161	in	in	IN
cord-015684-q10sx1dm	786	162	Caucasian	caucasian	JJ
cord-015684-q10sx1dm	786	163	subjects	subject	NNS
cord-015684-q10sx1dm	786	164	with	with	IN
cord-015684-q10sx1dm	786	165	a	a	DT
cord-015684-q10sx1dm	786	166	fi	fi	NN
cord-015684-q10sx1dm	786	167	rst	rst	NN
cord-015684-q10sx1dm	786	168	-	-	HYPH
cord-015684-q10sx1dm	786	169	episode	episode	NN
cord-015684-q10sx1dm	786	170	psicosis	psicosis	NNP
cord-015684-q10sx1dm	786	171	Transcriptional	Transcriptional	NNP
cord-015684-q10sx1dm	786	172	profi	profi	NNP
cord-015684-q10sx1dm	786	173	ling	ling	NNP
cord-015684-q10sx1dm	786	174	of	of	IN
cord-015684-q10sx1dm	786	175	the	the	DT
cord-015684-q10sx1dm	786	176	rat	rat	NNP
cord-015684-q10sx1dm	786	177	frontal	frontal	JJ
cord-015684-q10sx1dm	786	178	cortex	cortex	NNP
cord-015684-q10sx1dm	786	179	following	follow	VBG
cord-015684-q10sx1dm	786	180	administration	administration	NN
cord-015684-q10sx1dm	786	181	of	of	IN
cord-015684-q10sx1dm	786	182	the	the	DT
cord-015684-q10sx1dm	786	183	mGlu5	mGlu5	NNP
cord-015684-q10sx1dm	786	184	antagonists	antagonist	NNS
cord-015684-q10sx1dm	786	185	MPEP	MPEP	NNP
cord-015684-q10sx1dm	786	186	and	and	CC
cord-015684-q10sx1dm	786	187	MTEP	MTEP	NNP
cord-015684-q10sx1dm	786	188	Association	Association	NNP
cord-015684-q10sx1dm	786	189	of	of	IN
cord-015684-q10sx1dm	786	190	GRIK4	GRIK4	NNP
cord-015684-q10sx1dm	786	191	with	with	IN
cord-015684-q10sx1dm	786	192	outcome	outcome	NN
cord-015684-q10sx1dm	786	193	of	of	IN
cord-015684-q10sx1dm	786	194	antidepressant	antidepressant	JJ
cord-015684-q10sx1dm	786	195	treatment	treatment	NN
cord-015684-q10sx1dm	786	196	in	in	IN
cord-015684-q10sx1dm	786	197	the	the	DT
cord-015684-q10sx1dm	786	198	STAR	star	NN
cord-015684-q10sx1dm	786	199	*	*	NFP
cord-015684-q10sx1dm	786	200	D	D	NNP
cord-015684-q10sx1dm	786	201	cohort	cohort	NN
cord-015684-q10sx1dm	786	202	Glycogen	Glycogen	NNP
cord-015684-q10sx1dm	786	203	synthase	synthase	NN
cord-015684-q10sx1dm	786	204	kinase-3beta	kinase-3beta	NN
cord-015684-q10sx1dm	786	205	gene	gene	NN
cord-015684-q10sx1dm	786	206	is	be	VBZ
cord-015684-q10sx1dm	786	207	associated	associate	VBN
cord-015684-q10sx1dm	786	208	with	with	IN
cord-015684-q10sx1dm	786	209	antidepressant	antidepressant	JJ
cord-015684-q10sx1dm	786	210	treatment	treatment	NN
cord-015684-q10sx1dm	786	211	response	response	NN
cord-015684-q10sx1dm	786	212	in	in	IN
cord-015684-q10sx1dm	786	213	Chinese	chinese	JJ
cord-015684-q10sx1dm	786	214	major	major	JJ
cord-015684-q10sx1dm	786	215	depressive	depressive	JJ
cord-015684-q10sx1dm	786	216	disorder	disorder	NN
cord-015684-q10sx1dm	786	217	Lithium	Lithium	NNP
cord-015684-q10sx1dm	786	218	response	response	NN
cord-015684-q10sx1dm	786	219	and	and	CC
cord-015684-q10sx1dm	786	220	genetic	genetic	JJ
cord-015684-q10sx1dm	786	221	variation	variation	NN
cord-015684-q10sx1dm	786	222	in	in	IN
cord-015684-q10sx1dm	786	223	the	the	DT
cord-015684-q10sx1dm	786	224	CREB	CREB	NNP
cord-015684-q10sx1dm	786	225	family	family	NN
cord-015684-q10sx1dm	786	226	of	of	IN
cord-015684-q10sx1dm	786	227	genes	gene	NNS
cord-015684-q10sx1dm	787	1	The	the	DT
cord-015684-q10sx1dm	787	2	medial	medial	JJ
cord-015684-q10sx1dm	787	3	and	and	CC
cord-015684-q10sx1dm	787	4	lateral	lateral	JJ
cord-015684-q10sx1dm	787	5	substantia	substantia	NN
cord-015684-q10sx1dm	787	6	nigra	nigra	NN
cord-015684-q10sx1dm	787	7	in	in	IN
cord-015684-q10sx1dm	787	8	Parkinson	Parkinson	NNP
cord-015684-q10sx1dm	787	9	's	's	POS
cord-015684-q10sx1dm	787	10	disease	disease	NN
cord-015684-q10sx1dm	787	11	:	:	:
