id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-280459-y0tbvs3t	Ramvikas, M.	Nasal Vaccine Delivery	2016-10-07		.txt	text/plain	7333	450	36	Yet developing vaccine delivery systems that induce humoral and cell-mediated response with mucosal immunity has been challenging to date. Nasal delivery of vaccines acts as a "first entry block," that is, blocks the pathogen entry, while invading to the mucosal surface by inducing local microbial-specific immune responses, thus increasing the general efficacy of the vaccine. The nasal route is considered an attractive route for vaccine administration with the following advantages: • Better patient compliance • Numerous microvilli present in the nasal epithelium provide a better absorption surface • Mucosal and systemic immune response can be induced • Easy immunization of large population groups • Nasal immunization does not require needles and syringes Many challenges stand in the way of developing nasal vaccines. Hence a polymer-based micro-/nanoparticulate system can be exploited as a viable nasal vaccine delivery system that is capable of delivering a multitude of antigens at the targeted sites and inducing desired immune response.	./cache/cord-280459-y0tbvs3t.txt	./txt/cord-280459-y0tbvs3t.txt