id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-342047-pm3i54mb	Du Preez, Andrea	The type of stress matters: repeated injection and permanent social isolation stress in male mice have a differential effect on anxiety- and depressive-like behaviours, and associated biological alterations	2020-09-21		.txt	text/plain	8828	419	38	Interestingly, combining the two distinct stress paradigms did not have an additive effect on behavioural and biological outcomes, but resulted in yet a different phenotype, characterized by increased anxiety-like behaviour, decreased plasma levels of IL1β, IL4 and VEGF, and decreased hippocampal neuronal differentiation, without altered neuroinflammation or corticosterone reactivity. Each treatment comprised one or two distinct stressors that was either in the form of repeated injection, which has been previously shown to differentially alter stress responses in BALB/C mice 20 and affective outcomes in outbred rats with high and low emotional reactivity 21 , or permanent social isolation, which has consistently been associated with depressivelike phenotypes 8, 9, 11 . Based on our data, we believe that the neurogenic profiles observed are a functional consequence of the neuroinflammatory changes associated with each stress exposure, given that microglia and astrocytes play an important role b Representative photomicrographs of the ventral (i) and dorsal (ii) dentate gyrus stained for Iba1 for repeatedly injected and socially isolated mice, respectively, all relative to controls.	./cache/cord-342047-pm3i54mb.txt	./txt/cord-342047-pm3i54mb.txt