id author title date pages extension mime words sentences flesch summary cache txt cord-286217-3uklf2u2 Jiang, He-wei SARS-CoV-2 proteome microarray for global profiling of COVID-19 specific IgG and IgM responses 2020-07-14 .txt text/plain 6829 423 54 Here we construct a SARS-CoV-2 proteome microarray containing 18 out of the 28 predicted proteins and apply it to the characterization of the IgG and IgM antibodies responses in the sera from 29 convalescent patients. We detected the SARS-CoV-2-specific IgG and IgM proteins bound to the array using fluorescent-labeled anti-human antibodies, thereby generating a global assessment of each patient's humoral antibody response. All of the samples and the controls were probed on the proteome microarray, and after data filtering and normalization, we constructed the IgG and IgM profile for each serum and performed clustering analysis to generate heatmaps (Figs. To statistically analyze the IgG responses against SARS-CoV-2 proteins, we calculated the p-values followed by multiple testing correction (or q-values), and applied significant analysis of microarray (SAM) to identify significant positive proteins (Supplementary Fig. 7 and Data 2). ./cache/cord-286217-3uklf2u2.txt ./txt/cord-286217-3uklf2u2.txt