id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-336131-7xqi1mnx	Gupta, Manika	Preclinical Studies of MSC-Derived Extracellular Vesicles to Treat or Prevent Graft Versus Host Disease: a Systematic Review of the Literature	2020-11-07		.txt	text/plain	4703	228	43	The use of mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) appears promising and a systematic review of preclinical studies is needed to accelerate the design of translational studies. In brief, eligible studies included the treatment or prevention of GVHD in animal models and the use of MSC-EVs. Study design and outcome data were extracted and reporting was evaluated using the SYRCLE tool to identify potential bias. There is a need to perform a systematic review to identify the extent to which MSC-EVs are effective in treating or preventing GVHD and to inform potential future preclinical and clinical studies regarding the optimal method of isolating and administering EVs, including aspects such as dosing and route of administration and schedules of EV treatment. Extracellular vesicles released from human umbilical cord-derived mesenchymal stromal cells prevent lifethreatening acute graft-versus-host disease in a mouse model of allogeneic hematopoietic stem cell transplantation	./cache/cord-336131-7xqi1mnx.txt	./txt/cord-336131-7xqi1mnx.txt