Summary of your 'study carrel' ============================== This is a summary of your Distant Reader 'study carrel'. The Distant Reader harvested & cached your content into a collection/corpus. It then applied sets of natural language processing and text mining against the collection. The results of this process was reduced to a database file -- a 'study carrel'. The study carrel can then be queried, thus bringing light specific characteristics for your collection. These characteristics can help you summarize the collection as well as enumerate things you might want to investigate more closely. This report is a terse narrative report, and when processing is complete you will be linked to a more complete narrative report. Eric Lease Morgan Number of items in the collection; 'How big is my corpus?' ---------------------------------------------------------- 449 Average length of all items measured in words; "More or less, how big is each item?" ------------------------------------------------------------------------------------ 32847 Average readability score of all items (0 = difficult; 100 = easy) ------------------------------------------------------------------ 47 Top 50 statistically significant keywords; "What is my collection about?" ------------------------------------------------------------------------- 434 study 161 patient 97 result 71 cell 65 method 54 University 52 COVID-19 51 group 51 Hospital 45 conclusion 40 dna 40 PCR 39 ICU 35 increase 35 high 30 disease 27 day 25 treatment 25 effect 25 case 24 SARS 23 year 23 level 23 RNA 22 HIV 21 child 21 Care 20 protein 20 MRI 19 IL-6 18 introduction 18 COPD 18 ARDS 17 expression 17 Health 17 Department 16 test 16 clinical 16 January 16 Institute 15 respiratory 15 mortality 15 asthma 15 Study 14 infection 14 activity 13 research 13 lung 13 covid-19 13 cancer Top 50 lemmatized nouns; "What is discussed?" --------------------------------------------- 107443 patient 99953 % 65502 study 47405 cell 38043 result 33664 group 27731 method 25401 case 24159 treatment 23389 level 23203 disease 23147 blood 21518 p 21276 year 21177 effect 20833 analysis 20651 time 20084 day 20080 protein 18959 datum 18785 conclusion 16317 age 16039 risk 15175 infection 15103 control 14435 factor 14253 rate 14152 expression 14093 activity 12872 system 12830 outcome 12596 child 12569 response 12245 therapy 12230 care 12151 use 11886 type 11781 gene 11725 sample 11474 difference 11358 test 11272 model 11213 change 10911 number 10742 hospital 10384 month 9957 diagnosis 9944 value 9853 function 9790 role Top 50 proper nouns; "What are the names of persons or places?" -------------------------------------------------------------- 8995 ICU 7675 al 7121 CT 6643 . 6456 et 6079 University 5649 mg 5541 C 4149 T 4025 II 4001 S. 3976 MRI 3873 Hospital 3761 PCR 3469 A 3103 CI 3009 B 2978 L 2955 RNA 2934 CF 2897 M. 2809 ± 2805 COVID-19 2779 M 2764 C. 2758 Health 2725 Department 2557 Japan 2535 kg 2412 AE 2291 MS 2288 E. 2142 ED 2136 Medical 2133 Group 2120 US 2116 HCV 2109 S 2107 J. 2097 D 2086 P. 2080 A. 2062 HIV 2002 Institute 1989 MR 1989 IV 1952 Background 1837 L. 1824 Study 1809 CFTR Top 50 personal pronouns nouns; "To whom are things referred?" ------------------------------------------------------------- 50698 we 23056 it 9375 they 4813 i 4394 them 2428 he 2044 she 1340 us 538 itself 536 you 512 one 385 themselves 153 me 101 him 76 her 51 himself 26 mg 24 ourselves 23 oneself 19 s 19 em 17 yourself 13 herself 12 myself 12 igg4 12 his 10 ours 9 mrs 9 iicas 8 iga1 8 ashcs 7 imagej 6 theirs 6 p210bcr 6 mrnas 6 's 5 cha 4 its 4 igfbp2 4 hmsh2 4 esat-6 3 tdcs 3 rrt 3 pbp 3 mutationtaster3 3 mine 3 interleukin-15 3 il- 3 igg1 3 i- Top 50 lemmatized verbs; "What do things do?" --------------------------------------------- 504601 be 80545 have 49893 use 26793 show 23061 include 21144 increase 19402 compare 17576 associate 17462 perform 15430 do 15361 find 14643 follow 13153 identify 12980 report 12975 base 12149 evaluate 11350 determine 11104 suggest 10550 reduce 10343 assess 10171 develop 9989 induce 9868 provide 9827 treat 9369 observe 9194 present 9167 measure 8955 relate 8440 investigate 8365 receive 8165 require 8138 obtain 7928 demonstrate 7843 study 7770 detect 7686 improve 7425 decrease 6963 consider 6892 indicate 6642 reveal 6633 lead 6549 cause 6536 involve 6524 occur 6513 undergo 6311 describe 6301 result 6269 remain 6223 make 5920 test Top 50 lemmatized adjectives and adverbs; "How are things described?" --------------------------------------------------------------------- 38795 not 34350 - 29486 high 20184 also 20159 clinical 18379 more 17478 low 16265 other 15395 well 14830 significant 13577 only 13249 different 12983 however 12812 most 11797 such 11661 significantly 11661 non 10904 positive 10670 first 9870 specific 9311 as 9138 acute 9000 human 8643 respectively 8628 normal 8593 early 8462 severe 8239 mean 8069 new 8049 important 7587 further 7292 respiratory 7232 old 7175 large 7100 common 7038 anti 6894 negative 6843 small 6610 primary 6607 long 6541 renal 6508 present 6334 medical 6156 total 5985 chronic 5915 single 5884 less 5835 similar 5793 several 5678 surgical Top 50 lemmatized superlative adjectives; "How are things described to the extreme?" ------------------------------------------------------------------------- 3047 most 1906 least 1792 good 1718 high 1404 Most 638 low 452 large 353 great 223 strong 212 common 165 late 153 bad 100 big 97 early 87 small 78 long 73 close 66 short 56 young 53 old 43 near 40 fast 31 safe 25 simple 22 new 21 poor 18 easy 17 weak 16 deep 13 p=0.016 11 -t 9 postt 8 wide 8 Least 7 slow 7 severe 7 clear 7 cfDNA 7 busy 7 broad 7 Panx1 6 rich 6 hot 5 steep 5 slight 5 sick 5 quick 5 narrow 5 fresh 5 -peptides Top 50 lemmatized superlative adverbs; "How do things do to the extreme?" ------------------------------------------------------------------------ 9765 most 1702 least 272 well 24 highest 9 fast 7 worst 7 lowest 5 long 4 shortest 4 s1p 4 erv1 3 youngest 3 hard 2 ® 2 strongest 2 panx1 2 cfdna 1 whereupon 1 themost 1 smallest 1 s2&3 1 micrometre 1 low(150 1 http://cira.med.yale.edu/ 1 greatest 1 freshest 1 fewest 1 farthest 1 ecommendatio.ns 1 early 1 cuituredonboneslicesbothin 1 cm² 1 astrocytomas 1 -v 1 -tug 1 -tion 1 -spectroscopic 1 -r 1 -8a 1 -0.2881 Top 50 Internet domains; "What Webbed places are alluded to in this corpus?" ---------------------------------------------------------------------------- 116 doi.org 19 osf.io 7 www.dovepress.com 7 orcid.org 6 creativecommons.org 6 creat 6 ccforum.com 6 aspredicted.org 5 www 5 bit.ly 4 www.mutationtaster.org 4 www.fns.usda.gov 3 www.nrlqa.net 3 www.mederrors.com. 3 www.mdpi.com 3 www.hsph.harvard.edu 3 www.frontiersin.org 3 www.clinicaltrialsregister.eu 2 www.who.int 2 www.ncbi.nlm.nih.gov 2 www.isrctn.com 2 www.drlinday.com 2 www.clinicaltrials.gov 2 sourceforge.net 2 respiratory-research.com 2 github.com 2 amstar.ca 2 abcis.cbs.cnrs.fr 1 zha 1 zenodo.org 1 www.xml.org 1 www.wunderground.com 1 www.wcfs.nl 1 www.w3.org 1 www.unhchr.ch 1 www.ukev.org.uk 1 www.uis.unesco.org 1 www.thingiverse 1 www.surveymonkey.com 1 www.stratcomcoe.org 1 www.shef.ac.uk 1 www.scfbio- 1 www.rsna.org 1 www.rna.it-chiba.ac.jp 1 www.redorbit.com 1 www.real-score.org 1 www.rcsb.org 1 www.randomizer.org 1 www.radlist.uni-erlangen.de 1 www.prolific.co Top 50 URLs; "What is hyperlinked from this corpus?" ---------------------------------------------------- 17 http://doi.org/10.1101/2020.07.03.20145607 11 http://doi.org/10 8 http://doi.org/10.1101/2020.08.27.20183012 7 http://doi.org/10.1101/2020.08.11.20168773 7 http://doi.org/10.1101/2020.05.02.20088872 6 http://doi.org/10.1101/2020.05.19.20106997 6 http://creat 6 http://ccforum.com/supplements/17/S2 5 http://www 5 http://creativecommons.org/licenses/by/4.0/ 4 http://www.mutationtaster.org 4 http://doi.org/10.1101/2020.09.22.20199455 4 http://doi.org/10.1101/2020.06.09.20125690 4 http://doi.org/10.1101/2020.05.19.20106906 4 http://doi.org/10.1101/2020.01 3 http://www.nrlqa.net 3 http://www.mederrors.com. 3 http://www.hsph.harvard.edu/cearegistry 3 http://www.dovepress.com/ 3 http://osf.io/7zspe/?view_only=6bb956754be44977bdadfc07dd038602 3 http://osf.io/7d3xh/ 3 http://doi.org/10.1101/2020.01.13.20017228 2 http://www.fns.usda.gov/wic/anprmcomments/ 2 http://www.fns.usda.gov/fsp/faqs.htm#9 2 http://www.drlinday.com 2 http://www.clinicaltrials.gov 2 http://osf.io/96de2/ 2 http://doi.org/10.1101/2020.05.18.20104802 2 http://doi.org/10.1101/2020.05 2 http://doi.org/10.1101/2020.03 2 http://doi.org/10.1038/s41598-020-74555-2 2 http://aspredicted.org/blind.php?x=yb65fg 2 http://aspredicted.org/blind.php?x=7re3ze 2 http://amstar.ca/Amstar_Checklist.php 1 http://zha 1 http://zenodo.org/ 1 http://www.xml.org 1 http://www.wunderground.com 1 http://www.who.int/medicines/access/controlled-substances/ 1 http://www.who.int/ 1 http://www.wcfs.nl/ 1 http://www.w3.org/TR/SOAP 1 http://www.unhchr.ch/html/menu3/b/h_cat39.htm 1 http://www.ukev.org.uk/public-engagementmaterials/ 1 http://www.uis.unesco.org/template/ 1 http://www.thingiverse 1 http://www.surveymonkey.com 1 http://www.stratcomcoe.org/news-hero 1 http://www.shef.ac.uk/FRAX 1 http://www.scfbio- Top 50 email addresses; "Who are you gonna call?" ------------------------------------------------- 4 snarayan@childrensnational.org 4 dvolpe@sirm.org 3 ubakir@metu.edu.tr 3 nkadom@childrensnational.org 3 lnatale@rm.unicatt.it 3 drvikasmenghani@gmail.com 3 dristuna@yahoo.com 2 ziyadlk@hotmail.com 2 yseimen@phys.uoa.gr 2 yacine001@yahoo.fr 2 uxraul@ous-hf.no 2 usha.nagaraj@osumc.edu 2 turupoli@freemail.hu 2 tonikus@libero.it 2 thomas.knogler@meduniwien.ac.at 2 tamaki-i@mars.sannet.ne.jp 2 t.vogl@em.uni-frankfurt.de 2 suri@uthscsa.edu 2 suraj.serai@cchmc.org 2 sanjeevnayak@hotmail.com 2 roland@talanow.info 2 red-rad@ath.forthnet.gr 2 ragsne@med-rz.uni-sb.de 2 quaia@units.it 2 pcalik@metu.edu.tr 2 paolantoniopasquale@hotmail.com 2 ozdamar@eng.ankara.edu.tr 2 ovidstudie@usz.ch 2 oussamajaoued@gmail.com 2 opiany@gmail.com 2 mnq@biocentrum.dtu.dk 2 mjl1213@yumc.yonsei.ac.kr 2 marco.rengo@gmail.com 2 m.j.w.greuter@umcg.nl 2 lzarudzki@op.pl 2 kurianj@email.chop.edu 2 kim.cecil@cchmc.org 2 jonathan.portelli@um.edu.mt 2 jibilbao@unav.es 2 jianying.li@med.ge.com 2 jaraque@georgiahealth.edu 2 ishifuro@hiroshima-u.ac.jp 2 fracarb@gmail.com 2 federica.pediconi@uniroma1.it 2 esipov@ibch.ru 2 eiblanco74@gmail.com 2 e.nhihuynh@gmail.com 2 dpetrides@intelligen.com 2 dkilic@yildiz.edu.tr 2 dchourm@hol.gr Top 50 positive assertions; "What sentences are in the shape of noun-verb-noun?" ------------------------------------------------------------------------------- 173 levels were significantly 143 patients did not 116 % were male 86 study did not 83 levels were higher 83 patients were male 82 data are available 77 studies did not 76 patients were not 73 % were female 69 studies are necessary 67 patients were randomly 61 levels were not 59 effect was not 56 groups were similar 56 patients do not 52 group was significantly 50 patient did not 48 expression was significantly 48 patients were more 47 % did not 46 data were available 45 analysis did not 43 cells were then 42 cells were positive 42 group were significantly 41 patients were also 41 treatment did not 40 expression was not 40 groups did not 40 patients had normal 40 patients were female 39 cells did not 39 results are consistent 38 groups were comparable 38 levels were also 38 results were not 37 study does not 36 data was available 35 patients had positive 34 group did not 34 levels did not 34 patients had at 34 patients is not 34 patients were eligible 34 patients were prospectively 34 results were similar 34 studies have not 33 level was significantly 33 patients had higher Top 50 negative assertions; "What sentences are in the shape of noun-verb-no|not-noun?" --------------------------------------------------------------------------------------- 13 groups was not statistically 11 levels were not significantly 11 results were not statistically 10 data were not available 9 analysis showed no significant 8 expression was not significantly 8 patient had no further 8 patients is not well 8 treatment had no effect 7 effect was not significant 7 groups was not significant 7 levels were not different 7 patient had no errors 7 studies have not conclusively 7 treatment did not significantly 6 groups was not significantly 6 groups were not statistically 6 patient had no history 6 rate was not different 5 group was not significant 5 groups showed no significant 5 groups were not significant 5 groups were not significantly 5 patients had no significant 5 studies did not substantially 5 study showed no significant 4 analysis showed no difference 4 cells are not available 4 effect was not specific 4 groups did not significantly 4 patients is not clear 4 rates were not statistically 4 results have not yet 3 % had no effect 3 activity was not enough 3 blood was not less 3 cell was not present 3 cells are not only 3 cells do not consistently 3 cells showed no change 3 data are not available 3 effect was not significantly 3 group was not statistically 3 group were not significantly 3 groups has not statistical 3 levels are not relevant 3 levels showed no differences 3 levels were not statistically 3 methods are not sufficiently 3 patient had no significant A rudimentary bibliography -------------------------- id = cord-330994-6nu7utu1 author = Abdelrheem, Doaa A. title = The inhibitory effect of some natural bioactive compounds against SARS-CoV-2 main protease: insights from molecular docking analysis and molecular dynamic simulation date = 2020-10-01 keywords = 3TNT; SARS; compound; study summary = title: The inhibitory effect of some natural bioactive compounds against SARS-CoV-2 main protease: insights from molecular docking analysis and molecular dynamic simulation This work aimed at evaluating the inhibitory effect of ten natural bioactive compounds (1–10) as potential inhibitors of SARS-CoV-2-3CL main protease (PDB ID: 6LU7) and SARS-CoV main proteases (PDB IDs: 2GTB and 3TNT) by molecular docking analysis. [6] So, we study the inhibitory effect of some bioactive compounds obtained from natural sources against SARS-CoV-2-3CLpro and SARS-CoV main proteases (PDB IDs: 2GTB and 3TNT). The crystal structures of SARS-CoV-2-3CLpro (PDB code: 6LU7) and main proteases of SARS-Coronavirus (Mpro) with (PDB IDs: 2GTB and 3TNT) were downloaded from the Protein Data Bank (www.pdb.org), and any heteroatoms and water molecules were removed before molecular docking studies. Based on our molecular docking analysis we found that among all studied compounds, caulerpin has the highest binding affinity against all studied receptors 6LU7, 3TNT, and 2GTB with compared to some proposed antiviral drug currently used in COVID-19 treatment. doi = 10.1080/10934529.2020.1826192 id = cord-262164-cxs5xgvv author = Ackerman, Joshua M. title = What people believe about detecting infectious disease using the senses date = 2020-10-19 keywords = belief; sense; sensory; study summary = Because existing evidence for detection does not support this ability-perceivers using auditory cues were no better than chance when attempting to identify whether coughs and sneezes were infectious in origin )-this belief could lead people to engage in social interactions that increase their risk of infection or to needlessly avoid others who pose no disease threat. Here, we investigated lay beliefs about the perceived effectiveness and likelihood of use for the five major senses when identifying dangers associated with the pathogenic reservoirs of people (Study 1) and food (Study 2). Sensory information involving sight and sound can be encoded at greater physical distances, and thus their use presents less risk of pathogen transmission relative to taste, touch, and smell (senses effective at greater distances also allow earlier identification, and perhaps avoidance, of infected targets). As in earlier studies, participants in the pathogen threat conditions rated the senses on their effectiveness and likelihood of use for determining whether another person or a food was an infection risk. doi = 10.1016/j.cresp.2020.100002 id = cord-286565-bmcsyfz9 author = Akdeniz, Gulsum title = A Survey of Attitudes, Anxiety Status, and Protective Behaviors of the University Students During the COVID-19 Outbreak in Turkey date = 2020-07-15 keywords = COVID-19; outbreak; study summary = This study aims to assess the spread and frequency of protective behaviors, emotional and anxiety status among the Turkish population using a rapid survey during the COVID-19 outbreak. Respondents were asked about about (i) demographic and epidemiological information, (ii) protective behaviors to prevent catching the coronavirus, (iii) different emotions and thoughts caused by the COVID-19 outbreak, (iv) anxiety status during the COVID-19 outbreak, and (v) exposure to COVID-19 Outbreak on TV. So, the current study aimed to determine the prevalence and distribution of anxiety and emotional status and protective behaviors among the young Turkish population and examine their associations with media exposure using a rapid assessment during the COVID-19 outbreak. So, the current study aimed to determine the prevalence and distribution of anxiety and emotional status and protective behaviors among the young Turkish population and examine their associations with media exposure using a rapid assessment during the COVID-19 outbreak. doi = 10.3389/fpsyt.2020.00695 id = cord-257073-dm80bxnd author = Akmatov, Manas K. title = E-mail-based symptomatic surveillance combined with self-collection of nasal swabs: a new tool for acute respiratory infection epidemiology date = 2011-08-17 keywords = respiratory; study; swab summary = OBJECTIVE: We examined the feasibility of combining communication by e-mail and self-collection of nasal swabs for the prospective detection of acute respiratory infections in a non-medical setting. Conclusions: Combining e-mail-based symptomatic surveillance with nasal self-swabbing promises to be a powerful tool for the real-time identification of incident cases of acute respiratory infections and the associated pathogens in population-based studies. Conclusions: Combining e-mail-based symptomatic surveillance with nasal self-swabbing promises to be a powerful tool for the real-time identification of incident cases of acute respiratory infections and the associated pathogens in population-based studies. We tested the feasibility of combining real-time symptomatic surveillance with nasal self-swabbing for the prospective collection of epidemiologic and virological data on acute respiratory infections. Combining e-mail-based active symptomatic surveillance with self-collection of nasal swabs ensured prospective, accurate collection of data on incident episodes of acute respiratory infections and timely sample collection for the detection of respiratory pathogens. doi = 10.1016/j.ijid.2011.07.005 id = cord-345108-gtp36snr author = Al-Ani, Raid M. title = Prevalence of Anosmia and Ageusia in Patients with COVID-19 at a Primary Health Center, Doha, Qatar date = 2020-08-19 keywords = COVID-19; STA; study summary = The male sex, history of recent travel, smoking, and severe course of the disease were positive, highly significant association with anosmia or ageusia. Data regarding the age, gender, history of recent travel, presenting symptoms (fever, myalgia, cough, dyspnea, fatigability, sore throat, anosmia, ageusia, diarrhea, etc.), past nasal and paranasal diseases (NPND), history of smoking, and the severity of the disease were taken from every patient who tested positive. There was a positively statistically significant difference between the 2 groups of patients (with and without anosmia) regarding the following factors the male sex, history of recent travel, smokers, and severe course of the disease. There was a positively statistically significant difference between the 2 groups of patients (with and without ageusia) regarding the following factors the male sex, history of recent travel, smokers, past history of NPND, and severe course of the disease. doi = 10.1007/s12070-020-02064-9 id = cord-347207-1u4i6qmc author = Almomani, Huda Y. title = Randomised controlled trial of pharmacist-led patient counselling in controlling hypoglycaemic attacks in older adults with type 2 diabetes mellitus (rose-adam): A study protocol date = 2020-07-29 keywords = diabetes; intervention; study; type summary = title: Randomised controlled trial of pharmacist-led patient counselling in controlling hypoglycaemic attacks in older adults with type 2 diabetes mellitus (rose-adam): A study protocol Several studies have established the important positive role of educational interventions on achieving glycaemic control and other clinical outcomes, however, there is still a lack in studies that evaluate the impact of such type of interventions on hypoglycaemia risk in elderly patients with type 2 diabetes. The purpose of this research is to evaluate the effectiveness of pharmacist-led patient counselling on reducing hypoglycaemic attacks in older adults with type 2 diabetes mellitus. Participants who are elderly (age ≥ 65 years), diagnosed with type 2 diabetes mellitus, and taking insulin, sulfonylurea, or any three anti-diabetic medications will be randomly assigned to intervention (SUGAR Handshake) and control (usual care) groups. doi = 10.1016/j.sapharm.2020.07.012 id = cord-316746-toen5nvr author = Alves, F. title = Canine parvovirus: a predicting canine model for sepsis date = 2020-06-15 keywords = PIRO; SIRS; dog; study summary = The possibility of stratifying and classifying septic dogs was assessed using a proposed animal adapted PIRO (Predisposition, Infection, Response and Organ dysfunction) scoring system. RESULTS: The 72 dogs enrolled in this study were scored for each of the PIRO elements, except for Infection, as all were considered to have the same infection score, and subjected to two sets of SIRS criteria, in order to measure their correlation with the outcome. The main objective of the current study was to assess the prognostic value of the presenting vital signs as well as to evaluate the possibility of stratifying and classifying septic animals according to a proposed PIRO classification system, using parvovirus infection as a natural model for sepsis study [10] . Table 1 gathers all leucocyte counts, a selection of clinical examination parameters (Temperature, Heart Rate and Respiratory Rate), all individual variables of PIRO (P=Predisposition, I=Infection, R = Response, O=Organ Dysfunction), the total PIRO score and both SIRS criteria for survivors and non-survivors dogs. doi = 10.1186/s12917-020-02417-0 id = cord-264133-yj100ryt author = Anderson, Gregory S. title = Peer Support and Crisis-Focused Psychological Interventions Designed to Mitigate Post-Traumatic Stress Injuries among Public Safety and Frontline Healthcare Personnel: A Systematic Review date = 2020-10-20 keywords = FHP; PPTE; PSP; study summary = Thematic groups identified within the literature included CISD (n = 5: included 2 studies with undefined organizationally-offered or -facilitated debriefing) and critical incident stress management (CISM, n = 1), as well as several peer support programs (n = 8) including types of psychological or mental health first aid and trauma risk management. Thematic groups identified within the literature included CISD (n = 5: included 2 studies with undefined organizationally-offered or -facilitated debriefing) and critical incident stress management (CISM, n = 1), as well as several peer support programs (n = 8) including types of psychological or mental health first aid and trauma risk management. The current review identified 14 studies measuring the effectiveness of peer support programs and crisis-focused psychological interventions among PSP and FHP following exposure to a PPTE with the hopes of mitigating PTSIs, and ultimately PTSD. doi = 10.3390/ijerph17207645 id = cord-287367-1sdt9zz8 author = Andrews, Denise title = Multiplex PCR point of care testing versus routine, laboratory-based testing in the treatment of adults with respiratory tract infections: a quasi-randomised study assessing impact on length of stay and antimicrobial use date = 2017-10-10 keywords = POC; arm; patient; study summary = title: Multiplex PCR point of care testing versus routine, laboratory-based testing in the treatment of adults with respiratory tract infections: a quasi-randomised study assessing impact on length of stay and antimicrobial use Consequently, though respiratory viruses are frequently isolated in community acquired pneumonia (CAP) [2] and are reported to be responsible for 12.8% of CAP cases admitted to UK hospitals [3] , the decision to manage as a viral RTI or treat for bacterial infection including Mycoplasma pneumoniae or Chlamydia pneumoniae (''atypical bacteria'') is based upon the clinical scenario and severity criteria such as the CURB-65 score. We undertook a study to assess the FilmArray® RP panel as a POC test compared to routine, laboratory-based detection methods in order to assess the impact on length of stay and antibiotic utilization. The aim of the study was to determine whether in adults presenting with upper respiratory tract infection (URTI)/ influenza-like illness (ILI) +/− lower respiratory tract infection (LRTI), FilmArray® RP panel POC testing, when compared to the routine, laboratory-based RP testing was associated with length of hospital stay or antimicrobial use. doi = 10.1186/s12879-017-2784-z id = cord-301143-o12we0uw author = Andualem, Atsedemariam title = Adherence to Lifestyle Modifications and Associated Factors Among Adult Hypertensive Patients Attending Chronic Follow-Up Units of Dessie Referral Hospital, North East Ethiopia, 2020 date = 2020-10-23 keywords = adherence; lifestyle; modification; study summary = title: Adherence to Lifestyle Modifications and Associated Factors Among Adult Hypertensive Patients Attending Chronic Follow-Up Units of Dessie Referral Hospital, North East Ethiopia, 2020 Adherence to recommended lifestyle modification can be affected by demographic factors; patients'' level of monthly income, educational level, age, co-morbidity, knowledge about the disease, self-efficacy, social support, smoking, obesity, harmful use of alcohol and sedentary lifestyle, continuity of health education and counseling as well as motivation. Therefore this study aimed to assess adherence to lifestyle modifications and associated factors among hypertensive patients attending chronic follow-up units of Dessie referral hospital. This study aimed to investigate adherence to recommended lifestyle modifications and associated factors among hypertensive patients attending chronic follow-up units of Dessie referral hospital, North East Ethiopia. Adherence to recommended lifestyle modifications and factors associated for hypertensive patients attending chronic follow-up units of selected public hospitals in Addis Ababa doi = 10.2147/ibpc.s275575 id = cord-013830-qfvceu65 author = Ang, Juan Lyn title = A systematic review of real-world evidence of the management of macular oedema secondary to branch retinal vein occlusion date = 2020-04-20 keywords = BRVO; retinal; study; treatment summary = doi = 10.1038/s41433-020-0861-9 id = cord-352844-wggg3ynb author = Annunziata, Francesca title = An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities date = 2020-06-29 keywords = Candida; IC50; MIC; Pechmann; Synthesis; XII; activity; cell; compound; coumarin; derivative; figure; scheme; study summary = Again, the coumarin derivative showed inhibitory activity on 15-LOX-1 in PC3 and DU145 cell lines, thus inducing apoptosis of the cancer cell, with the same mechanism of The results represent a good starting point for the design of novel derivatives, because most of the examined compounds exhibited selective toxicity on HeLa cells (IC 50 values between 136.4 ± 1.90 µM and 172.2 ± 1.80 µM after 24 h), whereas no negative effects on HDF normal cell''s growth was detected. Since tacrine is a well-known inhibitor of the catalytic site of AChE, whereas coumarins showed affinity for the peripheral anionic site (PAS) [161] , this new compounds may be potential dual-and therefore more powerful -inhibitors of ChEs. The in vitro AChE and BuChE inhibitory activity was evaluated using the Ellman''s method [159] ; among all the tested molecules, compound 105 resulted the best in AChE inhibition (IC 50 Thanks to their simple structural architecture and chemical stability, coumarins can be easily synthesized and modified in order to produce more active and selective compounds. doi = 10.3390/ijms21134618 id = cord-005569-9d51l6bn author = Antonelli, Massimo title = Year in review in Intensive Care Medicine, 2008: I. Brain injury and neurology, renal failure and endocrinology, metabolism and nutrition, sepsis, infections and pneumonia date = 2008-12-09 keywords = ICP; ICU; NTM; TBI; VAP; patient; sepsis; study summary = doi = 10.1007/s00134-008-1371-6 id = cord-005750-54hul2lw author = Antonelli, Massimo title = Year in review in Intensive Care Medicine, 2008: III. Paediatrics, Ethics, outcome research and critical care organization, sedation, pharmacology and miscellanea date = 2009-02-10 keywords = ICU; care; child; patient; study summary = doi = 10.1007/s00134-009-1433-4 id = cord-012115-hpsxi9ay author = Archie, Patrick title = Music-based interventions in palliative cancer care: a review of quantitative studies and neurobiological literature date = 2013-05-30 keywords = anxiety; cancer; music; patient; study summary = doi = 10.1007/s00520-013-1841-4 id = cord-251962-xeue441p author = Armour, Cherie title = The COVID-19 Psychological Wellbeing Study: Understanding the Longitudinal Psychosocial Impact of the COVID-19 Pandemic in the UK; a Methodological Overview Paper date = 2020-11-04 keywords = COVID-19; Health; Psychological; Study; Wellbeing summary = The aim of this paper was to describe (1) the rationale behind the study and the corresponding selection of constructs to be assessed; (2) the study design and methodology; (3) the resultant sociodemographic characteristics of the full sample; (4) how the baseline survey data compares to the UK adult population (using data from the Census) on a variety of sociodemographic variables; (5) the ongoing efforts for weekly and monthly longitudinal assessments of the baseline cohort; and (6) outline future research directions. 2005) , posttraumatic stress symptoms were measured, and, given the nature of the study and prior research having highlighted that quarantined and infected individuals and their family 1 Please note that these figures refer to deaths of people who had a confirmed positive COVID19 test result. In order to assess the representativeness of the COVID-19 Psychological Wellbeing Study sample to the UK general population, it was compared to data from the UK Census 2011 for adults aged 18 years + . doi = 10.1007/s10862-020-09841-4 id = cord-017208-7oew461e author = Aurigemma, Rosemarie title = Regulatory Aspects in the Development of Gene Therapies date = 2005 keywords = FDA; animal; cell; dna; gene; product; safety; study; vector summary = Table 1 Beyond a Good Idea: What the Successful Investigator Has Already Done With a Project Leading to Commercial Development Defined candidate biologic (or molecule) Made comparisons with similar products Characteristics of product are consistent with pharmaceutical requirements Production scale is adequate Product characterization is adequate Laboratory reference standard exists In vitro potency assay has been developed Stability studies develop confidence product is a "drug" Reproducible model systems have confirmed in vivo activity with clinical product Early animal work includes some toxicology Scale-up requirements practical for initial clinical trials In general, reflects experience and scientific maturity of investigator In addition to the US agencies that develop the regulations that govern drug development and licensing, the International Conference on Harmonization (ICH) was formed in April 1990 involving the United States, the European Union, and Japan to address the issue of globalizing such regulations. doi = 10.1007/978-1-59259-785-7_29 id = cord-333801-4pjdutgg author = Awaisu, Ahmed title = Research Designs and Methodologies Related to Pharmacy Practice date = 2019-12-31 keywords = design; pharmacy; practice; research; study summary = Various study designs, including, but not limited to experimental, quasi-experimental, observational, qualitative, and mixed method designs, have been used in pharmacy practice research. The choice of a study design to answer a research question in pharmacy practice research is driven by several factors, including the type of the research question or the research hypothesis, expertise of the investigator, availability of data, and funding opportunities. Traditionally, core quantitative approaches used in pharmacy practice research include nonexperiments, quasi-experimental designs, and true experimental designs such as prospective randomized controlled intervention trials. In pharmacoepidemiology and other areas of pharmacy practice, researchers are often interested in measuring the relationships between exposure to a drug and its efficacy, toxicity, or other outcomes of interest using observational study designs. In the following section, interpretative frameworks and philosophical orientations, methodologies, data collection and analysis methods, approaches to ensure rigor, and ethical considerations in qualitative research are briefly discussed (Cohen et al., 2013; Creswell, 2013) . doi = 10.1016/b978-0-12-812735-3.00602-6 id = cord-268149-narre5e7 author = Aziz, Muhammad Abdul title = Traditional uses of medicinal plants used by Indigenous communities for veterinary practices at Bajaur Agency, Pakistan date = 2018-01-29 keywords = Pakistan; ethnoveterinary; indigenous; medicinal; plant; study summary = title: Traditional uses of medicinal plants used by Indigenous communities for veterinary practices at Bajaur Agency, Pakistan Most widely used medicinal plants with maximum use reports (URs) were Visnaga daucoides Gaertn., Foeniculum vulgare Mill., Solanum virginianum L., Withania somnifera (L.) Dunal, Glycyrrhiza glabra L., and Curcuma longa L. It has been recognized that plants have the capacity to combat several types of diseases ethnoveterinary medicines, a term generally used for folk skills, beliefs, knowledge, practices, methods related to animals'' health, and cure of various ailments in the rural areas [1] . Indigenous people of the study area are rich in traditional knowledge on veterinary medicines, which may be due to their close observation on domestic animals being considered as an important part of traditional lifestyle. Medicinal plants with high URs strengthen the concept that such species are more significant to the local population and useful in sharing the traditional knowledge with one another in the area. doi = 10.1186/s13002-018-0212-0 id = cord-338730-49ai51ah author = Baashar, Yahia title = Customer relationship management systems (CRMS) in the healthcare environment: A systematic literature review date = 2020-08-31 keywords = CRM; CRMS; healthcare; study summary = Analysis and evaluation of 19 carefully selected studies revealed three main research categories: (i) social CRM ''eCRM''; (ii) implementing CRMS; and (iii) adopting CRMS; with positive outcomes for CRM both in terms of patients relationship/communication with hospital, satisfaction, medical treatment/outcomes and empowerment and hospitals medical operation, productivity, cost, performance, efficiency and service quality. Studies were eligible for inclusion if they were: presenting an empirical and conceptual evidence; directly relevant to CRM in healthcare settings (hospitals, clinics and medical centres); papers that are conducted in developing countries; published from 2000 to present; and published in peer-reviewed journals. To synthesise the data as accurately and in an unbiased manner as possible, we performed a narrative synthesis review for effectiveness [65] of diverse study characteristics, which allowed us to categorise and identify three main CRM research categories that were relevant to healthcare settings: (i) e-CRM (Web-based CRM); (ii) implementing CRMS; and (iii) adopting CRMS. doi = 10.1016/j.csi.2020.103442 id = cord-320091-2lrqubdl author = Badawi, Alaa title = Prevalence of chronic comorbidities in dengue fever and West Nile virus: A systematic review and meta-analysis date = 2018-07-10 keywords = DENV; Nile; WNV; West; study summary = The objective of this study is to systematically review the existing literature on the prevalence of the most common non-communicable comorbidities related to the cluster of metabolic syndromes-associated diseases, such as diabetes mellitus, heart diseases, hypertension, asthma, stroke and obesity in flavivirus infections and to evaluate the difference of their prevalence in severe vs. Data extracted from the selected studies in duplicate by two reviewers and included the first author''s name, publication date, country, dates of recruitment, total sample size (divided to males and females), age estimates (from reported mean, median or the mid-point for age range of the highest subject frequency), procedures for case identification, type of flavivirus infection, severity of infection, prevalence of clinical manifestations (mild symptoms such as fever, headache, muscle pain, rash, and malaise together with severe symptoms as described below) and percentage of comorbidities including diabetes (both type I and type II, if mentioned), hypertension, heart diseases (due to the small sample size of individual conditions, we (Table 1) . doi = 10.1371/journal.pone.0200200 id = cord-033736-bsmqqi6j author = Bajraktari, Saranda title = Health-promoting and preventive interventions for community-dwelling older people published from inception to 2019: a scoping review to guide decision making in a Swedish municipality context date = 2020-10-14 keywords = effect; health; intervention; old; study summary = Eligible studies were: 1) interventions categorised as health promotion (HP) or primary prevention (PP) following the WHO''s definition [1, 2] and addressing behavioural risk factors, injury prevention, physical health, social and mental health, 2) including populations of community-living older people 65+ as of it being the lowest retirement age in the Nordic Countries, hence exclude the risk of missing relevant studies due to the age limitation, 3) implemented in a Nordic country (Denmark, Finland, Iceland, Norway, Sweden and Faroe Islands), 4) studies applying a randomized controlled trial design (RCT) for the evaluation of effects (research question six), 5) studies related to the identified RCTs addressing the remaining research question, e.g. experiences of participants, feasibility as well as studies on cost-effectiveness. Five studies had samples consisting only of female participants [32, Table 2 Detailed results concerning intervention content, effects on health outcomes, and feasibility aspects of included studies in the field of health-promoting and preventive interventions for community dwelling older people in the Nordic countries from inception to 2019 (Continued) doi = 10.1186/s13690-020-00480-5 id = cord-284880-xsh3wkqy author = Bandaly, Victor title = The Fate of Mengovirus on Fiberglass Filter of Air Handling Units date = 2017-06-28 keywords = air; filter; study; virus summary = The aim of this work is to study the characterization of viral bioaerosols in indoor environments and to understand the fate of mengovirus eukaryote RNA virus on glass fiber filter F7 used in AHU. Regarding the virus infectivity on the filter under a constant air flow, mengovirus was remained infectious during 10 h after aerosolization. From an average of 4.43 9 10 8 PFU L -1 of initial solution of virus aerosolized, 3.43 9 10 2 PFU cm -2 of infectious mengovirus was detected after 25 min of air flow. With a continuous air flow in the system, the persistence of mengovirus was assessed at different times and showed infectivity on the filter up to 10 h after aerosolization (Fig. 7) . Thus, time has an effect on the infectivity of the virus; this study showed that, with a continuous air flow in the doi = 10.1007/s12560-017-9310-8 id = cord-255901-nl9k8uwd author = Barasheed, Osamah title = Uptake and effectiveness of facemask against respiratory infections at mass gatherings: a systematic review date = 2016-03-29 keywords = Hajj; facemask; respiratory; study summary = Studies conducted in community or health care settings found facemasks to be generally effective against influenza-like illness (ILI) or even against severe acute respiratory syndrome (SARS) but its effectiveness against respiratory infections at MGs remains unknown. 15, 17 A review of non-pharmaceutical interventions against respiratory tract infections among Hajj pilgrims presented data on the uptake of facemask and acknowledged that compliance was generally poor, but did not evaluate its effectiveness during Hajj. A few studies showed that providing educational session on protective measures against respiratory infections (including facemask) before Hajj was associated with significantly higher uptake of facemasks among pilgrims. 68 Focused studies are required to investigate factors influencing facemask compliance among attendees of Hajj and other MGs. In this systematic review, pooled data of facemask effectiveness showed that participants who used facemask during Hajj are about 20% less likely to suffer from respiratory infections compared to those who do not use it. doi = 10.1016/j.ijid.2016.03.023 id = cord-336000-v88bq4bx author = Barco, Stefano title = Enoxaparin for primary thromboprophylaxis in ambulatory patients with coronavirus disease-2019 (the OVID study): a structured summary of a study protocol for a randomized controlled trial date = 2020-09-09 keywords = COVID-19; LMWH; SARS; VTE; day; line; patient; study summary = OBJECTIVES: The OVID study will demonstrate whether prophylactic-dose enoxaparin improves survival and reduces hospitalizations in symptomatic ambulatory patients aged 50 or older diagnosed with COVID-19, a novel viral disease characterized by severe systemic, pulmonary, and vessel inflammation and coagulation activation. The OVID study will show whether prophylactic-dose enoxaparin improves survival and reduces any hospitalizations in ambulatory patients aged 50 or older diagnosed with COVID-19, a novel viral disease characterized by severe systemic, pulmonary, and vessel inflammation and coagulation activation. <30% of the expected number of patients six months after the enrolment of the first patient, also based on the course of SARS-CoV2 infections in Switzerland;  when the safety of the participants is doubtful or at risk, respectively, based on recommendations received from DSMB committee;  changes in accepted clinical practice that make the continuation of a clinical trial unwise, including the results of similar studies or the publication of international guidances. doi = 10.1186/s13063-020-04678-4 id = cord-344075-ucd6ooob author = Bartoszek, Adrian title = Mental Well-Being (Depression, Loneliness, Insomnia, Daily Life Fatigue) during COVID-19 Related Home-Confinement—A Study from Poland date = 2020-10-12 keywords = COVID-19; DLF; pandemic; study summary = title: Mental Well-Being (Depression, Loneliness, Insomnia, Daily Life Fatigue) during COVID-19 Related Home-Confinement—A Study from Poland The aim of the study was to measure indicators of mental well-being in a Polish sample with regard to selected sociodemographic and health behavior data during home confinement related to COVID-19 pandemic. For this reason, our study aimed to measure mental well-being (levels of depression, insomnia, daily life fatigue, and loneliness) in a sample of the Polish population during COVID-19 related home confinement. The results have clearly shown that the pandemic and associated psychological stress are risk factors for sleep disorders and psychological diseases, e.g., the authors have shown that all of the elements of the Psychological Well-Being (PGWB) questionnaire (anxiety, depressed mood, positive well-being, self-control, general health, vitality) were significantly worse among study respondents than in previous general population data [33] . doi = 10.3390/ijerph17207417 id = cord-279935-asg71qtr author = Beasley, Lana O. title = Best Practices for Engaging Pregnant and Postpartum Women at Risk of Substance Use in Longitudinal Research Studies: a Qualitative Examination of Participant Preferences date = 2020-10-28 keywords = comment; participant; research; risk; study summary = Themes were organized into key engagement factors related to the following: (1) recruitment strategies, (2) enrollment, and (3) retention of high-risk pregnant and parenting women in longitudinal research studies. Overall, the current qualitative data provide preliminary data that enhance the understanding of a continuum of factors that impact engagement of high-risk pregnant and postpartum women in longitudinal research with current results indicating the need to prioritize recruitment, enrollment, and retention strategies in order to effectively engage vulnerable populations in research. These difficulties with recruitment and retention contribute to additional complications for research, including biased samples of convenience recruited through referrals from social and health agencies, limited sample diversity, deviations from the research design, and ethical issues associated with risk and benefits of participation and involvement with the criminal justice or child welfare system. doi = 10.1007/s42844-020-00019-1 id = cord-303187-ny4qr2a2 author = Belo, Vinícius Silva title = Abundance, survival, recruitment and effectiveness of sterilization of free-roaming dogs: A capture and recapture study in Brazil date = 2017-11-01 keywords = capture; dog; model; population; study summary = Despite the perceived need and usefulness of such parameter estimates and recommendations for the most appropriate approaches applicable under such study designs [30] , survival and recruitment estimates of free-ranging dogs had not been obtained using methods of capture and recapture. In this study, we present estimates of abundance, survival and recruitment rates, and the probabilities of capture of two free-roaming dog populations by means of analytical models for open populations, so far unexplored in previous studies. We estimated critical parameters (survival, recruitment and abundance) that describe the population dynamics of free-roaming dogs based on a capture and recapture study design and on models suitable for open populations. Our study demonstrated the increase in population size in both areas, the predominance and greater recruitment of males, the temporal variability in recruitment and in survival probabilities, the lack of effect of sterilization on population dynamics, the influence of abandon and of density-independent factors and a high demographic turnover. doi = 10.1371/journal.pone.0187233 id = cord-279718-r21k0gku author = Benseler, Anouk title = Antibiotic prophylaxis for urodynamic testing in women: a systematic review date = 2020-08-26 keywords = UDS; UTI; study summary = OBJECTIVES: This systematic review aims to update the assessment of the efficacy of antibiotic prophylaxis compared with placebo or no treatment for prevention of urinary tract infection in females over the age of 18 years undergoing UDS. None of the studies included were powered to show a significant change in the incidence of urinary tract infection following UDS in female patients receiving antibiotic prophylaxis versus no prophylaxis. CONCLUSIONS: Similar to the 2012 Cochrane review on this subject, this systematic review demonstrated that antibiotic prophylaxis may decrease bacteriuria in women post UDS; however, further research is required to assess its effect on urinary tract infections in this context. In this study, we aim to update the 2012 Cochrane review and present the first female-specific systematic review with the primary objective of evaluating the efficacy of antibiotic prophylaxis compared with placebo or no treatment for prevention of UTI in females over the age of 18 years undergoing UDS. doi = 10.1007/s00192-020-04501-3 id = cord-276015-id15u3br author = Beran, Jiří title = Inosine pranobex is safe and effective for the treatment of subjects with confirmed acute respiratory viral infections: analysis and subgroup analysis from a Phase 4, randomised, placebo-controlled, double-blind study date = 2016-11-07 keywords = influenza; pranobex; study; subject summary = This study compared the efficacy and safety of inosine pranobex versus placebo in subjects with clinically diagnosed influenza-like illness, including subjects with laboratory-confirmed acute respiratory viral infections. In the subgroup analysis for subjects less than 50 years of age, statistically significant differences in time to resolution of influenza-like symptoms that favoured the inosine pranobex group over the placebo group were observed in those without related ongoing disease and those who were non-obese (BMI <30 kg/m(2)). CONCLUSIONS: The study results indicate the safety of inosine pranobex for the treatment of subjects with confirmed acute respiratory viral infections and confirm the efficacy of inosine pranobex versus placebo in healthy non-obese subjects less than 50 years of age with clinically diagnosed influenza-like illnesses. doi = 10.1186/s12879-016-1965-5 id = cord-282526-b8tky324 author = Berger Gillam, T. title = Norwich COVID-19 Testing Initiative: feasibility project evaluation date = 2020-09-23 keywords = COVID-19; participant; study summary = This study aimed to pilot mass COVID-19 testing on a university research park, to assess the feasibility and acceptability of scaling up to all staff and students. The study offered four COVID-19 PCR swabs to all staff and students on the site over a twoweek period, with the aim of piloting communications, logistics and laboratory processes, and assessing participant acceptability in preparation for larger-scale testing. . https://doi.org/10.1101/2020.09.22.20199455 doi: medRxiv preprint 3 After the completion of the feasibility project, participants who had returned at least one swab were emailed a link to complete a short online participant feedback questionnaire, including questions on demographics and their experience of the project. A strength of this study is that it trialled the feasibility of repeat testing for COVID-19 in a relatively large, asymptomatic population within a research park and university campus. doi = 10.1101/2020.09.22.20199455 id = cord-030922-l7xuu9a5 author = Bergström, Anna title = The use of the PARIHS framework in implementation research and practice—a citation analysis of the literature date = 2020-08-27 keywords = Health; PARIHS; Research; evidence; framework; implementation; study summary = BACKGROUND: The Promoting Action on Research Implementation in Health Services (PARIHS) framework was developed two decades ago and conceptualizes successful implementation (SI) as a function (f) of the evidence (E) nature and type, context (C) quality, and the facilitation (F), [SI = f (E,C,F)]. The PARIHS framework is a commonly used conceptual framework [1, 4] that posits successful implementation (SI) as a function (f) of the nature and type of evidence (E) (including research, clinical experience, patient experience, and local information), the qualities of the context (C) of implementation (including culture, leadership, and evaluation), and the way the implementation process is facilitated (F) (internal and/or external person acting as a facilitator to enable the process of implementation); SI = f(E,C,F). Categorical data were analyzed using descriptive statistics, whereas the open-ended items were analyzed qualitatively [16] , including the collated extractions of data to illustrate each of the four types of use (i.e., how the PARIHS framework was depicted in terms of (1) planning and delivering an intervention, (2) analysis, (3) evaluation of study findings, and/or (4) in any other way). doi = 10.1186/s13012-020-01003-0 id = cord-287958-tcn2hlmo author = Bhattacharya, Subhasis title = The behaviour of Infection, Survival and Testing Effort Variables of SARS-CoV-2: A Theoretical Modelling based on Optimization Technique date = 2020-11-11 keywords = effort; identification; study summary = title: The behaviour of Infection, Survival and Testing Effort Variables of SARS-CoV-2: A Theoretical Modelling based on Optimization Technique Consideration of improper functional relation in case of identification, survival and testing effort variables of the disease may be the cause of such non-universal applicability. METHODS: Present study using optimization techniques try to find the general functional form for the variables like identification of the carrier''s and testing effort. Under such construction the study considers the following restrictions on the growth function of infection and identification function of infection. The study also assumes a linear effort function which is of the form and the identification function will be = 0 + = ( 0 + ).…… (6) In equilibrium, under the logistic growth function for infection will be, From such construction, the study consider net benefit from the effort applied for the identification of the infected is doi = 10.1016/j.rinp.2020.103568 id = cord-252984-79jzkdu2 author = Bickman, Leonard title = Improving Mental Health Services: A 50-Year Journey from Randomized Experiments to Artificial Intelligence and Precision Mental Health date = 2020-07-26 keywords = Bickman; Health; Mental; RCT; approach; datum; machine; research; service; study; treatment summary = I describe five principal causes of this failure, which I attribute primarily, but not solely, to methodological limitations of RCTs. Lastly, I make the case for why I think AI and the parallel movement of precision medicine embody approaches that are needed to augment, but probably not replace, our current research and development efforts in the field of mental health services. (1) harmonize terminology and specify MBC''s core components; (2) develop criterion standard methods for monitoring fidelity and reporting quality of implementation; (3) develop algorithms for MBC to guide psychotherapy; (4) test putative mechanisms of change, particularly for psychotherapy; (5) develop brief and psychometrically strong measures for use in combination; (6) assess the critical timing of administration needed to optimize patient outcomes; (7) streamline measurement feedback systems to include only key ingredients and enhance electronic health record interoperability; (8) identify discrete strategies to support implementation; (9) make evidence-based policy decisions; and (10) align reimbursement structures. doi = 10.1007/s10488-020-01065-8 id = cord-310215-11srk6iq author = Bielinis, Ernest title = A Novel Anti-Environmental Forest Experience Scale to Predict Preferred Pleasantness Associated with Forest Environments date = 2020-09-16 keywords = AEFES; environment; forest; study summary = In this study, a method for predicting the preferred pleasantness induced by different forest environments, represented by virtual photographs, was proposed and evaluated using a novel Anti-Environmental Forest Experience Scale psychometric test. Insofar as there is some possibility of predicting the level of psychological relaxation and therefore preferred pleasantness induced by viewing different forest landscapes, it is important to propose new concepts for these contexts. The reliability of these scales provides evidence that an Anti-Environmental Forest Experience can help predict the pleasantness induced by viewing forest landscapes and can be useful in predicting potential benefits that might be obtained by a subject from nature-based therapy. To sum up, the AEFES is a reliable and valid instrument with practical use for measuring an anti-environmental forest experience, which might be useful for the prediction of the preferred pleasantness of subjects towards forest environments. doi = 10.3390/ijerph17186731 id = cord-281051-i229xv0o author = Bishop-Williams, Katherine E. title = A protocol for a systematic literature review: comparing the impact of seasonal and meteorological parameters on acute respiratory infections in Indigenous and non-Indigenous peoples date = 2017-01-26 keywords = ARI; indigenous; respiratory; study summary = This protocol outlines our process for conducting a systematic review to investigate whether associations between ARI and seasonal or meteorological parameters differ between Indigenous and non-Indigenous groups residing in the same geographical region. This paper outlines a protocol for conducting a systematic review to investigate whether associations between ARI and seasonal or meteorological parameters differ between Indigenous and non-Indigenous groups residing in the same geographical region. This research builds from the United Nations Declaration of the Rights of Indigenous Peoples [13] understanding of the term Indigenous peoples, which states that an Indigenous person self-identifies as Indigenous; has historical continuity Table 1 Inclusion and exclusion criteria for a systematic literature review investigating the impact of seasonal and meteorological parameters on acute respiratory infection (ARI) in Indigenous and non-Indigenous peoples doi = 10.1186/s13643-016-0399-x id = cord-102417-xn7m3wqp author = Blake, T. title = Psoriatic disease and body composition: a systematic review of the literature date = 2020-05-21 keywords = body; fat; study summary = Patients with psoriatic disease reveal defined body composition changes that are independent of obesity and the customary metabolic syndrome, including higher overall body fat, visceral fat and sarcopenia. Types of studies • Publication date 1999 (inclusive) -present • Studies from any geographical location • English language • Published studies (including conference papers) • Grey literature (not published in a peer-reviewed journal) including dissertations/theses • Any quantitative study (RCT, non-RCT, observational, cohort, case control) • Studies using qualitative methods of analysis (to describe patterns or themes raised by studies) seeking to understand body composition phenotypes of psoriatic disease. In general, 24 studies confirmed discrete biological and body composition changes in patients with psoriatic disease, which correlated positively with other indicators of metabolic syndrome, including waist circumference, waist-to-hip ratio, weight, BMI, plasma concentrations of low-density lipoprotein (LDL)cholesterol, leptin and apolipoprotein-B (apo-B). doi = 10.1101/2020.05.18.20104802 id = cord-285244-2suwmika author = Blau, Ina title = Violation of digital and analog academic integrity through the eyes of faculty members and students: Do institutional role and technology change ethical perspectives? date = 2020-07-22 keywords = VAI; academic; digital; student; study summary = This study aimed to address the gap in the literature through a comprehensive comparison of different types of violations of academic integrity (VAI), cheating, plagiarism, fabrication and facilitation (Pavela in J College Univ Law 24(1):1–22, 1997), conducted in analog versus digital settings, as well as students'' and faculty members'' perceptions regarding their severity. 4. Among students, are there differences in perceptions regarding the severity of different analog and digital VAI engaged in by students (cheating, plagiarism, fabrication, and facilitation) and suggested penalties for these types of violations according to sociodemographic variables (ethnicity, gender, and degree)? To examine research questions 3 and 4 exploring differences in perceptions between the study groups (faculty and students, and students of different ethnic groups) regarding the severity of each type of VAI (cheating, plagiarism, fabrication, and facilitation) and suggested penalties for these behaviors, repeated measures ANOVAs were conducted. doi = 10.1007/s12528-020-09260-0 id = cord-284332-p4c1fneh author = Bosma, Karen J. title = Pharmacotherapy for Prevention and Treatment of Acute Respiratory Distress Syndrome: Current and Experimental Approaches date = 2012-09-19 keywords = ALI; ARDS; acute; lung; mortality; patient; respiratory; study summary = [47] Although both of these studies were conducted prior to the 1994 AECC definition, ARDS was strictly defined in the aforementioned studies, including a PaO 2 /FiO 2 ratio <150 or intrapulmonary shunt >20% in patients requiring mechanical ventilation and who had diffuse infiltrates on chest radiograph without clinical evidence of heart failure as pulmonary arterial occlusion pressures were <18 mmHg. Building on the results of these two studies, Sinuff and colleagues [48] developed practice guidelines for prophylactic ketoconazole use, and tested the implementation and efficacy of these guidelines in two ICUs (one control and one active comparator). [119] A phase II study enrolling 98 patients with ALI compared an antioxidant enteral feeding formula containing eicosapentaenoic acid, g-linolenic acid and antioxidant vitamins with placebo, and observed improved oxygenation, reduced pulmonary inflammation, fewer days of mechanical ventilation and fewer non-pulmonary organ failures in the treatment arm, although there was no difference in mortality between this approach and the control group. doi = 10.2165/10898570-000000000-00000 id = cord-324635-27q3nxte author = Bouza, Emilio title = The situation of infection in the elderly in Spain: a multidisciplinary opinion document date = 2020-09-08 keywords = Spain; age; care; elderly; health; home; infection; old; patient; study; year summary = Thus, for long-term care facility (LTCF) residents and in hospitalised elderly people, UTI is the number one cause of infection and is the second most common in older women living in the community [19] . The first data on infection in nursing homes in Spain come from the EPINGER study, conducted in community health centres in Catalonia, which reported a prevalence of 6.5%, although it should be pointed out that in Catalonia the concept of the community health centre would include medium-long term patients, while in the rest of the Spanish autonomous communities this concept would be limited to nursing homes [40] . This is a multi-centre system for monitoring nosocomial infections, based on the production of an annual prevalence study, which has been conducted since 1990 in a large group of hospitals in Spain and was promoted by the Spanish Society of Preventive Medicine, Public Health and Hygiene. The studies reviewed allow us to estimate a prevalence of infection of between 4 and 10% in nursing homes in Spain, depending on their complexity, and between 6 and 9% in hospitalised elderly people. doi = 10.37201/req/057.2020 id = cord-329999-flzqm3wh author = Buchanan, Tom title = Why do people spread false information online? The effects of message and viewer characteristics on self-reported likelihood of sharing social media disinformation date = 2020-10-07 keywords = Facebook; Study; Table; Twitter; share summary = Four studies (total N = 2,634) explored the effect of message attributes (authoritativeness of source, consensus indicators), viewer characteristics (digital literacy, personality, and demographic variables) and their interaction (consistency between message and recipient beliefs) on self-reported likelihood of spreading examples of disinformation. Descriptive statistics for participant characteristics (personality, conservatism, new media literacy and age) and their reactions to the stimuli (likelihood of sharing, belief the stories were likely to be true, and rating of likelihood that they had seen them before) are summarised in Table 2 . This evaluated the extent to which digital media literacy (NMLS), authority of the message source, consensus, belief in veracity of the messages, consistency with participant beliefs (operationalised as the total SECS conservatism scale score), age and personality (Extraversion, Conscientiousness, Agreeableness, Openness to Experience and Neuroticism), predicted self-rated likelihood of sharing the posts. doi = 10.1371/journal.pone.0239666 id = cord-348570-plds5kbn author = Buneviciene, Inesa title = Can mHealth interventions improve quality of life of cancer patients? A systematic review and meta-analysis date = 2020-10-20 keywords = Cancer; intervention; patient; study summary = In this systematic-review and meta-analysis, we explored the possible impact of health interventions delivered via mHealth tools on HRQoL of cancer patients. We aimed to systematically review studies that investigated the possible impact of health interventions delivered via mHealth tools on the HRQoL of patients with cancer and to pool the reported results from the original studies in a meta-analysis, when feasible. Finally, a healthy eating and physical activity feedback app (BENECA) administered to 80 overweight or obese breast cancer patients improved global health perception, physical, emotional, cognitive and social functioning domains, in addition to fatigue dyspnea and insomnia symptom severity, as evaluated by the EORTC-QLQ-C30 questionnaire [35] . One study in 114 breast cancer patients receiving chemotherapy randomized patients to either an app-based support program (mHealth intervention group) or to usual care (control group), which comprised a health supportive care during chemotherapy as inpatients. doi = 10.1016/j.critrevonc.2020.103123 id = cord-315149-71bmj5il author = Caballero Bermejo, Antonio F. title = Sarilumab versus standard of care for the early treatment of COVID-19 pneumonia in hospitalized patients: SARTRE: a structured summary of a study protocol for a randomised controlled trial date = 2020-09-16 keywords = COVID-19; IL-6; SOC; il6; patient; study summary = The aim of the present study is to evaluate if an earlier therapeutic intervention with sarilumab plus SOC (including corticosteroids) may be more effective than current standard of care alone, in preventing progression to respiratory failure in COVID-19 infected patients with interstitial pneumonia. The aim of the present study is to evaluate if an earlier therapeutic intervention with sarilumab plus SOC may be more effective than current standard of care alone, which according to our local protocol includes weight adjusted corticosteroids doses, in preventing progression to respiratory failure in COVID-19 infected patients with interstitial pneumonia. Patients randomized to the control arm (CS + SOC group without sarilumab) progressing to severe respiratory failure fulfilling criteria for treatment with anti-IL6 inhibitors according to clinical practice guidelines, as defined by the presence of Brescia-COVID SARTRE STUDY EudraCT Number: 2020-002037-15 Version 2.0 (May 05th 2020) Scale 2-3 plus inflammatory markers, will be offered the option to be rescued with sarilumab at the same doses and be included in an open-label follow-up phase. doi = 10.1186/s13063-020-04633-3 id = cord-267389-v2ihhtl0 author = Canevelli, Marco title = The Pipeline of Therapeutics Testing During the Emergency Phase of the COVID-19 Outbreak date = 2020-09-24 keywords = COVID-19; phase; study summary = The clinicaltrials.gov database and the European Union (EU) Clinical Trials Register were investigated on March 31, 2020, to identify all ongoing phase 1–4 research protocols testing pharmacological interventions targeting SARS-CoV-2 infection and/or clinical syndromes associated with COVID-19. In this article, we provide a summary of the interventional studies that have been conducted worldwide to test the efficacy and/or safety/tolerability of pharmacological compounds against COVID-19 in the emergency phase of the pandemic. The following data were abstracted by three authors (F.T., Ga.R., and Gi.R.) from the selected protocols: NCT (the unique identification code assigned by clinicaltrials.gov) and/or EudraCT codes; study phase; allocation and masking procedures; tested compound(s); way of administration; mechanism of action; primary outcome measure(s); expected primary completion date; expected number of participants; age range of participants; targeted COVID-19 related condition; sponsor; and location. doi = 10.3389/fmed.2020.552991 id = cord-344498-mwgccbfo author = Casado-Aranda, Luis-Alberto title = Analysis of the Scientific Production of the Effect of COVID-19 on the Environment: A Bibliometric Study date = 2020-11-03 keywords = COVID-19; Science; Scopus; effect; pandemic; study summary = These publications can be broken down into six main themes: (i) a sharp reduction in air pollution and an improvement of the level of water pollution; (ii) the relationship of wind speed (positive), ultraviolet radiation (positive) and humidity (negative) with the rate of infections; (iii) the effect of the pandemic on the food supply chain and waste habits; (iv) wastewater monitoring offers a great potential as an early warning sign of COVID-19 transmission; (v) artificial intelligence and smart devices can be of great use in monitoring citizen mobilization; and (vi) the lessons gleaned from the pandemic that help define actions to mitigate climate change. The intention of the current study is to offer a first straightforward report on the evolution of publications combining the effect of COVID-19 on the environment since the outset of the pandemic, as well as to identify the main lines of research that are surging as a result of the crisis and establish a research agenda for environmental scholars. doi = 10.1016/j.envres.2020.110416 id = cord-295786-cpuz08vl author = Castillo-Sánchez, Gema title = Suicide Risk Assessment Using Machine Learning and Social Networks: a Scoping Review date = 2020-11-09 keywords = model; social; study; suicide summary = This scoping review aims to identify the machine learning techniques used to predict suicide risk based on information posted on social networks. This scoping review aims to identify the current ML techniques used to predict suicide risk based on information posted on social networks. The authors have performed a systematic review to identify relevant papers that use suicide risk assessment models in social networks. To select the relevant studies on this topic, the authors defined the following inclusion criteria: & The studies include algorithms or models to estimate suicide risk using the social network. The research papers were excluded if they were not written in the English language, do not include a specific suicide intervention or do not report information regarding technical aspects of the model/algorithm used to detect suicide risk on social networks. The results of the application of artificial intelligence algorithms or models for suicide risk identification using data collected from social networks have been analyzed in this study. doi = 10.1007/s10916-020-01669-5 id = cord-354592-vqws942c author = Cauvin, Annick J. title = Advantages and Limitations of Commonly Used Nonhuman Primate Species in Research and Development of Biopharmaceuticals date = 2015-03-20 keywords = NHP; human; monkey; study summary = The marmoset also has been used as a nonrodent second species in drug safety assessment of new chemical entities (NCEs) and, more recently, of biopharmaceuticals based on side effects, findings of given drugs, and metabolizing enzymes or receptors found to be similar to humans [16] [17] [18] [19] ; because of the closer phylogenetic relationship to humans than other second species such as the dog, common marmosets may be more suitable for certain types of PART 7 NHP-SPECIFIC ASPECTS OF STANDARD TOXICOLOGY STUDIES pharmacokinetic and toxicological screening. Conversely, study designs for use with NHPs do not cover all aspects of reproduction (e.g., direct fertility assessment through mating or egg implantation-pregnancy cannot be confirmed until day 20 of gestation) and so may not allow a full evaluation of the specific risks in humans. The cynomolgus monkey has been used as a relevant toxicology species for immunostimulatory agents such as Toll-like receptor agonists; however, while special recognition regarding the clinical risk of systemic cytokine release for certain targets is warranted, the NHP is not always predictive of this potential toxicity in humans. doi = 10.1016/b978-0-12-417144-2.00019-6 id = cord-345611-xv62h83a author = Cavalcanti, A. B. title = Hydroxychloroquine alone or in combination with azithromycin to prevent major clinical events in hospitalised patients with coronavirus infection (COVID-19): rationale and design of a randomised, controlled clinical trial date = 2020-05-26 keywords = COVID-19; patient; study summary = Methods and analysis: We describe the rationale and design of an open-label pragmatic multicentre randomised (concealed) clinical trial of 7 days of hydroxychloroquine (400 mg BID) plus azithromycin (500 mg once daily), hydroxychloroquine 400 mg BID, or standard of care for moderately severe hospitalised patients with suspected or confirmed COVID-19 (in-patients with up to 4L/minute oxygen supply through nasal catheter). The control group receive the current standard of care treatment for COVID-19, which includes daily monitoring with clinical assessment of the attending physician, routine laboratory tests (blood count, urea, creatinine, liver