cord-015684-q10sx1dm	788	1	mRNA	mRNA	NNP
cord-015684-q10sx1dm	788	2	profi	profi	NNP
cord-015684-q10sx1dm	788	3	les	les	NNP
cord-015684-q10sx1dm	788	4	associated	associate	VBN
cord-015684-q10sx1dm	788	5	with	with	IN
cord-015684-q10sx1dm	788	6	higher	high	JJR
cord-015684-q10sx1dm	788	7	brain	brain	NN
cord-015684-q10sx1dm	788	8	tissue	tissue	NN
cord-015684-q10sx1dm	788	9	vulnerability	vulnerability	NN
cord-015684-q10sx1dm	788	10	Phosphoproteome	Phosphoproteome	NNP
cord-015684-q10sx1dm	788	11	and	and	CC
cord-015684-q10sx1dm	788	12	transcriptome	transcriptome	NN
cord-015684-q10sx1dm	788	13	analysis	analysis	NN
cord-015684-q10sx1dm	788	14	of	of	IN
cord-015684-q10sx1dm	788	15	the	the	DT
cord-015684-q10sx1dm	788	16	neuronal	neuronal	JJ
cord-015684-q10sx1dm	788	17	response	response	NN
cord-015684-q10sx1dm	788	18	to	to	IN
cord-015684-q10sx1dm	788	19	a	a	DT
cord-015684-q10sx1dm	788	20	CDK5	CDK5	NNP
cord-015684-q10sx1dm	788	21	inhibitor	inhibitor	NN
cord-015684-q10sx1dm	788	22	Allelic	Allelic	NNP
cord-015684-q10sx1dm	788	23	mRNA	mRNA	NNP
cord-015684-q10sx1dm	788	24	expression	expression	NN
cord-015684-q10sx1dm	788	25	of	of	IN
cord-015684-q10sx1dm	788	26	X	x	NN
cord-015684-q10sx1dm	788	27	-	-	HYPH
cord-015684-q10sx1dm	788	28	linked	link	VBN
cord-015684-q10sx1dm	788	29	monoamine	monoamine	NN
cord-015684-q10sx1dm	788	30	oxidase	oxidase	NN
cord-015684-q10sx1dm	788	31	A	a	NN
cord-015684-q10sx1dm	788	32	(	(	-LRB-
cord-015684-q10sx1dm	788	33	MAOA	MAOA	NNP
cord-015684-q10sx1dm	788	34	)	)	-RRB-
cord-015684-q10sx1dm	788	35	in	in	IN
cord-015684-q10sx1dm	788	36	human	human	JJ
cord-015684-q10sx1dm	788	37	brain	brain	NN
cord-015684-q10sx1dm	788	38	:	:	:
cord-015684-q10sx1dm	788	39	dissection	dissection	NN
cord-015684-q10sx1dm	788	40	of	of	IN
cord-015684-q10sx1dm	788	41	epigenetic	epigenetic	JJ
cord-015684-q10sx1dm	788	42	and	and	CC
cord-015684-q10sx1dm	788	43	genetic	genetic	JJ
cord-015684-q10sx1dm	788	44	factors	factor	NNS
cord-015684-q10sx1dm	788	45	Epigenetics	epigenetic	NNS
cord-015684-q10sx1dm	788	46	and	and	CC
cord-015684-q10sx1dm	788	47	its	-PRON-	PRP$
cord-015684-q10sx1dm	788	48	implications	implication	NNS
cord-015684-q10sx1dm	788	49	for	for	IN
cord-015684-q10sx1dm	788	50	behavioural	behavioural	JJ
cord-015684-q10sx1dm	788	51	neuroendocrinology	neuroendocrinology	NN
cord-015684-q10sx1dm	788	52	Antineoplastic	antineoplastic	JJ
cord-015684-q10sx1dm	788	53	effects	effect	NNS
cord-015684-q10sx1dm	788	54	of	of	IN
cord-015684-q10sx1dm	788	55	the	the	DT
cord-015684-q10sx1dm	788	56	DNA	dna	NN
cord-015684-q10sx1dm	788	57	methylation	methylation	NN
cord-015684-q10sx1dm	788	58	inhibitor	inhibitor	NN
cord-015684-q10sx1dm	788	59	hydralazine	hydralazine	NNP
cord-015684-q10sx1dm	788	60	and	and	CC
cord-015684-q10sx1dm	788	61	the	the	DT
cord-015684-q10sx1dm	788	62	histone	histone	NN
cord-015684-q10sx1dm	788	63	deacetylase	deacetylase	NN
cord-015684-q10sx1dm	788	64	inhibitor	inhibitor	NN
cord-015684-q10sx1dm	788	65	valproic	valproic	NN
cord-015684-q10sx1dm	788	66	acid	acid	NN
cord-015684-q10sx1dm	788	67	in	in	IN
cord-015684-q10sx1dm	788	68	cancer	cancer	NN
cord-015684-q10sx1dm	788	69	cell	cell	NN
cord-015684-q10sx1dm	788	70	lines	line	NNS
cord-015684-q10sx1dm	789	1	Epigenetic	epigenetic	JJ
cord-015684-q10sx1dm	789	2	alterations	alteration	NNS
cord-015684-q10sx1dm	789	3	of	of	IN
cord-015684-q10sx1dm	789	4	the	the	DT
cord-015684-q10sx1dm	789	5	dopaminergic	dopaminergic	JJ
cord-015684-q10sx1dm	789	6	system	system	NN
cord-015684-q10sx1dm	789	7	in	in	IN
cord-015684-q10sx1dm	789	8	major	major	JJ
