id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-315193-z6v6s46n	Adhikari, Nilanjan	Structural Insight Into the Viral 3C-Like Protease Inhibitors: Comparative SAR/QSAR Approaches	2017-07-14		.txt	text/plain	9954	585	59	In the present report, quantitative structure-activity relationships (QSARs) techniques have been explored to understand the relation between the SARS-CoV 3CL pro and HRV 3C pro enzyme inhibitory activity with the physicochemical and structural properties of these inhibitors developed till now. (2008) reported some cinanserin analogs as SARS-CoV 3CL pro inhibitors (Table 11 .18), for which the QSAR model obtained was as shown by Eq. (2013b) reported a series of dipeptide-type SARS-CoV 3CL protease inhibitors (Table 11 .27) whose activity was shown to be controlled by the molar refractivity (CMR) and the polar volume (Pol Vol) of the compounds [Eq. QSAR models exhibited that the physicochemical parameters, such as dipole moment, PSA, polar volume, hydrophobicity, molar refractivity, SA, and molecular volume of the compounds play a crucial role in controlling both SARS-CoV 3CL pro and HRV 3C pro inhibitory activities.	./cache/cord-315193-z6v6s46n.txt	./txt/cord-315193-z6v6s46n.txt