id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-333145-a20dlaxn	Johnson, Todd A.	Association of an IGHV3-66 gene variant with Kawasaki disease	2020-10-26		.txt	text/plain	6438	303	49	In a meta-analysis of three GWAS for susceptibility to Kawasaki disease (KD) conducted in Japan, Korea, and Taiwan and follow-up studies with a total of 11,265 subjects (3428 cases and 7837 controls), a significantly associated SNV in the immunoglobulin heavy variable gene (IGHV) cluster in 14q33.32 was identified (rs4774175; OR = 1.20, P = 6.0 × 10(−9)). Considering that significant association of SNVs in the IGHV region with disease susceptibility was previously known only for rheumatic heart disease (RHD), a complication of acute rheumatic fever (ARF), these observations suggest that common B-cell related mechanisms may mediate the symptomology of KD and ARF as well as RHD. Instead, 7 out of 12 groups of SNVs in the 6p21 region examined in the Stage 2 analyses showed significant association in the metaanalyses of the data sets in the three GWAS as well as in the follow-up studies ( Table 1 and Supplementary Fig. 3A ).	./cache/cord-333145-a20dlaxn.txt	./txt/cord-333145-a20dlaxn.txt