id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-271032-imc6woht	Schulte-Schrepping, Jonas	Severe COVID-19 is marked by a dysregulated myeloid cell compartment	2020-08-05		.txt	text/plain	9740	692	58	Given the dramatic changes in various immune cell populations (Fig. 1C+D) , we next 171 assessed their composition and activation state by droplet-based scRNA-seq in 27 samples 172 from 18 COVID-19 patients (8 mild & 10 severe, cohort 1, Table S1 ) collected between day 173 3 and day 20 after symptom onset. All LDNs also expressed high levels of alarmins S100A8 and S100A9 (Fig. 5D) , whereas 343 other S100 genes (e.g. S100A4, S100A12) were strongly induced in selected neutrophil 344 Alterations of the neutrophil compartment were further interrogated by mass cytometry of 362 whole blood samples of COVID-19 patients (n=8 mild + 9 severe, cohort 1), FLI patients 363 (n=8), and age-and gender-matched controls (n=9) (Table S1), using a panel designed to 364 detect myeloid cell maturation and activation states as well as markers of 365 immunosuppression or dysfunction (Table S2) .	./cache/cord-271032-imc6woht.txt	./txt/cord-271032-imc6woht.txt