id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-004126-u6ts87ur	Furuyama, Wakako	A single dose of a vesicular stomatitis virus-based influenza vaccine confers rapid protection against H5 viruses from different clades	2020-01-10		.txt	text/plain	6034	333	51	Moreover, single vaccination induced cross-protective H5-specific antibodies and protected mice against lethal challenge with various H5 clade 2 viruses, highlighting the potential of the VSV-based HAfl as a pan-H5 influenza virus emergency vaccine. We found that a single vaccination with VSV-vectors expressing the full-length HA (HAfl) induced crossreactive H5-specific antibodies and conferred complete protection against lethal challenge with various H5 clade 2 viruses. In contrast to all the sHA-based vaccines, single doses of the VSV-EBOV-HAfl or VSV-HAfl vectors were sufficient to provide complete protection from lethal homologous H5N1 challenge in mice (Fig. 2) . However, this study did not provide any data supporting an advantage of including VSV-EBOV as part of the vector design over just expressing VSV-HAfl as both vectors performed similarly well with no statistically significant difference in efficacy following single-dose or prime/boost administration (Fig. 2 ) nor in antibody responses (Fig. 3, Table 1 ).	./cache/cord-004126-u6ts87ur.txt	./txt/cord-004126-u6ts87ur.txt