cord-015684-q10sx1dm	789	9	psychiatric	psychiatric	JJ
cord-015684-q10sx1dm	789	10	disorders	disorder	NNS
cord-015684-q10sx1dm	789	11	Central	central	JJ
cord-015684-q10sx1dm	789	12	Nervous	nervous	JJ
cord-015684-q10sx1dm	789	13	system	system	NN
cord-015684-q10sx1dm	789	14	drug	drug	NN
cord-015684-q10sx1dm	789	15	development	development	NN
cord-015684-q10sx1dm	789	16	:	:	:
cord-015684-q10sx1dm	789	17	an	an	DT
cord-015684-q10sx1dm	789	18	integrative	integrative	JJ
cord-015684-q10sx1dm	789	19	biomarker	biomarker	NN
cord-015684-q10sx1dm	789	20	approach	approach	NN
cord-015684-q10sx1dm	789	21	toward	toward	IN
cord-015684-q10sx1dm	789	22	individualized	individualized	JJ
cord-015684-q10sx1dm	789	23	medicine	medicine	NN
cord-015684-q10sx1dm	789	24	Pleiotropic	Pleiotropic	NNP
cord-015684-q10sx1dm	789	25	effects	effect	NNS
cord-015684-q10sx1dm	789	26	of	of	IN
cord-015684-q10sx1dm	789	27	APOE	APOE	NNP
cord-015684-q10sx1dm	789	28	in	in	IN
cord-015684-q10sx1dm	789	29	dementia	dementia	NN
cord-015684-q10sx1dm	789	30	:	:	:
cord-015684-q10sx1dm	789	31	infl	infl	NNP
cord-015684-q10sx1dm	789	32	uence	uence	NN
cord-015684-q10sx1dm	789	33	on	on	IN
cord-015684-q10sx1dm	789	34	functional	functional	JJ
cord-015684-q10sx1dm	789	35	genomics	genomic	NNS
cord-015684-q10sx1dm	789	36	and	and	CC
cord-015684-q10sx1dm	789	37	pharmacogenetics	pharmacogenetic	NNS
cord-015684-q10sx1dm	789	38	.	.	.
cord-015684-q10sx1dm	790	1	In	in	IN
cord-015684-q10sx1dm	790	2	:	:	:
cord-015684-q10sx1dm	790	3	Advances	advance	NNS
cord-015684-q10sx1dm	790	4	in	in	IN
cord-015684-q10sx1dm	790	5	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	790	6	's	's	POS
cord-015684-q10sx1dm	790	7	and	and	CC
cord-015684-q10sx1dm	790	8	Parkinson	Parkinson	NNP
cord-015684-q10sx1dm	790	9	's	's	POS
cord-015684-q10sx1dm	790	10	disease	disease	NN
cord-015684-q10sx1dm	790	11	.	.	.
cord-015684-q10sx1dm	791	1	Insights	insight	NNS
cord-015684-q10sx1dm	791	2	,	,	,
cord-015684-q10sx1dm	791	3	Progress	Progress	NNP
cord-015684-q10sx1dm	791	4	,	,	,
cord-015684-q10sx1dm	791	5	and	and	CC
cord-015684-q10sx1dm	791	6	Perspectives	Perspectives	NNPS
cord-015684-q10sx1dm	791	7	APOE	APOE	NNP
cord-015684-q10sx1dm	791	8	-	-	HYPH
cord-015684-q10sx1dm	791	9	Related	relate	VBN
cord-015684-q10sx1dm	791	10	dementia	dementia	NN
cord-015684-q10sx1dm	791	11	symptoms	symptom	NNS
cord-015684-q10sx1dm	791	12	:	:	:
cord-015684-q10sx1dm	791	13	frequency	frequency	NN
cord-015684-q10sx1dm	791	14	and	and	CC
cord-015684-q10sx1dm	791	15	progression	progression	NN
cord-015684-q10sx1dm	791	16	APOE	APOE	NNS
cord-015684-q10sx1dm	791	17	-	-	HYPH
cord-015684-q10sx1dm	791	18	Related	relate	VBN
cord-015684-q10sx1dm	791	19	frequency	frequency	NN
cord-015684-q10sx1dm	791	20	of	of	IN
cord-015684-q10sx1dm	791	21	cognitive	cognitive	JJ
cord-015684-q10sx1dm	791	22	and	and	CC
cord-015684-q10sx1dm	791	23	noncognitive	noncognitive	JJ
cord-015684-q10sx1dm	791	24	symptoms	symptom	NNS
cord-015684-q10sx1dm	791	25	in	in	IN
cord-015684-q10sx1dm	791	26	dementia	dementia	NN
cord-015684-q10sx1dm	791	27	Behavioral	behavioral	JJ
cord-015684-q10sx1dm	791	28	changes	change	NNS
cord-015684-q10sx1dm	791	29	associated	associate	VBN
cord-015684-q10sx1dm	791	30	with	with	IN
cord-015684-q10sx1dm	791	31	different	different	JJ
cord-015684-q10sx1dm	791	32	apolipoprotein	apolipoprotein	NN
cord-015684-q10sx1dm	791	33	E	e	NN
cord-015684-q10sx1dm	791	34	genotypes	genotype	NNS
cord-015684-q10sx1dm	791	35	in	in	IN
cord-015684-q10sx1dm	791	36	dementia	dementia	NN
cord-015684-q10sx1dm	791	37	Polymorphisms	polymorphism	NNS
