id author title date pages extension mime words sentences flesch summary cache txt cord-354743-mjaqt6wk Enard, David Viruses are a dominant driver of protein adaptation in mammals 2016-05-17 .txt text/plain 13687 708 54 Intriguingly, unlike for non-immune VIPs or all VIPs considered together (top of Figure 4B ), immune VIPs, including antiviral VIPs (Supplementary file 1D), do not show any increase of adaptation compared to immune non-VIPs. The lack of a signal is unlikely to be due to reduced statistical power of the comparison in a smaller set of immune proteins, given that 1000 random samples of non-immune VIPs with the same size as the immune VIPs sample (241) always exhibited a significantly (p<0.05) increased rate of adaptation compared to non-immune non-VIPs. The classic MK test is known to be biased downward by the presence of slightly deleterious non-synonymous variants (Charlesworth and Eyre-Walker, 2008b) and this bias is difficult to eliminate fully even by excluding low frequency variants (Messer and Petrov, 2013) . ./cache/cord-354743-mjaqt6wk.txt ./txt/cord-354743-mjaqt6wk.txt