id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-299605-j1ewxk4q	Lin, Jing-wen	Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria	2017-02-03		.txt	text/plain	6667	326	49	c. chabaudi, AS and CB, that differ in virulence in C57BL/6 mice, we performed high-resolution comparative whole-blood transcriptomic analysis throughout the acute phase of the blood-stage infection, and identified several transcriptomic signatures associated with severe malarial pathology before the onset of pathology or disease. Spearman's rank correlation coefficient (r s ) analysis of unfiltered transcripts normalised across the median of all samples, revealed high levels of similarity amongst naïve and 2, 4 dpi samples in both AS and CB infections (Fig. 2ai ,ii, r s ranging from 0.73 to 0.88), while from 6 dpi onwards the whole blood transcriptomes diverge significantly from the earlier time points (r s ranging from 0.08 to − 0.59 compared to naïve controls). Importantly, in 4 of the CB infected mice that had reached humane end points at 9 dpi, these 5 genes showed an even higher level of up-regulation compared to naïve controls (Fig. 3c) , indicating possible lung pathology in these 4 CB infected mice.	./cache/cord-299605-j1ewxk4q.txt	./txt/cord-299605-j1ewxk4q.txt