cord-015684-q10sx1dm	791	38	in	in	IN
cord-015684-q10sx1dm	791	39	the	the	DT
cord-015684-q10sx1dm	791	40	angiotensin	angiotensin	NN
cord-015684-q10sx1dm	791	41	-	-	HYPH
cord-015684-q10sx1dm	791	42	converting	convert	VBG
cord-015684-q10sx1dm	791	43	enzyme	enzyme	NN
cord-015684-q10sx1dm	791	44	gene	gene	NN
cord-015684-q10sx1dm	791	45	are	be	VBP
cord-015684-q10sx1dm	791	46	associated	associate	VBN
cord-015684-q10sx1dm	791	47	with	with	IN
cord-015684-q10sx1dm	791	48	unipolar	unipolar	JJ
cord-015684-q10sx1dm	791	49	depression	depression	NN
cord-015684-q10sx1dm	791	50	,	,	,
cord-015684-q10sx1dm	791	51	ACE	ace	NN
cord-015684-q10sx1dm	791	52	activity	activity	NN
cord-015684-q10sx1dm	791	53	and	and	CC
cord-015684-q10sx1dm	791	54	hypercortisolism	hypercortisolism	NNP
cord-015684-q10sx1dm	791	55	Apolipoprotein	Apolipoprotein	NNP
cord-015684-q10sx1dm	791	56	E	e	NN
cord-015684-q10sx1dm	791	57	gene	gene	NN
cord-015684-q10sx1dm	791	58	polymorphism	polymorphism	NN
cord-015684-q10sx1dm	791	59	in	in	IN
cord-015684-q10sx1dm	791	60	early	early	JJ
cord-015684-q10sx1dm	791	61	and	and	CC
cord-015684-q10sx1dm	791	62	late	late	JJ
cord-015684-q10sx1dm	791	63	onset	onset	NN
cord-015684-q10sx1dm	791	64	bipolar	bipolar	JJ
cord-015684-q10sx1dm	791	65	patients	patient	NNS
cord-015684-q10sx1dm	791	66	Angiotensinrelated	Angiotensinrelated	NNP
cord-015684-q10sx1dm	791	67	genes	gene	NNS
cord-015684-q10sx1dm	791	68	in	in	IN
cord-015684-q10sx1dm	791	69	patients	patient	NNS
cord-015684-q10sx1dm	791	70	with	with	IN
cord-015684-q10sx1dm	791	71	panic	panic	NN
cord-015684-q10sx1dm	791	72	disorder	disorder	NN
cord-015684-q10sx1dm	791	73	Risk	risk	NN
cord-015684-q10sx1dm	791	74	factors	factor	NNS
cord-015684-q10sx1dm	791	75	for	for	IN
cord-015684-q10sx1dm	791	76	neuropsychiatric	neuropsychiatric	JJ
cord-015684-q10sx1dm	791	77	symptoms	symptom	NNS
cord-015684-q10sx1dm	791	78	in	in	IN
cord-015684-q10sx1dm	791	79	dementia	dementia	NN
cord-015684-q10sx1dm	791	80	:	:	:
cord-015684-q10sx1dm	791	81	the	the	DT
cord-015684-q10sx1dm	791	82	Cache	Cache	NNP
cord-015684-q10sx1dm	791	83	County	County	NNP
cord-015684-q10sx1dm	791	84	Study	Study	NNP
cord-015684-q10sx1dm	791	85	Apolipoprotein	Apolipoprotein	NNP
cord-015684-q10sx1dm	791	86	E	e	NN
cord-015684-q10sx1dm	791	87	genotype	genotype	NN
cord-015684-q10sx1dm	791	88	infl	infl	NN
cord-015684-q10sx1dm	791	89	uences	uence	NNS
cord-015684-q10sx1dm	791	90	presence	presence	NN
cord-015684-q10sx1dm	791	91	and	and	CC
cord-015684-q10sx1dm	791	92	severity	severity	NN
cord-015684-q10sx1dm	791	93	of	of	IN
cord-015684-q10sx1dm	791	94	delusions	delusion	NNS
cord-015684-q10sx1dm	791	95	and	and	CC
cord-015684-q10sx1dm	791	96	aggressive	aggressive	JJ
cord-015684-q10sx1dm	791	97	behavior	behavior	NN
cord-015684-q10sx1dm	791	98	in	in	IN
cord-015684-q10sx1dm	791	99	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	791	100	disease	disease	NN
cord-015684-q10sx1dm	791	101	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	791	102	genes	gene	NNS
cord-015684-q10sx1dm	791	103	and	and	CC
cord-015684-q10sx1dm	791	104	proteins	protein	NNS
cord-015684-q10sx1dm	791	105	,	,	,
cord-015684-q10sx1dm	791	106	and	and	CC
cord-015684-q10sx1dm	791	107	measures	measure	NNS
cord-015684-q10sx1dm	791	108	of	of	IN
cord-015684-q10sx1dm	791	109	cognition	cognition	NN
cord-015684-q10sx1dm	791	110	and	and	CC
cord-015684-q10sx1dm	791	111	depression	depression	NN
cord-015684-q10sx1dm	791	112	in	in	IN
cord-015684-q10sx1dm	791	113	older	old	JJR
cord-015684-q10sx1dm	791	114	men	man	NNS