enzymes and bilirubin, c-reactive protein) at the discretion of the attending physician, respiratory and motor physiotherapy, surveillance of vital parameters according to the patient''s location (inpatient unit and ICU), at least once per period, which may be more frequent CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. doi = 10.1101/2020.05.19.20106997 id = cord-323463-osf6t7cw author = Cercenado, Emilia title = Update on bacterial pathogens: virulence and resistance date = 2008-04-30 keywords = MRSA; PVL; Staphylococcus; infection; isolate; patient; strain; study summary = This paper focus on a variety of diseases that pose major clinical and public health challenges today; and include infections produced by community-acquired methicillin-resistant Staphylococcus aureus and S. Although predictions during the 20th century indicated that the incidence of infectious diseases would diminish as a result of improvements in sanitation and by the introduction of many vaccines and antibiotics, at the beginning of the 21st century the rates of infections produced by new pathogens or by reemerging microorganisms possessing new virulence or resistance phenotypes is increasing, threatening the overall human health [1] [2] [3] [4] [5] . It is in this scenario where community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) has emerged as the most common pathogen isolated from patients with skin and soft-tissue infections attending to the emergency departments in many United States and Australian cities 8, 9 , and at present, its incidence is increasing in other parts of the world 10, 11 . doi = 10.1016/s0213-005x(08)76378-x id = cord-319323-1qt7vf59 author = Chakraborty, Amartya title = Around the world in 60 days: an exploratory study of impact of COVID-19 on online global news sentiment date = 2020-10-21 keywords = case; news; number; sentiment; study summary = The proposed work takes up the challenge of mining a comprehensive set of online news texts, for determining the prevailing sentiment in the context of the ongoing pandemic, along with a statistical analysis of the relation between actual effect of COVID-19 and online news sentiment. The current work statistically determines how and after what amount of delay, the number of affected patients, and number of deaths due to COVID-19, impacts the news sentiment in regional and world-wide news, -The authors also analyze other relevant factors that contribute to rise or fall of global news sentiment related to particular countries. A visual analysis of these images reveals how the observations are generally applicable throughout the data from different countries; that is, whether the global news sentiment about a country is actually affected by the daily trends in number of new cases or deaths. doi = 10.1007/s42001-020-00088-3 id = cord-324786-8k81jetq author = Chang, Anne B title = Antibiotics for bronchiectasis exacerbations in children: rationale and study protocol for a randomised placebo-controlled trial date = 2012-08-31 keywords = bronchiectasis; child; exacerbation; respiratory; study summary = Our study tests the hypothesis that both oral azithromycin and amoxicillin-clavulanic acid are superior to placebo at improving resolution rates of respiratory exacerbations by day 14 in children with bronchiectasis unrelated to cystic fibrosis. Our multicentre, double-blind RCT is designed to determine if azithromycin and amoxicillin-clavulanic acid, compared with placebo, improve symptom resolution on day 14 in children with acute respiratory exacerbations. Early and effective management of bronchiectasis exacerbations in children may lead to reduced hospitalisations, better quality of life (QOL) and improved future adult lung function. Our study tests the primary hypothesis that both oral azithromycin and amoxicillin-clavulanic acid are superior to placebo in improving the resolution rate of respiratory exacerbations by day 14 in children with non-CF bronchiectasis. We are conducting a multicentre, parallel group, double-blind placebo RCT (with concealed allocation) to assess the impact of treatment with antibiotics (azithromycin or amoxicillinclavulanic acid) in children with an exacerbation of bronchiectasis. doi = 10.1186/1745-6215-13-156 id = cord-267608-0odu8lus author = Chen, Daohong title = Innovative highlights of clinical drug trial design date = 2020-06-03 keywords = clinical; drug; study; trial summary = Accordingly taking the advantage of interim analysis based on novel biomarker approach for detecting the pathogenesis-specific molecular alteration(s), an adaptive clinical study can select the drug-sensitive sub-population from patients with initially targeted disease or an alternative indication, to continue the investigation for an optimized therapeutic efficacy [7] . While human bioequivalence study is increasingly contributing to evaluation of emerging formulation and bio-similar agents besides chemical generics [4] , several adaptive trial designs have been capable of translating the scientific breakthroughs into novel therapeutic benefits with shorter processing time and lower financial costs, to address the unmet clinical needs [3, 19] . Of note, to preserve the strength of clear defining efficacy and safety of tested drugs, the innovative designs of clinical study are substantially overlapped with classic trial protocols of three phases which still serve as the mainstream approach of clinical investigation [3, 7] . doi = 10.1016/j.trsl.2020.05.007 id = cord-318342-eipscagh author = Chen, Juan title = The Impact of COVID-19 on Blood Glucose: A Systematic Review and Meta-Analysis date = 2020-10-05 keywords = COVID-19; SARS; study summary = Results: Three studies reported blood glucose and HbA1c according to the severity of COVID-19 and were included in this meta-analysis. It remains unclear regarding the effect of severity of COVID-19 infection on glycemic parameters, including blood glucose and glycated haemoglobinA1c (HbA1c). Finally, three papers were included in the meta-analysis that evaluated blood glucose and/or HbA1c levels according to the severity of COVID-19 (17) (18) (19) . The z-test result for overall effects was statistically significant (P < 0.001), indicating a significantly greater elevation in blood glucose in patients with severe COVID-19 infection than those in the mild group. In the present meta-analysis, we found that blood glucose was significantly higher in patients with severe COVID-19 than those with mild COVID-19 (WMD 2.21, 95% CI: 1.30-3.13, P < 0.001, I 2 = 0%). doi = 10.3389/fendo.2020.574541 id = cord-003364-hp8psl4s author = Chen, Xiantao title = Lipid Transporter Activity-Related Genetic Polymorphisms Are Associated With Steroid-Induced Osteonecrosis of the Femoral Head: An Updated Meta-Analysis Based on the GRADE Guidelines date = 2018-12-03 keywords = ABCB1; SONFH; study summary = doi = 10.3389/fphys.2018.01684 id = cord-298257-uptgv2xv author = Cheng, Wenwen title = Efficacy and Safety of Corticosteroid Treatment in Patients With COVID-19: A Systematic Review and Meta-Analysis date = 2020-09-09 keywords = COVID-19; corticosteroid; study summary = Compared with the control treatments, corticosteroid therapy was associated with clinical recovery (RR = 1.30, 95% CI [0.98, 1.72]) and a significantly shortened length of ICU hospitalization (RR = −6.50; 95% CI [−7.63 to −5.37]), but it did not affect the mortality ((RR = 1.59; 95% CI [0.69–3.66], I(2) = 93.5%), utilization of mechanical ventilation (RR = 0.35; 95% CI [0.10, 1.18]), duration of symptoms (WMD = 1.69; 95% CI [−0.24 to 3.62]) or virus clearance time (RR = 1.01; 95% CI [−0.91 to 2.92], I(2) = 57%) in COVID-19 patients. to explore the efficacy of the early use of short-term corticosteroids compared with a control treatment in hospitalized patients with severe COVID-19 pneumonia in Wuhan Union Hospital and reported a remarkable improvement of clinical symptoms and chest computed tomography (CT) findings . All the included retrospective cohort studies (without control group) and case studies did not report virus clearance time in patients with COVID-19 after corticosteroid treatment. doi = 10.3389/fphar.2020.571156 id = cord-282194-0sjmf1yn author = Cherak, Stephana J. title = Impact of social media interventions and tools among informal caregivers of critically ill patients after patient admission to the intensive care unit: A scoping review date = 2020-09-11 keywords = caregiver; medium; social; study summary = title: Impact of social media interventions and tools among informal caregivers of critically ill patients after patient admission to the intensive care unit: A scoping review The purpose of this scoping review was to summarize existing research on the impact of social media interventions and tools among informal caregivers of critically ill patients after patient admission to the intensive care unit (ICU). For the purposes of this review, we defined: (1) a caregiver as any informal (i.e., non-clinical) person who regularly provides support to the patient and is in some way directly implicated in the patient''s care or directly affected by the patient''s health problem (e.g., family, friend); (2) social media as any form of electronic communication that allow users to share information and other content and create online communities; and (3) critically ill patients as any persons who are currently admitted to an intensive care unit (ICU) or had previously been admitted to an ICU. doi = 10.1371/journal.pone.0238803 id = cord-283340-ksyd5l56 author = Choi, Geun Joo title = The Potential Role of Dyslipidemia in COVID-19 Severity: an Umbrella Review of Systematic Reviews date = 2020-09-21 keywords = COVID-19; review; study summary = OBJECTIVE: The aim of this study was to analyze the available knowledge about the potential association between dyslipidemia and the severity of coronavirus disease 2019 (COVID-19) as reported in previous published systematic reviews. Specifically, we conducted an umbrella review to evaluate the findings of systematic reviews and/or metaanalyses that investigated the relationship of dyslipidemia and severity of COVID-19 infection and to assess the evidence regarding potential limitations and the consistency of findings. The following criteria were applied to identify the articles to be included in the present umbrella review: (1) systematic reviews and/or meta-analyses; (2) studies involving adults who tested positive for COVID-19; and (3) studies reporting the association between dyslipidemia and COVID-19 infection. Two authors (G.J.C. and H.M.K.) independently extracted the outcomes on the relationship of dyslipidemia or non-dyslipidemia and lipid profile with COVID-19 infection severity from the identified systematic reviews and meta-analyses. doi = 10.12997/jla.2020.9.3.435 id = cord-007321-7gi6xrci author = Chow, Anthony W. title = Evaluation of New Anti-Infective Drugs for the Treatment of Respiratory Tract Infections date = 1992-11-17 keywords = AOM; MEE; acute; clinical; patient; study; therapy summary = These guidelines for the evaluation of drugs for the treatment of respiratory tract infections include acute streptococcal pharyngitis and tonsillitis, acute otitis media, acute and chronic sinusitis, acute exacerbations of chronic bronchitis, and acute infectious pneumonia (table 1). This is often the case in otitis media, sinusitis, and pneumonia, when the use of invasive procedures such as tympanocentesis, sinus puncture, or transtracheal aspiration to confirm microbial eradication in the patient who is improving clinically generally is considered unjustified. Patients eligible for study entrance are children or adults with symptomatic pharyngitis or tonsillitis of acute onset clinically consistent with infection with group A I3-hemolytic streptococci and from whom group A (3-hemolytic streptococci have been isolated in cultures of throat -swab specimen or for whom a rapid screening test has indicated the presence of streptococci. doi = 10.1093/clind/15.supplement_1.s62 id = cord-003062-qm8kalyt author = Chowdhury, Fazle Rabbi title = The association between temperature, rainfall and humidity with common climate-sensitive infectious diseases in Bangladesh date = 2018-06-21 keywords = Bangladesh; Climate; disease; study summary = doi = 10.1371/journal.pone.0199579 id = cord-350424-gwkxxkuu author = Cleland, Brice T. title = Feasibility and Safety of Transcranial Direct Current Stimulation in an Outpatient Rehabilitation Setting After Stroke date = 2020-10-09 keywords = participant; study; tdcs summary = title: Feasibility and Safety of Transcranial Direct Current Stimulation in an Outpatient Rehabilitation Setting After Stroke Transcranial direct current stimulation (tDCS) has strong potential for outpatient clinical use, but feasibility and safety of tDCS has only been evaluated in laboratory and inpatient clinical settings. The application of tDCS was incorporated into the standard time for the treatment session (55 min) and applied during the~15-min warmup exercise performed at each participant''s comfortable intensity and personalized based on each patient''s baseline self-selected gait speed. The effect of single session bi-cephalic transcranial direct current stimulation on gait performance in sub-acute stroke: A pilot study Effects of transcranial direct current stimulation over the supplementary motor area body weight-supported treadmill gait training in hemiparetic patients after stroke Effect of transcranial direct current stimulation on severely affected arm-hand motor function in patients after an acute ischemic stroke: A pilot randomized control trial doi = 10.3390/brainsci10100719 id = cord-337316-ialg7d7e author = Cori, Liliana title = Risk Perception of Air Pollution: A Systematic Review Focused on Particulate Matter Exposure date = 2020-09-03 keywords = air; perception; pollution; study summary = To systematically examine the articles selected, the explored dimensions of perception (understanding/sensorial perception; reactions/psychological consequences; reactions/physical consequences; behaviors) were categorized by 20 features (awareness; belief; knowledge; concern; risk perception; worry; fear; outrage; familiarity; trust; annoyance; anxiety; life quality change; self-reported health symptoms; avoidance of the problem; search for information; exposure reduction; proactivity; request for action; and acceptance). Cross-sectional study by questionnaire to evaluate relationships between concern on health effects of air pollution and personal and environmental factors. The results of this analysis, presented in Table 2 , showed that for "understanding" (44) , most of the articles focused on awareness (32); for "reactions/psychological" (48), more represented risk perception (23); for "reactions/physical" (44) , the declared symptoms were most represented (26); and for "behaviours" (38) , exposure reduction (13) and search for information (12) were the most represented. People, place and pollution: Investigating relationships between air quality perceptions, health concerns, exposure, and individual-and area-level characteristics doi = 10.3390/ijerph17176424 id = cord-102796-rr8qet8c author = Counotte, Michel J title = Emergence of evidence during disease outbreaks: lessons learnt from the Zika virus outbreak date = 2020-03-18 keywords = ZIKV; study summary = We are continuously facing new disease outbreaks, including the new coronavirus (SARS-nCoV-2) in December 2019.The objective of this study was to describe the accumulation of evidence during the 2013-2016 Zika virus (ZIKV) outbreak in the Pacific and the Americas related to aetiological causal questions about congenital abnormalities and Guillain-Barre syndrome. In the 2013-2016 ZIKV outbreak, case reports, case series and basic research studies were published first. A strength of this study is the pre-specified hypothesis about the time to publication of aetiological 139 research and the use of data from systematic reviews that had screened and selected studies that 140 addressed the causal relationship between ZIKV infection and its adverse outcomes. The accumulation of evidence over time in new causal problems seems to follow a hierarchy where 225 case reports and case series were rapidly followed by basic research. Syndrome outbreak associated with Zika virus infection in French Polynesia: A case-control study doi = 10.1101/2020.03.16.20036806 id = cord-308964-y18nru1d author = Couper, Keith title = COVID-19 in cardiac arrest and infection risk to rescuers: a systematic review date = 2020-04-20 keywords = COVID-19; compression; study summary = The aim of this review was to identify the potential risk of transmission 33 associated with key interventions (chest compressions, defibrillation, cardiopulmonary 34 resuscitation) to inform international treatment recommendations. The aim of this review was to identify the potential risk of transmission 33 associated with key interventions (chest compressions, defibrillation, cardiopulmonary 34 resuscitation) to inform international treatment recommendations. Methods: We undertook a systematic review comprising three questions: 1) aerosol 37 generation associated with key interventions; 2) risk of airborne infection transmission 38 associated with key interventions; and 3) the effect of different personal protective 39 equipment strategies. Methods: We undertook a systematic review comprising three questions: 1) aerosol 37 generation associated with key interventions; 2) risk of airborne infection transmission 38 associated with key interventions; and 3) the effect of different personal protective 39 equipment strategies. Our first two research questions examined the association between key resuscitation 99 interventions (chest compressions, defibrillation, CPR) and aerosol generation and airborne 100 transmission of infection. doi = 10.1016/j.resuscitation.2020.04.022 id = cord-321697-yua3apfi author = Crigna, Adriana Torres title = Cell-free nucleic acid patterns in disease prediction and monitoring—hype or hope? date = 2020-10-29 keywords = CRC; cancer; cell; dna; increase; patient; plasma; study summary = This article highlights the involvement of circulating CFNAs in local and systemic processes dealing with the question, whether specific patterns of CFNAs in blood, their detection, quantity and quality (such as their methylation status) might be instrumental to predict a disease development/progression and could be further utilised for accompanying diagnostics, targeted prevention, creation of individualised therapy algorithms, therapy monitoring and prognosis. Especially severe, prolonged and/ or chronic stress of any origin such as exercise-induced oxidative stress [22] (see "Physical activity and exercise-induced oxidative stress" section), hormonal stress [23] , emotional stress and psychological burden [24] [25] [26] [27] as well as metabolic stress, e.g. in diabetes mellitus [28, 29] (see also below "Association between diabetes mellitus and carcinogenesis: diagnostic and therapeutic potential of cell-free nucleic acids" section) and hyperhomocysteinaemia [30, 31] amongst others, is associated with highly increased ROS production and insufficient repair capacity-both linked to oxidative damage of mitochondria and consequent mitochondrial dysfunction leading to the development of cardiovascular impairments [32] [33] [34] , neuro/degenerative pathologies [34] [35] [36] [37] , impaired healing [34] and malignant cell transformation [34, [38] [39] [40] [41] [42] . doi = 10.1007/s13167-020-00226-x id = cord-329313-tlbjw5kn author = Crilly, Philip title = A Systematic Review of Randomized Controlled Trials of Telehealth and Digital Technology Use by Community Pharmacists to Improve Public Health date = 2020-08-04 keywords = health; intervention; pharmacist; study summary = For this systematic review, we included the following studies that were: (1) randomized controlled trials (RCTs); (2) full articles published in peer-reviewed journals; (3) included a telehealth or digital technology element used for either interaction between a community pharmacist and customer/patient, such as telephone, email, online discussion boards, social media, smartphone mobile application, or for patient use alone as part of a community pharmacy intervention; and (4) reported public health interventions and outcomes. Further to the initial screening, abstracts and full articles were reviewed and removed if the primary objectives of the paper did not investigate the use of telehealth and digital technologies by community pharmacists for public health purposes and were not run as RCTs. A template was created in Excel, which both authors used to extract data including intervention variables (location of intervention and recruitment criteria, topic of delivered public health intervention, type of telecommunication or digital communication technology used, and duration of the intervention), participant variables (mean age, gender, and ethnicity), outcomes variables (e.g., quit smoking rates, reduction in weight, reduction in alcohol consumption, and treatment of a sexual transmitted disease). doi = 10.3390/pharmacy8030137 id = cord-314449-ukqux772 author = Curtis, L.T. title = Prevention of hospital-acquired infections: review of non-pharmacological interventions date = 2008-06-02 keywords = MRSA; hospital; infection; patient; study summary = Interventions such as proper hand and surface cleaning, better nutrition, sufficient numbers of nurses, better ventilator management, use of coated urinary and central venous catheters and use of high-efficiency particulate air (HEPA) filters have all been associated with significantly lower nosocomial infection rates. This review is not exhaustive and will not attempt mathematical data analysis but will examine recent research that examines non-pharmacological interventions for reducing HAIs. It will also include a brief description of the morbidity, mortality and medical costs associated with nosocomial infections, along with a brief discussion of the routes by which HAIs spread. Many terms were used in the literature searches including nosocomial, hospital acquired, MRSA (meticillin-resistant Staphylococcus aureus), staphyloccoccus, streptococcus, VRE (vancomycinresistant enterococcus), Clostridium difficile, legionella, klebsiella, tuberculosis, airborne infection, waterborne infection, hand washing, hospital cleaning, urinary catheters, central catheters, haemodialysis, ultraviolet light, HEPA (high-efficiency particulate air) filtration and many others. doi = 10.1016/j.jhin.2008.03.018 id = cord-004167-r2s0gks8 author = Cutts, Julia C. title = Pregnancy-specific malarial immunity and risk of malaria in pregnancy and adverse birth outcomes: a systematic review date = 2020-01-16 keywords = Plasmodium; VAR2CSA; antibody; study summary = Antibody responses to pregnancy-specific pRBC and VAR2CSA antigens, measured at delivery, were associated with placental malaria (9 studies) and may therefore represent markers of infection, rather than correlates of protection. To summarize, evidence from studies included in narrative terms suggests that whilst high avidity Abs and anti-adhesion Abs measured at delivery may be associated with protection from placental infection [65] and reduced placental parasitaemia [38] , respectively, total IgG responses to VAR2CSA antigens and pregnancy-specific pRBC are positively associated with the presence of placental malaria [34, 39, 64, [68] [69] [70] [71] [72] 76] . Overall, the majority of estimates included in this review, and studies included in narrative terms, indicate that when measured at delivery, antibody responses to pregnancy-specific pRBC and VAR2CSA antigens are associated with the presence of placental infection and may therefore represent markers of infection, rather than correlates of protection. doi = 10.1186/s12916-019-1467-6 id = cord-026392-cvb44v5v author = Dahlberg, Jørgen title = Barriers and challenges in the process of including critically ill patients in clinical studies date = 2020-06-08 keywords = ICU; patient; study summary = RESULTS: Among 279 eligible critically ill patients, 204 (73%) were omitted from the study due to challenges and barriers in the inclusion process. Previous studies have identified obstacles when performing research in critically ill patients at intensive care units (ICU) related to challenges in the recruitment process [1] [2] [3] [4] . The legislation and clinical practice vary across the world, and a prior PubMed search did not disclose any resent Scandinavian research covering the overall barriers and challenges in the process of including critically ill patients in clinical studies. The purpose of this study was to identify practical, medical, legal or ethical barriers and challenges in the process of including critically ill patients in the Norwegian Intensive Care Unit Dalteparin Effect (NORIDES) study. The study revealed that most critically ill patients at ICU were unable to provide written, informed consent for study participation. doi = 10.1186/s13049-020-00732-x id = cord-328720-o9h1vquo author = Davis, Cristina E. title = Breath analysis for respiratory infections date = 2020-09-18 keywords = breath; infection; study summary = Indeed, recruiting those with the same symptoms in the control groups, including noninfectious disease subjects, such as sarcoidosis patients in the case of breath sampling for tuberculosis, is an increasingly essential parameter in a study design. Breath studies to diagnose bacterial infections caused by Mycobacterium tuberculosis (Mtb) are more likely to succeed than any other approach due to the extensive groundwork done by the Belgian-Tanzanian group APOPO (Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling) who have evaluated the volatiles from tens of thousands of sputum samples using trained giant Gambian rats. Beccaria and colleagues conducted two studies evaluating the use of human breath collected and stored on thermal desorption tubes and analyzed by comprehensive gas chromatographyetime-of-flight mass spectrometry (GCÂGC-TOFMS) to diagnose active TB in subjects with confirmed Mtb infection. In this particular case, however, cells inoculated with just RSV did not yield a sufficient change to the volatile profile for accurate diagnoses, providing evidence that each respiratory viral infection may have to be independently evaluated for its ability to be detected directly in breath samples. doi = 10.1016/b978-0-12-819967-1.00021-9 id = cord-313616-81u4nidw author = Davis, G. S. title = Spatial and temporal analyses to investigate infectious disease transmission within healthcare settings date = 2014-04-30 keywords = GIS; HCAI; analysis; outbreak; study summary = The use of similar techniques to create hospital maps, on which infection data can be displayed and analysed, could increase understanding of local transmission and risk, 11 and provide rapid dissemination of information through visualization. A systematic review of the literature on spatiotemporal examination of infectious diseases in healthcare settings between January 1961 and June 2013 was conducted using the following search terms: infection (e.g. HCAI, nosocomial, etc.); healthcare settings (e.g. hospital, intensive care, etc.); and time/space (e.g. spaceetime, spatial epidemiology, etc.). Many of these studies examined outbreaks 15e22 and evaluations of intervention strategies, 23e25 while others attempted to identify factors associated with potential nosocomial transmission (i.e. healthcare worker carriage, 26, 27 direct contact with cases, 28, 29 inadequate cleaning of medical equipment 30, 31 and the physical layout of hospital utilities 32, 33 ). An outbreak of carbapenem-resistant Acinetobacter baumannii infection in a neonatal intensive care unit: investigation and control doi = 10.1016/j.jhin.2014.01.010 id = cord-005600-gsbbjb5y author = De Jonghe, B. title = Acquired neuromuscular disorders in critically ill patients: a systematic review date = 1998 keywords = CINMA; ICU; study summary = Two studies showed a clinically important increase (5 and 9 days, respectively) in duration of mechanical ventilation and a mortality twice as high in patients with critical illness neuromuscular abnormalities, compared to those without. Two studies showed a clinically important increase (5 and 9 days, respectively) in duration of mechanical ventilation and a mortality twice as high in patients with critical illness neuromuscular abnormalities, compared to those without. Conclusions: Prospective studies of ICU-acquired neuromuscular abnormalities include a small number of patients with various electrophysiologic findings but insufficiently reported clinical correlations. Conclusions: Prospective studies of ICU-acquired neuromuscular abnormalities include a small number of patients with various electrophysiologic findings but insufficiently reported clinical correlations. C.) independently: studies had to enroll critically ill adult patients presenting acquired peripheral nervous system and/or muscular and/or neuromuscular transmission abnormalities, described clinically and/or electrphysiologically and/or histologically, involving limbs and/or respiratory muscle, in prospective cohort studies. doi = 10.1007/s001340050757 id = cord-329723-74bhv8cr author = Debes, Jose D. title = COVID-19 and the liver: the perils of non-peer reviewed science in times of a pandemic date = 2020-04-10 keywords = study summary = title: COVID-19 and the liver: the perils of non-peer reviewed science in times of a pandemic receptor referencing a manuscript that involves single cell RNA sequencing performed on liver cells. A number of opinions and original contributions, all in highly respected journals, have made reference to that single study in order to scientifically support this hypothesis 1, 3-5 . This is concerning, as it suggests a willingness of authors to bypass stringently reviewed data in their rush to share scientific knowledge. However, when such studies involve data related to single cell RNA sequencing, particularly in hepatocytes which has been shown to be particularly difficult to isolate and sequence, the reader is blind to the details of the study and directly susceptible to the conclusions of the authors. Liver injury during highly pathogenic human coronavirus infections Liver injury in COVID-19: management and challenges Clinical Characteristics of Imported Cases of COVID-19 in Jiangsu Province: A Multicenter Descriptive Study doi = 10.1053/j.gastro.2020.04.007 id = cord-010018-gl8uuqej author = Del Borrello, Giovanni title = New insights into pediatric community‐acquired pneumonia gained from untargeted metabolomics: A preliminary study date = 2019-12-10 keywords = child; pneumonia; study summary = 3, 4 Although epidemiological research has repeatedly pointed out that the large majority of lower respiratory infection in pediatric patients are caused by viruses, 2 physicians often lack the tools to reliably discriminate between bacterial and viral etiology [5] [6] [7] and a large percentage of children presenting with respiratory symptoms and fever are ultimately administered antibiotics. To increase the specificity of our findings and reduce the role of confounding variables, three exclusion criteria were strictly applied, concerning: infants (ie, children under 1 year of age), to avoid any diagnostic overlap between pneumonia and bronchiolitis; children with a previous diagnosis of chronic disease (HIV, asthma, immunodeficiency, CHD), to reduce the pathophysiological heterogeneity between CAP cases; and children given any oral or injected antibiotic therapy in the 48 hours preceding enrollment, to avoid cases of partially treated pneumonia, as the related pathophysiological profile differs from that of a lung infection devoid of any treatment. doi = 10.1002/ppul.24602 id = cord-287957-diyz54qy author = Deriba, Berhanu Senbeta title = Patient Satisfaction and Associated Factors During COVID-19 Pandemic in North Shoa Health Care Facilities date = 2020-10-13 keywords = COVID-19; North; patient; study summary = title: Patient Satisfaction and Associated Factors During COVID-19 Pandemic in North Shoa Health Care Facilities Therefore, this study aimed to assess patient satisfaction and associated factors among chronic patients who had a follow-up in North Shoa healthcare facilities. Therefore, this study aimed to assess patient satisfaction and associated factors during the COVID-19 pandemic among chronic patients who had follow-up at public health facilities in the North Shoa Zone, Oromia region, Ethiopia. Patients who maintained and observed better social distancing at the registration place, waiting for the outpatient department, laboratory, and pharmacy services as a means of the COVID-19 prevention in the healthcare facilities were significantly associated with patient satisfaction. Availability of sign and direction indicators, availability of ordering drugs, social distancing status in the healthcare facility, availability of alcohol, and sanitizer for hand cleaning at the healthcare facility entrance to prevent and control COVID-19 were factors associated with the satisfaction of patients with chronic diseases. doi = 10.2147/ppa.s276254 id = cord-023713-daz2vokz author = Devereux, Graham title = Epidemiology of Asthma and Allergic Airway Diseases date = 2013-09-06 keywords = HRV; Health; States; United; asthma; child; prevalence; study; year summary = A systematic review and metaanalysis of the longitudinal studies relating maternal vitamin D status during pregnancy to childhood outcomes concluded that high maternal dietary vitamin D intake is associated with a reduced risk of children wheezing up to the age of 5 years (OR = 0.56; 95% CI, 0.42 to 0.73). The Dutch Prevention and Incidence of Asthma and Mite allergy (PIAMA) birth cohort study related symptom data prospectively collected annually from 3863 children up to the age of 8 years to land-use regression estimates of individual NO 2 , PM 2.5 , and soot exposures at their birth addresses. 327 A systematic review and meta-analysis of prospective birth cohort studies evaluating the effects of allergen (i.e., HDM or dietary) avoidance during pregnancy concluded that early-life allergen avoidance in isolation does not reduce the likelihood of asthma in children at age 5 years (OR = 1.22; 95% CI, 0.83 to 1.78). doi = 10.1016/b978-0-323-08593-9.00049-8 id = cord-272901-dsnbh4t1 author = Dew, Jeffrey title = Ten Years of Marriage and Cohabitation Research in the Journal of Family and Economic Issues date = 2020-10-22 keywords = family; marital; relationship; study summary = Thus, although no one aspect, theme, or methodology links the 36 studies I reviewed, many of them examined issues related to family structure and/or economic changes that have occurred over the past sixty years in the US and other nations. For the purposes of this review, I categorized a study as examining an underrepresented group if the sample was largely composed of individuals from race/ethnic minority groups, interracial couples, sexual minorities, low-income families, or from countries outside the United States. Many of the studies of the association between financial issues and relationship quality over the past three years have focused on the family stress model of economic pressure and marital distress (Conger et al. 1990 ), or simply "family stress model." Since its inception in 1990, many scholars have used this model to research the association between negative financial events, feelings of economic pressure, and marital quality. doi = 10.1007/s10834-020-09723-7 id = cord-334180-aqw9snt7 author = Doll, Julian title = Contrast-enhanced ultrasound for determining muscular perfusion after oral intake of L-citrulline, L-arginine, and galloylated epicatechines: A study protocol date = 2020-10-09 keywords = CEUS; arginine; muscle; study summary = Three commercial NO enhancing products including 300 mg of the specific green tea extract VASO6 and a combination of 8 g L-citrulline malate and 3 g L-arginine hydrochloride will be examined for their potential to increase muscular perfusion in 30-male athletes between 18 and 40 years and will be compared with a placebo. For this purpose, the following study will examine 3 different commonly used NO-boosting products via CEUS: 300 mg VASO6 8 g L-citrulline malate 3 g L-arginine hydrochloride After oral intake, changes of muscular microperfusion linked to resistance training will be quantified and the effects of supplementation will be compared with one another and with placebo in 30 healthy athletes. The objective of this placebo-controlled, randomized cross-over study is to assess the muscle perfusion increasing potential of 3 different commercial NO enhancing supplements in 30 healthy male athlete''s biceps muscle at rest and after exercising. doi = 10.1097/md.0000000000022318 id = cord-352040-zmkjine7 author = Dominski, Fábio Hech title = Psychological variables of CrossFit participants: a systematic review date = 2020-08-29 keywords = CrossFit; exercise; study; training summary = We included studies that investigated the following topics related to the psychology of CrossFit participants for the analysis: attention, activation, cohesion, cooperation, cognition, concentration, coping, feedback, flow-feeling, leadership, motivation, satisfaction, self-determination, sense of community, decision making, mental health, perfectionism, personality, mental training, and visualisation (related to participation), abandonment, addiction, aggression, anxiety, burnout, dependence, dropout, mood, body image, perception of competence, self-confidence, self-efficacy, self-esteem, depression, emotions, stress, reaction time (related to psychological effects of participating). Exercise psychology themes such as motivation, adherence, self-esteem, attention, well-being, body awareness, exercise addiction, effort, mood, anxiety, social identity, athletic identity, sense of community, enjoyment, personality, perception of body competence, satisfaction with body image, and mental health were identified. Due to the lack of studies on dropouts of CrossFit [17] , we point out the urgency of studies specifically on the motivational characteristics that lead the participants to dropout versus continue; this may improve the understanding of physical exercise behaviours related to high-intensity functional training modalities. doi = 10.1007/s11332-020-00685-9 id = cord-282280-5pggpbrq author = Doornekamp, Laura title = Determinants of Vaccination Uptake in Risk Populations: A Comprehensive Literature Review date = 2020-08-27 keywords = HCW; ICP; study; uptake; vaccination summary = The following concepts are used: (1) predisposing factors, including baseline characteristics of studied populations; (2) information factors, including information retrieved via media, social contacts and HCW; (3) awareness, of the infectious agent being present or a vaccine being available; (4) knowledge (either examined or self-evaluated), about the consequences of the infection, or about the efficacy and duration of protection of vaccination; (5a) perceived risk of the infection, which is divided into perceived severity of the disease and perceived susceptibility to get infected; (5b) perceived risk of vaccination, including vaccine-specific considerations such as fear of side-effects and trust in the effectiveness of the vaccine; (6) attitude, defined as a person''s disposition to respond favourably or unfavourably to vaccinations [14] , often reflected by a person''s general believes about vaccinations; (7) social influence, which can be social norms imposed by family, friends or religion, but also recommendations from a healthcare professional or tour guide; (8) self-efficacy, defined as beliefs in one''s own capacity to perform certain behaviour [15] ; (9) intention to behaviour, expressed by people before they perform the behaviour; (10) barriers and facilitators, that withhold individuals from or enable them to certain behaviour, such as time, costs, or accessibility. doi = 10.3390/vaccines8030480 id = cord-032623-32m3qko4 author = Durkin, Louisa title = When mycologists describe new species, not all relevant information is provided (clearly enough) date = 2020-09-10 keywords = author; description; specie; study; taxonomy summary = To assess whether fungal species descriptions are attuned to both the wants and needs of a target audience beyond taxonomists and the sign of the times, we explored 10 years'' worth of fungal species descriptions of extant mycological taxa in five major mycological journals (plus one botany journal for reference) for a range of factors pertaining to inter-and intra-scientific terms and concepts, science-demographical aspects, and illustrations and visualisations (Tables 1, 2; Suppl. Dark green -proportion of studies mentioning the word "ecology" or its variations; brown -proportion of studies giving a complete account of the taxonomic affiliation of the new species (family, order, and phylum); purple -proportion of studies with a macroscopic colour photo/illustration of the new species; pink -proportion of studies with macroscopic photos, that also indicate the size of the depicted object through a scale bar or a fiducial marker; light green -proportion of studies with an identification key; yellow -proportion of openly available papers for each year as assessed in 2020 B demographical and publication trends showing the average number of coauthors (dark green), departments (brown), countries (purple), continents (pink), and number of data visualizations (light green) over time. doi = 10.3897/mycokeys.72.56691 id = cord-022889-lv6fy6e6 author = Dávalos, Alberto title = Literature review of baseline information on non‐coding RNA (ncRNA) to support the risk assessment of ncRNA‐based genetically modified plants for food and feed date = 2019-08-07 keywords = Arabidopsis; Authority; EFSA; European; Food; Juliano; MIR2911; PCR; RNA; Safety; author; cell; document; effect; exogenous; figure; follow; human; miRNAs; plant; present; right; study; support summary = This report suggests that some plant ncRNAs (e.g miRNAs and siRNAs) show higher stability as compared to other ncRNAs due to peculiar chemical characteristics (2''‐O‐methylation at 3'' end).However, ingested or administered ncRNA must overcome many extracellular and cellular barriers to reach the intended target tissue or functional location in sufficient amount to exert any biological effect. Finally, the publications reporting the outcome of two EFSA procurements aiming respectively at investigating and summarising the state of knowledge on the mode-of-action of dsRNA and miRNA pathways, the potential for non-target gene regulation by dsRNA-derived siRNAs or miRNAs, the determination of siRNA pools in plant tissues and the importance of individual siRNAs for silencing 6 ; and reviewing relevant scientific information on RNA interference that could serve as baseline information for the environmental risk assessment of RNAi-based GM plants ) 7 were also used. doi = 10.2903/sp.efsa.2019.en-1688 id = cord-324981-teywszlm author = Eccles, Ron title = Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold date = 2010-08-10 keywords = Carrageenan; Iota; nasal; study; symptom summary = title: Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold METHODS: In a randomized, double-blind, placebo-controlled exploratory trial, 35 human subjects suffering from early symptoms of common cold received Iota-Carrageenan (0.12%) in a saline solution three times daily for 4 days, compared to placebo. The presented exploratory study was designed to determine the magnitude of any effect of Iota-Carrageenan nasal spray on the severity of common cold symptoms relative to placebo treatment. The current study was designed as a single centre, randomised, double-blind, parallel group, placebo-controlled comparative survey in subjects with early symptoms of common cold to assess the efficacy of a 0.12% Iota-Carrageenan nasal spray in the early treatment of natural colds. The results of this study indicate that the Iota Carrageenan nasal spray is a safe and effective treatment when taken within 48 hours of development of common cold symptoms. doi = 10.1186/1465-9921-11-108 id = cord-262345-hti1jjpn author = Eddy, Lucy H. title = The validity and reliability of observational assessment tools available to measure fundamental movement skills in school-age children: A systematic review date = 2020-08-25 keywords = FMS; MABC; Motor; TGMD; study summary = title: The validity and reliability of observational assessment tools available to measure fundamental movement skills in school-age children: A systematic review METHODS: A pre-search of ''fundamental movement skills'' OR ''fundamental motor skills'' in seven online databases (PubMed, Ovid MEDLINE, Ovid Embase, EBSCO CINAHL, EBSCO SPORTDiscus, Ovid PsycINFO and Web of Science) identified 24 assessment tools for school-aged children that: (i) assess FMS; (ii) measure actual motor competence and (iii) evaluate performance on a standard battery of tasks. The psychometric properties of observational assessments of fundamental movement skills for school children correlations to evaluate the concurrent validity between the MOT 4-6 and the KTK, with results showing moderate correlations for children aged 5-6 (mean r = .63), as was hypothesised prior to testing (r >. doi = 10.1371/journal.pone.0237919 id = cord-257244-gryp0khc author = Edwards, M. R. title = The potential of anti‐infectives and immunomodulators as therapies for asthma and asthma exacerbations date = 2017-08-10 keywords = antibiotic; asthma; respiratory; study summary = Despite these important associations, the use of antiinfectives (antibiotics, antivirals, antifungals, vaccines) that specifically target known pathogens, or drugs that are based on or exploit microbe-host receptor interactions (toll-like receptor agonists, bacterial lysates) or are immunomodulators (vitamin D), and/or may work in part by altering our associated microbiology (probiotics) are, with the exception of severe asthma, seldom considered in asthma treatment, prevention and guidelines. Overall, antibiotic use is associated with asthma risk rather than protection at most stages of human development, including pregnancy, 10, 11 early life 12 and childhood, 13 although why this is so is a subject widely debated. 10 In retrospective studies, the association between antibiotic use and increased risk of asthma or wheezing in children is further confused due to the potential of reverse causation. Inhibiting virus replication through interfering with viral enzymes active within cells poses additional problems in drug discovery; however, several useful inhibitors for respiratory tract viruses have found their way into phase I/II clinical trials. doi = 10.1111/all.13257 id = cord-352364-yj31uwiu author = El Morr, Christo title = Effectiveness of ICT-based intimate partner violence interventions: a systematic review date = 2020-09-07 keywords = ICT; IPV; study; violence; woman summary = We reviewed the available evidence on the use of ICT-based interventions to address intimate partner violence (IPV), evaluating the effectiveness, acceptability, and suitability of ICT for addressing different aspects of the problem (e.g., awareness, screening, prevention, treatment, mental health). Key search terms included women, violence, domestic violence, intimate partner violence, information, communication technology, ICT, technology, email, mobile, phone, digital, ehealth, web, computer, online, and computerized. RESULTS: Twenty-five studies addressing screening and disclosure, IPV prevention, ICT suitability, support and women''s mental health were identified. Recent systematic reviews showed that the efficacy of ICT-based mobile apps for health (mHealth) is still limited, as research in the field lacks long-term studies and existing evidences of impact are inconsistent [52] . Longitudinal impacts of an online safety and health intervention for women experiencing intimate partner violence: randomized controlled trial ICT-based interventions for women experiencing intimate partner violence: research needs in usability and mental health doi = 10.1186/s12889-020-09408-8 id = cord-349474-pprxwij6 author = Elshami, Wiam title = The radiology workforce’s response to the COVID-19 pandemic in the Middle East, North Africa and India date = 2020-09-23 keywords = COVID-19; fear; pandemic; study summary = Introduction This study aimed to investigate the response of the radiology workforce to the impact of the coronavirus disease 2019 (COVID-19) pandemic on professional practice in India and eight other Middle Eastern and North African countries. The survey collected information related to the following themes: (1) demographic characteristics, (2) the impact of COVID-19 on radiology practice, and (3) fear and (4) anxiety emanating from the global pandemic. The respondents reported experiences of work-related stress (42.9%), high COVID-19 fear score (83.3% ) and anxiety (10%) during the study period. The respondents reported experiences of work-related stress (42.9%), high COVID-19 fear score (83.3% ) and anxiety (10%) during the study period. Moreover, our ability to assess the impact of the COVID-19 pandemic on radiology practices and associated factors, such as fear and anxiety, among the RWF provided more insight into the psychological needs of medical workers to continue providing quality service. doi = 10.1016/j.radi.2020.09.016 id = cord-287607-d3k26aar author = Emamaullee, Juliet title = Rapid Adaptation of a Surgical Research Unit to Conduct Clinical Trials during the Coronavirus-19 Pandemic. date = 2020-06-29 keywords = COVID-19; clinical; study summary = Ongoing ''Stay at Home'' orders and institutional policies mandating ''Work from Home'' for non-essential employees, which includes most research personnel, have impacted the ability to implement and conduct clinical studies. At the same time, plans were implemented to continue collection of data to achieve endpoints, safely enroll and follow participants in studies offering potential benefit, and quickly implement new COVID-19 clinical trials. These efforts were directed at the identification of the following areas that would require modification: minimization of direct patient care for routine study activities, logistics of research staff working from home, and study-specific protocol deviations, enrollment pauses, and remote site monitoring visits (Figure 3) . Sponsors were highly responsive, providing amendments to allow for study adjustments, including suspension of enrollment when appropriate for a specific study, protocol modifications to allow for remote follow up and designed for participant safety as well as to assure that data collection to achieve endpoints could be collected, and implementation of remote monitoring, etc. doi = 10.1016/j.jss.2020.06.049 id = cord-321836-rbqqgekw author = Everest, T. title = Determination of agricultural land suitability with a multiple-criteria decision-making method in Northwestern Turkey date = 2020-08-06 keywords = AHP; GIS; land; study; suitability summary = Land use capability classes, soil depth, erosion risk and other soil properties (limiting factors) were obtained from the soil map, while slope, elevation and aspect were obtained from the Shuttle Radar Topography Mission data. AHP is one of the multiple-criteria decision-making methods used for the assessment and analysis of land use suitability. In this study, the aim was to determine agricultural land suitability by using the AHP method, to compare with current land use in 2019 and to produce real data for land owners and decision makers about how to evaluate the land of Lapseki district in Çanakkale, northwestern (NW) Turkey. (2018) determined agricultural land suitability based on some soil characteristics and slope conditions and they produced a sustainable agricultural support plan for their study area. This study determined the agricultural land suitability by using basic soil properties, DEM data, GIS and AHP methods. doi = 10.1007/s13762-020-02869-9 id = cord-012980-oaie2i8m author = FRIEDMAN, MARVIN A. title = A Lifetime Oncogenicity Study in Rats with Acrylamide date = 1995-08-17 keywords = Fischer; Johnson; dose; rat; study summary = doi = 10.1093/toxsci/27.1.95 id = cord-001989-6gi3o5mu author = Faber, Timor title = Meta-analyses including non-randomized studies of therapeutic interventions: a methodological review date = 2016-03-22 keywords = NRSI; analysis; meta; review; study; systematic summary = METHODS: For this methodological review, we searched MEDLINE via PubMed, from January 1, 2013 to December 31, 2013 for meta-analyses including at least one non-randomized study evaluating therapeutic interventions. CONCLUSIONS: Some key methodological components of the systematic review process—search for grey literature, description of the type of NRSI included, assessment of risk of confounding bias and reporting of whether crude or adjusted estimates were combined—are not adequately carried out or reported in meta-analyses including NRSI. Therefore, an increasing number of systematic reviews and meta-analyses are including data from non-randomized studies to assess therapeutic interventions. To illustrate: a metaanalysis that investigated the association of the use of statins and risk of cancer would was considered a therapeutic evaluation if the authors planned to include RCTs. Individual patient data meta-analyses were also excluded, as were non-randomized studies that conducted a meta-analysis of the literature as secondary analysis. doi = 10.1186/s12874-016-0136-0 id = cord-280373-xhvhep84 author = Faust, A. title = Challenges and proposed solutions in making clinical research on COVID-19 ethical. A status quo analysis across German research ethics committees date = 2020-08-14 keywords = COVID-19; challenge; study summary = Methods: We conducted a qualitative survey across all 52 German RECs on the challenges and potential solutions with reviewing proposals for COVID-19 studies. For the review of these proposals the RECs indicated a broad spectrum of challenges regarding i) social value (e.g. lack of coordination), ii) scientific validity (e.g. provisional study planning), iii) favourable risk-benefit ratio (e.g. difficult benefit assessment), iv) informed consent (e.g. strict isolation measures), v) independent review (e.g. lack of time), vi) fair selection of trial participants (e.g. inclusion of vulnerable groups), and vii) respect for study participants (e.g. data security). The qualitative responses from the 22 RECs on perceived challenges and proposed solutions were all grouped under one or more of seven principles of the employed research ethics framework: social value, scientific validity, informed consent, respect for participants, independent review, favourable risk-benefit analysis and fair participant selection. doi = 10.1101/2020.08.11.20168773 id = cord-348994-ly2fop7d author = Faustini, Annunziata title = Attributable Risk to Assess the Health Impact of Air Pollution: Advances, Controversies, State of the Art and Future Needs date = 2020-06-23 keywords = Air; Pollution; effect; exposure; study summary = It also summarizes the ongoing discussion about the designs and methods for assessing the air pollution impact with particular attention to improvements due to spatio-temporal analysis and other new approaches, such as studying short term effects in cohorts, and the still discussed methods of predicting the values of attributable risk (AR). The most important problems with these studies were recognized by the researchers themselves, i.e., (1) not having studied other factors potentially responsible for the effects, including air pollutants other than particulate matter (PM), (2) not having individual measurements of exposure, which could prefigure exposure measurement errors, (3) having measured mortality that was premature only by a few days, which is an effect of limited public-health impact, (4) having used different methods to study this association in different cities. doi = 10.3390/ijerph17124512 id = cord-306391-g7dhwogk author = Fernando, Shannon M. title = Diagnosis of ventilator-associated pneumonia in critically ill adult patients—a systematic review and meta-analysis date = 2020-04-18 keywords = VAP; study summary = We conducted a systematic review and meta-analysis to evaluate diagnostic performance (including sensitivity and specificity) of these signs and tests, compared with either histopathology of lung tissue, or quantitative BAL cultures as reference standards. We included studies meeting the following criteria: 1) ≥ 90% adult patients (≥ 16 years); 2) conducted in the ICU; 3) included patients with ≥ 48 h of invasive mechanical ventilation; and 4) evaluated one or more of the following characteristics: fever (defined as body temperature ≥ 38 degrees Celsius), purulent secretions, leukocytosis (any threshold), chest radiography, gram stain, and/or culture from ETA (≥ 10 5 colony-forming units [CFU]/mL), PSB (≥ 10 3 CFU/mL), BAL (≥ 10 4 CFU/mL), or CPIS for diagnosis of VAP. In this meta-analysis, we found that physical examination findings (fever, purulent secretions), chest radiography, endotracheal aspirate cultures, bronchoscopic cultures, and Clinical Pulmonary Infection Score (CPIS) have poor accuracy for diagnosing ventilator-associated pneumonia. doi = 10.1007/s00134-020-06036-z id = cord-346327-dgpkiqgu author = Ferriss, J. Stuart title = Systematic Review of Intraoperative Assessment Tools in Minimally Invasive Gynecologic Surgery date = 2020-10-18 keywords = study; tool summary = Objective : To collect, summarize, and evaluate the currently available intraoperative rating tools used in abdominal minimally invasive gynecologic surgery (MIGS). Conclusions Procedure specific intraoperative assessment tools for MIGS cases are more 37 thoroughly evaluated compared to global tools; however, poor-quality studies and borderline 38 reliability limit their use. Conclusions Procedure specific intraoperative assessment tools for MIGS cases are more 37 thoroughly evaluated compared to global tools; however, poor-quality studies and borderline 38 reliability limit their use. Well designed, controlled studies evaluating the effectiveness of 39 intraoperative assessment tools in MIGS are needed. Articles describing the use of an evaluation tool focused on a minimally invasive 81 abdominal gynecologic procedure in the intraoperative or perioperative setting were included. Four of the studies 106 used a global assessment tool, and the remaining 6 used a tool evaluated during a specific 107 minimally invasive procedure: salpingectomy (2), supra-cervical hysterectomy, total 108 laparoscopic hysterectomy (2), and robotic hysterectomy. doi = 10.1016/j.jmig.2020.10.007 id = cord-258087-93yfs7ve author = Flores, Carlos title = A quality assessment of genetic association studies supporting susceptibility and outcome in acute lung injury date = 2008-10-25 keywords = ALI; ARDS; acute; study summary = CONCLUSIONS: Although the quality of association studies seems to have improved over the years, more and better designed studies, including the replication of previous findings, with larger sample sizes extended to population groups other than those of European descent, are needed for identifying firm genetic modifiers of ALI. This quality assessment of genetic association studies with positive findings in susceptibility or outcome of ALI and ARDS identified a total of 29 articles and 16 genes. ACE, angiotensin-converting enzyme; ALI, acute lung injury; ARDS, acute respiratory distress syndrome; CAP, community-acquired pneumonia; CXCL2, chemokine CXC motif ligand 2; F5, coagulation factor V; IL-6, interleukin-6; IL-10, interleukin-10; MBL2, mannose-binding lectin-2; MIF, macrophage migration inhibitory factor; MV, mechanical ventilation; MYLK, myosin light-chain kinase; NFKB1, nuclear factor kappa light polypeptide gene enhancer in B cells; NFKBIA, nuclear factor kappa light polypeptide gene enhancer in B cells inhibitor alpha; NRF2, nuclear factor erythroid-derived 2 factor; PBEF, pre-B cell-enhancing factor; PLAU, plasminogen activator urokinase; SARS, severe acute respiratory syndrome; SFTPB, surfactant pulmonaryassociated protein B; SIRS, systemic inflammatory response syndrome; SNP, single-nucleotide polymorphism; TNF, tumor necrosis factor; TR, tandem repeat (polymorphism); VEGF, vascular endothelial growth factor. Positive genetic association studies with acute lung injury/acute respiratory distress syndrome susceptibility and/or outcome (by year of publication) doi = 10.1186/cc7098 id = cord-253525-r6ocr18h author = Fontbonne, Alain title = Small animal reproduction: Scientific facts versus dogmas or unverified beliefs date = 2020-03-11 keywords = SAR; bitch; cat; dog; study summary = Through examples, this article reviews the main causes that may sometimes challenge a veterinary practitioner faced with a dog or a cat presenting reproductive problems. This problem may result from the fact that there are still physiological processes that remain unclear, but also that some common beliefs are based on old studies that have not been repeated or verifiedIn addition, to make it more challenging to seek for the information, there are unverifiedaffirmations,unclear nomenclature, clinical conditions which have not been standardized in the literature, clinical conditions mostly described through case reports, lack of studies on specific topics, areas of small animal reproduction that have been neglected by researchers, contradictory data or even studies that lack objectivity. Concerning the belief that an early neutering lowers significantly the risk for a bitch to develop mammary tumours later in her life, it is based on a study published in 1969 which has not been repeated since then [19] . doi = 10.1016/j.theriogenology.2020.03.014 id = cord-292853-xihpfidg author = Ford, Julian D. title = Social, cultural, and other diversity issues in the traumatic stress field date = 2015-08-07 keywords = American; Cross; PTSD; Red; States; United; person; sexual; stress; study; traumatic; woman summary = A social-ecological framework is used to differentiate the impact of exposure to traumatic stressors and the development of (or resistance to) PTSD, based on the individual''s or group''s (i) personal, unique physical characteristics, including skin color, racial background, gender, and sexual orientation; and (ii) family, ethnocultural, and community membership, including majority or minority group status, religious beliefs and practices, socioeconomic resources, and political and civic affiliations. Depending on Social, cultural, and other diversity issues in the traumatic stress field 505 their cultural background and its traditions and beliefs, individuals may also have "multiple vulnerability status"-that is, to be members of more than one group or to have characteristic that cause them to be even more susceptible to discrimination or victimization (i.e., adolescent black male in the United States; a baby born with physical or developmental disabilities in a culture that endorses selective resources to the ablebodied; a gay man or lesbian woman of color in a highly homophobic and racist society). doi = 10.1016/b978-0-12-801288-8.00011-x id = cord-023913-pnjhi8cu author = Foreman, Stephen title = Broader Considerations of Medical and Dental Data Integration date = 2011-10-08 keywords = Association; EHR; Fig; Health; Institute; Medicaid; Medicare; National; clinical; cost; dental; disease; medical; oral; patient; periodontal; school; study; system summary = So while there has been no shortage of effort paid to improving Medicare, the one common theme in all of the recent initiatives is that dental care has been conspicuously 1 A new study by Hedlund, Jeffcoat, Genco and Tanna funded by CIGNA of patients with Type II diabetes and periodontal disease found that medical costs of patients who received maintenance therapy were $2483.51 per year lower than patients who did not. Examples of integrated care models do exist, such as that presented by (Heuer 2007 ) involving school-linked and school-based clinics with an "innovative health infrastructure." According to Heuer, "Neighborhood Outreach Action for Health (NOAH)" is staffed by two nurse practitioners and a part-time physician to provide "primary medical services to more than 3,200 uninsured patients each year" in Scottsdale, Arizona. doi = 10.1007/978-1-4471-2185-5_4 id = cord-353876-pb4of7s9 author = Fortaleza, Carlos Magno Castelo Branco title = Evidence, rationality, and ignorance: Agnotological issues in COVID-19 science date = 2020-09-21 keywords = COVID-19; evidence; scientific; study summary = Researchers, public health authorities, and healthcare workers should be equipped to identify such agnotological strategies, distinguish them from scientific fraud, and avoid drawing misleading inferences based on an irrational adherence to hypotheses and a lack of criticism of implausible results. It may surprise an orthodox practitioner of evidence-based medicine (EBM) to learn that, in accordance with a tradition that dates back to David Hume (1711-1776), Popper rejected induction, which refers to the notion that a series of observations and experiments (i.e., evidence) allows one to draw inferences about general scientific laws or generate "recommendations." Popper''s views can be summarized as follows: "there are several sources of knowledge, but science progresses blindly toward the truth rather by eliminating errors (by continuous criticism and empirical research) than from gathering cumulative evidences." Despite major ideological differences, some of the greatest 20 th century philosophers of science (Popper 2 , Kuhn 3 , Lakatos 4 , and Feyerabend 5 ) prioritized rationality over the accumulation of evidence. doi = 10.1590/0037-8682-0475-2020 id = cord-016472-jj7fqcen author = Freudenberg, Nicholas title = Health Research Behind Bars: A Brief Guide to Research in Jails and Prisons date = 2007 keywords = HIV; correctional; health; research; study summary = For health researchers and their collaborators, the audience for this chapter, correctional facilities offer several unique advantages: a population at high risk of many health problems including infectious and chronic diseases, substance abuse, and mental health problems; social and physical environments that can enhance or impede well-being; a setting that is a focal point for the class, racial/ethnic, and gender differences that divide the United States; a site where health and mental health services and prevention programs are offered and can be evaluated; a controlled environment for administration of treatments such as directly observed therapy for tuberculosis; and a stopping point in the cycle of incarceration and reentry that so profoundly affects community well-being. doi = 10.1007/978-0-387-71695-4_24 id = cord-301805-sb0ij8k7 author = Fuentes, Blanca title = Glycemic variability: prognostic impact on acute ischemic stroke and the impact of corrective treatment for hyperglycemia. The GLIAS-III translational study date = 2020-11-04 keywords = glucose; patient; study summary = METHODS: This translational study consists of two studies conducted in parallel: The first study is an observational, multicenter, prospective clinical study in which 340 patients with acute IS will be subcutaneously implanted a sensor to continuously monitor blood glucose levels for 96 h. DISCUSSION: The GLIAS-III study will be the first translational approach analyzing the prognostic influence of GV, evaluated by the use of subcutaneous glucose monitors, in acute stroke. We hypothesized that GV, assessable by means of continuous subcutaneous monitoring devices, could act as a powerful prognostic predictor of mortality, possibly higher than assessment of mean or maximum blood glucose levels and that the different treatment regimens used in routine clinical practice could modify glycemic variability. No laboratory data other than HbA1c will be collected for Discussion: The GLIAS-III study will be the first translational approach analyzing the prognostic influence of GV, evaluated by the use of subcutaneous glucose monitors, in acute stroke. doi = 10.1186/s12967-020-02586-4 id = cord-216972-migs9rxb author = Garaialde, Diego title = Quantifying the Impact of Making and Breaking Interface Habits date = 2020-05-14 keywords = habit; interface; response; study summary = Through a forced choice lab study task (n=19) and in the wild deployment (n=18) of a notificationdialog experiment on smartphones, we show that people become more accurate and faster at option selection as they develop an interface habit. The contribution of the current paper comes from providing quantitative evidence of how the process of forming and disrupting habits affects user performance in a forced choice interaction task, similar to those seen in notification dialogs or alert boxes. The current research contributes key insight on fundamental user behaviours by quantifying how the process of habit formation and disruption through design affect the speed and accuracy of interactions. The experimental evidence of study 1 shows that, like other habits, allowing participants to form interface habits leads to significant gains in performance, as users became both more accurate and quicker at selecting the desired option. doi = nan id = cord-316666-qif1k62t author = Ghati, Nirmal title = Atorvastatin and Aspirin as Adjuvant Therapy in Patients with SARS-CoV-2 Infection: A structured summary of a study protocol for a randomised controlled trial date = 2020-10-30 keywords = aspirin; covid-19; patient; study summary = title: Atorvastatin and Aspirin as Adjuvant Therapy in Patients with SARS-CoV-2 Infection: A structured summary of a study protocol for a randomised controlled trial Patients with a critical illness (WHO clinical improvement ordinal score > 5), documented significant liver disease/dysfunction (aspartate transaminase [AST] / alanine aminotransferase [ALT] > 240), myopathy and rhabdomyolysis (creatine phosphokinase [CPK] > 5x normal), allergy or intolerance to statins or aspirin, prior statin or aspirin use within 30 days, history of active gastrointestinal bleeding in past three months, coagulopathy, thrombocytopenia (platelet count < 100000/ dl), pregnancy, active breastfeeding, or inability to take oral or nasogastric medications will be excluded. INTERVENTION AND COMPARATOR: In this study, the benefit and safety of atorvastatin (statin) and/or aspirin as adjuvant therapy will be compared with the control group receiving usual care for management of COVID-19. doi = 10.1186/s13063-020-04840-y id = cord-102474-fmq98aa8 author = Gooding, K. M. title = Prognostic Imaging Biomarkers for Diabetic Kidney Disease (iBEAt): Study protocol date = 2020-01-16 keywords = DKD; MRI; biomarker; study summary = Embedded within iBEAT are ancillary substudies that will (1) validate imaging biomarkers against renal histopathology; (2) validate MRI based renal blood flow against water-labelled positron-emission tomography (PET); (3) develop machine-learning methods for automated processing of renal MRI images; (4) examine longitudinal changes in imaging biomarkers; (5) examine whether the glycocalyx, microvascular function and structure are associated with imaging biomarkers and eGFR decline; (6) a pilot study to examine whether the findings in T2D can be extrapolated to type 1 diabetes. The key hypotheses are that (1) imaging-based biomarkers of DKD provide additional information on the pathogenesis and histological and clinical heterogeneity of DKD compared to biomarkers sourced from samples or physical exams, and (2) that changes in imaging biomarkers precede increases in albuminuria and decline in kidney function as measured by eGFR. doi = 10.1101/2020.01.13.20017228 id = cord-011335-pamcpi8n author = Govindan, Vedavalli title = Cerebral venous volume changes and pressure autoregulation in critically ill infants date = 2020-03-10 keywords = cerebral; pressure; study summary = STUDY DESIGN: In a prospective study of newborns undergoing positive-pressure ventilation, we calculated coherence between continuous mean arterial pressure (MAP) and cerebral near-infrared spectroscopy hemoglobin difference (HbD). For this study, our goals were to evaluate the association between cerebral venous volume changes at the ventilator frequency on the development of (1) cerebral pressure passivity, and (2) brain injury, in newborn infants undergoing intensive care. The study population included infants with three broad categories of illness, all known to be at significant risk of brain injury, namely, term/ near-term infants with either perinatal hypoxic-ischemic encephalopathy (HIE) or congenital heart disease (CHD), as well as preterm infants (<37 weeks of gestational age (GA)). In this study, we identified a significant relationship between the magnitude of fluctuations in CBV associated with positive-pressure ventilation, and the presence of cerebral pressure passivity, in a population of critically ill newborn infants. doi = 10.1038/s41372-020-0626-0 id = cord-333340-ekok0mp5 author = Graf, Erin H. title = Appropriate Use and Future Directions of Molecular Diagnostic Testing date = 2020-02-06 keywords = clinical; panel; patient; study; testing summary = PURPOSE OF REVIEW: Major technologic advances in two main areas of molecular infectious disease diagnostics have resulted in accelerated adoption or ordering, outpacing implementation, and clinical utility studies. More studies are needed to assess their prospective impacts on patient management and antimicrobial stewardship efforts as the future state of infectious disease diagnostics will see continued expansion of these technologic advances. This review will highlight recent studies developing and applying emerging molecular infectious disease technologies and touch on limited published data on clinical utility and stewardship approaches. Ideally, we would evaluate all of these approaches via randomized controlled trials comparing patient outcomes between conventional microbiologic testing and testing including a syndromic panel; however, very limited studies addressing this have been published [8] . One of the only randomized controlled trials also found no difference in antibiotic usage, including duration, between adults tested via syndromic panel at the point-of-care compared to patients receiving conventional testing in a hospital emergency department and inpatient unit [15] . doi = 10.1007/s11908-020-0714-5 id = cord-292544-m7jyydf1 author = Grau-Pujol, Berta title = Pre-exposure prophylaxis with hydroxychloroquine for high-risk healthcare workers during the COVID-19 pandemic: A structured summary of a study protocol for a multicentre, double-blind randomized controlled trial date = 2020-07-29 keywords = COVID-19; Hospital; SARS; study summary = OBJECTIVES: The aim of this study is to assess the efficacy of the use of pre-exposure prophylaxis (PrEP) with hydroxychloroquine against placebo in healthcare workers with high risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in reducing their risk of coronavirus disease 2019 (COVID-19) disease during an epidemic period. As secondary endpoints, we will obtain: i) the SARS-CoV-2 seroconversion in the PrEP group compared to placebo during the 6 months of follow-up in healthcare workers with negative serology at day 0; ii) the occurrence of any adverse event related with hydroxychloroquine treatment; iii) the incidence of SARS-CoV-2 infection and COVID-19 among healthcare workers in the non-PrEP group, among the total of healthcare workers included in the non-PrEP group during the study period; iv) the risk ratio for the different clinical, analytical and microbiological conditions to develop COVID-19; v) a repository of serum samples obtained from healthcare workers confirmed COVID-19 cases for future research on blood markers to predict SARS-CoV-2 infection. doi = 10.1186/s13063-020-04621-7 id = cord-022082-1dq623oe author = Greaves, Peter title = Respiratory Tract date = 2007-09-28 keywords = BALT; Clara; cell; drug; epithelium; lung; mouse; nasal; pulmonary; rat; respiratory; study summary = In the case of tulobuterol, a 32-adrenergic receptor agonist, it was argued that the nasal inflammation induced in rats in a one month inhalation toxicity study was the result of a particularly high exposure of the nasal epithelium to drug, not representative of the likely human exposure to tulobuterol by inhalation, where little or no nasal exposure would occur.