id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-022594-fx044gcd	Pirko, Istvan	Demyelinating Disorders of the Central Nervous System	2009-05-18		.txt	text/plain	25103	1371	46	If a patient presents with a history of two or more attacks, but objective clinical evidence only suggests one lesion, the following additional data is needed to confirm the diagnosis: the disease process has to be disseminated in space as demonstrated by MRI; alternatively, two or more MRI-detected lesions consistent with MS plus positive CSF would suffice to meet the newly defined criteria. The EBM calculations regarding this trial show an RRR of 24%, and ARR of 11%, and an NNT of 9 patients over 2 years in order to prevent one conversion to "clinically definite MS." These two studies provide support for considering early treatment in patients presenting with first attack, in the presence of multiple asymptomatic MRI lesions, but further studies are needed to determine whether this approach will provide a prolonged benefit on disease course.	./cache/cord-022594-fx044gcd.txt	./txt/cord-022594-fx044gcd.txt