id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-322129-uyswj4ow	Melin, Amanda D.	Comparative ACE2 variation and primate COVID-19 risk	2020-10-27		.txt	text/plain	6310	305	47	Infection studies of rhesus monkeys, long-tailed macaques, and vervets as biomedical models have made it clear that at least some nonhuman primate species are permissive to SARS-CoV-2 infection and develop symptoms in response to infection that resemble those of humans following the development of COVID-19, including similar age-related effects [11] [12] [13] [14] [15] [16] . We assessed the variation at amino acid residues identified as critical for ACE2 recognition by the SARS-CoV-2 RBD and undertook an analysis of positive selection and protein modeling to gauge the potential for adaptive differences and the likely effects of protein variation. In particular, the twelve sites in the ACE2 protein that are critical for binding of the SARS-CoV-2 virus are invariant across the Catarrhini, which includes great apes, gibbons, and monkeys of Africa and Asia (Fig. 1) .	./cache/cord-322129-uyswj4ow.txt	./txt/cord-322129-uyswj4ow.txt