^^ RP73401 [3cyclopentyloxy)-Ar-(3,5-dichloro-4-pyridy)-4-methoxybenzamide], a novel type IV phosphodiesterase inhibitor which was being developed for the treatment of asthma and rheumatoid arthritis, was also reported to produce degeneration of the olfactory epithelium in rats but neither dogs nor mice after single and repeated oral doses and by inhalation.^^ Histologically, the olfactory epithelium showed necrosis of the superflcial epithelial layers including the sustentacular and sensory cells, with sparing of the basal cell layer. doi = 10.1016/b978-044452771-4/50007-9 id = cord-320172-qw47pf9r author = Greaves, Peter title = VII Digestive System 1 date = 2000-12-31 keywords = Paneth; Peyer; agent; cell; change; drug; effect; gastric; gland; hyperplasia; increase; intestinal; man; mouse; mucosa; rat; salivary; small; study summary = In common with other changes induced in the digestive tract of rats and cynomolgus monkeys by the administration of recombinant human epidermal growth factor, the tongue showed squamous epithelial hyperplasia characterised by a uniform increase in the thickness of the squamous epithelium in both species (Breider et al., 1996; Reindel et al., 1996) . Detailed study of hypertrophy, protein synthesis, and intracellular cAMP activity in the salivary glands of rats treated for 10 days with isoprenaline (isoproterenol), a series of β-adrenergic receptor agonists and the phosphodiesterase inhibitors, theophylline and caffeine, showed that similar effects occurred with all agents although differences in the degree of hypertrophy, the nature of pro-tein and glycoprotein synthesis and Golgi membrane enzyme activity were recorded (Wells and Humphreys-Beher, 1985) . Studies in the rat have shown that diffuse atrophy of the gastric glands characterised by a decrease in the number and size of parietal, chief and mucous cells occurs transiently following truncal vagotomy but histological features return to normal by about 1 month after surgery (Nakamura, 1985) . doi = 10.1016/b978-044450514-9/50007-3 id = cord-279748-ycgpqs89 author = Gremi, Téa title = COVID-19 studies registration worldwide for prospective studies with a specific focus on the fast-tracking of French ethic procedures date = 2020-06-30 keywords = study summary = key: cord-279748-ycgpqs89 authors: Gremi, Téa; Ginesy, Éric; Payen, Didier; Lefrant, Jean-Yves; Marin, Benoît title: COVID-19 studies registration worldwide for prospective studies with a specific focus on the fast-tracking of French ethic procedures date: 2020-06-30 journal: Anaesth Crit Care Pain Med DOI: 10.1016/j.accpm.2020.06.010 sha: doc_id: 279748 cord_uid: ycgpqs89 nan interventional, 899 (40%) observational, 37 not classified). Figure 1 shows the number of studies registered per country; 1289 (57%) studies are still recruiting and 138 were declared completed (6%). USA, China and France performed more than half of the studies worldwide (1202 studies (53%)). French legal approach to clinical research Ordonnance n° 2020-460 du 22 avril 2020 portant diverses mesures prises pour faire face à l''épidémie de covid-19 Notre ambition pour les industries de santé, 8ème Conseil stratégique des industries de santé (CSIS) doi = 10.1016/j.accpm.2020.06.010 id = cord-015910-d9gxew91 author = Grimble, Robert F. title = The Interaction Between Nutrition and Inflammatory Stress Throughout the Life Cycle date = 2005 keywords = GSH; IL-6; TNF; cytokine; effect; inflammatory; production; response; study summary = Binding of the transcription factors is implicated in activation of a wide range of genes associated with inflammation and the immune response, including those encoding cytokines, cytokine receptors, cell adhesion molecules, acute-phase proteins, and growth factors (Schreck, Rieber, & Baeurerle, 1991) (Fig. 4 ) . While inflammation may be exerting deleterious effects most obviously in patients, people on the borderline of health and disease living in the general population Table 4 Nutrients Commonly Used in Immunonutrient Supplements and Their Potential Mode of Action • n-3 polyunsaturated fatty acids: act as anti-inflammatory agents and reverse immunosuppression • Sulfur amino acids and their precursors: enhance antioxidant status via GSH synthesis • Glutamine: nutrient for immune cells, improves gut barrier function, precursor for GSH • Arginine: stimulates nitric oxide and growth hormone production, improves helper T-cell numbers • Nucleotides: RNA and DNA precursors, improve T-cell function may also require nutritional modulation of ongoing inflammatory processes. doi = 10.1385/1-59259-952-4:387 id = cord-343844-xe9tdjrm author = Guaiana, Giuseppe title = A Systematic Review of the Use of Telepsychiatry in Depression date = 2020-10-10 keywords = study summary = This systematic review explores the literature on the use of televideo to diagnose and treat MDD, particularly acceptability and patient satisfaction, efficacy, and cost-effectiveness. Study eligibility criteria included: MDD as the condition of interest, use of televideo technology, randomized controlled trials (RCTs), Adult (18 years or older) population, any clinical setting, and any healthcare professional providing care. The goal of this review is to provide a systematic review on telepsychiatry in MDD and assess its face validity, acceptability by patients and cost-effectiveness compared to in-person care, so that providers will be better equipped to understand its advantages and potential drawbacks. The authors'' original intention, as specified in the protocol published on PROSPERO, was to conduct a meta-analysis of the use of telepsychiatry (meaning care provided by a psychiatrist using televideo) in depression for assessment and treatment looking at RCT only. doi = 10.1007/s10597-020-00724-2 id = cord-336131-7xqi1mnx author = Gupta, Manika title = Preclinical Studies of MSC-Derived Extracellular Vesicles to Treat or Prevent Graft Versus Host Disease: a Systematic Review of the Literature date = 2020-11-07 keywords = GVHD; MSC; study summary = The use of mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) appears promising and a systematic review of preclinical studies is needed to accelerate the design of translational studies. In brief, eligible studies included the treatment or prevention of GVHD in animal models and the use of MSC-EVs. Study design and outcome data were extracted and reporting was evaluated using the SYRCLE tool to identify potential bias. There is a need to perform a systematic review to identify the extent to which MSC-EVs are effective in treating or preventing GVHD and to inform potential future preclinical and clinical studies regarding the optimal method of isolating and administering EVs, including aspects such as dosing and route of administration and schedules of EV treatment. Extracellular vesicles released from human umbilical cord-derived mesenchymal stromal cells prevent lifethreatening acute graft-versus-host disease in a mouse model of allogeneic hematopoietic stem cell transplantation doi = 10.1007/s12015-020-10058-x id = cord-000285-7p3b6tyf author = HARTERT, Tina V. title = The Tennessee Children''s Respiratory Initiative: Objectives, design and recruitment results of a prospective cohort study investigating infant viral respiratory illness and the development of asthma and allergic diseases date = 2010-04-08 keywords = asthma; infant; respiratory; study summary = The primary goals of the study are: (i) to investigate both the acute and the long-term health consequences of varying severity and aetiology of clinically significant viral respiratory tract infections on the outcomes of allergic rhinitis (AR) and early childhood asthma; and (ii) to identify the potentially modifiable factors that define children who are at greatest risk of developing asthma following infant respiratory viral infection. Thus, we designed the prospective TCRI to establish a base for the evaluation of both the risks and benefits of documented significant infant viral respiratory infection of varying severity and aetiology and other environmental exposures on childhood atopy outcomes and to establish a biospecimen repository for analyses including biomarker testing and genotyping. The TCRI is a prospective cohort of mother-infant dyads enrolled in a longitudinal investigation of the relationship of infant viral respiratory infection severity and aetiology and the interaction of other risk factors on the development of childhood asthma and allergic diseases. doi = 10.1111/j.1440-1843.2010.01743.x id = cord-266031-tlrsco40 author = Haghani, Milad title = Covid-19 pandemic and the unprecedented mobilisation of scholarly efforts prompted by a health crisis: Scientometric comparisons across SARS, MERS and 2019-nCoV literature date = 2020-09-21 keywords = Covid-19; MERS; SARS; literature; study summary = To compare the scientometric aspects of the studies on SARS, MERS and Covid-19, three separate datasets of publications on these three topics were retrieved from Scopus through three separate search strategies. The decision on which general database to use (e.g. Web of Science (WoS) or Scopus) was mainly made on the basis of the number of indexed Covid-19 studies in particular, as the sector of the coronavirus literature that is currently emerging (compared to the literatures on SARS and MERS that have already stabilised). In this cluster, one can observe terms such as those associated with general public health including "wold health organisation", "public health", "public The map of keyword co-occurrences associated with the Covid-19 literature health service", "global health", as well as those associated with disease outbreaks including "emergency", "health risk" "epidemics", "pandemic", "outbreak", "viral diseases", "virus infection", "communicable disease", "transmission", "travel". doi = 10.1007/s11192-020-03706-z id = cord-300078-svu06v9c author = Haghani, Milad title = Covid-19 pandemic and the unprecedented mobilisation of scholarly efforts prompted by a health crisis: Scientometric comparisons across SARS, MERS and 2019-nCov literature date = 2020-06-01 keywords = Covid-19; MERS; SARS; study summary = To compare the scientometric aspects of the studies on SARS, MERS and Covid-19, three separate datasets of publications on these three topics were retrieved from Scopus through three separate search strategies. Figures A1 and A2 in the Appendix illustrate the map associated with the SARS literature overlaid respectively with the average year of publication and average number of citations associated with the studies where these keywords have occurred. Maps of term occurrences based on the analysis of the title and abstract of studies on SARS, MERS and Covid-19 have also been presented in Figures 7, 8 and 9 respectively. An inspection of the maps overlaid with the average year of publications for SARS and MERS in Figures A1 and A3 in the Appendix suggests that, on average, this cohort of studies are generally the last to emerge in the published domain compared to the two other major clusters, but they receive relatively high citations on average (according to Figures A2, A4 and A6). doi = 10.1101/2020.05.31.126813 id = cord-296888-z5x6zkht author = Hailay, Abrha title = The burden, admission, and outcomes of COVID-19 among asthmatic patients in Africa: protocol for a systematic review and meta-analysis date = 2020-09-04 keywords = Africa; COVID-19; study summary = title: The burden, admission, and outcomes of COVID-19 among asthmatic patients in Africa: protocol for a systematic review and meta-analysis This research protocol will, therefore, be driven to conduct systematic review and meta-analysis of the Coronavirus Disease in 2019 burden, admission and outcome among Asthmatic patients in Africa. This research protocol will, therefore, be driven to conduct systematic review and meta-analysis of the COVID-19 burden, admission and outcome among asthmatic patients in Africa. Data extraction was including information: first author, publishing month, country and/or region, signs and symptoms, complications, diagnostic criteria, comorbidity, COVID-19, study Upon introduction pick. If there will be heterogeneity between studies, we will use a meta-analysis of random-effects [24] to estimate the aggregate pooled burden, admission and outcome of COVID-19 among asthmatic patients in Africa. This systematic review and meta-analysis will be expected to quantify the burden, admission and outcome of COVID-19 among asthmatic patients in Africa. doi = 10.1186/s40733-020-00061-x id = cord-321827-e7zc44ca author = Halter, Mary title = The determinants and consequences of adult nursing staff turnover: a systematic review of systematic reviews date = 2017-12-15 keywords = intention; nurse; review; study; turnover summary = This paper reports on this overview, which aimed to identify high quality evidence of the determinants and consequences of turnover in nurses working in the field of adult health care services and bring that evidence together into one place to highlight where strong enough evidence to support managerial decisions exists and where gaps in the evidence may indicate the need for further research, particularly when considered in the context of the broader management literature regarding turnover. The empirical evidence shows that stress and issues concerning leadership consistently exert both direct and indirect effects on job satisfaction and intent to leave There are a number of published articles characterized by loosely defined terms The main reasons for reviews being in the moderate rather than strong evidence category were the lack of publication of an a priori protocol, varying levels of details about the search strategy performed, the failure to have two reviewers check the selection and data extraction, not providing a list of both included and excluded primary studies (with the exception of Toh et al. doi = 10.1186/s12913-017-2707-0 id = cord-319642-ceur0n0b author = Hamdan Alshehri, Hanan title = Factors influencing the integration of a palliative approach in intensive care units: a systematic mixed-methods review date = 2020-07-22 keywords = ICU; care; palliative; study summary = RESULTS: Four key prerequisite factors were identified: (a) organizational structure in facilitating policies, unappropriated resources, multi-disciplinary team involvement, and knowledge and skills; (b) work environment, including physical and psychosocial factors; (c) interpersonal factors/barriers, including family and patients'' involvement in communication and participation; and (d) decision-making, e.g., decision and transition, goal conflict, multidisciplinary team communication, and prognostication. In general, a palliative approach aims to relieve suffering for patients with life-limiting conditions and for those who are dying and to manage symptoms, increase the level of care comfort and provide support to family members [8, 9] . Hence, there is a need to synthesize the findings of quantitative and qualitative research studies on the factors (facilitators and barriers) influencing a palliative approach in the ICU from the perspective of allied health professionals. Four types of influencing factors were identified: (1) organizational structures, (2) working environment, (3) patient and family involvement, and (4) palliative care decision-making. doi = 10.1186/s12904-020-00616-y id = cord-330831-3b7vfv9b author = Hao, Fengyi title = A quantitative and qualitative study on the neuropsychiatric sequelae of acutely ill COVID-19 inpatients in isolation facilities date = 2020-10-19 keywords = covid-19; patient; psychiatric; psychological; study; symptom summary = COVID-19 patients reported a higher psychological impact of the outbreak than psychiatric patients and healthy controls, with half of them having clinically significant symptoms of posttraumatic stress disorder. Three themes emerged from the interviews with COVID-19 patients: (i) The emotions experienced by patients after COVID-19 infection (i.e., shock, fear, despair, hope, and boredom); (ii) the external factors that affected patients'' mood (i.e., discrimination, medical expenses, care by healthcare workers); and (iii) coping and self-help behavior (i.e., distraction, problem-solving and online support). However, there is currently limited research on the neuropsychiatric sequalae and psychological impact of COVID-19 patients, with one study so far reporting that most clinically stable patients suffered from significant posttraumatic stress disorder (PTSD) symptoms 9 . The present study performed a quantitative evaluation of the neuropsychiatric sequelae of patients with acute COVID-19 infection who received treatment in the hospital isolation wards, and compared these patients with psychiatric patients and healthy controls during the COVID-19 pandemic. doi = 10.1038/s41398-020-01039-2 id = cord-318063-bainw3d6 author = Haque, Mainul title = Health care-associated infections – an overview date = 2018-11-15 keywords = Health; Healthcare; hcai; infection; patient; study summary = Several studies suggest that simple infection-control procedures such as cleaning hands with an alcohol-based hand rub can help prevent HCAIs and save lives, reduce morbidity, and minimize health care costs. Health care-associated infections and prevention strategy About 68.6% of all bacterial isolates were resistant to cefuroxime used in the management of orthopedic SSIs. This study also found that diabetes mellitus, smoking, operations lasting more than 3 hours, the absence of antibiotic prophylaxis, and a history of previous surgery were positive risk factors associated with a significant upsurge in SSIs. 87 SSIs comprise at least 14%-22.2% of all HCAIs for abdominal surgery [88] [89] [90] and often lead to extended hospitalization and higher antimicrobial costs. Prevalence, incidence burden, and clinical impact of healthcare-associated infections and antimicrobial resistance: a national prevalent cohort study in acute care hospitals in Greece doi = 10.2147/idr.s177247 id = cord-320931-2ycf6qd8 author = Harnett, Joanna title = The effects of Sambucus nigra berry on acute respiratory viral infections: a rapid review of clinical studies date = 2020-08-22 keywords = S.nigra; study summary = The evidence included in this review is mostly derived from clinical studies involving adult participants and examining short-term use of commercial formulations of S.nigra berry for up to 16 days. Findings from included studies suggest that mono-herbal preparations of S.nigra berry (in extract or lozenge formulation) may reduce influenza-type symptoms, including fever, headache, nasal congestion and nasal mucous discharge in adults, when taken within the first 48 hours of symptom onset. Evidence regarding the effectiveness of S.nigra berry on the symptom of cough, and need for / use of medicines (including antibiotics) to treat acute respiratory infections, is currently unclear and inconsistent. Overall, the evidence obtained from the five studies included in this review involving 936 people suggests that mono-herbal preparations of S.nigra berry when taken close to the onset of symptoms and for up to two weeks, may assist in relieving the symptoms of the common cold and influenza. doi = 10.1016/j.aimed.2020.08.001 id = cord-256881-7sejcqda author = Heindel, Jerrold J. title = Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies date = 2020-07-16 keywords = BPA; Dawley; Fig; PND; Sprague; clarity; dose; effect; study summary = Additionally, we applied an integrative analysis approach by using rand Circos-plots generated with the mixOmics [21] program to identify correlations in BPA responses across organs collected from the same or comparable individual rats within this same consortium study, thus expanding our findings to a systems biology level to reveal strong organismal relationships at three different timepoints: 21 days of age (weaning), 90-120 days of age (young adult) and 6 months of age (older adult). Fenton (National Toxicology Program) (mostly using rat models); (2) DNA methylation profiles and concomitant alterations of gene expression at PND 21 are predictors of pathological outcomes that manifest during adulthood, which was done in collaboration with Dr. Shioda, Mass General Hospital); (3) perinatal exposure to BPA induces abnormal post-pubertal/adult development of the mammary gland; and (4) BPA generates non-monotonic dose-response curves. doi = 10.1016/j.reprotox.2020.05.014 id = cord-304510-sfhwaqfr author = Henssler, Jonathan title = Mental health effects of infection containment strategies: quarantine and isolation—a systematic review and meta-analysis date = 2020-10-06 keywords = health; mental; quarantine; study summary = It has been suggested that vulnerable populations at risk for negative psychological outcomes before implementation of containment strategies, e.g. persons with mental illness, low income, or lack of social network, may be at particular greater risk during and after quarantine or isolation [4] . We, therefore, conducted a systematic literature review and meta-analysis of the mental health effects of quarantine and isolation, based on controlled primary study data. For isolated/quarantined individuals, dissatisfaction with containment measures, supply, or the relationship to healthcare-personnel was associated with higher levels of anxiety and anger [13] , stress-related disorders/PTSD (2 studies [8, 14] ) and lower general mental health [8] . Large groups of the general population may be affected, but individuals who are already facing psychosocial adversities before quarantine or isolation (including persons with low income, lack of social networks, or mental health problems) appear to be among those vulnerable groups at greatest risk for negative psychological outcomes. doi = 10.1007/s00406-020-01196-x id = cord-334711-58ygbyiz author = Hernández-Sánchez, Brizeida Raquel title = Psychological Factors that Lessen the Impact of COVID-19 on the Self-Employment Intention of Business Administration and Economics’ Students from Latin America date = 2020-07-22 keywords = covid-19; entrepreneurial; intention; psychological; study summary = To meet these goals, we conducted an explorative study with a sample of college students to examine the effects of Covid-19 pandemic perception, psychological need satisfaction, proactiveness, and optimism are in entrepreneurial intentions. This research will focus on four characteristics, namely proactiveness, optimism, the Covid-19 pandemic perception, and psychological need satisfaction, to quantify the relationship between these four traits of the students and their entrepreneurial intention. First, through a representative sample of Latin American university students, this study aims to analyze the relationships between proactiveness, optimism, Covid-19 pandemic perception, psychological need satisfaction, and entrepreneurial intention in an adverse situation, as it is this current pandemic. Second, the current study focuses primarily on how the Covid-19 pandemic perception and need satisfaction mediate the predictive effects of student proactivity and optimism on entrepreneurial intention. doi = 10.3390/ijerph17155293 id = cord-265299-oovkoiyj author = Hickman, D.L. title = Commonly Used Animal Models date = 2016-11-25 keywords = Couto; Fig; Sohn; animal; model; mouse; rabbit; rat; research; study summary = The Guide for the Care and Use of Laboratory Animals, 8th edition (National Research Council, 2011) is an internationally accepted document that outlines and discusses globally accepted environmental parameters for housing different species of animals including the mouse. Rats have been used as animal models in numerous areas of research from space exploration to answering more basic scientific questions regarding nutrition, genetics, immunology, neurology, infectious disease, metabolic disease, and behavior. Being social creatures, ideally rabbits should be housed in compatible pairs or trios unless contraindicated by the research objectives or by incompatibility of the animals (Sohn and Couto, 2012) . Rabbits are very easily heat stressed and thus must be kept at significantly lower temperatures than other laboratory animals like rats and mice. Historically, chickens (Gallus domesticus) are the most common bird species studied in biomedical and agricultural research and are a classic model in areas such as immunology, virology, infectious disease, embryology, and toxicology (Scanes and McNabb, 2003; Kaiser, 2012) . doi = 10.1016/b978-0-12-802151-4.00007-4 id = cord-335141-ag3j8obh author = Higgins, G.C. title = FFP3 reusable respirators for COVID-19; adequate and suitable in the healthcare setting date = 2020-06-30 keywords = COVID-19; Hand; Health; NHS; Sir; patient; plastic; study; surgeon; surgery; time summary = The British Association of Plastic, Reconstructive and Aesthetic Surgeons, the British Society for Surgery of the Hand and the Royal College of Surgeons of England, have all issued guidance: both encouraging patients to avoid risky pursuits, which could result in accidental injuries and to members how to prioritise and optimise services for trauma and urgent cancer work. We have adapted our Hand Trauma Service to a ''One Stop Hand Trauma and Therapy'' clinic, where patients are assessed, definitive surgery performed and offered immediate post-operative hand therapy where therapists make splint and give specialist advice on wound care and rehabilitation including an illustrated hand therapy guide. Local assessment of our practice is ongoing but we have found that this model has enabled a cohort of vulnerable plastic surgery trainees to successfully continue to work whilst reducing the risk of exposure to COVID-19 and providing gold standard care for patients. doi = 10.1016/j.bjps.2020.06.002 id = cord-004314-gtwtakpr author = Holmen, Heidi title = Working with patients suffering from chronic diseases can be a balancing act for health care professionals - a meta-synthesis of qualitative studies date = 2020-02-10 keywords = CKD; COPD; care; patient; study summary = doi = 10.1186/s12913-019-4826-2 id = cord-034339-1fgbubsc author = Holz, N. E. title = Kohortenstudien in der Kinder- und Jugendpsychiatrie date = 2020-10-28 keywords = Erwachsenenalter; Kindheit; der; die; study; und summary = BACKGROUND: Longitudinal cohort studies with early start and life span perspectives are increasingly recognized as being crucial to uncover developmental trajectories as well as risk and resilience factors of psychiatric disorders. OBJECTIVE: The importance of longitudinal studies is presented and the main findings of the Mannheim study of children at risk (MARS), the adolescent brain cognitive development (ABCD), the pediatric and adolescent health survey (Kinderund Jugendgesundheitssurvey, KiGGS) and the AIMS longitudinal European autism project (LEAP) cohort studies are described. Longitudinal cohort studies with early start and life span perspectives are increasingly recognized as being crucial to uncover developmental trajectories as well as risk and resilience factors of psychiatric disorders. Die US-basierte ABCD(Adolescent Brain Cognitive Development)-Studie untersucht die Hirnentwicklung von der Kindheit bis ins Jugendalter mit dem Ziel, sowohl biologische als auch umweltbasierte Faktoren, die die Entwicklungsverläufe insbesondere im Hinblick auf Suchterkrankungen beeinflussen, aufzudecken. doi = 10.1007/s00115-020-01018-4 id = cord-307758-a4sgt66g author = Hong, Ching-Ye title = Acute respiratory symptoms in adults in general practice date = 2004-06-17 keywords = PCR; patient; study summary = Community studies have shown that ∼30% of patients with acute respiratory tract symptoms have no identifiable infective aetiology. The purpose of this study was to determine the infective aetiology in patients who presented to primary care doctors with acute respiratory symptoms. Data collection was through interview using structured questionnaire, physical examination, throat swabs for bacterial culture and nasal swabs for virus identification by immunofluorescence (IF) and polymerase chain reaction (PCR). The main objective of our study was therefore to determine the aetiological cause in patients who presented with acute respiratory symptoms in nine primary care clinics in Singapore, using bacterial culture, IF and PCR. To our knowledge, this is the first practice-based study on the aetiological diagnosis of a large group of patients presenting with URTI in primary care clinics in Asia, using IF and PCR as identification methods. doi = 10.1093/fampra/cmh319 id = cord-292209-d1ty9etr author = Horta, Bernardo L title = Prevalence of antibodies against SARS-CoV-2 according to socioeconomic and ethnic status in a nationwide Brazilian survey date = 2020-10-29 keywords = Brazil; SARS; study; test summary = Subjects answered a questionnaire on household assets, schooling and self-reported skin color/ethnicity using the standard Brazilian classification in five categories: white, black, brown, Asian or indigenous. The present analyses were aimed at assessing socioeconomic and ethnic group inequalities in prevalence of antibodies against SARS-CoV-2 in 133 sentinel cities throughout Brazil, as part of the EPICOVID-19 study (www.epicovid19brasil.org). In summary, the analyses of the three waves of national serological surveys in Brazil showed important inequalities in the prevalence of antibodies against SARS-CoV-2 according to family wealth, education and ethnic groups. Yet, even after adjustment for region, indigenous individuals were about twice as likely as whites to present antibodies against SARS-CoV-2, and in the national analyses including adjustment for region of the country and socioeconomic status, the prevalence ratio remained at around two. doi = 10.26633/rpsp.2020.135 id = cord-295575-zgta5ah8 author = Howard, Evin title = The Impact of Ambient Environmental Exposures to Microbial Products on Asthma Outcomes from Birth to Childhood date = 2019-11-28 keywords = asthma; child; study summary = The purpose of this literature review was to specifically examine asthma outcomes related to environmental exposures to microbial products, pertaining to endotoxin from bacteria-(1,3)-β-D-glucan and ergosterol from fungus, and common viruses associated with worsening asthma morbidity (rhinovirus, respiratory syncytial virus (RSV), enterovirus, and the influenza virus) during infancy, and to assess the risk of asthma development later in childhood [15] [16] [17] [18] (see Table 1 ). conducted a prospective longitudinal study examining whether early exposure to microbial products in dust was associated with allergy and asthma later in childhood for children in suburban areas using the following three birth cohort studies for children born between 1996 and 1999: [24••] , dust samples were collected from children''s mattresses, bedroom floors, and living room floors; and showed no association between endotoxin nor the fungal membrane lipid ergosterol in the development of asthma with exposure from birth to 7 years of age. doi = 10.1007/s11882-019-0890-2 id = cord-324453-gei7os7s author = Hura, Nanki title = Treatment of post‐viral olfactory dysfunction: an evidence‐based review with recommendations date = 2020-06-25 keywords = PVOD; olfactory; study summary = Studies with defined olfactory outcomes of patients treated for PVOD following medical, surgical, acupuncture, or olfactory training interventions were included. Though some pharmacological investigations offer promising preliminary results for systemic and topical medications alike, a paucity of high‐quality studies limits the ability to make meaningful evidence‐based recommendations for the use of these therapies for the treatment of PVOD. A focused literature search was performed using a combination of the following keywords: "post-viral olfactory dysfunction," "anosmia," "dysosmia," "parosmia," "olfaction disorders," "olfactory impairment," "olfactory disturbance," "olfactory loss," "smell disorder," "viral infection," "virus," "viral disease," "common cold," and "respiratory tract infection." Additional records were identified by examining the references of articles obtained for review. Studies investigating the effects of medical, surgical, or olfactory training interventions on olfaction in patients with PVOD were included. In regard to antibiotic treatment, 1 RCT of 55 patients with PVOD studying minocycline demonstrated that the medication was well tolerated, but there was no difference in overall TDI scores between the group receiving minocycline and the group receiving the placebo (p = 0.55). doi = 10.1002/alr.22624 id = cord-278246-mnj0zmkn author = Hussain, Nowair title = A Meta-Analysis on the Effects of Hydroxychloroquine on COVID-19 date = 2020-08-24 keywords = COVID-19; HCQ; study summary = HCQ treated patients had higher rates of adverse clinical outcomes and side effects compared with the control populations. The treatment of COVID-19 positive patients with HCQ has been met with controversy, as there have been no large multicenter randomized control trials to support its use. Studies 1 and 2 both do not cross the effect line at 0, indicating that they are not in agreement with the mortality rate of HCQ treated COVID-19 positive patients. All studies, except Study 6, are in agreement with the results of a disease progression rate of HCQ treatment in patients with COVID [19] . These results seem to be in line with the meta-analysis'' of a slight disease improvement in COVID-19 patients treated with HCQ as compared with the controls. Our study looks at three disease outcome measures of treatment with HCQ in patients with COVID-19: mortality rates, progression rates, and severity rates. doi = 10.7759/cureus.10005 id = cord-262127-zpt0kamn author = Hussaindeen, Jameel Rizwana title = Accommodative Insufficiency: Prevalence, Impact and Treatment Options date = 2020-09-11 keywords = accommodation; study summary = METHODS: PubMed, Google Scholar and Cochrane Collaboration search engines were used with the keywords prevalence, accommodative insufficiency, symptoms, plus lens, vision therapy and treatment. 36 Sterner et al in 2006 studied the relationship between subjective symptoms and reduced accommodative amplitude among children in the age group 6-10 years. Near addition plus lenses, vision therapy and accommodative facility training are the most commonly recommended and practiced treatment options. In a small sample of 19 children with a mean age of 10 years randomized to home-based ±1.50 DS accommodative flipper training and +1.00 DS reading addition, improvements in accommodative amplitudes and symptoms were reported in both the treatment arms, with better improvements in the facility group. A 2019 RCT by the Convergence Insufficiency Treatment Trial: Attention and Reading Trial (CITT-ART) study group showed that vision therapy for CI did not improve reading performance on standardized reading tests. doi = 10.2147/opto.s224216 id = cord-317344-wznzmssz author = Iannitti, T. title = Therapeutical use of probiotic formulations in clinical practice date = 2010-06-23 keywords = FOS; IBS; author; group; lactobacillus; patient; probiotic; study; treatment summary = Now we are going to report some of the several studies involving the use of probiotic formulations to evaluate their efficacy for the treatment of allergic diseases basing on their ability to change either the composition and/or the metabolic activities of the microbiota or modulate immune system reactivity in a way that benefits health. One hundred and sixteen patients with IBS fulfilling the Rome II criteria were randomized in a parallel group, double-blind study to receive a placebo or a probiotic combination (1  10 10 cfu) once daily for four weeks. This randomized double-blind placebo-controlled study aimed at determining the efficacy of a probiotic drink containing Lactobacillus for the prevention of any diarrhea associated with antibiotic use and caused by Clostridium difficile. doi = 10.1016/j.clnu.2010.05.004 id = cord-257400-mw38kfjo author = Iliadi, Anna title = Particulate Production and Composite Dust during Routine Dental Procedures. A Systematic Review with Meta-Analyses date = 2020-05-31 keywords = composite; dust; study summary = The aim of this systematic review was to identify, compile and evaluate existing evidence on interventions and composite material properties related to the production of aerosolized dust during routine dental procedures. Thus the broad aim of this systematic review was to collectively appraise the existing evidence on interventions and material properties related to aerosolized composite dust production in dental practice or in simulated environment, through standard dental procedures. Five of the included studies were designed to assess composite dust generated in conditions of enamel clean-up after orthodontic fixed appliances removal [22, [27] [28] [29] 32] , while the rest reported on grinding composite blocks or sticks in the lab, simulating restorative dental procedures [1, 21, [23] [24] [25] [26] 30, 31] . This is the first comprehensive report that collectively appraised the evidence from in vitro simulated or clinical reports on particulate generation and dust production after composite grinding under a range of simulated dental procedures. doi = 10.3390/ma13112513 id = cord-258781-peppszqx author = Ishola, David A. title = Could influenza transmission be reduced by restricting mass gatherings? Towards an evidence-based policy framework date = 2011-08-18 keywords = Hajj; gathering; influenza; mass; study summary = The findings of the review may be able to help inform policy statements on the effectiveness of mass gathering restriction interventions that may be deployed to help reduce influenza virus spread during a pandemic. The other five observational studies were similarly designed, involving groups of intending Hajj pilgrims who were recruited in their home regions or countries prior to the event, and then re-assessed This was a well-organized systematic prospective influenza surveillance program, described by the authors as the first of its type at a large Games event Limitations include: A number of studies [18] [19] [20] [21] [22] have consistently demonstrated, over a number of years, that respiratory virus transmission occurs amongst pilgrims attending the annual Hajj in Saudi Arabia, and it is recognized as an issue of international public health significance [43] [44] [45] [46] that could be particularly important in a pandemic situation. doi = 10.1016/j.jegh.2011.06.004 id = cord-331675-ipryt7o7 author = Itzchakov, Guy title = Can high quality listening predict lower speakers'' prejudiced attitudes?() date = 2020-08-06 keywords = Study; attitude; high; listening; quality; self summary = As compared to regular listening (in Studies 2 and 3), high quality listening will predict increased speakers'' attitude favorability (i.e., lower prejudiced attitudes) towards the outgroup by encouraging self-insight and openness to change. Specifically, the results indicated that self-insight mediated the effect of high quality listening conditions on openness to change in relation to one''s prejudiced attitudes. Specifically, we tested the effect of the listening manipulation on attitude favorability towards the prejudiced group via increasing self-insight openness to change. Thus, the mediation analysis provided support for Hypothesis 3, namely, that high quality listening will reduce speakers'' prejudiced attitudes towards the outgroup by increasing self-insight and openness to change. Study 2: Serial-mediation analysis of the effect of listening on attitude favorability towards prejudiced groups via self-insight and openness to change; standard errors in parentheses; ⁎ p < .05, ⁎⁎ p < .01. doi = 10.1016/j.jesp.2020.104022 id = cord-029423-o24dthlk author = Iwuji, Collins C. title = A phase IV randomised, open-label pilot study to evaluate switching from protease-inhibitor based regimen to Bictegravir/Emtricitabine/Tenofovir Alafenamide single tablet regimen in Integrase inhibitor-naïve, virologically suppressed HIV-1 infected adults harbouring drug resistance mutations (PIBIK study): study protocol for a randomised trial date = 2020-07-20 keywords = HIV; HIV-1; TAF; study summary = title: A phase IV randomised, open-label pilot study to evaluate switching from protease-inhibitor based regimen to Bictegravir/Emtricitabine/Tenofovir Alafenamide single tablet regimen in Integrase inhibitor-naïve, virologically suppressed HIV-1 infected adults harbouring drug resistance mutations (PIBIK study): study protocol for a randomised trial METHODS/DESIGN: A phase IV, investigator-initiated, multicentre, open label pilot, randomised two-arm study to assess the safety and efficacy of switching from bPI regimen to B/F/TAF single tablet regimen in integrase inhibitor-naïve, virologically suppressed adults with HIV-1 infection harbouring drug resistance mutations. The PIBIK trial is a phase IV, investigator-initiated, prospective, multicentre, open label pilot, randomised two arm study to assess the safety and efficacy of switching from a bPI-based regimen to B/F/TAF single tablet regimen in INSTI-naïve, virologically suppressed HIV-1 Infected adults harbouring drug resistance mutations. doi = 10.1186/s12879-020-05240-y id = cord-353787-24c98ug8 author = Jackson, J. A. title = Immunology in wild nonmodel rodents: an ecological context for studies of health and disease date = 2015-04-27 keywords = gata3; immune; infection; natural; study; system summary = Measurement of immune expression may help define individual heterogeneity in infectious disease susceptibility and transmission and facilitate our understanding of infection dynamics and risk in the natural environment; furthermore, it may provide a means of surveillance that can filter individuals carrying previously unknown acute infections of potential ecological or zoonotic importance. Potentiating much of this is the possibility of combining gene expression profiles with analytical tools derived from ecology and systems biology to reverse engineer interaction networks between immune responses, other organismal traits and the environment (including symbiont exposures), revealing regulatory architecture. Studies in wild field voles, briefly reviewed below, have aimed to identify distributional infection patterns associated with different antipathogen strategies in natural populations and to link these to expression signatures in immune-relevant genes. doi = 10.1111/pim.12180 id = cord-000955-giw4z3ei author = Jackson, Stewart title = Risk factors for severe acute lower respiratory infections in children – a systematic review and meta-analysis date = 2013-04-17 keywords = alri; study summary = doi = 10.3325/cmj.2013.54.110 id = cord-291271-movbn4dn author = Jahangiry, Leila title = Risk perception related to COVID-19 among the Iranian general population: an application of the extended parallel process model date = 2020-10-19 keywords = covid-19; efficacy; study summary = This study aimed to investigate on how people perceive the COVID-19 outbreak using the components of the Extended Parallel Process Model (EPPM) and to find out how this might contribute to possible behavioral responses to the prevention and control of the disease. To collect data an electronic self-designed questionnaire based on the EPPM was used in order to measure the risk perception (efficacy, defensive responses, perceived treat) related to the COVID-19. This study aimed to investigate on how people have perceived the COVID-19 outbreak using the components of the EPPM (efficacy, defensive responses, perceived treat) and how these might contribute to possible behavioral responses to the prevention and control of the disease. This EPPM-based study was conducted to assess the risk perceptions, overall perceived danger and fear control processes among Iranian people during the early stages of the COVID-19 pandemic. doi = 10.1186/s12889-020-09681-7 id = cord-335723-7wefotwe author = Johann, Alexandra title = The study protocol: Neuroendocrinology and (epi-) genetics of female reproductive transition phase mood disorder - an observational, longitudinal study from pregnancy to postpartum date = 2020-10-09 keywords = PPD; postpartum; study; woman summary = Therefore, the aim of the present study is to investigate numerous health-related markers to obtain greater insight into which biopsychosocial profiles render women more vulnerable to PPD or facilitate a healthy transition from pregnancy to postpartum. The present study proposes an integrative etiopathological model with distinct trajectories including (epi-) genetic vulnerability, chronic stress or adverse life events, which result in a potential dysregulation of the HPA and HPG axis and their counter-regulation and render some women more sensitive to the fluctuations of sex steroids throughout pregnancy and the postpartum period. The present study aims to provide further insight into the etiopathological mechanisms that render some women more vulnerable to mood disturbances and anxiety throughout pregnancy and the postpartum period. doi = 10.1186/s12884-020-03280-5 id = cord-345086-vq4ei1do author = Johnston, Marjorie C. title = Physical Disease and Resilient Outcomes: A Systematic Review of Resilience Definitions and Study Methods date = 2015-04-30 keywords = disease; resilience; study summary = title: Physical Disease and Resilient Outcomes: A Systematic Review of Resilience Definitions and Study Methods 10 MEDLINE, EMBASE, PsycINFO, PubMed, and the Cochrane database of systematic reviews were searched from inception to March 17, 2013 Studies in which physical disease was assessed for its association with resilient outcomes were included. The sample size restriction was applied for pragmatic reasons, as our early work demonstrated that studies of physical disease and resilient outcomes often involved complex analyses with multiple variables and that analyses with smaller populations were often underpowered. Bonanno (2004) defined adult resilience as "the ability of adults in otherwise normal circumstances who are exposed to an isolated and potentially highly disruptive event such as the death of a close relation or a violent or lifethreatening situation to maintain relatively stable, healthy levels of psychological and physical functioning …as well as the capacity for generative experiences and positive emotions. doi = 10.1016/j.psym.2014.10.005 id = cord-332559-2r2gavbq author = Kajdy, Anna title = Risk factors for anxiety and depression among pregnant women during the COVID-19 pandemic: A web-based cross-sectional survey date = 2020-07-24 keywords = GAD-7; PHQ-9; covid-19; study; woman summary = title: Risk factors for anxiety and depression among pregnant women during the COVID-19 pandemic: A web-based cross-sectional survey The secondary aim is to assess demographic, economic, and social aspects affecting maternal anxiety and depression scores among pregnant women worldwide in the time of the COVID-19 pandemic. The survey has three parts: 1) questions related to general demography, pregnancy health history, mental health history, socioeconomic factors, as well as perception of fear, burden and restrictions related to the COVID-19 pandemic and 2) General Anxiety Disorder-7 (GAD-7) questionnaire for anxiety assessment 3) Patient Health Questionnaire-9 (PHQ-9) for depression assessment. The survey consists of 60 questions, and it has the following structure: screening questions, consent form, demographic and socioeconomic questions, mental health history questions, general health history questions, pregnancy risk assessment questions, COVID-19 specific questions, and the GAD-7 and PHQ-9 scales. doi = 10.1097/md.0000000000021279 id = cord-014538-6a2pviol author = Kamilia, Chtara title = Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date = 2017-01-10 keywords = ARDS; Antoine; Ben; Care; ECMO; EEG; Fig; France; François; ICU; Intensive; January; Jean; Mohamed; NIV; Nicolas; Pierre; VAP; acute; associate; day; group; high; mortality; patient; study summary = Other parameters that were significantly different between the patients who died and those who survived were an advanced age, an elevated IGS II score at hospital admission, an elevated SOFA score at study entry, a late healthcare-associated infection and several biological variables: a high C reactive protein, low albumin and prealbumin and a poor percent of monocytes expressing HLA-DR, all measured at day 7. Parameters collected were demographic features, comorbidities, regular treatment, dyspnea assessed by the MRC scale, initial clinical severity reflected by SAPS II and APACHE II scores, modalities and ICU admission deadlines, initial arterial blood gas analysis, management of patients in the ICU (ventilation modalities, prescription of antibiotics, use of vasoactive drugs) and their outcomes (incidence of nosocomial infections and their sites, length of stay and ICU mortality). doi = 10.1186/s13613-016-0224-7 id = cord-292559-b21j9sf3 author = Karcher, Nicole R. title = The ABCD study: understanding the development of risk for mental and physical health outcomes date = 2020-06-15 keywords = ABCD; Study; development; health; risk; youth summary = The initial goal of the ABCD Study was to examine risk and resiliency factors associated with the development of substance use, but the project has expanded far beyond this initial set of questions and will also greatly inform our understanding of the contributions of biospecimens (e.g., pubertal hormones), neural alterations, and environmental factors to the development of both healthy behavior and brain function as well as risk for poor mental and physical outcomes. First, the ABCD Study utilized a school-based national recruitment strategy with limited exclusion criteria, helping to overcome challenges to previous general population studies that generally did not include neuroimaging [10] as well as attempts to understand the risk factors associated with negative outcomes that relied on convenience samples [11] . These studies provide important evidence that the ABCD Study sample can be leveraged to conduct rigorous research practices, including examining the psychometric evidence for using existing (or newly created) measures in a middle childhood sample, supporting the use of these measures to better understand the development of risk. doi = 10.1038/s41386-020-0736-6 id = cord-260112-tb087txz author = Kassardjian, Charles D. title = Practical Guidance for Managing EMG Requests and Testing during the COVID‐19 Pandemic date = 2020-04-11 keywords = EDX; study summary = The Quality and Patient Safety Committee (QPSC) of the AANEM was tasked with finding methods to help address member concerns regarding postponing EDX studies as a result of the limited availability of clinical services during the COVID-19 pandemic. Inpatient EDX studies should only be performed in urgent situations, in patients with severe deficits, and in whom EDX testing is likely to appreciably alter management by establishing a diagnosis or leading to a specific treatment. Accepted Article report of GBS in association with COVID-19 highlights the usefulness of EDX studies in differentiating causes of acute weakness in a critically ill patient, including potentially treatable conditions. In trying to limit the spread of SARS-CoV-2 infection and "flatten the curve" of the pandemic, clinicians must make difficult decisions about the urgency of EDX studies, and limit availability to patients in whom the test is absolutely essential to diagnose and appropriately treat serious neuromuscular disorders. doi = 10.1002/mus.26891 id = cord-351734-wjvhu1qg author = Kassaw, Chalachew title = The Current Mental Health Crisis of COVID-19 Pandemic Among Communities Living in Gedeo Zone Dilla, SNNP, Ethiopia, April 2020 date = 2020-08-25 keywords = COVID-19; study summary = title: The Current Mental Health Crisis of COVID-19 Pandemic Among Communities Living in Gedeo Zone Dilla, SNNP, Ethiopia, April 2020 This study aimed to assess the current mental health crisis of the COVID-19 pandemic among communities living in, Gedeo zone, Dilla, Ethiopia. The second part of the questioner was about the mental health crisis and assessed using the Depression, Anxiety and Stress Scale (DASS-21) a 21-item Likert scale and sored \ 30 (Normal), 30-43 (mild) and 43-59 (moderate) [ 60 (severe) [9] . Dependent variable-mental health crisis Independent variables-Age, sex, educational status, occupational status, family size, and monthly income, and KAP about COVID-19. Mental Health Crisis 44.4% of the respondents were reported mild to moderate psychological problem. This study found 44.4% of the respondents were reported mild to moderate psychological problems in response to COVID 19 pandemic. This study found that as there is a mental health crisis in the community living in the Gedeo zone, SNNP, Ethiopia. doi = 10.1007/s40737-020-00192-7 id = cord-352969-rpt7xja6 author = Kataria, Ashish title = COVID-19 in Kidney Transplantation: Epidemiology, Management Considerations, and the Impact on Kidney Transplant Practice date = 2020-07-15 keywords = COVID-19; SARS; patient; study; transplant summary = 1, 4 Solid organ transplant (SOT) patients including kidney transplant recipients (KTRs) are at a uniquely increased risk of serious complications from COVID-19 because of immunosuppressive (IS) medication use, elderly age (>65 y), and preexisting comorbidities like diabetes, hypertension, and cardiovascular diseases. Kidney transplant recipients may be at a uniquely increased risk of serious complications from COVID-19 as compared to the general population because of a chronically immunosuppressed state and a high prevalence of comorbidities like diabetes, heart disease, and lung disease. Kidney transplant recipients may be at a uniquely increased risk of serious complications from COVID-19 as compared to the general population because of a chronically immunosuppressed state and a high prevalence of comorbidities like diabetes, heart disease, and lung disease. 71, 72 At this time, there is no evidence to suggest that kidney transplant patients are at an increased risk of thrombotic events compared with the general population for disease of similar severity. doi = 10.1097/txd.0000000000001031 id = cord-279913-lgdmlies author = Katz, D. H. title = Proteomic Profiling in Biracial Cohorts Implicates DC-SIGN as a Mediator of Genetic Risk in COVID-19 date = 2020-06-11 keywords = ABO; COVID-19; JHS; Study summary = To understand how these loci might confer risk and whether this differs by race, we utilized proteomic profiling and genetic information from three cohorts including black and white participants to identify proteins influenced by these loci. We tested for associations between genetic variants at the ABO and 3p21.31 loci and protein levels in the three cohorts to identify possible mediators of disease. Table 1 shows the 56 proteins that associate with variants within 1MB of the transcription start site (TSS) of the ABO gene in either JHS or FHS/MDCS or both at a p-value < 5×10 -8 . . https://doi.org/10.1101/2020.06.09.20125690 doi: medRxiv preprint Proteins associated with any variant within 1MB of transcription start site of ABO gene in either Jackson Heart Study (JHS) or Framingham Heart Study (FHS)/Malmö Diet and Cancer Study (MDCS). Proteins associated with any variant within chr3:45800446-46135604 of hg38 in either Jackson Heart Study (JHS) or Framingham Heart Study (FHS)/Malmö Diet and Cancer Study (MDCS) meta-analysis. doi = 10.1101/2020.06.09.20125690 id = cord-336934-57kbz29c author = Kesteman, Thomas title = Investigating Pneumonia Etiology Among Refugees and the Lebanese population (PEARL): A study protocol date = 2019-06-13 keywords = Lebanon; answer; cap; case; lebanese; study summary = pneumoniae serotypes in nasopharyngeal and blood samples; identify the antimicrobial susceptibility profiles of the pathogenic bacteria isolated from nasopharyngeal and blood samples and compare these profiles with antibiotic prescriptions; examine the association between respiratory viral infections and invasive pneumococcal infections; identify risk factors for CAP in this population, especially those that may be modifiable (crowding, tobacco smoking, domestic sources of smoke produced by cooking or heating, etc.), and thus provide data for prevention programs; provide current data on the incidence and severity of CAP in vulnerable populations in Lebanon; provide a unique transcriptomics dataset as regards the sociodemographic profile of the patients and spectrum of diseases; compare microbiological and transcriptomic methods in estimating viral vs bacterial attributable fractions of LRTI; and assess the operational capacity of rapid, nuclear acid-based point-of-care diagnostic tests in a humanitarian crisis. doi = 10.12688/gatesopenres.12811.2 id = cord-266294-ua22udlc author = Koch, Oliver title = 29 Antiviral drugs date = 2010-12-31 keywords = CD4; HIV; drug; patient; study; therapy summary = Metabolism The hemochromatosis gene polymorphism HFE 187C> G and possibly mitochondrial haplogroup J gave relative protection against lipoatrophy during antiretroviral drug therapy in a trial in which 96 patients were randomized to didanosine þ stavudine or zidovudine þ lamivudine, combined with efavirenz and/ or nelfinavir in AIDS Clinical Trials Group (ACTG) 384 sub-study A5005s (20 C ). Gastrointestinal In a retrospective obser vational study of highly active antiretroviral therapy (HAART), 27 of 50 patients who took indinavir in combination with zidovudine and lamivudine developed nausea and were significantly more likely to stop taking the treatment than those who were taking zidovudine þ lamivudine þ tenofovir (24 c ). doi = 10.1016/s0378-6080(10)32029-0 id = cord-348841-qxkmngyk author = Kozakiewicz, Christopher P. title = Pathogens in space: Advancing understanding of pathogen dynamics and disease ecology through landscape genetics date = 2018-07-28 keywords = genetic; host; landscape; pathogen; study summary = Our review emphasizes the expanding utility of landscape genetic methods available for elucidating key pathogen dynamics (particularly transmission and spread) and also how landscape genetic studies of pathogens can provide insight into host population dynamics. We excluded reviews (n = 15), meeting abstracts (n = 1), purely methods-based papers (n = 6) and articles that identified as or mentioned landscape genetics but did not sufficiently incorporate landscape factors or genetic data into the study (n = 32), studies that referred to any of our pathogen-related search terms without it being a primary motivation for the study (n = 21), and studies that used words like "transmit" or "parasite" outside of the context of infectious agents (such as the transmission of behaviours) (n = 6). Spatial variation in pathogen prevalence or infection risk can be represented in much the same way as any landscape variable , making spatial data relating to presence of an infectious agent well-suited for incorporation into host landscape genetic models. doi = 10.1111/eva.12678 id = cord-030371-wp6xmaqe author = Kubota, Kazuo title = Basic Science of PET Imaging for Inflammatory Diseases date = 2019-12-21 keywords = CNS; FDG; F]FEDAC; TSPO; cell; macrophage; microglia; pet; study summary = Based on the critical role of neuroinflammation characterized by glial activation in neuropathogenesis, in vivo imaging with positron emission tomography (PET) is required in clinical and preclinical studies for the purposes of elucidation of pathogenesis and novel treatment development, because it is commonly available in human and experimental animal models. In a preclinical study conducted in small animal models of brain ischemia and traumatic brain injury, a second-generation TSPO tracer [ 18 F]DPA-714 PET was used for the evaluation of glial activation; the TSPO uptake was validated by comparison with the immunohistochemical findings of co-staining for TSPO and a microglial/macrophage or astrocyte maker. Although the binding affinity in humans has been shown to vary due to polymorphism, TSPO PET has been employed as an effective tool to visualize and quantify the degree of neuroinflammation associated with glial activation in preclinical studies conducted using animal models, including rodents [106] . doi = 10.1007/978-981-15-0810-3_1 id = cord-300064-t3qexner author = Kumar, Krishan title = The psychological impact of COVID-19 pandemic and lockdown on the migrant workers: A cross-sectional survey date = 2020-06-20 keywords = migrant; study summary = Accordingly, this study aims to evaluate the mental health issues among the migrant workers living in shelter houses, provided by the administration because of COVID-19 to assess the immediate and long term psychological impact of isolation. Keeping this in mind, the present study, aimed to evaluate the mental health status of the migrants who have been kept in the shelter homes, after the imposition of lockdown, due to COVID-19 pandemic. These findings suggest that the lockdown and the ongoing pandemic have a significant negative impact on the mental health of the migrant laborers. If we compare to the findings of the online survey done during the lockdown period, another important fact, which is evident from this study, is that a higher proportion of the participants screened positive for depression, rather than the anxiety. To conclude, the present study suggests that the current COVID-19 pandemic is causing severe anxiety and depressive symptoms in migrants'' workers. doi = 10.1016/j.ajp.2020.102252 id = cord-274305-mnyy41po author = Kumar, Purnima S title = Demystifying the mist: Sources of microbial bioload in dental aerosols date = 2020-07-27 keywords = aerosol; dental; oral; particle; study summary = The purpose of this review, therefore, is to examine (1) what is currently known regarding the physics of aerosol creation, (2) the types of environmental contaminants generated by dental procedures, (3) the nature, quantity, and sources of microbiota in these contaminants and (4) the risk of disease transmission from patients to dental healthcare workers. Well‐controlled, large‐scale, multi center studies using atraumatic air harvesters, open‐ended methods for microbial characterization and integrated data modeling are urgently needed to characterize the microbial constituents of aerosols created during dental procedures and to estimate time and extent of spread of these infectious agents. The purpose of this review, therefore, is to examine what is currently known regarding the physics of aerosol creation, the types of aerosols generated by dental procedures, the nature, quantity, and sources of microbiota in these aerosols and the probability of disease transmission from patients to dental healthcare workers. doi = 10.1002/jper.20-0395 id = cord-335055-gzuug3p5 author = Kwiyolecha, Elizabeth title = Patterns of viral pathogens causing upper respiratory tract infections among symptomatic children in Mwanza, Tanzania date = 2020-10-28 keywords = URTI; child; respiratory; study summary = title: Patterns of viral pathogens causing upper respiratory tract infections among symptomatic children in Mwanza, Tanzania Therefore, there is a paramount need to establish information on the common etiologies of RTIs in Tanzania, the information that can stimulate further studies and possible control interventions including introduction of cheap and reliable methods to detect these pathogens in clinical settings. In addition due to increased use of antibiotic without a support of a diagnostic test in the treatment of URTI as observed in number of previous studies [11] [12] [13] , make the availability of epidemiological data on the patterns of etiology of URTI of paramount important. A cross sectional hospital based study involving 339 children aged 1-59 months presenting with RTI symptoms was conducted from October 2017 to February 2018 in the city of Mwanza, Tanzania. A previous study 33 , documented Rhinovirus to cause up to 25-85% of the upper respiratory tract infections. doi = 10.1038/s41598-020-74555-2 id = cord-318753-ribybqfo author = Kwok, C. S. title = Influenza, influenza‐like symptoms and their association with cardiovascular risks: a systematic review and meta‐analysis of observational studies date = 2015-05-04 keywords = influenza; study summary = The quality of included studies was evaluated using a risk of bias assessment including: ascertainment of exposure to influenza, ascertainment of selected cardiovascular outcomes and adjustments for potential confounders. We stratified the main analysis based on the measures of ascertaining influenza (e.g. laboratory serology tests or based on clinical presentation suggesting influenza-like illness) and use of adjustments to account for potential confounders. Our findings suggest that exposure to influenzalike illnesses may be associated with increased risk of cardiovascular events, hence measures such as influenza vaccination should be supported in line with current recommendations, particularly among patients who are at risk of CVDs. The definition of influenza varied among studies in the current analysis since both serological tests and clinical assessments were used. We have observed that influenza-like illness defined by clinical features, which may be caused by both influenza and other viral infections such as those highlighted above are associated with an increased risk of MI. doi = 10.1111/ijcp.12646 id = cord-262637-crqw59k1 author = Kwon, Sophia title = Food Intake REstriction for Health OUtcome Support and Education (FIREHOUSE) Protocol: A Randomized Clinical Trial date = 2020-09-09 keywords = BMI; FIREHOUSE; WTC; study summary = We will randomize subjects (1:1) to either: (1) Low Calorie Mediterranean (LoCalMed)—an integrative multifactorial, technology-supported approach focused on behavioral modification, nutritional education that will include a self-monitored diet with feedback, physical activity recommendations, and social cognitive theory-based group counseling sessions; or (2) Usual Care. In light of these findings, we focused our work on the inflammatory effects of lipids in the development of particulate matter (PM)-induced lung injury [22] To investigate the potential reversibility of WTC-LI by direct impact on MetSyn risk factors, we focus on calorie-restricted (CR) Mediterranean diets based on recent studies showing their ability to attenuate lipid levels [20, 23, 24] . At baseline, participants will be provided in-person, group-based technology training, and will receive handouts with the following study goals: (1) weight loss of ≥seven percent at 6-months; (2) saturated fat intake ≤seven percent of kcal; (3) ≥150-min per week of moderate-intensity physical activity. doi = 10.3390/ijerph17186569 id = cord-288487-hs3wfffs author = Lambert, Stephen B title = The cost of community-managed viral respiratory illnesses in a cohort of healthy preschool-aged children date = 2008-01-24 keywords = ARI; cost; influenza; study summary = The point estimate of the mean cost of community-managed influenza illnesses in healthy preschool aged children is three times greater than those illnesses caused by RSV and other respiratory viruses. Even for influenza, the most studied of all respiratory viruses, cost-of-illness and vaccine cost-effectiveness evaluations in children have tended to rely on assumptions or use retrospectively collected estimates, often from surveys, for resource utilisation, such as carer time away from work in seeking healthcare or caring for an ill child [6] [7] [8] [9] . Despite overlapping confidence intervals, the finding of most note in this study was the dramatically higher point estimate of the mean cost of influenza A ARIs, being three times higher than illnesses caused by RSV and the other common respiratory viral infections of childhood. Further studies that collect primary, integrated epidemiologic and economic data, particularly indirect costs, directly from families about community-managed ARIs in children, are required. doi = 10.1186/1465-9921-9-11 id = cord-255351-vp19ydce author = Lanata, Claudio F. title = Global Causes of Diarrheal Disease Mortality in Children <5 Years of Age: A Systematic Review date = 2013-09-04 keywords = child; pathogen; study summary = We present the results of a systematic literature review of studies of diarrhea etiology in hospitalized children and use these results to estimate the global burden of diarrhea mortality by pathogen for children under 5 years of age for 2011. From 22 643 citations identified in the electronic search, 1 003 articles were selected for further evaluation (Fig. 1) ; 840 articles were excluded because they had one or more of the exclusion criteria (About 35% because they were not longitudinal studies or inappropriate laboratory methods were used, 31% because no data was given for children ,5 years of age, 23% for studies that lasted less than 12 months of duration, and the rest because data were reported after rotavirus vaccine introduction, duplicate publications or reporting results on a pathogen not included in our list). doi = 10.1371/journal.pone.0072788 id = cord-028963-u4iupl1s author = Lane, Michael title = Multiple Sclerosis date = 2020-07-10 keywords = CNS; diet; multiple; sclerosis; study summary = Natalizumab is a monoclonal antibody against α-4 integrin that prevents inflammatory cells from entering the CNS and has been shown to decrease the annualized relapse rate by 68% and reduce disease activity (new or enlarging MRI lesions) by 83% over 2 years compared with placebo. Based on current knowledge of the pathogenesis of MS, the rationale of using the Swank diet or other diets low in saturated fats in patients with MS relates to the general health benefits of such a diet and the anti-inflammatory and perhaps neuron membrane-stabilizing effects of a diet enriched with O3FAs. Although the consumption of red meat is significantly restricted on the Swank diet, fish appears to be particularly indicated because of its excellent protein content and, perhaps more importantly, its high content of O3FAs. Cold-water fish such as mackerel, salmon, and herring are rich in O3FAs, which include eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). One open-label study in RRMS patients (n = 10) showed a significant decrease in MMP-9 levels secreted from unstimulated immune cells after supplementing with fish-oil concentrate at 8 g/day (containing 2.9 g EPA and 1.9 g DHA) for 3 months. doi = 10.1016/b978-0-323-43044-9.00199-0 id = cord-013138-4e9vo0xr author = Lang-Illievich, Kordula title = The Effect of Low-Level Light Therapy on Capsaicin-Induced Peripheral and Central Sensitization in Healthy Volunteers: A Double-Blinded, Randomized, Sham-Controlled Trial date = 2020-10-10 keywords = LLLT; effect; pain; study summary = title: The Effect of Low-Level Light Therapy on Capsaicin-Induced Peripheral and Central Sensitization in Healthy Volunteers: A Double-Blinded, Randomized, Sham-Controlled Trial INTRODUCTION: Several clinical trials have demonstrated that low-level light therapy (LLLT), a method of photobiomodulation, is an effective analgetic treatment. This study aimed to evaluate the effect of low-level light therapy on primary and secondary hyperalgesia in a human pain model. CONCLUSIONS: Our data indicate that low-level light therapy is effective at reducing the heat and mechanical pain threshold in a human pain model, pointing to a significant modulating effect on peripheral and central sensitization. To provide an answer to these questions, we use a human pain model developed to mimic different aspects of clinical pain and to study pain mechanisms in order to examine whether peripheral or central mechanisms contribute to the analgetic effect of LLLT. doi = 10.1007/s40122-020-00205-0 id = cord-281877-r1y1hz4q author = Lavretsky, Helen title = Scientific Autobiography of a Spiritual Seeker in the Year of Hindsight''s 20/20.: “Was I deceived, or did a sable cloud Turn forth her silver lining on the night?” John Milton “Comus” (1634) date = 2020-08-11 keywords = old; research; study summary = have been a big part of my spiritual journey focused on seeking to understand the true nature of human mental and emotional suffering and resilience, where all life events are assumed to provide valuable lessons and "silver linings" that ensure individual and collective evolution of consciousness. I also learned to use the intervention studies to understand brain mechanisms of treatment response, while developing novel pharmacological and behavioral interventions and mastering advanced research tools like neuroimaging, genetics, inflammatory markers (9) (10) (11) (12) . We hope to empower our patients to take control of their own health and learn resilience-building tools to allow for self-regulation during these difficult times and for stress-related psychiatric disorders. However, providing patients with the ability to learn about their own strengths and utilize their lifestyle choices and spirituality to improve treatment outcomes is another powerful therapeutic and preventive approach to neuropsychiatric diseases of late life, such as depression, caregiver stress and dementia. doi = 10.1016/j.jagp.2020.08.002 id = cord-287742-y1j9x5ne author = Lee, Kai Wei title = Stroke and Novel Coronavirus Infection in Humans: A Systematic Review and Meta-Analysis date = 2020-10-06 keywords = COVID-19; SARS; patient; stroke; study summary = Therefore, we performed a systematic review and meta-analysis of currently available epidemiological, clinical, and laboratory data related to both stroke and COVID-19 infection. We, therefore, performed a systematic review and metaanalysis involving the epidemiological, clinical presentation, imaging characteristics, and laboratory finding related to both stroke and COVID-19 infection. The following data were extracted from every study: the last name of the first author, year of publication, country, severity status, study design, patient characteristics (ethnicity composition, gender, and mean age), comorbidities (diabetes, hyperlipidemia, hypertension, ischemic heart disease, heart failure, previous stroke, chronic kidney disease/end-stage renal disease, number of stroke patients per overall participants, any information relevant to strokes such as the location of stroke [arterial or venous]), types of stroke (ischemic or haemorrhagic), classification of stroke, mortality rate, and blood parameters. The aim of this current study is to perform a systematic review and meta-analysis concerning the epidemiological, clinical presentation, imaging characteristics, and laboratory findings related to both stroke and COVID-19 infection. doi = 10.3389/fneur.2020.579070 id = cord-289305-mfjyjjer author = Lee, Min Hye title = A systematic review on the causes of the transmission and control measures of outbreaks in long-term care facilities: Back to basics of infection control date = 2020-03-10 keywords = gas; outbreak; study summary = title: A systematic review on the causes of the transmission and control measures of outbreaks in long-term care facilities: Back to basics of infection control Three studies on gastrointestinal infection, in which adherence to hand hygiene among HCWs was crucial to prevent its spread, reported control measures including stringent hand hygiene practice and reinforcement of standard precautions [23, 27, 31] . The study on the RSV and HMPV outbreak reported various measures including active surveillance, isolation, contact precaution, antiviral prophylaxis for residents and work restriction for ill staff to control respiratory pathogen transmission [50] . This update for understanding outbreaks in LTCFs by reviewing recent studies indicates that staff members and residents are still at risk for contagious disease outbreaks including influenza, gastroenteritis, and GAS infection. Influenza outbreak control practices and the effectiveness of interventions in long-term care facilities: a systematic review doi = 10.1371/journal.pone.0229911 id = cord-286932-2gjnpqqa author = Lee, Yung title = Impact of hospital lockdown secondary to COVID-19 and past pandemics on surgical practice: A living rapid systematic review date = 2020-11-12 keywords = COVID-19; HCW; study summary = title: Impact of hospital lockdown secondary to COVID-19 and past pandemics on surgical practice: A living rapid systematic review We included studies that assessed postoperative patient outcomes or protection measures for surgical personnel during epidemics. CONCLUSIONS: This review highlights postoperative patient outcomes during worldwide epidemics including the COVID-19 pandemic and identifies specific safety measures to minimize infection of healthcare workers. Studies reporting outcomes of patients undergoing surgery during an epidemic-caused hospital lockdown and studies investigating the impact of lockdown on surgical HCW and surgical practice were included. 