cord-015684-q10sx1dm	791	115	Depression	depression	NN
cord-015684-q10sx1dm	791	116	in	in	IN
cord-015684-q10sx1dm	791	117	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	791	118	's	's	POS
cord-015684-q10sx1dm	791	119	disease	disease	NN
cord-015684-q10sx1dm	791	120	might	may	MD
cord-015684-q10sx1dm	791	121	be	be	VB
cord-015684-q10sx1dm	791	122	associated	associate	VBN
cord-015684-q10sx1dm	791	123	with	with	IN
cord-015684-q10sx1dm	791	124	apolipoprotein	apolipoprotein	NN
cord-015684-q10sx1dm	791	125	E	e	NN
cord-015684-q10sx1dm	791	126	epsilon	epsilon	NN
cord-015684-q10sx1dm	791	127	4	4	CD
cord-015684-q10sx1dm	791	128	allele	allele	NN
cord-015684-q10sx1dm	791	129	frequency	frequency	NN
cord-015684-q10sx1dm	791	130	in	in	IN
cord-015684-q10sx1dm	791	131	women	woman	NNS
cord-015684-q10sx1dm	791	132	but	but	CC
cord-015684-q10sx1dm	791	133	not	not	RB
cord-015684-q10sx1dm	791	134	in	in	IN
cord-015684-q10sx1dm	791	135	men	man	NNS
cord-015684-q10sx1dm	791	136	Four	four	CD
cord-015684-q10sx1dm	791	137	components	component	NNS
cord-015684-q10sx1dm	791	138	describe	describe	VBP
cord-015684-q10sx1dm	791	139	behavioral	behavioral	JJ
cord-015684-q10sx1dm	791	140	symptoms	symptom	NNS
cord-015684-q10sx1dm	791	141	in	in	IN
cord-015684-q10sx1dm	791	142	1,120	1,120	CD
cord-015684-q10sx1dm	791	143	individuals	individual	NNS
cord-015684-q10sx1dm	791	144	with	with	IN
cord-015684-q10sx1dm	791	145	late	late	JJ
cord-015684-q10sx1dm	791	146	-	-	HYPH
cord-015684-q10sx1dm	791	147	onset	onset	NN
cord-015684-q10sx1dm	791	148	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	791	149	's	's	POS
cord-015684-q10sx1dm	791	150	disease	disease	NN
cord-015684-q10sx1dm	791	151	Association	Association	NNP
cord-015684-q10sx1dm	791	152	analysis	analysis	NN
cord-015684-q10sx1dm	791	153	of	of	IN
cord-015684-q10sx1dm	791	154	apolipoprotein	apolipoprotein	NN
cord-015684-q10sx1dm	791	155	E	e	NN
cord-015684-q10sx1dm	791	156	genotype	genotype	NN
cord-015684-q10sx1dm	791	157	and	and	CC
cord-015684-q10sx1dm	791	158	risk	risk	NN
cord-015684-q10sx1dm	791	159	of	of	IN
cord-015684-q10sx1dm	791	160	depressive	depressive	JJ
cord-015684-q10sx1dm	791	161	symptoms	symptom	NNS
cord-015684-q10sx1dm	791	162	in	in	IN
cord-015684-q10sx1dm	791	163	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	791	164	's	's	POS
cord-015684-q10sx1dm	791	165	disease	disease	NN
cord-015684-q10sx1dm	791	166	Behavioural	behavioural	JJ
cord-015684-q10sx1dm	791	167	pathology	pathology	NN
cord-015684-q10sx1dm	791	168	in	in	IN
cord-015684-q10sx1dm	791	169	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	791	170	's	's	POS
cord-015684-q10sx1dm	791	171	disease	disease	NN
cord-015684-q10sx1dm	791	172	with	with	IN
cord-015684-q10sx1dm	791	173	special	special	JJ
cord-015684-q10sx1dm	791	174	reference	reference	NN
cord-015684-q10sx1dm	791	175	to	to	IN
cord-015684-q10sx1dm	791	176	apolipoprotein	apolipoprotein	NN
cord-015684-q10sx1dm	791	177	E	e	NN
cord-015684-q10sx1dm	791	178	genotype	genotype	NN
cord-015684-q10sx1dm	791	179	Apolipoprotein	Apolipoprotein	NNP
cord-015684-q10sx1dm	791	180	E	e	NN
cord-015684-q10sx1dm	791	181	genotype	genotype	NN
cord-015684-q10sx1dm	791	182	and	and	CC
cord-015684-q10sx1dm	791	183	major	major	JJ
cord-015684-q10sx1dm	791	184	depression	depression	NN
cord-015684-q10sx1dm	791	185	in	in	IN
cord-015684-q10sx1dm	791	186	a	a	DT
cord-015684-q10sx1dm	791	187	community	community	NN
cord-015684-q10sx1dm	791	188	of	of	IN
cord-015684-q10sx1dm	791	189	older	old	JJR
cord-015684-q10sx1dm	791	190	adults	adult	NNS
cord-015684-q10sx1dm	791	191	.	.	.
