id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-354592-vqws942c	Cauvin, Annick J.	Advantages and Limitations of Commonly Used Nonhuman Primate Species in Research and Development of Biopharmaceuticals	2015-03-20		.txt	text/plain	7293	317	34	The marmoset also has been used as a nonrodent second species in drug safety assessment of new chemical entities (NCEs) and, more recently, of biopharmaceuticals based on side effects, findings of given drugs, and metabolizing enzymes or receptors found to be similar to humans [16] [17] [18] [19] ; because of the closer phylogenetic relationship to humans than other second species such as the dog, common marmosets may be more suitable for certain types of PART 7 NHP-SPECIFIC ASPECTS OF STANDARD TOXICOLOGY STUDIES pharmacokinetic and toxicological screening. Conversely, study designs for use with NHPs do not cover all aspects of reproduction (e.g., direct fertility assessment through mating or egg implantation-pregnancy cannot be confirmed until day 20 of gestation) and so may not allow a full evaluation of the specific risks in humans. The cynomolgus monkey has been used as a relevant toxicology species for immunostimulatory agents such as Toll-like receptor agonists; however, while special recognition regarding the clinical risk of systemic cytokine release for certain targets is warranted, the NHP is not always predictive of this potential toxicity in humans.	./cache/cord-354592-vqws942c.txt	./txt/cord-354592-vqws942c.txt