23,29,35 Fourteen studies described modifying the roles of HCW during epidemics, including formation of an "Emergency Incident Command Team" to identify and separate infected patients from other patients, allowing only essential personnel to be present during procedures, and assigning staff to conduct patient screening full-time. 21 No infections or adverse outcomes were reported for HCW during the SARS epidemics (0/128) from the included studies. doi = 10.1016/j.amjsurg.2020.11.019 id = cord-314288-6vh7dvad author = Leibovici, L. title = Submissions and publications in Corona times date = 2020-05-15 keywords = study summary = In times of the COVID-19 pandemic we struggle at CMI between the urge to bring data to the readers as soon as possible and the necessity to publish trustworthy, robust material. Letters to the Editor: Under this format we publish interesting case reports and case series; and as expected we received many letters describing one (or a few) patients with presentations of COVID-19 that had not been described before. Systematic reviews and meta-analyses of small observational studies, with ingrained biases, are not helpful. Observational studies: Now we have a good idea from published studies on the clinical course of COVID-19, and further descriptions of small groups of patients have little to add. Several studies have already been published on risk factors for symptomatic disease, severe disease and death in patients affected by the virus. Considering our readers, we publish studies on diagnostics only if tested on clinical samples, and preferably in clinical situations [6] . doi = 10.1016/j.cmi.2020.05.008 id = cord-345454-r1ymzk6n author = Levesque, J. title = A note on COVID-19 seroprevalence studies: a meta-analysis using hierarchical modelling date = 2020-05-06 keywords = GLMM; study; test summary = Many of these studies find an antibody prevalence comparable to the false positive rate of their respective serology tests and the relatively low statistical power associated with each study has invited criticism. To determine the strength of the signal, we perform a meta-analysis on the publicly available seroprevalence data based on Bayesian hierarchical modelling with Markov Chain Monte Carlo and Generalized Linear Mixed Modelling with prediction sampling. The Santa Clara study shows a density function consistent with a high probability of a non-zero antibody prevalence, with a mean and a mode slightly greater than 1%, although we note that the posterior distribution does include zero. Figure 2 : The two dimensional marginal posterior distribution functions for antibody prevalence with the false positive rate at each study location from Bayesian hierarchical model. Figure 7 shows the resulting density functions for the antibody prevalence in each location from the GLMM prediction sampling. doi = 10.1101/2020.05.03.20089201 id = cord-353528-8a3f5hxu author = Levy, Oren title = Shattering barriers toward clinically meaningful MSC therapies date = 2020-07-22 keywords = IBMIR; MSC; cell; clinical; mesenchymal; stem; study; therapeutic summary = Although the mechanism of action in human patients is not well elucidated, results from pre-clinical studies of Alofisel indicate that induction of indoleamine 2,3-dioxygenase (IDO) in the presence of inflammatory factors such as interferon- (IFN-) is critical for the therapeutic effect of MSCs. This is because the enzymatic activity of IDO can inhibit T cell function and proliferation and increase the number of regulatory T cells, leading to an increase in anti-inflammatory cytokines [e.g., interleukin-10 (IL-10)] and decrease in pro-inflammatory cytokines [e.g., IFN- and tumor necrosis factor- (TNF-)] (14) . (64) reported that MSCs genetically engineered to express thioredoxin-1 (Trx1)-a powerful antioxidant, transcription factor, and growth factor regulator-improved cardiac function following MI in a rat model compared to unmodified MSCs. Although preclinical Priming MSCs with small molecules is a simple and promising approach to induce the secretion of immunomodulatory and regenerative molecules, but the effect of small molecules only lasts a few hours to a few days. doi = 10.1126/sciadv.aba6884 id = cord-031243-p6142nt1 author = Lewis, Mae M. title = From Study-Abroad to Study-at-Home: Teaching Cross-Cultural Design Thinking During COVID-19 date = 2020-09-01 keywords = portuguese; student; study summary = The online format replaced these site visits with ''''virtual field trips'''' featuring YouTube videos and readings and were assessed by discussion board posts relating them to other course activities. Students individually perform start-of-course and end-of-course self-assessments of their Global Learning and their Intercultural Knowledge and Competence 5,6 and respond to free-response reflection prompts inspired by the set proposed by the University of Michigan for international programs in engineering, 10 though substantial modifications were made for the transition to online learning. Some key ideas typically noted from interviews conducted by study-abroad students were observed in the online format as demonstrated by the students'' written reflections and actionable problem statements, e.g., differences between the US and Portuguese governments'' roles in healthcare. The online version of the class retained some of the major learning objectives in AI, breast cancer, and the role of culture in healthcare delivery and design of healthcare technologies through interviews, discussion board posts, concept maps, and tweetable actionable problem statements. doi = 10.1007/s43683-020-00018-9 id = cord-350565-mejd7blb author = Lewnard, Joseph A title = Emerging Challenges and Opportunities in Infectious Disease Epidemiology date = 2019-03-16 keywords = EBOV; Ebola; United; disease; study; vaccine summary = We next consider emerging paradigms in causal inference for infectious diseases, ranging from approaches to evaluating vaccines and antimicrobial therapies to the task of ascribing clinical syndromes to etiologic microorganisms, an age-old problem transformed by our increasing ability to characterize human-associated microbiota. We next consider emerging paradigms in causal inference for infectious diseases, ranging from approaches to evaluating vaccines and antimicrobial therapies to the task of ascribing clinical syndromes to etiologic microorganisms, an age-old problem transformed by our increasing ability to characterize human-associated microbiota. Although serosurveys have bolstered recent efforts to understand the geographic range and clinical spectrum of EBOV and Zika virus infections (47, 48) , the enhancement of dengue hemorrhagic fever risk by prior exposure (49) , and the role of immunologic history in influenza susceptibility and vaccine response (50) , there remain few examples of public health programs undertaking serological studies for routine surveillance, at least in civilian populations (51) . doi = 10.1093/aje/kwy264 id = cord-325512-eehp4uh9 author = Li, Yiwei title = Coronavirus disease 2019 (COVID-19) related cytopenia: A protocol for systematic review and meta-analysis date = 2020-09-04 keywords = COVID-19; study summary = title: Coronavirus disease 2019 (COVID-19) related cytopenia: A protocol for systematic review and meta-analysis This systemic review and meta-analysis summaries the latest evidence from available data and determine the hematological abnormality caused by severe acute respiratory syndrome coronavirus 2 and potential efficacy on the outcomes in patients with COVID-19. The meta-analysis was performed by RevMan V.5.3 program and Stata V.12.0 software after 2 reviewers independently selected literature, data extraction, bias risk evaluation and study quality assessment. RESULTS: This systematic review and meta-analysis may help provide clarify on the effect of cytopenia in patients with COVID-19. This study will be conducted in accordance with the preferred reporting items for systematic reviews and meta-analysis protocols 2015 guidelines and the protocol has been registering in the PROSPERO database (Registration number: CRD42020187524) on 22 May 2020. The process of study selection is illustrated following a preferred reporting items for systematic reviews and meta-analysis guidelines (Fig. 1 ). doi = 10.1097/md.0000000000022033 id = cord-016130-5q9ufu28 author = Linday, Linda A. title = Nutritional Supplements and Upper Respiratory Tract Illnesses in Young Children in the United States date = 2010-12-17 keywords = States; United; child; cod; liver; oil; study; vitamin summary = Our clinical research demonstrates that daily supplementation with a flavored cod liver oil (which meets European purity standards) and a children''s multivitamin-mineral with trace metals, including Se, can decrease morbidity from upper respiratory tract illnesses, otitis media, and sinusitis in young children living in the United States. This chapter discusses the role of essential fatty acids, vitamins, and trace metals in the pathophysiology of inflammation; reviews our clinical research on the use of a lemon-flavored cod liver oil (which meets European purity standards) and a children''s chewable multivitamin-mineral with Se for the prevention and adjunctive treatment of these disorders; reviews the history of cod liver oil, including its importance in the discovery of vitamin D and the anti-infective properties of vitamin A; and discusses the current clinical use of these supplements. doi = 10.1007/978-1-59259-880-9_21 id = cord-269343-qwgmn06t author = Livingston, Gill title = Dementia prevention, intervention, and care: 2020 report of the Lancet Commission date = 2020-07-30 keywords = Alzheimer; Association; TBI; cognitive; dementia; people; risk; study; year summary = Overall, a growing body of evidence supports the nine potentially modifiable risk factors for dementia modelled by the 2017 Lancet Commission on dementia prevention, intervention, and care: less education, hypertension, hearing impairment, smoking, obesity, depression, physical inactivity, diabetes, and low social contact. 90 An individual-level meta-analysis of 19 observational studies of relatively younger adults included 404 840 participants'' data (mean baseline age 45·5 years; mean follow-up duration 14·9 years), reporting an increased incidence of all-cause dementia (HR 1·4, 95% CI 1·2-1·7) and clinically diagnosed Alzheimer''s disease (1·4, 1·1-1·7) in those who were physically inactive in the 10-year period before diagnosis. Little evidence of the effects of social interventions on dementia exists but a systematic review of low quality RCTs of 576 adults aged 60 or more years with normal cognition found facilitated meeting and discussion groups were associated with improved global cognition and increased brain volume at follow-up. doi = 10.1016/s0140-6736(20)30367-6 id = cord-334849-8rblgq9b author = LoPresti, Marissa title = The Role of Host Genetic Factors in Coronavirus Susceptibility: Review of Animal and Systematic Review of Human Literature date = 2020-08-12 keywords = ACE2; COVID-19; SARS; genetic; study summary = 1 As with many complex diseases, the reality for most individuals likely involves a combination of genetic -including viral and host genetics -and non-genetic Relative to other coronaviruses, SARS-CoV-2 has unique biological properties and related clinical impact, but data regarding other coronaviruses may be relevant. This can help populate lists of genes that -along with data from related biological studies -may bear scrutiny in the developing and important large-scale host genetic 6 and porcine epidemic diarrhea virus (PEDV)in pigs. In various species, efforts have focused on genes encoding the relevant coronavirus receptor, including effects of viral and host genetic changes and how these may impact the disease process. 30 In humans (see Tables 1 and S2 and Figures 3 and 4 for details on human studies of these genes, including specific references), studies of specific ACE2 polymorphisms have not shown significant associations with SARS-CoV-1 susceptibility or outcome. doi = 10.1016/j.ajhg.2020.08.007 id = cord-022467-j2trahab author = Loo, May title = Select Populations: Children date = 2009-05-15 keywords = ADHD; United; acupuncture; asthma; cam; child; chinese; clinical; study; therapy; treatment summary = A recent clinical trial that included children over age 12 years and used a fixedcombination homeopathic remedy for a mean 4.1 days of treatment reported that 81.5% reported subjective feelings of being symptom free or significantly improved without complaint of any adverse side effects. 4 A randomized, double-blind, placebocontrolled study from Great Britain of 170 children with a starting median age of 4.2 years in the experimental group and 3.6 years in the placebo group concluded that individually prescribed homeopathic remedies seem to be ineffective in reducing symptoms or decreasing the use of antibiotics in pediatric patients with URI. 414 In a nonrandomized clinical trial involving 30 children ages 3 months to 8 years with chronic diarrhea of 2 to 4 months'' duration that was unresponsive to Western medicine and TCM, individualized acupuncture treatment eliminated symptoms and normalized stools. doi = 10.1016/b978-0-323-02028-2.50015-2 id = cord-278297-twiye6jv author = Lourenco, Stella F. title = No Participant Left Behind: Conducting Science During COVID-19 date = 2020-05-11 keywords = online; study summary = Although research conducted online solves the problem of data collection, a lack of internet access among low-income and minority communities may reduce the diversity of study samples and, thus, impact the generalizability of scientific findings. Indeed, many child development laboratories are going online for the first time, a shift that is being facilitated by resources such as the Parent and Researcher Collaborative (https://childrenhelpingscience.com), a single, crowd-sourced platform where researchers from different labs can post their studies for families to participate in. As excited as we are about the promises of online testing (e.g., in fields like developmental psychology where data collection is typically slow and expensive), we are also concerned about how the demographics of online participants may shift during COVID-19. In particular, we worry that online testing may reduce the diversity of participants--especially those from low-income and minority households-whose participation in scientific research has been essential in understanding all sorts of phenomena, from language proficiency [4] and spatial reasoning [5] to academic achievement [6] and brain development [7] . doi = 10.1016/j.tics.2020.05.003 id = cord-267132-nb0j6k3h author = Loveday, H.P. title = epic3: National Evidence-Based Guidelines for Preventing Healthcare-Associated Infections in NHS Hospitals in England date = 2013-12-10 keywords = ABHR; BSI; CAUTI; HCAI; Health; catheter; hand; infection; patient; study summary = Clinical effectiveness (i.e. using prevention measures that are based on reliable evidence of efÀ cacy) is a core component of an effective strategy designed to protect patients from the risk of infection, and when combined with quality improvement methods can account for signiÀ cant reductions in HCAI such as meticillin-resistant Staphylococcus aureus (MRSA) and Clostridium difÀ cile. Full text conÀ rms that the article: relates to infections associated with hospital hygiene; is written in English; is primary research (randomised controlled trials, prospective cohort, interrupted time series, controlled before-after, quasi-experimental, experimental studies answering speciÀ c questions), a systematic review or a meta-analysis including the above designs; and informs one or more of the review questions. 334 In a prospective cohort study using data from two randomised trials and a systematic review to estimate rates of PICC-related bloodstream infection in hospitalised patients, the author concluded that PICCs used in high-risk hospitalised patients are associated with a rate of CR-BSI similar to conventional CVCs placed in the internal jugular or subclavian veins (two to À ve per 1000 catheter-days). doi = 10.1016/s0195-6701(13)60012-2 id = cord-310027-846vp7ii author = Ma, Lin-Lu title = Coronavirus Disease 2019 Related Clinical Studies: A Cross-Sectional Analysis date = 2020-09-02 keywords = COVID-19; SARS; clinical; study summary = METHODS: We did an electronic search of COVID-19 related clinical studies registered between December 1, 2019 and February 21, 2020 (updated to May 28, 2020) from the ClinicalTrials.gov, and collected registration information, study details, recruitment status, characteristics of the subjects, and relevant information about the trial implementation process. We extracted the following information from registered studies: registration number, registration date, registration title, primary sponsor, funding source, study type, study phase, study objectives, study design, length of the study, intervention, countries of recruitment and research settings, recruiting status, allocation, sample size, participant age, gender, masking, the time and method of sharing individual participant data (IPD), data management committee. Among the 943 interventional studies, 416 studies (44.1%) explored the effectiveness and/or safety of drugs commonly used in preventing and treating COVID-19, such as hydroxychloroquine (HCQ), chloroquine (CQ), immunotherapy (including stem cell therapy, monoclonal antibody, immunoregulation), lopinavir/ritonavir, glucocorticoids, interferon, targeted therapy (Baricitinib, Ruxolitinib, Imatinib), favipiravir, and Remdesivir. doi = 10.3389/fphar.2020.540187 id = cord-320976-y47p1c15 author = Madhwal, Sandeep title = Ambient bioaerosol distribution and associated health risks at a high traffic density junction at Dehradun city, India date = 2020-02-22 keywords = bioaerosol; concentration; study summary = An airborne bioaerosol assessment study was carried out at a high traffic density junction focusing on their concentration, contribution in respirable particulate matter (PM), and factors influencing the distribution and microbial diversity. The objectives of the study were to (i) investigate the temporal variation of cultivable airborne fungal and bacterial aerosols, (ii) understand the bioaerosol size distribution and their percentage contribution to PM, and (iii) characterize the microbial diversity at the study site. Again, this explanation is supported by the statistically significant correlation observed between bioaerosol concentrations and vehicle count during the study period (r = 0.81 and 0.73 for bacteria and fungi, respectively) (p < 0.05). Further, both bacterial and fungal bioaerosols showed no significant relationship (p > 0.05) with the rest of the meteorological variables (i.e., wind speed, solar radiation, and PBLH) suggesting that their distribution at the study site is chiefly affected by nonmeteorological factors. doi = 10.1007/s10661-020-8158-9 id = cord-348490-dqabq6d8 author = Maeder, Muriel N. title = Sickle-cell disease in febrile children living in a rural village of Madagascar and association with malaria and respiratory infections date = 2016-12-01 keywords = Madagascar; SCD; respiratory; study summary = title: Sickle-cell disease in febrile children living in a rural village of Madagascar and association with malaria and respiratory infections From May 2011 to November 2013, a cross-sectional study was conducted in the rural village of Ampasimanjeva in the south east cost of Madagascar aiming to identify blood-borne protein biomarkers that can differentiate the causes of unexplained acute febrile illness in children. Our study shows that prevalence of SCD was 2.4% and that of SCT 23.8% among children aged 2-59 months presenting with fever and living in high endemic area for malaria. However, among the 23 viral and atypical bacteria pathogens studied, there was no statistical difference in prevalence between the three groups for 20 of them and include HRV the most common respiratory virus detected or influenza virus A (H1N1)/ pdm09 known to increase disease severity in children with SCD [29] . doi = 10.1186/s12878-016-0069-1 id = cord-286237-x6dr6rsh author = Maes, Bastiaan title = Treatment of severely ill COVID-19 patients with anti-interleukin drugs (COV-AID): A structured summary of a study protocol for a randomised controlled trial date = 2020-06-03 keywords = Anakinra; COVID-19; IL-1; IL-6; patient; study; subject summary = -mechanical ventilation > 24 h at randomization -clinical frailty scale above 3 -active bacterial or fungal infection -unlikely to survive beyond 48h -neutrophil count below 1500 cells/microliter -platelets below 50.000/microliter -Patients enrolled in another investigational drug study -patients on high dose systemic steroids (> 8 mg methylprednisolone or equivalent for more than 1 month) for COVID-19 unrelated disorder -patients on immunosuppressant or immunomodulatory drugs -patients on current anti-IL1 or anti-IL6 treatment -signs of active tuberculosis -serum transaminase levels >5 times upper limit of normal, unless there are clear signs of cytokine release syndrome defined by LDH >300 IU/L and ferritin >700 ng/ml -history of (non-iatrogenic) bowel perforation or diverticulitis -Pregnant or breastfeeding females (all female subjects deemed of childbearing potential by the investigator must have negative pregnancy test at screening) 5.2.1. doi = 10.1186/s13063-020-04453-5 id = cord-255230-i6q73bhs author = Makhanova, Anastasia title = Capturing Fluctuations in Pathogen Avoidance: the Situational Pathogen Avoidance Scale date = 2020-08-13 keywords = Study; avoidance; pathogen; spa summary = Across six studies, we demonstrate the reliability and validity of the SPA scale, show that the scale is influenced by situational activation of pathogen avoidance motives, and demonstrate that it mediates the association between pathogen avoidance motives (both chronic and situational) and social biases against obese and foreign targets. Study 1 is a preliminary study intended to establish the reliability and factor structure of the scale and examine predictive validity by assessing the association between the SPA scale and aversive reactions toward an obese target (a heuristic cue associated with pathogen avoidance). Study 1 provides initial evidence for the reliability and the one-factor structure of the SPA scale and examined whether SPA scores were associated with bias against a target linked to heuristic pathogen threat (an obese target). Additionally, individuals who reported higher (relative to lower) SPA scores also reported more aversive reactions toward an obese target, consistent with prior research linking pathogen avoidance to prejudice against targets heuristically associated with illness. doi = 10.1007/s40806-020-00256-8 id = cord-293186-yxpkqbey author = Mamo, Yitagesu title = Perception Toward Quarantine for COVID-19 Among Adult Residents of Selected Towns in Southwest Ethiopia date = 2020-10-30 keywords = COVID-19; perception; quarantine; study summary = The aim of this study was to assess public perceptions toward quarantine for COVID-19 and associated factors among adult residents of selected towns in Southwest Ethiopia, 2020. 3 A broad range of public health strategy would be employed against a pandemic disease like COVID-19, from relatively innocuous techniques, such as disease surveillance and hygienic measures, to considerably more restrictive interventions, such as social distancing, travel restrictions, quarantine, and case isolation. Therefore, the aim of this study was to assess community perception toward quarantine for COVID-19 and associated factors among adult residents of selected towns in Southwest Ethiopia, 2020. After controlling possible confounding variables in multiple linear regression, having training on COVID-19, educational status, occupation, knowledge of COVID-19, and knowledge of quarantine were significantly associated with perception toward quarantine. According to this study, having training on COVID-19 was positively associated with perception toward quarantine. The finding from this study also revealed that knowledge of COVID-19 was associated with more positive perception of quarantine. doi = 10.2147/ijgm.s277273 id = cord-268417-6eyetb5i author = Mandel, Benjamin title = Neutralization of Animal Viruses date = 1978-12-31 keywords = Fab; Mandel; Yoshino; antibody; complement; neutralization; study; virus summary = Somewhat earlier, Morgan (1945''1 had reported that discrepancies in the quantitative aspects of the neutralization of WEE virus by immune rabbit sera were related to the use of fresh or heated serum, and that the addition of complement to the latter tended to eliminate the discrepancies. Further studies (Radwan et al., 1973) showed that the addition of complement to virus complexed with dependent antibody eventually resulted in lysis of the viral membrane. It was also shown (Yoshino and Taniguchi, 1966 ) that antibodies induced in guinea pigs by immunization, and in humans following herpes infection, were initially dependent and later independent of complement for neutralizing activity. A relevant observation has been made in several studies; neutralization of infectious virus-antibody complexes by antiglobulin also shows a single-hit mechanism, and at a rate that exceeds the rate of the homotypic reaction. doi = 10.1016/s0065-3527(08)60101-3 id = cord-253000-nwbmxepi author = Margină, Denisa title = Chronic Inflammation in the Context of Everyday Life: Dietary Changes as Mitigating Factors date = 2020-06-10 keywords = diet; dietary; disease; effect; inflammation; metabolic; study summary = Fasting in combination with calorie restriction modulates molecular mechanisms such as m-TOR, FOXO, NRF2, AMPK, and sirtuins, ultimately leads to significantly reduced inflammatory marker levels, as well as improved metabolic markers. It has been found that intermittent fasting can prevent and reverse all aspects of metabolic syndrome in rodents: body fat, inflammation, and blood pressure are reduced; insulin sensitivity is increased; and the functional capacity of the neuromuscular and cardiovascular systems are improved [151] [152] [153] . In another study, which used the same fasting guidelines, improved metabolic markers were observed after periodic fasting, including a decrease in blood glucose levels associated with changes in gut microbiome composition [73] . These changes include increased fiber and polyphenol intake compared to the current western diets, but also well-structured, personalized fasting protocols, which can reduce the risk of metabolic disorders (Figure 3) . doi = 10.3390/ijerph17114135 id = cord-280111-6hiuzkvz author = Maspero, Cinzia title = Available Technologies, Applications and Benefits of Teleorthodontics. A Literature Review and Possible Applications during the COVID-19 Pandemic date = 2020-06-17 keywords = orthodontic; patient; study; treatment summary = This literature review aims at reducing in-office appointments by providing an overview of the technologies available and their reliability in the long-distance monitoring of patients, i.e., teledentistry. As no reviews have yet been carried out on the efficacy of teleassistance in orthodontics as a way to manage patients at a distance, we would like to report on the evidence available as to the possibility of implementing new technologies in teleassistance, generally known by teleorthodontics to help during the COVID-19 pandemic to remotely monitor patients'' conditions. The attitudes toward teleassistance in orthodontics, and in general, dentistry by respective dental care professionals, was investigated in several studies which confirmed it was as an effective alternative to in-office visits for several routine procedures and to make consultations more accessible to dentists and patients [23, 38] . doi = 10.3390/jcm9061891 id = cord-265605-32gy8w8b author = Matthews, Michael title = Development of a psychosocial intervention to support informal caregivers of people with end-stage kidney disease receiving haemodialysis date = 2020-10-01 keywords = carer; informal; study summary = The aim of this study is therefore to explore the experiences and unmet needs of informal carers of people with end-stage kidney disease receiving haemodialysis and develop a psychosocial intervention to support them in their caring role. The aim of this study is explore the experiences and unmet needs of informal carers of people with end-stage kidney disease receiving haemodialysis and develop a suitable psychosocial intervention to address their needs and support them in their caring role. The objectives of this study are to -To complete a systematic review of previous research related to experiences, needs, and interventions developed for informal carers of patients with end-stage kidney disease receiving haemodialysis. To hold a national workshop in order to share findings from the semi-structured interviews completed with informal carers and focus groups completed with healthcare professionals and so inform the development of a psychosocial intervention for informal carers of patients with end-stage kidney disease receiving haemodialysis. doi = 10.1186/s12882-020-02075-2 id = cord-341097-c96hm610 author = Mayer, Craig S. title = Analysis of data dictionary formats of HIV clinical trials date = 2020-10-05 keywords = CDISC; Data; HIV; study summary = To facilitate aggregation across studies, we defined three types of data dictionary (data element, forms, and permissible values) and created a simple information model for each type. The presented study is limited to data dictionary analysis, although the motivation is to later analyze a large body of past HIV data elements to inform data-driven consensus on CDEs. This study is part of a larger research project titled ''Identification of Research Common Data Elements in HIV/AIDS using data science methods'' [12] . We use the term Forms Data Dictionary (or forms dictionary in shorter form) to refer to a data dictionary that provides a full list of titles and descriptions of all Case Report Forms (CRFs) used in the study (or other relevant metadata for data element grouping). Use of categorical data elements in research is extremely common and, as stated earlier, most studies would be expected to provide a permissible value dictionary. doi = 10.1371/journal.pone.0240047 id = cord-267076-a4ulg4ck author = Mechili, Enkeleint A. title = Is the mental health of young students and their family members affected during the quarantine period? Evidence from the COVID‐19 pandemic in Albania. date = 2020-07-13 keywords = covid-19; student; study summary = AIM: This study aimed to assess the levels of depression among bachelor and master university students (nurses/midwives) and their family members'' during the quarantine period of COVID‐19 pandemic. Being unsatisfied with COVID‐19 prevention measures, beliefs that COVID‐19 infection and quarantine process can cause problems on their health status were the key factors for students to be screened positive for mental problems in multiple regression analysis. Therefore, given, the psychological burden caused by similar emergencies in the past, this study aimed to evaluate the levels of depression of students (nursing and midwifery) and their family members'' during the quarantine period. Both students and family members who considered that quarantine itself and COVID-19 can cause problems on their health were more likely to be have high levels of depression. This is the first study to measure the depression levels of nursing/midwifery students and their family members in Albania during the COVID-19 outbreak and quarantine period. doi = 10.1111/jpm.12672 id = cord-259012-rk0sd9i5 author = Mehta, Hemal title = Trends in Real-World Neovascular AMD Treatment Outcomes in the UK date = 2020-10-14 keywords = age; study summary = PURPOSE: To report trends in real-world outcomes of anti-vascular endothelial growth factor (anti-VEGF) therapy for neovascular age-related macular degeneration (nAMD) in the United Kingdom (UK) over the last decade. The following multipurpose (.mp) search terms and Medical Subject Headings (MeSH) terms where available were used: macular degeneration, age related macula degeneration, AMD, nAMD, neovascular, wet, VEGF, anti-VEGF, ranibizumab, Lucentis, aflibercept, Eylea, bevacizumab, Avastin, visual acuity, visual outcomes, vision, ocular, blindness, registry, database, long term study/studies, observational study/studies, Phase IV study/studies, real world, real-world, United Kingdom, UK, Scotland, Wales, Northern Ireland, England. Predicting visual outcomes in patients treated with aflibercept for neovascular age-related macular degeneration: data from a real-world clinical setting Impact of injection frequency on 5-year real-world visual acuity outcomes of aflibercept therapy for neovascular age-related macular degeneration Realworld visual and clinical outcomes for patients with neovascular age-related macular degeneration treated with intravitreal ranibizumab: an 8-year observational cohort (AMD8) doi = 10.2147/opth.s275977 id = cord-335109-czheponh author = Meidenbauer, Kimberly L. title = The Affective Benefits of Nature Exposure: What’s Nature Got to Do with It? date = 2020-09-18 keywords = Nat; STAI; Study; image summary = In one set of studies (Study 1 and 2), state affect before and after image viewing was examined as a function of both preference level (high, low, very high, or very low aesthetic value) and environment type (nature or urban). Despite work identifying preference as an influence in the emotional benefits of nature exposure (Mayer et al., 2009; Beute & de Kort, 2014; White et al., 2010; Browning et al., 2020) , many studies linking nature contact to psychological well-being do not assess preference for these environments, or examine how affect change relates to preference (Lee et al., 2009; Tsunetsugu et al., 2013; Valtchanov et al., 2010) . Additionally, to analyze the role of individual differences in preference for the images, a linear regression predicting change in affect by participants'' average preference rating (ignoring condition) was conducted (Analysis 5). doi = 10.1016/j.jenvp.2020.101498 id = cord-256145-4rcy64y8 author = Menzies-Gow, Andrew title = DESTINATION: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the long-term safety and tolerability of tezepelumab in adults and adolescents with severe, uncontrolled asthma date = 2020-10-21 keywords = LTE; destination; study summary = title: DESTINATION: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the long-term safety and tolerability of tezepelumab in adults and adolescents with severe, uncontrolled asthma DESTINATION is an ongoing phase 3, multicentre, randomized, double-blind, placebo-controlled, parallelgroup LTE study aiming to evaluate the long-term safety and tolerability of tezepelumab 210 mg administered subcutaneously (SC) every 4 weeks (Q4W) in adults (18-80 years old) and adolescents (12-17 years old) treatment cessation. DESTINATION aims to evaluate the long-term safety, tolerability and efficacy of tezepelumab compared with placebo in patients with severe, uncontrolled asthma who complete the NAVIGATOR or SOURCE predecessor studies and continue dosing for approximately 1 year. DESTINATION is an LTE study that is evaluating the long-term safety and tolerability of tezepelumab versus placebo, with continued dosing for approximately 1 year after patients with severe, uncontrolled asthma complete the phase 3 NAVIGATOR or SOURCE tezepelumab studies. doi = 10.1186/s12931-020-01541-7 id = cord-268088-y4vg7frb author = Montané, Xavier title = Current Perspectives of the Applications of Polyphenols and Flavonoids in Cancer Therapy date = 2020-07-23 keywords = acid; anticancer; apoptosis; cancer; cell; drug; effect; study summary = Among the natural compounds that produce beneficial effects on human health, polyphenols have shown potential therapeutic applications in cancer due to their protective functions in plants, their use as food additives, and their excellent antioxidant properties. This review shows a wide range of trials in which polyphenolic compounds play a crucial role as anticancer medicines alone or in combination with other drugs at different stages of cancer: cancer initiation, promotion, and growth or progression. In point of fact, studies demonstrated that resveratrol has in vitro effects against a large range of human tumors: breast, skin, ovary, stomach, prostate, colon, liver, pancreas, cervix, thyroid carcinoma cells, lymphoid, and myeloid cancer cells [22] . In point of fact, studies demonstrated that resveratrol has in vitro effects against a large range of human tumors: breast, skin, ovary, stomach, prostate, colon, liver, pancreas, cervix, thyroid carcinoma cells, lymphoid, and myeloid cancer cells [22] . doi = 10.3390/molecules25153342 id = cord-328979-xfze12ah author = Monto, Arnold S title = Data resource profile: Household Influenza Vaccine Evaluation (HIVE) Study date = 2019-04-30 keywords = HIVE; Study; influenza summary = Collecting specimens within a short time from the onset of symptoms still maximizes the likelihood of accurate and timely identification of viruses associated with a respiratory illness for studies of transmission and vaccine effectiveness. While respiratory virus infections in general could be studied, the primary objective was to estimate the effectiveness of influenza vaccines using a cohort design for comparison with studies using the testnegative design (TND). With additional funding, we have expanded on these original aims by collecting blood specimens for studies of antibody-mediated Households 328 213 321 232 340 227 Participants 1441 943 1426 1049 1431 996 Influenza-positive individuals 125 32 111 50 202 38 Influenza-positive specimens 130 32 117 52 210 40 Strain A c 86 23 69 48 166 30 H1N1pdm09 27 1 3 47 0 28 H3N2 59 22 66 1 immunity, extending ARI surveillance year-round, and incorporating laboratory testing for other respiratory viruses. doi = 10.1093/ije/dyz086 id = cord-342210-r8vxz5vu author = Mukherjee, Pranab K. title = Randomized, double-blind, placebo-controlled clinical trial to assess the safety and effectiveness of a novel dual-action oral topical formulation against upper respiratory infections date = 2017-01-14 keywords = arm; group; placebo; study summary = We conducted a randomized, double-blinded, placebo-controlled pilot clinical trial to evaluate the safety and efficacy of ARMS-I™ (currently marketed as Halo™) in the prevention of URIs. METHODS: ARMS-I is patented novel formulation for the prevention and treatment of influenza, comprising a broad-spectrum antimicrobial agent (cetylpyridinium chloride, CPC) and components (glycerin and xanthan gum) that form a barrier on the host mucosa, thus preventing viral contact and invasion. The primary objectives were to establish whether ARMS-I decreased the frequency, severity or duration of URIs. Secondary objectives were to evaluate safety, tolerability, rate of virus detection, acceptability and adherence; effect on URI-associated absenteeism and medical visits; and effect of prior influenza vaccination on study outcomes. In the current study, we evaluated the safety and effectiveness of ARMS-I, a novel intra-oral formulation in the prevention of URIs in a randomized, double-blind, placebo-controlled proof-of-concept clinical trial in healthy adults. doi = 10.1186/s12879-016-2177-8 id = cord-324859-0yuhb5dl author = Mulchandani, Rubina title = Deciphering the COVID‐19 cytokine storm: Systematic review and meta‐analysis date = 2020-11-02 keywords = COVID-19; IL-6; patient; study summary = In this context, we sought to undertake a systematic review and meta-analysis of available evidence to understand the pattern of host immune response in patients diagnosed with COVID-19 and how the levels of inflammatory and immunological markers vary according to the severity or stage of the disease. To understand the pattern of host immune response and summarize evidence for the difference in the levels of immunological and inflammatory biomarkers associated with cytokine storm, between COVID-19 patient groups of varying disease severity. Studies measuring the immunological and inflammatory indicators of cytokine storm in adult patients with a confirmed diagnosis of COVID-19, and comparing them between severe and non-severe (mild-moderate) cases, were eligible to be included in our review. Outcomes included circulating levels of interleukins (IL-6, IL-8, IL-10 and others depending on availability of estimates), tumour necrosis factor-alpha and T-lymphocyte counts (CD4+ T cells and CD8+ T cells) that have been widely reported in relation to the cytokine storm in patients having severe COVID-19. doi = 10.1111/eci.13429 id = cord-354491-23cjm86c author = Muller, A. E. title = The mental health impact of the covid-19 pandemic onhealthcare workers, and interventions to help them: a rapid systematic review date = 2020-07-04 keywords = COVID-19; July; healthcare; study; worker summary = Methods: We performed a rapid systematic review to identify, assess and summarize available research on the mental health impact of the covid-19 pandemic on healthcare workers. Discussion: Healthcare workers in a variety of fields, positions, and exposure risks are reporting anxiety, depression, sleep problems, and distress during the covid-19 pandemic, but most studies do not report comparative data on mental health symptoms. Six studies reported on the implementation of interventions to prevent or reduce mental health problems caused by the covid-19 pandemic among healthcare workers. While the majority of studies were cross-sectional and assessed as having high risk of bias, several patterns in their findings were evident: more healthcare workers were interested in social support to alieve mental health impacts, only a minority were interested in professional help for these problems, and yet interventions described in the literature largely seemed to focus on relieving individual symptoms. doi = 10.1101/2020.07.03.20145607 id = cord-264079-u0nkjexi author = Murphy, Dianne title = The use of gowns and masks to control respiratory illness in pediatric hospital personnel date = 1981-11-30 keywords = RSV; respiratory; study summary = title: The use of gowns and masks to control respiratory illness in pediatric hospital personnel Nosocomial disease often lengthens the hospital stay and, in some instances, may be severe or even fatal> ~ For certain viruses, particularly respiratory syncytial virus, there is a high frequency of infection in nursing, medical, and other stafP ..... Children with respiratory disease are usually placed in isolation and hospital personnel may be cohorted or required to wear gowns when administering patient care. The efficacy of this approach in the control of RSV therefore designed a prospective study to examine the effect of various control methods on the acquisition of symptomatic respiratory infections by medical personnel caring for infants with respiratory disease. We were unable to demonstrate any effect of adding the use of both gown and mask to the usual handwashing routine on the development of illness in personnel caring for infants with respiratory disease. doi = 10.1016/s0022-3476(81)80401-5 id = cord-151118-25cbus1m author = Murray, Benjamin title = Accessible Data Curation and Analytics for International-Scale Citizen Science Datasets date = 2020-11-02 keywords = Covid; Study; Symptom summary = To test the performance of the join operator when ExeTera and Pandas are used, we generate a dataset composed of a left primary key (int64), a right foreign key (int64) and 1, 2, 4, 8, 16 , and 32 fields respectively of random numbers corresponding to entries in the right table (int32). In this work, we present ExeTera, a data curation and analytics tool designed to provide users with a low complexity solution for working on datasets approaching terabyte scale, such as national / international-scale citizen science datasets like the Covid Symptom Study. ExeTera provides features for cleaning, journaling, and generation of reproducible processing and analytics, enabling large research teams to work with consistent measures and analyses that can be reliably recreated from the base data snapshots. Although ExeTera was developed to provide data curation for researchers working on the Zoe Symptom Study, this software is being developed to be generally applicable to large-scale relational datasets for researchers who work in Python. doi = nan id = cord-298265-elbnzgx6 author = Mutua, Victoria title = A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics date = 2020-08-01 keywords = PAD4; ROS; effect; extracellular; net; neutrophil; study; trap summary = Studies have demonstrated that circulating neutrophils of RA patients are more easily stimulated to NETosis than those from healthy subjects [73, 74] , and as in other autoimmune conditions, NETs act as a source of extracellular autoantigens leading to excessive innate and adaptive immune responses in the joints and subsequent tissue injury [73, 75] . Inhibits ROS production, prevents thrombus formation [190] [191] [192] [193] [194] [195] Nucleases Recombinant human DNase DNA matrixes Reduces neutrophil infiltration, cleaves DNA matrixes [196] [197] [198] [199] [200] [201] [202] [203] [204] [205] [206] [207] Staphylokinase Plasminogen, alpha-defensins Converting NETs to deoxyadenosine mediating death of immune cells [208] [209] [210] [211] Notable compounds Probiotics PKC pathway run a study to evaluate the effect of inhibition of PAD4 in NETosis using an antagomiR-155, a pleiotropic microRNA important in the regulation of immune responses, demonstrating a decreased induction of PAD4 mRNA and subsequent reduced NETs in response to PMA challenge [13] . doi = 10.1007/s12016-020-08804-7 id = cord-010977-fwz7chzf author = Myserlis, Pavlos title = Translational Genomics in Neurocritical Care: a Review date = 2020-02-20 keywords = RNA; TBI; disease; genomic; human; injury; model; stroke; study summary = In this review, we describe some of the approaches being taken to apply translational genomics to the study of diseases commonly encountered in the neurocritical care setting, including hemorrhagic and ischemic stroke, traumatic brain injury, subarachnoid hemorrhage, and status epilepticus, utilizing both forward and reverse genomic translational techniques. Termed "reverse translation," this approach starts with humans as the model system, utilizing genomic associations to derive new information about biological mechanisms that can be in turn studied further in vitro and in animal models for target refinement (Fig. 1) . These results highlight the value of reverse genomic translation in first identifying human-relevant genetic risk factors for disease, and using model systems to understand the pathways impacted by their introduction to select rationally-informed modalities for potential treatment. These observations provide vital information about cellular mechanisms impacted by human disease-associated genetic risk factors without requiring the expense and time investment of creating, validating, and studying animal models. doi = 10.1007/s13311-020-00838-1 id = cord-286075-yp2ta24o author = Nacul, Luis title = How Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Progresses: The Natural History of ME/CFS date = 2020-08-11 keywords = CFS; chronic; disease; fatigue; study; syndrome summary = We propose a framework for understanding and interpreting the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) that considers wider determinants of health and long-term temporal variation in pathophysiological features and disease phenotype throughout the natural history of the disease. The lack of progress in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) research has been attributed to a range of factors, including the paucity of large, high quality, hypothesis-driven studies, and controversy around diagnosis. Of note, many of the abnormalities shown in severe injury have also been identified in ME/CFS such as: immune dysfunction, including pro-inflammatory response (especially at early stages of disease) (45, 46); autonomic nervous system (47) (48) (49) ; HPA axis dysfunction (50); hypovolemia (51); nitrosamine and oxidative stress (52); endothelial dysfunction (52); metabolic dysfunction (53-55); dysfunction of membrane transport (56) ; and, tissue hypoxia (57). The UK ME/CFS biobank: a disease-specific biobank for advancing clinical research into myalgic encephalomyelitis/chronic fatigu syndrome doi = 10.3389/fneur.2020.00826 id = cord-320828-5ksho1bh author = Narchi, Hassib title = Nasopharyngeal Isolates from a Cohort of Medical Students with or without Pharyngitis date = 2020-10-05 keywords = Centor; study summary = Overall, the most common isolates were human rhinovirus, Streptococcus pneumoniae and Haemophilus influenzae, with no significant differences in terms of gender, year of study or stage of study. necrophorum were not detected among students with symptoms of pharyngitis; moreover, Centor scores of ≥2 were not associated with the presence of S. 15 Therefore, this study aimed to elucidate patterns of nasopharyngeal colonisation in a cohort of medical students with or without symptoms of pharyngitis, evaluate the performance of the Centor score in the diagnosis of S. pyogenes-positive samples were isolated from students with Centor scores of ≤2 (P = 1.000). influenzae was also very unlikely to have been a major cause of pharyngitis in the current study, given the lack of significant difference in its detection rate between symptomatic and asymptomatic participants. 16, 22 The PCR results of another study indicated that 10.3% of symptomatic patients and 1.1% of asymptomatic medical students were positive for S. doi = 10.18295/squmj.2020.20.03.007 id = cord-002705-ntokyoai author = Nasir, Nazrila Hairin title = Effectiveness of a fluid chart in outpatient management of suspected dengue fever: A pilot study date = 2017-10-04 keywords = dengue; fluid; study summary = doi = 10.1371/journal.pone.0183544 id = cord-329344-06uk5sjp author = Neumann-Podczaska, Agnieszka title = COVID 19 - Clinical Picture in the Elderly Population: A Qualitative Systematic Review date = 2020-07-23 keywords = covid-19; old; patient; study summary = In the following study, we constructed a systematic review to concisely summarize the clinical features, comorbidities, radiological/laboratory findings, and outcomes in the older adults. Only older individuals (≥60 years old) with confirmed SARS-CoV-2 infection were of interest in this review, hence any study that did not clearly separate the data according to this age bracket was excluded. Once the relevant studies were isolated, the two reviewers extracted the data independently into a standardized form with the following subheadings: paper Aging and Disease • Volume 11, Number 4, August 2020 990 information (such as publication date, number of patients, country, and gender), symptoms, comorbidities, laboratory findings, radiographic findings, complications, treatment, and outcome. Studies comparing data from solely dead vs discharged patients, were excluded from review estimation of mortality rate due to unclear total hospitalized elderly COVID-19 population [13, 25] . doi = 10.14336/ad.2020.0620 id = cord-335251-w6k4fnpo author = Nielsen, Morten Birkeland title = Organizational Prevention and Management Strategies for Workplace Aggression Among Child Protection Workers: A Project Protocol for the Oslo Workplace Aggression Survey (OWAS) date = 2020-06-30 keywords = aggression; study; workplace summary = The main objectives of the current project were to determine the impact of physical and psychological aggression on the well-being, health, and work ability of employees in the child welfare service and to establish whether a strong psychosocial safety climate and an ethical infrastructure are effective with regard to protecting employees against aggression. With previous research showing that a stressful working environment is a main cause of bullying and harassment (Hauge et al., 2007; Van den Brande et al., 2016) , employees in the child welfare service are also at increased risk of being exposed to aggression from co-workers. In this project, we will empirically examine the role of ethical infrastructure and psychosocial safety climate with regard to exposure to multiple forms of workplace aggression among child welfare workers. The questionnaire contains items and inventories that can be classified into the following five main categories: (1) demographics and background information; (2) physical and psychological aggression; (3) psychosocial safety climate and ethical infrastructure; (4) psychosocial work factors; and (5) health and well-being. doi = 10.3389/fpsyg.2020.01401 id = cord-294910-gnc04ax1 author = Nogueira, Paulo Jorge title = The Role of Health Preconditions on COVID-19 Deaths in Portugal: Evidence from Surveillance Data of the First 20293 Infection Cases date = 2020-07-24 keywords = COVID-19; SARS; kidney; study summary = The risk factors for increased odds of death by COVID-19 were: sex (male: OR = 1.47, ref = female), age ((56–60) years, OR = 6.01; (61–65) years, OR = 10.5; (66–70) years, OR = 20.4; (71–75) years, OR = 34; (76–80) years, OR = 50.9; (81–85) years, OR = 70.7; (86–90) years, OR = 83.2; (91–95) years, OR = 91.8; (96–104) years, OR = 140.2, ref = (0–55)), Cardiac disease (OR = 2.86), Kidney disorder (OR = 2.95), and Neuromuscular disorder (OR = 1.58), while condition (None (absence of precondition); OR = 0.49) was associated with a reduced chance of dying after adjusting for other variables of interest. The data retrieved include individuals'' demographic characteristics (age, sex, region), COVID-19 disease information (death, recovery, still in treatment, hospitalization, intensive care, respiratory support), and preconditions (Asthma, Cancer, Cardiac disease, Hematological disorder, Diabetes, HIV and other immune deficiency, Kidney disorder, Liver disorder, Neuromuscular disorder, Other precondition and None (absence of precondition)). doi = 10.3390/jcm9082368 id = cord-006864-t5qsjyfi author = Norris, S. title = National scientific medical meeting 1995 abstracts: Oral presentations date = 1995 keywords = group; patient; study summary = 28 patients with RA were studied prospectively by measuring disease activity and radiological articular destruction at entry and at review 6 (mean) (range 4-8) years later. We document its occurrence in the paediatric age group with 3 case reports of tinea unguium occurring in healthy children, ages ranging from 7 to 14 years from different families, presenting over a 6 month period. The first group (the study group, n=20) consisted of patients attending ophthalmic clinics with a diagnosis of early open angle glaucoma who are on medical treatment with good control of intraocular pressure, evidence of optic disc cupping and no field loss on KOWA fields. In this study, 12 outpatients having Dementia of the Alzheimer Type (Clinical Dementia Rating, Score ~ 1 ; mean age _+ SEM, 74 + 2 years) were continuously monitored using Finapress and their responses to the Valsalva manoeuvre and positional change were compared with 12 age matched (73 _+ 1 years) healthy elderly controls. doi = 10.1007/bf02967283 id = cord-025495-udz9i0fw author = Nowak, Jan K. title = Lithium and coronaviral infections. A scoping review. date = 2020-04-03 keywords = infection; lithium; study summary = The available evidence comes only from studies of cell cultures and indicates that lithium effectively inhibits coronaviral infections when administered at concentrations that are toxic to humans. "The available evidence comes only from studies of cell cultures and indicates that lithium effectively inhibits coronaviral infections when administered at concentrations that are toxic to humans." The prescription of lithium in the context of the current epidemic thus appears not to be supportable by the findings. Lithium also seemed to bring improvement in a proof-of-concept randomized double-blind placebo-controlled trial involving eleven healthy adults with recurrent HSV infections and in a randomized study of ten women with genital herpes conducted by the same research group from Philadelphia." Therefore it seems that in some instances lithium exhibits antiviral activity at concentrations, which are safe and maintained long-term (for years) in patients with affective disorders. The latter study gives hope that lithium may indeed be efficient at clinically relevant levels." In terms of discussion, the authors reviewed some existing literature and suggested a potential mechanism of reduced apoptosis by lithium, the glycogen synthase kinase 3-beta (GSK-3β) inhibitor. doi = 10.12688/f1000research.22299.2 id = cord-026990-d3l1sbeb author = Oberoi, Sumit title = Economic menace of diabetes in India: a systematic review date = 2020-06-17 keywords = India; cost; diabetes; study summary = Thus, the present study aims at capturing the evidence from the literature on the cost of diabetes mellitus in India, reviewing the materials and methods used to estimate the costs and, lastly, exploring future research area. Majority of research publications were excluded on the grounds if they (a) did not provide the detailed analysis of how costs were estimated; (b) were conference articles or posters; (c) only presented the costs of diabetes prevention; and (d) were published in non-peer-reviewed journals. (cost for patients with foot complication was ₹19,020/-, also average cost for renal patients Under the north zone, 8 studies were included to calculate both direct and indirect costs of diabetes at the individual/household level (Fig. 1) . Therefore, the findings of the present study suggest that per annum median direct and indirect cost of diabetes at the individual/household level is very colossal in India. doi = 10.1007/s13410-020-00838-z id = cord-294005-gjrj1gvr author = Odei Erdiaw-Kwasie, Michael title = Citizen participation dilemmas in water governance: An empirical case of Kumasi, Ghana date = 2020-12-31 keywords = GWCL; Ghana; governance; participation; study; water summary = Findings from the study show that citizens are willing to participate in decision-making on water-related process through radio programs; public meetings; surveys or polls and telephone. In line with the Ghana National Water Policy that aims to ensure full participation of all stakeholders in decision-making on water-related issues in realization of the Ghana Water Vision for 2025 [which states ''''promoting an efficient and effective management system and environmentally sound development of all water resources in Ghana"], the study''s focus is timely and relevant. With regard to this study, at the district/community level, key variables that were adopted in the interview and focus group discussion (FGD) instruments included the following: level of involvement in decision making, governance processes and the effects on citizens'' participation. A majority of respondents agreed that GWCL uses the following mechanisms in making decisions on participation approaches in water governance issues, radio programs, public meetings, surveys or polls, and telephone. doi = 10.1016/j.wdp.2020.100242 id = cord-025366-haf542y0 author = Offit, Paul A. title = Vaccine safety date = 2012-11-07 keywords = United; VAERS; adverse; immunization; risk; safety; study; vaccine summary = 147, 148 In the United States, the CDC established the Clinical Immunization Safety Assessment (CISA) network in 2001 with the following primary goals: (1) to develop research protocols for clinical evaluation, diagnosis, and management of adverse events following immunization (AEFI); (2) to improve the understanding of AEFI at the individual level, including determining possible genetic and other risk factors for predisposed persons and high-risk subpopulations; (3) to develop evidence-based algorithms for vaccination of persons at risk of serious adverse events following immunization; and (4) to provide a resource of subject matter experts for clinical vaccine safety inquiries. Third, large population-based systems that link computerized vaccination data with health care encounter codes were used to conduct rapid ongoing analyses to evaluate possible associations of H1N1 vaccination with selected adverse events, including potential associations suggested by VAERS or other sources. doi = 10.1016/b978-1-4557-0090-5.00076-8 id = cord-346098-gj10adoq author = Oh, Ga-Eun (Grace) title = When dessert comes close: The effects of anticipating indulgent consumption and dietary restraint on healthy food preference at restaurants date = 2020-07-16 keywords = Polivy; Study; eater; food; healthy summary = The findings suggest that, despite increasing concern for healthy eating, restrained consumers ironically show a preference for unhealthy food options when anticipating a dessert consumption opportunity. In the present study, to test our predictions for the interactive effect of indulgence anticipation and dietary restraint on healthy food preference, we focus on behavioral response measured by preference for or choice of healthy food for immediate consumption in restaurant settings. In the context of sequential consumption decisions (e.g., ordering a dessert after an entrée has been served and consumed in a restaurant) (Her and Seo, 2017) , prior research has shown that, despite restrained eaters'' concerns for weight control, when encountering challenges to dietary goals, they tend to forgo restraint goals and willingly consume indulgent food. Study 1 aims to test the different effects of anticipating future indulgence on the preference for healthy and unhealthy options among restrained versus unrestrained eaters (H1a; H1b). doi = 10.1016/j.ijhm.2020.102614 id = cord-344988-09vpehvf author = Overbeck, Silke title = Modulating the immune response by oral zinc supplementation: a single approach for multiple diseases date = 2008-02-05 keywords = cell; effect; immune; study; supplementation; zinc summary = Zinc supplementation in diseases such as diarrhea, chronic hepatitis C, shigellosis, leprosy, tuberculosis, pneumonia, acute lower respiratory infection, and leishmaniasis seems beneficial. Infection with the human immunodeficiency virus (HIV) results in the acquired immune deficiency syndrome (AIDS), a disease where zinc application was tested as a supporting therapeutic intervention [23] . [95] , there was no alteration of the CD4/CD8 ratio in the initial study [176] and several recent papers were unable to find effects of oral zinc on HIV-1 viral load, immune response to tuberculosis, lymphocyte subsets, CD4 + , CD8 + , and CD3 + cell counts, or antibody response to a pneumococcal conjugate vaccine [16, 27, 40, 54, 163] . Although this has not been directly investigated so far, the improvement in parameters for oxidative stress in diabetic patients indicates that the antioxidant effect of zinc is relevant for disease progression in vivo. doi = 10.1007/s00005-008-0003-8 id = cord-296491-467nrx6d author = O’Brien, Bridget C. title = Pause, Persist, Pivot: Key Decisions Health Professions Education Researchers Must Make About Conducting Studies During Extreme Events date = 2020-06-09 keywords = event; extreme; study summary = title: Pause, Persist, Pivot: Key Decisions Health Professions Education Researchers Must Make About Conducting Studies During Extreme Events Although at the time of this writing, the COVID-19 pandemic was the extreme event at hand, the authors intentionally created questions and discussed considerations that can be helpful for thinking through decisions in a variety of disruptions in health professions education research—many of which require similar difficult decisions and creative solutions to carry important research forward and maintain high quality. Although at the time of this writing, the COVID-19 pandemic was the extreme event at hand, the authors intentionally created questions and discussed considerations that can be helpful for thinking through decisions in a variety of disruptions in health professions education research-many of which require similar difficult decisions and creative solutions to carry important research forward and maintain high quality. • Will need to change-I will adjust recruitment, data collection procedures, survey/interview/focus group questions, analysis: Persist or pivot doi = 10.1097/acm.0000000000003535 id = cord-022219-y7vsc6r7 author = PEIFFER, ROBERT L. title = Animals in Ophthalmic Research: Concepts and Methodologies date = 2013-11-17 keywords = Fig; IOP; animal; cell; cornea; eye; lens; model; ocular; rabbit; retinal; study; technique; tissue summary = doi = 10.1016/b978-0-12-278006-6.50008-2 id = cord-285898-rtqkvf63 author = Padberg, Stephanie title = Anti-infective Agents date = 2014-09-29 keywords = Antiretroviral; HIV; Pregnancy; Registry; exposure; risk; section; study; treatment; trimester; woman summary = In the case of clarithromycin, there was some 2.6 Anti-infective Agents 2 Pregnancy initial concern as animal experiments demonstrated teratogenic effects, and for instance, in some studies cardiovascular defects were induced in rats. In a prospective cohort study with 949 women who were exposed to a fluorquinolone during the first trimester, neither the rate of major birth defects, nor the risk of spontaneous abortion were increased compared to a control group (Padberg 2014) . Danish cohort studies based on a prescription register also could not find an increased risk of birth defects after first trimester exposure in several thousand pregnant women (Nørgaard 2008 , Sørensen 1999 ). Data from the Antiretroviral Pregnancy Registry (2013) with 27 birth defects in 905 cases, indicate a malformation rate of 3.0% after exposure during the first trimester, similarly as seen in the general population of the USA. Three birth defects were observed among 141 pregnant women with first trimester exposures reported to the Antiretroviral Pregnancy Registry (2013). doi = 10.1016/b978-0-12-408078-2.00007-x id = cord-300465-19euup51 author = Paniagua-Avila, Alejandra title = Evaluating a multicomponent program to improve hypertension control in Guatemala: study protocol for an effectiveness-implementation cluster randomized trial date = 2020-06-09 keywords = Health; hypertension; study summary = This study will generate urgently needed data on effective, adoptable, and sustainable interventions and implementation strategies to improve hypertension control in Guatemala and other LMICs. TRIAL REGISTRATION: ClinicalTrials.gov: NCT03504124. Specifically, these strategies include team-based care, health coaching sessions, home-based blood pressure (BP) monitoring, clinical decision support, BP audit and feedback, and training of healthcare providers. This