cord-015684-q10sx1dm	792	1	The	the	DT
cord-015684-q10sx1dm	792	2	Cache	Cache	NNP
cord-015684-q10sx1dm	792	3	County	County	NNP
cord-015684-q10sx1dm	792	4	Study	Study	NNP
cord-015684-q10sx1dm	792	5	Protective	protective	JJ
cord-015684-q10sx1dm	792	6	effect	effect	NN
cord-015684-q10sx1dm	792	7	of	of	IN
cord-015684-q10sx1dm	792	8	the	the	DT
cord-015684-q10sx1dm	792	9	Apoε2	Apoε2	NNP
cord-015684-q10sx1dm	792	10	allele	allele	NN
cord-015684-q10sx1dm	792	11	in	in	IN
cord-015684-q10sx1dm	792	12	major	major	JJ
cord-015684-q10sx1dm	792	13	depressive	depressive	JJ
cord-015684-q10sx1dm	792	14	disorder	disorder	NN
cord-015684-q10sx1dm	792	15	in	in	IN
cord-015684-q10sx1dm	792	16	Taiwanese	taiwanese	JJ
cord-015684-q10sx1dm	792	17	APOE	APOE	NNP
cord-015684-q10sx1dm	792	18	is	be	VBZ
cord-015684-q10sx1dm	792	19	associated	associate	VBN
cord-015684-q10sx1dm	792	20	with	with	IN
cord-015684-q10sx1dm	792	21	age	age	NN
cord-015684-q10sx1dm	792	22	-	-	HYPH
cord-015684-q10sx1dm	792	23	of	of	IN
cord-015684-q10sx1dm	792	24	-	-	HYPH
cord-015684-q10sx1dm	792	25	onset	onset	NN
cord-015684-q10sx1dm	792	26	,	,	,
cord-015684-q10sx1dm	792	27	but	but	CC
cord-015684-q10sx1dm	792	28	not	not	RB
cord-015684-q10sx1dm	792	29	cognitive	cognitive	JJ
cord-015684-q10sx1dm	792	30	functioning	functioning	NN
cord-015684-q10sx1dm	792	31	,	,	,
cord-015684-q10sx1dm	792	32	in	in	IN
cord-015684-q10sx1dm	792	33	late	late	JJ
cord-015684-q10sx1dm	792	34	-	-	HYPH
cord-015684-q10sx1dm	792	35	life	life	NN
cord-015684-q10sx1dm	792	36	depression	depression	NN
cord-015684-q10sx1dm	792	37	ApoE	ApoE	NNPS
cord-015684-q10sx1dm	792	38	isoforms	isoform	NNS
cord-015684-q10sx1dm	792	39	and	and	CC
cord-015684-q10sx1dm	792	40	measures	measure	NNS
cord-015684-q10sx1dm	792	41	of	of	IN
cord-015684-q10sx1dm	792	42	anxiety	anxiety	NN
cord-015684-q10sx1dm	792	43	in	in	IN
cord-015684-q10sx1dm	792	44	probable	probable	JJ
cord-015684-q10sx1dm	792	45	AD	ad	NN
cord-015684-q10sx1dm	792	46	patients	patient	NNS
cord-015684-q10sx1dm	792	47	and	and	CC
cord-015684-q10sx1dm	792	48	Apoe-/-mice	Apoe-/-mice	NFP
cord-015684-q10sx1dm	792	49	Differences	difference	NNS
cord-015684-q10sx1dm	792	50	in	in	IN
cord-015684-q10sx1dm	792	51	anxietyrelated	anxietyrelate	VBN
cord-015684-q10sx1dm	792	52	behaviour	behaviour	NN
cord-015684-q10sx1dm	792	53	between	between	IN
cord-015684-q10sx1dm	792	54	apolipoprotein	apolipoprotein	NN
cord-015684-q10sx1dm	792	55	E	E	NNP
cord-015684-q10sx1dm	792	56	-	-	HYPH
cord-015684-q10sx1dm	792	57	defi	defi	NNP
cord-015684-q10sx1dm	792	58	cient	cient	NNP
cord-015684-q10sx1dm	792	59	C57BL/6	C57BL/6	NNP
cord-015684-q10sx1dm	792	60	and	and	CC
cord-015684-q10sx1dm	792	61	wild	wild	JJ
cord-015684-q10sx1dm	792	62	type	type	NN
cord-015684-q10sx1dm	792	63	C57BL/6	C57BL/6	NNP
cord-015684-q10sx1dm	792	64	mice	mouse	NNS
cord-015684-q10sx1dm	792	65	Role	role	NN
cord-015684-q10sx1dm	792	66	of	of	IN
cord-015684-q10sx1dm	793	1	H3-receptor	H3-receptor	NNP
cord-015684-q10sx1dm	793	2	-	-	HYPH
cord-015684-q10sx1dm	793	3	mediated	mediate	VBN
cord-015684-q10sx1dm	793	4	signaling	signaling	NN
cord-015684-q10sx1dm	793	5	in	in	IN
cord-015684-q10sx1dm	793	6	anxiety	anxiety	NN
cord-015684-q10sx1dm	793	7	and	and	CC
cord-015684-q10sx1dm	793	8	cognition	cognition	NN
cord-015684-q10sx1dm	793	9	in	in	IN
cord-015684-q10sx1dm	793	10	wild	wild	JJ
cord-015684-q10sx1dm	793	11	-	-	HYPH
cord-015684-q10sx1dm	793	12	type	type	NN
cord-015684-q10sx1dm	793	13	and	and	CC
cord-015684-q10sx1dm	793	14	Apoe-/-mice	apoe-/-mice	NN
cord-015684-q10sx1dm	793	15	Relationship	relationship	NN
cord-015684-q10sx1dm	793	16	of	of	IN
cord-015684-q10sx1dm	793	17	deep	deep	JJ
cord-015684-q10sx1dm	793	18	white	white	JJ
cord-015684-q10sx1dm	793	19	matter	matter	NN
cord-015684-q10sx1dm	793	20	hyperintensities	hyperintensities	NNP
cord-015684-q10sx1dm	793	21	and	and	CC
cord-015684-q10sx1dm	793	22	apolipoprotein	apolipoprotein	NN
cord-015684-q10sx1dm	793	23	E	e	NN
cord-015684-q10sx1dm	793	24	genotype	genotype	NN
cord-015684-q10sx1dm	793	25	to	to	IN
cord-015684-q10sx1dm	793	26	depressive	depressive	JJ
cord-015684-q10sx1dm	793	27	symptoms	symptom	NNS
