id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-354003-ko45l1qv	Scarpin, M Regina	Parallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in translation	2020-10-15		.txt	text/plain	16822	829	46	Pioneering efforts to identify the mechanisms regulating translation of 5 0 TOP mRNAs, however, did show that wheat germ extracts contain a repressor that specifically limits translation of 5 0 TOP mRNAs in cell-free translation assays (Biberman and Meyuhas, 1999; Shama and Meyuhas, 1996) , suggesting that plants also discriminately regulate translation of 5 0 TOP mRNAs. Here, we show that the TOR-LARP1-5 0 TOP signaling axis regulates translation in Arabidopsis, impacting expression of a set of deeply conserved 5 0 TOP genes, including translation elongation factors, polyA-binding proteins, karyopherins/importins, and the translationally-controlled tumor protein. TOR-LARP1-5 0 TOP signaling in Arabidopsis seedlings regulates translation of mRNAs that encode deeply conserved eukaryotic proteins, plant lineage-specific proteins, and diverse proteins involved in ribosome biogenesis.	./cache/cord-354003-ko45l1qv.txt	./txt/cord-354003-ko45l1qv.txt