study is an implementation-effectiveness, hybrid, type 2, cluster randomized control trial that will evaluate a multilevel and multicomponent hypertension control program within the Guatemalan primary care system [17] . The multicomponent program includes a protocol-based hypertension treatment and five implementation strategies: team-based collaborative care, health provider education, health coaching sessions, home blood pressure monitoring, and blood pressure audit and feedback. The overarching aim of this study is to evaluate the clinical effectiveness and implementation outcomes of a hypertension control multicomponent program within the first and second levels of care in Guatemala, compared to usual care. doi = 10.1186/s13063-020-04345-8 id = cord-007818-jfp9uumb author = Papali, Alfred title = Infrastructure and Organization of Adult Intensive Care Units in Resource-Limited Settings date = 2019-02-09 keywords = Ebola; ICU; care; intensive; oxygen; patient; resource; setting; study summary = Finally, so-called telemedicine in ICUs in resource-rich settings, mainly to solve the problem of physician shortages during nighttime hours and in some ICUs with low-intensity staffing [21] , has been shown to improve early identification of patients who deteriorate [22] and increases the number of interventions [23] , but the effect on ICU outcomes remains controversial [24] and costs of required technological infrastructure are high [25] . Despite the availability of specialty training programs in selected countries, regional data and the experience of the authors suggest that intensive care specialists are unavailable in many ICUs in resource-limited settings [40] . Dedicated courses in trauma and intensive care-and emergency medicine-related procedures improve knowledge in "best clinical practice" of healthcare professionals working in ICUs in resource-limited settings [56, 57] . doi = 10.1007/978-3-030-03143-5_3 id = cord-288052-qfjet2sa author = Paparini, Sara title = Case study research for better evaluations of complex interventions: rationale and challenges date = 2020-11-10 keywords = case; research; study summary = Empirical case studies typically enable dynamic understanding of complex challenges and provide evidence about causal mechanisms and the necessary and sufficient conditions (contexts) for intervention implementation and effects. For example, in an empirical case study of how the policy of free bus travel had specific health effects in London, UK, a quasi-experimental evaluation (led by JG) identified how important aspects of context (a good public transport system) and intervention (that it was universal) were necessary conditions for the observed effects, thus providing useful, actionable evidence for decisionmakers in other contexts [17] . If evaluative health research is to move beyond the current impasse on methods for understanding interventions as interruptions in complex systems, we need to consider in more detail how researchers can conduct and report empirical case studies which do aim to elucidate the contextual factors which interact with interventions to produce particular effects. doi = 10.1186/s12916-020-01777-6 id = cord-340284-xo7q4dqr author = Pappa, Sofia title = Prevalence of depression, anxiety, and insomnia among healthcare workers during the COVID-19 pandemic: A systematic review and meta-analysis date = 2020-05-08 keywords = covid-19; prevalence; study summary = The aim of this rapid systematic review and meta-analysis is to examine the emerging evidence of the effects of the COVID-19 outbreak on the mental health of HCW and particularly in relation to the prevalence of anxiety, depression and insomnia. Following search terms were used: ("healthcare workers" OR "medical staff" OR "healthcare professionals") AND ("coronavirus" OR "SARS-COV-2" OR "COVID-19") AND ("depression" OR "anxiety" OR "insomnia" OR "mental health" OR "psychological"). The following data were extracted from each article by two reviews independently: study type, total number of participants, participation rate, region, percentage of physicians, nurses and other HCWs screened in the survey, number of male and female participants, assessment methods used and their cut-offs as well as the total number and percentage of participants that screened positive for depression, anxiety or insomnia. This timely rapid systematic review and meta-analyses of 13 cross-sectional studies and a total of 33062 participants provides early evidence that a high proportion of healthcare professionals experience significant levels of anxiety, depression and insomnia during COVID-19 pandemic. doi = 10.1016/j.bbi.2020.05.026 id = cord-010680-lc1onm53 author = Patel, Ami title = In Vivo Delivery of Nucleic Acid-Encoded Monoclonal Antibodies date = 2020-03-10 keywords = AAV; RNA; antibody; delivery; dna; expression; study summary = Some of these hurdles may be overcome through transient in vivo gene delivery platforms, such as non-viral synthetic plasmid DNA and messenger RNA vectors that are engineered to encode optimized mAb genes. In this review, we focus on nucleic acid delivery of antibody employing synthetic plasmid DNA vector platforms, and RNA delivery, these being important approaches that are advancing simple, rapid, in vivo expression and having an impact in animal models of infectious diseases and cancer, among others. The original studies surrounding in vivo antibody gene delivery focused primarily on gene delivery using recombinant viral vectors such as AAV and adenovirus (Ad), which were advanced clinically, building on work in the traditional gene therapy-based field. Additional studies to help evaluate fully human pDNA-mAbs in mouse models would be highly informative for both non-viral and viral delivery and provide an important path forward for preclinical evaluation of in vivo-delivered antibodies [109] . doi = 10.1007/s40259-020-00412-3 id = cord-320851-zhf8jdcl author = Patil, Satish title = Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts date = 2015-11-24 keywords = Triptolide; prodrug; solution; study; tumor summary = title: Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts In a mouse model of human colon adenocarcinoma (HT-29), the prodrug administered intraperitoneally was effective in reducing or eliminating xenograft tumors at dose levels as low as 0.3 mg/kg when given daily and at 0.9 mg/kg when given less frequently. A nontoxic, water-soluble, chemically stable, and patentable prodrug approach would be a viable option to overcome some of the physicochemical limitations of triptolide for the clinical development of this natural product. Therefore, the prerequisites for a novel prodrug strategy of triptolide were three-fold: enhanced aqueous solubility, chemical stability, and fast, complete bioconversion in vivo. 46−49 We are now describing an improved synthesis for 4, its physicochemical characterization, and its pharmacodynamic evaluation in human colon adenocarcinoma and ovarian cancer xenografts via intraperitoneal and oral routes and using less frequent dosing schedules than employed in previous studies. doi = 10.1021/acs.jmedchem.5b01329 id = cord-354306-zbkgabl2 author = Pennycook, Gordon title = Fighting COVID-19 Misinformation on Social Media: Experimental Evidence for a Scalable Accuracy-Nudge Intervention date = 2020-06-30 keywords = COVID-19; F(1; Study; headline summary = In Study 1, participants were far worse at discerning between true and false content when deciding what they would share on social media relative to when they were asked directly about accuracy. According to this account, people generally wish to avoid spreading misinformation and, in fact, are often able to tell truth from falsehood; however, they nonetheless share false and misleading content because the social media context focuses their attention on factors other than accuracy (e.g., partisan alignment). In support of this inattention-based account, recent findings showed that most participants were surprisingly good at discerning between true and false political news when asked to assess "the accuracy of headlines"-yet headline veracity had very little impact on participants'' willingness to share the headlines on social media. Study 1 tested for a dissociation between accuracy judgments and sharing intentions when participants evaluated a set of true and false news headlines about COVID-19. doi = 10.1177/0956797620939054 id = cord-327967-cuy254tf author = Pierce John, P. title = Real-world exposure to graphic warning labels on cigarette packages in US smokers: The CASA randomized trial protocol date = 2020-09-20 keywords = Aim; GWL; Pack; cigarette; study summary = The study uses a blank pack (devoid of all advertising) as one control group for GWL packs to identify whether differences observed are from removing tobacco industry advertising or from using GWLs. We assess initial participant appeal-aversion responses to the study packaging to explore whether upfront reactivity modifies any downstream GWL effects. To test the effect of 3 months of real-world exposure to different cigarette packaging (Blank Pack devoid of any cigarette branding and GWL Pack featuring 1 of 3 rotating images) on smokers" cognitions and behavior about smoking at the end of the intervention exposure as well as longer term after smokers have reverted to their industry-marketed US packs. Aim 1: Assess changes in the perceptions (awareness, concern) of risks from cigarette smoking Aim 2: Assess changes in perceptions of appeal of cigarette packs and their subjective reinforcing effects on smoking Aim 3: Assess changes in cigarette smoking behavior including purchasing behavior, pack handling, quitting cognitions and cigarette consumption Aim 4 (Exploratory): Test whether the participants initial appeal-aversion response to the study pack designs as well as nicotine dependence modify responses to the 3-month intervention. doi = 10.1016/j.cct.2020.106152 id = cord-313783-cfcfiyju author = Pinna, Fábio de Rezende title = Olfaction and COVID: The little we Know and what else we need to know date = 2020-06-15 keywords = study summary = Recently, there have been numerous reports in the media that anosmia occurs in patients who have contracted coronavirus disease 2019 by exposure to the SARS-COV-02 virus. Another study from Europe hypothesized that olfactory disturbances could be highly associated with mild or moderate cases, even with a small sample size. [1] [2] [3] [4] Future studies should clarify whether this chemosensory loss differs according to COVID-19 severity or hospitalized and non-hospitalized patients. Regarding pathophysiology, the severe inflammation due to virus infection still needs better understanding, and maybe autopsies of patients who died could compare tissue damage between the olfactory epithelium and the bulb. This may be the underlying mechanism for reported cases of smell dysfunction in patients with COVID 19. Olfactory and gustatory dysfunctions as a clinical presentation of mild-tomoderate forms of the coronavirus disease (COVID-19): a multicenter European study Association of chemosensory dysfunction and Covid-19 in patients presenting with influenza-like symptoms doi = 10.1055/s-0040-1713143 id = cord-022594-fx044gcd author = Pirko, Istvan title = Demyelinating Disorders of the Central Nervous System date = 2009-05-18 keywords = ADEM; CNS; CSF; Devic; EDSS; MRI; NMO; lesion; multiple; patient; relapse; study summary = If a patient presents with a history of two or more attacks, but objective clinical evidence only suggests one lesion, the following additional data is needed to confirm the diagnosis: the disease process has to be disseminated in space as demonstrated by MRI; alternatively, two or more MRI-detected lesions consistent with MS plus positive CSF would suffice to meet the newly defined criteria. The EBM calculations regarding this trial show an RRR of 24%, and ARR of 11%, and an NNT of 9 patients over 2 years in order to prevent one conversion to "clinically definite MS." These two studies provide support for considering early treatment in patients presenting with first attack, in the presence of multiple asymptomatic MRI lesions, but further studies are needed to determine whether this approach will provide a prolonged benefit on disease course. doi = 10.1016/b978-141603618-0.10048-7 id = cord-328056-y5x80tuw author = Popescu, Corneliu P. title = Hydroxychloroquine-azithromycin for COVID-19 – Warranted or dangerous? date = 2020-05-30 keywords = study summary = (4) The seeming safety and effectiveness of hydroxychloroquine-azithromycin is in contradiction to data in a study published just a week earlier that showed dangerously increased death rates in hydroxychloroquine, chloroquine, and macrolide-treated patients.(5) That multi-nation registry of 96,032 hospitalized SARS-CoV-2 patients in 671 centers on six continents included 14,888 who were treated with chloroquine or hydroxychloroquine, with or without a macrolide.(5) Confounding factors were considered, and patients receiving remdesivir were excluded from the study. Widespread use of incompletely tested medications could potentially have dangerous side effects, and Million''s group wisely did not include patients with identified risk for arrhythmia in their study. While some readers will be encouraged enough by the results of Million''s study to "just do something" in giving hydroxychloroquine-azithromycin combined treatment to COVID-19 patients, others will opt to await more "proof" of safety and efficacy from randomized blinded controlled clinical trials. doi = 10.1016/j.tmaid.2020.101764 id = cord-004515-x22q1f21 author = Pottecher, Julien title = Protocol for TRAUMADORNASE: a prospective, randomized, multicentre, double-blinded, placebo-controlled clinical trial of aerosolized dornase alfa to reduce the incidence of moderate-to-severe hypoxaemia in ventilated trauma patients date = 2020-03-18 keywords = ARDS; ICU; dna; patient; study; trauma summary = doi = 10.1186/s13063-020-4141-6 id = cord-252691-757mh2mh author = Pratt, R. J. title = epic2: National Evidence-Based Guidelines for Preventing Healthcare-Associated Infections in NHS Hospitals in England date = 2007-02-28 keywords = BSI; CVAD; HCAI; HICPAC; Health; catheter; evidence; infection; study summary = Following extensive consultation, they were published in January 2001.1 These guidelines describe the precautions healthcare workers should take in three areas: standard principles for preventing HCAI, which include hospital environmental hygiene, hand hygiene, the use of personal protective equipment, and the safe use and disposal of sharps; preventing infections associated with the use of short-term indwelling urethral catheters; and preventing infections associated with central venous catheters. epic2: Guidelines for Preventing Healthcare-Associated Infections in NHS Hospitals S15 Current evidence-based guidelines conclude that in both outbreak and non-outbreak situations contaminated hands are responsible for crosstransmission of microorganisms and that effective and effective hand decontamination can significantly reduce both cross-transmission and crossinfection rates for the majority of HCAI in all healthcare settings. 1, 85 The decision to use or wear personal protective equipment must be based upon an assessment of epic2: Guidelines for Preventing Healthcare-Associated Infections in NHS Hospitals S19 the level of risk associated with a specific patient care activity or intervention and take account of current health and safety legislation. doi = 10.1016/s0195-6701(07)60002-4 id = cord-323910-lms3xw4k author = Putman, Michael title = Antirheumatic Disease Therapies for the Treatment of COVID‐19: A Systematic Review and Meta‐analysis date = 2020-08-02 keywords = COVID-19; cohort; patient; study summary = In this systematic review and meta-analysis, we identified and summarized published and pre-print original scientific articles that described the use of antirheumatic disease therapies for the treatment of COVID-19. The final eligibility criteria were (1) Included 5 or more people infected with SARS-CoV-2; (2) antirheumatic disease therapy (Supplemental Appendix); (3) published after January 1st, 2019; (4) original research; (5) had one of the following outcomes: Death, ventilator-free days, escalation of care (ICU transfer), length of hospital stay, symptom resolution, viral clearance. For reporting purposes and due to the methodological diversity of the studies, we prioritized results for summary and synthesis based on study design (RCT > cohort studies > case series), risk of bias assessment (low risk > some concerns > high risk) and relevance of the outcome (e.g. mortality > viral clearance). All rights reserved DISCUSSION In this systematic review and meta-analysis of antirheumatic disease therapies for the treatment of COVID-19, the use of hydroxychloroquine was not associated with mortality. doi = 10.1002/art.41469 id = cord-337663-ow1l18li author = Qu, Liang G. title = Scoping review: hotspots for COVID-19 urological research: what is being published and from where? date = 2020-09-09 keywords = COVID-19; Italy; SARS; study summary = This comprehensive review aimed to: identify all up-to-date original publications relating to urology and COVID-19, characterise where publications were from, and outline what topics were investigated. Topics of the study included pathophysiological, administrative, and clinical fields: translational (n = 14), COVID-19-related outcomes (n = 5), urology training (n = 4), telemedicine (n = 7), equipment and safety (n = 2), urology in general (n = 4), uro-oncology (n = 3), urolithiasis (n = 1), and kidney transplantation (n = 8). A registered study in France (NCT04341714) is similarly assessing the efficiency and satisfaction of telemedicine consults, aiming to recruit 400 patients from a neuro-urology clinic. 48 studies were included, investigating pathophysiological, administrative, and clinical outcomes relating to COVID-19 and urology. Clinical fields of COVID-19-related urological research seem to focus on uro-oncology, urolithiasis, and kidney transplant recipients. Nevertheless, our review is the first to provide a comprehensive country-level analysis of current original urological research related to COVID-19. doi = 10.1007/s00345-020-03434-2 id = cord-302833-6kntd89t author = Radonovich, Lewis J. title = The Respiratory Protection Effectiveness Clinical Trial (ResPECT): a cluster-randomized comparison of respirator and medical mask effectiveness against respiratory infections in healthcare personnel date = 2016-06-02 keywords = N95; infection; respiratory; study summary = BACKGROUND: Although N95 filtering facepiece respirators and medical masks are commonly used for protection against respiratory infections in healthcare settings, more clinical evidence is needed to understand the optimal settings and exposure circumstances for healthcare personnel to use these devices. Healthcare personnel who work in outpatient settings will be cluster-randomized to wear N95 respirators or medical masks for protection against infections during respiratory virus season. Abbreviations ARI, acute respiratory illness; CDC, centers for disease control and prevention; DSMB, data safety monitoring board; HAI, hemagglutination inhibition antibody; HCP, healthcare personnel; ILI, influenza like illness; LCRI, Laboratory confirmed respiratory illness; MM, medical mask; N95, N95 respirator; NIOSH, National Institute for Occupational Safety and Health; OSHA, Occupational Safety and Health Administration; PPE, occupational protective equipment; ResPECT, respiratory protection effectiveness clinical trial; RPD, respiratory protective devices; RT-PCR, reverse-transcriptase polymerase chain reaction; US, United States. doi = 10.1186/s12879-016-1494-2 id = cord-258399-difauneh author = Rahmani, Amir Masoud title = Coronavirus disease (COVID-19) prevention and treatment methods and effective parameters: A systematic literature review date = 2020-10-22 keywords = COVID-19; SLR; disease; method; study summary =  Providing a new-of-the-art taxonomy tree for evaluating the issue based on three baseline fields of treatment, and prevention facing methods, and the effective parameters in the COVID-19 outbreak  Providing a systematic literature review based on the proposed taxonomy tree  Covering detection, prediction, and management approaches against the disease according to three heads of treatment, prevention, and effective parameters  Supporting future scopes according to economic damages, treatment''s injuries, and people''s physical and mental damages after recovery and regarding social distancing''s rules in post-pandemic This tree covers the heads of all studies in the domain of the issue to investigate the effective parameters in the virus outbreak (Individual, ethnic, cultural, and social habits and environmental factors), prevention and detection''s role in facing the disease, and various therapies'' impact on improving patients'' with COVID-19 considering the treatment''s injuries. doi = 10.1016/j.scs.2020.102568 id = cord-295806-imuk73xa author = Ramirez-Moreno, J. M. title = Mask-associated de novo headache in healthcare workers during the Covid-19 pandemic. date = 2020-08-11 keywords = headache; mask; study summary = self-filtering masks of particles and liquid aerosols (FFP), average number of hours of use per day) and use of other protective devices (glasses or screens); (4) frequency and characteristics of pre-existing primary headache (changes in headache frequency, attack duration and frequency, as well as drug use and response), (5) the main variable of the study was personal opinion about the presence of new headache in the period in which these protective systems were mandatory (duration of headache episode, intensity and frequency, as well as drug use and response); (6) presence of other symptoms potentially associated with the use of facial protection equipment (fatigue, sleep disorder, lack of concentration, irritability, nausea or vomiting or others); (7) we evaluated the selfperceived impact of the presence of new-onset headache using the Likert scale on social, occupational, family and personal aspects; (8) we also evaluated the self-perceived impact that headache conditions have on the performance of work activities and (9) lastly, we analyzed self-perceived work stress by means of the Psychosomatic Problems Questionnaire (PPQ) [13] . doi = 10.1101/2020.08.07.20167957 id = cord-311260-eyvaazfj author = Rao, Ghanta N. title = Refinement of long-term toxicity and carcinogenesis studies() date = 2004-09-27 keywords = animal; chemical; study summary = journal: Fundam Appl Toxicol We must continue to strive to find species and strains that can metabolize chemicals similar to humans, are small enough to be housed in large numbers, and have low prevalence of spontaneous lesions with sufficient life span to express the toxic and carcinogenic potential of chemicals. We must continue to strive to find species and strains that can metabolize chemicals similar to humans, are small enough to be housed in large numbers, and have low prevalence of spontaneous lesions with sufficient life span to express the toxic and carcinogenic potential of chemicals. However, viral infections were associated with nonneoplastic lesions in lungs, nasal cavity, liver, and other organs of rats and mice and may complicate the identification and interpretation of toxic effects of chemicals (NTP, unpublished data). doi = 10.1016/0272-0590(90)90160-l id = cord-318092-errwp80i author = Ren, L. title = Assessment of Hydroxychloroquine and Chloroquine Safety Profiles: A Systematic Review and Meta-Analysis date = 2020-05-08 keywords = HCQ; figure; study summary = Methods: We systematically searched PubMed, MEDLINE, Cochrane, the Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, and the ClinicalTrials.gov for all the RCTs comparing CQ or HCQ with placebo or other active agents, published before March 31, 2020. Our objective was to identify all randomized clinical trials (RCTs) that compared the safety profiles of chloroquine or hydroxychloroquine with placebo or other active agents. This review was not restricted to studies conducted in the English language; it includes reports from any countries that compared CQ or HCQ with placebo or other active agents, since there is a wealth of information in RCTs from many different countries. Together, these stratified data provide ample information regarding the percentage of participants who experienced specific AEs. Subgroup meta-analysis for CQ and HCQ with respect to age, duration, and dosage. For HCQ, there was no evidence that age, duration of trial, or dosage affected total AEs. Further meta-regression analyses can be found in Supplementary Figure 1 . doi = 10.1101/2020.05.02.20088872 id = cord-324006-y4bd38zz author = Rishu, Asgar H. title = Time required to initiate outbreak and pandemic observational research()() date = 2017-03-01 keywords = REB; study; time summary = MATERIALS AND METHODS: At 1 pediatric and 5 adult intensive care units, we measured durations from protocol receipt to a variety of outbreak research milestones, including research ethics board (REB) approval, data sharing agreement (DSA) execution, and patient study screening initiation. Severe acute respiratory syndrome [5] ; pandemic influenza A (H1N1) 2009-2010 [6] ; and, more recently, Ebola virus [7] , MERS-CoV [8] , and Zika virus have been characterized by challenges initiating observational research and a near inability to rapidly undertake interventional trials necessary to inform best practice and improve care of patients [9] [10] [11] . However, conducting studies and trials involves time-consuming start-up steps such as development of study protocol, establishing a budget and obtaining funding, research ethics board (REB) approval, organizing multisite collaboration, and data sharing agreements. doi = 10.1016/j.jcrc.2017.02.009 id = cord-314908-kp2jznwb author = Roczniewska, Marta title = I believe I can craft! introducing Job Crafting Self-Efficacy Scale (JCSES) date = 2020-08-10 keywords = JCSE; Study; craft; job; table summary = To better predict these behaviors, we introduce the concept of job crafting self-efficacy (JCSE) and define it as an individual''s beliefs about their capability to modify the demands and resources of their job to better fit their needs. In this project we integrate Social Cognitive Theory and the Job Demands-Resources model [6, 7] to introduce the concept of job crafting self-efficacy (JCSE). Based on the assumptions of Social Cognitive Theory, we also expect that these specific beliefs predict matching job-crafting behaviors, for example, individuals who feel self-efficacious with respect to increasing challenging job demands are more likely to start new projects or learn about new developments at work and try them out. doi = 10.1371/journal.pone.0237250 id = cord-274597-a67u1elx author = Röseler, Lukas title = Evidence against subliminal anchoring: Two close, highly powered, preregistered, and failed replication attempts date = 2020-10-16 keywords = Englich; Mussweiler; anchor; study summary = Apart from anchors and the target question, the only other difference between Mussweiler and Englich''s Studies 1 and 2 was the prime detection task in Study 2, in which participants tried to recognize the subliminally presented anchor. To facilitate a power analysis, we pooled the effect sizes of the original Studies 1 and 2 (which differed only with respect to the target question) and found a mean effect of d = 0.69 (N = 76, 95% CI = [0.23, 1.16] , N min95% = 94) of subliminal anchoring. We defined the replication attempt as successful if both of the following criteria were met: (a) The effect of the subliminal anchors was significantly larger than 0, and (b) the effect was not significantly smaller than the original effect [for the sake of precision, we pooled Mussweiler & Englich''s, 2005 effect sizes from Studies 1 and 2, d = 0.69]. doi = 10.1016/j.jesp.2020.104066 id = cord-011952-mm06uzxx author = Rücker, Gerta title = The statistical importance of a study for a network meta-analysis estimate date = 2020-07-16 keywords = NMA; study summary = BACKGROUND: In pairwise meta-analysis, the contribution of each study to the pooled estimate is given by its weight, which is based on the inverse variance of the estimate from that study. For network meta-analysis (NMA), the contribution of direct (and indirect) evidence is easily obtained from the diagonal elements of a hat matrix. For NMA, while several methods exist to obtain the contribution of direct (and indirect) evidence of each comparison to its own NMA estimate, it is far less obvious how to define the contribution, or the importance, of each study to any (other) treatment effect estimate. In this paragraph, we show how our definition of importance was motivated by (but is not limited to) the known concepts of direct and indirect evidence proportions in the context of two-stage meta-analysis with inverse variance weights, still based on the common effect model. doi = 10.1186/s12874-020-01075-y id = cord-282063-tkp1tifx author = Saberi, Parya title = Research in the Time of Coronavirus: Continuing Ongoing Studies in the Midst of the COVID-19 Pandemic date = 2020-04-18 keywords = HIV; research; study summary = Some examples of social media to advertise and recruit participants include: social networks (such as Facebook, Instagram, and Twitter), dating apps (Grindr, Scruff, and Jack''d), and online listservs for various medical societies or health conditions. Study assessments can be conducted via online surveys which can be emailed or text messaged to participants. In cases of limited literacy, research staff can read questions to study participants or use survey platforms that include the ability to audio-record questions. Telehealth and texting intervention to improve HIV care engagement, mental health and substance use outcomes in youth living with HIV: a pilot feasibility and acceptability study protocol WYZ: a pilot study protocol for designing and developing a mobile health application for engagement in HIV care and medication adherence in youth and young adults living with HIV Real-Time and Wireless Assessment of Adherence to Antiretroviral Therapy With Co-Encapsulated Ingestion Sensor in HIV-Infected Patients: A Pilot Study doi = 10.1007/s10461-020-02868-4 id = cord-309122-9dfyjpid author = Sato, Akiko title = Reviews on common objectives and evaluation indicators for risk communication activities from 2011 to 2017 date = 2020-08-25 keywords = Health; communication; risk; study summary = Risk communication should: (i) promote awareness and understanding of the specific issues under consideration during the risk analysis; (ii) promote consistency and transparency in formulating risk management options/recommendations; (iii) provide a sound basis for understanding the risk management decisions proposed; (iv) improve the overall effectiveness and efficiency of the risk analysis; (v) strengthen the working relationships among participants; (vi) foster public understanding of the process, so as to enhance trust and confidence in the safety of the food supply; (vii) promote the appropriate involvement of all interested parties ; and (viii) exchange information in relation to the concerns of interested parties about the risks associated with food. The authors of this study identified ''''knowledge increase,'''' ''''change in risk perception and concern alleviation,'''' and ''''decision making and behavior change'''' as areas of focus in all fields; these objectives are also discussed in the definitions and purposes of most organizations and agencies (Fig. 2, Table 1 ). doi = 10.7717/peerj.9730 id = cord-262780-ilu5oskk author = Sattui, Sebastian E. title = Swinging the pendulum: lessons learned from public discourse concerning hydroxychloroquine and COVID-19 date = 2020-08-11 keywords = COVID-19; HCQ; Hydroxychloroquine; patient; study summary = The use of chloroquine (CQ) and hydroxychloroquine (HCQ) for COVID-19 exemplifies the risks of both overinterpreting and amplifying preliminary data by those outside of the scientific community and was followed by swift corrective measures by researchers. By early March, interest in HCQ abruptly transitioned from mechanistic plausibility that would support its study in a clinical trial setting to rapid off-label use in patients with COVID-19, primarily fueled by promotion on social media, lay press, and celebrity influence [8] . By late March, two new studies became publicly available: a second study from the group of IHU-Méditerranée Infection using HCQ and AZM in 80 patients with mild COVID-19 infection released on their webpage, and a preprint of the first randomized controlled trial of 62 patients from Wuhan reporting a difference in clinical time to recovery and radiologic findings with HCQ treatment [22, 23] . doi = 10.1080/1744666x.2020.1792778 id = cord-004636-t6qldq3s author = Saugel, Bernd title = Journal of Clinical Monitoring and Computing end of year summary 2019: hemodynamic monitoring and management date = 2020-03-14 keywords = PPV; ROC; SAP; patient; pressure; study summary = doi = 10.1007/s10877-020-00496-w id = cord-303300-89v1weno author = Sauter, Marian title = Building, Hosting and Recruiting: A Brief Introduction to Running Behavioral Experiments Online date = 2020-04-24 keywords = experiment; online; study; table summary = The critical procedural pillars of any behavioral study are: (1) programming an experiment in the preferred software (e.g., E-prime, PsychoPy, PsychToolbox, etc.); (2) setting-up the testing machine (e.g., lab-computer, multi-unit testing facility, etc.) and (3) recruiting participants to conduct the study. In comparison to the hegemony of Java, Python, C++ and MATLAB libraries for experimental programming of lab-based studies, Javascript (JS) is the language of choice for online experiments. In comparison to the hegemony of Java, Python, C++ and MATLAB libraries for experimental programming of lab-based studies, Javascript (JS) is the language of choice for online experiments. Generally speaking, what researchers need for online experimentation is the same as what they need for lab-based studies (Figure 1) : (1) a programmed experiment, (2) a server to host the study and (3) a recruiting platform which advertises to participants. The Timing Mega-Study: Comparing a Range of Experiment Generators, Both Lab-Based and Online doi = 10.3390/brainsci10040251 id = cord-356116-c40e3zp7 author = Savory, Eric title = Western Cold and Flu (WeCoF) aerosol study – preliminary results date = 2014-08-23 keywords = PIV; cough; particle; study summary = FINDINGS: A novel experimental cough chamber facility – the FLUGIE – has been developed to study the far-field aerodynamics and aerosol transport of droplets produced by the coughs from humans naturally-infected with influenza. The novelty of the current collaborative research projectthe Western Cold and Flu (WeCoF) aerosol studylies in the fact that the fluid dynamics of the jet aerosols produced by a minimally-confined cough is being examined concurrently with the biological processes associated with virus droplet formation and transmission, using human subjects when they are naturally infected by influenza virus and, again, when they return to health. A novel experimental facilitythe FLUGIEhas been designed to study the far-field aerodynamics of human coughs produced by subjects naturally-infected with respiratory viruses, together with measurement of the viral content of the droplets produced by those coughs, in order to quantify the factors relating to person-toperson airborne transmission of virus. doi = 10.1186/1756-0500-7-563 id = cord-262442-kjgpriow author = Scalia, Santo title = Quercetin solid lipid microparticles: A flavonoid for inhalation lung delivery date = 2013-05-13 keywords = Calu-3; cell; drug; quercetin; slm; study summary = The quercetin SLMs were characterised for morphology, drug loading (15.5% ± 0.6, which corresponded to an encapsulation efficiency of 71.4%), particle size distribution, response to humidity, crystallinity, thermal behaviour and in vitro respirable fraction. Furthermore, the toxicity and the in vitro transport of the SLMs on an air liquid interface model of the Calu-3 cell line were also investigated using a modified twin-stage impinger apparatus. RESULTS: Results showed that quercetin SLMs could be formulated as dry powder suitable for inhalation drug delivery (20.5 ± 3.3% fine particle fraction ⩽4.46 μm) that was absorbed, via a linear kinetic model across the Calu-3 monolayer (22.32 ± 1.51% over 4 h). A modified in vitro aerosol testing apparatus (twin stage impinger TSI, Radleys, Essex, UK) that allows the attachment of a Transwell containing Calu-3 epithelial cells was used to study the mechanis m of drug deposition, dissolution and diffusion/transp ort (Haghi et al., 2010 (Haghi et al., , 2012 . doi = 10.1016/j.ejps.2013.03.009 id = cord-271573-qsr3ka5p author = Schafer, Austin title = Telemedicine in Pediatric Otolaryngology: Ready for Prime Time? date = 2020-09-24 keywords = ENT; study; telemedicine summary = In a 2008 study, Smith and colleagues 5 attempted to determine concordance between pediatric otolaryngology diagnoses and surgical management plans made via a live videoconference and a subsequent, in-office consultation. 11, 12, 14 More recently, Gupta and colleagues 7 published a study in 2020 that examined the feasibility of equipping trained health workers with a store and forward telemedicine device to triage underserved otology patients in India. While much of the literature focuses on store and forward telemedicine in the context of providing care to remote or underserved populations, its benefits should be considered by all ENT practices during the COVID-19 era, as advances in technology have improved its cost effectiveness and convenience. Both of these studies indicate that smartphone otoscopy can be performed by parents; however, the diagnostic reliability of the captured media must improve for this technology to be widely implemented. doi = 10.1016/j.ijporl.2020.110399 id = cord-340128-qxkopvot author = Schreibauer, Elena Christina title = Work-Related Psychosocial Stress in Small and Medium-Sized Enterprises: An Integrative Review date = 2020-10-13 keywords = Health; Safety; Small; Stress; study; work summary = Conclusions: This review underlines the need for more and better quality research of psychosocial factors in SMEs, particularly in relation to ongoing and new challenges in the workplace, including stressors related to the process of digitalization or the development of safe working conditions during the emerge of new infectious diseases. The reviews did, however, not specifically focus on the situation of employers and employees working in SMEs. Furthermore, the Joint German Occupational Safety and Health Strategy (GDA) published recommendations for implementing psychosocial risk assessments listing five work patterns (i.e., work characteristics) that have been identified as primary stress factors in the workplace [39] : To the best of our knowledge, this review is the first to summarize and categorize the current evidence on work-related psychosocial demands with a specific focus on small and medium sized enterprises to identify gaps in current knowledge and provide a systematic overview of which psychosocial factors, outcomes and economic sectors have been considered to date. doi = 10.3390/ijerph17207446 id = cord-269373-d5xam4kb author = Schumacher, J. title = The impact of respiratory protective equipment on difficult airway management: a randomised, crossover, simulation study date = 2020-05-28 keywords = respirator; study summary = title: The impact of respiratory protective equipment on difficult airway management: a randomised, crossover, simulation study Airway management in critically ill patients contaminated with chemical, biological radiological or nuclear substances requires personal protective equipment (PPE) [1, 2] . This is the first study comparing the impact of modern powered respirators and standard respirators on simulated difficult airway procedures. The primary outcome measure of this study was as the difference in intubation times for various airway management procedures, with wearer comfort a secondary outcome. Airway management times of the Airtraq group, the videolaryngoscopy and the fibreoptic intubation Anaesthetists rated their personal sensation of heat buildup and perceived vision significantly higher in the powered respirator group; however, noise levels scored significantly lower compared to the standard respirator group (Table 2 ). A randomised crossover simulation study comparing the impact of chemical, biological, radiological or nuclear substance personal protection equipment on the performance of advanced life support interventions doi = 10.1111/anae.15102 id = cord-344902-bittqpyo author = Scott, Jennifer title = A systematic review of the physical activity levels of acutely ill older adults in Hospital At Home settings: an under-researched field date = 2020-10-15 keywords = activity; physical; review; study summary = title: A systematic review of the physical activity levels of acutely ill older adults in Hospital At Home settings: an under-researched field PURPOSE: The purpose of this review was to identify, evaluate and synthesise existing evidence reporting the physical activity levels of acutely ill older patients in a ''Hospital At Home'' setting and compare this to patients with similar characteristics treated in a traditional hospital inpatient setting. CONCLUSION: There is a lack of published research on the physical activity levels of acutely-ill older adults in Hospital at Home settings. The aim of this review was to identify, evaluate and synthesise the evidence on the physical activity levels of acutely ill older patients undergoing treatment in an HaH vs inpatient setting. This review has provided an indication of the baseline activity levels of inpatients suitable for a Hospital at Home service, however primary objective research is needed in this treatment setting. doi = 10.1007/s41999-020-00414-y id = cord-338741-gy3ovkrt author = Sethi, Atin title = Evaluation of Current Therapies for COVID-19 Treatment date = 2020-07-22 keywords = COVID-19; SARS; patient; study summary = No survival benefit for those not requiring respiratory support [22] Convalescent plasma n = 10 severely ill patients Treatment: 200 mL IV In all 10 patients, fever, cough, shortness of breath, and chest pain disappeared or largely improved within 1-3 days of therapy initiation [23] In vitro study determining the activity of convalescent plasma from a recovered SARS-1 patient against SARS-CoV-2 Although the focus of this study was not to explore the efficacy of hydroxychloroquine/azithromycin, it outlines the importance of appropriate risk-benefit analysis while treating patients with COVID-19. This randomized control trial [10] of 199 patients explored the efficacy of lopinavir-ritonavir in hospitalized COVID-19 patients with relatively mild respiratory illness. Efficacy of hydroxychloroquine in patients with COVID-19: Results of a randomized clinical trial Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study doi = 10.3390/microorganisms8081097 id = cord-103522-94zqk6lu author = Shah, S. G. S. title = Are digital technology interventions effective to reduce loneliness in older adults? A systematic review and meta-analysis date = 2020-09-01 keywords = September; abstract; loneliness; study summary = For data collection, we used a priori data extraction template (Tables 1-2) , which comprised a number of columns: Author(s), year and country of study; study aim/objectives; research design; settings; participants'' characteristics (age, gender and ethnicity); health/medical condition; sampling method and size; participant attrition (numbers / %), research method(s) / data collection tool(s); intervention(s) (e.g. type/tool of digital technology), comparator(s).(e.g. alternative intervention, placebo or care as usual), intervention duration (weeks / months),.measurement stages (e.g. baseline and follow-up -weeks/months after the baseline), outcomes/results/findings (e.g. loneliness scores (including statistics e.g. mean values, standard deviations, standard errors and confidence intervals) and authors'' conclusion(s) (34) . The effectiveness of social robots for older adults: A systematic review and meta-analysis of randomized controlled studies Effectiveness of digital technology interventions to reduce loneliness in adults: a protocol for a systematic review and meta-analysis The effectiveness of digital technology interventions to reduce loneliness in adult people: a systematic review and meta-analysis doi = 10.1101/2020.08.27.20183012 id = cord-338332-msjtncek author = Sharifian, Neika title = Social Relationships and Adaptation in Later Life date = 2020-09-18 keywords = adult; health; old; relation; social; study summary = While the convoy model provides a heuristic framework within which to understand the causes and consequences of social relations over the life course, SST focuses on the individual''s time perspective and what motivates social interactions while the SAVI model specifies a common strategy among older adults used to maintain high levels of well-being through emotion regulation and avoidance of conflict. An examination of the influence of early parental relationship quality on cognitive health outcomes by Sharifian and colleagues revealed that respondents from a nationally representative U.S. sample of older adults who reported higher retrospective maternal relationship quality showed less decline in episodic memory over time through reduced loneliness and depressive symptoms. Indeed, prior cross-sectional research in a nationally representative sample of American older adults has shown that the use of social technologies in later life was associated with better psychological and physical health outcomes, and these associations were mediated by lower levels of loneliness (Chopik, 2016) . doi = 10.1016/b978-0-12-818697-8.00016-9 id = cord-307202-iz1bo218 author = Shaw, Dominick title = Asthma date = 2014-05-02 keywords = FEV; GWAS; ICS; SNP; airway; asthma; gene; receptor; response; study summary = Current asthma management involves a step-up and step-down approach based on asthma control with a large degree of heterogeneity in responses to the main drug classes currently in use: β(2)-adrenergic receptor agonists, corticosteroids, and leukotriene modifiers. Human studies have identified elevated numbers of cells expressing IL13 mRNA in the bronchial tissue of atopic and nonatopic asthmatic subjects [50] ; administration of recombinant IL13 in mouse lungs resulted in an increase in airway mucus secretion, development of subepithelial fibrosis, airway hyper-responsiveness (AHR), and eosinophilic airway inflammation-that is, several key features of the human disease [51] . While methods of stratifying asthma patients to specific treatments based on nongenetic factors such as clinical outcomes, cellular measures, or protein biomarkers have shown some success, a large body of work has investigated the potential of genetic markers as predictors of patient responses to existing therapies, i.e., pharmacogenetics. doi = 10.1016/b978-0-12-386882-4.00028-1 id = cord-276327-wyevh4xv author = Sheng, Calvin C title = Canakinumab to reduce deterioration of cardiac and respiratory function in SARS‐CoV‐2 associated myocardial injury with heightened inflammation (canakinumab in Covid‐19 cardiac injury: The three C study) date = 2020-08-24 keywords = COVID-19; SARS; patient; study summary = We designed a proof‐of‐concept randomized controlled trial to evaluate whether treatment with canakinumab prevents progressive respiratory failure and worsening cardiac dysfunction in patients with SARS‐CoV2 infection, myocardial injury, and high levels of inflammation. The three C Study is a prospective, IRB approved, blinded randomized-controlled Phase II study designed to evaluate whether treatment with canakinumab prevents progressive heart and respiratory failure in patients with Covid-19 associated myocardial injury and increased inflammation. This blinded randomized controlled trial is designed as a proof of concept study to demonstrate whether IL-1β antagonism can dampen the deleterious autoinflammatory response to SARS-CoV2 infection in patients with myocardial injury and heightened inflammation. In evaluating this hypothesis, the Three C study will help inform whether targeting inappropriate activation of the innate immune system should be investigated in larger clinical trials to improve survival in patients with Covid-19 and myocardial injury. doi = 10.1002/clc.23451 id = cord-286527-e795m6tk author = Sheskin, Mark title = Online Developmental Science to Foster Innovation, Access, and Impact date = 2020-07-02 keywords = cradle; study summary = We propose that developmental cognitive science should invest in an online CRADLE, a Collaboration for Reproducible and Distributed Large-Scale Experiments that crowdsources data from families participating on the internet. We propose that developmental cognitive science should invest in an online CRADLE, a Collaboration for Reproducible and Distributed Large-Scale Experiments that crowdsources data from families participating on the internet. However, our suggestion for an online CRADLE goes beyond the sum of these projects: we envision a shared infrastructure for recruitment, experiment implementation, data collection, and data sharing; families find and participate in studies across developmental science, and researchers coordinate as members of a ''superlab,'' in some ways similar to the Psychological Science Accelerator [10] . Large data sets will be crucial to support neighboring disciplines that build on insights from developmental science, including early childhood education, the study of developmental disorders and interventions, and computational models of typical cognitive development, including artificial intelligence (AI) research, which is increasingly interested in reverseengineering the ways in which infants and young children learn and think to build more human-like machine intelligence that can live better in our human world. doi = 10.1016/j.tics.2020.06.004 id = cord-307038-c58mzcu9 author = Shukla, Nagesh title = A Review of Models Used for Investigating Barriers to Healthcare Access in Australia date = 2020-06-08 keywords = Australia; barrier; health; study summary = This review study is an attempt to understand the various modeling approaches used by researchers to analyze diverse barriers related to specific disease types and the various areal distributions in the country. The study introduced a multilevel approach to assess area-level variation in colorectal cancer survival due to causative factors (disease stage, comorbidity, patient characteristics and healthcare access) and analyze their individual contribution to survival. Most of the studies used the line-of-sight method to measure distances to dental care instead of determining travel time as they focused on metropolitan regions with a focus on using geospatial tools to identify accessibility [13, 16] . Current research practice is lacking in various domains ranging from spatial accessibility techniques to the consideration of patient characteristics and the analysis of different disease types as well as studies concerning only rural/remote areas. doi = 10.3390/ijerph17114087 id = cord-341745-2txzi7kb author = Singh, S. title = Efficacy and Safety of Hydroxychloroquine and Chloroquine for COVID-19: A systematic review date = 2020-05-26 keywords = COVID-19; Hydroxychloroquine; study summary = RESULTS: After a review of 175 citations, we included 5 clinical trials (total of 345 patients), 9 observational studies (n = 2529), and 6 additional studies (n = 775) reporting on the QT interval. CONCLUSIONS: Our systematic review of reported clinical studies did not identify substantial evidence to support the efficacy of hydroxychloroquine or chloroquine in hospitalized COVID-19 patients and raises questions about potential harm from QT prolongation and increased mortality. Our systematic review of reported clinical studies did not identify substantial evidence to support the efficacy of hydroxychloroquine or chloroquine in hospitalized COVID -19 patients and raises questions about potential harm from QT prolongation and increased mortality. We included both published and unpublished clinical trials and observational studies that reported on chloroquine and hydroxychloroquine use either as a single drug or in combination with azithromycin to treat patients hospitalized patients with COVID-19. doi = 10.1101/2020.05.19.20106906 id = cord-300320-07tdrd4w author = Siordia, Juan A. title = Systematic and Statistical Review of Coronavirus Disease 19 Treatment Trials date = 2020-07-15 keywords = SARS; covid-19; study summary = Medications assessed included lopinavir/ritonavir, arbidol, hydroxychloroquine, tocilizumab, favipiravir, heparin, and dexamethasone. Review of literature showed no significant clinical improvement with lopinavir/ritonavir, arbidol, hydroxychloroquine, or remdesivir. Medical therapies investigated included lopinavir/ritonavir, arbidol, hydroxychloroquine, remdesivir, favipiravir, heparin, glucocorticoids, interferon, ivermectin, and convalescent plasma. Key words included COVID-19, SARS-CoV2, randomized, This article is part of the Topical Collection on Covid-19 controlled, human, retrospective, prospective, trial, chloroquine, hydroxychloroquine, lopinavir, ritonavir, arbidol, umifenovir, tocilizumab, favipiravir, steroids, dexamethasone, glucocorticoids, interferon, ivermectin, remdesivir, azithromycin, heparin, and low-molecular weight heparin. Lopinavir/ritonavir, arbidol, hydroxychloroquine, favipiravir, remdesivir, and heparin are medications that have been tested in human controlled trials for COVID-19 treatment. In human trials, arbidol shows no significant positive-negative conversion rate or recovery time compared to standard therapy or lopinavir/ritonavir [4, 9] . Combining T, treatment group (remdesivir); C, control group all the hydroxychloroquine human trials showed no benefit with reducing COVID-19 viral shedding time. doi = 10.1007/s42399-020-00399-6 id = cord-331487-jh34klbg author = Sivapalan, Pradeesh title = Proactive Prophylaxis With Azithromycin and HydroxyChloroquine in Hospitalised Patients With COVID-19 (ProPAC-COVID): A structured summary of a study protocol for a randomised controlled trial date = 2020-06-10 keywords = Azithromycin; COVID-19; patient; study; treatment; trial summary = OBJECTIVES: The aim of this randomised GCP-controlled trial is to clarify whether combination therapy with the antibiotic azithromycin and hydroxychloroquine via anti-inflammation/immune modulation, antiviral efficacy and pre-emptive treatment of supra-infections can shorten hospitalisation duration for patients with COVID-19 (measured as "days alive and out of hospital" as the primary outcome), reduce the risk of noninvasive ventilation, treatment in the intensive care unit and death. Fertile women* must not be pregnant, i.e. negative pregnancy test must be available at inclusion • Informed consent signed by the patient *Defined as after menarche and until postmenopausal (no menstruation for 12 months) Exclusion criteria: • At the time of recruitment, the patient uses >5 LO2/min (equivalent to 40% FiO2 if measured) • Known intolerance/allergy to azithromycin or hydroxychloroquine or hypersensitivity to quinine or 4-aminoquinoline derivatives • Neurogenic hearing loss • Psoriasis • Retinopathy • Maculopathy • Visual field changes • Breastfeeding • Severe liver diseases other than amoebiasis (INR> 1.5 spontaneously) • Severe gastrointestinal, neurological and hematological disorders (investigator-assessed) • eGFR <45 ml/min/1.73 m2 • Clinically significant cardiac conduction disorders/arrhythmias or prolonged QTc interval (QTc (f) of> 480/470 ms). doi = 10.1186/s13063-020-04409-9 id = cord-355318-qm79gz8w author = Smit, Albertus J. title = Winter Is Coming: A Southern Hemisphere Perspective of the Environmental Drivers of SARS-CoV-2 and the Potential Seasonality of COVID-19 date = 2020-08-05 keywords = HIV; SARS; covid-19; environmental; section; study; temperature summary = Knowledge of other viral respiratory diseases suggests that the transmission of SARS-CoV-2 could be modulated by seasonally varying environmental factors such as temperature and humidity. Thus, if climate factors do play a role in COVID-19 infection rates, the concurrence of transition of southern hemisphere countries to their winter season with the mid-stages of the disease transmission trajectory is of concern, especially with respect to containment policy and health system resource allocation. Environmental variables considered in preprint and peer-reviewed publications as modulators of SARS-CoV-2 transmission rates include mean, minimum and/or maximum daily temperature, and diurnal temperature range; an undefined ''humidity'' variable, relative humidity, specific humidity and absolute humidity; dew point temperature; rainfall; wind speed or wind power; air pressure; some metric of solar or UV radiation; and ''air quality'' (Supplementary Tables S1 and S2 ). The general prevalence of climatologically-coupled seasonal signals and environmental variable modulation seen in the majority of other viral respiratory diseases creates the expectation for a similar effect on SARS-CoV-2 and in COVID-19 epidemiology. doi = 10.3390/ijerph17165634 id = cord-029112-u507i0t0 author = Smith, Keisha title = A Phase 3 Open-label, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Intravenously Administered Ravulizumab Compared with Best Supportive Care in Patients with COVID-19 Severe Pneumonia, Acute Lung Injury, or Acute Respiratory Distress Syndrome: A structured summary of a study protocol for a randomised controlled trial date = 2020-07-13 keywords = ALXN1210-COV-305; Alexion; Amendment; BSC; Investigator; SAE; day; patient; study summary = Study ALXN1210-COV-305 is a multicenter Phase 3, open-label, randomized, controlled study designed to evaluate the safety and efficacy of intravenous (IV) ravulizumab + best supportive care (BSC), compared with BSC alone in patients with a confirmed diagnosis of SARS-CoV-2 infection, and a clinical presentation consistent with COVID-19 severe pneumonia, acute lung injury, or ARDS. doi = 10.1186/s13063-020-04548-z id = cord-015935-r2wd1yfa author = Sokol, Deborah K. title = The Genetics of Autism date = 2011-02-10 keywords = FXS; autism; dna; gene; study summary = Another offshoot of microarray technology is submicroscopic chromosome copy number variation (CNV) analysis, in which deletions or duplications involving > 1-kb DNA have been detected in patients with mental retardation, autism, and multiple congenital anomalies. Technology compatible with this approach includes cytogenetics (including karyotyping and FISH), gene association studies (analysis of genes and protein system from less complex genetic syndromes similar to autism such as Rett and fragile X syndromes), linkage studies (including genome screens in affected sibling pairs), microarray technology, and CNV analysis. Cytogenetic approaches provided the first evidence for an autism gene 40 years ago when Lubs (1969) identified an abnormal or "fragile" site on the long arm of chromosome X in four males with mental retardation, leading to the recognition of fragile X syndrome (FXS). As chromosome 7q has been discussed in section "Cytogenetics: Rare Mutations," chromosome 2 and then 17q11 will follow the description of how linkage studies led to the discovery of the gene loci for a syndromic form of autism: tuberous sclerosis complex (TSC). doi = 10.1007/978-1-4419-8065-6_6 id = cord-338889-7hd3iibk author = Solbakk, Jan Helge title = Back to WHAT? The role of research ethics in pandemic times date = 2020-11-03 keywords = Declaration; Human; SARS; Selgelid; covid-19; research; risk; study summary = 10 Of the 10 standards laid down in this Code, and with which physician-researchers must comply when carrying out experiments on human subjects, standard 5, in particular, has become highly relevant these days due to pressure from influential medical stakeholders, agencies and bioethicists to permit the conduct of controlled human infection studies (CHIs), also labeled human challenge trials (HCTs), or challenge studies (CSs) to possibly shorten the development time of vaccines to protect against Covid-19 caused by the SARS-CoV-2 virus. doi = 10.1007/s11019-020-09984-x id = cord-014464-m5n250r2 author = Sole-Violan, J title = Lethal influenza virus A H1N1 infection in two relatives with autosomal dominant GATA-2 deficiency date = 2013-03-19 keywords = AKI; APACHE; ARDS; Care; ICU; IL-6; Introduction; RBC; TBI; day; figure; group; hour; method; mortality; outcome; patient; peep; result; signifi; sofa; study summary = Results In preliminary analysis of categorical data, a signifi cantly (Fisher exact test) greater proportion of patients with compared with without the following fi ndings did not survive; history of alcohol use (P = 0.05); the presence of lethargy (P = 0.01), confusion (P = 0.03), nausea (P = 0.04), abdominal pain (P = 0.02), or the need for vasopressors (P = 0.002), oxygen, mechanical ventilation, or steroids (all P = 0.004) at presentation; and excessive bleeding at surgery (P = 0.01). Methods To prospectively re-evaluate the normal range and to analyze the potential impact of biometric data on ICG-PDR, we measured ICG-PDR (i.v. injection of 0.25 mg/kg ICG; LiMON, Pulsion, Munich, Introduction Mixed venous oxygen saturation (SVO 2 ) represents a well-recognized parameter of oxygen delivery (DO 2 )-consumption (VO 2 ) mismatch and its use has been advocated in critically ill patients in order to guide hemodynamic resuscitation [1] and oxygen delivery optimization. doi = 10.1186/cc11953 id = cord-286889-l765mxmy author = Stangeland, Paula A. title = Disaster Nursing: A Retrospective Review date = 2010-12-31 keywords = Katrina; PTSD; disaster; nurse; study summary = Eight themes, including (1) defining disaster, (2) nursing during and after disaster, (3) nursing education in disaster preparedness, (4) military nurse preparedness, (5) postdisaster stress, (6) ethical issues and intent to respond, (7) policy, and (8) hospital emergency policy, were derived from the review and are explored in this article. Although some nurses identified their experiences of working during and in the aftermath of Hurricane Katrina and other health emergencies as rewarding, they also identified planning and education as critical needs for providing care in future disasters. 20 Specifically, the guidelines state that baccalaureate nursing programs should prepare graduates to use clinical judgment appropriately and provide timely interventions when making decisions and performing nursing care during disasters, mass casualties, and other emergency situations. Because the literature reveals that working during disasters and traumatic situations causes increased stress for nurses, it is necessary to include information related to disorders that have been associated with experiencing traumatic situations. doi = 10.1016/j.ccell.2010.09.003 id = cord-330573-rr2r8245 author = Stockmann, Helena title = CytoResc – “CytoSorb” Rescue for critically ill patients undergoing the COVID-19 Cytokine Storm: A structured summary of a study protocol for a randomized controlled trial date = 2020-06-26 keywords = patient; study summary = title: CytoResc – "CytoSorb" Rescue for critically ill patients undergoing the COVID-19 Cytokine Storm: A structured summary of a study protocol for a randomized controlled trial TRIAL DESIGN: Phase IIb, multicenter, prospective, open-label, randomized, 1:1 parallel group pilot study comparing the additional use of "CytoSorb" to standard of care without "CytoSorb". Intervention and comparator: Within 24 hours after meeting the inclusion criteria patients will be randomized to receive either standard of care or standard of care and additional "CytoSorb" therapy via a shaldon catheter for 3-7 days. Keywords: COVID-19, Randomized controlled trial, protocol, cytokine storm, vasoplegic shock, extracorporeal cytokine elimination Authors'' contributions TS, PE and HS designed the trial, wrote the study protocol, obtained ethical approval and applied for BMBF funding. TK did the biostatistic design of the trial and wrote the statistical section of the study protocol, ethical approval and BMBF application. Furthermore, the study protocol, the statistical analysis plan, the patient information and the patient consent form will be made available to all interested persons. doi = 10.1186/s13063-020-04501-0 id = cord-011325-r42hzazp author = Stowe, Julia title = Do Vaccines Trigger Neurological Diseases? Epidemiological Evaluation of Vaccination and Neurological Diseases Using Examples of Multiple Sclerosis, Guillain–Barré Syndrome and Narcolepsy date = 2019-10-01 keywords = risk; study; vaccine summary = doi = 10.1007/s40263-019-00670-y id = cord-170195-lrg11s5n author = Stoye, Jorg title = A Critical Assessment of Some Recent Work on COVID-19 date = 2020-05-20 keywords = Gangelt; study; test summary = I tentatively re-analyze data from two well-publicized studies on COVID-19, namely the Charit''{e}"viral load in children"and the Bonn"seroprevalence in Heinsberg/Gangelt"study, from information available in the preprints. The authors focus on a hypothesis test as deliverable of their analysis; I would have recommended a nonparametric mean regression with error bands, resulting in some estimated age effect. To the statistically educated reader, the above headlines may suggest that the study tests, and fails to reject, H 0 : "Children have the same viral load as adults." It does not. To take an educated guess, I will now try to recover from the paper a test of H 0 : "Children have the same viral load as adults." To this purpose, I combine the first two and the remaining age bins of Figure 1 to find means of 4.74 and 5.21 with 95% confidence intervals of [4.42, 5.05] and [5.15, 5.27], respectively. doi = nan id = cord-319504-jb455t9p author = Suess, Thorsten title = The role of facemasks and hand hygiene in the prevention of influenza transmission in households: results from a cluster randomised trial; Berlin, Germany, 2009-2011 date = 2012-01-26 keywords = household; intervention; study summary = BACKGROUND: Previous controlled studies on the effect of non-pharmaceutical interventions (NPI) namely the use of facemasks and intensified hand hygiene in preventing household transmission of influenza have not produced definitive results. When analysing only households where intervention was implemented within 36 h after symptom onset of the index case, secondary infection in the pooled M and MH groups was significantly lower compared to the control group (adjusted odds ratio 0.16, 95% CI, 0.03-0.92). Since 2006, the World Health Organisation (WHO) and other organisations have highlighted the need for controlled trials to assist in formulating recommendations on the use of non-pharmaceutical interventions (NPI)such as facemasks or hand hygiene measures -as options to prevent influenza transmission, particularly in households [1, 2] . In intention-to-treat analysis, none of the four household based trials was able to show significant reductions in secondary attack rates (SAR) when comparing intervention to control groups. doi = 10.1186/1471-2334-12-26 id = cord-354216-4khdcjed author = Sultan, Shahnaz title = AGA Institute Rapid Review of the GI and Liver Manifestations of COVID-19, Meta-Analysis of International Data, and Recommendations for the Consultative Management of Patients with COVID-19 date = 2020-05-11 keywords = COVID-19; Clinical; patient; study summary = Abstract Background Multiple gastrointestinal (GI) symptoms including diarrhea, nausea/vomiting, and abdominal pain, as well liver enzyme abnormalities have been variably reported in patients with COVID-19. The AGA) Institute Clinical Guideline Committee and Clinical Practice Updates Committee performed a systematic review and meta-analysis of international data on GI and liver manifestations of COVID-19. 4 More recent data from a cohort of 5700 hospitalized patients with COVID-19 within a large healthcare system in New York City revealed common comorbidities including hypertension (56.6%), obesity (41.7%), and diabetes (33.8%), and reported that 373 (14.2%) of patients required treatment in the intensive care unit, and 320 (12.2%) received invasive mechanical ventilation, in whom the mortality was 88.1% (282/320)]. Also, many of the studies in this analysis did not report on how many patients had underlying liver disease and if these patients were at an elevated risk of having increased LFTs in the setting of COVID-19 infection. doi = 10.1053/j.gastro.2020.05.001 id = cord-275340-q8d7rvnj author = Sun, JingKang title = Advances in the use of chloroquine and hydroxychloroquine for the treatment of COVID-19 date = 2020-06-21 keywords = COVID-19; HCQ; SARS; patient; study summary = CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells. ACE2, angiotensin-converting enzyme 2; COVID-19, coronavirus disease 2019; CQ, chloroquine; HCQ, hydroxychloroquine; CoVs, coronaviruses; MAPK, mitogen-activated protein kinase; MHC-II, major histocompatibility complex class II; TLR, toll-like receptor; cGAS, cyclic GMP-AMP synthase; IFN, interferon; IL, interleukin; TNF-α, tumor necrosis factor-α. The authors deemed that the anti-inflammatory effect of low-dose HCQ and the activity of inhibiting viral replication may have important significance in critically ill patients with COVID-19. doi = 10.1080/00325481.2020.1778982 id = cord-307263-znuqdzdp author = Sun, Niuniu title = A Qualitative Study on the Psychological Experience of Caregivers of COVID-19 Patients date = 2020-04-08 keywords = SARS; nurse; psychological; study summary = Previous studies have shown that during sudden natural disasters and infectious diseases, nurses will sacrifice their own needs to actively participate in the anti-epidemic work and make selfless contributions out of moral and professional responsibility [7] . Previous studies have shown that when nurses are in close contact with patients with emerging infectious diseases such as SARS [9] , MERS-Cov [10, 11] , Ebola [12] , H1N1 [13] , they will suffer from loneliness, anxiety, fear, fatigue, sleep disorders, and other physical and mental health problems. This study explored the psychological experience of caregivers of patients with COVID-19 using phenomenological methods and we summarised our findings into four themes: significant amounts of negative emotions at an early stage, self-coping styles, growth under stress, and positive emotions that occur simultaneously or progressively with negative emotions. doi = 10.1016/j.ajic.2020.03.018 id = cord-014540-27hnlu5v author = Sutthiruk, Nantanit title = Abstracts from the 8th International Congress of the Asia Pacific Society of Infection Control (APSIC): Bangkok, Thailand. 