cord-015684-q10sx1dm	793	28	in	in	IN
cord-015684-q10sx1dm	793	29	older	old	JJR
cord-015684-q10sx1dm	793	30	adults	adult	NNS
cord-015684-q10sx1dm	793	31	without	without	IN
cord-015684-q10sx1dm	793	32	clinical	clinical	JJ
cord-015684-q10sx1dm	793	33	depression	depression	NN
cord-015684-q10sx1dm	793	34	Caudate	Caudate	NNP
cord-015684-q10sx1dm	793	35	nucleus	nucleus	NN
cord-015684-q10sx1dm	793	36	volumes	volume	NNS
cord-015684-q10sx1dm	793	37	and	and	CC
cord-015684-q10sx1dm	793	38	genetic	genetic	JJ
cord-015684-q10sx1dm	793	39	determinants	determinant	NNS
cord-015684-q10sx1dm	793	40	of	of	IN
cord-015684-q10sx1dm	793	41	homocysteine	homocysteine	JJ
cord-015684-q10sx1dm	793	42	metabolism	metabolism	NN
cord-015684-q10sx1dm	793	43	in	in	IN
cord-015684-q10sx1dm	793	44	the	the	DT
cord-015684-q10sx1dm	793	45	prediction	prediction	NN
cord-015684-q10sx1dm	793	46	of	of	IN
cord-015684-q10sx1dm	793	47	psychomotor	psychomotor	JJ
cord-015684-q10sx1dm	793	48	speed	speed	NN
cord-015684-q10sx1dm	793	49	in	in	IN
cord-015684-q10sx1dm	793	50	older	old	JJR
cord-015684-q10sx1dm	793	51	persons	person	NNS
cord-015684-q10sx1dm	793	52	with	with	IN
cord-015684-q10sx1dm	793	53	depression	depression	NN
cord-015684-q10sx1dm	793	54	A	a	DT
cord-015684-q10sx1dm	793	55	longitudinal	longitudinal	JJ
cord-015684-q10sx1dm	793	56	study	study	NN
cord-015684-q10sx1dm	793	57	of	of	IN
cord-015684-q10sx1dm	793	58	hippocampal	hippocampal	JJ
cord-015684-q10sx1dm	793	59	volume	volume	NN
cord-015684-q10sx1dm	793	60	,	,	,
cord-015684-q10sx1dm	793	61	cortisol	cortisol	NN
cord-015684-q10sx1dm	793	62	levels	level	NNS
cord-015684-q10sx1dm	793	63	,	,	,
cord-015684-q10sx1dm	793	64	and	and	CC
cord-015684-q10sx1dm	793	65	cognition	cognition	NN
cord-015684-q10sx1dm	793	66	in	in	IN
cord-015684-q10sx1dm	793	67	older	old	JJR
cord-015684-q10sx1dm	793	68	depressed	depressed	JJ
cord-015684-q10sx1dm	793	69	subjects	subject	NNS
cord-015684-q10sx1dm	794	1	Reduced	reduce	VBN
cord-015684-q10sx1dm	794	2	hippocapal	hippocapal	JJ
cord-015684-q10sx1dm	794	3	volumes	volume	NNS
cord-015684-q10sx1dm	794	4	and	and	CC
cord-015684-q10sx1dm	794	5	memory	memory	NN
cord-015684-q10sx1dm	794	6	loss	loss	NN
cord-015684-q10sx1dm	794	7	in	in	IN
cord-015684-q10sx1dm	794	8	patients	patient	NNS
cord-015684-q10sx1dm	794	9	with	with	IN
cord-015684-q10sx1dm	794	10	early	early	JJ
cord-015684-q10sx1dm	794	11	-	-	HYPH
cord-015684-q10sx1dm	794	12	and	and	CC
cord-015684-q10sx1dm	794	13	late	late	JJ
cord-015684-q10sx1dm	794	14	-	-	HYPH
cord-015684-q10sx1dm	794	15	onset	onset	NN
cord-015684-q10sx1dm	794	16	depression	depression	NN
cord-015684-q10sx1dm	794	17	Vascular	Vascular	NNP
cord-015684-q10sx1dm	794	18	/	/	SYM
cord-015684-q10sx1dm	794	19	risk	risk	NN
cord-015684-q10sx1dm	794	20	and	and	CC
cord-015684-q10sx1dm	794	21	late	late	JJ
cord-015684-q10sx1dm	794	22	-	-	HYPH
cord-015684-q10sx1dm	794	23	life	life	NN
cord-015684-q10sx1dm	794	24	depression	depression	NN
cord-015684-q10sx1dm	794	25	in	in	IN
cord-015684-q10sx1dm	794	26	a	a	DT
cord-015684-q10sx1dm	794	27	Korean	korean	JJ
cord-015684-q10sx1dm	794	28	community	community	NN
cord-015684-q10sx1dm	794	29	population	population	NN
cord-015684-q10sx1dm	794	30	Measuring	measure	VBG
cord-015684-q10sx1dm	794	31	the	the	DT
cord-015684-q10sx1dm	794	32	value	value	NN
cord-015684-q10sx1dm	794	33	of	of	IN
cord-015684-q10sx1dm	794	34	pharmacogenomics	pharmacogenomic	NNS
cord-015684-q10sx1dm	794	35	Assessing	assess	VBG
cord-015684-q10sx1dm	794	36	the	the	DT
cord-015684-q10sx1dm	794	37	cost	cost	NN
cord-015684-q10sx1dm	794	38	-	-	HYPH
cord-015684-q10sx1dm	794	39	effectiveness	effectiveness	NN
cord-015684-q10sx1dm	794	40	of	of	IN
cord-015684-q10sx1dm	794	41	pharmacogenomics	pharmacogenomic	NNS
cord-015684-q10sx1dm	794	42	Pharmacological	pharmacological	JJ
cord-015684-q10sx1dm	794	43	treatment	treatment	NN
cord-015684-q10sx1dm	794	44	of	of	IN
cord-015684-q10sx1dm	794	45	neuropsychiatric	neuropsychiatric	JJ
cord-015684-q10sx1dm	794	46	symptoms	symptom	NNS
cord-015684-q10sx1dm	794	47	of	of	IN
cord-015684-q10sx1dm	794	48	dementia	dementia	NN
cord-015684-q10sx1dm	794	49	.	.	.
