id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-327607-g0jtrwot	Weinberg, Marc Scott	Clinical Trials and Tribulations in the COVID-19 Era	2020-05-19		.txt	text/plain	4312	169	39	Here we describe novel approaches and work-flow adaptations to study visits, drug delivery and interim and endpoint safety and outcomes assessments to avoid sacrificing years of preparation and substantial financial investments, to work in the best interest of participants and their caregivers, and to continue on the path towards discovering disease-modifying treatments for the millions of individuals impacted by major neurocognitive disorders. Here we describe novel approaches and work-flow adaptations to study visits, drug delivery and interim and endpoint safety and outcomes assessments to avoid sacrificing years of preparation and substantial financial investments, to work in the best interest of participants and their caregivers, and to continue on the path towards discovering disease-modifying treatments for the millions of individuals impacted by major neurocognitive disorders. While some of the same challenges limiting safety / biomarker visits also apply to in-person clinical and cognitive scale administration, there is already a literature base providing at least provisional support for the validity and reliability of performing assessments via tele-neuropsychology (TeleNP), including in older adults (e.g., [8] [9] [10] [11] [12] .	./cache/cord-327607-g0jtrwot.txt	./txt/cord-327607-g0jtrwot.txt