12-15 February 2017 date = 2017-02-22 keywords = CPE; Chen; Control; Infection; Lee; MRSA; Resistance; SSI; VAP; hygiene; patient; study summary = A secondary questionnaire was sent to determine whether any cases showed a positive blood or cerebral spinal fluid culture for Extended Spectrum Beta-lactamase (ESBL) producing GNB, AmpC β-lactamases producing GNB, or carbapenem-resistant enterobacteriacae (CRE) between April 2012 and March 2015.The following data were collected; demographic data pertaining to both the care facilities and patients, clinical diagnosis, and outcomes. Utilization of diagnosis-procedure combination data for advancing the antimicrobial stewardship program Haruo Nakayama, Toshiko Ota, Naoko Shirane, Chikako Matuoka, Kentaro Kodama, Masanobu Ohtsuka Toho University Ohashi medical center, Tokyo, Japan Background Infection with antibiotic-resistant bacteria results in increased morbidity, mortality and economic burden. The purpose of this study was to test the effectively of the Infection Control Risk Assessment (ICRA) monitoring tool developed by the Infection Prevention and Control Unit (IPCU) of Asian Hospital and Medical Center with the aim to increase the compliance of construction workers to recommended infection prevention and control measures during construction, renovation and demolition in the hospital. doi = 10.1186/s13756-017-0176-1 id = cord-292978-qfw1uqvp author = Thakrar, Amit title = Thirty-Day Mortality Rate of Patients With Hip Fractures During the COVID-19 Pandemic: A Single Centre Prospective Study in the United Kingdom date = 2020-07-08 keywords = Study; covid-19 summary = title: Thirty-Day Mortality Rate of Patients With Hip Fractures During the COVID-19 Pandemic: A Single Centre Prospective Study in the United Kingdom We collected data on time to surgery, Clinical Frailty Scale score, Nottingham Hip Fracture Score, COVID-19 infection status, 30-day mortality, and cause of death. CONCLUSIONS: Our study demonstrated a significant increase in 30-day mortality among hip fracture patients during the first 30 days of the COVID-19 pandemic in the United Kingdom. The objective of our study is to investigate and describe associated risk factors for 30-day mortality of patients with hip fractures in a single center for a 1-month follow-up period since "day 0" of the COVID-19 pandemic in the United Kingdom. We collected data on patient demographics, Clinical Frailty Scale (CFS), Nottingham Hip Fracture Score (NHFS), time to surgery, operation type, COVID-19 testing, COVID-19 infection status, 30-day mortality, and cause of death. doi = 10.1097/bot.0000000000001889 id = cord-025304-qfpfllay author = Tiddi, Ilaria title = Fostering Scientific Meta-analyses with Knowledge Graphs: A Case-Study date = 2020-05-07 keywords = analysis; meta; research; study summary = 3,000 studies collecting 60 years of research publications with experimental settings, measured/manipulated variables of observation, and quantitative results, with the goal of establishing an open access database that researchers worldwide could consult to identify studies to include in their systematic literature reviews, as well as to directly conduct their own statistical (meta-)analyses. Conducting a meta-analysis then consists in: (1) Coding, i.e. annotating the studies with the relevant characteristics, including independent and dependent variables and effect sizes; (2) Analysis, i.e. estimating the overall effects using fixed and random effects models, determining heterogeneity in the studies, assessing publication bias, conducting moderator analyses through meta regression, performing statistical power analysis; (3) Interpretation, i.e. the presentation of the obtained results along with conclusions and graphical support, often including graphs such as forests, funnel, violin/scatter-box plots. doi = 10.1007/978-3-030-49461-2_17 id = cord-325201-yoy7kdli author = Timsit, Jean-François title = Year in review in Intensive Care Medicine 2014: III. Severe infections, septic shock, healthcare-associated infections, highly resistant bacteria, invasive fungal infections, severe viral infections, Ebola virus disease and paediatrics date = 2015-03-26 keywords = BSI; Candida; ICU; PICU; patient; study summary = This third article for the 2014 Year in Review will report publications from intensive care on severe infections (including endocarditis and peritonitis), septic shock, healthcare and ventilator associated pneumonia, highly resistant bacteria, antimicrobial therapy (including antibiotic stewardship, therapeutic drug monitoring and deescalation), invasive fungal infections, severe viral infections, Ebola virus disease and paediatrics. While it is now well recognized that early appropriate antimicrobial therapy reduces infection-related morbidity and mortality in the critically ill patients, the importance of pharmacodynamic (PD) dosing to optimize drug exposure continues to evolve. Bacteremia is one of the major causes of nosocomial infection in the intensive care unit (ICU), ICU-acquired bloodstream infection (ICU-BSI) is associated with increased morbidity and length of stay, resulting in excess costs and high mortality of critically ill patients. In addition, in a small randomized study on the efficacy of empiric treatment of suspected ventilator associated pneumonia in patients with candida colonization of the respiratory tract did not prove to be effective [40] . doi = 10.1007/s00134-015-3755-8 id = cord-293522-gg706q8s author = Toumi, Mondher title = Commentary on “Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open label non-randomized clinical trial” by Gautret et al date = 2020-05-13 keywords = COVID-19; hydroxychloroquine; patient; study summary = title: Commentary on "Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open label non-randomized clinical trial" by Gautret et al The results of a clinical trial comparing hydroxychloroquine with or without azithromycin to the standard of care for the treatment of COVID-19 were recently published by Philippe Gautret et al. This study provides outstanding results for the combination of hydroxychloroquine and azithromycin over the standard of care, but the evidence was deemed insufficiently robust to warrant a public health decision to widen the use of hydroxychloroquine for the treatment of COVID-19. The results of a clinical trial comparing hydroxychloroquine with or without azithromycin to the standard of care for the treatment of COVID-19 were published in the International Journal of Antimicrobial Agents by Philippe Gautret et al. The US Centers for Disease Control and Prevention provides information on the use of hydroxychloroquine and chloroquine in the USA to treat coronavirus 2infected patients. doi = 10.1080/20016689.2020.1758390 id = cord-255877-k8r98w3e author = Toye, Francine title = A qualitative evidence synthesis using meta-ethnography to understand the experience of living with pelvic organ prolapse date = 2020-09-01 keywords = pelvic; pop; study summary = title: A qualitative evidence synthesis using meta-ethnography to understand the experience of living with pelvic organ prolapse Our innovation was to undertake a comprehensive search and conceptual synthesis of primary qualitative research using the methods of meta-ethnography to help us to understand what it like to live with POP. We organized 162 ideas from the primary studies into 27 conceptual categories and 10 themes: my body is broken; the life of a woman can take its toll; I am broken; it has taken the woman out of me; my world is shrinking; pelvic organ prolapse is taboo; what on earth is going on down there; powerless in healthcare; which treatment should I choose; it was a relief to tell someone about it. Exploration of sexual experience among women with pelvic organ prolapse: a qualitative study doi = 10.1007/s00192-020-04494-z id = cord-010812-zs51z5la author = Vaisbourd, Yulia title = The effect of patent ductus arteriosus on coronary artery blood flow in premature infants: a prospective observational pilot study date = 2020-02-20 keywords = PDA; coronary; study summary = doi = 10.1038/s41372-020-0622-4 id = cord-291083-nd7cew7v author = Vargas-Medrano, Javier title = Psychological and Neurobiological Aspects of Suicide in Adolescents: Current Outlooks date = 2020-08-05 keywords = adolescent; behavior; risk; study; suicidal; suicide summary = Several reports from the literature have shown that newborns with low birth weight (<2500g) have significantly increased risk of major depression with suicidal ideation, anxiety disorders, phobias, and impaired functioning compared to those with normal birth weights (Nomura et al., 2007) . Dysregulation of serotonin, HPA axis genes, and immune system in the human brain, especially in the frontal cortex, can affect human behaviors such as impulsivity, decision-making and mood and they have been strongly associated with the risk of suicidal behavior as they all play an important role in the body''s response to stress (Roy et al., 2012) . is also known that cognitive-behavioral sleep interventions might improve mental health in adolescents (particularly anxiety and depression) by improving sleep problems, since sleep is also a major risk factor for suicide. Further, their detailed evaluations indicated that vortioxetine was not associated with an increased risk of suicidal ideation and behavior in adult patients with MDD (Mahableshwarkar et al., 2020) . doi = 10.1016/j.bbih.2020.100124 id = cord-274802-7ioiwsd8 author = Varghese, Praveen Mathews title = Host-pathogen interaction in COVID-19: Pathogenesis, potential therapeutics and vaccination strategies date = 2020-08-19 keywords = COVID-19; China; CoV-2; Coronavirus; SARS; Syndrome; acute; cell; clinical; patient; severe; study summary = Proteomic and transcriptomic studies on bronchoalveolar lavage (BAL) samples from COVID-19 patients have also revealed considerable insights into the expression of SARS-CoV-2 receptors, co-receptors, immune responses, as well as risk factors for severe disease e.g. age and co-morbidities. Furthermore, treatment with a recombinant C5a antibody on 2 male COVID-19 patients aged 54 and 67 years showed significant benefit in suppressing complement hyperactivation, which contributes to the excessive immune response causing aggravated inflammatory lung injury, a hallmark of SARS-CoV-2 pathogenesis and lethality (242) . Consistent with endothelial injury, the significantly elevated levels of von Willebrand factor found in the patient with severe COVID-19 has led to the idea that the infection of the ACE2 expressing endothelium by SARS-CoV-2 induces injury and activates the complement , which sets up a feedback loop that maintains a state of inflammation (243, (268) (269) (270) . Initial clinical studies in China involving 100 SARS-CoV-2 infected patients, who were treated with Chloroquine, showed amelioration of pneumonia, shortened disease progression, increased resolution of lung lesions on CT, and a better virus-negative conversion (313, 314) . doi = 10.1016/j.imbio.2020.152008 id = cord-276896-14zq3tln author = Vaz, Manjulika title = Public perceptions on Controlled Human Infection Model (CHIM) studies—a qualitative pilot study from South India date = 2020-10-21 keywords = CHIM; FGD; India; Urban; research; study summary = The scholarly article by Bambery et al (2016) , suggests four requirements for human challenge studies to be ethical ''(i) conduct independent expert reviews, including systematic reviews; (ii) ensure a publicly available rationale for the research; (iii) implement measures to protect the public from the spread of infection beyond the research setting; and (iv) develop a new system for compensation for harm'' (Bambery et al. The key strata of general public covered were males and females, youth and middle aged, members of the public belonging to specific work categories-college students, Information Technology professionals (Bangalore is the IT hub of the country), un-organized sector workers, and mid-income school teachers in the urban areas and members of women''s self-help groups, farmers collectives, community health workers and youth groups in the rural areas. For Controlled Human Infection studies with its contentious ethical positions, the value of public perceptions in identifying regulatory requirements and researcher responsibilities emerges as critical in the process of ensuring transparency and building trust. doi = 10.1007/s40592-020-00121-1 id = cord-014533-6qfecv5h author = Velasquez, T. title = ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016 date = 2016-09-29 keywords = AKI; ARDS; CPR; Care; Hospital; ICU; Intensive; group; introduction; method; objective; patient; peep; result; study summary = P. Tirapu; Navarro-Guillamón, L.; Cordovilla-Guardia, S.; Iglesias-Santiago, A.; Guerrero-López, F.; Fernández-Mondéjar, E.; Vidal, A.; Perez, M.; Juez, A.; Arias, N.; Colino, L.; Perez, J. Methods: This descriptive observational study was conducted on consecutive 100 pediatric surgical patients who admitted to PSICUs at Cairo University Hospitals starting from 1/6-1/12/2015.After approval by research ethics committee,informed consents were obtained from parents and pediatric cases aged from 1 month-18 years and stayed for > 48 h were enrolled.MPV and PLC were obtained and recorded at baseline(preoperative values),on the day of ICU admission(day 0),1 st ,2 nd ,3 rd ,5 th and 7 th days.To measure daily MPV changes; (ΔMPV) was constructed and computed where ΔMPV = ([MPVday(X) − MPVday (0)]/MPVday(0) × 100 %. Results: The results obtained after analyzing the two homogeneous groups according to age, gender, type of admission and severity influencing the physiotherapy care in ICU quality indicators, in the Sagrada Esperança clinic, highlights the decrease of the average number of days with mechanical ventilation but it is not observed a significant relation between physical therapy and this indicator (p = 0:06). doi = 10.1186/s40635-016-0100-7 id = cord-260605-smkr7b15 author = Vestby, Lene K. title = Bacterial Biofilm and its Role in the Pathogenesis of Disease date = 2020-02-03 keywords = IBC; bacterial; biofilm; chronic; infection; patient; study summary = However, the biofilm lifestyle of microorganisms were of no interest to medical microbiologists until the early 1970s when Nils Høiby observed a link between the etiology of a persistent infection and aggregates of bacteria in cystic fibrosis patients [1] . This is consistent with the experiments showing that many bacteria causing acute gallbladder infections do not form biofilms on gallstones in the presence of bile [73, 80] . This is consistent with the experiments showing that many bacteria causing acute gallbladder infections do not form biofilms on gallstones in the presence of bile [73, 80] . Several studies have detected higher incidence of Escherichia coli in patients with IBD compared to healthy individuals [90] and although biofilms were not demonstrated in vivo, the isolates were isolated from biopsies after removal of the mucosal layer, indicating adherence to the colonic epithelium and the isolates displayed biofilm forming capacity in vitro [90] . doi = 10.3390/antibiotics9020059 id = cord-032926-mrnsaexq author = Waitz, Markus title = Application of two different nasal CPAP levels for the treatment of respiratory distress syndrome in preterm infants—“The OPTTIMMAL-Trial”—Optimizing PEEP To The IMMAture Lungs: study protocol of a randomized controlled trial date = 2020-10-01 keywords = CPAP; peep; study summary = BACKGROUND: Nasal continuous positive airway pressure (CPAP) applies positive end-expiratory pressure (PEEP) and has been shown to reduce the need for intubation and invasive mechanical ventilation in very low birth weight infants with respiratory distress syndrome. Results of a secondary analysis from a cohort study in 34 international centers that participated in a nasal intermittent positive pressure ventilation trial indicate a large variation of PEEP levels used in clinical practice during neonatal resuscitation and the first 28 days of life (i.e., 3-9 cmH 2 O) [10] . The primary hypothesis of this study is that the use of a higher PEEP range in preterm infants born at 26 + 0-29 + 6 weeks gestational age (GA) receiving prophylactic nasal CPAP support after birth reduces the incidence of intubation and/or meeting predefined CPAP failure criteria within the first 120 h of life when compared to the application of a lower PEEP range. doi = 10.1186/s13063-020-04660-0 id = cord-267006-gsevwptc author = Waltz, Jeffrey title = Improving CT-Derived Fractional Flow Reserve Analysis: A Quality Improvement Initiative date = 2020-10-07 keywords = CCTA; FFRCT; study summary = Objectives The aim of this study was to identify factors and quality improvement strategies to improve coronary computed tomography angiography (CCTA) studies referred for fractional flow reserve derived from CT angiography (FFRCT) analysis. To evaluate potential issues, a question and answer session with a brief didactic lecture was given by an expert cardiovascular radiologist to the CT technologists and the nursing staff, including an overview of coronary artery imaging and the purpose of performing CCTA and FFRCT at our institution. To evaluate the effect of pre-scan medication use on overall CCTA image quality at our institution, the radiology nurses were instructed to give every patient nitroglycerine and a beta-blocker, if required and not contraindicated, to achieve a heart rate of <70 and preferably <60. A second random sample of 30 CCTA cases performed during the month of November 2019 was reviewed by the same expert cardiovascular radiologist to assess for early post-intervention changes following the initial medication changes to confirm that improvement could be seen in the visual quality score. doi = 10.7759/cureus.10835 id = cord-327607-g0jtrwot author = Weinberg, Marc Scott title = Clinical Trials and Tribulations in the COVID-19 Era date = 2020-05-19 keywords = Alzheimer; COVID-19; study; subject summary = Here we describe novel approaches and work-flow adaptations to study visits, drug delivery and interim and endpoint safety and outcomes assessments to avoid sacrificing years of preparation and substantial financial investments, to work in the best interest of participants and their caregivers, and to continue on the path towards discovering disease-modifying treatments for the millions of individuals impacted by major neurocognitive disorders. Here we describe novel approaches and work-flow adaptations to study visits, drug delivery and interim and endpoint safety and outcomes assessments to avoid sacrificing years of preparation and substantial financial investments, to work in the best interest of participants and their caregivers, and to continue on the path towards discovering disease-modifying treatments for the millions of individuals impacted by major neurocognitive disorders. While some of the same challenges limiting safety / biomarker visits also apply to in-person clinical and cognitive scale administration, there is already a literature base providing at least provisional support for the validity and reliability of performing assessments via tele-neuropsychology (TeleNP), including in older adults (e.g., [8] [9] [10] [11] [12] . doi = 10.1016/j.jagp.2020.05.016 id = cord-252922-cdhnlvxv author = West, Erin A. title = Corona Immunitas: study protocol of a nationwide program of SARS-CoV-2 seroprevalence and seroepidemiologic studies in Switzerland date = 2020-10-24 keywords = Corona; Immunitas; SARS; Switzerland; study summary = We describe here the protocol of Corona Immunitas, a centrally coordinated research program consisting of repeated cross-sectional and longitudinal seroprevalence and seroepidemiological studies conducted across several regions and populations in Switzerland, whose aim is to generate reliable data to inform policy-making. Specific aims are to: (1) estimate the number of individuals infected with SARS-CoV-2 in the population with or without symptoms at several points in time; (2) compare the seroprevalence between the general population and specific subpopulations; (3) investigate the characteristics, duration, and extent of immunity after infection; (4) assess the association between participant characteristics and behaviors with their risk of infection; and (5) quantify the association between the pandemic and participants'' mental and physical health. Corona Immunitas is a research program coordinated by SSPH?, conducting longitudinal, population-based seroprevalence studies covering a number of Swiss Cantons as well as several seroepidemiological studies in specific subpopulations. doi = 10.1007/s00038-020-01494-0 id = cord-349161-4899cq99 author = Whiting, Penny F title = Graphical presentation of diagnostic information date = 2008-04-11 keywords = ROC; diagnostic; review; study; test summary = For diagnostic accuracy studies, measures of test performance (sensitivity, specificity, predictive values, likelihood ratios or diagnostic odds ratio) are plotted on the horizontal axis. ROC plots can be used to present the results of diagnostic systematic reviews, but differ from those used in primary studies as each point typically represents a separate study or data set within a study (individual studies may contribute more than one point). A summary ROC (SROC) curve can be estimated using one of several methods [12] [13] [14] [15] and quantifies test accuracy and the association between sensitivity and specificity based on differences between studies. A number of graphical displays aim to put results of diagnostic test evaluations into clinical context, based either on primary studies or systematic reviews. The inclusion of graphical displays, such as SROC plots or forest plots, in systematic reviews of test accuracy studies allows a visual assessment of heterogeneity between studies by showing the results from each individual study included in the review. doi = 10.1186/1471-2288-8-20 id = cord-017955-oipail5l author = Wilkie, David A. title = The Ophthalmic Examination as It Pertains to General Ocular Toxicology: Basic and Advanced Techniques and Species-Associated Findings date = 2013-08-29 keywords = Fig; IOP; OCT; animal; corneal; ocular; study summary = However, if the purpose of such a study is to screen for adverse effects on any ocular tissue including, at a minimum, the adnexal structures (eyelids and conjunctiva), anterior segment (cornea, anterior chamber, iris, and lens), and posterior segment (vitreous and fundus), the following must be included: Additional procedures may be included depending on the objective of the examination. Additional examination procedures such as direct ophthalmoscopy, corneal staining, tonometry, pachymetry, fluorescein angiography, photographic documentation (anterior or posterior segment), electrodiagnostic testing, ultrasonography, OCT, and other tests may be indicated depending on the study and toxicologic effects of interest. Examples of ocular findings that may be progressive during the course of the study and Common background abnormalities will vary by species, but may include ocular trauma associated with shipping, congenital embryonic remnants such as persistent pupillary membrane (PPM) and persistent hyaloid artery (PHA), extravasation of blood in association with a PHA, corneal opacity/dystrophy, coloboma (iris, lens, choroid), cataract, micropapilla, optic nerve hypoplasia, and retinal dysplasia [1, 7-9, 11, 16-28] . doi = 10.1007/7653_2013_7 id = cord-290347-q6r6g7ue author = Williams, Lloyd B. title = Impact and Trends in Global Ophthalmology date = 2020-06-22 keywords = Africa; retinopathy; study summary = A key finding of this study was that the AI system was able to identify disease in an African cohort with high sensitivity and specificity even though the system was trained on patients of Asian origin from the Singapore Integrated Diabetic Retinopathy Program. To our knowledge, a prospective study of glaucoma detection via AI has yet to be published from the setting of the developing world, though it is foreseeable that a low-cost implantation of this technology may aid eye care professionals in the early diagnosis and treatment of glaucoma (Fig. 1a) . Global estimates on the number of people blind or visually impaired by diabetic retinopathy: a meta-analysis from Incidence and progression of diabetic retinopathy in sub-Saharan Africa: a five-year cohort study Artificial intelligence using deep learning to screen for referable and vision-threatening diabetic retinopathy in Africa: a clinical validation study doi = 10.1007/s40135-020-00245-x id = cord-326004-wg47sd06 author = Wilson, Patrick T title = Respiratory Pathogens in Children 1 Month to 5 Years of Age Presenting With Undifferentiated Acute Respiratory Distress in 2 District-Level Hospitals in Ghana date = 2018-09-03 keywords = Ghana; respiratory; study summary = A recently conducted prospective randomized controlled trial at 2 district-level hospitals in Ghana revealed that the use of continuous positive airway pressure (CPAP) reduces the allcause mortality rate in children <1 year old who presented with undifferentiated acute respiratory distress [3] . In that study, nasopharyngeal swabs were collected from the children at the time of presentation and tested for common pediatric respiratory pathogens; the goal was to decrease the knowledge gap regarding the incidence of respiratory pathogens that affect children <5 years of age in low-and middle-income countries. In this report, we describe the respiratory pathogens detected in children aged 1 month to 5 years who presented to 1 of 2 district-level hospitals in Ghana with undifferentiated acute respiratory distress. Despite the limitations of this study, our results show that viral respiratory pathogens were frequent among children aged 1 month to 5 years who presented with acute respiratory distress to 1 of 2 district-level hospitals in Ghana. doi = 10.1093/jpids/piy090 id = cord-276711-y74zr7fn author = Winthrop, Kevin L title = To immunosuppress: whom, when and how? That is the question with COVID-19 date = 2020-08-04 keywords = COVID-19; study summary = 1 After a difficult March 2019 of high hospitalisation and death rates with COVID-19, on 1 April their institution started a standard protocol of treating patients with COVID-19 with high-dose methylprednisolone for 5-7 days during which time individuals not showing clinical improvement were also given the interleukin 6 (IL-6) receptor-blocking agent tocilizumab. An early observational report from China that used propensity methods to match steroid-treated COVID-19 cases to noncases suggested non-significant trends towards worse outcomes among those using 40-50 mg of methylprednisolone per day compared with those not using steroids. 19 Contrary to this study, an institutional cohort at the University of Michigan of patients with COVID-19 on mechanical ventilation suggested a strong survivor benefit for those using tocilizumab, as mortality was nearly halved, despite an increase in secondary bacterial infections. Their phase 2/3 adaptive trial first reported that in phase 2, sarilumab was not effective in patients with less severe COVID-19 pneumonia (ie, those not mechanically ventilated 27 ). doi = 10.1136/annrheumdis-2020-218694 id = cord-301393-d1duepnb author = Wolfensberger, Aline title = Implementation and evaluation of a care bundle for prevention of non-ventilator-associated hospital-acquired pneumonia (nvHAP) – a mixed-methods study protocol for a hybrid type 2 effectiveness-implementation trial date = 2020-08-17 keywords = bundle; implementation; nvhap; study summary = title: Implementation and evaluation of a care bundle for prevention of non-ventilator-associated hospital-acquired pneumonia (nvHAP) – a mixed-methods study protocol for a hybrid type 2 effectiveness-implementation trial A longitudinal, qualitative study and formative evaluation based on interviews, focus groups, and observations identifies supporting or hindering factors for implementation success in participating departments dynamically over time. DISCUSSION: This comprehensive hybrid mixed-methods study is designed to both, measure the effectiveness of a new nvHAP prevention bundle and multifaceted implementation strategy, while also providing insights into how and why it worked or failed. This comprehensive type 2 hybrid effectivenessimplementation study aims to assess the effectiveness and success factors of both, a new prevention bundle against nvHAP and a specifically designed departmentbased multifaceted implementation strategy in a medical and surgical patient population. doi = 10.1186/s12879-020-05271-5 id = cord-291851-xesef17i author = Wong, Yu-Jun title = A systematic review and meta-analysis of the COVID-19 associated liver injury date = 2020-08-31 keywords = covid-19; liver; study summary = Our meta-analysis aims to compare the risks and clinical outcomes of COVID-19 associated liver injury among adults with severe and non-severe COVID-19. The objective of this meta-analysis is to compare the risk and clinical outcome of COVID-19 associated liver injury between COVID-19 patients with severe and non-severe COVID-19. In this meta-analysis, we included all studies that met the following inclusion criteria: (1) population: adult patients infected with the COVID-19, (2) reported outcome data on liver enzymes derangement (3) reported outcome data on the risk or severity of liver injury between severe and non-severe COVID-19. We extracted data on the demographic of study populations (age, gender, sample size, the proportion of subjects with baseline chronic liver disease and the use of Lopinavir/ritonavir) as well as the pattern of COVID-19 associated liver injury (ALT, AST, bilirubin, albumin and GGT) from all included studies. and performed a meta-analysis on the severity and risk of COVID-19 associated liver injury in these patients. doi = 10.1016/j.aohep.2020.08.064 id = cord-030679-27qrlapp author = Yamamoto, Ryo title = Oxygen administration in patients recovering from cardiac arrest: a narrative review date = 2020-08-12 keywords = hyperoxia; oxygen; study summary = In this review, we described the concept of brain injury following CA, the pathophysiology of hyperoxia, clinical studies of hyperoxia, the practical adjustment of oxygen administration, and ventilatory strategies for resuscitated patients. Although extensive research on improvement of clinical outcomes of patients recovering from CA has been conducted, the literature regarding post-cardiac arrest care practices to prevent neuronal cell dysfunction is limited [20] [21] [22] [23] . [8] conducted a systematic review and meta-analysis of eight retrospective studies, including those we mentioned above, and revealed that hyperoxia, defined as PaO 2 > 300 mmHg, correlated with increased in-hospital mortality (OR: 1.40 [1.02-1.93]), compared with normoxia. Several retrospective studies, a prospective observational study, and two systematic reviews demonstrated that exposure to PaO 2 > 300 mmHg during post-CA care is associated with unfavorable clinical outcomes, although the results are inconsistent. Study of Oxygen in Critical Care (SOCC) Group Arterial hyperoxia and in-hospital mortality after resuscitation from cardiac arrest doi = 10.1186/s40560-020-00477-w id = cord-263322-y4htkvux author = Yang, Jun title = Association between genetic polymorphisms and osteonecrosis in steroid treatment populations: a detailed stratified and dose-response meta-analysis date = 2019-05-14 keywords = ABCB1; SONFH; study summary = title: Association between genetic polymorphisms and osteonecrosis in steroid treatment populations: a detailed stratified and dose-response meta-analysis The studies were included in our meta-analysis if they met the following criteria: (1) case-control or cohort studies comparing a population that suffered SONFH with a population that did not suffer after steroid treatment, (2) studies assessing the associations between genetic polymorphisms and SONFH, and (3) studies reporting the frequencies of specific alleles or the effect sizes of individual genotypes between cases and controls. First, the present study found that the ABCB1 rs1045642 mutation has a protective effect on SONFH, and the risk will be further reduced with increasing cumulative steroid dosage. Genetic association of the P-glycoprotein gene ABCB1 polymorphisms with the risk for steroid-induced osteonecrosis of the femoral head in Chinese population doi = 10.1042/bsr20190024 id = cord-265723-6k8196p2 author = Yu, Chengjun title = Evaluation of safety, efficacy, tolerability, and treatment-related outcomes of type I interferons for Human coronaviruses (HCoVs) infection in clinical practice: An updated critical systematic review and meta-analysis date = 2020-06-25 keywords = IFN; SARS; study summary = title: Evaluation of safety, efficacy, tolerability, and treatment-related outcomes of type I interferons for Human coronaviruses (HCoVs) infection in clinical practice: An updated critical systematic review and meta-analysis Therefore, we conducted this updated systematic review and meta-analysis to recapitulate relevant studies to evaluate the safety, efficacy, tolerability and treatment-related outcomes of type I IFNs for coronavirus infection in clinical practice, with expectation to provide more robust evidence whether IFNs should be served as first-line agents for coronavirus infection, including the SARS-CoV-2. Each included article was thoroughly reviewed, and the following baseline information were extracted (Table 1) : first author, publication year, region, study type, participants, diagnostic method of coronavirus, data collection method, time from admission to treatment start, time from diagnosis to treatment start, primary endpoints, and treatment-related adverse effects. Critically ill defined as coronavirus-infected patients with other severe comorbidities, respiratory distress or failure, directly or indirectly transferred to ICU, needing intubation, mechanical ventilation, or extracorporeal membrane oxygenation (ECMO), when admitted to primary treatment. doi = 10.1016/j.intimp.2020.106740 id = cord-265139-x7g3jcjm author = Zaiou, Mohamed title = The Emerging Role and Promise of Circular RNAs in Obesity and Related Metabolic Disorders date = 2020-06-16 keywords = RNA; circrna; circular; obesity; study summary = There is also growing evidence that circRNAs are closely linked to non-alcoholic fatty liver disease (NAFLD), a disorder that is caused by a plethora of factors including hepatic lipid accumulation, adipose tissue and mitochondrial dysfunction, a high-fat diet, obesity, a chronic inflammatory state, insulin resistance (IR), and genetic and epigenetic factors [48, 55] . In addition to classical epigenetic modifications, a variety of ncRNAs have been uncovered in different cells and organs including adipose tissues, many of which are involved in the regulation of adipogenesis and other metabolic processes implying their role in the etiology of obesity [69] . Emerging evidence from in vitro and in vivo animal studies suggest that circRNAs are expressed in adipose tissues and may modulate adipogenesis and lipid metabolism. Collectively, the results from the above studies demonstrate that several circRNAs are differentially expressed in adipose tissue and support a significant role of these RNA species in the regulatory networks of adipogenesis. doi = 10.3390/cells9061473 id = cord-012778-yr8zuvw9 author = Zhang, Lei title = Quantitative efficacy of three antipsychotic drugs for schizophrenia based on a real-world study in China date = 2019-08-06 keywords = antipsychotic; patient; study summary = We quantified the time course of PSP improvement in patients after treatment with these three antipsychotics: olanzapine, risperidone, and aripiprazole reached an E(max) value of 80.3%, 68.2%, and 23.9% at weeks 56.7, 29.2, and 36.8, respectively. In addition, quantitative information on the long-term social functioning of schizophrenic patients treated with SGAs is scarce in current clinical practice [12, 13] , and the available information does not reflect the differences in therapeutic efficacies between various drugs. Using data from the Study of Long-term Outcomes for Schizophrenia by Atypical Antipsychotic Treatment in China (SALT-C) study, which is a multicenter, real-world clinical study, we examined the differences in efficacy between three antipsychotics (olanzapine, risperidone, and aripiprazole) to provide a guide for clinicians when choosing an antipsychotic for the individualized treatment of schizophrenia. The SALT-C study was registered at https://www.clinicaltrials.gov (identifier: NCT02640911) and produced a large data set of real-world schizophrenia patients in China recruited in an open-label 3-year follow-up clinical trial of widely used atypical antipsychotics. doi = 10.1038/s41401-019-0285-x id = cord-316126-j51dik7f author = Zhang, X. Sophie title = SARS-CoV-2 and Health Care Worker Protection in Low-Risk Settings: a Review of Modes of Transmission and a Novel Airborne Model Involving Inhalable Particles date = 2020-10-28 keywords = COVID-19; CoV-2; N95; PPE; SARS; mask; study; transmission summary = title: SARS-CoV-2 and Health Care Worker Protection in Low-Risk Settings: a Review of Modes of Transmission and a Novel Airborne Model Involving Inhalable Particles Since the beginning of the COVID-19 pandemic, there has been intense debate over SARS-CoV-2''s mode of transmission and appropriate personal protective equipment for health care workers in low-risk settings. This review attempts to summarize current cumulative data on SARS-CoV-2''s modes of transmission and identify gaps in research while offering preliminary answers to the question on everyone''s mind: is the airborne route significant and should we modify our COVID-19 PPE recommendations for frontline workers in low-risk settings? Given that substantial disagreement persists on the importance of natural aerosol generation by COVID-19 patients, and consequently, the necessary level of respiratory protection in non-AGP contexts, our review will focus on transmission and PPE in low-risk health care settings. doi = 10.1128/cmr.00184-20 id = cord-351530-crsii3pu author = Zhao, Fuqiang title = Caring for the Caregiver during COVID-19 Outbreak: Does Inclusive Leadership Improve Psychological Safety and Curb Psychological Distress? A Cross-sectional Study date = 2020-07-30 keywords = distress; inclusive; leadership; psychological; study summary = DESIGN: Cross-Sectional Study with Temporal Separation SETTINGS AND PARTICIPANTS: The researchers recruited 451 on-duty registered nurses from 5 hospitals providing patient care during the highly infectious phase of COVID-19 in January 2020 in Wuhan city, the epicentre of the outbreak in China METHODS: After obtaining permission from hospital administration, data were collected through an online questionnaire survey in three stages with temporal separation to avoid common method bias. Multi-group analysis results indicate no significant differences between respondents based on these control variables CONCLUSIONS: Recurring or prolonged experiences of stress and anxiety at the workplace, without a mechanism to counter such effects, can culminate into psychological distress. Inclusive leadership is one of the positive leadership styles studied in this paper due to its impact on the psychological distress of nurses working during the COVID-19 epidemic. doi = 10.1016/j.ijnurstu.2020.103725 id = cord-004385-xna32qve author = Zhou, Yuqing title = Use of corticosteroids in influenza-associated acute respiratory distress syndrome and severe pneumonia: a systemic review and meta-analysis date = 2020-02-20 keywords = ARDS; corticosteroid; study summary = title: Use of corticosteroids in influenza-associated acute respiratory distress syndrome and severe pneumonia: a systemic review and meta-analysis We obtained the following data: (a) characteristics of studies (design, setting, country, period, methodological details for quality assessment); (b) characteristics of participants (demographics, co-morbid illnesses, disease severity, numbers in each group, influenza virus type); (c) characteristics of interventions (type, dose, timing and duration of corticosteroid use); and (d) outcomes. Another study reporting the result of 62 patients with acute respiratory failure due to influenza showed no statistically significant difference between low dose and high dose corticosteroid therapy (8/19 versus 7/19, p > 0.05) 16 . The overall findings of this meta-analysis indicated that patients with pneumonia or acute respiratory distress syndrome who were administered corticosteroids had significantly higher mortality and incidence of nosocomial infection but the use of corticosteroids did not influence the length of hospital stay. doi = 10.1038/s41598-020-59732-7 id = cord-286411-7sgr29xx author = Zhou, Zibanai title = Critical shifts in the global tourism industry: perspectives from Africa date = 2020-10-06 keywords = Africa; BRICS; UNWTO; global; international; market; study; tourism summary = Drawing upon a sample of thirty tourism experts in southern Africa, the critical shifts were identified and key among them include BRICS, terrorism, ageing population, and trophy hunting, are increasingly framing a new narrative for the future growth trajectory of the international tourism industry''s value chain in the context of Africa. Whilst acknowledging the diverse and richness of the current international tourism body of literature, the current study argues that very little attempts have been made to explore the policy and product development implications of the constructs of BRICS, terrorism, ageing population and trophy hunting in the context of Africa. Looking into the future, there is substantial room for growth in Africa''s travel and tourism market, particularly in light of current sectoral growth patterns, as international tourists are increasingly interested in developing countries as travel destinations, provide the region properly align its tourism sector to dynamics obtaining in the marketplace. doi = 10.1007/s10708-020-10297-y id = cord-336306-hvy9ukhh author = Zhu, Jieyun title = Clinical characteristics of 3,062 COVID‐19 patients: a meta‐analysis date = 2020-04-15 keywords = patient; study summary = The inclusion criteria were as follows: (1) Cohort studies, case-control studies and case series studies; (2) The study population included individuals diagnosed with COVID-19; (3) The primary outcomes were: clinical symptoms, signs, laboratory and imaging results; the secondary outcomes were the incidence of respiratory failure(RF) or acute respiratory distress syndrome (ARDS), fatality rate, etc. The exclusion criteria were as follows: (1) Overlapping or duplicate studies; (2) The epidemiological analysis with only secondary outcomes such as fatality rate, without the primary outcomes; (3) Had no clinical indicators or lacking necessary data; (4) Case reports and studies with a sample size less than 10. After a detailed assessment based on the inclusion criteria, 38 studies involving 3 062 COVID-19 patients were included in this meta-analysis ( Fig. 1 ). There were 8 studies reported the incidence of RF or ARDS in COVID-19 patients.The random-effects model was used in the meta-analysis, which showed that the incidence of RF or ARDS was 19.5% (95%CI 5% -40.3%) ( Table 3 ). doi = 10.1002/jmv.25884 id = cord-000083-3p81yr4n author = nan title = Poster Exhibition date = 2009-01-31 keywords = ADV; AFP; Background; CHB; China; DNA; ETV; HBV; HCC; HCV; Hepatitis; Hospital; IFN; LAM; NAFLD; NASH; PCR; RFA; RNA; SVR; University; aim; alt; cell; conclusion; group; level; liver; method; patient; result; study; treatment summary = R. China Background: The objective of this study was to evaluate the early virologic response for prediction of achievement of HBeAg seroconversion and hepatitis B virus (HBV) DNA negativity after two years of lamivudine treatment in chronic hepatitis B (CHB) patients. Methods: A total of 620 patients who tested positive for hepatitis B surface antigen and were referred to Chiba University Hospital between February 1985 and March 2008 were included in the study, and their following characteristics were analyzed: age, gender, the status of HBeAg, ALT, HBV-DNA level, and PLT. Methods: A total of 60 patients with chronic hepatitis B, 32 (53.3%) were HBeAg positive (group A) while 28(46.7%) were HBeAg negative (group B) were included in this study after meeting the following criteria: age 18 to 60 years, HBsAg positive for more than 6 months, serum HBV-DNA was >5 log(10) copies/mL and ALT more than two times the upper normal limit. doi = 10.1007/s12072-009-9123-4 id = cord-000718-7whai7nr author = nan title = ESP Abstracts 2012 date = 2012-08-22 keywords = ALK; BRAF; CD10; CD34; CK7; CRC; Dept; EBV; EGFR; HCC; HER2; Hodgkin; Hospital; IHC; KRAS; Ki-67; Ki67; MSI; Medical; NSCLC; Objective; PCR; Pathology; Turkey; University; cancer; carcinoma; case; cell; conclusion; diagnosis; dna; expression; fish; high; method; patient; primary; result; study; tissue; tumor summary = Method: We analyzed consecutive gastric cancer cases in terms of AMACR immunohistochemical expression and clinical/pathological characteristics and followed patients'' postoperative history. Results: Histological, immunohistochemical and molecular examination revealed non-neoplastic lymphadenopathy with atypical paracortical T-cell hyperplasia with immunoblastic reaction in the former and burnt-out histiocytic pattern in the latter, both falling into a broad spectrum of reactive lymph node changes associated with Still''s disease. Method: We have thus collected, from our two Institutions a large number (45 cases) of cancers showing the histological definition of adenosquamous carcinomas according to the WHO criteria and performed gene analysis for k-RAS (codons 12, 13) and EGFR (codons 18, 19 and 21) mutations. Objective: We previously identified amplified fibroblast growth factor 1 (FGFR1) as a therapeutic target for small molecule inhibitor (SMI) therapy in squamous cell lung cancer (L-SCC), resulting in currently running clinical trials treating patients with stage III disease. doi = 10.1007/s00428-012-1284-1 id = cord-000977-ka4261wc author = nan title = ECR 2013 Book of Abstracts - B - Scientific Sessions date = 2013-03-07 keywords = ADC; CAD; CNR; DCE; DWI; FBP; FDG; MDCT; MRI; PET; SNR; Siemens; conclusion; group; high; image; material; mean; method; patient; purpose; result; study summary = Methods and Materials: Mean attenuation, contrast-to-noise ratio (CNR) and signal-to-noise ratio (SNR) at abdominal aorta, right renal artery (RRA) and left renal artery (LRA) were measured in 24 kidney donors who had undergone CTA with tube current modulation, 120 kVp, filtered back projection reconstruction algorithm (Group A) and were compared with 24 BMI-matched kidney donors who had undergone CTA with automated kVp selection and SAFIRE (Group B Purpose: Cerebral small vessel disease (SVD) is a common cause of cognitive impairment. Overall average score of SSF reconstructed segments was significantly higher compared with STD reconstruction ( Purpose: To evaluate the feasibility and imaging quality of double prospectively ECG-triggered high-pitch spiral acquisition mode for coronary computed tomography angiography (CTCA) in patients with atrial fibrillation (AF). doi = 10.1007/s13244-013-0228-x id = cord-001221-due9tloa author = nan title = ECR 2014, Part A date = 2014-02-27 keywords = ASL; CTA; DWI; Europe; FDG; GGO; MDCT; MRI; PET; RADS; RECIST; SPECT; base; cancer; clinical; contrast; diagnosis; different; disease; european; high; image; imaging; lesion; objective; patient; radiologist; role; study; technique; treatment; tumour summary = In short: obtaining samples for making an accurate diagnosis and also to know more about its specific biology (biomarkers); IR covers any possibility needed for vascular access; percutaneous needle ablation is the best alternative in selected patients; endovascular embolisation with "vehiculisation" of therapies is an outstanding method for selective treatment, and sometimes precise ablation, of different tumors; IR is a unique way to offer palliation in a wide range of tumoral complications, such as embolisation for bleeding, stenting for vein obstructions or drainage of fluid collections. CT may be useful for osteoid osteoma and MRI is the best imaging technique for further diagnosis and staging by displaying tumour composition and extent of bone marrow involvement, including skip lesions, presence and extent of extraosseous soft tissue mass, and involvement of neurovascular bundle, muscle compartments and adjacent joint. doi = 10.1007/s13244-014-0316-6 id = cord-001835-0s7ok4uw author = nan title = Abstracts of the 29th Annual Symposium of The Protein Society date = 2015-10-01 keywords = ATP; Biology; Ca21; Chemistry; Department; Institute; NADPH; NMR; PDB; RNA; Science; Tau; University; activity; base; bind; binding; cell; change; complex; design; dna; domain; enzyme; form; function; high; interaction; membrane; method; molecular; peptide; process; protein; residue; result; role; sequence; site; structure; study summary = Altogether, these results indicate that, although PHDs might be more selective for HIF as a substrate as it was initially thought, the enzymatic activity of the prolyl hydroxylases is possibly influenced by a number of other proteins that can directly bind to PHDs. Non-natural aminoacids via the MIO-enzyme toolkit Alina Filip 1 , Judith H Bartha-V ari 1 , Gergely B an oczy 2 , L aszl o Poppe 2 , Csaba Paizs 1 , Florin-Dan Irimie 1 1 Biocatalysis and Biotransformation Research Group, Department of Chemistry, UBB, 2 Department of Organic Chemistry and Technology An attractive enzymatic route to enantiomerically pure to the highly valuable a-or b-aromatic amino acids involves the use of aromatic ammonia lyases (ALs) and aminomutases (AMs). Continuing our studies of the effect of like-charged residues on protein-folding mechanisms, in this work, we investigated, by means of NMR spectroscopy and molecular-dynamics simulations, two short fragments of the human Pin1 WW domain [hPin1(14-24); hPin1(15-23)] and one single point mutation system derived from hPin1(14-24) in which the original charged residues were replaced with non-polar alanine residues. doi = 10.1002/pro.2823 id = cord-002774-tpqsjjet author = nan title = Section II: Poster Sessions date = 2017-12-01 keywords = AIDS; Canada; Centre; City; Community; HCV; HIV; Health; India; MSM; National; New; Toronto; Vancouver; York; access; african; age; care; child; datum; drug; group; high; introduction; method; need; patient; population; poster; program; research; result; service; session; social; study; urban; woman; year summary = Results: The CHIP Framework The CHIP framework aims to improve the health and wellness of the urban communities served by St. Josephs Health Centre through four intersecting pillars: • Raising Community Voices provides an infrastructure and process that supports community stakeholder input into health care service planning, decision-making, and delivery by the hospital and across the continuum of care; • Sharing Reciprocal Capacity promotes healthy communities through the sharing of our intellectual and physical capacity with our community partners; • Cultivating Integration Initiatives facilitates vertical, horizontal, and intersectoral integration initiatives in support of community-identified needs and gaps; and • Facilitating Healthy Exchange develops best practices in community integration through community-based research, and facilitates community voice in informing public policy. doi = 10.1093/jurban/jti137 id = cord-003532-lcgeingz author = nan title = 39th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium, 19-22 March 2019 date = 2019-03-19 keywords = AKI; APACHE; ARDS; AUC; Care; Critical; DIC; ECMO; Fig; Hospital; ICU; Intensive; LOS; MAP; conclusion; figure; group; high; introduction; level; method; mortality; patient; result; score; sofa; study; table summary = It''s proposed to evaluate the association between myocardial injury biomarkers, high-sensitive troponin T (hs-cTnT) and N-terminal pro-brain natriuretic peptide (NT-ProBNP), with inflammatory mediators (IL-6, IL-1Β , IL-8, IL-10, IL-12 / IL-23p40, IL17A, IL-21 and TNF-α ) and biomarkers, C protein reactive (CPR) and procalcitonin (PCT), in septic patients Methods: This was a prospective cohort study performed in three intensive care units, from September 2007 to September 2010 enrolling patients with sepsis (infection associated with organ dysfunction), and septic shock (hypotension refractory by fluids infusion requiring vasopressor). Blood samples were collected up to 48h after the development of first organ dysfunction (D0) and on the 7th day after inclusion in the study (D7) Results: Ninety-five patients were enrolled, with median age 64 years (interquatile?48-78), APACHE II: median 19 (14-22), SOFA: median 8 (5-10); 24.2% were admitted in ICU with sepsis and 75.8% with septic shock. doi = 10.1186/s13054-019-2358-0 id = cord-004534-jqm1hxps author = nan title = Abstract date = 2009-06-09 keywords = AFM; ATP; Biology; Biophysics; Chemistry; Department; FCS; France; GFP; Genova; Germany; Hyp; Institute; Italy; Molecular; Physics; RNA; Sciences; University; cell; dna; fluorescence; fret; interaction; lipid; membrane; protein; result; structure; study summary = HIV-1 to efficiently complete a replication cycle has to integrate its genome into the host cellular DNA.After HIV-1 enters target cells,neosynthesized viral DNA forms along with other proteins the pre-integration complex (PIC).PICs are then transported into the nucleus where integration,catalyzed by the viral integrase,takes place.HIV-1 viral particles engineered to incorporate integrase fused to EGFP have proven effective to study PICs within nuclei of infected cells.In this study we report the live imaging analysis of nuclear PIC dynamics obtained by time-lapse microscopy.Intranuclear trajectories of IN-EGFP-labeled PIC were collected in three dimensions and examined by both mean squared displacement (MSD) and cage diameter (CD) analysis.In CD the maximum distances measured between two positions occupied by a PIC in a time window of 2 minutes were calculated while in our MSD analysis 5-minute long trajectory segments were considered.Remarkably,MSD revealed the presence of an underlying active transport mechanism.To test the possible role of actin filaments,PIC nuclear trafficking was analyzed in cells treated with latrunculin B (actin polymerization inhibitor).Preliminary results suggest that the disruption of actin function impairs the active nuclear movement of PICs. Second harmonic generation microscopy reveals sarcomere contractile dynamics of cardiomyocytes N. doi = 10.1007/s00249-009-0478-1 id = cord-004584-bcw90f5b author = nan title = Abstracts: 8th EBSA European Biophysics Congress, August 23rd–27th 2011, Budapest, Hungary date = 2011-08-06 keywords = AFM; ATP; Biophysics; Department; FCS; Germany; Institute; RNA; University; cell; change; channel; complex; different; dna; dynamic; effect; fluorescence; fret; high; interaction; lipid; mechanism; membrane; model; molecular; molecule; process; protein; result; structure; study; surface; system summary = Our goals are two-fold: (1) to monitor conformational changes in each domain upon its binding to specific ligands and then to correlate the observed changes with structural differences between the CRDs and (2) to investigate the interaction between the CRDs and lipid model membranes. Cholesterol-assisted lipid and protein interactions such as the integration into lipid nanodomains are considered to play a functional part in a whole range of membrane-associated processes, but their direct and non-invasive observation in living cells is impeded by the resolution limit of [200nm of a conventional far-field optical microscope. Therefore, to investigate the dynamic and complex membrane lateral organization in living cells, we have developed an original approach based on molecule diffusion measurements performed by fluorescence correlation spectroscopy at different spatial scales (spot variable FCS, svFCS) (1). doi = 10.1007/s00249-011-0734-z id = cord-004879-pgyzluwp author = nan title = Programmed cell death date = 1994 keywords = ATP; Basel; Bern; Drosophila; Institut; Lausanne; NMDA; PCR; PKC; RNA; Switzerland; TNF; University; acid; activity; cell; dna; expression; gene; high; human; increase; level; mouse; protein; receptor; result; sequence; study; type summary = Furthermore kinetic experiments after complementation of HIV=RT p66 with KIV-RT pSl indicated that HIV-RT pSl can restore rate and extent of strand displacement activity by HIV-RT p66 compared to the HIV-RT heterodimer D66/D51, suggesting a function of the 51 kDa polypeptide, The mouse mammary tumor virus proviral DNA contains an open reading frame in the 3'' long terminal repeat which can code for a 36 kDa polypeptide with a putative transmembrane sequence and five N-linked glycosylation sites. To this end we used constructs encoding the c-fos (and c-jun) genes fused to the hormone-binding domain of the human estrogen receptor, designated c-FosER (and c-JunER), We could show that short-term activation (30 mins.) of c-FosER by estradiole (E2) led to the disruption of epithelial cell polarity within 24 hours, as characterized by the expression of apical and basolateral marker proteins. doi = 10.1007/bf02033112 id = cord-004894-75w35fkd author = nan title = Abstract date = 2006-06-14 keywords = ABSTRACT; BMI; Background; CHD; CVD; Germany; Health; Methods; Netherlands; age; cancer; conclusion; datum; discussion; dutch; european; factor; high; increase; objective; patient; result; risk; study; woman; year summary = The unadjusted median (25-75% percentile) sperm concentration in the non-exposed group (n = 90) is 49 (23-86) mill/ml compared to 33 (12-63) mill/ml among men exposed to >19 cigarettes per day in fetal life (n = 26 Aim: To estimate the prevalence of overweight and obesity, and their effects in physical activity (PA) levels of Portuguese children and adolescents aged 10-18 years. Objectives: a) To estimate the sex-and age-adjusted annual rate of tuberculosis infection (ARTI) (per 100 person-years [%py]) among the HCWs, as indicated by tuberculin skin test conversion (TST) conversion, b) to identify occupational factors associated with significant variations in the ARTI, c) to investigate the efficacy of the regional preventive guidelines. Objectives: We assessed the total burden of adverse events (AE), and determined treatment-related risk factors for the development of various AEs. Methods: The study cohort included 1362 5-year survivors, treated in the Emma Childrens Hospital AMC in the Netherlands between 1966-1996. doi = 10.1007/s10654-006-9021-1 id = cord-004948-ad3i9wgj author = nan title = 7th International Congress on Amino Acids and Proteins : Vienna, Austria, August 6–10, 2001 date = 2001 keywords = Department; GABA; HPLC; Institute; Japan; NMDA; Research; Sciences; Tau; University; acid; activity; amino; cell; dna; effect; increase; level; protein; rat; result; study; taurine summary = Specific CTL were derived by immunization of HHD mice with tumor peptide extracts loaded on antigen presenting cells and with HHD transfected human tumor cell lines CTL induced against peptides from various tumors recognized tumor peptides more effectively than peptides extracted from normal tissues and also reacted with a serie of peptides derived from overexpressed candidate proteins, identified by differential display methods (SAGE, Microarrays) Comparison of CTL derived from HHD mice to CTL induced from patient''s PBMC showed overlapping recognition of many candidate peptides. By comparison of pro-teomic cell maps from normal controls and individuals affected with lysosomal transport disorders we have selected and identified several candidate disease-causing proteins, which have to be further studied by mutation analysis and functional expression. The results of the in vitro studies available to date strongly suggest that its effects on neuronal amino acid transport processes is mediated via some novel extracellular mechanism controlling the H ϩ (and/or other ionic) concentrations of neurones. doi = 10.1007/s007260170030 id = cord-005105-twsy61oq author = nan title = SIU 2015 Abstracts date = 2015-09-21 keywords = ADT; BPH; ESWL; Gleason; Group; Hospital; IPSS; Introduction; January; LUTS; MRI; Objective; PCNL; PSA; Prostate; RARP; TRUS; aft; bladder; case; conclusion; follow; mean; method; patient; renal; result; score; signifi; study; treatment; urinary; year summary = Th e present study is based on a retrospective analysis of a database of over 600 patients (age range 17-57 years) who met the consensus criteria for bacterial prostatitis, 75% of whom had dysuria, 35% perineal discomfort, 60% had obstructive luts, 37% infertility of unknown etiology, 10% erectile dysfunction and 25% recurrent infection of the partner. Further research is needed to determine to assess whether localization of small volume disease on 68Ga-PSMA PET/CT can improve diagnostic algorithms and outcomes in patients with recurrent PCa. Introduction and Objective: To assess long-term results of salvage pelvic lymph node dissection (PLND) in prostate cancer (PC) patients (pts) with biochemical recurrence aft er primary local treatment and confi rmed solitary lymph node (LN) metastases. doi = 10.1007/s00345-015-1684-3 id = cord-005147-mvoq9vln author = nan title = Autorenregister date = 2017-02-23 keywords = Berlin; Genetics; Germany; Human; Illumina; Institute; NGS; PCR; RNA; Sanger; University; WES; analysis; case; cell; disease; dna; expression; family; gene; mutation; patient; result; sequencing; study; syndrome; variant summary = Using whole-exome sequencing and trio-based de novo analysis, we identified a novel heterozygous de novo frameshift variant in the leukemia inhibitory factor receptor (LIFR) gene causing instability of the mRNA in a patient presenting with bilateral CAKUT and requiring kidney transplantation at one year of age. Loss of cdkl5 associated with deficient mammalian target of rapamycin (mTOR) signaling in mice and human cells We and other groups have shown that mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene cause a severe neurodevelopmental disorder with clinical features including intellectual disability, early-onset intractable seizures and autism, that are closely related to those present in Rett syndrome (RTT) patients. Functional characterization of novel GNB1 mutations as a rare cause of global developmental delay Over the past years, prioritization strategies that combined the molecular predictors of sequence variants from exomes and genomes of patients with rare Mendelian disorders with computer-readable phenotype information became a highly effective method for detecting disease-causing mutations. doi = 10.1007/s11825-017-0126-6 id = cord-005497-w81ysjf9 author = nan title = 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 date = 2020-03-24 keywords = AKI; AUC; CRP; CRRT; Care; Critical; ECMO; Fig; Hospital; ICU; IQR; Intensive; LOS; LPS; OHCA; PCT; ROC; TBI; Unit; University; VAP; blood; day; figure; group; high; introduction; mortality; patient; result; sepsis; sofa; study; table summary = The positive NC group had more plasma transfusion (p-value 0.03) and a lower median hematocrit at 24 hrs (p-value 0.013), but similar hospital length of stay (p=0.17) and mortality rate (p=0.80) Conclusions: NC at ICU admission identifies subclinical AKI in TBI patients and it maight be used to predictclinical AKI. In patients with pneumonia requiring intensive care (ICU) admission, we hypothesise that abnormal right ventricular (RV) function is associated with an increased 90-day mortality. The objective of this study was to describe the incidence of each AKI stages as defined by KDIGO definition (with evaluation of urine output, serum creatinine and initiation of renal replacement therapy (RRT)), in a mixed medical and surgical population of patients hospitalized in ICU and PCU over a 10-year period (2008-2018). This study aimed at investigating the relationship of goal-directed energy and protein adequacy on clinical outcomes which includes mortality, intensive care unit(ICU) and hospital length of stay (LOS), and length of mechanical ventilation (LOMV). doi = 10.1186/s13054-020-2772-3 id = cord-005646-xhx9pzhj author = nan title = 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date = 1996 keywords = ARDS; CPB; Care; Children; ECMO; Hospital; ICU; Intensive; PICU; Pediatric; Unit; age; blood; case; child; conclusion; day; failure; group; high; hour; increase; infant; level; mean; method; patient; prism; pulmonary; respiratory; result; severe; study; ventilation; year summary = Aims and methods The aim of both a prospective and retrospective survey conducted in German pediatric intensive care units in 1993 was to accumulate data on the epidemiology, risk factors, natural history and treatment strategies in a large group of pediatric ARDS patients who were treated in the tt~ee year period from 1991 to 1993.All patients had acute bilateral alveolar infiltration of noncardiogenic origin and a pO2~iO2 ratio < 150mmHg. The influence of sex, underlying disease and single organ failure was analyzed using the Fischer''s exact test, the influence of additional organ failure on mortality was tested with the Cochran-Mantel-Haenszet statistics. doi = 10.1007/bf02316512 id = cord-005727-li8pwigg author = nan title = ESICM 2010 MONDAY SESSIONS 11 October 2010 date = 2010-08-31 keywords = AKI; APACHE; CRP; Care; GCS; Hospital; ICP; ICU; Intensive; January; LPS; NIV; PCT; Unit; University; VAP; conclusion; day; group; introduction; method; objectives; patient; result; sofa; study summary = Since, continuous epidural analgesia provides the required level of analgesia to support early mobilization and significant reduction in pulmonary and cardiovascular morbidity in the early postoperative period, we postulated that the use of low dose of continuous epidural morphine might improve postoperative analgesia and reduce undesirable side effects in elderly patientsTherefore, the present study was designed to evaluate the effects of morphine administered via epidural patients controlled analgesia and intravenous tramadol + metamizol on postoperative pain control and side effects in elderly patients after major abdominal surgery. For each ventilated patient the following data was registered:Age, APACHE II, the reason of admission, risk factors, use NIV, MV duration, timing of tracheostomy, time of diagnosis of VAP, microbiological data, length of stay and mortality in ICU. 23rd ESICM ANNUAL CONGRESS -BARCELONA, SPAIN -9-13 OCTOBER 2010 S131 Evaluated factors: patient characteristics, signs, symptoms, abscess location, time between symptoms and hospital admission and surgery, lab results, microbiology, antibiotic therapy, APACHE2, SAPS2, SOFA, length of ICU stay, surgical re-intervention, duration of mechanical ventilation, infectious complications, critical illness myopathy (CIM), renal replacement therapy (RRT), re-intubation, tracheotomy, mortality. doi = 10.1007/s00134-010-1999-x id = cord-005777-6rvfsx4p author = nan title = PS 0420-0716 date = 2007-08-25 keywords = APACHE; ARDS; CVVH; Care; GCS; Glasgow; Hospital; ICP; ICU; Intensive; TEG; VAP; conclusion; day; group; mean; method; mortality; patient; peep; result; study summary = We prospectively recorded data of all patients who were newly diagnosed with AF and all those with a septic shock on a surgical ICU (no cardiac surgery) during a one year period according to the requirements of the local ethical committee. Our aim was to evaluate the predictive role of admission APACHE II, admission and total maximum SOFA score, hypoalbuminemia, increased serum creatinine, C-reactive protein, lactate, and serum blood glucose for the 30-day mortality of septic patients admitted to medical ICU. The aim of this study was to analyze the clinical presentation and to evaluate mortality associated factors (timing and accurancy of diagnosis, timing of surgery, severity score and organ failure, surgical and medical treatments). Data were extracted independently to assess intention to treat intensive care unit (ICU) and hospital mortality, days of mechanical ventilation, length of stay, incidence of ventilator-associated pneumonia and pneumothorax, and associated complications of the implemented intervention. doi = 10.1007/s00134-007-0823-8 id = cord-005814-ak5pq312 author = nan title = 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date = 1995 keywords = AMI; APACHE; ARDS; ARF; COPD; CPB; CPR; CVP; Care; ECG; ECMO; Group; H20; Hospital; ICP; ICU; III; IL-6; Intensive; January; LPS; MOF; PSV; SAPS; TNF; Unit; University; acute; blood; cardiac; change; conclusion; control; day; effect; failure; follow; high; hour; increase; level; mean; measure; method; mortality; objective; patient; peep; pressure; pulmonary; respiratory; result; study; treatment; value summary = Results: In 5 patients with treated SS, 16 tests were performed (VL n=8; Dobu n=4; NA n=4 Method: Septic shock was defined as severe sepsis with either persistent hypotension (mean arterial pressure; MAP<70 mmHg) or the requirement for a noradrenaline (NA) infusion ~> 0.1 ~g/kg/min with a MAP _< 90mmHg. Cardiovascular support was limited to NA + dobutamine (DB), 546C88 was administered for up to 8 h at a fixed dose-rate of either i, 2.5, 5, 10 or 20 mg/kg/h iv. Methods: Fourteen cases were s~udied,their gestational age ranged from(27-32)ws.Continnous positive air way pressure was applied to six cases at Peep level from (3-6)cm H2o through nasal pronge,(group I),the other 8 cases were managed as routine,(group II).Blood gases, TcPO2,TcCo2,resp.rate,depth and pattern were monitored for assessment of tissue Oxygenation and ventilation, Results: Our rasults showed that early application of CPAP improve ventilation among (83.3%)of cases,while (16.7%)of cases need IMV.The cases of group II need IMV among (75%)of the studied cases during the second or the third day of life. doi = 10.1007/bf02426401 id = cord-005816-i54q5gsu author = nan title = 10(th) European Congress of Trauma and Emergency Surgery: May 13–17, 2009 Antalya, Turkey date = 2009-08-06 keywords = Department; GCS; Hospital; ICU; ISS; Istanbul; January; Turkey; University; abdominal; case; conclusion; day; fracture; group; injury; introduction; method; mortality; patient; result; score; study; surgery; trauma; treatment; year summary = Several factors such as the initial lack of symptoms, a low diagnostic sensitivity of the CT (34% false negatives), and the nonoperative management of solid organ injuries, have contributed to a delayed diagnosis in one of every five patients in our series, but this has not led to a significant increase in septic complications in this group. Method: The demographic features, the treatments, the intensity of the illness and mortality rate of the 155 patients in Afyon Kocatepe University General Surgery clinic between the years 2006 Background: Enterocutaneous fistula continues to be a serious surgical problem. Introduction: In our previous study, we examined the treatment results of burn patients older than 45 years, and found a significant increase in mortality with increasing age groups. Methods: Data on emergency surgical cases and admissions to the surgical service over a 3-month period were collected and analyzed; this included patient demographics, referral sources, diagnosis, operation, and length of stay (LOS Conclusion: Emergency workload represents a significant part of the work for the general surgeons. doi = 10.1007/s00068-009-8001-z id = cord-005881-oswgjaxz author = nan title = Abstracts: 11(th) European Congress of Trauma and Emergency Surgery May 15–18, 2010 Brussels, Belgium date = 2010 keywords = Hospital; ICU; ISS; case; complication; conclusion; follow; fracture; group; high; injury; introduction; material; mean; method; patient; result; score; screw; significant; study; surgery; trauma; treatment; year summary = Prospective case series with historical control group.