cord-015684-q10sx1dm	795	1	A	a	DT
cord-015684-q10sx1dm	795	2	review	review	NN
cord-015684-q10sx1dm	795	3	of	of	IN
cord-015684-q10sx1dm	795	4	the	the	DT
cord-015684-q10sx1dm	795	5	evidence	evidence	NN
cord-015684-q10sx1dm	795	6	Memantine	Memantine	NNP
cord-015684-q10sx1dm	795	7	in	in	IN
cord-015684-q10sx1dm	795	8	moderate	moderate	JJ
cord-015684-q10sx1dm	795	9	-	-	HYPH
cord-015684-q10sx1dm	795	10	to	to	IN
cord-015684-q10sx1dm	795	11	-	-	HYPH
cord-015684-q10sx1dm	795	12	severe	severe	JJ
cord-015684-q10sx1dm	795	13	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	795	14	's	's	POS
cord-015684-q10sx1dm	795	15	disease	disease	NN
cord-015684-q10sx1dm	795	16	Donepezil	Donepezil	NNP
cord-015684-q10sx1dm	795	17	in	in	IN
cord-015684-q10sx1dm	795	18	patients	patient	NNS
cord-015684-q10sx1dm	795	19	with	with	IN
cord-015684-q10sx1dm	795	20	severe	severe	JJ
cord-015684-q10sx1dm	795	21	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	795	22	's	's	POS
cord-015684-q10sx1dm	795	23	disease	disease	NN
cord-015684-q10sx1dm	795	24	:	:	:
cord-015684-q10sx1dm	795	25	double	double	JJ
cord-015684-q10sx1dm	795	26	-	-	HYPH
cord-015684-q10sx1dm	795	27	blind	blind	JJ
cord-015684-q10sx1dm	795	28	,	,	,
cord-015684-q10sx1dm	795	29	parallel	parallel	JJ
cord-015684-q10sx1dm	795	30	-	-	HYPH
cord-015684-q10sx1dm	795	31	group	group	NN
cord-015684-q10sx1dm	795	32	,	,	,
cord-015684-q10sx1dm	795	33	placebo	placebo	NN
cord-015684-q10sx1dm	795	34	-	-	HYPH
cord-015684-q10sx1dm	795	35	controlled	control	VBN
cord-015684-q10sx1dm	795	36	study	study	NN
cord-015684-q10sx1dm	795	37	Donepezil	Donepezil	NNP
cord-015684-q10sx1dm	795	38	for	for	IN
cord-015684-q10sx1dm	795	39	severe	severe	JJ
cord-015684-q10sx1dm	795	40	Alzheimer	Alzheimer	NNP
cord-015684-q10sx1dm	795	41	's	's	POS
cord-015684-q10sx1dm	795	42	disease	disease	NN
cord-015684-q10sx1dm	795	43	Priorities	Priorities	NNPS
cord-015684-q10sx1dm	795	44	and	and	CC
cord-015684-q10sx1dm	795	45	standards	standard	NNS
cord-015684-q10sx1dm	795	46	in	in	IN
cord-015684-q10sx1dm	795	47	pharmacogenetic	pharmacogenetic	NNP
cord-015684-q10sx1dm	795	48	research	research	NN
cord-015684-q10sx1dm	795	49	Genomic	Genomic	NNP
cord-015684-q10sx1dm	795	50	screening	screening	NN
cord-015684-q10sx1dm	795	51	and	and	CC
cord-015684-q10sx1dm	795	52	replication	replication	NN
cord-015684-q10sx1dm	795	53	using	use	VBG
cord-015684-q10sx1dm	795	54	the	the	DT
cord-015684-q10sx1dm	795	55	same	same	JJ
cord-015684-q10sx1dm	795	56	data	datum	NNS
cord-015684-q10sx1dm	795	57	set	set	VBN
cord-015684-q10sx1dm	795	58	in	in	IN
cord-015684-q10sx1dm	795	59	familybased	familybased	NNP
cord-015684-q10sx1dm	795	60	association	association	NNP
cord-015684-q10sx1dm	795	61	testing	test	VBG
cord-015684-q10sx1dm	795	62	Pharm	Pharm	NNP
cord-015684-q10sx1dm	795	63	acogenomics	acogenomic	NNS
cord-015684-q10sx1dm	795	64	and	and	CC
cord-015684-q10sx1dm	795	65	individualized	individualized	JJ
cord-015684-q10sx1dm	795	66	drug	drug	NN
cord-015684-q10sx1dm	795	67	therapy	therapy	NN
cord-015684-q10sx1dm	795	68	Ethical	ethical	JJ
cord-015684-q10sx1dm	795	69	considerations	consideration	NNS
cord-015684-q10sx1dm	795	70	in	in	IN
cord-015684-q10sx1dm	795	71	the	the	DT
cord-015684-q10sx1dm	795	72	use	use	NN
cord-015684-q10sx1dm	795	73	of	of	IN
cord-015684-q10sx1dm	795	74	DNA	dna	NN
cord-015684-q10sx1dm	795	75	for	for	IN
cord-015684-q10sx1dm	795	76	the	the	DT
cord-015684-q10sx1dm	795	77	diagnosis	diagnosis	NN
cord-015684-q10sx1dm	795	78	of	of	IN
cord-015684-q10sx1dm	795	79	disease	disease	NN