id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-028963-u4iupl1s	Lane, Michael	Multiple Sclerosis	2020-07-10		.txt	text/plain	11851	567	46	Natalizumab is a monoclonal antibody against α-4 integrin that prevents inflammatory cells from entering the CNS and has been shown to decrease the annualized relapse rate by 68% and reduce disease activity (new or enlarging MRI lesions) by 83% over 2 years compared with placebo. Based on current knowledge of the pathogenesis of MS, the rationale of using the Swank diet or other diets low in saturated fats in patients with MS relates to the general health benefits of such a diet and the anti-inflammatory and perhaps neuron membrane-stabilizing effects of a diet enriched with O3FAs. Although the consumption of red meat is significantly restricted on the Swank diet, fish appears to be particularly indicated because of its excellent protein content and, perhaps more importantly, its high content of O3FAs. Cold-water fish such as mackerel, salmon, and herring are rich in O3FAs, which include eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). One open-label study in RRMS patients (n = 10) showed a significant decrease in MMP-9 levels secreted from unstimulated immune cells after supplementing with fish-oil concentrate at 8 g/day (containing 2.9 g EPA and 1.9 g DHA) for 3 months.	./cache/cord-028963-u4iupl1s.txt	./txt/cord-028963-u4iupl1s.txt