(Level III) Results: Preliminary data indicate: *a shorter time on ventilator than anticipated (based on comparisson to historical data) * a shorter time on ICU * less pneumoniae * no intra-operative complications * good healing results of the rib fractures * no implant failures * acceptable pain scores * good overal satisfaction * acceptable cosmetic results Conclusion: Internal fixation of rib fractures (flair chest or multiple sequential fractures with pulmonary function compromise) results in a earlier recuperation of pulmonary function with shortened ICU stay. (Regional Association Sanitary Emergencies) Material and Methods: The ARES, whose members are about 600, all over the nation, is configured as an extraordinary health resource, activated by the National Civil Defence operations centre, in according with the Regional centre of Marche, in disater situations Results: The main objectives of ARES are training and organization of medical staff and structures and its growth crosses several missions including: AE Earthquake in Molise, 2002 Introduction: Cephalomedullary nails rely on a large lag screw that provides fixation into the femoral head. doi = 10.1007/s00068-010-8888-z id = cord-006182-kck5e1ry author = nan title = 17th Annual Meeting, Neurocritical Care Society, October 15–18, 2019, Vancouver, Canada date = 2019-10-01 keywords = AIS; Care; DCI; EEG; EVD; GCS; ICH; ICP; ICU; IQR; January; LOS; MRI; NCC; NIHSS; SAH; SDH; Scale; TBI; TCD; TTM; TXA; day; outcome; patient; stroke; study summary = The primary objective of COGiTATE (CppOpt GuIded Therapy Assessment of Target Effectiveness) is to demonstrate feasibility of individualising CPP at CPPopt in TBI patients, expressed as the percentage of monitoring time for which CPP is within 5 mmHg of regularly updated CPPopt targets during the first 5 days of Intensive Care Unit (ICU) admission. Neurocritical care has become increasingly subspecialized.Yet, due to limited availability of dedicated Neurocritical Care units (NCCUs), often patients may need to be admitted to ICUs other than NCCUs. This survey based study was conducted to explore self-reported knowledge in recognizing and managing some common neurological emergencies such as stroke, status epilepticus, raised intracranial pressure etc among critical care nurses at a Comprehensive Stroke Center. Coagulation factor Xa (recombinant), inactivated-Xa inhibitor associated life--factor prothrombin complex concentrate (PCC) was utilized offRetrospective, single center, cohort study including adult intracranial hemorrhage patients who received discharge between efficacy (defined by International Society on Thrombosis and Haemostasis criteria), thrombotic events, ICU and hospital length of stay, and mortality. doi = 10.1007/s12028-019-00857-7 id = cord-006226-fn7zlutj author = nan title = Abstracts of the 4th annual meeting of the German Society of Clinical Pharmacology and Therapy: Hannover, 14–17 September 1994 date = 1994 keywords = ASA; HPLC; PGE1; blood; concentration; cost; dose; drug; effect; increase; mmc; patient; result; study; time summary = The following were analysed: heart rate (HR, bpm), pre-ejection time (PEP, ms), ejection time (VET, ms), HR-corrected electromechanical systole (QS2c, ms), impedance-cardiographic estimates of stroke volume (SV, ml), cardiac output (CO, I/min) and peripheral resistance (TPR, dyn.s.cm -5) calculated from CO and mean blood pressure (SBP and DBP according to auscultatory Korotkoff-I and -IV sounds This indicates that 1) about half the rise of HR and CO and half the shortening of PEP is 131-respectively 1~2-determined, 2) that predominant 132-adrenergic responses, whilst not affecting VET, take optimal benefit from the inodilatory enhancement of pump performance, 3) that an additional 131-adrenergic stimulation is proportionally less efficient, as VET is dramatically shortened, thus blunting the gain in SV so that the rise in CO relies substantially on the amplified increase of HR and 4), VET is more sensitive than QS2c in expressing additional 131-adrenoceptor agonism and 5) prime systolic time intervals provide a less speculative and physiologically more meaningful represenation of cardiac pump dynamics than HR-corrected ones. doi = 10.1007/bf00193489 id = cord-006229-7yoilsho author = nan title = Abstracts of the 82(nd) Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) and the 18(th) Annual Meeting of the Network Clinical Pharmacology Germany (VKliPha) in cooperation with the Arbeitsgemeinschaft für Angewandte Humanpharmakologie e.V. (AGAH) date = 2016-02-06 keywords = 3-mcpd; GRK2; Germany; IL-6; LPS; OCT1; PKA; PLN; STW; THP-1; VPA; activation; assay; cell; concentration; different; dna; drug; effect; expression; fret; high; human; increase; level; method; model; mouse; potential; protein; receptor; result; s1p; study; test; treatment; trpc5; western summary = It directly activates Protein Kinase A (PKA) or the Exchange protein directly activated by cAMP (Epac) which is a guanine exchange factor (GEF) for the small monomeric GTPase Rap. As Human umbilical vein endothelial cells (HUVEC) express both cAMP effectors (Epac1 and PKA), we investigated the role of cAMP-signaling using a spheroid based sprouting assay as an in vitro model for angiogenesis. After activation, S1P receptors regulate important processes in the progression of renal diseases, such as mesangial cell migration Methods and Results: Here we demonstrate that dexamethasone treatment lowered S1P 1 mRNA and protein expression levels in rat mesangial cells measured by TaqMan® and Western blot analyses. The aim of this study was to investigate the relevance of IGFBP5 in cardiogenesis and cardiac remodeling and its role as a potential target for ameliorating stress-induced cardiac remodeling Methods and Results: We investigated the expression of Igfbp5 in murine cardiac tissue at different developmental stages by qPCR normalized to Tpt1 (Tumor Protein, Translationally-Controlled 1). doi = 10.1007/s00210-016-1213-y id = cord-006230-xta38e7j author = nan title = Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie e.V. date = 2012-02-22 keywords = ATP; ERK; Germany; IL-6; Institut; LPS; NDPK; PCR; PKA; Pharmakologie; RKIP; ROS; Rac1; TNF; TRPC6; TRPM3; TTC; Toxikologie; Universität; V79; activity; cell; concentration; dna; effect; expression; gene; human; increase; level; mouse; protein; receptor; result; study; western summary = Here, we will present our analysis of Ca 2+ signaling following stimulation of the FcεRI receptor and application of secretagogues that are supposed to affect Ca 2+ -dependent mast cell activation such as adenosine, endothelin-1, substance P and compound 48/80 in BMMCs and PMCs derived from mouse lines with inactivation of TRPC1, TRPC3, TRPC4, TRPC5 or TRPC6 since specific antagonists are still lacking for these TRP channels. These data indicate that increased PP2A activity is associated with modified gene expression in TG hearts possibly affecting stress response and regulation of cell signalling. As demonstrated by qPCR and Western blot experiments, mesangial cells showed a marked time-and dose-dependent upregulation of CSE mRNA and protein levels after treatment with platelet-derived growth factor (PDGF-BB). The transcription factor cAMP response element (CRE)-binding protein (CREB) plays a critical role in regulating gene expression in response to activation of the cAMPdependent signaling pathway, which is implicated in the pathophysiology of heart failure. doi = 10.1007/s00210-012-0736-0 id = cord-006391-esnsa4u5 author = nan title = Abstracts 5(th) Tripartite Meeting Salzburg/Austria, September 9–11,1982 date = 1982 keywords = AMX; ATP; Doppler; Group; animal; blood; cell; control; day; effect; graft; increase; level; liver; method; normal; patient; rat; result; study summary = In our parallel tests using an excision-sample technique [2] which is considerably more sensitive than the DGHM procedure, we have observed the following mean reductions in the counts of accessible bacteria: iodine in ethanol, 96%; povidone-iodine, 89%; chlorhexidine in ethanol, 88%; iso-propanol, The purpose of this study was to compare radiation injury in Guinea Pig small bowel (1) devoid of contents (2) containing bile (3) containing pancreatic juice. Studies in vitro employing isolated perfused rat pancreas and stomach revealed following results: Mean basal pancreatic somatostatin release in normal, diabetic and transplanted rats were 12___3, 24-t-7, and 17__+4 pg/ml, respectively. As these changes appear closely correlated to the blood glucose levels which show a 30 % decrease at 4 h and progressive restoration towards normal values up to 24 h, attempts have been made to alter the insulin/glucagon ratio by glucose infusion after PH and study its relation to liver regeneration. doi = 10.1007/bf01279099 id = cord-006563-qmigctkp author = nan title = The abstracts of the 26th congress of ESCTAIC, Timisoara, Romania, September 22–24 2016 date = 2017-03-07 keywords = Sipnose; block; pain; patient; postoperative; study; surgery; surgical summary = doi = 10.1007/s10877-017-9991-4 id = cord-006702-ekf6mja9 author = nan title = Abstracts for the 17th IPNA Congress, Iguaçu, Brazil, September 2016: Oral Presentations date = 2016-08-17 keywords = CKD; Hospital; Objectives; UTI; University; VUR; child; patient; result; study summary = After correction using the optimal linear regression, the variability of the measurements was examined using Bland-Altman plots Results: We studied 29 patients (17 male, 12 female) with a median age (SD) of 14.0 (3.4) years and eGFR 111 (17) Objectives: Mutations of the Pkhd1 gene cause autosomal recessive polycystic kidney disease (ARPKD). Objectives: To examine the characteristics, follow up and availability of long term outcome data in a cohort of New Zealand children with acute kidney injury (AKI) requiring renal replacement therapy (RRT) following cardiac surgery at Starship Hospital over a six-year period. Methods: Cohort study conducted from 2008-2012 of 57 female patients age 9-21 years recruited from 2 pediatric nephrology clinics with CKD (n=25), on dialysis (n=9), or status post kidney transplantation (n=23) who received the standard 3-dose vaccine series of the HPV vaccine. doi = 10.1007/s00467-016-3466-6 id = cord-006849-vgjz74ts author = nan title = 27th International Congress of the European Association for Endoscopic Surgery (EAES) Sevilla, Spain, 12–15 June 2019 date = 2019-09-13 keywords = BMI; December; ERCP; Endosc; GERD; Hospital; ICG; January; Japan; MRI; Medical; Nissen; November; TME; University; aim; approach; cancer; case; complication; conclusion; day; gastric; group; hernia; laparoscopic; method; patient; perform; postoperative; procedure; resection; result; robotic; roux; study; surgery; surgical; time; treatment; year summary = Methods: We are performing this procedures within a prospective randomized trial that is design to compare the long term results of LRYGB-B versus the standard laparoscopic Roux-en-Y gastric bypass.The video shows our technique in a case of a 46 years old female with a BMI of 46 Kg/m2. Material and methods: We present a video of the surgical intervention of a 32-year-old patient, with functional dyspepsia, with a casual diagnosis of a pseudocystic mass of the right colon after performing a CT scan: giant diverticulum of the hepatic colon angle with fecaloid content inside it under tension The patient goes to the emergency room for acute abdominal pain, pending colonoscopy, antibiotic treatment is established, and a laparoscopic approach is decided upon after the patient''s evolution. Method: We present the case of a 65-year-old patient with surgical antecedent of laparoscopic low anterior resection due to rectal cancer, presenting in postoperative period an anastomosis leakage with severe peritonitis was identified and a laparotomy with end colostomy was performed. doi = 10.1007/s00464-019-07109-x id = cord-006854-o2e5na78 author = nan title = Scientific Session of the 16th World Congress of Endoscopic Surgery, Jointly Hosted by Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) & Canadian Association of General Surgeons (CAGS), Seattle, Washington, USA, 11–14 April 2018: Poster Abstracts date = 2018-04-20 keywords = BMI; CBD; Center; ERCP; FLS; GERD; Hospital; ICG; January; LOS; LSG; Medical; RYGB; SILS; University; case; complication; conclusion; follow; gastric; group; hernia; introduction; laparoscopic; method; operative; outcome; patient; postoperative; procedure; rate; report; result; robotic; roux; study; surgeon; surgery; surgical; time summary = Totally Laparoscopic ALPPS Combined with the Microwave Ablation for a Patient with a Huge HCC Hua Zhang; Department of Hepatopancreatobiliary Surgery, West China Hospital, Sichuan University Introduction: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a novel technique for resecting hepatic tumors that were previously considered unresectable due to the insufficient future liver remnant (FLR) which may result in postoperative liver failure (PLF). Not only does this case show that a large epiphrenic diverticulm can be successfully resected via the trans-abdominal laparoscopic approach, this case makes the argument that patients undergoing any minimally-invasive epiphrenic diverticulectomy and myotomy, with or without fundoplication, may be successfully managed with early post-operative contrast studies and dietary advancement, thus decreasing their length of hospitalization and overall cost of treatment. Introduction: There are reports of increased operative duration, blood loss and postoperative morbidity, caused by difficulties in obtaining good visualization and in controlling bleeding when laparoscopic resection is performed in obese patients with colon cancer. doi = 10.1007/s00464-018-6121-4 id = cord-006860-a3b8hyyr author = nan title = 40th Annual Meeting of the GTH (Gesellschaft für Thrombose- und Hämostaseforschung) date = 1996 keywords = ADP; APC; APTT; DVT; ELISA; FXII; Germany; HUVEC; INR; LMWH; Leiden; PAI; PCR; STA; TEG; VIII; activity; blood; cell; dna; factor; hat; heparin; high; increase; level; patient; plasma; platelet; protein; result; study; time summary = Dept of Pediatrics, University Hospitals Kiel and Mtinster, Germany Resistance to activated protein C (APCR), in the majority of cases associated with the Arg 506 Gin point mutation in the factor V gene is present in more than 50 % of patients < 60 years of age with unexplained thrombophilia. The regular APC resistance test is not applicable to plasma from Orally anticoagulated (OAC) or heparinized patients due to decreased levels of vitamin K-dependent clotting factors and to thrombin inhibition by antithrombin, respectively. On admission an extensive coagulation screen yielded the following results (n/normal, t/elevated, I/reduced, +/positive, -/negative): PT t, aPTT t, Tr n, factor II, V, VIII n, factor VII, IX, XI, XII /,, fibrinogan t, ATIII n, protein C, S *, activated protein C sensitivity ratio 1.92 ($), FV-Leidenmutation PCR -, fibrinolytic system n, TAT t, Ft÷2 t, lupus anticoagulant +, heparin induced platelet antibodies +; no diagnosis of a specific autoimmuna disorder could be made. doi = 10.1007/bf00641048 id = cord-006862-5va1yyit author = nan title = ITS ASM 2012 date = 2012-11-04 keywords = AAT; AATD; COPD; Hospital; IPF; Ireland; OSAS; disease; lung; patient; study; year summary = 10 .45 % (n = 202) of attendances were for non-respiratory diseases as the clinic also provides follow-up for general medical patients post hospital admission. Higher levels of exercise participation were seen in the younger age groups (p = 0.585 Introduction: Respiratory diseases, largely represented by COPD, are the third most common cause of acute hospital admission.Our aim was to audit the prescribing habits of inhaled, nebulised medication and oxygen by doctors in a general hospital. Our study was designed to determine the baseline and post-treatment values of total lymphocyte count and its subsets in HIV-negative patients diagnosed with active pulmonary MTB. The results of this study indicate that AAT can inhibit LTB 4 signaling thereby reducing the proteolytic activity of neutrophils and propose AAT aerosolized augmentation therapy as an effective treatment for LTB 4 associated pulmonary diseases including cystic fibrosis and severe asthma. doi = 10.1007/s11845-012-0856-z id = cord-006870-f5w6fw6q author = nan title = Abstracts Presented at the Neurocritical Care Society (NCS) 15th Annual Meeting date = 2017-09-19 keywords = AED; CSF; Care; DCI; EEG; EVD; GCS; Glasgow; ICH; ICP; ICU; IQR; January; LOS; MAP; MRI; NCCU; NIHSS; SAH; SDH; SRSE; Scale; TBI; VTE; brain; day; high; outcome; patient; stroke; study; time summary = Subjective perceptions of recovery were assessed via responses to the forced-choice dichotomized question, "Do you feel that you have made a complete recovery from the arrest?"Objective outcome measures of recovery included: Repeatable Battery for Neuropsychological Status (RBANS), Modified Lawton Physical Self-Maintenance Scale (L-ADL), Barthel Index (BI), Cerebral Performance Category Scale (CPC), Center for Epidemiological Studies-Depression scale (CES-D), and Post traumatic stress disorder-checklist (PTSD-C). Utilizing data from the Citicoline Brain Injury Treatment (COBRIT) trial, a prospective multicenter study, we identified 224 patients who met the inclusion criteria; 1) placement of an ICP monitoring device, 2) Glasgow coma score (GCS) less than 9, 3) EVD placement prior to arrival or within 6 hours of arrival at the study institution. The objective of this study was to examine the incidence rates of pre-specified medical and neurological ICU complications, and their impact on post-traumatic in-hospital mortality and 12month functional outcomes. doi = 10.1007/s12028-017-0465-9 id = cord-006876-v2m5l5wz author = nan title = Neurocritical Care Society 14(th) Annual Meeting date = 2016-08-11 keywords = CPP; Care; DCI; EEG; GCS; ICH; ICP; ICU; INR; January; MRI; NIHSS; PCC; SAGE-547; SAH; SRSE; TBI; USA; University; brain; day; outcome; patient; study summary = We conducted a prospective cohort study among mild and moderate-severe TBI patients admitted to a level 1 trauma center with these inclusion criteria: 1) Age < 65 years, 2) No severe non-TBI injuries, 3) No prior cardiac disease, and 4) Minimal comorbidities. In most instances, DC has been performed based on neurosurgical evaluation of the patient with or without intracranial pressure (ICP) monitoring and evidence of increased shown variable outcomes in emergency (within 4 hours of injury) neurosurgical procedure in Traumatic Brain Injury (TBI). This is an observational cohort study of adult patients (>18 years) in a 10-bed NSICU at an academic, tertiary care center evaluating quality outcome measures pre-and post-neurointensivists. Intensivists in neuro ICU must consistently assess and treat the non-neurological complications in traumatic brain and spine-injured patients and deliver appropriate care to bring down the mortality and morbidity and improve outcome. doi = 10.1007/s12028-016-0301-7 id = cord-006880-9dgmdtj8 author = nan title = Neurocritical Care Society 10th Annual Meeting: October 4 - 7, 2012 Sheraton Denver Downtown Hotel Denver, Colorado date = 2012-09-19 keywords = CSF; Care; DCI; EEG; GCS; GOS; Glasgow; ICH; ICP; ICU; IQR; IVH; MRI; NIHSS; Neurocritical; SAH; Scale; TBI; TCD; brain; day; outcome; patient; study summary = Patients initially comatose after cardiac arrest treated who awoke after therapeutic hypothermia (TH) were evaluated by a neuropsychologist prior to hospital discharge with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), a well-validated tool that assesses function in multiple domains compared to standardized normal values. Clinical data including the pre-admission-status, neuroradiological, initial presentation, treatment, and outcome were evaluated through institutional databases, patient''s medical charts and by mailed questionnaires. To determine the differences in hospital outcomes among adult mild traumatic brain injury (TBI) patients where the severity of TBI is defined by Glasgow Coma Scale (GCS) score. Retrospective chart analysis was performed on all adult patients arriving to emergency department with history of fall at a level one trauma center for parameters like vomiting, alteration of consciousness (AOC) & loss of consciousness (LOC) after TBI; post-traumatic amnesia (PTA) and history of seizures before or after injury, along with outcomes such as ICU admission & ICU length of stay. doi = 10.1007/s12028-012-9775-0 id = cord-006882-t9w1cdr4 author = nan title = Royal Academy of Medicine in Ireland date = 2012-07-22 keywords = DEXA; Hospital; case; disease; medical; patient; study; year summary = Objective: The aim of this study was to develop a mathematical model to determine the TTO based on two or more DEXA scans with TTO defined as the age at which the patient will enter the osteoporotic T-score range. An Audit of Clinical Outcomes in Transcervical Resection of the Endometrium Compared to Outpatient Balloon Thermablation Anglim BC, Von Bunau G Department of Gynaecology, Adelaide and Meath Children''s Hospital, Tallaght, Dublin Thermablation was introduced to the Coombe in November 2009 and thus far it has provided a quick and effective means of treating women with menorrhagia refractive to medical treatment. This audit reviewed cases of ovarian cystectomy, oopherectomy and salpingooopherectomy using both a hospital online database and records of theatre procedures to identify these patients. A retrospective review of the case notes of patients aged greater than 80 years who underwent bronchoscopy between September 2009 and November 2011 was carried out. doi = 10.1007/s11845-012-0833-6 id = cord-006888-qfnukav4 author = nan title = Irish Thoracic Society Annual Scientific Meeting, Ramada Hotel, Belfast: 7th–8th November 2008 date = 2008-10-21 keywords = A1AT; AAT; COPD; FEV1; Hospital; Ireland; LPS; OSA; Society; TBNA; lung; patient; study summary = 2 This study explored anxiety, depression and QoL of a small group of patients (n = 5), predominantly male (66.7%), mean age 74 years, using the Marie Curie ''''breathing space'''' outpatient clinic over a four week period. Methods: CF patients attending CUH completed a questionnaire relating to personal smoking and second-hand smoke (SHS) exposure, correlated with pulmonary function and exacerbation-rate data. This ongoing study indicates that a clinical pharmacy led management programme can reduce the need for hospital care in patients with moderate-to-severe COPD and improve aspects of their health related quality of life. There is a need for wider availability of joint hospital/ community based initiatives such as COPD Outreach and PRPs. Pulmonary rehabilitation has established efficacy, but patients often require follow-up care or maintenance. Patient data (MDS/ISWT/endurance shuttle walking test(ESWT)) from our pulmonary rehabilitation programme were initially analysed (n = 214; median FEV 1 = 1.04 L; mean age = 69 yrs). doi = 10.1007/s11845-008-0235-y id = cord-007890-bie1veti author = nan title = ECC-4 Abstracts date = 2002-04-16 keywords = Department; Diseases; ESBL; France; HAART; HCV; HIV; Hospital; IFN; Infectious; Institute; MIC; MRSA; Medical; Medicine; Microbiology; NCCLS; PCR; Purpose; RNA; Spain; Staphylococcus; University; gram; isolate; patient; resistance; result; strain; study summary = Effects of Interferon alpha plus ribavirine therapy on frequencies of HCV, HIV and CMV specific CD4-T-cell responses in peripheral blood of HIV/HCV coinfected patients after 6 months of treatment SoA9.5 Methods: Two groups of patients with chronic HCV infection were studied: 26 HIV coinfected progressors with antiretroviral therapy and 13 HIV-negative controls. In order to assess the local temporal trend of antibiotic sensitivity of the most common urinary tract bacterial pathogen, all urine-cultured Escherichia coli isolates were reviewed as to susceptibility profile, and specimen source (community-versus hospital-acquired infection). Methods: A total of 87 penicillin resistant clinical strains isolated from patients at Hacettepe Children''s Hospital, Ankara, Turkey between 1999 and 2001 were tested for their in vitro susceptibility to various antibiotics that are commonly used in the treatment of respiratory tract infections. doi = 10.1016/s0924-8579(02)00033-x id = cord-008777-i2reanan author = nan title = ECB12: 12th European Congess on Biotechnology date = 2005-07-19 keywords = Ankara; Biology; Biotechnology; Chemical; Denmark; Department; Engineering; Escherichia; Faculty; Germany; HPLC; Institute; PCR; Research; Science; Technical; Technology; Turkey; University; acid; activity; analysis; bacillus; cell; concentration; condition; culture; different; dna; effect; enzyme; expression; fermentation; gene; growth; high; increase; medium; method; process; produce; production; protein; result; strain; study; system summary = Mollerup Department of Chemical Engineering, Building 229, DTU, 2800 Lyngby, Denmark A variety of factors that govern the properties of proteins are utilized in the development of chromatographic processes for the recovery of biological products including the binding and release of protons, the non-covalent association with non-polar groups (often hydrophobic interactions), the association of small ions (ion exchange) and the highly specific antigen-antibody interaction (affinity interactions). Such fermenters will be needed in order to meet the increasing pressure on costs for low price commodity type products such as single cell protein or food and technical grade enzymes, and to meet the demands of the new wave of white biotech, in which bio-produced chemicals must be made at prices competitive with those of the traditional chemical industry. The presentation will focus on use of the sensitive sandwich hybridization technology for the quantitative analysis of process relevant marker genes in different kind of microbial cell cultures with a focus on the production of recombinant proteins. doi = 10.1016/j.jbiotec.2005.06.005 id = cord-009571-mygj2nd4 author = nan title = Proceedings of the 42nd annual meeting of the american rheumatism association a section of the arthritis foundation june 1 & 2, 1978 new york city abstracts of papers presented date = 2005-11-23 keywords = HLA; SLE; antibody; cell; disease; dna; normal; nzb; patient; study summary = Levels of Ty cells as well as total T lymphocytes were measured in 19 patients with systemic lupus erythematosus (SLE), 11 with active and 8 with inactive disease, and in 47 normal subjects. The diagnosis of GC arthritis were studied for the presence of GC antigen (AG) and anti-in all seven patients was made by typical clinical presentation, body (AB) in serum and synovial fluid by counter-positive local culture for Ngonorrhoeae (NG) , and response to treatment. A retrospective study was instituted on 10 patients in the UCLA lupus nephritis clinic in an attempt to determine the ability of three serologic indicators-specifically immune complexes (IC), anti-DNA antibodies (DNA-ab), and C3-to predict the activity of SLE renal disease as indicated by changes in 24 hour proteinuria, serum creatinine, and creatinine clearance. doi = 10.1002/art.1780210508 id = cord-009664-kb9fnbgy author = nan title = Oral presentations date = 2014-12-24 keywords = CDI; CTX; Candida; ESBL; Europe; MRSA; PCR; PFGE; PVL; clinical; dna; gene; gram; infection; isolate; method; objective; patient; resistance; result; strain; study summary = Because of the conflicting reports and lack of published data from paediatric patients, we sought to assess possible MIC change over time and to compare results generated by using different methodologies including Etest, agar dilution, and broth microdilution (MicroScan) methods. Recently, in vitro and in vivo studies have shown that NO plays a key role in the eradication of the leishmania parasite Objective: To determine whether a NO donor patch (developed by electrospinning technique) is as effective as meglumine antimoniate in the treatment of CL while causing less adverse events Methods: A double-blind, randomised, placebo-controlled clinical trial was conducted with 178 patients diagnosed with CL in Santander, Colombia, South-America. To follow the development and spread of the resistance among these strains is difficult, as antibiotic susceptibility testing of clinically relevant anaerobes in different routine laboratories in Europe is less and less frequently carried out due to the fact, that clinicians treat many presumed anaerobic infections empirically. doi = 10.1111/j.1469-0691.2009.02857.x id = cord-009713-sxd4t2tz author = nan title = Poster Presentations date = 2020-01-10 keywords = CSF; Children; DMD; EEG; Hospital; MRI; Neurology; Paediatric; age; case; child; conclusion; patient; present; report; result; seizure; study; year summary = Poster No. 010 Seizure, developmental and cognitive outcomes in children post hemispherotomy TT TAY 1 , DR REED 2 , VJ JOSAN 3 , SR RUST 4 , JT TAN 5 1 University of Manchester, Manchester, UK; 2 Neuropsychology Team, Paediatric Psychosocial Service, Royal Manchester Children''s Hospital, Manchester, UK; 3 Neurosurgery, Salford Royal NHS Foundation, Manchester, UK; 4 Paediatric Neuropsychology, Royal Manchester Children''s Hospital, Manchester, UK; 5 Paediatric Neurology, Royal Manchester Children''s Hospital, Manchester, UK Introduction: Patients with focal refractory epilepsy secondary to structural hemispheric changes have been shown in retrospective studies to have significantly improved seizure outcomes following hemispheric disconnection. In a univariate analysis of 682 cases with ≥12 months follow-up data, poor final outcome (defined as modified Rankin Scale [mRS] score 3-6) occurred in 30% and was associated with very young or elderly age at onset, movement disorder, decreased consciousness, autonomic dysfunction, mechanical ventilation, higher mRS score in the acute phase, longer hospital stay, extreme delta brush on EEG, abnormal MRI, CSF pleocytosis and elevated CSF protein (all p<0.05). doi = 10.1111/dmcn.14411 id = cord-009997-oecpqf1j author = nan title = 2018 ASPHO ABSTRACTS date = 2018-03-31 keywords = AKI; AML; AYA; BRAF; Background; CNS; Cancer; Center; Children; EBV; GVHD; Group; HLH; HSCT; Hospital; January; MRD; MRI; Medical; Method; S301; SCD; States; TCD; United; University; VOC; VTE; cell; child; disease; high; patient; pediatric; result; study; therapy; treatment; tumor; year summary = Completed cranial radiation and proceeded to allogeneic stem cell transplant with unrelated cord marrow donor and is disease free at approximately day +200.Case 2: 5 year-old female diagnosed with FLT3 and MLL negative AML and completed treatment per COG AAML1031 study on the low risk arm without Bortezomib. Design/Method: This study was a retrospective chart review that included patients 3 to 23 years old with sickle cell disease type SS and S 0 followed at St. Christopher''s Hospital for Children. Background: Hydroxyurea, chronic blood transfusion, and bone marrow transplantation can reduce complications, and improve survival in sickle cell disease (SCD), but are associated with a significant decisional dilemma because of the inherent risk-benefit tradeoffs, and the lack of comparative studies. Brown University -Hasbro Children''s Hospital, Providence, Rhode Island, United States Background: Despite clinical advances in the treatment of sickle cell disease (SCD) in pediatric and young adult patients, pain remains a significant source of disease-related morbidity. doi = 10.1002/pbc.27057 id = cord-010027-r0tl01kq author = nan title = Dublin Pathology 2015. 8th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland date = 2015-09-15 keywords = EQA; FFPE; Hospital; IHC; Ireland; NGS; PCR; University; cancer; case; cell; diagnosis; dna; expression; patient; result; study; tumour summary = doi = 10.1002/path.4631 id = cord-010075-72jodunj author = nan title = Paediatric SIG: Poster Session date = 2011-03-21 keywords = ASM; COPD; FEV; HRV; Interest; Nil; airway; cell; increase; method; patient; result; study summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. doi = 10.1111/j.1440-1843.2011.01937_12.x id = cord-010092-uftc8inx author = nan title = Abstract of 29th Regional Congress of the ISBT date = 2019-06-07 keywords = ABO; AIHA; Alinity; Background; Blood; CD34; Conclusions; DAT; December; HBV; HCV; HDFN; HEV; HIV; HLA; Health; Hospital; January; NAT; National; PBM; PCR; PLT; RBC; RHD; RNA; Red; SCD; Service; Summary; Transfusion; aim; anti; cell; dna; donation; donor; group; method; patient; platelet; result; sample; study; test summary = Prospective testing of blood donations in endemic areas of the U.S. revealed 0.38% of donors were positive for Babesia DNA or antibodies (Moritz, NEJM, 2016) Aims: -To report results of ongoing Babesia clinical trial -To explain significance of Babesia as a TT infection Methods: In cobas â Babesia for use on the cobas â 6800/8800 Systems, is a qualitative polymerase chain reaction nucleic acid amplification test, developed to detect in whole blood (WB) donor samples the 4 Babesia species that cause human disease: B. In sensitivity analyses, there were two discrepant results for HIV testing, three for HCV, and five for anti-HBc. Summary/Conclusions: Elecsys â infectious disease parameters on the cobas e 801 analyser demonstrate high specificity/sensitivity for screening first-time blood donor samples, with similar clinical performance to other commercially available assays. doi = 10.1111/vox.12792 id = cord-010119-t1x9gknd author = nan title = Abstract Presentations from the AABB Annual Meeting San Diego, CA ctober 7‐10, 2017 date = 2017-09-04 keywords = ABO; Anti; Background; Blood; CD36; Case; Center; DAT; DTT; Design; FDA; FFP; HBV; HCV; HIV; HLA; Hospital; IPC; MTP; Medical; Medicine; NAT; PCR; PLT; RBC; RHD; Red; Studies; Study; System; TPE; University; WBC; ZIKV; Zika; cd341; cell; conclusion; day; dna; donor; finding; method; patient; platelet; result; sample; table; test; transfusion; type summary = Conclusion: The wide distribution in the concentration of bioactive lipids among 405 stored RBC units suggests that lipid degradation is highly donor-Background/Case Studies: To ensure availability of biological products to hospitals, blood banks have developed and validated multiple storage conditions for each of their products to maximize shelf life and quality. 1 The Department of Blood Transfusion, The PLA General Hospital, 2 The Department of Blood Transfusion, Air Force General Hospital, PLA Background/Case Studies: Recently, multi researches have reported that longer term-stored red blood cells(RBCs) units were associated with increased risks of clinically adverse events, especially in critically ill patients. Weak D types 1, 2 and 3 express all the major RhD epitopes and these patients can be managed as RhD-positive, which may lead to a reduction in unnecessary Rh immunoglobulin (RhIG) administration and conservation of RhD-negative RBCs. Study Design/Method: RHD genotyping was performed on all patient samples with weaker than expected or discrepant RhD typing results, utilizing a commercially available genotyping kit manufactured by Immucor (RHD BeadChip). doi = 10.1111/trf.14286 id = cord-010980-sizuef1v author = nan title = ECTES Abstracts 2020 date = 2020-05-11 keywords = AIS; Department; Emergency; Fig; GCS; Hospital; ICU; ISS; January; Japan; MCI; Progressions; REBOA; TBI; Trauma; University; case; clinical; conclusion; fracture; group; injury; introduction; material; method; mortality; patient; result; retrospective; score; study; surgery; treatment; year summary = We hypothesized that presentation to a PTC would yield increased mortality when subspecialty intervention was required and that this would be most pronounced at night when in-house attending coverage is absent at all state PTCs. Materials and methods: A review of the Pennsylvania Trauma Outcome Study (PTOS) database was performed to capture patients aged 12-18 who underwent any non-orthopedic trauma surgery. Traumatic subaxial cervical fractures: functional prognostic factors and survival analysis Introduction: The main goal of this study is to identify the risk factors for poor functional outcomes and to analyze the overall survival (OS) and complications rate in patients with traumatic cervical spinal cord injury (SCI) and subaxial cervical fracture (SACF) treated with open surgical fixation. After applying a multiple imputation on all the study variables, a logistic regression generalized estimating equation after adjustment for age, sex, mechanism of trauma, and the injury severity score as covariates and hospitals as a cluster assessed an association between quartile of patient volume in intensive care unit and hospital mortality. doi = 10.1007/s00068-020-01343-y id = cord-011062-ukz4hnmy author = nan title = Poster date = 2020-03-11 keywords = BMI; Center; DXA; Department; Fried; Geriatric; Group; Health; Hospital; Index; Japan; MNA; SPPB; Sarcopenia; University; adult; age; background; frailty; low; method; muscle; objective; old; patient; physical; result; study; year summary = Ming-Yueh Chou 1,3 , Ying-Hsin Hsu 1 , Yu-Chun Wang 1 , Chih-Kuang Liang 1,3 , Li-Ning Peng 2,4 , Liang-Kung Chen 2,4 , Yu-Te Lin 1 ((1) Center for Geriatrics and Gerontology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; (2) Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan; (3) Department of Geriatric Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan; (4) Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan) Background: Older people with frailty are at risk of adverse outcomes, such as falls, functional decline and mortality, and multi-domain intervention program may prevent those. Conclusion: Our study showed that a multicomponent exercise program is effective for posthospitalization patients because after 24-week intervention there were significant reductions in frailty and improving results in muscle strength and physical performance. Methods: Cross-sectional analysis of 757 communitydwelling older adults who completed multi-domain geriatric screen assessing for social vulnerability, mood, cognition, functional performance, nutrition, physical frailty (FRAIL) and sarcopenia (SARC-F). doi = 10.14283/jfa.2020.9 id = cord-012518-ncrdwtdg author = nan title = Abstractband DOG 2020 date = 2020-08-24 keywords = CNV; Germany; Gruppe; IOD; IOP; OCT; Patienten; der; eye; group; patient; result; study summary = The improvement in tear film quality (measured by TBUT) was shown after application of trehalose/hyaluronate tear substitute for one month in both, glaucoma and control group patients with mild to moderate dry eye symptoms. Methods: For 351 eyes (275 patients) who underwent DMEK for Fuchs endothelial corneal dystrophy (FECD), donor ECD decrease as compared to preoperative donor ECD was evaluated up to four years after surgery. The present study included fundus images of 111 individuals with a mean refractive error of -9.3 ± 3.8 diopters (range:-20.8, +1.75) and an axial length of 26.8 ± 1.9 mm (range: 22.55, 30.88) Results: The disc-fovea distance increased significantly with longer axial length, with a relatively flat slope in the non-highly myopic eyes (Disc-Fovea-Distance = 24.3 × Axial Length (mm)+514) and a steeper slope in the highly myopic group (Disc-Fovea-Distance = 58.7 × Axial Length (mm)-460). doi = 10.1007/s00347-020-01197-0 id = cord-014462-11ggaqf1 author = nan title = Abstracts of the Papers Presented in the XIX National Conference of Indian Virological Society, “Recent Trends in Viral Disease Problems and Management”, on 18–20 March, 2010, at S.V. University, Tirupati, Andhra Pradesh date = 2011-04-21 keywords = BTV; CMV; CTV; ELISA; India; PCR; Pradesh; RNA; RTBV; disease; dna; gene; isolate; plant; protein; sequence; study; vaccine; virus summary = Molecular diagnosis based on reverse transcription (RT)-PCR s.a. one step or nested PCR, nucleic acid sequence based amplification (NASBA), or real time RT-PCR, has gradually replaced the virus isolation method as the new standard for the detection of dengue virus in acute phase serum samples. Non-genetic methods of management of these diseases include quarantine measures, eradication of infected plants and weed hosts, crop rotation, use of certified virus-free seed or planting stock and use of pesticides to control insect vector populations implicated in transmission of viruses. The results of this study indicate that NS1 antigen based ELISA test can be an useful tool to detect the dengue virus infection in patients during the early acute phase of disease since appearance of IgM antibodies usually occur after fifth day of the infection. The studies showed high level of expression in case of constructed vector as compared to infected virus for the specific protein. doi = 10.1007/s13337-011-0027-2 id = cord-014516-r59usk02 author = nan title = Research Communications of the 24th ECVIM‐CA Congress date = 2015-01-10 keywords = Animal; CHF; CRP; FCV; IBD; Ltd; PCR; SBP; University; cat; concentration; disease; dog; group; study summary = Serum prolactin concentration measured in 22/23 dogs at time zero, 6 weeks and 6 months was 3.35 ng/ml (range, 1.4-6.36), 3.57 ng/ml (range, 1.87-7.39) and 3.92 ng/ml (range, 2.01-12.92) and did not differ significantly in either time period when compared with time zero (P = 0.99 and P = 0.52).Altogether, results of this study failed to demonstrate a significant role of thyroid supplementation on the majority of evaluated behavioural symptoms as well as neurohormonal status of hypothyroid dogs during 6 months of therapy. The aims of the present study were (1) to describe a clinical series of recent autochtonous cases and (2) to retrospectively assess Angiostrongylus vasorum qPCR in bronchoalveolar lavage fluid (BALF) samples, collected over the last 7 years from a larger series of dogs, healthy or with other respiratory conditions, in order to investigate the past prevalence of the disease in Belgium. doi = 10.1111/jvim.12491 id = cord-014527-nvzfpntu author = nan title = Research Communications of the 25th ECVIM‐CA Congress date = 2015-11-09 keywords = BCS; CHF; CIPF; CKD; FIP; HCM; IBD; PCR; Staphylococcus; University; VEGF; Veterinary; cat; disclosure; dog; group; study summary = A negative outcome was associated with higher fecal S100A12 concentrations in CE dogs, but the response to different forms of treatment and fecal S100A12 has not been reported, and this information will be important to further evaluate the utility of fecal S100A12 as a biomarker for gastrointestinal disease. Statistical analysis was performed using non-parametric 2-or multiple-group comparisons, the likelihood ratio to evaluate the association between groups of dogs and response to treatment, and a receiver operating characteristic curve to calculate sensitivity and specificity at the optimum cut-off concentration. The objectives of this study were to describe pulmonary transit time and myocardial perfusion normalized to heart rate (nPTT and nMP, respectively), evaluated by means of contrast echocardiography, in dogs with stable stage C ACVIM myxomatous mitral valve disease (MMVD), and to assess short-term effects of pimobendan on these parameters. doi = 10.1111/jvim.13647 id = cord-014670-e31g8lns author = nan title = Poster Sessions 313-503 date = 2004-10-05 keywords = APACHE; Care; Hospital; ICP; ICU; Intensive; Unit; University; conclusion; group; patient; study summary = Over a 12-month period patients who needed reintubation after successful trial of weaning and planned extubation, in a polyvalent intensive care unit (ICU) were identified.Data including clinical features (age, sex, SAPS II on admission, Glasgow Coma Score (GCS) on day of extubation, type of patient, length of intubation and mechanical ventilation (MV) before extubation, length of ICU stay (LOS), ICU and hospital mortality) were collected.Moreover we considered two parameters that asses airway patency and protection like predictors of EF:cough strength and suctioning frequency after extubation.Cough strength on command was measured with a semiobjective scale of 0 to 5 (0= weak cough, 5= strong cough). (3/23)(13.2%), pulmonary embolism(1/23)(4.3%)and severe sepsis(1/23)(4.3%).Seven of patients who received reintubation a cause of defective airway manage needed at least one suctioning every two hours; moreover the same patients and other three with alteration in neurological function had weak cough (grade 0 to 2).The LOS of EF patients was 23±24.3 days, their ICU and hospital mortality were 39.1% and 47.8%, respectively, both higher when compared with not reintubated patients.Results of logistic regression showed that SAPS II is the only independent risk-factor of reintubation (odds ratio 1.056, sig. doi = 10.1007/s00134-004-2406-2 id = cord-014685-ihh30q6f author = nan title = Posters P788 - P999 date = 2005-09-21 keywords = Department; France; Institute; Japan; RNA; University; cell; dna; membrane; protein; structure; study summary = doi = 10.1007/s00249-005-0504-x id = cord-014687-0am4l5ms author = nan title = SPR 2012 date = 2012-03-29 keywords = ACR; ADC; Administration; Case; Center; Children; College; DWI; Dr.; Drug; FDA; Food; Hospital; Imaging; MDCT; MRI; Materials; Medical; NF1; PET; Pediatric; Purpose; Radiology; Report; SPR; Society; University; child; clinical; conclusion; diagnosis; finding; image; patient; result; review; study summary = This presentation will focus on recent developments that have lead to a better understanding of the embryopathogenesis for fibropolycystic liver diseases (including choledochal cysts and Caroli disease), histopathological findings that have led to new classification systems for of pediatric vascular anomalies, technological advances and contrast agents in magnetic resonance imaging that are useful to characterize and limit the differential diagnosis of hepatic masses. Disclosure: Dr. Annapragada has indicated that he is a stock holder and consultant for Marval Biosciences Inc. Paper #: PA-067 Cardiovascular Image Quality Using a Nanoparticle CT Contrast Agent: Preliminary Studies in a Pig Model Rajesh Krishnamurthy, Radiology, Texas Children''s Hospital, rxkrishn@texaschildrens.org; Ketan Ghaghada, Prakash Masand, Abhay Divekar, Eric Hoffman, Ananth Annapragada Purpose or Case Report: Image quality in a separate study using a long circulating, liposomal-based nanoscale blood pool iodinated contrast agent (NCTX) suggests clinical utility in pediatrics, potentially reducing difficulties in contrast-CT of children with congenital heart disease (CHD) including the size of intravenous cannula, need for accurate timing, inability to simultaneously opacify multiple targets of interest (requiring repeated contrast administration and/or repeated imaging). doi = 10.1007/s00247-012-2356-8 id = cord-014794-yppi30a0 author = nan title = 19th European Congress of Pathology, Ljubljana, Slovenia, September 6-11, 2003 date = 2003-07-31 keywords = Bcl-2; CD10; CD30; Department; FNA; HCC; Hospital; IHC; III; Institute; Introduction; Ki-67; Ki67; Medical; Medicine; NHL; PCNA; PCR; Pathology; University; VEGF; aim; cancer; carcinoma; case; cell; conclusion; diagnosis; dna; expression; group; high; hpv; lesion; material; method; patient; positive; result; study; tissue; tumor summary = These parts were in a high percentage associated with fibrosis and lymphocyte rich areas and showed a higher mitotic activity than usual PTCs. Discussion The differences in the occurrence of TCV and TCmorphology between the presented series and previously reported cases might result from until now not clearly defined tall cell morphology as well as from similarities to PTCs, such as the oxyphilic variant, which is extremely rare in our series, and maybe also from often described squamous changes within PTCs. Due to these data it is not clear which tumor parts have relevance for prognosis and which tumors should be treated more aggressively than others. The aims of this study were to characterize the group of patients with BSOT and evaluate the significance of various molecular markers expression versus serous papillary ovarian carcinomas (SPOC) Material and methods We analyzed a total of 102 cases including: 64 cystadenoma, 10 borderline and 28 cystadenocarcinoma. doi = 10.1007/s00428-003-0864-5 id = cord-014987-nycbjqn6 author = nan title = OP 0364-0412 date = 2006-08-24 keywords = Care; ICU; VAP; patient; study summary = In the "Prevalence of severe sepsis and septic shock in Intensive Care Units in Germany" study, a prospective observational cross-sectional study, data from 454 ICUs in 310 randomly selected hospitals in Germany were collected by local one-day visits of trained physicians from SepNet''s 17 regional study centers. Despite the higher APACHE II score in both groups (median score 21 or 18.5, respectively compared with 16.5 in the enteral group, p<0.01) our results indicate that parenteral nutrition has an important attributable effect on mortality in septic patients. In this follow up study, we document the impact of intensive insulin therapy on long term mortality and objective and subjective well-being of high risk cardiac surgical patients. 4 years after ICU-admission, we assessed long term outcome of the subgroup of cardiac surgical patients (N=970) included in the original insulin trial (1) . doi = 10.1007/s00134-006-0318-z id = cord-014996-p6q0f37c author = nan title = Posters_Monday_12 October 2009 date = 2009-08-06 keywords = AKI; ALI; APACHE; Care; Hospital; ICU; LPS; PCT; SAPS; VAP; conclusion; group; introduction; method; mortality; objectives; patient; result; sepsis; sofa; study summary = Data recorded on admission were the patient demographics with, acute physiology and chronic health evaluation II score (APACHE II), and type of admission; during intensive care stay, sepsis-related organ failure assessment score (SOFA) and clinical concomitant factors and conditions. For each severe septic patient the following data was registered: time delay, APACHE II and SOFA scores at ICU admission, diagnosis, the rate of compliance with the resucitation and management bundles, microbiological data, evolution of levels of serum lactate, empiric antibiotic therapy, length of stay and mortality in ICU. Sepsis and septic shock remain the most important causes of acute kidney injury (AKI) in critically ill patients and account for more than 50% of cases of acute renal failure (ARF) in intensive care units (ICU). There were no significant differences between the demographic data (sex, age) or the data on admission to intensive care (APACHE II score, ratio of medical to surgical patients) and duration of mechanical ventilation between the two groups. doi = 10.1007/s00134-009-1593-2 id = cord-015021-pol2qm74 author = nan title = Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date = 1994 keywords = APACHE; ARDS; CD14; CD4; CLP; CRP; CSF; ELISA; ICU; IFN; III; IL-1; IL-2; IL-4; IL-6; IL-8; LEH; LPS; MOF; PAF; PMN; SIRS; TNF; University; animal; blood; cell; control; cytokine; day; effect; endotoxin; factor; follow; group; high; increase; injury; level; method; mouse; patient; production; rat; release; response; result; sepsis; septic; shock; study; trauma summary = It is our current understanding that LPS is responsible for many of the pathophysiological events observed during gramnegative infections and that one of the major mechanisms leading to shock and death is the LPS-induced activation of macrophages resulting in the production and release of lipid and peptide mediators, among which tumor necrosis factor seems to be the most important. However plasma IL-6 estimation revealed a statistically significant reduction at 6 hours in tanrine-treated animals compared to glycino and TW controls ( Objective: To evaluate the effects of allogeneic blood transfusion, thermal injury and bacterial garage on interteukin 4 (IL-4), tumor necrosis factor alpha (TNF) production and host mortality and to study if the administration of thymopentth (THY) could affect these events. doi = 10.1007/bf02258437 id = cord-015024-2xzc0uc5 author = nan title = ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date = 2010-08-31 keywords = APACHE; ARDS; CVP; Care; ECMO; Hospital; ICU; Intensive; conclusion; day; group; high; increase; introduction; level; method; objectives; patient; result; sepsis; sofa; study summary = We performed a prospective clinical study in a 17-bed multidisciplinary intensive care unit, including 21 patients with controlled mechanical ventilation and monitored with the Vigileo Ò monitor, for whom the decision to give fluids was taken due to the presence of circulatory, including arterial hypotension (MAP B 65 mmHg or systolic arterial pressure \90 mmHg), and preserved preload-responsiveness condition, defined as SVV C10%. The aim of this study was to compare and evaluate four severity scoring systems in intensive care unit (ICU), including APACHE II, APACHE III, SASP II and MODS in severe septic patient. A prospective observational study was performed in 16 mechanically ventilated critically ill patients (12 M, age 49 ± 17 yr, BMI 25 ± 5 kg/m 2 , ICU admission day 5 ± 3, APACHE II on study 20 ± 7; mean ± SD) and 6 healthy subjects (3 M, age 24 ± 9 year, BMI 24 ± 45 kg/m 2 ). doi = 10.1007/s00134-010-2001-7 id = cord-015082-l629n8is author = nan title = Poster Sessions 323-461 date = 2002-08-29 keywords = ICU; IL-10; LPS; conclusion; group; increase; level; method; mortality; patient; result; sepsis; study summary = 14 patients awaiting urgent cardiac surgical re-vascularisation were studied with measurement of: spirometry; percentage increase in transfer factor from sitting to lying position (TF) as an indicator of micro-vascular lung disease; overnight oximetry on air; and 24hour holter monitoring Patients, who were reintubated on decreased indices of arterial oxygenation under MOSF progressing died in 100% cases ( NIMV is effective method in complex therapy of ARF, developing in postoperative period after cardiac surgery, that leads to significant improvement of lungs biomechanics and gases change function. In a prospective observational study we performed bedside ptO2 measurements in 8 patients with sepsis/septic shock to gain insight in ptO2 values and their dynamic changes related to the course of the illness, as well as investigating the practical applicability of tissue oxygen measurement in the ICU setting. doi = 10.1007/s00134-002-1455-7 id = cord-015090-n6f4xupw author = nan title = PS 339-563 date = 2005-09-10 keywords = Care; Hospital; ICP; ICU; Intensive; PCT; University; conclusion; day; level; method; patient; study summary = We designed this study to examine the effects of fiberoptic bronchoscopy (FOB) with and without BAL on body temperature, systemic arterial pressure, heart rate and supportive therapies requirements in mechanically ventilated patients. Clinical characteristics (Glasgow scale, heart rate, systolic blood pressure), cardiac enzymes (troponin I, total serum creatine kinase and myocardial isoenzyme, myoglobin), ECG changes (ST-T changes, prolonged QT and corrected QT intervals), echocardiographic assessment of cardiac function (left ventricular ejection fraction, hypokinesia) were studied on the day of the admission. It is a prospective study performed during 12 months of the patients with brain trauma admitted in a 24-beds medical-surgical ICU of a 650-beds university hospital. This prospective observational study included 200 adult patients admitted to a 31-bed university hospital medical-surgical ICU during a 3-month period. doi = 10.1007/s00134-005-2780-4 id = cord-015126-cyhcbk1j author = nan title = PS 0036-0344 date = 2007-08-25 keywords = APACHE; ARDS; Care; HFOV; Hospital; ICU; Intensive; PCT; VAP; blood; conclusion; day; group; increase; introduction; method; mortality; patient; peep; pressure; result; sofa; study summary = We compared them with ≥70 years old and an ICU stay < 30 days patients, the differences in ICU mortality, Apache II, age, gender and the necessity for renal replacement therapy (RRT) were not significant (see table) . The patients with mild form of acute pancreatitis had low mortality rate (similar to general ward population) despite positive ICU admission criteria in our case series with fifty per cent development of severe form with organ dysfunction/failure later on. Collected data:Demographics,Management prior and during ICU hospitalization (sedation, catecolamin drug use, blood product transfusion, intra-cranial pressure monitoring, neurosurgical emergency surgery etc.),CT-Scan results, Daily worst Glasgow coma scale, admission Simplified Acute Physiology Score II. This prospective interventional study performed in a surgical Intensive Care Unit of a tertiary University Hospital included 35 (21 males) mechanically ventilated and sedated patients with acute cardiovascular failure requiring cardiac output measurement (transpulmonary thermodilution technique)and a fluid challenge. doi = 10.1007/s00134-007-0820-y id = cord-015147-h0o0yqv8 author = nan title = Oral Communications and Posters date = 2014-09-12 keywords = CIA; COX-2; Department; ELISA; IFN; IL-6; Institute; LPS; MIF; MPO; PAF; PCR; PGE2; TNF; University; cell; disease; effect; expression; increase; inflammation; inflammatory; level; model; mouse; response; result; study summary = Cyclooxygenases (COX) catalyze the first step in the synthesis of prostaglandins (PG) from arachidonic acid.COX-1 is constitutively expressed.The COX-2 gene is an immediate early-response gene that is induced by variety of mitogenic and inflammatory stimuli.Levels of COX-2 are increased in both inflamed and malignant tissues.In inflamed tissues, there is both pharmacological and genetic evidence that targeting COX-2 can either improve (e.g., osteoarthritis) or exacerbate symptoms (e.g., inflammatory bowel disease).Multiple lines of evidence suggest that COX-2 plays a significant role in carcinogenesis.The most specific data that support a cause-and effect relationship between COX-2 and tumorigenesis come from genetic studies.Overexpression of COX-2 has been observed to drive tumor formation whereas COX-2 deficiency protects against several tumor types.Selective COX-2 inhibitors protect against the formation and growth of experimental tumors.Moreover, selective COX-2 inhibitors are active in preventing colorectal adenomas in humans.Increased amounts of COX-2-derived PGE2 are found in both inflamed and neoplastic tissues.The fact that PGE2 can stimulate cell proliferation, inhibit apoptosis and induce angiogenesis fits with evidence that induction of COX-2 contributes to both wound healing and tumor growth.Taken together, it seems likely that COX-2 induction contributes to wound healing in response to injury but reduces the threshold for carcinogenesis. doi = 10.1007/bf03353884 id = cord-015306-us58wwmp author = nan title = Abstracts for the IPNA Congress, 30 August - 3 September 2013, Shanghai, China date = 2013-06-21 keywords = AKI; CKD; DMSA; EBV; ESRD; HSP; HSPN; Hospital; NGAL; Nephrology; Objective; RSV; UTI; University; VUR; child; conclusion; group; kidney; level; method; patient; renal; result; study; year summary = The incidence of renal involvement varies from 20 to 60% and there have been some reports showing that nephritis might be related to an older age at onset, persistent purpura (> 1 month), severe abdominal pain, and relapsing disease.Recently, several studies have shown that galactose-deficient IgA1 (Gd-IgA1) is recognized by anti-glycan antibodies, resulting in the formation of the circulating immune complexes and their mesangial deposition causing renal injury in HSP nephritis and serum galactose-deficient IgA1 levels were highly inherited in children with HSP nephritis.Regarding the treatment of HSP, one randomized double-blinded controlled study recently showed that patients with abdiminal pain or arthralgia may benefit from early treatment with prednisone, but the drug has not been proven to be capable of preventing the development of renal symptoms. doi = 10.1007/s00467-013-2518-4 id = cord-015324-y44sfr0c author = nan title = Scientific Programme date = 2007-09-01 keywords = BMI; CKD; CRF; CRP; Children; DMSA; Department; ESRD; FSGS; GFR; Group; HIV; HSP; HUS; Hospital; III; MMF; Nephrology; PCR; PTH; Pediatric; SDS; SLE; SRNS; TGF; UTI; University; VUR; age; child; conclusion; disease; kidney; method; patient; renal; result; study; year summary = In order to further validate this approach, we performed a prospective randomized open-label multicenter trial in 41 low-risk pediatric renal transplant recipients (12 f, 29 m; mean age 10.1 yrs; range, 3.4 to 17.8) on CsA (target trough level 100-200 ng/ml), MMF (1200 mg/m 2 per day) and methylprednisolone (3) (4) mg/m 2 per day), who were randomly assigned >1 year posttransplant to continue steroids or to withdraw over a period of 3 months. We evaluated MMF in 15 children with LN, 11 F/4 M, mean age: 12.4±3.9 yrs, proteinuria >3 g/day, decreased C3 and increased anti-dsDNA serum levels, normal renal function. Patients and methods: 91 children and adolescents (60 male, 31 female, mean age at transplantation 9.7±5.2 years) with stable renal function and observation period exceeding 6 months were included. doi = 10.1007/s00467-007-0558-3 id = cord-015334-8p124rwp author = nan title = ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts date = 2008-06-11 keywords = Background; DRP; France; Hospital; Objective; Pharmacy; University; care; clinical; conclusion; drug; main; measure; outcome; patient; pharmacist; prescription; result; study; treatment summary = Based on the results of the pharmacoeconomic analysis, development of clinical pharmacy and CIVAS for some drugs will be discussed with the paediatric department Background and Objective: Studies show that up to 38% of patients starting treatment with antidepressants fill only a single prescription at the pharmacy, apparently not accepting treatment. Main Outcome Measures: Data collected were: nurses'' profile (age, length of service, competencies'' self-assessment), knowledge on drugs prescribed to their patients (usage, administration, side-effects, drug interactions…), use of existing tools (i.e. drugs database) and possible tools to be developed by the pharmacy ward to help them in their daily practice. The objectives were:(1)To identify the most relevant minor ailments, agreeing on the specific criteria for referral to the GP.(2)To select the non-prescription drugs, with evidence of safety and effectiveness, for the treatment of the identified minor ailments Design: Qualitative study with an expert panel which was made up of 2 primary care physician from SEMFYC and six community pharmacists (two members of SEFAC and four members of GIAF-UGR). doi = 10.1007/s11096-008-9226-3 id = cord-015335-l0kjxhd1 author = nan title = Irish Society of Gastroenterology: Proceedings for summer meeting – 26th/27th May 1995 in Galway date = 1995 keywords = OLT; disease; patient; study summary = The results suggest that an aneuploid DNA pattern is a predictor of high risk potential for metastases to the liver and may be a useful tool in the "followup" of patients with gastric carcinoma in detecting those at high risk of developing metastases following surgical resection. A partially purified preparation of oesophageal tumour-derived inimune suppressor factor that has been shown to be free of all known cytokines was tested in dose-ranging studies on cell proliferation and apoptosis using lymphocytes from the mutant and control mice. Currie et al have demonstrated that arginase is cytotoxic to tumour cells by depletion of the essential amino acid L-arginine, therefore the aim of this study was to determine the role of this enzyme in colorectal tumour-derived MOs. Human peripheral blood monocytes (PBM) were isolated from aged-matched controls (CON) and from blood pre-operatively obtained from patients undergoing surgery for colorectal cancer. doi = 10.1007/bf02967835 id = cord-015348-qt0worsl author = nan title = Abstract date = 2010-07-30 keywords = Dept; EGFR; Hospital; IHC; MGMT; Objective; PCR; Pathology; University; VEGF; cancer; carcinoma; case; cell; conclusion; diagnosis; disease; dna; expression; kit; lesion; method; patient; result; study; tissue; tumor summary = However, the application of the compounds in clinical trials has revealed promising results only when predictive procedures have been available for determining which patients will benefit from targeting therapy, so-called eligibility or predictive tests, e.g. Her2 in breast cancer, KRAS and EGFR mutations in colorectal cancer and non-small cell lung cancer. Conclusion: We report on the development of a quantitative tissue-based immunohistochemical (IHC) methodology employing activation-specific antibodies against multiple components of the BCR signaling pathway that will assess the activity of the BCR pathway in formalin-fixed paraffinembedded primary DLBCLs. This approach will identify the subset of patient tumors that are actively signaling through the BCR pathway and, therefore, will predict therapeutic responsiveness to targeted inhibition of BCR signaling. Method: In our study, we investigate 120 cases diagnosed with invasive breast carcinoma in which we established microscopic characterization, immunohistochemical profiles (expression of proliferation markers, steroid receptors and Her2) and computer-assisted morphometric profiles by determining the mean values for nuclear area, cellular area and N/C ratio with Lucia Net Software. doi = 10.1007/s00428-010-0947-z id = cord-015352-2d02eq3y author = nan title = ESPR 2017 date = 2017-04-26 keywords = ADC; CNS; CXR; DWI; JIA; LUS; MRE; MRI; Objective; Pediatr; Radiol; Suppl; ZIKV; case; child; diagnosis; disease; figure; finding; high; image; imaging; patient; pediatric; study summary = Lapierre; Montreal/CA Summary: Objectives: To review the classification of visceroatrial situs To describe the associated cardiac and non-cardiac anomalies To illustrate typical findings in fetuses, neonates and children To discuss the surgical consideration and the long-term follow-up in these patients Abstract: By definition, the type of situs is determined by the relationship between the atria and the adjacent organs. As is often the case, radiology in JIA is all about: knowing your clinicians (i.e. the pretest likelihood for disease) being technically eloquent (e.g. using high-resolution US probes, not delaying post-contrast MRI acquisitions) knowing what is normal (e.g. normal undulations in the articular surface, focal bone marrow signal variation) not being dogmatic about individual observations or measurements interpreting your findings in a clinical context The lecture will demonstrate similarities and differences among joints and modalities in children with variable-severity JIA. doi = 10.1007/s00247-017-3820-2 id = cord-015354-yknwveyz author = nan title = Abstracts_Poster presentations date = 2007-09-18 keywords = 18F; CAD; DMSA; DOTA; DTPA; FBP; FDG; GFR; Group; HMPAO; Hospital; LVEF; MIBG; MIBI; MPS; MRI; Medicine; Nuclear; PET; ROI; SLN; SPECT; SUV; Siemens; Tc-99; University; WBS; aim; conclusion; high; i-123; i-131; image; mean; method; patient; result; scan; study; uptake summary = Material and Methods: Fourteen individuals (mean age 47±19y range 21-75y; 4W, 10M; including 10 volunteers and 4 patients with angiographically proved CAD) underwent dynamic PET imaging studies (21 frames) at rest and during adenosine stress (0.14mg/kg/min for 6 min) after injection of 1100MBq of 82Rb (Discovery LS, GEMS). Methods:Twenty-nine patients (21 males,8 females;62±11 yrs) with recent AMI were studied.Within 6 days after AMI, the patients were performed Tl-201 R-RD perfusion SPECT using 4 mCi activity.CMR was carried out 5-20 minutes after 0,15 mmol/kg of iv.Gadobutrol injection.Myocardial perfusion and contrast enhancement was analyzed using a 17 segment model.Myocardial perfusion was scored in Tl-201 SPECT as follows:0=normal (70%-100% maximal myocardial activity(mma), 1= 69-50% mma, 2= 49-30% mma ,3=29-10% mma and 4=<10% mma ;Myocardial contrast enhancement on CMR images was graded as:0=no contrast enhancement, 1=hyperenhancement of 0-25% of the wall thickness(WT) 2=hyperenhancement of 26-50 % of the WT, 3=hyperenhancement of 51-75 % of WT and 4=hyperenhancement of 76-100 % of WT.In CMR the existence of microvascular obstruction(MO) was also evaluated.Total segment scores(TSS) in R,RD and CMR for each patient were calculated by summing of 17 segment score values. doi = 10.1007/s00259-007-0544-9 id = cord-015359-gf32a6f1 author = nan title = B scientific sessions (SS) date = 2002 keywords = CTA; DSA; DTPA; Doppler; ECG; Germany; MRA; MRI; MSCT; Purpose; Siemens; case; conclusion; contrast; image; material; method; patient; result; study summary = Methods and materials: 73 consecutive patients, clinically considered to have stage 1B tumour (confined to the cervix), underwent MR imaging studies at 1 T, according to the following protocol: fast spin-echo (FSE) T2-weighted, gadoliniumenhanced SE Tl-weighted, and fat-suppressed gadolinium-enhanced SE Tlweighted sequences. Purpose: To describe the radiological (thin section CT) findings correlated to activity and remission in ANCA associated pulmonary-renal small vessel vasculitis (SVV) Material and methods: We used retrospective analysis of 37 CTs, 27 in disease activity (8 first manifestations, 19 relapses) 10 im remission of 17 patients with pulmorenal syndrome (9 Wegener, 4 microscopic polyangiitis-MPA, 3 Churg-Strauss-syndrome, 1 idiopathic crescentic glomerulonephritis following the Chapel Hill classification) 7 women, 10 men, median 65.5 years (34 -84). Varghese, P.R. Mueller; Boston, MA/US Purpose: We sought to determine the incidence of malignancy and to assess a possible role for image guided biopsy of this category of renal masses Materials & methods: Of the 397 renal biopsies performed at our institution between 1991 and 2000; a total of 28 patients with 28 category III lesions, were identified for analysis. doi = 10.1007/s00330-002-0002-9 id = cord-015368-a0qz4tb9 author = nan title = 48th Annual Meeting of the Austrian Society of Surgery, Graz, June 7–9, 2007 date = 2007 keywords = Austria; Background; Department; III; case; complication; conclusion; dna; follow; group; high; mean; method; month; operation; patient; postoperative; procedure; rate; result; study; surgery; surgical; treatment; year summary = Surgical treatment and evaluation, complications, short and long term patency of our patients were compared to interventional techniques and international literature. The aim of the study was to investigate: i) relevant and combined determinants of the development, management and outcome of a representative patient cohort (n ¼ 9.991) with acute appendicitis enrolled in a prospective unicenter study through a time period of 27 years (middle Europe), and ii) the frequency and impact of specific categories (e.g., characteristics of the medical history, clinical and intraoperative findings, complications), correlation and relative risk factors of the disease and its prognosis. From 01=1997 until 12=2006 198 TEM procedures were performed in 194 patients, 104 males, 90 females, mean age was 68.9 years (38-91), the median hospital stay was 8 days . No conversion to open technique had to be performed, no postoperative surgical complications were observed, one patient died 4 weeks postoperative due to liver failure following esophageal varices bleeding. doi = 10.1007/s10353-007-0330-8 id = cord-015372-76xvzvdg author = nan title = National scientific medical meeting 1996 abstracts date = 1996 keywords = CAD; HCV; HIV; HSP; ICU; PCR; age; case; disease; group; increase; irish; level; mean; patient; positive; study; year summary = One, two and five-year survival rates were examined; age at diagnosis and lesion type were extremely significant factors in relation to patient outcome. Patients'' age, sex, risk group, CDC stage, CD4 count, indication for therapy, complication rate and response to treatment are described. Fifty-eight patients (34 male, 24 female) ranging in age from 15 to 65 years (Mean + SD = 28.4 + 10.8) were included in the study. Among these 48 patients (mean age 68.0+12.7), after controlling for age and for the duration and continuity of subsequent antipsychotic treatment, increasing duration of initially untreated psychosis was associated with greater severity of negative symptoms (p<0.005) and with lower scores on the MMSE (p<0.05) but not with executive dysfunction on the EXIT (p=0.3). Conclusion Although not a population based study, care of IDDM in Ireland is almost totally hospital clinic based Cigarette smoking is identified as the major problem to be addressed Patients with diabetes meltitus (DM) are at a higher risk of developing vascular complications, including coronary artery disease (CAD). doi = 10.1007/bf02945204 id = cord-015394-uj7fe5y6 author = nan title = Scientific Abstracts date = 2008-12-23 keywords = ACTH; AEA; ANOVA; BMI; CRF; Center; ELISA; EOC; ERK; GDM; Gynecology; Hospital; IL-1; IL-6; IL-8; IUGR; IVF; LPS; Medical; Medicine; NIH; Netherlands; Obstetrics; P<0.05; PCOS; PCR; PPROM; RNA; Research; School; TNF; USA; University; VEGF; cell; conclusion; control; dna; expression; fetal; fsh; human; increase; level; maternal; method; objective; placental; pregnancy; result; study; western; woman summary = Studies involving immunohistochemical analysis of normal ovaries have shown that granulosa cells express significantly higher levels of the activator protein-1 (AP-1) transcription factor, cFos compared to theca cells, where cFos expression is virtually absent. Following acute hypoxia (0.5% O2) for one to six hours, RhoA mRNA, total protein and activation (RhoA-GTP) levels were analysed, using semi-quantitative PCRs and western blot, and compared to normoxic non-pregnant human uterine smooth muscle control cells. Since there is an urgent need for non-invasive methods for determination of fetal (F) and placental (P) function, this study was designed to evaluate the genes differently and commonly expressed in P tissue and leukocytes in maternal (M) and F circulation.Material and Methods. The current study: 1) localized IL-6 mRNA levels in preeclamptic versus normal decidual sections; 2) evaluated mechanisms regulating IL-6 synthesis by targeting intracellular signaling pathways with specific inhibitors; 3) identified potential IL-6 targets by immunolocalizing the IL-6 receptor (IL-6R) to specific cell types in placental bed biopsies. doi = 10.1177/19337191080150020102 id = cord-015569-vy49r1zd author = nan title = Abstracts from the 45(th) Annual Meeting of Japanese Association for the Stusy of Taste and Smell (JASTS 2011), Kanazawa, Japan, October 5-7(th), 2011 (The president of the meeting was Dr. Takaki Miwa, Kanazawa Medical University) date = 2012-05-17 keywords = Japan; TBD; cell; food; mouse; odor; olfactory; patient; receptor; result; study; taste summary = In this study, in order to test whether the cadherins are required for formation of synapse between gustatory nerve fibers and taste receptor cells, we have investigated expression patterns of cadherin superfamily in the taste buds. Therefore, this study aimed to examine differences in immunoreactivities under various tissue-preparing conditions in rat vallate taste buds for some typical markers of gustatory cells as follows: gustducin, type III inositol triphosphate receptor (IP 3 R3), synaptobrevin-2 (VAMP2), protein gene product 9.5 (PGP9.5), and neural cell adhesion molecule (NCAM). Mainly developing artificial-lipids-based taste sensors with global selectivity, our research group have studied for realization of Ã�taste-odor fusion biosensor system,Ã� which estimates quality (deliciousness and safety) of foods or beverages using several sensor outputs through analysis and evaluation of subjective-objective relation. As a first step, we conducted a series of human sensory tests to investigate perceptual similarities between odorants, and then compared the results with activity patterns evoked on the glomerular layer of the olfactory bulb in rats. doi = 10.1093/chemse/bjs052 id = cord-017248-a37t31u1 author = nan title = Alphabetic Listing of Diseases and Conditions date = 2010-05-17 keywords = Associated; Related; Synonyms; acute; aortic; artery; autopsy; blood; chapter; chronic; condition; death; disease; external; heart; lung; note; poisoning; possible; procedure; pulmonary; record; sample; study; syndrome; term; tissue; type summary = Possible Associated Conditions: Disseminated intravascular coagulation;* eclampsia;* glucose-6-phosphatase deficiency (G6PD); hemolytic uremic syndrome;* malignant hypertension; lymphoma* and other malignancies; paroxysmal nocturnal hemo-globinuria; sickle cell disease;*thalassemia;* thrombotic thrombocytopenic purpura.