id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-282566-rgo5sj5i	Bernard, Sandra C	Pathogenic Neisseria meningitidis utilizes CD147 for vascular colonization	2014-06-01		.txt	text/plain	7474	374	40	However, β 2 -AR-depleted endothelial cells, although unable to promote signaling events, still support pilus-mediated bacterial adhesion, thus indicating that the primary meningococcal attachment requires another, yet unidentified, host receptor for type IV pili. Here, we report that CD147, a member of the immunoglobulin (Ig) superfamily, is a receptor for type IV pilus-mediated adhesion of pathogenic meningococci to human brain or peripheral endothelial cells through interaction with both major and minor pilins-PilE and PilV-and we establish the central role of CD147 for vascular colonization by meningococci in vivo. This study demonstrates that the specific interaction between the meningococcal ligands PilE and PilV and the cellular host receptor CD147 is essential for meningococcal adhesion to human endothelial cells and colonization of human blood vessels, a prerequisite to the major vascular alterations that are the hallmark of invasive meningococcal infections.	./cache/cord-282566-rgo5sj5i.txt	./txt/cord-282566-rgo5sj5i.txt