* (See also below under "NOTE.") NOTE: Hemolysis also may be caused by conditions such as poisoning with chemicals or drugs, heat injury, snake bite,* or infections or may develop as a transfusion reaction* or be secondary to adenocarcinoma, heart valve prostheses (see below), liver disease (see below), renal disease, or congenital erythropoietic porphyria. Unusual under-lying or associated conditions include chronic aortic stenosis or regurgitation; coronary artery anomalies; coronary artery dissection; coronary embolism; coronary ostial stenosis (due to calcification of aortic sinotubular junction or, rarely, to syphilitic aortitis); coronary vasculitis (for instance, in polyarteritis nodosa* or acute hypersensitivity arteritis); hyperthyroidism,* gastrointestinal hemorrhage; * hypothyroidism, * idiopathic arterial calcification of infancy; intramural coronary amyloidosis; pheochromocytoma, polycythemia vera; * pseudoxanthoma elasticum,* radiationinduced coronary stenosis; severe pulmonary hypertension (with right ventricular ischemia); sickle cell disease;* and others. doi = 10.1007/978-1-59745-127-7_17 id = cord-019347-tj3ye1mx author = nan title = ABSTRACT BOOK date = 2010-02-19 keywords = CD4; CD8; CIC; ELISA; FEV1; HIV; ICS; IVIG; OVA; PCN; allergic; allergy; asthma; case; cell; conclusion; group; history; introduction; method; patient; report; result; skin; study; symptom; test; treatment; year summary = Method:Case Report:A 15y/o w/f athlete presented with a two month history of recurrent hives and angioedema which she associated with ingestion of Halloween candy .One week before evaluation she had hives with Coconut as well.Her history was othewise unremarkable except for recurrent UTI''S, annual sinusitis, pneumonia in 1998 as well as migraines.She denied sexual activity.Her physical exam was normal.Results:An evaluation for autoimmune disease revealed normal ESR, ANA, DSDNA, mono and hepatitis serology as well as lyme titers however her CH50 was low17u/ml(normal 26-58U/ml)and evaluation of complement revealed c4 14mg/dl(normal 16-47mg//dl)and c2 <1.3mg/dl(normal 1.6-3.5mg/dl)with normal c3, c5-c9.Her father had nor-malc4 but c2 was 1.4mg/dl (normal 1.6-3.5mg/dl)Her sister had c2 of 1.5mg/dl and normal c4 and her mother had normal c2 and c4.Her workup included positive prick skin test to ragweed, ash and grass and she was started on Rhinocort and Clarinex seasonally.She has been followed for one year with resolution of hives and is asymptomatic.Her diagnosis had been confirmed by a pediatric rheumatologist.Conclusion;We present an atypical case of C2 complement deficiency in an currently asymptomatic individual. doi = 10.1016/s1081-1206(10)61294-x id = cord-019490-m1cuuehi author = nan title = Abstracts cont. date = 2015-12-28 keywords = AUC; CIP; ESBL; Enterobacteriaceae; GISA; GRN; MIC; MIC90; MRSA; NCCLS; PCR; PFGE; Staphylococcus; gram; infection; isolate; method; objective; patient; resistance; result; strain; study; test summary = Tigecycline Evaluation Surveillance Trial (TEST) -Global in vitro antibacterial activity against selected species of glucose non-fermenting organisms Objective: Despite the introduction of new antimicrobials to treat resistant gram-positive bacteria, Staphylococcus aureus continues to be a therapeutic challenge for the clinician. Two prospective studies from our centre identified common causes of CAP in India to be Mycoplasma pneumoniae [MP] and Legionella pneumophila [LP] by serology in 11% each, and SPN in 10% by culture of respiratory secretions/blood/ Conclusion: Although SPN is the most common isolate, the rising numbers of gram negative organisms (38%) and atypical pathogens associated with increasing mortality stress the need for review of initial antibiotic choice for adults with higher PORT classes. Conclusion: The spectrum of isolates among our patients were shifting towards gram positive bacteria with high resistance to different groups of antimicrobial agents limiting few choices for alternative therapies for infection control. doi = 10.1111/j.1469-0691.2005.clm_1134_02.x id = cord-020316-xr9h4c1q author = nan title = Million women study most wanted in 2003 date = 2004-04-10 keywords = Study summary = key: cord-020316-xr9h4c1q authors: nan cord_uid: xr9h4c1q nan MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebo-controlled trial Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial Advances in cystic fibrosis Cystic fibrosis Elusive schizophrenia genes Genes for schizophrenia? Detecting ovarian cancer Use of proteomic patterns in serum to identify ovarian cancer Heart Protection Study Collaborative Group. Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): a randomised controlled trial doi = 10.1016/s0140-6736(04)15948-5 id = cord-021206-4zyqqgs0 author = nan title = Scientific and Educational Exhibits date = 2007 keywords = ADC; CTA; DWI; Doppler; ECG; FDG; Learning; MDCT; MRI; Objectives; PET; conclusion; detail; finding; image; imaging; material; method; patient; purpose; result; study summary = Purpose: To analyze the clinical and imaging fi ndings of BI-RADS category 3 breast lesions by mammographic and ultrasonographic (US) assessment ultimately diagnosed as malignancy in retrospect Methods and Materials: Of 3,207 cases of US-guided core needle biopsy for 4 years, category 3 was given after biopsy, based on mammographic and sonographic evaluation, in 1,099 lesions (41.7%) that were composed of 462 palpable and 637 nonpalpable lesions. Background: Regional kinesis alteration of IVS is associated with different cardiac conditions which may have both pathological and physiological meanings of which the most important are the following: a) left bundle branch block that may determine intra-left ventricular asynchrony and may represent an independent predictor of severe cardiac events in heart failure patients; b) pulmonary embolism that increase right ventricle pressure; c) constrictive pericarditis; d) restrictive cardiomyopathies; e) post-operative cardiac surgery. doi = 10.1007/s10406-007-0215-8 id = cord-022501-9wnmdvg5 author = nan title = P1460 – P1884 date = 2015-12-28 keywords = 16S; CDAD; CFU; ELISA; ESBL; Enterococcus; GRN; ICU; MIC; MRSA; PCR; Staphylococcus; TGC; dna; gram; infection; isolate; method; objective; patient; resistance; result; strain; study summary = Methods: Using published data on (1) the prevalence of MRSA and other bacterial pathogens causing cSSSI in the US, (2) the in-vitro susceptibility rates of commonly used regimens in cSSSI in the US in relation to the most pervasive pathogens identified above, and (3) estimated costs of failure of initial, empiric treatment from a recent study of a large US multi-hospital database, we developed a model to predict the expected clinical and economic impact of increasing prevalence of MRSA. Small outbreaks of VEB-1 ESBL producing Acinetobacter baumannii in Belgian nursing homes and hospitals through cross-border transfer of patients from northern France Methods: From 01/04 to 03/05, all Belgian acute hospitals were invited to report cases of nosocomial infections/colonisations due to MDR Ab isolates presenting a resistance profile similar to the French epidemic strain (resistance to all agents except carbapenems and colistin) and to send such isolates to the reference laboratory for phenotypic confirmation and for genotypic characterization (PCR of VEB-1 and class 1 Integron, PFGE typing). doi = 10.1111/j.1470-9465.2006.12_4_1431.x id = cord-022527-a0x6lws3 author = nan title = Eosinophils in Human Disease date = 2012-10-12 keywords = AHR; CD34; CRS; CSF; DES; ECP; EDN; EGID; HES; IL-4; IL-5; MBP; asthma; cell; eosinophil; patient; study summary = The role of the eosinophils as key players in the pathophysiology of asthma has been debated, despite evidence that the cells are present and activated in the airway lumen and tissue 1 of patients with current asthma; are increased in number when asthma is uncontrolled 2 or severe 3 and decreased when asthma is controlled 4 ; and treatment strategies that aim to control airway eosinophilia are significantly more effective and less expensive in improving asthma control 5,6 and decreasing asthma exacerbations compared to guideline-based clinical strategies. 11 Since allergic asthma is primarily a T-helper type 2 (T h 2)-mediated disease, it is not surprising that cytokines driving eosinophilia are T h 2 cell products: specifically, granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and interleukin-5 (IL-5), which signal through specific high-affinity cell-surface receptors linked to a common b-chaindall of which can act as eosinophil growth factors that promote formation of eosinophil/basophil (Eo/B) colony-forming units (CFU) in functional assays. doi = 10.1016/b978-0-12-394385-9.00013-4 id = cord-022633-fr55uod6 author = nan title = SAEM Abstracts, Plenary Session date = 2012-04-26 keywords = ACS; AED; Background; COPD; CPR; EMS; ETCO; Emergency; HIV; Hospital; ICU; IQR; LOS; MDD; OHCA; TBI; University; conclusion; datum; group; level; method; objective; patient; rate; result; study; time summary = Staff satisfaction was evaluated through pre/ post-shift and study surveys; administrative data (physician initial assessment (PIA), length of stay (LOS), patients leaving without being seen (LWBS) and against medical advice [LAMA] ) were collected from an electronic, real-time ED information system. Communication Background: The link between extended shift lengths, sleepiness, and occupational injury or illness has been shown, in other health care populations, to be an important and preventable public health concern but heretofore has not been fully described in emergency medical services (EMS Objectives: To assess the effect of an ED-based computer screening and referral intervention for IPV victims and to determine what characteristics resulted in a positive change in their safety. Objectives: Using data from longitudinal surveys by the American Board of Emergency Medicine, the primary objective of this study was to evaluate if resident self-assessments of performance in required competencies improve over the course of graduate medical training and in the years following. doi = 10.1111/j.1553-2712.2012.01332.x id = cord-022650-phsr10jp author = nan title = Abstracts TPS date = 2018-08-14 keywords = AIT; Ara; Background; Der; ELISA; FEV1; HAE; HDM; Hospital; IgE; LTP; PR-10; SCIT; SDS; SLIT; SPT; allergen; allergic; allergy; asthma; case; conclusion; food; group; high; level; method; patient; result; specific; study; symptom; test; treatment; year summary = 0685 | Skin prick test reactivity to aeroallergens in adult allergy clinic in a tertiary hospital: a 12-year retrospective study Results: Five different human sera were screened for specific IgE level against 29 different allergen sources using test methods of three different suppliers. Conclusion: This multicenter prospective study confirmed that stepwise single-dose OFC to egg will help to clarify the severity of egg allergy, and will contribute to improved food allergy manageMethod: The study design was a retrospective cohort study extracting data from the electronic chart of children older than 4 years who visited our out-patient clinic for egg or milk allergy and who underwent an oral food challenge test (OFC) twice within 24 months between November 2013 and December 2017. Results: In the base case analysis, using Italy clinical practice patients with moderate-to severe allergic rhino-conjunctivitis (SS ranging from 6 to 15 points) and a mean age at entry of 21 years, both SCIT and SLIT were associated with increased cost but superior efficacy compared to pharmacotherapy alone. doi = 10.1111/all.13539 id = cord-022653-qa1uph35 author = nan title = Poster Discussion Session PDS date = 2017-08-30 keywords = AIT; CD4; Der; ELISA; HDM; IgE; P<.001; allergen; allergic; allergy; asthma; cell; child; conclusion; group; introduction; level; objective; patient; result; study; test; treatment; year summary = 0206 | G protein coupled receptor kinase 2 (GRK2) regulates endothelial permeability induced by Bradykinin 0208 | Pharmacokinetics (PK) and pharmacodynamics (PD) of c1 esterase inhibitor of chronic urticaria challenges most commonly identified were the following: time of onset of disease; frequency/duration of and provoking factors for wheals; diurnal variation; occurrence in relation to weekends, holidays, and foreign travel; shape, size, and distribution of wheals; associated angioedema; associated subjective symptoms of lesions; family and personal history regarding urticaria, atopy; previous or current allergies, infections, internal diseases, or other possible causes; psychosomatic and psychiatric diseases; surgical implantations and events during surgery; gastric/ intestinal problems; induction by physical agents or exercise; use of drugs; food allergies; relationship to the menstrual cycle; smoking habits; type of work, hobbies; stress; quality of life and emotional impact; previous therapy and response to therapy, and previous diagnostic procedures/results. doi = 10.1111/all.13251 id = cord-022659-chwk2bs4 author = nan title = Abstracts: Poster session date = 2004-10-08 keywords = ALS; Alzheimer; Association; CNS; CSF; GBS; HTLV; MBP; MRI; Neurological; Parkinson; age; cell; control; day; disease; patient; study; test summary = We investigated the usefulness of informant-based data in Alzheimer''s disease (AD) by comparing caregivers'' subjective evaluations of 83 probable A D patients'' performance on an abbreviated version of the Memory Self-Report Questionnaire to objective evaluations derived from an extensive battery of neuropsychological tests and to clinicians'' evaluations. Compared with 89 subjects (mean age 75.2 yr; 34 men, 55 women) with dementia of the Alzheimer type (DAT), there were no significant group differences for comparable Clinical Dementia Rating stages of dementia for measures of language, Activities of Daily Living, or general cognition. The mean age at onset did not differ significantly between handedness groups (F [ l,lOO] = .82), but the mean duration of symptoms ( Alterations in the optical properties of brain can be used to detect pathological changes in patients with Alzheimer''s disease (AD). doi = 10.1002/ana.410320224 id = cord-022888-dnsdg04n author = nan title = Poster Sessions date = 2009-08-19 keywords = APC; BCR; CD14; CD4; CD8; CMV; CTL; EBV; ELISA; Germany; HCV; HIV; HLA; IBD; IFN; IL-10; IL-2; IL-4; IL-6; Immunology; Institute; LPS; MHC; NKT; PCR; RNA; SLE; TCR; TGF; TLR; TLR4; TNF; University; antigen; cell; dna; expression; immune; mouse; patient; protein; response; result; study; th1; th2 summary = Methods: Phospho-specific Western blot analyses were performed to verify the functionality of the different IFN-g pathway components, intra-and extracellular flow cytometry experiments were employed to determine the expression of antigen processing components and HLA class I cell surface antigens, quantitative real time-PCR experiments to confirm the absence of JAK2 and presence of pathway relevant molecules as well as, genomic PCR and chromosome typing technique to prove the deletion of JAK2. In order to accomplish these objectives we induced priming or tolerance of ovalbumin (OVA 323-339 peptide)-specific T cells from DO11.10 TCR transgenic mice in vitro or, following adoptive transfer of near physiologically relevant numbers of such cells into recipients, in vivo and correlated functional outcome (via proliferation and cytokine readout assays or antibody production) with E3 ubiquitin-protein ligases expression and the ubiquitination status of the TCR signalling machinery. doi = 10.1002/eji.200990224 id = cord-022940-atbjwpo5 author = nan title = Poster Sessions date = 2016-09-07 keywords = Akt; Ankara; Biology; Department; ELISA; Faculty; GSH; HCC; IL-6; IMA; Institute; Istanbul; MCF-7; MDA; MTT; P-02.08.5; P-09.04.4; PCR; PON1; RNA; ROS; Research; Russian; SOD; Sciences; TAS; TNF; TOS; Turkey; University; activity; analysis; cancer; cell; conclusion; control; dna; effect; expression; gene; group; high; increase; introduction; level; method; patient; protein; result; study; tissue; treatment; turkish; western summary = We have studied the effect of inhibition of IRE1 (inositol requiring enzyme 1), which is a central mediator of endoplasmic reticulum stress and controls cell proliferation and tumor growth, on hypoxic regulation of the expression of different proliferation related genes in U87 glioma cells. Transient inhibition of Akt and mTOR protein kinase activation in tumor cells followed by reactivation of signaling pathway did not result in a time-dependent difference on EGFR, HER2 and HER3 expression levels. In our study we aimed to determine cytotoxic effect of RES in K562 human CML cell line and to evaluate the expressions of miRNAs that are associated with genetics of leukemia after treatment with RES; to investigate target genes of miRNAs which show significant expression alterations and molecular mechanisms of RES treatment. doi = 10.1111/febs.13808 id = cord-022955-vy0qgtll author = nan title = Proteases date = 2005-06-20 keywords = APC; GCPII; Met; University; activity; cell; enzyme; human; inhibitor; nedd4; peptide; protease; protein; result; serine; site; study; substrate summary = In order to understand the molecular basis of the enzyme-substrate binding mechanism, we employ the synthetic peptide and mass spectrometry-based approaches to investigate the significance of selected amino acid residues that are flanking both sides of the SARS-CoV 3CL pro cleavage site. To contribute to the assignment of a physiological role to genomic-derived peptidases and to make them more accessible for the drug discovery process, we have undertaken a program consisting of mRNA expression profiling, full-length recombinant expression in insect cells, purification and determination of the catalytic activity for the human proteolytic enzymes. This comprehensive analysis of the local backbone properties of SGTI in the free and in the complex form made possible to identify conformational similarities and differences responsible for its efficient binding to the enzyme, and provides a good basis for further studying the structural aspects of protease inhibitor specificity. doi = 10.1111/j.1742-4658.2005.4739_4.x id = cord-023017-k6edtg58 author = nan title = AASLD Abstracts (pp. 282A–382A) date = 2006-02-10 keywords = CD4; CD8; HCC; HCV; HIV; HSC; IFN; MELD; OLT; PCR; RNA; SVR; alt; cell; conclusion; day; group; liver; method; patient; result; study summary = 14/55 (25%) patients in AC who did not discontinue by week 24 received ribavirin dose reduction in comparison to 31/108 ( The clinical outcome in response to combination therapy for treatment of chronic hepatitis C virus (HCV) infection appears to be different for Caucasian versus African American patients. Over the period of combination therapy, most patients in which serum virus titers were reduced to non detectable levels had significant increases in T cell responses to HCV proteins. CHRONIC Background: Recent large prospective trials demonstrated that the combination therapy of interferon (1FN)-alphalribavirin significantly increased the ratio of a sustained virological response in patients with chronic hepatitis C in comparison with IFN monotherapy, especially in patients with high HCV-RNA titer and genotype lb. Results: Patients with chronic HCV infection showed higher MxA gene expression levels than healthy controls, indicating that hepatitis C virus induces IFN production. doi = 10.1002/hep.1840380505 id = cord-023026-2r84ndzv author = nan title = Posters date = 2013-06-14 keywords = ATP; Alzheimer; BBB; BDNF; CNS; EAE; GABA; GFAP; GFP; GLT-1; IL-6; LPS; MBP; NMDA; OPC; PCR; SCI; SOD1; SVZ; Schwann; University; astrocyte; brain; cell; expression; increase; microglia; mouse; ng2; protein; result; role; study summary = Thus, this work provides the basis to identify molecular pathways regulated by distinct niche/environmental signals and involved in the heterogeneity of adult OPCs. Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative demyelinating disease of the central nervous system (CNS) characterized by inflammation, which leads to formation of demyelinating areas due to loss of oligodendrocytes, astrogliosis and, finally, axonal degeneration. Taken together, these results demonstrate the important role of miR-200b in modulating the MAPK pathway via c-Jun which in turn affects different aspects of the inflammatory process accompanying microglia activation including cytokine response, NO production, phagocytosis and neuronal cell death. For this purpose, coronal cryostat free-floating sections from the brain of both adult transgenic mice and their corresponding wild-type (Wt) littermates, were processed for the study of astrocytes using GFAP immunohistochemistry and microglia using antibodies against Iba1 and several markers commonly related to the activated phenotype of these microglial cells, such as CD16/32 (Fc receptor), F4/80, CD11b, CD206, CD150 and MHC-II. doi = 10.1002/glia.22530 id = cord-023049-fio7cjj5 author = nan title = 2017 Peripheral Nerve Society Meeting July 8–12, 2017 Sitges, Barcelona, Spain date = 2017-06-22 keywords = AMAN; Barré; CIDP; CMT; CSA; Center; Charcot; DRG; Department; EMG; FAP; France; GBS; GM1; Guillain; Hospital; IENFD; IVIG; Institute; Italy; Japan; MMN; MRC; MRI; Marie; Medical; Medicine; NCS; National; Neurology; Neuropathy; PMP22; PNS; School; Schwann; Singapore; TTR; Tooth; USA; University; cmt1a; mag; nerve; patient; study summary = Clinical efficacy (Medical Research Council sum score, 10-m walk, modified Inflammatory Neuropathy Cause and Treatment score, Overall Neuropathy Limitations Scale, Romberg test) and patient-reported outcomes (36-item Short Form Health Survey , Life Quality Index [LQI] ) were assessed at baseline and at regular intervals until the final visit (10-14 months after switching). To explore the issue of early biomarkers in FAP, we performed skin biopsy and compared IENF density with parameters of nerve conduction studies (NCS) and quantitative sensory testing (QST) on 36 subjects (23 men, aged 55.1 ± 11.1 years) with genetic confirmation of TTR-A97S: 17 patients and 19 carriers. Results: The Gly112Ser mutation causing CMT1C is a mild form of CMT, as patients walked on time, had less weakness than those with Charcot-Marie-Tooth Disease type 1A (CMT1A), had a Charcot Marie Tooth neuropathy score (CMTNS) indicative of mild disease, and had faster ulnar and median motor nerve conduction velocities compared to those with CMT1A. doi = 10.1111/jns.12225 id = cord-023095-4dannjjm author = nan title = Research Abstract Program of the 2011 ACVIM Forum Denver, Colorado, June 15–18, 2011 date = 2011-05-03 keywords = ACTH; CHF; CKCS; CKD; DMVD; ECG; ELISA; IBD; PCR; TLR5; University; Veterinary; blood; cat; concentration; day; disease; dna; dog; group; horse; sample; study; test; time; treatment summary = The purpose of this study was to determine the short-term effects of ivabradine on heart rate (HR), blood pressure, left ventricular (LV) systolic and diastolic function, left atrial (LA) performance, and clinical tolerance in healthy cats after repeated oral doses. The goal of this study was to investigate the relationship between heart rate and ECG time intervals to body mass in apparently healthy horses and ponies and to calculate normal ranges for different weight groups. This study aimed to investigate the prevalence of hypercoagulability in PLN dogs based on thromboelastography (TEG), and to determine whether hypercoagulability in these patients could be predicted by clinical assessments that identify systemic hypertension (systolic blood pressure 4 160 mmHg), hypoalbuminemia (serum albumin o 2.7 mg/dl), antithrombin activity (o 70%), and degree of proteinuria (urine protein:creatinine ratio [UPC] ! doi = 10.1111/j.1939-1676.2011.0726.x id = cord-023134-y665agnh author = nan title = Oral Research Communications of the 22(nd) ECVIM‐CA Congress date = 2012-11-20 keywords = BEM; CKD; DCM; IBD; IPF; PCR; SAM; cat; disease; dog; group; study summary = Doppler echocardiographic indices of diastolic function of the right ventricle are good prognostic markers during left ventricular (LV) failure secondary to ischemic and dilated cardiomyopathy.The aims of the present study were: to assess LV and RV diastolic function by conventional Doppler and pulsed-wave tissue Doppler imaging (PW-TDI) in dogs with mitral valve disease (MVD), with or without pulmonary hypertension (PH); to test if echocardiographic parameters of LV and RV diastolic dysfunction correlate to the Doppler-estimated pulmonary artery systolic pressure (PASP).114 dogs were prospectively evaluated, including 86 dogs with MVD. The aims of the present study were to assess whether diabetic cats have pathological evidence of islet inflammation or pancreatitis and to define islet lesions in comparison to a well-matched control population.Formalin-fixed, paraffin-embedded pancreatic samples were collected from post-mortem examination performed on diabetic and control cats died due to any disease at the Clinic for Small Animal Internal Medicine, University of Zurich (Switzerland) between 1997 and 2009. doi = 10.1111/jvim.12000 id = cord-023157-0lqlx2rv author = nan title = Poster Sessions date = 2013-04-18 keywords = BMI; CAD; CRP; CVD; GDM; HDL; HFD; HOMA; Hospital; IFG; IGT; IL-6; NAFLD; OGTT; PCOS; T2DM; University; diabetes; glucose; group; high; insulin; level; metabolic; patient; result; study summary = The patients revealed the increase of free fatty acids level (2.19 AE 0.10) mmol/l/ml, that meaningfully differed from such indexes in the control group (P < 0.001) and low level of adiponektin (3.70 AE 0.70) mg/ml that confirms their role in development of NAFLD even for persons with normal body weight after the presence of abdominal type of adipose tissue distribution. Results: This study has shown effectiveness in reduction in fasting blood glucose (P < 0.01), systolic blood pressure (P = 0.03), diastolic blood pressure (P = 0.01), weight (P = 0.03), added sugar (P = 0.03) and fat consumption (P < 0.01) while improving physical activity (P < 0.01) and insulin sensitivity (P < 0.01) in the intervention group when compared with the control group at follow up assessment. Conclusion: Our study shows that infiltration of macrophages in human adipose tissue, estimated by the expression of macrophage markers, is increased in subjects with obesity and diabetes and associated with insulin sensitivity and serum lipid levels independent of BMI. doi = 10.1111/1753-0407.12032_1 id = cord-023186-gqltd6u0 author = nan title = Poster Sessions date = 2019-06-27 keywords = CPAP; OSA; PICU; case; child; group; patient; study summary = Methods: This is a one-year retrospective study that was conducted in our pediatric intensive care unit (PICU) comparing the intervention failure rate of three different Noninvasive respiratory support modalities (bi-level positive airway pressure (BIPAP), continuous positive airway pressure (CPAP) and HFNC) for infants and young children between the ages of 1 month and 2 years admitted with the diagnosis of bronchiolitis. The aim of the study was to determine the association between Methods: Ninety children aged between > 28 days to < 5 years hospitalized with diagnosis of severe CAP in the Pediatric Department of West Nusa Tenggara Province General Hospital from January to October 2018 were enrolled. Arterial blood gases, respiratory rate, peak inspiratory pressure (PIP) and mean airway pressure (MAP) of rat lung during respiratory support, wetto-dry lung weight ratio, lung homogenate and/or bronchoalveolar lavage fluid tumor necrosis factor-α, macrophage inflammatory protein-2, interleukin-6 and total protein levels were measured and compared among groups after study completion. doi = 10.1002/ppul.24373 id = cord-023208-w99gc5nx author = nan title = Poster Presentation Abstracts date = 2006-09-01 keywords = Fmoc; Gly; HPLC; Lys; NH2; NMR; Pro; RGD; RNA; Tyr; acid; activity; amino; bind; cell; dna; high; interaction; method; peptide; protein; receptor; result; sequence; structure; study summary = In order to develop a synthetic protocol by an automated instrumentation, increasing yield, purity of the crude, and reaction time, a microwave-assisted solid phase peptide synthesis was validated comparing the use of the new generation of Triazine-Based Coupling Reagents (TBCRs) with a series of commonly used ones. Ubiquitinium is a well known mechanism in protein degredation of Eukaryotic cells ,in which many obsolte and corrupted three dimentional structure protein ,become marked by covalent attachment of ubuquitin through a multi-step enzymatic pathway.Ubiquitin is a small ,8.5 kDa peptide of 76 amino acid residues that targets such substrtes for proteolysis in proteasome .Recnt studies showed that an extra cellular ubiquitination process also taking place in the epididymes of humans and other animals marks protein on the surface of the defective sperm .it appears that structurally and functionally defective sperm become surface ubiquitinated by epididymal epithelial cells. This head-to-tailcyclized 14-amino-acid peptide contains one disulfide bridge and a lysine residue (Lys5) present in the P1 position, which is responsible for inhibitor specificity.As was reported by us and other groups, SFTI-1 analogues with one cycle only retain trypsin inhibitory activity. doi = 10.1002/psc.797 id = cord-023209-un2ysc2v author = nan title = Poster Presentations date = 2008-10-07 keywords = Ala; Arg; Asp; Fmoc; Glu; Gly; HPLC; Leu; Lys; NMR; Phe; Thr; Trp; Tyr; University; VEGF; Val; acid; activity; amino; bind; cell; dna; high; peptide; pro; protein; receptor; residue; result; sequence; structure; study; synthesis summary = Site-specifi c PEGylation of human IgG1-Fab using a rationally designed trypsin variant In the present contribution we report on a novel, highly selective biocatalytic method enabling C-terminal modifi cations of proteins with artifi cial functionalities under native state conditions. Recently, our group report a novel approach to a totally synthetic vaccine which consists of FMDV (Foot and Mouth Disease Virus) VP1 peptides, prepared by covalent conjugation of peptide biomolecules with membrane active carbochain polyelectrolytes In the present study, peptide epitops of VP1 protein both 135-161(P1) amino acid residues (Ser-Lys-Tyr-Ser-Thr-Thr-Gly-Glu-Arg-Thr-Arg-Thr-Arg-Gly-Asp-Leu-Gly-Ala-Leu-Ala-Ala-Arg-Val-Ala-Thr-Gln-Leu-Pro-Ala) and triptophan (Trp) containing on the N terminus 135-161 amino acid residues (Trp-135-161) (P2) were synthesized by using the microwave assisted solid-phase methods. Using as a template a peptide, already identifi ed, with agonist activity against PTPRJ(H-[Cys-His-His-Asn-Leu-Thr-His-Ala-Cys]-OH), here we report a structure-activity study carried out through endocyclic modifi cations (Ala-scan, D-substitutions, single residue deletions, substitutions of the disulfi de bridge) and the preliminary biological results of this set of compounds. doi = 10.1002/psc.1090 id = cord-023211-kt5gt26t author = nan title = Poster Session Abstracts date = 2007-08-29 keywords = ASL; ATP; BMI; CFF; CFQ; CFRD; CFTR; Center; Cystic; DHA; FEV1; FVC; Fibrosis; Foundation; GFP; HBE; Hospital; IL-8; Isc; MRSA; Medical; NBD1; NIH; PCR; PKA; Pseudomonas; USA; United; University; airway; cell; conclusion; dna; increase; lung; method; patient; result; study; ∆F508; ∆F508-CFTR summary = Previous studies performed using fluorescence halide efflux measurements and short-circuit current voltage clamp have shown that treatment with PPARγ (peroxisome proliferator activated receptor gamma) agonists, such as pioglitazone and FLL (FMOC-L-leucine), resulted in an increased biosynthesis and trafficking of ∆F508-CFTR to the cell surface. Physiology, School of Medical Sciences, University of Bristol, Bristol, United Kingdom Recent progress in the development of small molecule correctors and potentiators capable of restoring CFTR function have increased the need for pre-clinical test models including cultured airway epithelial cells from human CF patients as well as CF mouse models. Clinical studies have linked increased sputum and peripheral blood neutrophil MPO activity with increased airflow obstruction in cystic fibrosis (CF) patients of the same age, gender, airway bacterial flora, and CFTR genotype. Because patients expressing low levels of normal CFTR mRNA (5-20%) have mild disease symptoms, these studies demonstrate that the incorporation of the ciliated cell-specific FOXJ1 promoter into gene therapy vectors may be useful for treatment of CF. doi = 10.1002/ppul.20700 id = cord-023216-avn8f2w3 author = nan title = Symposium summaries date = 2004-10-18 keywords = ASL; ATP; Bcc; CFLD; CFRD; CFTR; Cystic; Fibrosis; NBD1; PKC; Pseudomonas; airway; care; cell; disease; lung; pain; patient; study summary = • relevant past history • recently recommended home physiotherapy program including inhalation therapy (agents, order and timing), airway clearance therapy (ACT) and physical exercise program and adherence • the possibility of gastroesophageal reflux 5 in relation to physiotherapy • clinical status including subjective and objective measures of the following -amount, color, consistency and ease of expectoration of sputum -oximetry/pulmonary function tests/peak expiratory flow rate -breath sounds on auscultation, respiratory rate and pattern of breathing -exercise tolerance (current activity & incidental exercise/ exercise tolerance tests) -musculo-skeletal problems (posture, pain, muscle tightness/weakness, oedema) -urinary incontinence during coughing and forced expirations Assessment of health related quality of life (HRQOL) in children and adolescents with cystic fibrosis (CF) is important to better understand disease and treatment-related factors that impact function and well-being, and to evaluate the effectiveness of therapies and methods of drug delivery. doi = 10.1002/ppul.20142 id = cord-023225-5quigar4 author = nan title = Posters date = 2012-08-21 keywords = Aib; Ang; Cys; Fmoc; Gly; HPLC; Ile; Leu; Lys; NMR; PNA; Phe; SPPS; University; acid; activity; amino; cell; dna; group; peptide; protein; residue; structure; study; synthesis summary = To further explore the structure-function relationship, a viable synthesis strategy for pseudodesmin A analogues was developed, based on side-chain attachment of the first amino acid to the solid support, followed by stepwise Fmoc solid-phase synthesis of the linear peptide precursor and on-resin head-to-tail cyclization. The cases when the amino acid sequence of a fragment coincided with part of the primary structure of a natural oligopeptide were recorded in the Total protein chemical synthesis requires a case by case design and optimization which is governed by factors such as the solubility of the individual peptide segments, their primary sequence and in particular the presence of "difficult" amino acid residues at ligation junctions such as proline or the location of cysteines. In this study we present synthesis of two series of peptide libraries, which were designed by substitution of Leu in the P5, P6 position of our control peptide (Ac-LLLLRVKR-AMBA) with each of nineteen amino acid residues in order to verifying its influence on activity and selectivity of the resulting analogues. doi = 10.1002/psc.2449 id = cord-023239-06a03o14 author = nan title = II. Topic Sessions date = 2016-06-10 keywords = CFTR; FEV; GWAS; NCPAP; OSAS; PCD; RSV; airway; asthma; child; disease; function; lung; patient; study summary = The basics of inhaler technique / device / adherence / allergen exposure are all being maintained A retrospective analysis of follow-up of children with difficult asthma for up to six years revealed that those in whom underlying modifiable factors were identified and addressed had an improvement in lung function and reduction in exacerbations over time, while being able to reduce maintenance dose of inhaled steroids such that the majority fell below the threshold for problematic severe asthma 4 . Long-term follow up of children investigated in infancy and reassessed in later childhood have so far showed that reduced baseline lung function in symptomatic infants was significantly associated with subsequent respiratory morbidity as well as with the need of anti-asthma medication at the age of 3 years. doi = 10.1002/ppul.23455 id = cord-023288-sqr33y72 author = nan title = Paediatric SIG: Poster Session date = 2008-03-12 keywords = COPD; FEV1; IL-6; OSA; PCR; asm; asthma; cell; increase; lung; patient; result; study summary = Results Data indicate splice variant expression in dendritic cells from asthmatic patients is influenced by asthma severity. Methods Randomized controlled trials (RCTs) of GORD treatment in adults or children that reported asthma health outcomes and had symptomatic GORD were included and assessed in accordance with the standard Cochrane systematic review process. Results 11 male (44%) and 14 female (56%) patients with moderate to severe persistent asthma (mean age 44 years, SD = 11) participated. Methods A comprehensive range of intracellular T-cell and monocyte proand anti-inflammatory cytokines/chemokines was investigated in peripheral blood from 5 OSA patients and 5 aged-matched control subjects (with no evidence of sleep problems) using multiparameter flow cytometry. Methods Following completion of a 12-month exercise study, which included a supervised program (Intervention, n = 18) and control group (Control, n = 17), COPD subjects [mean age (SD): 66 (8); mean FEV1 (% predicted) = 56% (19)] were asked to complete a questionnaire. doi = 10.1111/j.1440-1843.2008.01252_11.x id = cord-023298-ysur3sjq author = nan title = Respiratory Nurses SIG: Poster Session date = 2011-03-21 keywords = ASM; COPD; FEV; HRV; Interest; Nil; airway; cell; increase; method; patient; result; study summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. doi = 10.1111/j.1440-1843.2011.01937_16.x id = cord-023302-p9pxz44a author = nan title = Cystic Fibrosis SIG: Poster Session date = 2011-03-21 keywords = ASM; COPD; FEV; HRV; Interest; Nil; airway; cell; increase; method; patient; result; study summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. doi = 10.1111/j.1440-1843.2011.01937_7.x id = cord-023303-fxus38mp author = nan title = Lung Cancer/Bronchology SIGs: Combined Poster Session date = 2008-03-12 keywords = COPD; FEV1; IL-6; OSA; PCR; asm; asthma; cell; increase; lung; patient; result; study summary = Results Data indicate splice variant expression in dendritic cells from asthmatic patients is influenced by asthma severity. Methods Randomized controlled trials (RCTs) of GORD treatment in adults or children that reported asthma health outcomes and had symptomatic GORD were included and assessed in accordance with the standard Cochrane systematic review process. Results 11 male (44%) and 14 female (56%) patients with moderate to severe persistent asthma (mean age 44 years, SD = 11) participated. Methods A comprehensive range of intracellular T-cell and monocyte proand anti-inflammatory cytokines/chemokines was investigated in peripheral blood from 5 OSA patients and 5 aged-matched control subjects (with no evidence of sleep problems) using multiparameter flow cytometry. Methods Following completion of a 12-month exercise study, which included a supervised program (Intervention, n = 18) and control group (Control, n = 17), COPD subjects [mean age (SD): 66 (8); mean FEV1 (% predicted) = 56% (19)] were asked to complete a questionnaire. doi = 10.1111/j.1440-1843.2008.01252_8.x id = cord-023305-5lb9kho6 author = nan title = Oliv SIG: Poster Session date = 2011-03-21 keywords = ASM; COPD; FEV; HRV; Interest; Nil; airway; cell; increase; method; patient; result; study summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. doi = 10.1111/j.1440-1843.2011.01937_11.x id = cord-023308-af5nihyi author = nan title = COPD SIG: Poster Session 2 date = 2008-03-12 keywords = COPD; FEV1; IL-6; OSA; PCR; asm; asthma; cell; increase; lung; patient; result; study summary = Results Data indicate splice variant expression in dendritic cells from asthmatic patients is influenced by asthma severity. Methods Randomized controlled trials (RCTs) of GORD treatment in adults or children that reported asthma health outcomes and had symptomatic GORD were included and assessed in accordance with the standard Cochrane systematic review process. Results 11 male (44%) and 14 female (56%) patients with moderate to severe persistent asthma (mean age 44 years, SD = 11) participated. Methods A comprehensive range of intracellular T-cell and monocyte proand anti-inflammatory cytokines/chemokines was investigated in peripheral blood from 5 OSA patients and 5 aged-matched control subjects (with no evidence of sleep problems) using multiparameter flow cytometry. Methods Following completion of a 12-month exercise study, which included a supervised program (Intervention, n = 18) and control group (Control, n = 17), COPD subjects [mean age (SD): 66 (8); mean FEV1 (% predicted) = 56% (19)] were asked to complete a questionnaire. doi = 10.1111/j.1440-1843.2008.01252_6.x id = cord-023311-7wqdlha4 author = nan title = Oral Session date = 2010-11-24 keywords = COPD; CPFE; group; lung; patient; pulmonary; result; signifi; study summary = Methods We determined the usefulness of preoperative lung function by spirometry in predicting regression of pulmonary hypertension after surgical correction of mitral stenosis among 20 patients who underwent mitral valve surgery at Philippine Heart Center from July to December 2009. Elderly patients exhibited a signifi cantly higher mortality rate that was independently associated with the following: age; residence status; confusion, urea, respiratory frequency and blood pressure (CURB) score; comorbid conditions; and failure of initial therapy. Methods A total of 40 patients (Male: 50%; Female: 50%) admitted and diagnosed with HAP at our Center were followed up to investigate the rate of adherence of physicians on the diagnosis and treatment of HAP based on Level I and II ATS/IDSA 2008 recommendations and to determine its association with outcome (mortality, mechanical ventilation, ICU stay, hospital stay). doi = 10.1111/j.1440-1843.2010.01864.x id = cord-023314-rwjxk8v4 author = nan title = Asthma & Allergy SIG: Poster Session 1 date = 2011-03-21 keywords = ASM; COPD; FEV; HRV; Interest; Nil; airway; cell; increase; method; patient; result; study summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. doi = 10.1111/j.1440-1843.2011.01937_1.x id = cord-023331-jrvmgnu3 author = nan title = Asthma & Allergy SIG: Poster Session 3. Physiology, Environment, Investigation and Management date = 2008-03-12 keywords = COPD; FEV1; IL-6; OSA; PCR; asm; asthma; cell; increase; lung; patient; result; study summary = Results Data indicate splice variant expression in dendritic cells from asthmatic patients is influenced by asthma severity. Methods Randomized controlled trials (RCTs) of GORD treatment in adults or children that reported asthma health outcomes and had symptomatic GORD were included and assessed in accordance with the standard Cochrane systematic review process. Results 11 male (44%) and 14 female (56%) patients with moderate to severe persistent asthma (mean age 44 years, SD = 11) participated. Methods A comprehensive range of intracellular T-cell and monocyte proand anti-inflammatory cytokines/chemokines was investigated in peripheral blood from 5 OSA patients and 5 aged-matched control subjects (with no evidence of sleep problems) using multiparameter flow cytometry. Methods Following completion of a 12-month exercise study, which included a supervised program (Intervention, n = 18) and control group (Control, n = 17), COPD subjects [mean age (SD): 66 (8); mean FEV1 (% predicted) = 56% (19)] were asked to complete a questionnaire. doi = 10.1111/j.1440-1843.2008.01252_3.x id = cord-023333-b7w9zrl6 author = nan title = Oeld/Population Health SIG: Poster Session date = 2011-03-21 keywords = ASM; COPD; FEV; HRV; Interest; Nil; airway; cell; increase; method; patient; result; study summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. doi = 10.1111/j.1440-1843.2011.01937_10.x id = cord-023343-y17z9w2x author = nan title = COPD SIG: Poster Session 1 date = 2011-03-21 keywords = ASM; COPD; FEV; HRV; Interest; Nil; airway; cell; increase; method; patient; result; study summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. doi = 10.1111/j.1440-1843.2011.01937_5.x id = cord-023346-8sqbqjm1 author = nan title = MONDAY: POSTERS date = 2005-06-08 keywords = ABO; DAT; FFP; HBV; HCV; HIV; HLA; Hospital; NAT; PCR; RBC; RHD; RNA; TRALI; Transfusion; anti; antibody; blood; cell; dna; donor; group; method; patient; platelet; result; study; system; test summary = • enhancement of automation/computerisation; • process control to provide an ''error-free pathway''; • (national) surveillance and trend analysis of results, preferably based on national working standards; • significantly increased sensitivity, especially from development of antigen/antibody ''combi'' assays (e.g. for HIV, and recently, for HCV); • awareness of HBsAg vaccine-escape mutants and design of assays to cope with this; • extension of range of agents and markers tested for (varies in different countries); • increasing range of assays available for testing donors with a relevant history of exposure to malaria or Chagas'' disease infection (for retrieval of otherwise wasted blood); • European Union''s in vitro diagnostics directive: this has caused some problems and reduced flexibility. doi = 10.1111/j.1423-0410.2005.00652.x id = cord-023353-2yoz1t6a author = nan title = ABSTRACTS FROM THE 2010 EVDI ANNUAL MEETING date = 2010-12-28 keywords = Doppler; MRI; Purpose; University; Veterinary; cat; conclusion; dog; image; lesion; method; result; study summary = 3 Department of Physiology and Biometry, Ghent University, Belgium Introduction/Purpose: The microbubble-based contrast agents for ultrasonography have become more used in recent years in dogs1, and have been reported to be useful in differentiating adenomas from nonadenomatous lesions in human patients with adrenal masses2. Peak intensity Time to Introduction/Purpose: Studies with contrast enhanced ultrasonography (CEUS) on focal splenic lesions have shown discrepancies in accuracy for differentiating benign from malignant lesions.1-3 A speculative explanation for false positives may be the absence of a dual blood supply to the spleen compared to the liver. 1 The aim of the study was to test the hypothesis that the suggested maximum normal kidney size obtained from radiographs is too high and also to evaluate whether breed type (brachycephalic, doliocephalic, mesocephalic), age, gender, weight and body condition of the dog have an impact on kidney size. doi = 10.1111/j.1740-8261.2010.01774.x id = cord-023354-f2ciho6o author = nan title = TUESDAY PLENARY SESSION 3 TUESDAY: POSTERS date = 2005-06-08 keywords = ABO; DAT; FFP; HBV; HCV; HIV; HLA; Hospital; NAT; PCR; RBC; RHD; RNA; TRALI; Transfusion; anti; antibody; blood; cell; dna; donor; group; method; patient; platelet; result; study; system; test summary = • enhancement of automation/computerisation; • process control to provide an ''error-free pathway''; • (national) surveillance and trend analysis of results, preferably based on national working standards; • significantly increased sensitivity, especially from development of antigen/antibody ''combi'' assays (e.g. for HIV, and recently, for HCV); • awareness of HBsAg vaccine-escape mutants and design of assays to cope with this; • extension of range of agents and markers tested for (varies in different countries); • increasing range of assays available for testing donors with a relevant history of exposure to malaria or Chagas'' disease infection (for retrieval of otherwise wasted blood); • European Union''s in vitro diagnostics directive: this has caused some problems and reduced flexibility. doi = 10.1111/j.1423-0410.2005.00654.x id = cord-023364-ut56gczm author = nan title = EDUCATION DAY MONDAY: PLENARY SESSION 1 MONDAY: PARALLEL SESSIONS date = 2005-06-08 keywords = ABO; DAT; FFP; HBV; HCV; HIV; HLA; Hospital; NAT; PCR; RBC; RHD; RNA; TRALI; Transfusion; anti; antibody; blood; cell; dna; donor; group; method; patient; platelet; result; study; system; test summary = • enhancement of automation/computerisation; • process control to provide an ''error-free pathway''; • (national) surveillance and trend analysis of results, preferably based on national working standards; • significantly increased sensitivity, especially from development of antigen/antibody ''combi'' assays (e.g. for HIV, and recently, for HCV); • awareness of HBsAg vaccine-escape mutants and design of assays to cope with this; • extension of range of agents and markers tested for (varies in different countries); • increasing range of assays available for testing donors with a relevant history of exposure to malaria or Chagas'' disease infection (for retrieval of otherwise wasted blood); • European Union''s in vitro diagnostics directive: this has caused some problems and reduced flexibility. doi = 10.1111/j.1423-0410.2005.00651.x id = cord-023442-4vzwc2d2 author = nan title = Proceedings of SCANNING 94/SEEMS 94 Charleston, South Carolina, USA date = 2006-12-05 keywords = Carlo; EPMA; Fig; Monte; Mott; SEM; Scanning; Supplement; TEM; USA; Vol; beam; cell; electron; figure; high; image; microscopy; result; sample; section; specimen; structure; study; surface summary = IV-4 Scanning Vol. 16, Supplement IV (1994) Simulation of image formation and detection systems in the SEM is a vital link in performing image analysis to obtain precise measurements, to provide the necessary connection between image parameters and structural dimensions, and to reflect important microscope beam and detector parameters. By knowing the transfer function, noise, and distortion figure in digital form, it is relatively easy to obtain more accurate comparison of the measured and calculated signal (Fig. 1 The calculation of image contrast in the scanning electron microscope (SEM) can be done using Monte Carlo techniques if the electron trajectories can be calculated through the composition profiles in the specimen. Specimens providing IV-18 Scanning Vol. 16, Supplement IV (1994) FIG highly redundant structures and relatively smooth fractures, such as cell suspensions or o/w emulsions, were investigated using freeze fracture/replication and ambient temperature transmission electron microscopy (AT-TEM). doi = 10.1002/sca.4950160315 id = cord-029211-6o7qn2y2 author = nan title = Press review date = 2020-07-15 keywords = ICG; patient; study summary = In this study, we aimed to report the 5-year oncological outcomes, including local recurrence, metastatic disease, and survival. Patients age 18 years and older with T2T3 low rectal cancer, of maximum size 4 cm, who were clinically good responders after chemoradiotherapy (residual tumour ≤ 2 cm) were randomly assigned before surgery to either local excision or total mesorectal excision. The primary objective of this study was to assess the 5-year oncological outcomes of local recurrence, metastatic disease, disease-free survival, overall survival, and cancer-specific mortality, which were the secondary endpoints of GRECCAR 2. After 2 years, overall and disease-free survival tended to be improved in simultaneous as compared with delayed-resection groups (P 0.05), a tendency which persisted for OS after a median follow-up of 47 months. This retrospective monocenter study analyzed the shortand long-term outcomes of pancreatectomies associated with arterial resection for patients with either borderline (27%) or locally advanced (73%) pancreatic adenocarcinoma. doi = 10.1016/j.jviscsurg.2020.06.014 id = cord-030725-876arxiu author = nan title = September 2020 New in Review date = 2020-08-20 keywords = analysis; hispanic; sample; study summary = Researchers assessed nutritional risks among older patients diagnosed with COVID-19 along with their associated clinical outcomes. The NRS 2002 was designed to predict clinical effects of nutritional treatment in hospital settings with two levels: level 1 and level 2 contained factors of BMI status, weight loss history, nutritional intake, and disease severity. Association of work requirements with Supplemental Nutrition Assistance Program participation by race/ ethnicity and disability status, 2013-2017. Dietary patterns studied included the Alternative Healthy Eating Index, Dietary Approaches to Stop Hypertension diet score, and Mediterranean-style, adherence to which was determined via the food frequency questionnaire. Association between lifestyle factors, vitamin and garlic supplementation, and gastric cancer outcomes: A secondary analysis of a randomized clinical trial. A secondary analysis of a randomized controlled trial was performed to examine this issue using a sample of 3,365 participants. Demographic variables taken included age, sex, race/ethnicity, participation in the Supplemental Nutrition Assistance Program, family income level, education of parents, and health insurance status. doi = 10.1016/j.jand.2020.07.010 id = cord-031907-ilhr3iu5 author = nan title = ISEV2020 Abstract Book date = 2020-07-15 keywords = CD63; CD81; CD9; CDC; CRC; CSF; ELISA; Exo; Extracellular; GBM; HER2; HIV; Health; Institute; L1CAM; MDA; MSC; NIH; NTA; Nanoparticle; National; PCR; RNA; Research; SEC; TEM; Tau; USA; University; analysis; cancer; cell; conclusion; dna; exosome; expression; high; human; introduction; isolate; marker; method; patient; plasma; protein; result; sample; size; study; summary; vesicle; western summary = L.M., and the National Institutes of Health (R35GM119623) to T.R.G. The addition of a size exclusion chromatography step to various urinary extracellular vesicle concentrating methods reveals differences in the small RNA profile Introduction: Urinary extracellular vesicles (EVs) and their RNA cargo are a novel source of biomarkers for various diseases, however non-vesicular RNA (e.g. associated with proteins) is also present within urine. We then evaluated efficiency of heart targeting for eAAV9 or eAAV6 and standard AAV9 or AAV6 encoding for EGFP, mCherry or firefly luciferase in different human cell lines in vitro, in black mouse and in passive immunity nude mouse model in vivo using flow cytometry, confocal microscopy, Langendorff perfusion system and Methods: HLHS patients (n = 3) after Glenn procedure and swine (n = 3) after PAB were given RV injections of allogeneic/xenogeneic MSCs. Donor-specific, HLA-I+, exosomes were isolated from plasma. doi = 10.1080/20013078.2020.1784511 id = cord-032379-pelz3ygf author = nan title = October 2020 New in Review date = 2020-09-21 keywords = analysis; dietary; sample; study summary = Using a social constructivist perspective for analysis, the researchers designed a retrospective biographical study, using a sample of 30 adults. Researchers examined the shape of sexspecific associations of dietary protein intake with 3-and 6-year changes in muscle mass and gait speed, as well as mobility limitation in older adults. A randomized controlled trial using a sample of 140 participants was designed to test this question. Researchers investigated the relationship between sedentary behavior, walking, and high-intensity physical activity (HIPA), and risk factors for cardiovascular disease among adults and older adults. Long-term development effect of withholding parenteral nutrition in pediatric intensive care units: A 4-year follow-up of the PEPaNIC randomized controlled trial. The efficacy of prebiotic, probiotic, and symbiotic supplementation in modulating gut-derived circulatory particles associated with cardiovascular disease in individuals receiving dialysis: A systematic review and meta-analysis of randomized controlled trials Dietary intake and biomarkers of linoleic acid and mortality: Systematic review and meta-analysis of prospective cohort studies doi = 10.1016/j.jand.2020.08.011 id = cord-257167-rz4r5sj7 author = nan title = Abstracts for the 29th Annual Meeting of the Japan Neuroscience Society (Neuroscience2006) date = 2006-12-31 keywords = Anatomy; BDNF; BSI; Biology; Brain; CA1; CNS; CREST; Center; Chiba; Department; Dept; Div; Division; Engineering; Fos; GABA; GFP; Graduate; Hiroshi; Institute; JST; Japan; KAKENHI; Kobe; Kyoto; LTD; LTP; Laboratory; Life; Medical; Medicine; NMDA; Nagoya; National; Neuroscience; Niigata; Okazaki; Osaka; PS1A; PS2P; PS3A; Physiology; Purkinje; RIKEN; Research; Saitama; Sato; School; Science; Sendai; Takashi; Technology; Tohoku; Tokyo; Tsukuba; USA; University; Wako; activity; cell; effect; mouse; neuron; neuronal; ps3p; response; result; study summary = SY1-3-11-3 SAD: A novel kinase implicated in phosphoproteome at the presynaptic active zone Toshihisa Ohtsuka Department of Clinical and Molecular Pathology, Faculty of Medicine/Graduate School of Medicine, University of Toyama, Toyama, Japan SAD is a serine/threonine kianse, which has been shown to regulate various neuronal functions during development, including clustering synaptic vesicles, maturation of synapses, and axon/dendrite polarization: these have recently been revealed by genetic studies in C. The results suggest that EAAT4 plays a major role in regulating the concentration of CF transmitters, possibly glutamate, in the route of its extrasynaptic diffusion, and determining the degree of CF-induced inhibition of GABA release from BCs depending on the regional difference of EAAT4 expression in postsynaptic PCs. Chitoshi Takayama 1 , Yoshiro Inoue 1 1 Department of Molecular Neuroanatomy, Hokkaido University School of Medicine, Sapporo, Japan GABA mediates inhibitory transmission in the adult central nervous system (CNS). doi = 10.1016/j.neures.2006.04.004 id = cord-282783-ps5jyjkl author = nan title = Full Issue PDF date = 2020-09-30 keywords = CCS; ICI; Table; cancer; cardiovascular; disease; heart; patient; risk; study summary = The Childhood Cancer Survivor Study showed a 10-fold higher risk of pericardial disease in all CCS versus siblings (30year cumulative incidence, 3 .0%) and a dose-response relation with chest RT (11) . The literature on ECG abnormalities in large cohorts of long-term CCS is sparse (46, 47) , Data on the use of ambulatory ECG monitoring to define the prevalence of brady-and tachyarrhythmias induced by cardiotoxic cancer treatments are needed, but must be carefully weighed against the potential patient burden and clinical significance. Interestingly, a prior study in testicular cancer survivors showed that those patients who were exposed to cisplatin-based chemotherapy nearly 3 to more than 20 years ago had a more severe reduction in FMD and higher levels of circulating endothelial cells than those not exposed (13) . doi = 10.1016/s2666-0873(20)30180-0 id = cord-291540-raksomda author = nan title = July 2020 New in Review date = 2020-07-31 keywords = analysis; sample; study summary = Studies were eligible for inclusion if they investigated the effect of a choice architecture intervention on physical activity or sedentary behavior as well as the intention to engage in these; studied an adult population older than 18 years; and contained an experimental or quasi-experimental study design. Int J Behav Nutr Phys Act. 2020 ; https://doi.org/ 10.1186/s12966-020-00948-1. Inclusion criteria included samples representing direct supply-side stakeholders with a role in menu labeling implementation; interventions with no menu labeling format; all primary research studies using qualitative, quantitative, or mixed methods approaches; no restrictions on language or publication year; and outcomes measuring any barrier or facilitator to the implementation of menu labeling. Effects of resistant starch interventions on circulating inflammatory biomarkers: A systematic review and meta-analysis of randomized controlled trials. The sample of participants across the studies had a mean age of 49.0 years, a median of mean body mass index (BMI) of 33.0, a median of mean weight of 92.9 kg, a median proportion of women at 69%, and a median intervention duration of 26 weeks. doi = 10.1016/j.jand.2020.05.005 id = cord-326785-le2t1l8g author = nan title = Pathological Society of Great Britain and Ireland. 163rd meeting, 3–5 July 1991 date = 2005-06-15 keywords = HPV; biopsy; bone; carcinoma; case; cell; change; disease; dna; expression; increase; lesion; normal; number; patient; present; renal; section; small; specimen; stain; study; tissue; type summary = The lesions (usually multlpleand each 5 mm orless m diameter) were identified in lung parenchymaat a distance from the tumour and consisted of thickened alveolar walls lined by prominent, distinctly atypical cells morphologically Slmllar to type I 1 pneumacytes and cytologically different to the associated turnour Reactive changes 8" lung involved by obstrmtive pneumonitis were not included !n thts Sews All of the associated tumwra were peripheral adenocarcinamas and all showed a pattern of alveolar wall spread at the tumour periphery Clinically 7 of the patients were female and all were smokers or ex-smokers The slgnlflcance of this lesion in the histogenesis of primary pulmonary ademcarcinoma IS. doi = 10.1002/path.1711640412 id = cord-335975-m6lkrehi author = nan title = Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date = 2018-02-05 keywords = AKI; ARDS; CKD; December; ECMO; Fig; ICU; IQR; January; NIV; SAPS; VAP; care; day; group; introduction; mortality; patient; result; sofa; study summary = A qSOFA score relying on 3 simple clinical criteria (respiratory rate, mental status and systolic blood pressure) has been proposed to better identify septic patients with associated higher mortality outside the intensive care unit (Seymour CW et al., JAMA 2016) . We propose to determine whether the arterial oxygen pressure (PaO2) at intensive care unit (ICU) admission affects mortality at day 28 (D28) in patients with septic shock subjected to mechanical out-of-hospital ventilation. Conclusion: In this study, we report a significant association between hyperoxemia at ICU admission and mortality at D28 in patients with septic shock subjected to pre-hospital invasive mechanical ventilation. The aim of this study was to describe outcome of pediatric patient with hematologic disease hospitalized in our intensive care unit for respiratory failure and to investigate the clinical variables associated with mortality. doi = 10.1186/s13613-017-0345-7 id = cord-341063-3rqnu5bu author = nan title = 38th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 20-23 March 2018 date = 2018-03-29 keywords = AKI; APACHE; ARDS; Care; Critical; Fig; Hospital; ICU; IQR; IVC; Intensive; LOS; TBI; University; VAP; conclusion; day; group; high; introduction; method; mortality; patient; peep; result; score; sofa; study; table summary = Procacitonin (PCT) emerges as a possible predictive tool in cardiothoracic intensive care unit (CTICU).We aim at testing the predictive power of PCT for early morbidity, prolonged ventilation, ICU and hospital stay, in patients developing early fever after cardiac surgery Methods: A retrospective descriptive study done in tertiary cardiac center, enrolling patients who stayed for more than 24 hours post-operatively in the CTICU Risk stratification included additive Euro score and PCT immunoluminometricaly prior to surgery and every 48 hours in response to onset of fever. Prognostic accuracy of quick sequential organ failure assessment (qSOFA) score for mortality: systematic review and meta-analysis Introduction: The purpose of this study was to summarize the evidence assessing the qSOFA [1] , calculated in admission of the patient in emergency department (ED) or intensive care unit (ICU), as a predictor of mortality. doi = 10.1186/s13054-018-1973-5 id = cord-350571-6tapkjb6 author = nan title = 45th ESCP-NSF international symposium on clinical pharmacy: clinical pharmacy tackling inequalities and access to health care. Oslo, Norway, 5–7 October 2016 date = 2017-01-10 keywords = BZD; DRP; France; HCV; HIV; Hospital; January; June; Pharmacy; University; abstract; background; clinical; conclusion; descriptive; drug; medication; medicine; objective; patient; pharmacist; prescription; research; result; study; treatment; type summary = Possible solutions might be to use shared communication tools like Internet based communication programs and to introduce the patient as a participant at the IMRs. Please specify your abstract type: Research abstract Background and objective: International good pharmacy practice guidelines describe how pharmacists should counsel the patients about their medicines, offer additional services where needed, and intervene at drug related problems. Please specify your abstract type: Descriptive abstract (for projects) Background and objective: In order to improve the medication reconciliation and to implement training programs for the medical team in an associated to general hospital nursing (ASNH) home we measured the discrepancies between pharmacy registered treatments (PRT) and medical prescriptions (MP), and we analysed potentially inappropriate prescriptions according to ''''American Geriatrics Society 2015 Beers Criteria'''' and ''''STOPP-START 2014 criteria. doi = 10.1007/s11096-016-0404-4 id = cord-355038-o2hr5mox author = nan title = Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date = 2020-02-11 keywords = AKI; ARDS; CHU; COPD; Care; Correspondence; December; ECMO; Fig; France; Hospital; ICU; IQR; January; NIV; PICU; VAP; day; french; group; high; invitation; method; mortality; patient; rationale; result; sofa; study summary = Conclusion: In patients with moderate-to-severe ARDS, a higher tidal volume under PSV within the 72 h following neuromuscular blockers cessation is independently associated with the 28-day mortality.Compliance with ethics regulations: Yes. Kaplan-Meier estimate of the cumulative probability of survival according to the mean tidal volume (Vt)-lower of higher than 8 ml/ kg-under pressure support ventilation (PSV) during the "transition period" transfusion is associated with adverse events, and equipoise remains on the optimal transfusion strategy in oncologic patients in surgical setting. Compliance with ethics regulations: Yes. Patients and methods: In a retrospective monocentric study (01/2013-01/2017) conducted in cardio-vascular surgical intensive care unit (ICU) in Henri Mondor teaching hospital, all consecutive adult patients who underwent peripheral VA-ECMO were included, with exclusion of those dying in the first 24 h. Compliance with ethics regulations: Yes. Rationale: Acute respiratory failure is the leading reason for intensive care unit (ICU) admission in immunocompromised patients and the need for invasive mechanical ventilation has become a major clinical end-point in randomized controlled trials (RCT). doi = 10.1186/s13613-020-0623-7 id = cord-300176-lurzcliy author = van Mol, Margo M. C. title = Developing and testing a nurse-led intervention to support bereavement in relatives in the intensive care (BRIC study): a protocol of a pre-post intervention study date = 2020-08-18 keywords = ICU; care; relative; study summary = The aim of this study is to develop and implement a multicomponent bereavement support intervention for relatives of deceased ICU patients and to evaluate the effectiveness of this intervention on complicated grief, anxiety, depression and posttraumatic stress in bereaved relatives. This international group of experts suggested in their study to further explore the needs of the relatives, to test the efficacy of interventions in bereavement care and to develop guidelines for ICUs aiming to adequately deliver support to relatives during this difficult situation. The aims of the BRIC (Bereavement in Relatives in the Intensive Care) study for bereaved relatives of deceased ICU patients are: 1) to develop and implement a multicomponent nurse-led intervention, 2) to explore the experiences with bereavement care such as aspects of communication, quality of ding and death, and quality of support to relatives, 3) to determine the effectiveness of this intervention on complicated grief, anxiety, depression and posttraumatic stress and 4) to identify determinants and risk factors of complicated grief. doi = 10.1186/s12904-020-00636-8 id = cord-327460-wvd8hnfi author = van der Watt, A. S. J. title = Distant mood monitoring for depressive and bipolar disorders: a systematic review date = 2020-07-22 keywords = distant; monitoring; mood; study summary = METHODS: This systematic review synthesises quantitative and qualitative evidence of the effectiveness and feasibility of daily/weekly/monthly remote mood monitoring that includes distant support in participants with mood disorders. A systematic review of the validity of electronic self-monitoring of mood using information technology (IT) platforms in adults with bipolar disorder found evidence of their validity when compared to clinical rating scales for depression [9] . We synthesised quantitative and qualitative evidence on the effectiveness and feasibility of daily/weekly/monthly remote mood monitoring in participants with any mood disorder (as defined above) by clinicians, lay counsellors, and researchers (hereafter referred to as distant supporters), or where regular feedback was provided by distant supporters in cases where mood states were selfassessed. All quantitative studies were included as well as studies that qualitatively assessed participants'' perceived effectiveness, feasibility, and acceptability of distant mood monitoring offered by distant supporters. doi = 10.1186/s12888-020-02782-y id = cord-269015-850bvb9t author = Östlund, Ulrika title = Combining qualitative and quantitative research within mixed method research designs: A methodological review date = 2011-03-31 keywords = Erzberger; Kelle; method; mixed; study summary = This paper explores the analytical approaches (i.e. parallel, concurrent or sequential) used in mixed methods studies within healthcare and exemplifies the use of triangulation as a methodological metaphor for drawing inferences from qualitative and quantitative findings originating from such analyses. This paper explores the analytical approaches (i.e. parallel, concurrent or sequential) used in mixed methods studies within healthcare and exemplifies the use of triangulation as a methodological metaphor for drawing inferences from qualitative and quantitative findings originating from such analyses. Papers reporting on mixed methods studies within healthcare research were reviewed to (i) determine the type of analysis approach used, i.e. parallel, concurrent, or sequential data analysis and, (ii) identify studies which could be used to illustrate the use of the methodological metaphor of triangulation suggested by Erzberger and Kelle (2003) . doi = 10.1016/j.ijnurstu.2010.10.005 id = cord-318209-llucxztc author = Öztürk, Selçuk title = Therapeutic Applications of Stem Cells and Extracellular Vesicles in Emergency Care: Futuristic Perspectives date = 2020-08-24 keywords = ARDS; MSC; cell; clinical; stem; study; therapeutic summary = A phase-1 clinical trial investigating autologous BM-derived mononuclear cell (BM-MNC) infusion in pediatric TBI patients indicated that Fig. 1 Main pathological conditions requiring acute emergency care that can benefit from stem cell therapies or extracellular vesicle therapies in the future harvesting and infusion of stem cells is safe in children with no infusion related toxicity or death [30] . The regenerative potential of various types of stem cells, with different sources, dosages, delivery routes, application times and end-points has been investigated in preclinical animal models and human clinical trials with the expectation that these cells would successfully engraft into the damaged brain tissue, differentiate into functional neuronal and vascular system cells and promote full recovery after stroke. A recently published systematic review of 76 studies testing stem cells in rodent ischemic stroke models and 4 randomized human clinical trials encompassing ischemic stroke patients treated with autologous stem cells with at least one year follow-up period demonstrated that stem cell therapies show beneficial effects in terms of behavior and histological outcomes in rodents. doi = 10.1007/s12015-020-10029-2 id = cord-006636-xgikbdns author = Ühlein, E. title = Übersicht Über neue ernährungswissenschaftliche Publikationen date = 1964-02-01 keywords = Ern; Nutrition; Studies; Zur; acid; der; die; effect; feed; food; growth; influence; metabolism; milk; protein; study; und; vitamin; yon summary = L. : Effect of a low dietary level of three types of fat on reproductive performance and tissue lipid content of the vitamin B6-deficicnt female rat. H.: Effect of dietary protein and fat on growth, protein utilization, and carcass composition of pigs fed purified diets. Effect of food fats on concentration of ketone bodies and citric acid level in blood and tissues Effect of a low dietary level of three types of fat on reproductive performance and tissue lipid content of the vitamin B6-defieient female rat The effect on the serum cholesterol levels of the consumption of a special dietary fat with a high content of unsaturated fatty acids in elderly people Effect of protein intake and cold exposure on selected liver enzymes associated with amino acid metabolism Effect of protein intake and cold exposure on selected liver enzymes associated with amino acid metabolism doi = 10.1007/bf02021334